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Implementation science

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https://www.readbyqxmd.com/read/28429989/personalized-medicine-what-are-the-challenges-for-health-services
#1
Walter Ricciardi
Genetics and genomics, together with other biomedical sciences and digital technologies, have a vital role to play in transforming health services to become systems that can work for health in the 21st century in ways that are affordable and that respond to individuals' requirement for more autonomy. Health services should embrace this agenda and implement changes in the organization of care.
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/28428874/population-assessment-using-multivariate-time-series-analysis-a-case-study-of-rockfishes-in-puget-sound
#2
Nick Tolimieri, Elizabeth E Holmes, Gregory D Williams, Robert Pacunski, Dayv Lowry
Estimating a population's growth rate and year-to-year variance is a key component of population viability analysis (PVA). However, standard PVA methods require time series of counts obtained using consistent survey methods over many years. In addition, it can be difficult to separate observation and process variance, which is critical for PVA. Time-series analysis performed with multivariate autoregressive state-space (MARSS) models is a flexible statistical framework that allows one to address many of these limitations...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28425568/libkedf-an-accelerated-library-of-kinetic-energy-density-functionals
#3
Johannes M Dieterich, William C Witt, Emily A Carter
Kinetic energy density functionals (KEDFs) approximate the kinetic energy of a system of electrons directly from its electron density. They are used in electronic structure methods that lack direct access to orbitals, for example, orbital-free density functional theory (OFDFT) and certain embedding schemes. In this contribution, we introduce libKEDF, an accelerated library of modern KEDF implementations that emphasizes nonlocal KEDFs. We discuss implementation details and assess the performance of the KEDF implementations for large numbers of atoms...
April 20, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28424768/model-based-policymaking-a-framework-to-promote-ethical-good-practice-in-mathematical-modeling-for-public-health-policymaking
#4
Lisa A Boden, Iain J McKendrick
Mathematical models are increasingly relied upon as decision support tools, which estimate risks and generate recommendations to underpin public health policies. However, there are no formal agreements about what constitutes professional competencies or duties in mathematical modeling for public health. In this article, we propose a framework to evaluate whether mathematical models that assess human and animal disease risks and control strategies meet standards consistent with ethical "good practice" and are thus "fit for purpose" as evidence in support of policy...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28420455/nutrient-profiling-for-product-reformulation-public-health-impact-and-benefits-for-the-consumer
#5
Undine Lehmann, Véronique Rheiner Charles, Antonis Vlassopoulos, Gabriel Masset, Jörg Spieldenner
The food industry holds great potential for driving consumers to adopt healthy food choices as (re)formulation of foods can improve the nutritional quality of these foods. Reformulation has been identified as a cost-effective intervention in addressing non-communicable diseases as it does not require significant alterations of consumer behaviour and dietary habits. Nutrient profiling (NP), the science of categorizing foods based on their nutrient composition, has emerged as an essential tool and is implemented through many different profiling systems to guide reformulation and other nutrition policies...
April 19, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28420357/in-search-of-quality-indicators-for-down-syndrome-healthcare-a-scoping-review
#6
Francine A van den Driessen Mareeuw, Mirjam I Hollegien, Antonia M W Coppus, Diana M J Delnoij, Esther de Vries
BACKGROUND: The medical care chain around Down syndrome (DS) is complex, with many multidisciplinary challenges. The current quality of care is unknown. Outcome-oriented quality indicators have the potential to improve medical practice and evaluate whether innovations are successful. This is particularly interesting for the evolving care for people with DS and intellectual disabilities (ID). The aim of this study was to identify existing indicators for medical DS care, by reviewing the literature...
April 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28420265/ichampss-usability-and-psychosocial-impact-for-increasing-implementation-of-sexual-health-education
#7
Belinda F Hernandez, Melissa F Peskin, Ross Shegog, Efrat K Gabay, Paula M Cuccaro, Robert C Addy, Eric Ratliff, Susan T Emery, Christine M Markham
INTRODUCTION: Diffusion of sexual health evidence-based programs (EBPs) in schools is a complex and challenging process. iCHAMPSS ( CHoosing And Maintaining effective Programs for Sex education in Schools) is an innovative theory- and Web-based decision support system that may help facilitate this process. The purpose of this study was to pilot-test iCHAMPSS for usability and short-term psychosocial impact. METHOD: School district stakeholders from across Texas were recruited ( N = 16) and given access to iCHAMPSS for 3 weeks in fall 2014...
May 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28419432/a-global-synthesis-of-managing-groundwater-dependent-ecosystems-under-sustainable-groundwater-policy
#8
Melissa M Rohde, Ray Froend, Jeanette Howard
Groundwater is a vital water supply worldwide for people and nature. However, species and ecosystems that depend on groundwater for some or all of their water needs, known as groundwater dependent ecosystems (GDEs), are increasingly becoming threatened worldwide due to growing human water demands. Over the past two decades, the protection and management of GDEs have been incorporated into several water management policy initiatives worldwide including jurisdictions within Australia, the European Union, South Africa, and the United States...
April 17, 2017: Ground Water
https://www.readbyqxmd.com/read/28419084/neonatal-resuscitation-in-global-health-settings-an-examination-of-the-past-to-prepare-for-the-future
#9
REVIEW
Beena D Kamath-Rayne, Sara K Berkelhamer, K C Ashish, Hege L Ersdal, Susan Niermeyer
BACKGROUND: As rates of childhood mortality decline, neonatal deaths account for nearly half of under-5 deaths worldwide. Intrapartum-related events (birth asphyxia) contribute to approximately one-quarter of neonatal deaths, many of which can be prevented by simple resuscitation and newborn care interventions. METHODS: This paper reviews various lines of research that have influenced the global neonatal resuscitation landscape. A brief situational analysis of asphyxia-related newborn mortality in low-resource settings is linked to renewed efforts to reduce neonatal mortality in the Every Newborn Action Plan...
April 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28418987/the-roles-of-behavioral-and-social-science-research-in-the-fight-against-hiv-aids-a-functional-framework
#10
Paul Gaist, Michael J Stirratt
Landmark advances have been made in HIV/AIDS prevention and treatment. These include proof-of-concept and public health implementation of pre-exposure prophylaxis (PrEP) and "treatment as prevention" (TasP) to reduce HIV transmission as well as definitive evidence of the clinical gain from early antiretroviral treatment (ART) initiation. Significant progress has been made in understanding and addressing the social contexts and behavioral factors that impact HIV prevention, care, and treatment interventions...
April 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28417159/endangered-mangroves-in-segara-anakan-indonesia-effective-and-failed-problem-solving-policy-advice
#11
Budi Dharmawan, Michael Böcher, Max Krott
The success of scientific knowledge transfer depends on if the decision maker can transform the scientific advice into a policy that can be accepted by all involved actors. We use a science-policy interactions model called research-integration-utilization to observe the process of scientific knowledge transfer in the case of endangered mangroves in Segara Anakan, Indonesia. Scientific knowledge is produced within the scientific system (research), science-based solutions to problems are practically utilized by political actors (utilization), and important links between research and utilization must be made (integration)...
April 17, 2017: Environmental Management
https://www.readbyqxmd.com/read/28416022/specific-or-general-exercise-strategy-for-subacromial-impingement-syndrome-does-it-matter-a-systematic-literature-review-and-meta-analysis
#12
Alison R Shire, Thor A B Stæhr, Jesper B Overby, Mathias Bastholm Dahl, Julie Sandell Jacobsen, David Høyrup Christiansen
BACKGROUND: Exercise is frequently suggested as a treatment option for patients presenting with symptoms of subacromial impingement syndrome. Some would argue implementing a specific exercise strategy with special focus on correction of kinematic deficits would be superior to general exercise strategy. There is however a lack of evidence comparing such exercise strategies to determine which is the most effective in the treatment of subacromial impingement syndrome. The aim of this review is to evaluate whether implementing specific exercise strategies involving resistive exercises are more effective than a general exercise strategy for the treatment of patients with subacromial impingement syndrome...
April 17, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28416020/patient-and-family-centered-performance-measures-focused-on-actionable-processes-of-care-for-persistent-and-chronic-critical-illness-protocol-for-a-systematic-review
#13
Louise Rose, Laura Istanboulian, Laura Allum, Lisa Burry, Craig Dale, Nicholas Hart, Claire Kydonaki, Pam Ramsay, Natalie Pattison, Bronwen Connolly
BACKGROUND: Approximately 5 to 10% of critically ill patients transition from acute critical illness to a state of persistent and in some cases chronic critical illness. These patients have unique and complex needs that require a change in the clinical management plan and overall goals of care to a focus on rehabilitation, symptom relief, discharge planning, and in some cases, end-of-life care. However, existing indicators and measures of care quality, and tools such as checklists, that foster implementation of best practices, may not be sufficiently inclusive in terms of actionable processes of care relevant to these patients...
April 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28415881/hip-and-pelvic-fracture-patients-with-fear-of-falling-development-and-description-of-the-step-by-step-treatment-protocol
#14
Karin Kampe, Michaela Kohler, Diana Albrecht, Clemens Becker, Martin Hautzinger, Ulrich Lindemann, Klaus Pfeiffer
OBJECTIVE: Based on a theoretical framework and sound evidence, this article describes a rehabilitation programme for patients with fear of falling after hip and pelvic fracture. RATIONALE: Based on exercise science principles, current knowledge from fall prevention, emotion regulation, and the Health Action Process Approach we developed a theoretical framework, from which the components of the intervention were derived. Description of the intervention: The intervention consists of 6 components: (1) relaxation, (2) meaningful activities and mobility-based goals, (3) falls related cognitions and emotions, coping with high risk tasks and situations, (4) individual exercise programme, (5) planning and implementing exercises and activities, and (6) fall risks and hazards...
May 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28414848/-abstract-bodies-concrete-risks-clinical-devices-and-the-health-of-ova-donors-in-argentine-reproductive-medicine
#15
Lucía Ariza
Using a methodological perspective grounded in science and technology studies, this article analyzes two sociotechnical devices used in Argentine reproductive medicine (biostatistical measures and donation registries) with the aim of controlling both the so-called "genetic risk" arising from the use of donated ova as well as the health risks to female donors. By examining how the deployment of monitoring criteria disregards the specificity of ova donation, the article suggests that it is not the absence of control measures and clinical criteria that produces an inadequate monitoring of such risks, but rather the concrete ways in which such measures are implemented that results in potential harms to the health of female donors...
July 2016: Salud Colectiva
https://www.readbyqxmd.com/read/28414712/the-need-for-a-worldwide-consensus-for-cell-line-authentication-experience-implementing-a-mandatory-requirement-at-the-international-journal-of-cancer
#16
Norbert E Fusenig, Amanda Capes-Davis, Franca Bianchini, Sherryl Sundell, Peter Lichter
Cell lines are used in life science research worldwide as biological surrogates. All cell lines are subject to major limitations when used as research tools, including (i) cross-contamination with other cells cultured in the same laboratory environment and (ii) evolution in vitro that renders a given cell line inappropriate as a surrogate for a specific biological hypothesis. There is ample evidence that cross-contamination or phenotypic drift of cells in culture can generate irreproducible or misleading data...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28414282/-pharmacometabonomics-the-novel-way-to-personalized-drug-therapy
#17
REVIEW
D L Maslov, E E Balashova, P G Lokhov, A I Archakov
The review is devoted to pharmacometabonomics - a new branch of science focused on personalization of drug therapy through the comprehensive analysis of metabolites of patient's biological fluids. It considers the history of pharmacometabonomic, positioning to other "-omic" sciences, and system approach, realized by this science, in determination of individual therapeutic dose of the drugs and also a technical implementation of pharmacometabonomic based on direct mass spectrometry of blood plasma metabolites...
March 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/28413034/preface-optimizing-science-impact-for-effective-implementation-of-sustainable-land-management
#18
EDITORIAL
Joris de Vente, Susana Bautista, Barron Orr
No abstract text is available yet for this article.
June 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28411893/genomic-approaches-to-hypertension
#19
REVIEW
Sheriff N Dodoo, Ivor J Benjamin
Genomic insights and analyses of Mendelian hypertension (HTN) syndromes and Genome-Wide Association study (GWAS) on essential hypertension have contributed to the depth of understanding of the genetics origins of hypertension. Mendelian syndromes are important for the field, since such knowledge leads to specific insights about disease pathogenesis and the potential for precision medicine. The clinical impact of findings of on essential hypertension is continuously evolving, and the insights accrued will refine efforts to combat the societal impact of hypertension...
May 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/28410462/health-service-provision-for-people-with-epilepsy-in-sub-saharan-africa-a-situational-review
#20
REVIEW
Musa M Watila, Mark R Keezer, Samuel A Angwafor, Andrea S Winkler, Josemir W Sander
BACKGROUND: Epilepsy is a public health issue in sub-Saharan Africa (SSA) where many people with the condition receive no treatment. Health-care services for epilepsy in this region have not been comprehensively assessed. We examined key features of epilepsy health services provided in SSA. METHODOLOGY: This was a scoping review conducted using pre-specified protocols. We implemented an electronic search strategy to identify relevant citations using PUBMED, EMBASE, Web of Science, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL), African Index Medicus (AIM), Open Grey, Cochrane database, and Google Scholar...
April 11, 2017: Epilepsy & Behavior: E&B
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