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Testosterone AND Supplement

Mahjoobe Tazari, Hasan Baghshani, Zahra Moosavi
The aim of this work was to study the alleviative role of betaine versus arsenite-provoked alterations in testis oxidative status and circulating androgenic indices. Twenty-four adult male rats (204.5 ± 21 g) were divided into four groups, equally. Control group was given basal diet and tap water. Group 2 rats received arsenite (100 mg/L) in drinking water. Rats in group 3 received betaine (2% of the diet) during arsenite exposure. Group 4 received betaine at 2% of the diet during study period (30 days)...
July 10, 2018: Andrologia
Reza Safari Asl, Farid Shariatmadari, Mohsen Sharafi, Mohammad Amir Karimi Torshizi, Abdolhossein Shahverdi
The purpose of this study was to evaluate the effects of dietary n-3: n-6 fatty acid (FA) ratios and vitamin E (vitE) on the semen quality, FA composition, hormonal responses, and reproductive performance of aged roosters. Thirty-six Ross broiler breeder roosters were assigned to a 3 × 2 factorial design with 3 n-3: n-6 FA ratios (0.09, 0.16, and 0.23) based on the inclusion of 3 oil sources (canola, canola/fish, and fish) and 2 vitE levels (0 and 200 mg/kg). During the 60 d of treatment, semen parameters, FAs composition of sperm, lipid peroxidation, and hormonal responses were monitored...
July 3, 2018: Poultry Science
Amr Hodhod, Yasser A Noureldin, Mohamed El-Sherbiny
Denys Drash Syndrome (DDS) is a rare combination of genital and urinary anomalies that are mostly associated with malignancy. We report 2 patients who presented with genital ambiguity and were diagnosed as 46-XY DDS. During the discussion of the management plan, parents preferred to keep the gonads to preserve its endocrinal function for future sexual development. However, both patients developed primary hypogonadism at puberty and required testosterone supplementation. Persevering gonads in such patients had no endocrinal benefits but put the patients at risk of malignant transformation...
July 5, 2018: Urologia Internationalis
Heather M Stieglitz, Nichole Korpi-Steiner, Brooke Katzman, Jennifer E Mersereau, Maya Styner
A perimenopausal woman presented with palpitations, hirsutism, and inability to lose weight. Laboratory tests revealed an unusual endocrine hormonal profile including pituitary hormones (TSH, ACTH, and prolactin) below reference intervals and gonadal (testosterone) and adrenal (cortisol) hormones above reference intervals. Ultimately, after a comprehensive workup including a scheduled surgical procedure, abnormal laboratories were determined due to biotin interference. Biotin (vitamin B7) is a water-soluble vitamin and essential cofactor for the metabolism of fatty acids, glucose, and amino acids...
June 1, 2018: Journal of the Endocrine Society
Joshua Coutinho, Justin B Field, Anupam A Sule
Armour® Thyroid (Forest Pharmaceuticals, LLC; affiliate of Allergan, Dublin, Ireland) is a natural porcine derivative thyroid supplement that is frequently used without physician monitoring by health enthusiasts as a weight loss supplement. Although there are no publications associating Armour Thyroid and major coronary events, significant drug interactions may exist. A 32-year-old male with a history of hypothyroidism, cystic acne, and solitary congenital kidney presented to the emergency room after experiencing crushing substernal chest pain radiating to his left shoulder, accompanied by diaphoresis and shortness of breath...
April 24, 2018: Curēus
Putri Ayu Jayusman, Isa Naina Mohamed, Ekram Alias, Norazlina Mohamed, Ahmad Nazrun Shuid
Male osteoporosis is associated with higher rates of disability and mortality. Hence the search for suitable intervention and treatment to prevent the degeneration of skeletal health in men is necessary. Eurycoma longifolia (EL), a traditional plant with aphrodisiac potential may be used to treat and prevent male osteoporosis. The skeletal protective effect of quassinoid-rich EL extract, which has a high content of eurycomanone, has not been studied. This study aimed to determine whether EL could prevent skeletal deteriorations in gonadal hormone-deficient male rats...
June 21, 2018: Nutrients
Huimin Zhao, Junyu Nie, Xiangxing Zhu, Yangqing Lu, Xingwei Liang, Huiyan Xu, Xiaogan Yang, Yunkai Zhang, Kehuan Lu, Shengsheng Lu
In this study, we attempted to establish a culture system for in vitro spermatogenesis from spermatogonial stem cells (SSCs) of Bama Mini-pig. The dissociated testicular cells from one-month pig were co-cultured to mimic in vivo spermatogenesis. The testicular cells were seeded in Minimum Essential Media alpha (α-MEM) supplemented with KnockoutTM Serum Replacement (KSR). Three-dimensional (3D) colonies were formed after 10 days culture. The colonies showed positive staining for SSC-associated markers such as UCHL1, PLZF, THY1, OCT4, Dolichos biflorus agglutinin (DBA) and alkaline phosphatase (AP)...
June 21, 2018: Journal of Veterinary Science
Lori L Ploutz-Snyder, Meghan Downs, Elizabeth Goetchius, Brent Crowell, Kirk L English, Robert Ploutz-Snyder, Jeffrey Ryder, E Lichar Dillon, Melinda Sheffield-Moore, Jessica M Scott
INTRODUCTION: This study investigated the safety and effectiveness of a new integrated aerobic and resistance exercise training prescription (SPRINT) using two different sets of exercise equipment: a suite of large ISS-like exercise equipment similar to what is found on the International Space Station (ISS) and a single device with aerobic and resistance exercise capability in the spaceflight analog of bed rest (BR). METHODS: Subjects (n=34) completed 70 days of 6° head down tilt BR: 9 were randomized to remain sedentary (CONT), 9 to exercise training using traditional equipment (EX), 8 to exercise using traditional equipment and low dose testosterone supplementation (ExT), and 8 to exercise using a combined resistance and aerobic flywheel device (FLY)...
March 26, 2018: Medicine and Science in Sports and Exercise
Evan Sehn, Cassidy Mozak, Nese Yuksel, Cheryl A Sadowski
OBJECTIVE: To describe the quality of online information on testosterone replacement therapy (TRT) in men. METHODS: A quantitative content analysis was conducted on websites providing patient-directed information on TRT for the purpose of treating late onset hypogonadism (LOH). Websites were identified through Google in March 2017. The DISCERN instrument was used to determine the quality of health information. RESULTS: A total of 20 websites met inclusion criteria...
June 20, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Koichi Yabiku, Keiko Nakamoto, Akihiro Tokushige
BACKGROUND: Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentrations of testosterone have been found to inhibit the development of arteriosclerosis, obesity and diabetes. However, these findings have not been verified by testosterone replacement in animal models and whether or not testosterone acts directly by activating AR to enhance leptin signaling, or indirectly by its conversion into estrogen remains unclear...
June 13, 2018: BMC Endocrine Disorders
Blair Crewther, Konrad Witek, Piotr Zmijewski, Zbigniew Obmiński
D-aspartic acid (DAA) is promoted as a testosterone (T) enhancing supplement via mechanisms involving the hypothalamic-pituitary-gonadal (HPG) axis. Here we investigated the short-term effects of DAA on serum biomarkers of the HPG-axis in male climbers. Using a single-blinded, placebo-controlled design, 16 climbers were randomly assigned to either a DAA (3 g·d-1 ) or placebo (3 g·d-1 ) supplement for two weeks. The reverse treatment commenced after a two-week washout, with all conditions administered in a balanced manner...
June 12, 2018: International Journal of Sport Nutrition and Exercise Metabolism
Yi-Chun Lin, Chih-Hsien Chiu, Hung-Chang Liu, Jyun-Yuan Wang
Although curcumin was widely applied as a functional food for different diseases, it was found to reduce serum testosterone level and fertility in male animals by unknown molecular mechanisms. Here in our study, we investigated the possible mechanisms of curcumin-suppressed testosterone production in Leydig cells. Our enzyme immunoassay results showed that curcumin cell-autonomously suppressed ovine luteinizing hormone-stimulated testosterone production in primary Leydig cells and 8-bromo-cyclic adenosine monophosphate (8-br-cAMP)-induced progesterone production in MA-10 cells...
June 9, 2018: Endocrine Journal
Mehri Jamilian, Mansooreh Samimi, Naghmeh Mirhosseini, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Rezavan Talaee, Sadegh Jafarnejad, Shahrzad Hashemi Dizaji, Zatollah Asemi
OBJECTIVE: The aim of this study was to evaluate the effect of the co-administration of vitamin D and omega-3 fatty acid on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome (PCOS). METHODS: This randomized, double-blinded, placebo-controlled clinical trial was conducted on 60 subjects, aged 18-40 years old with PCOS. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 2000 mg/day omega-3 fatty acid from fish oil (n = 30) or placebo (n = 30) for 12 weeks...
May 26, 2018: Journal of Affective Disorders
Tinna Traustadóttir, S Mitchell Harman, Panayiotis Tsitouras, Karol M Pencina, Zhuoying Li, Thomas G Travison, Richard Eder, Renee Miciek, Jennifer McKinnon, Erin Woodbury, Shehzad Basaria, Shalender Bhasin, Thomas W Storer
Context: Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity (V˙O2peak) in healthy older men with low testosterone have not been evaluated. Objective: To determine the effects of testosterone supplementation on V˙O2peak during incremental cycle ergometry. Design: Testosterone's Effects on Atherosclerosis Progression in Aging Men trial: double-blind, randomized, placebo-controlled, parallel-group trial...
May 25, 2018: Journal of Clinical Endocrinology and Metabolism
Seul Min Choi, Duck Soo Lim, Min Kook Kim, Sungpil Yoon, Sam Kacew, Hyung Sik Kim, Byung-Mu Lee
The endocrine disrupting actions of di(2-ethylhexyl) phthalate (DEHP) on testicular functions are postulated to involve excess free radical generation. Thus the aim of this study was to examine the ability of antioxidant vitamins C and E to prevent DEHP-induced testicular disruption in male Sprague-Dawley (SD) rats. SD male rats were administered DEHP alone or DEHP with vitamin C and/or vitamin E for 30 days. DEHP alone increased the levels of testosterone (T) and reduced estradiol (E2 ) concentrations. Supplementation with antioxidant vitamins diminished or restored serum T levels noted in DEHP-treated rats to control values...
May 29, 2018: Journal of Toxicology and Environmental Health. Part A
C Mary Schooling, Shan Luo, Shiu Lun Au Yeung, Deborah J Thompson, Savita Karthikeyan, Thomas R Bolton, Amy M Mason, Erik Ingelsson, Stephen Burgess
BACKGROUND: Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. The causal role of testosterone can be investigated using a Mendelian randomization approach. METHODS AND RESULTS: We assessed genetic associations of variants in two gene regions (SHBG and JMJD1C) with several cardiovascular risk factors (lipids, adiponectin, blood pressure, anthropometric traits) plus male pattern baldness, including control outcomes and potential mediators...
September 15, 2018: International Journal of Cardiology
Nicolas Collongues, Christine Patte-Mensah, Jérôme De Seze, Ayikoe-Guy Mensah-Nyagan, Tobias Derfuss
Neuroprotection and remyelination are two unmet needs in the treatment of multiple sclerosis (MS). Therapeutic potential has been identified with sexual hormones, supported in women by a decrease in MS activity during the pregnancy, in men by a greater severity of symptoms and a faster progression than in women. Areas covered: The therapeutic effect of testosterone and estrogens is reviewed. Both hormones have demonstrated an anti-inflammatory effect. Testosterone has an effect in protecting neurons in culture against glutamate-induced toxicity and oxidative stress, and stimulates myelin formation and regeneration mediated through the neural androgen receptor...
June 2018: Expert Review of Neurotherapeutics
Nikhil S Bhandarkar, Senthil Arun Kumar, Jarad Martin, Lindsay Brown, Sunil K Panchal
Inducing testosterone deficiency, as the standard treatment of prostate cancer, may cause metabolic disorders including insulin resistance, dyslipidemia, central obesity, cardiovascular diseases, and type 2 diabetes. This study measured responses to testosterone deficiency in high-carbohydrate, high-fat (H) diet-fed rats. We then tested whether eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) ethyl esters (Omacor) reversed these metabolic changes. Male Wistar rats (8⁻9 weeks old) were divided into eight groups with four groups fed corn starch and four groups fed H diet...
May 24, 2018: Marine Drugs
Seema Srivastava, Priya Gupta
The aim of the study was to evaluate the effect of Bisphenol A [BPA] widely used as a plasticizer in the formation of polycarbonate plastics and epoxy resins, exposure causing alteration in apoptosis rate, and protective effect of Vitamin E when supplemented with BPA orally. Adult male Wistar albino rats aged 3 months were randomly divided into seven groups: control (olive oil treated) BPA-treated (dose 5, 50,100 μg/100gmBW) and Vitamin E intervention group (dose 5, 50, 100 μg/100gmBW BPA+ Vitamin E dose 4 mg/100gmBW)...
May 21, 2018: Environmental Science and Pollution Research International
Islam M Saadeldin, Mohamed A Hussein, Aida Hamid Suleiman, Mahmoud G Abohassan, Mona M Ahmed, Amr A Moustafa, Abdullah F Moumen, Ayman Abdel-Aziz Swelum
Phthalates (such as DEHP) and bisphenol A (BPA) are widely used chemicals in plastics manufacturing and exert public health concerns as endocrine disrupters. This study was designed to investigate the deleterious effect of DEHP and BPA on endocrine profile of pregnant female rats and the combined treatment with ginseng extract (Panax ginseng). Seventy-two pregnant rats were divided into six groups (control, ginseng, DEHP, BPA, Gin + DEHP, and Gin + BPA), 12 females per each group. The drugs were supplemented from pregnancy day 0 until day 20...
May 18, 2018: Environmental Science and Pollution Research International
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