Reda F A Abdelhameed, Asmaa I Ali, Sameh S Elhady, Hend E Abo Mansour, Eman T Mehanna, Sarah M Mosaad, Salma A Ibrahim, Rawan H Hareeri, Jihan M Badr, Nermeen A Eltahawy
Despite the efficient anti-cancer capabilities of methotrexate (MTX), it may induce myelosuppression, liver dysfunction and testicular toxicity. The purpose of this investigation was to determine whether Marrubium alysson L. ( M. alysson L.) methanolic extract and its polyphenol fraction could protect mouse testicles from MTX-induced damage. We also investigated the protective effects of three selected pure flavonoid components of M. alysson L. extract. Mice were divided into seven groups (n = 8): (1) normal control, (2) MTX, (3) Methanolic extract + MTX, (4) Polyphenolic fraction + MTX, (5) Kaempferol + MTX, (6) Quercetin + MTX, and (7) Rutin + MTX...
September 3, 2022: Plants (Basel, Switzerland)