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M Mamun Huda, Vijay Kumar, Murari Lal Das, Debashis Ghosh, Jyoti Priyanka, Pradeep Das, Abdul Alim, Greg Matlashewski, Axel Kroeger, Eduardo Alfonso-Sierra, Dinesh Mondal
BACKGROUND: New methods for controlling sand fly are highly desired by the Visceral Leishmaniasis (VL) elimination program of Bangladesh, India and Nepal for its consolidation and maintenance phases. To support the program we investigated safety, efficacy and cost of Durable Wall Lining to control sand fly. METHODS: This multicentre randomized controlled study in Bangladesh, India and Nepal included randomized two intervention clusters and one control cluster. Each cluster had 50 households except full wall surface coverage (DWL-FWSC) cluster in Nepal which had 46 households...
October 6, 2016: BMC Infectious Diseases
Tugba Karaman, Serkan Dogru, Serkan Karaman, Selim Demir, Ziya Kaya, Mustafa Suren, Semih Arici, Mursel Kahveci, Sait Alim
STUDY OBJECTIVE: To determine the effects of the McGrath Series 5 video laryngoscope on intraocular pressure (IOP) during laryngoscopy. DESIGN: Prospective, randomized, double blind. SETTING: Operating room. PATIENTS: Eighty adult patients of American Society of Anesthesiologist physical status 1 scheduled for nonophthalmic elective surgery under general anesthesia. INTERVENTIONS: The endotracheal intubation was provided using McGrath series 5 video laryngoscope in MG group (n=40) or Macintosh laryngoscope in M group (n=40)...
November 2016: Journal of Clinical Anesthesia
Christian A Klöckner, Alim Nayum
Energy efficiency upgrades of privately owned homes like adding to the insulation layers in the walls, roof or floor, or replacing windows with more efficiently insulated versions can contribute significantly to reducing the energy impact of the building sector and thus also the CO2 footprint of a household. However, even in countries like Norway that have a rather high rate of renovation, energy upgrades are not always integrated into such a refurbishment project. This study tests which structural and internal psychological barriers hinder and which drivers foster decision-making to implement such measures, once a renovation project is planned...
2016: Frontiers in Psychology
Hueiming Liu, Richard Lindley, Mohammed Alim, Cynthia Felix, Dorcas B C Gandhi, Shweta J Verma, Deepak Kumar Tugnawat, Anuradha Syrigapu, Ramaprabhu Krishnappa Ramamurthy, Jeyaraj D Pandian, Marion Walker, Anne Forster, Craig S Anderson, Peter Langhorne, Gudlavalleti Venkata Satyanarayana Murthy, Bindiganavale Ramaswamy Shamanna, Maree L Hackett, Pallab K Maulik, Lisa A Harvey, Stephen Jan
INTRODUCTION: We are undertaking a randomised controlled trial (fAmily led rehabiliTaTion aftEr stroke in INDia, ATTEND) evaluating training a family carer to enable maximal rehabilitation of patients with stroke-related disability; as a potentially affordable, culturally acceptable and effective intervention for use in India. A process evaluation is needed to understand how and why this complex intervention may be effective, and to capture important barriers and facilitators to its implementation...
September 15, 2016: BMJ Open
Melissa Kane, Trinity M Zang, Suzannah J Rihn, Fengwen Zhang, Tonya Kueck, Mudathir Alim, John Schoggins, Charles M Rice, Sam J Wilson, Paul D Bieniasz
Interferons (IFNs) exert their anti-viral effects by inducing the expression of hundreds of IFN-stimulated genes (ISGs). The activity of known ISGs is insufficient to account for the antiretroviral effects of IFN, suggesting that ISGs with antiretroviral activity are yet to be described. We constructed an arrayed library of ISGs from rhesus macaques and tested the ability of hundreds of individual macaque and human ISGs to inhibit early and late replication steps for 11 members of the retroviridae from various host species...
September 14, 2016: Cell Host & Microbe
Alime Gunes, Funda Yıldırım Bas, Bahriye Arslan, Levent Tok, Özlem Tok, Zeliha Salman
PURPOSE: To assess corneal parameters in constitutional thinness (CT) subjects and to compare them with those of healthy individuals. METHODS: Twenty-four CT subjects (BMI < 18.5 kg/m(2)) and 24 healthy subjects (BMI: 18.5-25 kg/m2) were enrolled in this observational cross-sectional study. All participants were screened for age, gender, and medical history, then underwent a detailed ophthalmological examination. Corneal parameters were evaluated by Scheimpflug imaging...
September 6, 2016: Seminars in Ophthalmology
Karen Alim, Shahaf Armon, Boris I Shraiman, Arezki Boudaoud
Growth pattern dynamics lie at the heart of morphogenesis. Here, we investigate the growth of plant leaves. We compute the conformal transformation that maps the contour of a leaf at a given stage onto the contour of the same leaf at a later stage. Based on the mapping we predict the local displacement field in the leaf blade and find it to agree with the experimentally measured displacement field to 92%. This approach is applicable to any two-dimensional system with locally isotropic growth, enabling the deduction of the whole growth field just from observation of the tissue contour...
2016: Physical Biology
Altan Alim, Yalcin Erdogan, Yildiray Yuzer, Yaman Tokat, Arzu Oezcelik
BACKGROUND: The graft-to-recipient-weight-ratio (GRWR) is an important selection criteria for living donor liver transplantation (LDLT). The generally accepted threshold is known to be 0.8. We believe that this threshold can be reduced under certain conditions. The aim of this study was to evaluate the results of these patients with GRWR <0.8. PATIENTS AND METHODS: Between 2004 and 2015, 649 patients underwent right lobe LDLT for end-stage liver disease in adult patients...
August 10, 2016: Liver Transplantation
Meagan Walker, Ameet Singh, Alim Nazarali, Thomas W G Gibson, Joyce Rousseau, J Scott Weese
OBJECTIVE: To compare the minimum inhibitory concentration (MIC) of four antimicrobials in planktonic vs. biofilm-associated Staphylococcus pseudintermedius. STUDY DESIGN: In vitro study. SAMPLE POPULATION: 78 isolates from dogs colonized or infected with methicillin-resistant S. pseudintermedius (MRSP, n=39) or methicillin-susceptible S. pseudintermedius (MSSP, n=39). METHODS: Agar dilution was used to determine the MIC of amikacin, cefazolin, enrofloxacin, and gentamicin for planktonic bacteria...
October 2016: Veterinary Surgery: VS
Ali Alim-Marvasti, Jason Ho, Mark Weatherall, Maneesh Patel, Sheena George, Stuart Viegas
A 40-year-old woman presented with a side-locked headache with autonomic features, which then switched sides before reverting to the original side. The atypical features of side swapping, partial response to indometacin and abnormal optic disc appearances ultimately led to a diagnosis of recurrent posterior scleritis. We discuss the differential diagnosis of trigeminal autonomic cephalgias and its secondary causes, and provide practical pointers for its investigation and management.
August 5, 2016: Practical Neurology
Janusz Nowotny, Tadeusz Bak, Elisabeth C Dickey, Wolfgang Sigmund, Mohammad A Alim
This work considers the equilibration kinetics of Nb-doped TiO2 single crystal (0.066 atom % Nb) during oxidation and reduction within a wide range of temperature (1073-1298 K) and oxygen activity (10(-14)-10(5) Pa). The associated semiconducting properties were determined using simultaneous measurements of both electrical conductivity and thermoelectric power. It is shown that the chemical diffusion coefficient in the strongly reducing regime, p(O2) < 10(-5) Pa, is 4 orders of magnitude larger than that in the reducing and oxidizing regimes, 10 Pa < p(O2) < 22 kPa...
September 1, 2016: Journal of Physical Chemistry. A
Pallavi Bhambri, Ali Sarvi, John H Wong, Uttandaraman Sundararaj, Alim P Mitha
OBJECTIVE: The only pharmacologic prophylaxis for cerebral vasospasm after subarachnoid hemorrhage is oral nimodipine. A novel way to mitigate this risk may be to design a drug eluting stent that elutes verapamil over the time period typically associated with vasospasm. In this study, we explore different methods of coating nitinol stents with a bioabsorbable polymer and determine the release profile of various verapamil coated stents for the potential treatment of vasospasm. METHODS: Nitinol stents were coated with different concentrations of poly(lactic acid-co-glycolic acid) (PLGA) in chloroform solution and using three coating techniques: dip coating, spin coating, and electrospinning...
July 29, 2016: Journal of Neurointerventional Surgery
Stefan Thomas Lang, Zarina Assis, John H Wong, William Morrish, Alim P Mitha
A 62-year-old woman presented with a subarachnoid hemorrhage secondary to a ruptured right supraclinoid internal carotid artery blister aneurysm. She was treated in an emergent fashion with two flow diverting pipeline embolization devices (PED) deployed in a telescoping fashion. CT angiography performed for unrelated reasons at 7 months showed successful treatment of the aneurysm without evidence of residual aneurysm. However, a follow-up digital subtraction angiogram performed at 9 months showed a large aneurysm in a modified position compared with the original aneurysm...
July 28, 2016: Journal of Neurointerventional Surgery
M Ethan MacDonald, Parviz Dolati, Alim P Mitha, John H Wong, Richard Frayne
PURPOSE: To explore phase contrast (PC) magnetic resonance imaging of aneurysms and arteriovenous malformations (AVM). PC imaging obtains a vector field of the velocity and can yield additional hemodynamic information, including: volume flow rate (VFR) and intravascular pressure. We expect to find lower VFR distal to aneurysms and higher VFR in vessels of the AVM. MATERIALS AND METHODS: Five cerebral aneurysm and three AVM patients were imaged with PC techniques and compared to VFR of a healthy cohort...
November 2016: Magnetic Resonance Imaging
Cong Li, Dongxiao Sun, Shengli Zhang, Shaohua Yang, M A Alim, Qin Zhang, Yanhua Li, Lin Liu
BACKGROUND: A previous genome-wide association study deduced that one (ARS-BFGL-NGS-39328), two (Hapmap26001-BTC-038813 and Hapmap31284-BTC-039204), two (Hapmap26001-BTC-038813 and BTB-00246150), and one (Hapmap50366-BTA-46960) genome-wide significant single nucleotide polymorphisms (SNPs) associated with milk fatty acids were close to or within the fatty acid synthase (FASN), peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PPARGC1A), ATP-binding cassette, sub-family G, member 2 (ABCG2) and insulin-like growth factor 1 (IGF1) genes...
2016: BMC Genetics
Alime Gunes, Musa Yigit, Levent Tok, Ozlem Tok
PURPOSE: To evaluate anterior segment parameters in patients with pseudoexfoliation syndrome (PXS) using Scheimpflug imaging. METHODS: Forty-three PXS patients and 43 healthy control subjects were included in this cross-sectional study. All participants underwent a detailed ophthalmologic examination. Anterior segment parameters were measured using a Scheimpflug system. RESULTS: Considering the PXS and control groups, the mean corneal thicknesses at the apex point (536 ± 31 and 560 ± 31 µm, respectively, p=0...
May 2016: Arquivos Brasileiros de Oftalmologia
Samet Mert, Zuhal Alım, Mehmet Mustafa İşgör, Şükrü Beydemir, Rahmi Kasımoğulları
A series of 1-(3-substituted-phenyl)-5-phenyl-N(3),N(4)-bis(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-3,4-dicarboxamides (4-15) were synthesized. The structures of these pyrazole-sulfonamides were confirmed by FT-IR, (1)H NMR, (13)C NMR and elemental analysis methods. Human cytosolic carbonic anhydrase (CA, EC isozymes (hCA I and II) were purified from erythrocyte cells by affinity chromatography. The inhibitory effects of newly synthesized derivatives (4-15) were investigated in vitro on esterase activities of these isozymes...
October 2016: Bioorganic Chemistry
Stefan Thomas Lang, Zarina Assis, John H Wong, William Morrish, Alim P Mitha
A 62-year-old woman presented with a subarachnoid hemorrhage secondary to a ruptured right supraclinoid internal carotid artery blister aneurysm. She was treated in an emergent fashion with two flow diverting pipeline embolization devices (PED) deployed in a telescoping fashion. CT angiography performed for unrelated reasons at 7 months showed successful treatment of the aneurysm without evidence of residual aneurysm. However, a follow-up digital subtraction angiogram performed at 9 months showed a large aneurysm in a modified position compared with the original aneurysm...
2016: BMJ Case Reports
Altan Alim, Yaman Tokat, Yalcin Erdogan, Zafer Gokkaya, Murat Dayangac, Yildiray Yuzer, Arzu Oezcelik
FH is an autosomal dominant genetic disorder characterized by increased TC and LDL level, which leads to xanthomas, atherosclerosis, and cardiac complications even in childhood. The treatment options are diet, medical treatment, lipid apheresis, and LT. The aim of our study was to analyze our data of patients with FH. Between 2004 and 2015, there were 51 patients who underwent pediatric LT at our center. All patients with FH were identified, and the data were retrospectively analyzed. There were eight patients with homozygous FH in the median age of 10 years (IQR 6-12) who underwent LT...
July 20, 2016: Pediatric Transplantation
Jodie L Morris, Tahnee L Bridson, Md Abdul Alim, Catherine M Rush, Donna M Rudd, Brenda L Govan, Natkunam Ketheesan
The persistent rise in global incidence of type 2 diabetes (T2D) continues to have significant public health and economic implications. The availability of relevant animal models of T2D is critical to elucidating the complexity of the pathogenic mechanisms underlying this disease and the implications this has on susceptibility to T2D complications. Whilst many high-fat diet-induced rodent models of obesity and diabetes exist, growing appreciation of the contribution of high glycaemic index diets on the development of hyperglycaemia and insulin resistance highlight the requirement for animal models that more closely represent global dietary patterns reflective of modern society...
2016: Biology Open
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