keyword
MENU ▼
Read by QxMD icon Read
search

Ldh AND Diabetes

keyword
https://www.readbyqxmd.com/read/28202270/acute-metabolic-and-endocrine-responses-induced-by-glucose-and-fructose-in-healthy-young-subjects-a-double-blinded-randomized-crossover-trial
#1
Wenwen Cai, Jie Li, Jiahui Shi, Bo Yang, Jun Tang, Helen Truby, Duo Li
BACKGROUND AND OBJECTIVE: A rise in fructose consumption has been implicated in the etiology of obesity, diabetes and cardiovascular disease. Serum uric acid (UA) elevates after fructose ingestion, increasing the risk of cardiovascular disease. However, the impact of fructose ingestion on nitric oxide (NO) has not yet been confirmed. The aim of this study was to investigate the postprandial metabolic and endocrine responses following an acute ingestion of fructose and glucose in healthy subjects...
February 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28089584/pterostilbene-attenuates-high-glucose-induced-oxidative-injury-in-hippocampal-neuronal-cells-by-activating-nuclear-factor-erythroid-2-related-factor-2
#2
Yang Yang, Chongxi Fan, Bodong Wang, Zhiqiang Ma, Dongjin Wang, Bing Gong, Shouyin Di, Shuai Jiang, Yue Li, Tian Li, Zhi Yang, Erping Luo
In the present study, neuroblastoma (SH-SY5Y) cells were used to investigate the mechanisms mediating the potential protective effects of pterostilbene (PTE) against mitochondrial metabolic impairment and oxidative stress induced by hyperglycemia for mimicking the diabetic encephalopathy. High glucose medium (100mM) decreased cellular viability after 24h incubation which was evidenced by: (i) reduced mitochondrial complex I and III activities; (ii) reduced mitochondrial cytochrome C; (iii) increased reactive oxygen species (ROS) generation; (iv) decreased mitochondrial membrane potential (ΔΨm); and (v) increased lactate dehydrogenase (LDH) levels...
January 9, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28078246/the-effects-of-crocin-insulin-and-their-co-administration-on-the-heart-function-and-pathology-in-streptozotocin-induced-diabetic-rats
#3
Amir Abbas Farshid, Esmaeal Tamaddonfard, Masoumeh Moradi-Arzeloo, Navideh Mirzakhani
OBJECTIVE: Crocin is a saffron constituent with a potent anti-oxidant activity. The present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. MATERIALS AND METHODS: Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ, 50 mg/kg). Thereafter, crocin (5, 10 and 20 mg/kg, i.p.), subcutaneous (s.c.) injection of insulin (4 IU/kg) and their combination were administered for eight weeks...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28027533/quercetin-ameliorates-oxidative-stress-inflammation-and-apoptosis-in-the-heart-of-streptozotocin-nicotinamide-induced-adult-male-diabetic-rats
#4
Josef Roslan, Nelli Giribabu, Kamarulzaman Karim, Naguib Salleh
INTRODUCTION: Quercetin is known to possess beneficial effects in ameliorating diabetic complications, however the mechanisms underlying cardioprotective effect of this compound in diabetes is not fully revealed. In this study, quercetin effect on oxidative stress, inflammation and apoptosis in the heart in diabetes were investigated. Normal and streptozotocin-nicotinamide induced adult male diabetic rats received quercetin (10, 25 and 50mg/kg/bw) orally for 28days were anesthetized and hemodynamic parameters i...
February 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27989876/iridoid-glycoside-from-cornus-officinalis-ameliorated-diabetes-mellitus-induced-testicular-damage-in-male-rats-involvement-of-suppression-of-the-ages-rage-p38-mapk-signaling-pathway
#5
Yuping Chen, Yunhao Wu, Xiaoyang Gan, Kai Liu, L V Xing, Hongsheng Shen, Guoying Dai, Huiqin Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis (CO) has been widely used as a traditional Chinese medicine for treating diabetes mellitus (DM) and its complications. Iridoid glycoside from C. officinalis (IGCO) can resist apoptosis, hyperglycemia, oxidation and so on. The aim of this study was to investigate the therapeutic effects of IGCO on DM-induced testicular damage through inhibition of the AGEs/RAGE/p38 MAPK signaling pathway. MATERIALS AND METHODS: A DM model of male Wistar rats was induced with streptozotocin injection (30mg/kg, i...
October 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27893660/salivary-lactate-dehydrogenase-and-aminotransferases-in-diabetic-patients
#6
Barbara Malicka, Katarzyna Skoskiewicz-Malinowska, Urszula Kaczmarek
Diabetes mellitus (DM) is a group of metabolic diseases resulting from impaired insulin secretion and/or action. DM is characterized by hyperglycemia that can lead to the dysfunction or damage of organs, including the salivary glands.The aim of this study was to compare the levels of salivary lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic patients.The study was approved by the Bioethics Committee of Wroclaw Medical University (Poland). The study comprised 90 adults of both sexes, aged 21 to 57 years...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27889750/metformin-protects-neurons-against-oxygen-glucose-deprivation-reoxygenation-induced-injury-by-down-regulating-mad2b
#7
Xianfang Meng, Guangpin Chu, Zhihua Yang, Ping Qiu, Yue Hu, Xiaohe Chen, Wenpeng Peng, Chen Ye, Fang-Fang He, Chun Zhang
BACKGROUND/AIMS: Metformin, the common medication for type II diabetes, has protective effects on cerebral ischemia. However, the molecular mechanisms are far from clear. Mitotic arrest deficient 2-like protein 2 (MAD2B), an inhibitor of the anaphase-promoting complex (APC), is widely expressed in hippocampal and cortical neurons and plays an important role in mediating high glucose-induced neurotoxicity. The present study investigated whether metformin modifies the expression of MAD2B and to exert its neuroprotective effects in primary cultured cortical neurons during oxygen-glucose deprivation/reoxygenation (OGD/R), a widely used in vitro model of ischemia/reperfusion...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27876485/cannabinoid-receptors-and-trpa1-on-neuroprotection-in-a-model-of-retinal-ischemia
#8
D S M Araújo, V S Miya-Coreixas, P Pandolfo, K C Calaza
Retinal ischemia is a pathological event present in several retinopathies such as diabetic retinopathy and glaucoma, leading to partial or full blindness with no effective treatment available. Since synthetic and endogenous cannabinoids have been studied as modulators of ischemic events in the central nervous system (CNS), the present study aimed to investigate the involvement of cannabinoid system in the cell death induced by ischemia in an avascular (chick) retina. We observed that chick retinal treatment with a combination of WIN 55212-2 and cannabinoid receptor antagonists (either AM251/O-2050 or AM630) decreased the release of lactate dehydrogenase (LDH) induced by retinal ischemia in an oxygen and glucose deprivation (OGD) model...
November 19, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27829984/activation-of-aldh2-with-low-concentration-of-ethanol-attenuates-myocardial-ischemia-reperfusion-injury-in-diabetes-rat-model
#9
Pin-Fang Kang, Wen-Juan Wu, Yang Tang, Ling Xuan, Su-Dong Guan, Bi Tang, Heng Zhang, Qin Gao, Hong-Ju Wang
The aim of this paper is to observe the change of mitochondrial aldehyde dehydrogenase 2 (ALDH2) when diabetes mellitus (DM) rat heart was subjected to ischemia/reperfusion (I/R) intervention and analyze its underlying mechanisms. DM rat hearts were subjected to 30 min regional ischemia and 120 min reperfusion in vitro and pretreated with ALDH2 activator ethanol (EtOH); cardiomyocyte in high glucose (HG) condition was pretreated with ALDH2 activator Alda-1. In control I/R group, myocardial tissue structure collapse appeared...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27829418/hepatoprotective-potential-of-fagonia-olivieri-dc-against-acetaminophen-induced-toxicity-in-rat
#10
Umbreen Rashid, Muhammad Rashid Khan, Moniba Sajid
BACKGROUND: Fagonia olivieri (DC) being used for the treatment of diabetes, cancer, fever and claimed to be effective in many other stress related disorders. In this study we have evaluated the F. olivieri whole methanol extract and its derived fractions for various in vitro and in vivo antioxidant studies. METHODS: The crude methanol extract of the whole plant of F. olivieri (FOM) and its derived fractions; n-hexane (FOH), chloroform (FOC), ethyl acetate (FOE), n-butanol (FOB) and aqueous (FOA) were evaluated for the total phenolic and flavonoid content and in vitro antioxidant abilities...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27802903/dendrobium-officinale-kimura-et-migo-attenuates-diabetic-cardiomyopathy-through-inhibiting-oxidative-stress-inflammation-and-fibrosis-in-streptozotocin-induced-mice
#11
Zhihao Zhang, Duoduo Zhang, Mengmeng Dou, Zhubo Li, Jie Zhang, Xiaoyan Zhao
Dendrobium officinale Kimura et Migo (Dendrobium catenatum Lindley), a prized traditional Chinese Medicine, has been used in China and Southeast Asian countries for centuries. The present study was aimed to investigate the effects and the possible mechanisms of the Dendrobium officinale extracts (DOE) on diabetic cardiomyopathy in mice. The diabetic model was induced by intraperitoneal injection of streptozotocin at the dose of 50mg/kg body weight for 5 consecutive days. After 8 weeks treatment of DOE, mice were sacrificed, blood sample and heart tissues were collected...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27738514/association-between-liver-enzymes-and-incident-type-2-diabetes-in-singapore-chinese-men-and-women
#12
Ye-Li Wang, Woon-Puay Koh, Jian-Min Yuan, An Pan
AIMS: To assess the association between liver enzymes and the risk of type 2 diabetes (T2D) in a Chinese population. METHODS: A nested case-control study comprising 571 T2D cases and 571 matched controls was conducted within the Singapore Chinese Health Study. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were quantified in baseline plasma collected from them, while γ-glutamyltransferase (GGT) was assayed among 255 T2D cases with baseline hemoglobin A1c <6...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27709232/a-study-on-neuroprotective-effects-of-curcumin-on-the-diabetic-rat-brain
#13
L Zhang, X-J Kong, Z-Q Wang, F-S Xu, Y-T Zhu
The present study was aimed to study the neuroprotective therapeutic effect of curcumin on the male albino rat brain. Subarachnoid hemorrhage leads to severe mortality rate and morbidity, and oxidative stress is a crucial factor in subarachnoid hemorrhage. Therefore, we investigated the effect of curcumin on oxidative stress and glutamate and glutamate transporter-1 on a subarachnoid hemorrhage-induced male albino rats. The curcumin commonly used for the treatment and saline used for the control. Curcumin (10 mg/kg bwt) dissolved in saline and administered orally to the rats for one week...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27684054/high-glucose-concentration-abrogates-sevoflurane-postconditioning-cardioprotection-by-advancing-mitochondrial-fission-but-dynamin-related-protein-1-inhibitor-restores-these-effects
#14
Jin Yu, Yiliyaer Maimaitili, Peng Xie, Jianjiang Wu, Jiang Wang, Yining Yang, Haiping Ma, Hong Zheng
AIM: Hyperglycaemia-induced cell injury is a primary cause of cardiovascular complications in diabetic patients. In vivo studies demonstrated that sevoflurane postconditioning (SpostC) was cardioprotective against ischaemia/reperfusion injury, which was blocked by hyperglycaemia. This study investigated whether high glucose concentration abrogated SpostC cardioprotection in vitro by advancing mitochondrial fission and whether mitochondrial division inhibitor-1 (Mdivi-1) restored SpostC cardioprotection in cultured primary neonatal rat cardiomyocytes (NCMs)...
September 29, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27624102/saturated-fatty-acids-activate-caspase-4-5-in-human-monocytes-triggering-il-1%C3%AE-and-il-18-release
#15
Nicolas J Pillon, Kenny L Chan, Shitian Zhang, Marios Mejdani, Maya R Jacobson, Alexandre Ducos, Philip J Bilan, Wenyan Niu, Amira Klip
Obesity is associated with metabolic tissue infiltration by monocyte-derived macrophages. Saturated fatty acids contribute to proinflammatory gene induction in tissue-embedded immune cells. However, it is unknown how circulating monocytes, the macrophage precursors, react to high-fat environments. In macrophages, saturated fatty acids activate inflammatory pathways and, notably, prime caspase-associated inflammasomes. Inflammasome-activated IL-1β contributes to type 2 diabetes. We hypothesized that 1) human monocytes from obese patients show caspase activation, and 2) fatty acids trigger this response and consequent release of IL-1β/IL-18...
November 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27565845/therapeutic-effect-of-apple-pectin-in-obese-rats
#16
Noura Samout, Hafsia Bouzenna, Sabah Dhibi, Sana Ncib, Abdelfattah ElFeki, Najla Hfaiedh
Obesity is the most common nutritional disorder and is associated with significant comorbidities such as dyslipidemia, atherosclerosis and type 2 diabetes. This pathology is changing worldwide and is a risk factor for cardiovascular disease. This study, carried out on adult male Wistar rats, evaluates the inhibitory effects of supplementation with apple pectin molecule on obesity. Under our experimental conditions, administration of pectin molecule decreased 1) the total cholesterol (TC), LDL-cholesterol (LDL-ch) and triglycerides (TG) levels as well as ASAT, ALAT, LDH, ALP, UREA and uric acid (UC) levels in blood serum; and 2) increased the creatinine levels (CREA), compared to HFD group...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27512375/doxorubicin-induces-inflammatory-modulation-and-metabolic-dysregulation-in-diabetic-skeletal-muscle
#17
Rashmi Supriya, Bjorn T Tam, Xiao M Pei, Christopher W Lai, Lawrence W Chan, Benjamin Y Yung, Parco M Siu
Anti-cancer agent doxorubicin (DOX) has been demonstrated to worsen insulin signaling, engender muscle atrophy, trigger pro-inflammation, and induce a shift to anaerobic glycolytic metabolism in skeletal muscle. The myotoxicity of DOX in diabetic skeletal muscle remains largely unclear. This study examined the effects of DOX on insulin signaling, muscle atrophy, pro-/anti-inflammatory microenvironment, and glycolysis metabolic regulation in skeletal muscle of db/db diabetic and db/+ non-diabetic mice. Non-diabetic db/+ mice and diabetic db/db mice were randomly assigned to the following groups: db/+CON, db/+DOX, db/dbCON, and db/dbDOX...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27490779/swertiamarin-ameliorates-oleic-acid-induced-lipid-accumulation-and-oxidative-stress-by-attenuating-gluconeogenesis-and-lipogenesis-in-hepatic-steatosis
#18
Tushar P Patel, Komal Rawal, Sanket Soni, Sarita Gupta
Swertiamarin, a bitter secoiridoid glycoside, is an antidiabetic drug with lipid lowering activity meliorates insulin resistance in Type 2 Diabetes condition. Therefore, the study was designed to explore the antioxidant and hypolipidemic activity of swertiamarin in ameliorating NAFLD caused due to hepatic lipid accumulation, inflammation and insulin resistance. Steatosis was induced in HepG2 cells by supplementing 1mM oleic acid (OA) for 24h which was marked by significant accumulation of lipid droplets. This was determined by Oil Red O (ORO) staining and triglyceride accumulation...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27430285/overexpression-of-dj-1-reduces-oxidative-stress-and-attenuates-hypoxia-reoxygenation-injury-in-nrk-52e-cells-exposed-to-high-glucose
#19
Zi-Ying Shen, Qian Sun, Zhong-Yuan Xia, Qing-Tao Meng, Shao-Qing Lei, Bo Zhao, Ling-Hua Tang, Rui Xue, Rong Chen
Patients with diabetes are more vulnerable to renal ischemia/reperfusion (I/R) injury, which is implicated in hyperglycemia-induced oxidative stress. We previously reported that the hyperglycemia-induced inhibition of DJ-1, a novel oncogene that exhibits potent antioxidant activity, is implicated in the severity of myocardial I/R injury. In the present study, we aimed to explore the role of DJ-1 in hypoxia/reoxygenation (H/R) injury in renal cells exposed to high glucose (HG). For this purpose, NRK-52E cells were exposed to HG (30 mM) for 48 h and then exposed to hypoxia for 4 h and reoxygenation for 2 h, which significantly decreased cell viability and superoxide dismutase (SOD) activity, and increased the malondialdehyde (MDA) content, accompanied by a decrease in DJ‑1 protein expression...
September 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27403417/metformin-alleviated-a%C3%AE-induced-apoptosis-via-the-suppression-of-jnk-mapk-signaling-pathway-in-cultured-hippocampal-neurons
#20
Bin Chen, Ying Teng, Xingguang Zhang, Xiaofeng Lv, Yanling Yin
Both diabetes and hyperinsulinemia are confirmed risk factors for Alzheimer's disease. Some researchers proposed that antidiabetic drugs may be used as disease-modifying therapies, such as metformin and thiazolidinediones, although more evidence was poorly supported. The aim of the current study is to investigate the role of metformin in Aβ-induced cytotoxicity and explore the underlying mechanisms. First, the experimental results show that metformin salvaged the neurons exposed to Aβ in a concentration-dependent manner with MTT and LDH assay...
2016: BioMed Research International
keyword
keyword
110548
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"