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https://www.readbyqxmd.com/read/29098045/something-s-missing-from-my-education-using-a-cross-sectional-survey-to-examine-the-needs-and-interest-of-canadian-medical-students-relating-to-their-roles-as-teachers-and-educators
#1
Alim Nagji, Karen Leslie, Eric Wong, Doug Myhre, Meredith Young, Ming-Ka Chan
Background: Current theory in medical education emphasizes engaging learners as educators while tailoring teaching to their learning needs. However, little is known about learners' perceptions of their proposed roles as teachers and educators. Methods: Canadian medical students were invited to complete an English language online questionnaire structured to include: teaching experience, participation and/or awareness of teacher development at their school and awareness and/or interest in further training in medical education...
June 2017: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/29053638/neuroprotective-surgical-strategies-in-parkinson-s-disease-role-of-preclinical-data
#2
REVIEW
Napoleon Torres, Jenny Molet, Cecile Moro, John Mitrofanis, Alim Louis Benabid
Although there have been many pharmacological agents considered to be neuroprotective therapy in Parkinson's disease (PD) patients, neurosurgical approaches aimed to neuroprotect or restore the degenerative nigrostriatal system have rarely been the focus of in depth reviews. Here, we explore the neuroprotective strategies involving invasive surgical approaches (NSI) using neurotoxic models 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 6-hydroxydopamine (6-OHDA), which have led to clinical trials. We focus on several NSI approaches, namely deep brain stimulation of the subthalamic nucleus, glial neurotrophic derived factor (GDNF) administration and cell grafting methods...
October 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29053310/local-pore-size-correlations-determine-flow-distributions-in-porous-media
#3
Karen Alim, Shima Parsa, David A Weitz, Michael P Brenner
The relationship between the microstructure of a porous medium and the observed flow distribution is still a puzzle. We resolve it with an analytical model, where the local correlations between adjacent pores, which determine the distribution of flows propagated from one pore downstream, predict the flow distribution. Numerical simulations of a two-dimensional porous medium verify the model and clearly show the transition of flow distributions from δ-function-like via Gaussians to exponential with increasing disorder...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29034490/hepatic-complications-of-umbilical-venous-catheters-in-the-neonatal-period-the-ultrasound-spectrum
#4
Betul Emine Derinkuyu, Oznur Leman Boyunaga, Cagri Damar, Sezin Unal, Ebru Ergenekon, Ayse Gul Alimli, Cigdem Oztunali, Canan Turkyilmaz
OBJECTIVES: Umbilical venous catheterization is commonly used in the neonatal period; however, it has some complications. In this study, we evaluated neonates who underwent umbilical venous catheterization and developed hepatic complications. Furthermore, we aimed to define all of the possible lesions and to clarify the imaging findings of umbilical venous catheter-induced hepatic injury. METHODS: Two hundred forty-four neonates who underwent umbilical venous catheterization between March 2013 and September 2015 in a single tertiary care referral center were included in this study...
October 16, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29030695/erratum-to-greater-occipital-nerve-infiltration-under-mr-guidance-feasibility-study-and-preliminary-results
#5
Adrian Kastler, Romain Perolat, Bruno Kastler, Caroline Maindet-Dominici, Jan Fritz, Alim Louis Benabid, Stephan Chabardes, Alexandre Krainik
The original version of this article, published on 12 July 2017, unfortunately contained mistakes. The following corrections have therefore been made in the original.
October 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28989189/mechanistic-kinetic-modeling-of-thiol-michael-addition-photopolymerizations-via-photocaged-superbase-generators-an-analytical-approach
#6
Mauro Claudino, Xinpeng Zhang, Marvin D Alim, Maciej Podgórski, Christopher N Bowman
A kinetic mechanism and the accompanying mathematical framework are presented for base-mediated thiol-Michael photopolymerization kinetics involving a photobase generator. Here, model kinetic predictions demonstrate excellent agreement with a representative experimental system composed of 2-(2-nitrophenyl)propyloxycarbonyl-1,1,3,3-tetramethylguanidine (NPPOC-TMG) as a photobase generator that is used to initiate thiol-vinyl sulfone Michael addition reactions and polymerizations. Modeling equations derived from a basic mechanistic scheme indicate overall polymerization rates that follow a pseudo-first-order kinetic process in the base and coreactant concentrations, controlled by the ratio of the propagation to chain-transfer kinetic parameters (kp/kCT) which is dictated by the rate-limiting step and controls the time necessary to reach gelation...
November 8, 2016: Macromolecules
https://www.readbyqxmd.com/read/28986626/results-of-transurethral-resection-of-the-prostate-in-renal-transplant-recipients-a-single-center-experience
#7
Mehmet Sarier, Sabri Tekin, İbrahim Duman, Yucel Yuksel, Meltem Demir, Furkan Alptekinkaya, Mehmet Guler, Asuman Havva Yavuz, Alim Kosar
OBJECTIVES: The aim of this study was to retrospectively evaluate the early and long-term results of renal transplantation (RT) patients undergoing transurethral resection of the prostate (TURP) due to benign prostate hyperplasia (BPH). MATERIALS AND METHODS: Eighty-nine patients with RT performed in our hospital underwent TURP between November 2008 and March 2016. Results were evaluated along with early and long-term complications. Patients were followed up for a minimum of 12 months...
October 6, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28975451/increased-mast-cell-degranulation-and-co-localization-of-mast-cells-with-the-nmda-receptor-1-during-healing-after-achilles-tendon-rupture
#8
Md Abdul Alim, Paul W Ackermann, Pernilla Eliasson, Parmis Blomgran, Per Kristiansson, Gunnar Pejler, Magnus Peterson
The role of inflammation and the mechanism of tendon healing after rupture has historically been a matter of controversy. The purpose of the present study is to investigate the role of mast cells and their relation to the NMDA receptor-1 (a glutamate receptor) during healing after Achilles tendon rupture. Eight female Sprague Dawley rats had their right Achilles tendon transected. Three weeks after rupture, histological quantification of mast cell numbers and their state of degranulation was assessed by histochemistry...
October 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28972096/pallidal-deep-brain-stimulation-for-dystonia-a-long-term-study
#9
Sara Meoni, Valérie Fraix, Anna Castrioto, Alim Louis Benabid, Eric Seigneuret, Laurent Vercueil, Pierre Pollak, Paul Krack, Eric Chevrier, Stephan Chabardes, Elena Moro
BACKGROUND: Pallidal deep brain stimulation (globus pallidus internus (GPi) DBS) is the best therapeutic option for disabling isolated idiopathic (IID) and inherited (INH) dystonia. Acquired dystonia (AD) may also benefit from GPi DBS. Efficacy and safety in the long-term remained to be established. OBJECTIVE: To retrospectively assess long-term clinical outcomes and safety in dystonic patients who underwent GPi DBS. METHODS: Patients were videotaped and assessed preoperatively and postoperatively (1-year and at last available follow-up) using the Burke-Fahn-Marsden Dystonia Rating Scale (motor score (BFMDRS-M); disability score (BFMDRS-D))...
November 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28966283/asymmetric-aldol-vinylogous-aldol-cyclization-reaction-using-phosphine-oxide-catalysts
#10
Nathan Ray Alim, Shiki Miyazaki, Yasushi Shimoda, Masaharu Sugiura, Makoto Nakajima, Shunsuke Kotani
Chiral phosphine oxide sequentially activates silicon tetrachloride and trichlorosilyl enol ethers to facilitate asymmetric aldol/vinylogous aldol reaction of 4-methoxy-3-penten-2-one and conjugated aldehydes in a highly enantioselective fashion, and the subsequent cyclization produced optically active 2,6-disubstituted 2,3-dihydro-4-pyranones bearing stereogenic centers at a remote position in a single operation.
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28942330/l-shell-differential-cross-section-and-alignment-of-uranium-at-59-54-kev-photon-energy
#11
Tuba Akkuş, Bünyamin Alım, Demet Yılmaz, Yusuf Şahin
L X-ray differential cross-sections of uranium were calculated at several polar scattering angles (85°, 95°, 105°, 115°, 125°, and 135°) at 59.54-keV photon energy by using a Si(Li) detector. We observed that Ll and Lα X-rays were dependent on the polar scattering angle, whereas Lβ and Lγ X-rays were independent of the polar scattering angle. Therefore, the anisotropy parameters for Ll and Lα X-rays were obtained using the intensity ratios of Ll to Lγ X-rays and of Lα to Lγ X-rays to reduce some systematic errors...
July 29, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28886722/tridax-procumbens-flavonoids-a-prospective-bioactive-compound-increased-osteoblast-differentiation-and-trabecular-bone-formation
#12
Md Abdullah Al Mamun, Mohammad Jakir Hosen, Amina Khatun, M Masihul Alam, Md Abdul Alim Al-Bari
BACKGROUND: The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation and bone resorption. The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. However, the effects of the TPF on in vivo bone formation remain unclear...
September 8, 2017: Biological Research
https://www.readbyqxmd.com/read/28878420/comparison-of-methicillin-resistant-staphylococcus-pseudintermedius-adherence-to-2-canine-limb-salvage-endoprosthesis-implants
#13
Alim Nazarali, Ameet Singh, Shauna Morrison, Thomas W G Gibson, Joyce Rousseau, J Scott Weese, Sarah E Boston
The objective of our study was to compare adhesion of methicillin-resistant Staphylococcus pseudintermedius (MRSP) to stainless steel (SS) and to tantalum (TA) canine limb salvage endoprosthesis implants in an in vitro experimental study. The median of the mean log10 colony forming units/mL for adherent MRSP was 4.96 (range: 4.63 to 6.33) for the TA endoprosthesis and 4.31 (range: 3.86 to 5.05) for the SS endoprosthesis (P = 0.009). Although the trabecular and porous design of the TA endoprosthesis provides mechanical benefits over the SS endoprosthesis, it may increase the risk of developing infection due to higher levels of bacterial adherence...
September 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28866461/a-novel-electrochemical-sensor-based-on-calixarene-functionalized-reduced-graphene-oxide-application-to-simultaneous-determination-of-fe-iii-cd-ii-and-pb-ii-ions
#14
Ceren Göde, Mehmet Lütfi Yola, Alime Yılmaz, Necip Atar, Shaobin Wang
A glassy carbon electrode (GCE) modified by calixarene functionalized reduced graphene oxide (CA/RGO) has been fabricated and utilized in this study for simultaneous voltammetric detection of several metal ions, Fe(II), Cd(II) and Pb(II), in aqueous solution. The CA/RGO nanocomposite was characterized in surface and electrochemical properties using scanning electron microscopy (SEM), infrared spectroscopy (IR), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), Raman spectroscopy and electrochemical impedance spectroscopy (EIS)...
August 30, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28768840/thalamic-deep-brain-stimulation-for-tremor-in-parkinson-disease-essential-tremor-and-dystonia
#15
Rubens Gisbert Cury, Valerie Fraix, Anna Castrioto, Maricely Ambar Pérez Fernández, Paul Krack, Stephan Chabardes, Eric Seigneuret, Eduardo Joaquim Lopes Alho, Alim-Louis Benabid, Elena Moro
OBJECTIVE: To report on the long-term outcomes of deep brain stimulation (DBS) of the thalamic ventral intermediate nucleus (VIM) in Parkinson disease (PD), essential tremor (ET), and dystonic tremor. METHODS: One hundred fifty-nine patients with PD, ET, and dystonia underwent VIM DBS due to refractory tremor at the Grenoble University Hospital. The primary outcome was a change in the tremor scores at 1 year after surgery and at the latest follow-up (21 years). Secondary outcomes included the relationship between tremor score reduction over time and the active contact position...
September 26, 2017: Neurology
https://www.readbyqxmd.com/read/28745020/distinct-roles-of-the-7-transmembrane-receptor-protein-rta3-in-regulating-the-asymmetric-distribution-of-phosphatidylcholine-across-the-plasma-membrane-and-biofilm-formation-in-candida-albicans
#16
Archita Srivastava, Shabnam Sircaik, Farha Husain, Edwina Thomas, Shivani Ror, Sumit Rastogi, Darakshan Alim, Priyanka Bapat, David R Andes, Clarissa J Nobile, Sneh L Panwar
Fungal pathogens such as Candida albicans exhibit several survival mechanisms to evade attack by antifungals and colonise host tissues. Rta3, a member of the Rta1-like family of lipid-translocating exporters has a 7-transmembrane domain topology, similar to the G-protein-coupled receptors and is unique to the fungal kingdom. Our findings point towards a role for the plasma membrane localised Rta3 in providing tolerance to miltefosine, an analogue of alkylphosphocholine, by maintaining mitochondrial energetics...
July 25, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28730108/transfer-of-single-dose-of-intravitreal-injection-of-ranibizumab-and-bevacizumab-into-milk-of-sheep
#17
Tugba Cakmak Argun, Ozlem Yalcin Tok, Levent Tok, Gulsen Yilmaz, Fatma Meric Yilmaz, Alime Gunes, Mehmet Argun, Osman Butuner
AIM: To investigate whether single-dose intravitreal injections of bevacizumab and ranibizumab transfer into milk. METHODS: This study included lactating 12 sheep and a single 3-month old suckling lamb of each sheep. Two groups consisting of 6 sheep and their lambs were constituted; the ranibizumab group and the bevacizumab group before the administration of intravitreal injections, blood and milk samples were obtained from all sheep and, following the injections, blood and milk samples of all sheep and blood samples of all lambs were collected at regular time points...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28727388/lysozyme-gene-treatment-in-testosterone-induced-benign-prostate-hyperplasia-rat-model-and-comparasion-of-its-effectiveness-with-botulinum-toxin-injection
#18
Osman Ergün, Pinar Aslan Koşar, İbrahim Onaran, Hakan Darici, Alim Koşar
OBJECTIVES: To compare the effects and histopathological changes of botulinum neurotoxin type A and lysozyme gene injections into prostate tissue within a testosterone induced benign prostate hyperplasia rat model. MATERIALS AND METHODS: 40 male Wistar rats were randomized into four Groups. Group-1: Control, Group-2: Testosterone replacement, Group-3: Testosterone+botulinum neurotoxin type A, Group-4: Testosterone+plazmid DNA/liposome complex. RESULTS: Estimated prostate volume of the testosterone injected Groups were higher than the control (p <0...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28710082/accuracy-and-precision-of-venous-pressure-measurements-of-endovascular-microcatheters-in-the-setting-of-dural-venous-sinus-stenosis
#19
Michael B Avery, Sheryl Sambrano, Javed Khader Eliyas, Muneer Eesa, Alim P Mitha
INTRODUCTION: Dural venous sinus stenosis (DVSS) may lead to increased intracranial pressure, sometimes requiring a stent if a high pressure gradient exists. Many neuroendovascular physicians use microcatheters to measure gradients, yet there are no studies comparing the accuracies and precisions of modern day microcatheters. We examined pressure recordings from five commonly used microcatheters in an experimental DVSS model. METHODS: Using a programmable pump, dynamic flow was established in a closed circuit mimicking the venous sinus waveform...
July 14, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28702799/greater-occipital-nerve-infiltration-under-mr-guidance-feasibility-study-and-preliminary-results
#20
Adrian Kastler, Romain Perolat, Bruno Kastler, Caroline Maindet-Dominici, Jan Fritz, Alim Louis Benabid, Stephan Chabardes, Alexandre Krainik
OBJECTIVE: To assess the feasibility of greater occipital nerve (GON) intermediate site infiltration with MRI guidance. METHODS: Eleven consecutive patients suffering from chronic refractory cranio-facial pain who underwent 16 GON infiltrations were included in this prospective study. All of the procedures were performed on an outpatient basis in the research facility of our institution, with a 1.5 T scanner. The fatty space between inferior obliquus and semispinalis muscles at C1-C2 level was defined as the target...
July 12, 2017: European Radiology
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