keyword
MENU ▼
Read by QxMD icon Read
search

Implementation science

keyword
https://www.readbyqxmd.com/read/28750104/breps-2-0-optimization-of-sequence-pattern-prediction-for-enzyme-annotation
#1
Christian-Alexander Dudek, Henning Dannheim, Dietmar Schomburg
The prediction of gene functions is crucial for a large number of different life science areas. Faster high throughput sequencing techniques generate more and larger datasets. The manual annotation by classical wet-lab experiments is not suitable for these large amounts of data. We showed earlier that the automatic sequence pattern-based BrEPS protocol, based on manually curated sequences, can be used for the prediction of enzymatic functions of genes. The growing sequence databases provide the opportunity for more reliable patterns, but are also a challenge for the implementation of automatic protocols...
2017: PloS One
https://www.readbyqxmd.com/read/28749925/the-role-of-screening-and-treatment-in-national-progress-toward-hepatitis-c-elimination-georgia-2015-2016
#2
Muazzam Nasrullah, David Sergeenko, Lia Gvinjilia, Amiran Gamkrelidze, Tengiz Tsertsvadze, Maia Butsashvili, David Metreveli, Lali Sharvadze, Maia Alkhazashvili, Shaun Shadaker, John W Ward, Juliette Morgan, Francisco Averhoff
Georgia, a country in the Caucasus region of Eurasia, has a high prevalence of hepatitis C virus (HCV) infection. In April 2015, with technical assistance from CDC, Georgia embarked on the world's first program to eliminate hepatitis C, defined as a 90% reduction in HCV prevalence by 2020 (1,2). The country committed to identifying infected persons and linking them to care and curative antiviral therapy, which was provided free of charge through a partnership with Gilead Sciences (1,2). From April 2015 through December 2016, a total of 27,595 persons initiated treatment for HCV infection, among whom 19,778 (71...
July 28, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28748713/qbd-for-pediatric-oral-lyophilisates-development-risk-assessment-followed-by-screening-and-optimization
#3
Tibor Casian, Sonia Iurian, Catalina Bogdan, Lucia Rus, Mirela Moldovan, Ioan Tomuta
OBJECTIVE: This study proposed the development of oral lyophilisates with respect to pediatric medicine development guidelines, by applying risk management strategies and DoE as an integrated QbD approach. METHODS: Product critical quality attributes were overviewed by generating Ishikawa diagrams for risk assessment purposes, considering process, formulation and methodology related parameters. Failure Mode Effect Analysis was applied to highlight critical formulation and process parameters with an increased probability of occurrence and with a high impact on the product performance...
July 27, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28748176/global-epidemiology-of-dengue-outbreaks-in-1990-2015-a-systematic-review-and-meta-analysis
#4
Congcong Guo, Zixing Zhou, Zihao Wen, Yumei Liu, Chengli Zeng, Di Xiao, Meiling Ou, Yajing Han, Shiqi Huang, Dandan Liu, Xiaohong Ye, Xiaoqian Zou, Jing Wu, Huanyu Wang, Eddy Y Zeng, Chunxia Jing, Guang Yang
Dengue is an arthropod-borne infectious disease caused by dengue virus (DENV) infection and transmitted by Aedes mosquitoes. Approximately 50-100 million people are infected with DENV each year, resulting in a high economic burden on both governments and individuals. Here, we conducted a systematic review and meta-analysis to summarize information regarding the epidemiology, clinical characteristics, and serotype distribution and risk factors for global dengue outbreaks occurring from 1990 to 2015. We searched the PubMed, Embase and Web of Science databases through December 2016 using the term "dengue outbreak...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28747353/effectiveness-of-a-low-cost-graduate-student-led-intervention-on-study-habits-and-performance-in-introductory-biology
#5
Tyler D Hoskins, J D Gantz, Blake R Chaffee, Kel Arlinghaus, James Wiebler, Michael Hughes, Joyce J Fernandes
Institutions have developed diverse approaches that vary in effectiveness and cost to improve student performance in introductory science, technology, engineering, and mathematics courses. We developed a low-cost, graduate student-led, metacognition-based study skills course taught in conjunction with the introductory biology series at Miami University. Our approach aimed to improve performance for underachieving students by combining an existing framework for the process of learning (the study cycle) with concrete tools (outlines and concept maps) that have been shown to encourage deep understanding...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28747274/efficacy-safety-and-effect-on-sexual-behaviour-of-on-demand-pre-exposure-prophylaxis-for-hiv-in-men-who-have-sex-with-men-an-observational-cohort-study
#6
Jean-Michel Molina, Isabelle Charreau, Bruno Spire, Laurent Cotte, Julie Chas, Catherine Capitant, Cecile Tremblay, Daniela Rojas-Castro, Eric Cua, Armelle Pasquet, Camille Bernaud, Claire Pintado, Constance Delaugerre, Luis Sagaon-Teyssier, Soizic Le Mestre, Christian Chidiac, Gilles Pialoux, Diane Ponscarme, Julien Fonsart, David Thompson, Mark A Wainberg, Veronique Doré, Laurence Meyer
BACKGROUND: Data for on-demand pre-exposure prophylaxis (PrEP) are scarce. We implemented a cohort study to assess its efficacy, safety, and effect on sexual behaviour. METHODS: We invited men and transgender women who have sex with men, previously enrolled in the randomised placebo-controlled ANRS IPERGAY trial at seven sites (six in France and one in Canada), to participate in an open-label extension with on-demand tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) to be taken before and after sexual intercourse...
July 21, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28746842/the-droso4schools-project-long-term-scientist-teacher-collaborations-to-promote-science-communication-and-education-in-schools
#7
REVIEW
Sanjai Patel, Sophie DeMaine, Joshua Heafield, Lynne Bianchi, Andreas Prokop
Science communication is becoming an increasingly important part of a scientist's remit, and engaging with primary and secondary schools is one frequently chosen strategy. Here we argue that engaging with schools will be more effective when engaging with teachers through structured participation and/or collaboration, in order to respond to the realities of school life in designing the strategies used by science communicators. For example, the Manchester Fly Facility advocates the fruit fly Drosophila as an important research strategy for the discovery processes in the biomedical sciences...
July 23, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28745551/institutional-profile-of-pharmacogenetics-within-university-of-michigan-college-of-pharmacy
#8
Daniel L Hertz, Jasmine A Luzum, Amy L Pasternak, Kristen M Ward, Hao-Jie Zhu, James M Rae, Vicki L Ellingrod
The University of Michigan College of Pharmacy has made substantial investment in the area of pharmacogenomics to further bolster its activity in pharmacogenomics research, implementation and education. Four tenure-track faculty members have active research programs that focus primarily on the discovery of functional polymorphisms (HJ Zhu), and genetic associations with treatment outcomes in patients with cancer (DL Hertz), cardiovascular disease (JA Luzum) and psychiatric conditions (VL Ellingrod). Recent investments from the University and the College have accelerated the implementation of pharmacogenetics broadly across the institution and in targeted therapeutic areas...
July 26, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28743591/terminology-supported-archiving-and-publication-of-environmental-science-data-in-pangaea-open-access
#9
Michael Diepenbroek, Uwe Schindler, Robert Huber, Stéphane Pesant, Markus Stocker, Janine Felden, Melanie Buss, Matthias Weinrebe
Exemplified on the information system PANGAEA, we describe the application of terminologies for archiving and publishing environmental science data. A Terminology Catalogue (TC) was embedded into the system, with interfaces allowing to replicate and to manually work on terminologies. For data ingest and archiving, we show how the TC can improve structuring and harmonizing lineage and content descriptions of data sets. Key is the conceptualization of measurement and observation types (parameters) and methods, for which we have implemented a basic syntax and rule set...
July 22, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28742819/the-science-of-rapid-start-from-the-when-to-the-how-of-antiretroviral-initiation
#10
Elvin H Geng, Diane V Havlir
In this Perspective linked to Koenig and colleagues, Elvin Geng and Diane Havlir discuss the next challenges for implementation research around rapid start antiretroviral treatment.
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742338/advanced-materials-technologies-and-complex-systems-analyses-emerging-opportunities-to-enhance-urban-water-security
#11
Katherine R Zodrow, Qilin Li, Regina M Buono, Wei Chen, Glenn Daigger, Leonardo Duenas-Osorio, Menachem Elimelech, Xia Huang, Guibin Jiang, Jae-Hong Kim, Bruce E Logan, David L Sedlak, Paul Westerhoff, Pedro J J Alvarez
Innovation in urban water systems is required to address the increasing demand for clean water due to population growth and aggravated water stress caused by water pollution, aging infrastructure, and climate change. Advances in materials science, modular water treatment technologies, and complex systems analyses, coupled with the drive to minimize the energy and environmental footprints of cities, provide new opportunities to ensure a resilient and safe water supply. We present a vision for enhancing efficiency and resiliency of urban water systems and discuss approaches and research needs for overcoming associated implementation challenges...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28741222/network-of-anatomical-texts-nanatex-an-open-source-project-for-visualizing-the-interaction-between-anatomical-terms
#12
Ryusuke Momota, Aiji Ohtsuka
Anatomy is the science and art of understanding the structure of the body and its components in relation to the functions of the whole-body system. Medicine is based on a deep understanding of anatomy, but quite a few introductory-level learners are overwhelmed by the sheer amount of anatomical terminology that must be understood, so they regard anatomy as a dull and dense subject. To help them learn anatomical terms in a more contextual way, we started a new open-source project, the Network of Anatomical Texts (NAnaTex), which visualizes relationships of body components by integrating text-based anatomical information using Cytoscape, a network visualization software platform...
July 24, 2017: Anatomical Science International
https://www.readbyqxmd.com/read/28739489/colonoscopy-and-sigmoidoscopy-use-among-older-adults-in-different-countries-a-systematic-review
#13
REVIEW
Chen Chen, Eileen Läcke, Christian Stock, Michael Hoffmeister, Hermann Brenner
Screening for colorectal cancer (CRC) by colonoscopy and sigmoidoscopy has been demonstrated to be effective in reducing CRC incidence and mortality, and they are increasingly employed as screening tests and for diagnostic purposes in many countries. We conducted a systematic review to provide up-to-date estimates on the utilization of lower gastrointestinal endoscopy (colonoscopy and sigmoidoscopy) in the general average-risk population in different countries. PubMed and Web of Science were searched for relevant articles published between 1 September 2008 and 31 October 2016...
July 21, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28738663/statistical-approach-for-atr-ftir-screening-of-semen-in-sexual-evidence
#14
Inês Gregório, Félix Zapata, Mercedes Torre, Carmen García-Ruiz
Genetic identification has revolutionized the Forensic Sciences, especially in sexual aggression cases. For the successful extraction of the genetic information of a criminal, a crucial step is the prior detection of bodily fluids on evidence. In this article, a method for non-destructive screening of semen samples is reported. Using chemometric tools, bodily fluids can be detected and differentiated without damaging the sample, by correlating the infrared spectra of sexual evidence with previously recorded spectra from undamaged stains of individual bodily fluids...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738203/early-detection-monitoring-for-aquatic-non-indigenous-species-optimizing-surveillance-incorporating-advanced-technologies-and%C3%A2-identifying-research-needs
#15
REVIEW
Anett S Trebitz, Joel C Hoffman, John A Darling, Erik M Pilgrim, John R Kelly, Emily A Brown, W Lindsay Chadderton, Scott P Egan, Erin K Grey, Syed A Hashsham, Katy E Klymus, Andrew R Mahon, Jeffrey L Ram, Martin T Schultz, Carol A Stepien, James C Schardt
Following decades of ecologic and economic impacts from a growing list of nonindigenous and invasive species, government and management entities are committing to systematic early- detection monitoring (EDM). This has reinvigorated investment in the science underpinning such monitoring, as well as the need to convey that science in practical terms to those tasked with EDM implementation. Using the context of nonindigenous species in the North American Great Lakes, this article summarizes the current scientific tools and knowledge - including limitations, research needs, and likely future developments - relevant to various aspects of planning and conducting comprehensive EDM...
July 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28734488/clinical-fellowship-for-an-innovative-integrated-bsn-phd-program-an-academic-and-practice-partnership
#16
Madelyne Z Greene, Mary Kate FitzPatrick, Jean Romano, Linda H Aiken, Therese S Richmond
Opportunities for research-focused doctoral education must be available to nurses early in their careers in order to ensure the further development of nursing science. Early entry into the research doctorate through an integrated BSN-PhD program is one innovative approach. This approach highlights the value of integrating post-licensure clinical training into the doctoral curriculum. To better prepare innovative nurse scientists early in their careers we developed a clinical nurse fellowship within an integrated BSN-PhD program in partnership with an affiliated health system...
July 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28733370/reliable-adherence-to-a-copd-care-bundle-mitigates-system-level-failures-and-reduces-copd-readmissions-a-system-redesign-using-improvement-science
#17
Muhammad Ahsan Zafar, Ralph J Panos, Jonathan Ko, Lisa C Otten, Anthony Gentene, Maria Guido, Katherine Clark, Caroline Lee, Jamie Robertson, Evaline A Alessandrini
BACKGROUND: Readmissions of chronic obstructive pulmonary disease (COPD) have devastating effects on patient quality-of-life, disease progression and healthcare cost. Effective interventions to reduce COPD readmissions are needed. OBJECTIVES: Reduce 30-day all-cause readmissions by (1) creating a COPD care bundle that addresses care delivery failures, (2) using improvement science to achieve 90% bundle adherence. SETTING: An 800-bed academic hospital in Ohio, USA...
July 21, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28730811/atomic-mechanism-of-hybridization-dependent-surface-reconstruction-with-tailored-functionality-in-hexagonal-multiferroics
#18
Shiqing Deng, Shaobo Cheng, Changsong Xu, Binghui Ge, Xuefeng Sun, Rong Yu, Wenhui Duan, Jing Zhu
The broken symmetry along with anomalous defect structures and charging conditions at multiferroics surface can alter both crystal structures and electronic configurations, bringing in emergent physical properties. Extraordinary surface states are induced into original mutually-coupled order parameters in such strongly correlated oxides, which flourish in diverse properties, however remain less explored. Here, we report the peculiar surface ferroelectric states and reconfigurable functionalities driven by the relaxation of surface and consequent changes in O-2p and Y-4d orbital (p-d) hybridization within a representative hexagonal multiferroics YMnO3...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28728997/sepsis-reconsidered-identifying-novel-metrics-for-behavioral-landscape-characterization-with-a-high-performance-computing-implementation-of-an-agent-based-model
#19
Chase Cockrell, Gary An
OBJECTIVES: Sepsis affects nearly 1 million people in the United States per year, has a mortality rate of 28-50% and requires more than $20 billion a year in hospital costs. Over a quarter century of research has not yielded a single reliable diagnostic test or a directed therapeutic agent for sepsis. Central to this insufficiency is the fact that sepsis remains a clinical/physiological diagnosis representing a multitude of molecularly heterogeneous pathological trajectories. Advances in computational capabilities offered by High Performance Computing (HPC) platforms call for an evolution in the investigation of sepsis to attempt to define the boundaries of traditional research (bench, clinical and computational) through the use of computational proxy models...
July 18, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28727962/a-website-system-for-communicating-psychological-science
#20
Ed Diener
The peer review and journal system have shortcomings, and both computers and the Internet have made complementary or alternative systems attractive. In this article, I recommend that we implement a new platform for open communication of psychological science on a dedicated website to complement the current review and journal system, with reader reviews of the articles and with all behavioral scientists being eligible to publish and review articles. The judged merit of articles would be based on the citations and the ratings of the work by the whole scientific community...
July 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
keyword
keyword
11055
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"