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https://www.readbyqxmd.com/read/28722077/invasive-haemodynamic-evaluation-of-the-pulmonary-circulation-in-pulmonary-hypertension
#1
Alberto Pagnamenta, Andrea Azzola, Maurice Beghetti, Frédéric Lador, On Behalf Of The Swiss Society Of Pulmonary Hypertension
The term pulmonary hypertension refers to a serious condition characterised by high pulmonary vascular pressure, mainly as a consequence of various cardiac and respiratory diseases. Current clinical classification of pulmonary hypertension considers five distinct groups. Transthoracic echocardiography represents the first and most important noninvasive screening tool for estimating the probability of pulmonary hypertension. The diagnostic approach to pulmonary hypertension is supported by a proposed algorithm, which identifies the underlying cause...
July 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28717911/laparoscopic-compared-to-open-repeat-hepatectomy-for-colorectal-liver-metastases-a-multi-institutional-propensity-matched-analysis-of-short-and-long-term-outcomes
#2
Julie Hallet, Antonio Sa Cunha, Daniel Cherqui, Brice Gayet, Diane Goéré, Philippe Bachellier, Alexis Laurent, David Fuks, Francis Navarro, Patrick Pessaux
INTRODUCTION: While uptake of laparoscopic hepatectomy has improved, evidence on laparoscopic re-hepatectomy (LRH) for colorectal liver metastases (CRLMs) is limited and has never been compared to the open approach. We sought to define outcomes of LRH compared to open re-hepatectomy (ORH). METHODS: Patients undergoing re-hepatectomy for CRLM at 39 institutions (2006-2013) were identified. Primary outcomes were 30-day post-operative overall morbidity, mortality, and length of stay...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28708196/assessment-of-mitral-apparatus-in-patients-with-acute-inferoposterior-myocardial-infarction-and-ischaemic-mitral-regurgitation-with-two-dimensional-echocardiography-from-anatomically-correct-imaging-planes
#3
Karolina Mėlinytė, Živile Valuckiene, Renaldas Jurkevičius
BACKGROUND: Ischaemic mitral regurgitation (IMR) is associated with adverse prognosis after myocardial infarction (MI) as a result of left ventricular remodelling and geometric deformation of the mitral apparatus (MA). AIM: The aim of this study was to assess MA from anatomically correct imaging planes in acute inferoposterior MI and IMR. METHODS: Ninety-three patients with no structural cardiac valve abnormalities and the first acute inferoposterior MI were prospectively enrolled into the study...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28707261/from-inflammation-to-fibrosis-molecular-and-cellular-mechanisms-of-myocardial-tissue-remodelling-and-perspectives-on-differential-treatment-opportunities
#4
REVIEW
Navin Suthahar, Wouter C Meijers, Herman H W Silljé, Rudolf A de Boer
PURPOSE OF REVIEW: In this review, we highlight the most important cellular and molecular mechanisms that contribute to cardiac inflammation and fibrosis. We also discuss the interplay between inflammation and fibrosis in various precursors of heart failure (HF) and how such mechanisms can contribute to myocardial tissue remodelling and development of HF. RECENT FINDINGS: Recently, many research articles attempt to elucidate different aspects of the interplay between inflammation and fibrosis...
July 13, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28706743/when-is-the-optimal-timing-of-surgical-intervention-for-severe-functional-tricuspid-regurgitation
#5
Nobuhiro Nakanishi, Masanobu Ishii, Koichi Kaikita, Ken Okamoto, Yasuhiro Izumiya, Eiichiro Yamamoto, Seiji Takashio, Seiji Hokimoto, Toshihiro Fukui, Kenichi Tsujita
Functional tricuspid regurgitation (TR) is a serious pathology to be noted for severe right heart failure (HF) and poor prognosis; however, the conventional assessment of TR has some limitations and the optimal timing of surgical intervention remains unclear. A 79-year-old Japanese female was admitted to our hospital to undergo cardiac surgery, because edema gradually got worse despite the increase in diuretics. She had a history of atrial fibrillation (AF) and chronic HF due to severe TR and had been treated with a furosemide for leg edema 4 years ago...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28702857/protein-kinase-c-and-cardiac-dysfunction-a-review
#6
REVIEW
Raphael M Singh, Emanuel Cummings, Constantinos Pantos, Jaipaul Singh
Heart failure (HF) is a physiological state in which cardiac output is insufficient to meet the needs of the body. It is a clinical syndrome characterized by impaired ability of the left ventricle to either fill or eject blood efficiently. HF is a disease of multiple aetiologies leading to progressive cardiac dysfunction and it is the leading cause of deaths in both developed and developing countries. HF is responsible for about 73,000 deaths in the UK each year. In the USA, HF affects 5.8 million people and 550,000 new cases are diagnosed annually...
July 12, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28702757/mental-distress-factors-and-exercise-capacity-in-patients-with-coronary-artery-disease-attending-cardiac-rehabilitation-program
#7
Nijole Kazukauskiene, Julius Burkauskas, Jurate Macijauskiene, Inga Duoneliene, Vaidute Gelziniene, Vilija Jakumaite, Julija Brozaitiene
PURPOSE: There is still insufficient data on mental distress factors contributing to exercise capacity (EC) improvement before and after cardiac rehabilitation (CR) in patients with coronary artery disease (CAD). The aim of our study was to evaluate the associations between various mental distress factors and EC before and after exercise-based CR (EBCR). METHODS: Over 12 months, 223 CAD patients (70% men, mean age 58 ± 9 years) were evaluated for socio-demographic, clinical, and mental distress symptoms as measured by the Hospital Anxiety and Depression scale (HADS), Beck Depression Inventory-II (BDI-II), and Spielberger State-Trait Anxiety Inventory (STAI)...
July 12, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28701611/the-utility-of-targeted-perioperative-transthoracic-echocardiography-in-managing-an-adult-patient-with-anomalous-origin-of-the-left-coronary-artery-pulmonary-artery-for-noncardiac-surgery
#8
Anudeep Jafra, Suman Arora, Aveek Jayant
Congenital coronary artery anomalies as a whole are uncommon. Abnormal origin of the left coronary artery from the pulmonary artery (ALCAPA) is probably the most common congenital coronary defect. An overwhelming majority of the patients with untreated ALCAPA do not survive to adulthood. As yet, there is no consensus on the management of adults with ALCAPA. We describe a patient with breast malignancy and incidentally detected ALCAPA; primacy was given to treatment of the oncologic condition as a first step...
July 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28698762/congenital-progressive-mutilating-hemangioma
#9
Anastasiya Chokoeva, Radica Sokolova, Torello Lotti, Uwe Wollina, Serena Gianfaldoni, Jacopo Lotti, Katlein França, Georgi Tchernev
A 73-year-old male patient was admitted with symptoms of decompensated cardiac and pulmonary insufficiency with long-lasting history. A tumor-like formation was observed within the clinical examination, covering the whole skin of the nose, paranasal region of the left part of the face, as well as the upper and lower left eyelids. The lesion was with yellow to brownish surface and dark-reddish to violet discolored peripheral area, composed of nodular formations, smooth central surface and firm texture on palpation...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28695336/experimentally-induced-intrauterine-growth-restriction-in-rabbits-leads-to-differential-remodelling-of-left-versus-right-ventricular-myocardial-microstructure
#10
Julia Schipke, Anna Gonzalez-Tendero, Lidia Cornejo, Alper Willführ, Bart Bijnens, Fatima Crispi, Christian Mühlfeld, Eduard Gratacós
Intrauterine growth restriction (IUGR) is associated with foetal cardiac remodelling and dysfunction together with increased risk of cardiovascular disease in adulthood. Experimental data concerning effects of IUGR on cardiomyocyte and microvascularization anatomy are inconsistent and it is unknown whether both ventricles are similarly susceptible to in utero undersupply. Foetal IUGR was induced in pregnant rabbits at 25 days of gestation by selective ligation of uteroplacental vessels. Foetal echocardiography showed systolic and diastolic dysfunction of both ventricles and body and heart weight were significantly reduced in response to IUGR...
July 10, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28690994/delayed-diagnosis-of-22q11-deletion-syndrome-due-to-late-onset-hypocalcemia-in-a-11-year-old-girl-with-imperforated-anus
#11
Dong-Yoon Yoo, Hae Jung Kim, Kee Hyun Cho, Eun Byul Kwon, Eun-Gyong Yoo
Neonatal hypocalcemia and congenital heart defects has been known as the first clinical manifestation of the chromosome 22q11.2 deletion syndrome (22q11DS). However, because of its wide clinical spectrum, diagnosis of 22q11DS can be delayed in children without classic symptoms. We report the case of a girl with the history of imperforate anus but without neonatal hypocalcemia or major cardiac anomaly, who was diagnosed for 22q11DS at the age of 11 after the onset of overt hypocalcemia. She was born uneventfully from phenotypically normal Korean parents...
June 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/28686688/therapeutic-impact-of-dietary-vitamin-d-supplementation-for-preventing-right-ventricular-remodeling-and-improving-survival-in-pulmonary-hypertension
#12
Hiroaki Tanaka, Masaharu Kataoka, Sarasa Isobe, Tsunehisa Yamamoto, Kohsuke Shirakawa, Jin Endo, Toru Satoh, Yoji Hakamata, Eiji Kobayashi, Motoaki Sano, Keiichi Fukuda
BACKGROUND: Pulmonary hypertension (PH), caused by elevated pulmonary vascular resistance, leads to right heart failure and ultimately death. Vitamin D deficiency can predispose individuals to hypertension and left ventricular dysfunction; however, it remains unknown how serum vitamin D level is related to PH and right ventricular (RV) dysfunction. METHODS: Serum 25-hydroxyvitamin D [25(OH)D] levels were assessed in PH patients for an association with disease severity...
2017: PloS One
https://www.readbyqxmd.com/read/28685393/side-effects-of-long-term-continuous-intra-arterial-nimodipine-infusion-in-patients-with-severe-refractory-cerebral-vasospasm-after-subarachnoid-hemorrhage
#13
Martin Kieninger, Julia Flessa, Nicole Lindenberg, Sylvia Bele, Andreas Redel, André Schneiker, Gerhard Schuierer, Christina Wendl, Bernhard Graf, Vera Silbereisen
BACKGROUND: Long-term continuous intra-arterial nimodipine infusion (CIAN) is a rescue therapy option in cases of severe refractory cerebral vasospasm (CV) following acute non-traumatic subarachnoid hemorrhage (SAH). However, CIAN therapy can be associated with relevant side effects. Available studies focus on intracerebral complications, whereas extracerebral side effects are rarely examined. Aim of the present study was to generate descriptive data on the clinical course during CIAN therapy and expectable extracerebral side effects...
July 6, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28685207/clinical-effects-of-long-term-cardiac-contractility-modulation-ccm-in-subjects-with-heart-failure-caused-by-left-ventricular-systolic-dysfunction
#14
D Müller, A Remppis, P Schauerte, S Schmidt-Schweda, D Burkhoff, B Rousso, D Gutterman, J Senges, G Hindricks, K-H Kuck
INTRODUCTION: Heart failure is a major cause of morbidity and mortality throughout the world. Despite advances in therapy, nearly half of patients receiving guideline-directed medical therapy remain limited by symptoms. Cardiac contractility modulation (CCM) can improve symptoms in this population, but efficacy and safety in prospective studies has been limited to 12 months of follow-up. We report on the first 2 year multi-site evaluation of CCM in patients with heart failure. METHODS: One hundred and forty-three subjects with heart failure and reduced ejection fraction were followed via clinical registry for 24 months recording NYHA class, MLWHFQ score, 6 min walk distance, LVEF, and peak VO2 at baseline and 6 month intervals as clinically indicated...
July 6, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28682147/predictors-of-future-arrhythmic-events-in-patients-with-unexplained-syncope
#15
Dirk Prochnau, Tobias Lambert, Holger Sigusch, Ralf Surber, Paul Christian Schulze
AIMS: The purpose of this study was to examine the usefulness of implantable loop recorders (ILRs) for symptom-rhythm correlation and to identify predictors of future arrhythmic events. PATIENTS AND METHODS: In our dual-centre study, we analysed ILR data of 189 patients (mean age 67.4 ± 15.2 years, 114 male) with unexplained syncope (single syncope 21 patients, recurrent 168 patients, traumatic injury 43 patients). Patients had severe comorbidities such as hypertension (n = 127), coronary artery disease (n = 31), diabetes mellitus (n = 33) and chronic renal insufficiency (n = 18)...
July 6, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28681507/correlation-between-herg-channel-inhibition-and-action-potential-prolongation
#16
P Saxena, M P Hortigon-Vinagre, S Beyl, I Baburin, S Andranovits, S M Iqbal, A Costa, A P IJzerman, P Kügler, E Timin, G L Smith, S Hering
BACKGROUND AND PURPOSE: hERG (Kv11.1) channel inhibition is a widely accepted predictor of cardiac arrhythmia. hERG channel inhibition alone is often insufficient to predict pro-arrhythmic drug effects. This study used a library of dofetilide derivatives to investigate the relationship between standard measures of hERG current block in an expression system and changes in action potential duration (APD) in hiPSC-CMs. The interference from accompanying block of Cav1.2 and Nav1.5 channels was investigated along with an in-silico action potential (AP) model...
July 6, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28679680/chronic-hypoxia-alters-maternal-uterine-and-fetal-hemodynamics-in-the-term-pregnant-guinea-pig
#17
Shifa Turan, Graham W Aberdeen, Loren P Thompson
Placental hypoxia is associated with maternal hypertension, placental insufficiency and fetal growth restriction. In the pregnant guinea pig, prenatal hypoxia during early gestation inhibits cytotrophoblast invasion of spiral arteries, increases maternal blood pressure and induces fetal growth restriction. This study evaluated the impact of chronic maternal hypoxia on fetal heart structure with 4D echocardiography with spatio-temporal image correlation and tomographic ultrasound (STIC-TUI) and uterine and umbilical artery resistance/pulsatility indices and fetal heart function using pulsed wave Doppler ultrasound...
July 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28679323/the-apparent-diffusion-coefficient-is-strongly-correlated-with-extracellular-volume-a-measure-of-myocardial-fibrosis-and-subclinical-cardiomyopathy-in-patients-with-systemic-lupus-erythematosus
#18
Rui Wu, Dong-Aolei An, Jiani Hu, Meng Jiang, Qiang Guo, Jian-Rong Xu, Lian-Ming Wu
Background Extracellular volume (ECV) has been histologically validated as a non-invasive quantitative index of myocardial fibrosis that does not require the use of contrast, which is contraindicated in patients with renal insufficiency. Purpose To evaluate the correlation between the contrast-free apparent diffusion coefficient (ADC) and ECV, an index of fibrosis. Material and Methods Twenty-four patients with systemic lupus erythematosus (SLE), who were predominantly women (mean age = 36 ± 12 years) and 12 normal participants (mean age = 38 ± 10 years) underwent cardiac magnetic resonance (CMR) via 3...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28678037/sporadic-late-onset-nemaline-myopathy-with-monoclonal-gammopathy-of-undetermined-significance
#19
Akinori Uruha, Olivier Benveniste
PURPOSE OF REVIEW: Sporadic late-onset nemaline myopathy (SLONM) with monoclonal gammopathy of undetermined significance (MGUS) is a rare subacute progressive muscle disease. The prognosis is poor due to severe respiratory insufficiency. Recently, however, autologous stem-cell transplantation following high-dose melphalan has been shown to be effective unless there is delay before the treatment. Therefore, early recognition of the disease is important. This review gives an overview of recent advances about SLONM-MGUS, which could help to understand clinical and pathological features and treatment...
July 3, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28677944/heart-rate-response-and-recovery-in-wheelchair-tetraplegic-rugby-athletes-a-pilot-study
#20
Michelle C Coutinho, Patrícia S Vigário, Agnaldo J Lopes, Fernando S Guimarães
BACKGROUND: Subjects with spinal cord injuries (SCI) have impaired autonomic cardiac regulation and increased risk of cardiovascular disease. In face of the insufficient research data on the autonomic control of physically active subjects with SCI, this study aimed at describing the chronotropic response, as well as the heart rate recovery behaviour of a cohort of elite wheelchair rugby athletes. METHODS: This is a cross-sectional study including a convenience sample of 17 elite wheelchair rugby athletes with tetraplegia...
July 5, 2017: Journal of Sports Medicine and Physical Fitness
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