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https://www.readbyqxmd.com/read/28607793/the-case-of-reactive-arthritis-secondary-to-echinococcus-infestation
#1
Bülent Alım, Sinan Çetinel, M Alperen Servi, Fahrettin Bostancı, Mehmet Ozan Bingöl
Reactive arthritis is an inflammatory joint disease that develops after an infection and it usually occurs following a gastrointestinal or genitourinary system infection and it belongs to the family of arthritis called "spondyloarthritis." We wanted to represent a rare case of reactive arthritis secondary to Echinococcus infestation. Cyst hydatid disease is common in endemic regions like Turkey. Internal organ involvements, especially liver and lung, are most frequent involvements. Primary bone involvement is rare complication of Echinococcus infestation...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28596841/targeting-endosomal-acidification-by-chloroquine-analogs-as-a-promising-strategy-for-the-treatment-of-emerging-viral-diseases
#2
REVIEW
Md Abdul Alim Al-Bari
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated...
February 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28514737/integration-of-phytochemicals-and-phytotherapy-into-cancer-precision-medicine
#3
REVIEW
Thomas Efferth, Mohamed E M Saeed, Elhaj Mirghani, Awadh Alim, Zahir Yassin, Elfatih Saeed, Hassan E Khalid, Salah Daak
Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28499170/4-phenyl-quinoline-derivatives-as-potential-serotonin-receptor-ligands-with-antiproliferative-activity
#4
Pranaya V Joshi, Alim A Sayed, Ameeta RaviKumar, Vedavati G Puranik, Smita S Zinjarde
Antagonists of signaling receptors are often effective non-toxic therapeutic agents. Over the years, there have been evidences describing the role of serotonin or 5-hydroxytryptamine (5-HT) in development of cancer. Although there are reports on the antiproliferative effects of some serotonin receptor antagonists, there are very few investigations related to understanding their structure-activity relationships. In this study, we report the screening of a library of 4-phenyl quinoline derivatives for their antiproliferative activities...
May 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28471767/pharmacological-stimulation-of-neuronal-plasticity-in-acquired-brain-injury
#5
Paul Carrillo-Mora, Juan Manuel Alcantar-Shramm, Kievka M Almaguer-Benavides, Julio José Macías-Gallardo, Alim Fuentes-Bello, Marlene A Rodríguez-Barragán
INTRODUCTION: Brain injuries are one of the leading causes of disability worldwide. It is estimated that nearly half of patients who develop severe sequelae will continue with a chronic severe disability despite having received an appropriate rehabilitation program. For more than 3 decades, there has been a worldwide effort to investigate the possibility of pharmacologically stimulating the neuroplasticity process for enhancing the recovery of these patients. OBJECTIVE: The objective of this article is to make a critical and updated review of the available evidence that supports the positive effect of different drugs on the recovery from brain injury...
May 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28465441/mechanism-of-signal-propagation-in-physarum-polycephalum
#6
Karen Alim, Natalie Andrew, Anne Pringle, Michael P Brenner
Complex behaviors are typically associated with animals, but the capacity to integrate information and function as a coordinated individual is also a ubiquitous but poorly understood feature of organisms such as slime molds and fungi. Plasmodial slime molds grow as networks and use flexible, undifferentiated body plans to forage for food. How an individual communicates across its network remains a puzzle, but Physarum polycephalum has emerged as a novel model used to explore emergent dynamics. Within P. polycephalum, cytoplasm is shuttled in a peristaltic wave driven by cross-sectional contractions of tubes...
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438846/author-response-long-term-improvement-in-obsessions-and-compulsions-with-subthalamic-stimulation
#7
Paul Krack, Mircea Polosan, Stephan Chabardès, Thierry Bougerol, Claire Ardouin, Pierre Pollak, Alim Louis Benabid
No abstract text is available yet for this article.
April 25, 2017: Neurology
https://www.readbyqxmd.com/read/28367045/neutrophil-to-lymphocyte-ratio-in-patients-with-nonarteritic-anterior-ischemic-optic-neuropathy
#8
Alime Gunes, Musa Yigit, Levent Tok, Ozlem Tok
PURPOSE: To evaluate the neutrophil to lymphocyte ratio (NLR) in patients with nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: We investigated 112 subjects comprising 56 patients with NAION and 56 healthy controls at Süleyman Demirel University. Complete blood count, demographic, and clinic data from NAION patients were evaluated in this study. The NLR was calculated in all individuals and compared between the patient and control groups. Cut-off values were also determined...
April 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28347664/venestatin-a-ca-binding-protein-from-the-parasitic-nematode-strongyloides-venezuelensis-is-involved-in-the-larval-migration-process
#9
Daigo Tsubokawa, Takeshi Hatta, Taisei Kikuchi, Hiroki Maeda, Fusako Mikami, M Abdul Alim, Haruhiko Maruyama, Naotoshi Tsuji
The secretory EF-hand Ca(++)-binding proteins act as calcium signaling molecules for control of cell functions, but those proteins from parasitic helminths are poorly understood. Here, we have identified and characterized an EF-hand Ca(++)-binding protein from the rodent nematode, Strongyloides venezuelensis, termed 'venestatin', which is highly conserved in Strongyloides spp. Canonical two EF-hand domains and a signal peptide are present in venestatin. A gel mobility shift assay and Ruthenium red staining indicated that the recombinant venestatin possesses binding ability with Ca(++) ions...
July 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28345581/potential-of-biosynthesized-silver-nanoparticles-using-stenotrophomonas-sp-bhu-s7-mtcc-5978-for-management-of-soil-borne-and-foliar-phytopathogens
#10
Sandhya Mishra, Braj Raj Singh, Alim H Naqvi, H B Singh
Stenotrophomonas sp. is emerging as a popular microbe of global concern with various potential ecological roles. Biosynthesis of gold and silver nanoparticles (AgNPs) using this bacterial strain has shown promising applications in life sciences. However, there is no report on efficient agricultural applications of biosynthesized AgNPs using Stenotrophomonas sp. In this regard, successful biosynthesis of AgNPs using Stenotrophomonas sp. BHU-S7 (MTCC 5978) was monitored by Uv-visible spectrum showing surface plasmon resonance (SPR) peak at 440 nm...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28342364/therapeutic-effect-of-quercetin-in-collagen-induced-arthritis
#11
Nagaraja Haleagrahara, Socorro Miranda-Hernandez, Md Abdul Alim, Linda Hayes, Guy Bird, Natkunam Ketheesan
Quercetin, a bioactive flavonoid with anti-inflammatory, immunosuppressive, and protective properties, is a potential agent for the treatment of rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is the most commonly used animal model for studying the pathogenesis of RA. This study analysed the therapeutic role of quercetin in collagen-induced arthritis in C57BL/6 mice. The animals were allocated into five groups that were subjected to the following treatments: negative (untreated) control, positive control (arthritis-induced), arthritis+methotrexate, arthritis+quercetin, and arthritis+methotrexate+quercetin...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28340864/multi-dimensional-scores-to-predict-mortality-in-patients-with-idiopathic-pulmonary-fibrosis-undergoing-lung-transplantation-assessment
#12
Jolene H Fisher, Faris Al-Hejaili, Sonja Kandel, Alim Hirji, Shane Shapera, Marco Mura
BACKGROUND: The heterogeneous progression of idiopathic pulmonary fibrosis (IPF) makes prognostication difficult and contributes to high mortality on the waitlist for lung transplantation (LTx). Multi-dimensional scores (Composite Physiologic index [CPI], [Gender-Age-Physiology [GAP]; RIsk Stratification scorE [RISE]) demonstrated enhanced predictive power towards outcome in IPF. The lung allocation score (LAS) is a multi-dimensional tool commonly used to stratify patients assessed for LTx...
April 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28337421/zygomatic-miniplates-for-skeletal-anchorage-in-orthopedic-correction-of-class-iii-malocclusion-a-controlled-clinical-trial
#13
Erdal Bozkaya, Alime Sema Yüksel, Süleyman Bozkaya
OBJECTIVE: To evaluate the effects of facemask therapy, which was anchored from the zygomatic buttresses of the maxilla by using two miniplates, in skeletal Class III patients with maxillary deficiency. METHODS: Eighteen skeletal Class III patients (10 girls and 8 boys; mean age, 11.4 ± 1.28 years) with maxillary deficiency were treated using miniplate-anchored facemasks, and their outcomes were compared with those of a Class III control group (9 girls and 9 boys; mean age, 10...
March 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28303062/perception-and-attitude-of-medical-doctors-in-dhaka-bangladesh-with-regard-to-ayurvedic-medicine
#14
Yoshitoku Yoshida, Md Abdul Alim, Zakia Alam, Mohammad Asaduzzaman, Yasuko Yoshida, Shahabuddin Manikdrs
The World Health Organization (WHO) Traditional Medicine Strategy (2014-2023) aimed to help member states promote the safe and effective use of traditional medicine. While economic conditions have markedly improved in Bangladesh, the country is experiencing significant public health problems. Because of limited medical resources, there is a strong incentive to enhance complementary and alternative medicine usage in Bangladesh. Therefore, this study aimed to confirm the perceptions and attitudes of medical doctors (MDs) in Dhaka, Bangladesh, with regard to Ayurvedic medicine (AM)...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28299414/photobiomodulation-induced-changes-in-a-monkey-model-of-parkinson-s-disease-changes-in-tyrosine-hydroxylase-cells-and-gdnf-expression-in-the-striatum
#15
Nabil El Massri, Ana P Lemgruber, Isobel J Rowe, Cécile Moro, Napoleon Torres, Florian Reinhart, Claude Chabrol, Alim-Louis Benabid, John Mitrofanis
Intracranial application of red to infrared light, known also as photobiomodulation (PBM), has been shown to improve locomotor activity and to neuroprotect midbrain dopaminergic cells in rodent and monkey models of Parkinson's disease. In this study, we explored whether PBM has any influence on the number of tyrosine hydroxylase (TH)(+)cells and the expression of GDNF (glial-derived neurotrophic factor) in the striatum. Striatal sections of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-treated mice and monkeys and 6-hydroxydopamine (6OHDA)-lesioned rats that had PBM optical fibres implanted intracranially (or not) were processed for immunohistochemistry (all species) or western blot analysis (monkeys)...
March 15, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28265722/mr-imaging-of-carotid-webs
#16
Mari E Boesen, Prasanna Venkatesan Eswaradass, Dilip Singh, Alim P Mitha, Mayank Goyal, Richard Frayne, Bijoy K Menon
PURPOSE: We propose a magnetic resonance (MR) imaging protocol for the characterization of carotid web morphology, composition, and vessel wall dynamics. The purpose of this case series was to determine the feasibility of imaging carotid webs with MR imaging. METHODS: Five patients diagnosed with carotid web on CT angiography were recruited to undergo a 30-min MR imaging session. MR angiography (MRA) images of the carotid artery bifurcation were acquired. Multi-contrast fast spin echo (FSE) images were acquired axially about the level of the carotid web...
March 6, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28265528/resident-development-via-progress-testing-and-test-marking-an-innovation-and-program-evaluation
#17
Karen Schiff, D Josh Williams, Alim Pardhan, Ian Preyra, Shelly-Anne Li, Teresa Chan
INTRODUCTION: Since 2008, the McMaster University Royal College Emergency Medicine residency training program has run practice Short Answer Question (SAQ) examinations to help residents test their knowledge and gain practice in answering exam-style questions. However, marking this type of SAQ exam is time-consuming. METHODS: To help address this problem, we require that senior residents help mark at least one exam per year alongside faculty members. Examinees' identities are kept anonymous by assigning a random number to each resident, which is only decoded after marking...
January 23, 2017: Curēus
https://www.readbyqxmd.com/read/28255469/differential-diagnosis-of-parotid-lipoma-in-a-breast-ca-patient
#18
Melda Misirlioglu, Yagmur Yilmaz Akyil, Mehmet Zahit Adisen, Alime Okkesim
Lipomas are common benign tumors usually detected on the torso, neck, upper thighs, and upper arms. However, they are rarely found in the parotid gland region. Because of their rarity at this site, they are not often considered in the differential diagnosis of parotid tumors. This report describes a rare case of a lipoma in the superficial lobe of parotid gland. A 71-year-old female patient admitted to our department complaining about swelling and pain in the posterior area of the left mandibular region since one month...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28251195/chemical-characterization-of-a-novel-polysaccharide-askp-1-from-artemisia-sphaerocephala-krasch-seed-and-its-macrophage-activation-via-mapk-pi3k-akt-and-nf-%C3%AE%C2%BAb-signaling-pathways-in-raw264-7-cells
#19
Daoyuan Ren, Dehui Lin, Aamina Alim, Quan Zheng, Xingbin Yang
The aim of this study was to investigate the molecular mechanism underlying the immunomodulatory effect of the purified Artemisia sphaerocephala Krasch seed polysaccharide (ASKP-1) in RAW264.7 macrophages. Chemical characteristic analysis revealed that ASKP-1 consisted of 14.1% mannose, 56.9% glucose and 19.6% galactose with the average molecular weight of 9.08 × 10(5) Da and the mixed glycan backbone structure containing 1→4)-Glcp (39.8%), 1→6)-Galp (18.8%), 1→3,6)-Manp (19.6%), 1→)-Glcp (10.8%), 2→6)-Manp (4...
March 2, 2017: Food & Function
https://www.readbyqxmd.com/read/28231181/the-determinants-of-organic-vegetable-purchasing-in-jabodetabek-region-indonesia
#20
Alim Setiawan Slamet, Akira Nakayasu, Hu Bai
Over the last few years, the global market of organic vegetables has grown. This is due to increased consumer concern regarding environmental and health issues, especially for food products. This study aims to examine factors that influence consumer behavior in purchasing organic vegetables. In this study, data were obtained from household surveys conducted in the Jabodetabek region (Greater Jakarta) from February to March 2015. Descriptive analysis, factor analysis, and a binary logit model were used to analyze the data...
December 7, 2016: Foods (Basel, Switzerland)
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