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Implementation science

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https://www.readbyqxmd.com/read/28087465/are-cardiovascular-disease-risk-assessment-and-management-programmes-cost-effective-a-systematic-review-of-the-evidence
#1
REVIEW
John Tayu Lee, Kenny D Lawson, Yizhou Wan, Azeem Majeed, Stephen Morris, Michael Soljak, Christopher Millett
The World Health Organization recommends that countries implement population-wide cardiovascular disease (CVD) risk assessment and management programmes. The aim of this study was to conduct a systematic review to evaluate whether this recommendation is supported by cost-effectiveness evidence. Published economic evaluations were identified via electronic medical and social science databases (including Medline, Web of Science, and the NHS Economic Evaluation Database) from inception to March 2016. Study quality was evaluated using a modified version of the Consolidated Health Economic Evaluation Reporting Standards...
January 10, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28080221/molecular-mechanisms-of-antisense-oligonucleotides
#2
Stanley T Crooke
In 1987, when I became interested in the notion of antisense technology, I returned to my roots in RNA biochemistry and began work to understand how oligonucleotides behave in biological systems. Since 1989, my research has focused primarily on this topic, although I have been involved in most areas of research in antisense technology. I believe that the art of excellent science is to frame large important questions that are perhaps not immediately answerable with existing knowledge and methods, and then conceive a long-term (multiyear) research strategy that begins by answering the most pressing answerable questions on the path to the long-term goals...
January 12, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28079898/the-current-state-of-implementation-science-in-genomic-medicine-opportunities-for-improvement
#3
Megan C Roberts, Amy E Kennedy, David A Chambers, Muin J Khoury
PURPOSE: The objective of this study was to identify trends and gaps in the field of implementation science in genomic medicine. METHODS: We conducted a literature review using the Centers for Disease Control and Prevention's Public Health Genomics Knowledge Base to examine the current literature in the field of implementation science in genomic medicine. We selected original research articles based on specific inclusion criteria and then abstracted information about study design, genomic medicine, and implementation outcomes...
January 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28079771/advanced-research-and-data-methods-in-women-s-health-big-data-analytics-adaptive-studies-and-the-road-ahead
#4
Christian R Macedonia, Clark T Johnson, Indika Rajapakse
Technical advances in science have had broad implications in reproductive and women's health care. Recent innovations in population-level data collection and storage have made available an unprecedented amount of data for analysis while computational technology has evolved to permit processing of data previously thought too dense to study. "Big data" is a term used to describe data that are a combination of dramatically greater volume, complexity, and scale. The number of variables in typical big data research can readily be in the thousands, challenging the limits of traditional research methodologies...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28079725/new-medicine-for-the-u-s-health-care-system-training-physicians-for-structural-interventions
#5
Helena Hansen, Jonathan M Metzl
Structural competency provides a language and theoretical framework to promote institutional-level interventions by clinical practitioners working with community organizations, non-health-sector institutions, and policy makers. The special collection of articles on structural competency in this issue of Academic Medicine addresses the need to move from theory to an appraisal of core educational interventions that operationalize the goals of and foster structural competency. In this Commentary, the authors review the role of clinical practitioners in enhancing population-level health outcomes through collaborations with professionals in fields outside medicine, including the social sciences and law...
January 10, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28079592/implementation-science-the-laboratory-as-a-command-centre
#6
Debrah I Boeras, John N Nkengasong, Rosanna W Peeling
PURPOSE OF REVIEW: Recent advances in point-of-care technologies to ensure universal access to affordable quality-assured diagnostics have the potential to transform patient management, surveillance programmes, and control of infectious diseases. Decentralization of testing can put tremendous stresses on fragile health systems if the laboratory is not involved in the planning, introduction, and scale-up strategies. RECENT FINDINGS: The impact of investments in novel technologies can only be realized if these tests are evaluated, adopted, and scaled up within the healthcare system with appropriate planning and understanding of the local contexts in which these technologies will be used...
January 11, 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28079529/leveraging-the-skills-of-nurses-and-the-power-of-language-nutrition-to-ensure-a-better-future-for-children
#7
Ashley Darcy Mahoney, Lauren Head Zauche, Sunny Hallowell, Arianne Weldon, Jennifer Stapel-Wax
BACKGROUND: Early language exposure is critical for language acquisition and significantly influences a child's literacy skills. However, preterm infants may experience language deprivation in the neonatal intensive care unit. Nurses are vital to helping parents understand their critical role in early language development. PURPOSE: To discuss the impact of language-rich interactions and interventions that promote early language exposure, or Language Nutrition, by parents and caregivers on the long-term developmental, language, and educational outcomes of high-risk infants...
January 11, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28078586/study-of-the-cd95-mediated-non-apoptotic-signaling-pathway-pi3k
#8
Amélie Fouqué, Patrick Legembre
CD95 is a plasma membrane receptor that belongs to the TNF receptor family (Itoh and Nagata, J Biol Chem 268(15):10932-10937, 1993; Trauth et al., Science 245(4915):301-305, 1989). Accumulating evidence indicate that this so-called death receptor can also trigger non-apoptotic signaling pathways promoting inflammation and oncogenesis (Barnhart et al., Embo J 23(15):3175-3185, 2004; Chen et al., Nature 465(7297):492-496, 2010; Legembre et al., Cell Cycle 3(10):1235-1239, 2004; Legembre et al., EMBO Rep 5(11):1084-1089, 2004; Malleter et al...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28077935/development-of-a-microarray-based-method-for-allergen-specific-ige-and-igg4-detection
#9
Guzel Feyzkhanova, Sergei Voloshin, Olga Smoldovskaya, Alla Arefieva, Marina Filippova, Viktor Barsky, Ludmila Pavlushkina, Veronika Butvilovskaya, Alexei Tikhonov, Yuri Reznikov, Alla Rubina
BACKGROUND: sIgE and sIgG4 detection is necessary for more accurate and effective type I hypersensitivity diagnostics and the estimation of disease development. Typically, the analyses of these antibodies are performed separately with the help of various specialized systems. The aim of this study was to develop a microarray-based method for the simultaneous quantitative detection of sIgE and sIgG4 to the most common allergens in a single sample. METHODS: A quantitative method for the simultaneous detection of sIgE and sIgG4 was developed based on the technology of hydrogel microchips previously designed at Engelhardt Institute of Molecular Biology, Russian Academy of Sciences (EIMB RAS)...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28077147/the-political-and-scientific-challenges-in-evaluating-compulsory-drug-treatment-centers-in-southeast-asia
#10
Thu Vuong, Nhu Nguyen, Giang Le, Marian Shanahan, Robert Ali, Alison Ritter
BACKGROUND: In Vietnam, like many countries in Southeast Asia, the commonly used approach of center-based compulsory drug treatment (CCT) has been criticized on human rights ground. Meanwhile, community-based voluntary methadone maintenance treatment (MMT) has been implemented for nearly a decade with promising results. Reform-minded leaders have been seeking empirical evidence of the costs and effectiveness associated with these two main treatment modalities. Conducting evaluations of these treatments, especially where randomization is not ethical, presents challenges...
January 11, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28074900/physical-controllability-of-complex-networks
#11
Le-Zhi Wang, Yu-Zhong Chen, Wen-Xu Wang, Ying-Cheng Lai
A challenging problem in network science is to control complex networks. In existing frameworks of structural or exact controllability, the ability to steer a complex network toward any desired state is measured by the minimum number of required driver nodes. However, if we implement actual control by imposing input signals on the minimum set of driver nodes, an unexpected phenomenon arises: due to computational or experimental error there is a great probability that convergence to the final state cannot be achieved...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070261/the-effect-of-utilizing-organizational-culture-improvement-model-of-patient-education-on-coronary-artery-bypass-graft-patients-anxiety-and-satisfaction-theory-testing
#12
Mansoureh Ashghali Farahani, Fatemeh Ghaffari, Faezeh Norouzinezhad, Roohangiz Jamshidi Orak
INTRODUCTION: Due to the increasing prevalence of arteriosclerosis and the mortality caused by this disease, Coronary Artery Bypass Graft (CABG) has become one of the most common surgical procedures. Utilization of patient education is approved as an effective solution for increasing patient survival and outcomes of treatment. However, failure to consider different aspects of patient education has turned this goal into an unattainable one. The objective of this research was to determine the effect of utilizing the organizational culture improvement model of patient education on CABG patients' anxiety and satisfaction...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28069485/alternative-approaches-for-identifying-acute-systemic-toxicity-moving-from-research-to-regulatory-testing
#13
REVIEW
Jon Hamm, Kristie Sullivan, Amy J Clippinger, Judy Strickland, Shannon Bell, Barun Bhhatarai, Bas Blaauboer, Warren Casey, David Dorman, Anna Forsby, Natàlia Garcia-Reyero, Sean Gehen, Rabea Graepel, Jon Hotchkiss, Anna Lowit, Joanna Matheson, Elissa Reaves, Louis Scarano, Catherine Sprankle, Jay Tunkel, Dan Wilson, Menghang Xia, Hao Zhu, David Allen
Acute systemic toxicity testing provides the basis for hazard labeling and risk management of chemicals. A number of international efforts have been directed at identifying non-animal alternatives for in vivo acute systemic toxicity tests. A September 2015 workshop, Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing, reviewed the state-of-the-science of non-animal alternatives for this testing and explored ways to facilitate implementation of alternatives...
January 6, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28068135/the-pediatric-patient-centered-medical-home-innovative-models-for-improving-behavioral-health
#14
Joan Rosenbaum Asarnow, David J Kolko, Jeanne Miranda, Anne E Kazak
This article examines the concept of the Patient-Centered Medical Home (PCMH) as it applies to children and adolescents, emphasizing care for behavioral health conditions, the role of psychology and psychological science, and next steps for developing evidence-informed models for the Pediatric-PCMH. The PCMH concept for pediatric populations offers unique opportunities for psychological science to inform and enhance the transformation of the United States health care system and improve health in our nation...
January 2017: American Psychologist
https://www.readbyqxmd.com/read/28065430/informed-consent-in-dental-care-and-research-for-the-older-adult-population-a-systematic-review
#15
REVIEW
Amrita Mukherjee, Alicia A Livinski, Joseph Millum, Steffany Chamut, Shahdokht Boroumand, Timothy J Iafolla, Margo R Adesanya, Bruce A Dye
BACKGROUND: Ethics in health care and research is based on the fundamental principle of informed consent. However, informed consent in geriatric dentistry is not well documented. Poor health, cognitive decline, and the passive nature of many geriatric patients complicate this issue. METHODS: The authors completed this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The authors searched the PubMed (MEDLINE), Web of Science, PsycINFO, and Cochrane Library databases...
January 5, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28065197/aligning-guidelines-and-medical-practice-literature-review-on-pediatric-palliative-care-guidelines
#16
Eva De Clercq, Michael Rost, Nadia Pacurari, Bernice S Elger, Tenzin Wangmo
OBJECTIVE: Palliative care for children is becoming an important subspecialty of healthcare. Although concurrent administration of curative and palliative care is recommended, timely referral to pediatric palliative care (PPC) services remains problematic. This literature review aims to identify barriers and recommendations for proper implementation of palliative care for children through the looking glass of PPC guidelines. METHOD: To identify studies on PPC guidelines, five databases were searched systematically between 1960 and 2015: Scopus, PubMed, PsycINFO, the Web of Science, and CINAHL...
January 9, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28064478/automated-phase-mapping-with-agilefd-and-its-application-to-light-absorber-discovery-in-the-v-mn-nb-oxide-system
#17
Santosh K Suram, Yexiang Xue, Junwen Bai, Ronan Le Bras, Brendan Rappazzo, Richard Bernstein, Johan Bjorck, Lan Zhou, R Bruce van Dover, Carla P Gomes, John M Gregoire
Rapid construction of phase diagrams is a central tenet of combinatorial materials science with accelerated materials discovery efforts often hampered by challenges in interpreting combinatorial X-ray diffraction data sets, which we address by developing AgileFD, an artificial intelligence algorithm that enables rapid phase mapping from a combinatorial library of X-ray diffraction patterns. AgileFD models alloying-based peak shifting through a novel expansion of convolutional nonnegative matrix factorization, which not only improves the identification of constituent phases but also maps their concentration and lattice parameter as a function of composition...
January 9, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28057608/acupuncture-for-children-with-cerebral-palsy-a-systematic-review-protocol
#18
Taipin Guo, Bowen Zhu, Qian Zhang, Yejiao Yang, Qi He, Xinghe Zhang, Xiantao Tai
BACKGROUND: Cerebral palsy (CP), a childhood disease of high morbidity and serious harmfulness, has no effective therapies to completely relieve the associated pain. Acupuncture has been used widely in China to alleviate several CP symptoms, such as pain and motion disorders, despite the deficiency of high-quality evidence related to this practice. OBJECTIVE: The aim of this systematic review protocol is to assess the efficacy and safety of acupuncture for the treatment of children with CP...
January 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28057607/the-value-of-electronic-medical-record-implementation-in-mental-health-care-a-case-study
#19
Sanaz Riahi, Ilan Fischler, Melanie I Stuckey, Philip E Klassen, John Chen
BACKGROUND: Electronic medical records (EMR) have been implemented in many organizations to improve the quality of care. Evidence supporting the value added to a recovery-oriented mental health facility is lacking. OBJECTIVE: The goal of this project was to implement and customize a fully integrated EMR system in a specialized, recovery-oriented mental health care facility. This evaluation examined the outcomes of quality improvement initiatives driven by the EMR to determine the value that the EMR brought to the organization...
January 5, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28057312/design-and-evaluation-of-reform-plan-for-local-academic-nursing-challenges-using-action-research
#20
Marziyeh Asadizaker, Zhila Abedsaeedi, Heidarali Abedi, Azadeh Saki
PURPOSE: This study identifies challenges to the first nurse training program for undergraduate nursing students at a nursing and midwifery school in Iran using a collaborative approach in order to improve the program. METHODS: Action research was used as a research strategy with qualitative content analysis and quantitative evaluation. The participants were 148 individuals from nursing academic and clinical settings, including administrators, faculty members, students, and staff nurses...
December 2016: Asian Nursing Research
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