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Testosterone AND Supplement

Dalia A Mohamed, Shaimaa A Abdelrahman
Exposure to nicotine in smoking contributes to most unexplained male infertility but the mechanisms remain to be fully elucidated. Zinc (Zn) is an essential trace element in normal growth, development and reproduction. Zinc oxide nanoparticles (ZnONPs) are well-known antioxidants. Therefore, this work was designed to investigate the potential ability of ZnONPs to protect testis and epididymis in nicotine-treated rats. Forty adult male Wistar albino rats were divided into control group and two experimental groups (treated and supplemented rats)...
September 14, 2018: Cell and Tissue Research
Mehri Jamilian, Shirin Mansury, Fereshteh Bahmani, Zahra Heidar, Elaheh Amirani, Zatollah Asemi
BACKGROUND: The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS...
September 14, 2018: Journal of Ovarian Research
Kidmealem Zekarias, Rupendra T Shrestha
OBJECTIVE: Exercise Hypogonadal Male Condition (EHMC) is a well-recognized condition in women but much less understood in men. The aim of this case report is to highlight exercise induced hypogonadotropic hypogonadism in a male who recovered with lifestyle modifications. METHODS: We report a case of an adolescent male who developed hypogonadotropic hypogonadism secondary to excessive exercise and malnutrition that was followed up for a year without exogenous testosterone supplementation...
September 12, 2018: Medicine and Science in Sports and Exercise
Kerry L Hildreth, Robert S Schwartz, Joseph Vande Griend, Wendy M Kohrt, Patrick J Blatchford, Kerrie L Moreau
The cardiovascular effects of testosterone (T) are controversial. Low T has been associated with accelerated vascular aging, characterized by large elastic artery stiffening (decreased compliance), intimal-medial thickening (IMT), and endothelial dysfunction. Endurance exercise improves vascular function, but resistance training may increase arterial stiffness. We sought to determine whether T supplementation improved markers of vascular aging in men with low-normal T, and whether T supplementation prevented arterial stiffness with resistance exercise...
September 6, 2018: Journal of Applied Physiology
Violetta Mohos, Tímea Bencsik, Gabriella Boda, Eszter Fliszár-Nyúl, Beáta Lemli, Sándor Kunsági-Máté, Miklós Poór
Polyphenols are abundant molecules in the plant kingdom. They interact with several proteins in the body resulting in their complex biological effects. Previous studies demonstrated that polyphenols can interfere significantly with the pharmacokinetics of drugs by acting on their biotransformation, albumin-binding, and/or carrier-mediated transport. Casticin (CAS), ipriflavone (IPR), and resveratrol (RES) are well-known polyphenols often added to dietary supplements in high doses. In this study, we investigated the albumin-binding of these polyphenols by fluorescence spectroscopy, and their ability to displace the Sudlow's Site I ligand warfarin and the Site II ligand naproxen by ultrafiltration...
August 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yiliyasi Mayila, Toshiya Matsuzaki, Takeshi Iwasa, Altankhuu Tungalagsuvd, Munksaihan Munkhzaya, Kiyohito Yano, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Minoru Irahara
PURPOSE: It is known that various types of stress in early life increase the incidence of diabetes, myocardial infarctions, and psychiatric disorders in adulthood. We examined the mechanism by which neonatal immune stress reduces sexual behavior in adult male rats METHODS: Male rats were randomly divided into 3 groups: the control (n = 17), post-natal day 10 lipopolysaccharide (PND10LPS) (n = 31), and PND25LPS (n = 16) groups, which received intraperitoneal injections of LPS (100 μg/kg) or saline (injection volume: ≤0...
August 18, 2018: International Journal of Developmental Neuroscience
Emese Domonkos, Július Hodosy, Daniela Ostatníková, Peter Celec
Testosterone affects brain functions and might explain some of the observed behavioral sex differences. Animal models may help in elucidating the possible involvement of sex hormones in these sex differences. The effects of testosterone have been intensively investigated, especially in anxiety models. Numerous experiments have brought inconsistent results with either anxiolytic or anxiogenic effects. Besides methodological variations, contradictory findings might be explained by the divergent metabolism of testosterone and its recognition by neurons during prenatal and postnatal development...
2018: Frontiers in Endocrinology
Albert P Li, Kirsten Amaral, Ming-Chih David Ho
We report here an evaluation of a novel experimental system- cofactor-supplemented permeabilized cryopreserved human enterocytes (MetMax™ cryopreserved human enterocytes (MMHE), patent pending) for applications in the evaluation of enteric drug metabolism. A major advantage of MMHE over conventional cryopreserved human enterocytes (CCHE) is the simplification of the use procedures including storage at -80o C instead of in liquid nitrogen, and use of the cells immediately after thawing without a need for centrifugation and microscopic evaluation of cell density and viability and cell density adjustment...
August 20, 2018: Drug Metabolism Letters
Hajer Dahmani, Kaouthar Louati, Adel Hajri, Senda Bahri, Fathi Safta
Several studies have highlighted that nutritional supplements may contain undeclared anabolic steroids that are banned by the International Olympic Committee/World Anti-Doping Agency. Any kind of abuse with these drugs is extremely dangerous because of their side effects. Thus, the control of food additives in order to protect the best consumer health and to limit fraudulent practices in the field of sports is essential. This paper describes a simple and effective qualitative gas chromatography-mass spectrometry (GC-MS) method to detect anabolic androgenic steroids (AAS): androsterone, nandrolene, dehydroepiandrosterone, 5ɑ-androstane-3β, 17β-diol, dihydrotestosterone, testosterone, methenolone acetate, methandienone, boldenone and fluoxymesterone, in food supplements...
October 2018: Steroids
Filipe J Teixeira, Catarina N Matias, Cristina P Monteiro, Maria J Valamatos, Joana Reis, Francisco Tavares, Ana Batista, Christophe Domingos, Francisco Alves, Luís B Sardinha, Stuart M Phillips
Leucine metabolites, α-hydroxyisocaproic acid (α-HICA) and β-hydroxy-β-methylbutyrate (calcium, HMB-Ca and free acid, HMB-FA), have been proposed to augment resistance training-induced changes in body composition and performance. PURPOSE: We aimed to conduct a double-blind randomized controlled pragmatic trial to evaluate the effects of off-the-shelf leucine metabolite supplements of α-HICA, HMB-FA and HMB-Ca, on resistance training-induced changes in muscle thickness, and performance...
August 10, 2018: Medicine and Science in Sports and Exercise
Samar Sakr, Hanan Hassanien, Megan Jean Bester, Sandra Arbi, Azza Sobhy, Heba El Negris, Vanessa Steenkamp
The aim of this study was to evaluate the protective effect of folate against methomyl-induced toxicity on the kidneys and testes of male rats. Adult male albino rats were divided into four groups; Group I served as the control (vehicle), Group II received folic acid (1.1 mg per kg b.wt.), Group III methomyl (1 mg per kg b.wt.) and Group IV folic acid and methomyl. Treatments were administered via oral gavage on a daily basis for 14 weeks. Thereafter blood samples were collected and serum creatinine, testosterone and total antioxidant capacity (TAC) were determined...
May 8, 2018: Toxicology Research
Hajar Oghbaei, Mohammad Reza Alipour, Gholamreza Hamidian, Mahdi Ahmadi, Vajihe Ghorbanzadeh, Rana Keyhanmanesh
NEW FINDINGS: What is the central question of this study? Can low-dose inorganic nitrate supplementation prevent testicular structural and functional alterations in streptozotocin-induced type 1 diabetic male rats? What is the main finding and it's important? Treatment with a low dose of inorganic nitrate for 2 months had protective effects on the male reproductive system in diabetic rats including improved body weight loss, sperm and testis parameters, spermatogenesis index and testicular histology as well as increased serum testosterone levels...
August 8, 2018: Experimental Physiology
Ting Zhou, Zhi-Yong Hu, Hui-Ping Zhang, Kai Zhao, Yu Zhang, Ying Li, Jia-Jing Wei, Hong-Fang Yuan
This study was designed to evaluate the effects of testosterone supplementation (TS) on body composition in patients with HIV and the side effects of TS. A comprehensive literature search strategy was used to retrieve relevant randomized controlled trials (RCTs) examining the effects of TS on body composition. Atotal of 14 eligible studies were included, enrolling 388 and 349 randomized patients in TS and control groups, respectively. The quality of studies included was assessed, and data on total body weight (BW), lean body mass (LBM), fat mass (FM), serum total testosterone (TT), free testosterone (FT) levels, and adverse events were extracted and analyzed using Review Manager software 5...
February 2018: Current medical science
Ping Chen, He Xiao, Wei Huang, De-Qiang Xu, Yu-Ming Guo, Xiao Wang, Xing-Huan Wang, Michael E DiSanto, Xin-Hua Zhang
BACKGROUND: Benign prostatic hyperplasia (BPH) is mainly caused by increased prostatic smooth muscle (SM) tone and prostatic volume. At the molecular level, SM myosin II (SMM II) and non-muscle myosin II (NMM II) mediate SM tone and cell proliferation while testosterone (T) plays a permissive role in the development of BPH. AIMS: The novel objective of this study was to elucidate the effects of T on the proliferation and apoptosis of rat prostatic cells and SM contractility as well as related regulatory signaling pathways...
August 2, 2018: Prostate
John A Batsis, Dennis T Villareal
The prevalence of obesity in combination with sarcopenia (the age-related loss of muscle mass and strength or physical function) is increasing in adults aged 65 years and older. A major subset of adults over the age of 65 is now classified as having sarcopenic obesity, a high-risk geriatric syndrome predominantly observed in an ageing population that is at risk of synergistic complications from both sarcopenia and obesity. This Review discusses pathways and mechanisms leading to muscle impairment in older adults with obesity...
September 2018: Nature Reviews. Endocrinology
Masoud Khorshidi, Ashraf Moini, Elham Alipoor, Neda Rezvan, Sattar Gorgani-Firuzjaee, Mehdi Yaseri, Mohammad Javad Hosseinzadeh-Attar
The aim of this study was to investigate the effect of quercetin on metabolic and hormonal parameters as well as plasma concentration and gene expression of resistin in overweight or obese women with polycystic ovary syndrome (PCOS). In this randomized, double-blind, placebo-controlled trial, 78 overweight or obese women (25 ≤ BMI ≤ 40 kg/m2 , 20-40 years) with PCOS were recruited. Patients were randomized to receive 1,000 mg/day quercetin or placebo for 12 weeks. Resistin plasma concentration and gene expression in peripheral blood mononuclear cells, parameters of glucose homeostasis, circulatory testosterone, luteinizing hormone (LH), and sex hormone-binding globulin, and anthropometries were assessed at baseline and at the end of the study...
July 30, 2018: Phytotherapy Research: PTR
Sandeep Kumar Chaudhary, Asit Baran Mandal, Rasbihari Bhar, M Gopi, A Kannan, Sunil E Jadhav, Jaydip J Rokade
Objective: This study investigated the effects of soapnut (Sapindus mukorossi) shell powder (SSP) on serum hormone level, egg quality, semen characteristics and reproductive performance of broiler breeders fed with the maize-soybean meal based diet. Methods: Ninety six female and twenty four male CARIBRO-VISHAL broiler breeders, 38-week old, were individually caged and randomly allocated to four treatment groups (24 female breeders/treatment and 6 male breeders/treatment): an un-supplemented control (T1) and three groups with 0...
July 26, 2018: Asian-Australasian Journal of Animal Sciences
Jeremy R Townsend, David Bender, William C Vantrease, Philip A Sapp, Ann M Toy, Clint A Woods, Kent D Johnson
We sought to determine the effects of probiotic supplementation ( Bacillus subtilis DE111; 1 billion CFU∙d-1 ) on markers of immune and hormonal status in collegiate male athletes following 12 weeks of offseason training. Twenty-five Division I male baseball athletes (20.1 ± 1.5 years, 85.5 ± 10.5 kg, 184.7 ± 6.3 cm) participated in this double blind, placebo-controlled, randomized study. Participants were randomly assigned to a probiotic (PRO; n = 13) or placebo (PL; n = 12) group. Pre- and post-training, all athletes provided resting blood and saliva samples...
July 26, 2018: Sports
Anton De Spiegeleer, David Beckwée, Ivan Bautmans, Mirko Petrovic
BACKGROUND: Sarcopenia, defined as the pathological decline in muscle mass, muscle strength and physical performance with aging, has become one of the geriatric giants because of its increasing prevalence and devastating health effects. The Belgian Society of Gerontology and Geriatrics (BSGG) is currently developing evidence-based guidelines for the prevention and therapy of sarcopenia for use in broad clinical practice. This systematic review summarizes the results of the Working Group on Pharmacology...
August 2018: Drugs & Aging
Stefan Poschner, Alexandra Maier-Salamon, Martin Zehl, Judith Wackerlig, Daniel Dobusch, Anastasia Meshcheryakova, Diana Mechtcheriakova, Theresia Thalhammer, Bettina Pachmann, Walter Jäger
The role of resveratrol (RES) in preventing breast cancer is controversial, as low concentrations may stimulate the proliferation of estrogen-receptor alpha positive (ERα+) breast cancer cells. As metabolism is the key factor in altering cellular estrogens, thereby influencing breast tumor growth, we investigated the effects of RES on the formation of estrogen metabolites, namely 4-androstene-3,17-dione (AD), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-3- O -sulfate (DHEA-S), estrone (E1), estrone-3-sulfate (E1-S), 17β-estradiol (E2), 17β-estradiol-3- O -(β-D-glucuronide) (E2-G), 17β-estradiol-3- O -sulfate (E2-S), 16α-hydroxy-17β-estradiol (estriol, E3), and testosterone (T) in ERα- MDA-MB-231 and ERα+ MCF-7 cells...
2018: Frontiers in Pharmacology
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