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Testosterone AND Supplement

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https://www.readbyqxmd.com/read/27914563/differential-effects-of-testosterone-and-estradiol-on-clitoral-function-an-experimental-study-in-rats
#1
Paolo Comeglio, Ilaria Cellai, Sandra Filippi, Chiara Corno, Francesca Corcetto, Annamaria Morelli, Elena Maneschi, Elisa Maseroli, Edoardo Mannucci, Massimiliano Fambrini, Mario Maggi, Linda Vignozzi
INTRODUCTION: Female sexual response is a complex phenomenon in which psychological, neurologic, and vascular mechanisms and hormonal factors interact. During the arousal phase, they cooperate to increase genital blood flow, thus inducing engorgement of the clitoris and lubrication of the vagina. Regulation of vascular and non-vascular smooth muscle tone is the crucial event in the erectile process. Preclinical studies have suggested that nitric oxide (NO) is the main vasodilator neurotransmitter modulating, through the second messenger cyclic guanosine monophosphate (cGMP), clitoral flow vessels...
December 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27901247/anabolic-steroids-for-rehabilitation-after-hip-fracture-in-older-people
#2
Vaqas Farooqi, Maayken E L van den Berg, Ian D Cameron, Maria Crotty
BACKGROUND: Hip fracture occurs predominantly in older people, many of whom are frail and undernourished. After hip fracture surgery and rehabilitation, most patients experience a decline in mobility and function. Anabolic steroids, the synthetic derivatives of the male hormone testosterone, have been used in combination with exercise to improve muscle mass and strength in athletes. They may have similar effects in older people who are recovering from hip fracture. OBJECTIVES: To examine the effects (primarily in terms of functional outcome and adverse events) of anabolic steroids after surgical treatment of hip fracture in older people...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27883172/can-an-intervention-with-testosterone-and-nutritional-supplement-improve-the-frailty-level-of-under-nourished-older-people
#3
O Theou, I Chapman, L Wijeyaratne, C Piantadosi, K Lange, V Naganathan, P Hunter, I D Cameron, K Rockwood, R Visvanathan
OBJECTIVE: To examine whether a testosterone and a high calorie nutritional supplement intervention can reduce frailty scores in undernourished older people using multiple frailty tools. DESIGN: Randomized controlled trial. SETTING/PARTICIPANTS: 53 community-dwelling, undernourished men and women aged >65 years from South Australia, Victoria and New South Wales. INTERVENTION: Intervention group received oral testosterone undecanoate and a high calorie supplement (2108-2416 kJ/day) whereas the control group received placebo testosterone and low calorie supplement (142-191 kJ/day)...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27872709/the-effect-of-sugar-cane-molasses-on-the-immune-and-male-reproductive-systems-using-in-vitro-and-in-vivo-methods
#4
Farzana Rahiman, Edmund John Pool
OBJECTIVES: Sugar cane molasses is a commonly used ingredient in several food products. Contrasting reports suggest that molasses may have potential adverse or beneficial effects on human health. However, little evidence exists that examines the effects of molasses on the different physiological systems. This study investigated the effects of sugar cane molasses on various physiological systems using in vivo and in vitro methods. MATERIALS AND METHODS: Molasses was administered orally to BALB/c, male mice and animals were randomly assigned into either a treatment or control group...
October 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27868316/effect-of-organic-and-inorganic-selenium-supplementation-on-semen-quality-and-blood-enzymes-in-buffalo-bulls
#5
Mohamed El-Sharawy, Entsar Eid, Samy Darwish, Ibrahim Abdel-Razek, Md Rashedul Islam, Kaiyu Kubota, Nobuhiko Yamauchi, Ibrahim El-Shamaa
The present study aimed to evaluate the effect of organic and inorganic selenium (Se) supplementation on semen quality and blood serum profiles of buffalo bulls. Nine mature buffalo bulls were divided into three groups: control (non-supplemented); organic Se (10 mg Sel-Plex®/head twice weekly) and inorganic Se (10 mg sodium selenite/head twice weekly). Semen was collected twice a week for 3 months during Se supplementation. Semen properties were evaluated from fresh ejaculate. Moreover, fructose concentration, aspartate and alanine transaminase (AST and ALT) activities, total protein and total cholesterol were assayed in seminal plasma...
November 21, 2016: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/27864020/regio-and-stereoselective-reduction-of-17-oxosteroids-to-17%C3%AE-hydroxysteroids-by-a-yeast-strain-zygowilliopsis-sp-wy7905
#6
Yuanyuan Liu, Yu Wang, Xi Chen, Qiaqing Wu, Min Wang, Dunming Zhu, Yanhe Ma
The reduction of 17-oxosteroids to 17β-hydroxysteroids is one of the important transformations for the preparation of many steroidal drugs and intermediates. The strain Zygowilliopsis sp. WY7905 was found to catalyze the reduction of C-17 carbonyl group of androst-4-ene-3,17-dione (AD) to give testosterone (TS) as the sole product by the constitutive 17β-hydroxysteroid dehydrogenase (17β-HSD). The optimal conditions for the reduction were pH 8.0 and 30°C with supplementing 10g/l glucose and 1% Tween 80 (w/v)...
November 15, 2016: Steroids
https://www.readbyqxmd.com/read/27824398/effects-of-quercetin-on-adiponectin-mediated-insulin-sensitivity-in-polycystic-ovary-syndrome-a-randomized-placebo-controlled-double-blind-clinical-trial
#7
N Rezvan, A Moini, L Janani, K Mohammad, A Saedisomeolia, M Nourbakhsh, S Gorgani-Firuzjaee, M Mazaherioun, M J Hosseinzadeh-Attar
Polycystic ovary syndrome (PCOS) is a heterogeneous, multi-causal, and genetically complex disorder, which is related to the failure in endocrine glands. Adiponectin has been reported to be low in PCOS, even in the absence of adiposity. Quercetin reduces serum glucose, insulin, triglycerides, and cholesterol levels and increases the expression and secretion of adiponectin. The aim of this study was to determine the effect of quercetin on the adiponectin-mediated insulin sensitivity in PCOS patients. Eighty-four women with PCOS were selected and randomly assigned to 2 groups of treatment and control...
November 7, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27811278/the-effects-of-transdermal-testosterone-and-oestrogen-therapy-on-dry-eye-in-postmenopausal-women-a-randomised-placebo-controlled-pilot-study
#8
Blanka Golebiowski, Noor Badarudin, John Eden, Leanne Gerrand, Jennifer Robinson, Jinzhu Liu, Ulrike Hampel, Jingjing You, Fiona Stapleton
AIMS: Sex hormones could provide a future treatment avenue for dry eye post menopause. However, there are few well-controlled studies. This study investigates the impact of testosterone and oestrogen on dry eye symptoms and signs in postmenopausal women. METHODS: A randomised double-blind placebo-controlled pilot study was conducted involving 40 women with dry eye (age 63.9±5.1 years, 13.2±6.3 years post menopause). Ten women were assigned to each of four treatment groups: transdermal testosterone, oestradiol, testosterone/oestradiol combination and placebo...
November 3, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27797674/effect-of-soy-in-men-with-type-2-diabetes-mellitus-and-subclinical-hypogonadism-a-randomized-controlled-study
#9
Thozhukat Sathyapalan, Alan S Rigby, Shalender Bhasin, Natalie J Thatcher, Eric S Kilpatrick, Stephen L Atkin
CONTEXT: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to hypogonadism. OBJECTIVE: The primary outcome was change in total testosterone levels. The secondary outcomes were the changes in glycaemia and cardiovascular risk markers. DESIGN: Randomised double blind parallel study...
October 31, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27773742/effects-of-isoliquiritigenin-on-ovarian-antral-follicle-growth-and-steroidogenesis
#10
Sharada Mahalingam, Liying Gao, Jacqueline Eisner, William Helferich, Jodi A Flaws
Isoliquiritigenin is a botanical estrogen used as a dietary supplement. Previous studies show that other botanical estrogens affect ovarian estradiol synthesis, but isoliquiritigenin's effects on the ovary are unknown. Thus, this study tested the hypothesis that isoliquiritigenin inhibits ovarian antral follicle growth and steroidogenesis. Antral follicles from CD-1 mice were cultured with vehicle control (dimethyl sulfoxide; DMSO) or isoliquiritigenin (0.6μM, 6 μM, 36 μM, and 100 μM) for 48-96h. During culture, follicle diameters were measured daily to assess follicle growth...
December 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27766021/dehydroepiandrosterone-supplementation-combined-with-whole-body-vibration-training-affects-testosterone-level-and-body-composition-in-mice
#11
Wen-Chyuan Chen, Yi-Ming Chen, Chi-Chang Huang, Yen-Dun Tzeng
Dehydroepiandrosterone (DHEA), the most abundant sex steroid, is primarily secreted by the adrenal gland and a precursor hormone used by athletes for performance enhancement. Whole-body vibration (WBV) is a well-known light-resistance exercise by automatic adaptations to rapid and repeated oscillations from a vibrating platform, which is also a simple and convenient exercise for older adults. However, the potential effects of DHEA supplementation combined with WBV training on to body composition, exercise performance, and hormone regulation are currently unclear...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27765882/testosterone-downregulates-angiotensin-ii-type-2-receptor-via-androgen-receptor-mediated-erk1-2-map-kinase-pathway-in-rat-aorta
#12
Jay S Mishra, Gary D Hankins, Sathish Kumar
INTRODUCTION: Blood pressure is lower in females than males. Angiotensin II type-2 receptor (AT2R) induces vasodilation. This study determined whether sex differences in vascular AT2R expression occur and if androgens exert control on AT2R expression in the vasculature. METHODS: AT2Rs in the aorta of male and female Sprague-Dawley rats were examined following alteration in androgen levels by gonadectomy or hormone supplementation. RESULTS: AT2R mRNA and protein expression levels were lower in the aortas of males than females...
October 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/27761321/positive-effect-of-dietary-lutein-and-cholesterol-on-the-undirected-song-activity-of-an-opportunistic-breeder
#13
Stefania Casagrande, Rianne Pinxten, Erika Zaid, Marcel Eens
Song is a sexually selected trait that is thought to be an honest signal of the health condition of an individual in many bird species. For species that breed opportunistically, the quantity of food may be a determinant of singing activity. However, it is not yet known whether the quality of food plays an important role in this respect. The aim of the present study was to experimentally investigate the role of two calorie-free nutrients (lutein and cholesterol) in determining the expression of a sexually selected behavior (song rate) and other behaviors (locomotor activity, self-maintenance activity, eating and resting) in male zebra finches (Taeniopygia guttata)...
2016: PeerJ
https://www.readbyqxmd.com/read/27754805/effects-of-testosterone-supplementation-for-3-years-on-muscle-performance-and-physical-function-in-older-men
#14
Thomas W Storer, Shehzad Basaria, Tinna Traustadottir, S Mitchell Harman, Karol Pencina, Zhuoying Li, Thomas G Travison, Renee Miciek, Panayiotis Tsitouras, Kathleen Hally, Grace Huang, Shalender Bhasin
CONTEXT: Testosterone's effects on muscle strength and physical function in older men have been inconsistent; its effects on muscle power and fatigability have not been studied. OBJECTIVE: To determine the effects of testosterone administration for 3 years in older men on muscle strength, power, fatigability and physical function Study Design: In this double-blind, placebo-controlled, randomized trial, healthy men ≥60 years with total testosterone 100-400 ng/dL or free testosterone <50 pg/mL, were randomized to 7...
October 18, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27752262/effect-of-myoinositol-and-antioxidants-on-sperm-quality-in-men-with-metabolic-syndrome
#15
Mario Montanino Oliva, Elisa Minutolo, Assunta Lippa, Paola Iaconianni, Alberto Vaiarelli
This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol®, which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27746005/dietary-supplementation-of-yucca-yucca-schidigera-affects-ovine-ovarian-functions
#16
Radoslava Vlčková, Drahomíra Sopková, Zuzana Andrejčáková, Igor Valocký, Attila Kádasi, Abdel Halim Harrath, Vladimír Petrilla, Alexander V Sirotkin
Yucca (Yucca schidigera) is a popular medicinal plant due to its many positive effects on animal and human physiology, including their reproductive systems. To examine the effect of supplemental yucca feeding on sheep reproduction, including ovarian functions and their hormonal regulators, ewes were fed (or not fed, control) yucca powder (1.5 g/head/day, 30 days). Macromorphometric indexes of the oviduct, ovary, and ovarian folliculogenesis were measured. Reproductive hormone levels in the blood were measured using a radioimmunoassay...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27742397/comparison-between-in-toto-peach-prunus-persica-l-batsch-supplementation-and-its-polyphenolic-extract-on-rat-liver-xenobiotic-metabolizing-enzymes
#17
Donatella Canistro, Fabio Vivarelli, Silvia Cirillo, Guglielmo Costa, Carlo Andreotti, Moreno Paolini
Over the past years, there has been a growing interest in the natural constituents of foods as a potential means of cancer control. To date, epidemiology studies seem to indicate an inverse association between regular consumption of fruit and vegetables and cancer risk. Here, the potential chemopreventive activity of the polyphenolic extract (PPE) of peach (Prunus persica L. Batsch) and of the freeze-dried fruit in toto (LFT), focusing on the modulation of xenobiotic metabolizing enzymes (XMEs) in vivo, was investigated...
October 11, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27734705/-testosterone-and-mortality
#18
Luboslav Stárka
Subnormal levels of testosterone are frequently found in men of higher age category. Hypogonadal men have lower life expectancy than men with full androgenization and cardiovascular disease, obesity or diabetes is often associated with hypotestosteronemia. Low testosterone level is risk factor for these diseases. However, until now it is not clear whether testosterone deficiency is a cause or consequence of atherosclerosis or metabolic syndrome. A handful of symptoms and metabolic risk markers in hypogonadal men can be ameliorated by testosterone supplementation...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27729112/caprine-ovarian-follicle-requirements-differ-between-preantral-and-early-antral-stages-after-ivc-in-medium-supplemented-with-gh-and-vegf-alone-or-in-combination
#19
J Cadenas, J Leiva-Revilla, L A Vieira, L B Apolloni, F L N Aguiar, B G Alves, C H Lobo, A P R Rodrigues, G A Apgar, J Smitz, J R Figueiredo, C Maside
The aim of the present study was to evaluate the effect of growth hormone (GH) and vascular endothelial growth factor (VEGF) added alone, sequentially or in combination, in the presence of insulin at physiological concentration (10 ng/mL) on the IVC of two different follicular categories: preantral (experiment 1; Exp.1) and early antral (experiment 2; Exp.2). Isolated follicles were individually cultured for 24 (Exp.1) and 18 days (Exp.2) in the following treatments: αMEM(+) (Control), or Control medium supplemented with 50 ng/mL GH (GH), 100 ng/mL VEGF (VEGF), the combination of both (GH + VEGF), GH during the first 12 days and VEGF from Day 12 until the end of the culture (GH/VEGF) and vice versa (VEGF/GH)...
September 13, 2016: Theriogenology
https://www.readbyqxmd.com/read/27673042/poster-286-an-ischemic-stroke-and-oral-testosterone-supplementation-in-a-young-male-a-case-study
#20
Brian J Mugleston, Jon A Benfield, Brian R Connolly, Blessen C Eapen
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
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