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Asthma COPD Overlap Syndrome (ACOS)

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https://www.readbyqxmd.com/read/29588581/maintenance-inhaler-preference-attribute-importance-and-satisfaction-in-prescribing-physicians-and-patients-with-asthma-copd-or-asthma-copd-overlap-syndrome-consulting-for-routine-care
#1
Bo Ding, Mark Small, Gina Scheffel, Ulf Holmgren
Background: In respiratory disorders, patient- and physician-perceived satisfaction with the maintenance inhaler device is an important factor driving treatment compliance and outcomes. We examine inhaler preferences in asthma and COPD from patient and physician perspectives, particularly focusing on the relative importance of individual device attributes and patient characteristics guiding inhaler choice. Materials and methods: Real-world data from >7,300 patients with asthma, COPD, or asthma-COPD overlap syndrome (ACOS) consulting for routine care were derived from respiratory Disease Specific Programs conducted in Europe, USA, Japan, and China...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29559773/use-of-clinical-characteristics-to-predict-spirometric-classification-of-obstructive-lung-disease
#2
Steven J Pascoe, Wei Wu, Kathryn A Collison, Linda M Nelsen, Keele E Wurst, Laurie A Lee
Background: There is no consensus on how to define patients with symptoms of asthma and chronic obstructive pulmonary disease (COPD). A diagnosis of asthma-COPD overlap (ACO) syndrome has been proposed, but its value is debated. This study (GSK Study 201703 [NCT02302417]) investigated the ability of statistical modeling approaches to define distinct disease groups in patients with obstructive lung disease (OLD) using medical history and spirometric data. Methods: Patients aged ≥18 years with diagnoses of asthma and/or COPD were categorized into three groups: 1) asthma (nonobstructive; reversible), 2) ACO (obstructive; reversible), and 3) COPD (obstructive; nonreversible)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29550368/asthma-and-copd-overlap-pathophysiology-of-aco
#3
REVIEW
Mari Hikichi, Shu Hashimoto, Yasuhiro Gon
Asthma and COPD appear as a result of different mechanisms triggered by different pathogeneses and although they present different features and symptoms of airway inflammation and airway obstruction, there are also cases that present the features of both asthma and COPD. This type of pathology is known as asthma-COPD overlap syndrome (ACOS). Asthma-COPD overlap is identified in clinical practice by the features that it shares with both asthma and COPD. This is not a definition, but a description for clinical use, as asthma-COPD overlap includes several different clinical phenotypes and there are likely to be several different underlying mechanisms"...
March 14, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29527840/increased-risk-of-exacerbation-in-asthma-predominant-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#4
Jisoo Park, Eun Kyung Kim, Mi Ae Kim, Tae Hyung Kim, Jung Hyun Chang, Yon Ju Ryu, Sei Won Lee, Yeon Mok Oh, Suk Joong Yong, Won Il Choi, Kwang Ha Yoo, Ji Hyun Lee
BACKGROUND: Obstructive airway disease patients with increased variability of airflow and incompletely reversible airflow obstruction are often categorized as having asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS). ACOS is heterogeneous with two sub-phenotypes: asthma-ACOS and COPD-ACOS. The objective of this study was to determine the difference in risk of exacerbation between the two sub-phenotypes of ACOS. METHODS: A total of 223 patients exhibiting incompletely reversible airflow obstruction with increased variability (spirometrically defined ACOS) were enrolled...
March 7, 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29487249/predictors-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-patients-with-chronic-obstructive-pulmonary-disease-from-a-tertiary-care-center-in-india
#5
Irfan Ismail Ayub, Abdul Majeed Arshad, Prathipa Sekar, Natraj Manimaran, Dhanasekar Thangaswamy, Chandrasekar Chockalingam
Background: There is dearth of literature on asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) in India. The aim was to compare clinical characteristics between patients with ACOS and non-ACOS COPD and to identify clinical predictors of ACOS in patients with COPD. Methods: We conducted a retrospective study by reviewing data collected from patients performing spirometry at our hospital. Those with postbronchodilator FEV1 /FVC <70% were included in the study...
March 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29158762/the-asthma-copd-overlap-syndrome-acos-epidemiology-and-historical-perspective
#6
Maarten van den Berge
No abstract text is available yet for this article.
2017: Tanaffos
https://www.readbyqxmd.com/read/29158759/the-asthma-copd-overlap-syndrome-acos-epidemiology-and-historical-perspective
#7
Maarten van den Berge
No abstract text is available yet for this article.
2017: Tanaffos
https://www.readbyqxmd.com/read/29138407/spirometry-is-not-enough-to-diagnose-copd-in-epidemiological-studies-a-follow-up-study
#8
Elena Andreeva, Marina Pokhaznikova, Anatoly Lebedev, Irina Moiseeva, Olga Kuznetsova, Jean-Marie Degryse
A hallmark of the diagnosis of chronic obstructive pulmonary disease (COPD) is the measurement of post-bronchodilator (post-BD) airflow obstruction (AO) by spirometry, but spirometry is not enough for the provision of a clinical diagnosis. In the majority of previous epidemiological studies, COPD diagnosis has been based on spirometry and a few clinical characteristics. The aim of our study was to identify outcomes in patients newly diagnosed with airflow obstruction (AO) based on a diagnostic work-up conducted as part of a population-based cross-sectional study in North-Western Russia...
November 14, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29094021/the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-tertiary-care-setting-thailand
#9
Theerasuk Kawamatawong, Sanruethai Charoenniwassakul, Ticha Rerkpattanapipat
Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized clinical entity. ACOS significantly impacts on patient outcome compared to isolated asthma or COPD. However, ACOS definition and diagnosis criteria have not been well standardized. ACOS prevalence and clinical features in Thailand has never been studied. Objective: To investigate the prevalence and clinical features of ACOS compared to isolated asthma or COPD among patients with clinician-diagnosis of obstructive airway diseases...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28982831/association-of-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-with-coronary-artery-disease-cardiac-dysrhythmia-and-heart-failure-a-population-based-retrospective-cohort-study
#10
Jun-Jun Yeh, Yu-Feng Wei, Cheng-Li Lin, Wu-Huei Hsu
OBJECTIVES: Patients with asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) and cardiovascular diseases (CVDs) share common risk factors. However, the association between ACOS and the incidence of CVDs has not been reported. This study investigated the relationship between CVDs and ACOS in the general population. SETTING: Data were obtained from Taiwan's National Health Insurance Research Database for the period 2000 to 2010. PARTICIPANTS: The ACOS cohort comprised patients (n=5814) who had received a diagnosis of asthma and COPD...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28947632/asthma-copd-overlap-syndrome-pathogenesis-clinical-features-and-therapeutic-targets
#11
REVIEW
Janice M Leung, Don D Sin
Asthma-COPD overlap syndrome (ACOS) or asthma-COPD overlap captures the subset of patients with airways disease who have features of both asthma and chronic obstructive pulmonary disease (COPD). Although definitions of ACOS vary, it is generally thought to encompass persistent airflow limitation in a patient older than 40 years of age with either a history of asthma or large bronchodilator reversibility. ACOS affects about a quarter of patients with COPD and almost a third of patients who previously had asthma...
September 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28862414/asthma-copd-overlap-syndrome-recent-advances-in-diagnostic-criteria-and-prognostic-significance
#12
REVIEW
Claudio Sorino, Nicola Scichilone, Maria D'Amato, Vincenzo Patella, Fabiano DI Marco
The term asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) has been proposed for individuals with features of both asthma and COPD. Several attempts have been done to define ACOS on the basis of medical history, symptoms, and functional findings. The main diagnostic criteria include airflow obstruction with a strong although incomplete reversibility to bronchodilation tests, a significant exposure to cigarette or biomass smoke, and a history of atopy or asthma. Additional diagnostic elements include eosinophilic airway and systemic inflammation, a good response to corticosteroid treatment, and a high concentration of exhaled nitric oxide...
June 2017: Minerva Medica
https://www.readbyqxmd.com/read/28860740/clinical-implications-of-blood-eosinophil-count-in-patients-with-non-asthma-copd-overlap-syndrome-copd
#13
Jin Hwa Song, Chang-Hoon Lee, Jin Woo Kim, Won-Yeon Lee, Ji Ye Jung, Joo Hun Park, Ki Suck Jung, Kwang Ha Yoo, Yong Bum Park, Deog Keom Kim
BACKGROUND: Recent studies that assessed the relevance of the blood eosinophil count as a biomarker in patients with COPD may have overestimated it because they included patients with asthma-COPD overlap syndrome (ACOS). We investigated the clinical implications of the blood eosinophil count in patients with non-ACOS COPD. PATIENTS AND METHODS: From a Korean COPD Subtype Study (KOCOSS) cohort, we selected patients with non-ACOS COPD after excluding ACOS patients according to Spanish criteria...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28790809/clinical-characteristics-of-chronic-bronchitic-emphysematous-and-acos-phenotypes-in-copd-patients-with-frequent-exacerbations
#14
Yusheng Cheng, Xiongwen Tu, Linlin Pan, Shuai Lu, Ming Xing, Linlin Li, Xingwu Chen
PURPOSE: Chronic bronchitis (CB), emphysematous (EM) and asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) phenotypes in COPD are well recognized. This study aimed to investigate distinguishing characteristics of these phenotypes in COPD patients with frequent exacerbations (FE). PATIENTS AND METHODS: A retrospective study was carried out. COPD patients with acute exacerbations were consecutively reviewed from November 2015 to October 2016...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28740668/socioeconomic-impact-of-asthma-chronic-obstructive-pulmonary-disease-and-asthma-copd-overlap-syndrome
#15
Jinhee Kim, Young Sam Kim, Kyungjoo Kim, Yeon-Mok Oh, Kwang Ha Yoo, Chin Kook Rhee, Jin Hwa Lee
BACKGROUND: Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is defined as having both features of asthma and COPD, which are airway hyper-responsiveness and incompletely reversible airway obstruction. However, socioeconomic impact of ACOS have not been well appreciated. METHODS: Adults with available wheezing history and acceptable spirometry were selected from the fourth Korean National Health and Nutrition Examination Survey (KNHANES IV) in 2007-2009...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740378/active-smoking-and-copd-phenotype-distribution-and-impact-on-prognostic-factors
#16
Juan Antonio Riesco, Bernardino Alcázar, Juan Antonio Trigueros, Anna Campuzano, Joselín Pérez, José Luis Lorenzo
PURPOSE: Smoking can affect both the phenotypic expression of COPD and factors such as disease severity, quality of life, and comorbidities. Our objective was to evaluate if the impact of active smoking on these factors varies according to the disease phenotype. PATIENTS AND METHODS: This was a Spanish, observational, cross-sectional, multicenter study of patients with a diagnosis of COPD. Smoking rates were described among four different phenotypes (non-exacerbators, asthma-COPD overlap syndrome [ACOS], exacerbators with emphysema, and exacerbators with chronic bronchitis), and correlated with disease severity (body mass index, obstruction, dyspnea and exacerbations [BODEx] index and dyspnea grade), quality of life according to the COPD assessment test (CAT), and presence of comorbidities, according to phenotypic expression...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28701317/redefining-the-overlap-of-asthma-and-copd
#17
(no author information available yet)
The term asthma-COPD overlap (ACO) has been suggested for people with chronic airflow obstruction that has features characteristic of both asthma and chronic obstructive pulmonary disease (COPD).1 People with clinical features of asthma and COPD tend to have worse outcomes than those with either asthma or COPD alone, yet their clinical management has remained unclear. UK guidelines currently do not specifically address this issue,2,3 but the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) have published a consensus-based report on the diagnosis and treatment of people with asthma, COPD and ACO...
July 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28694694/expression-profiling-of-mirna-145-and-mirna-338-in-serum-and-sputum-of-patients-with-copd-asthma-and-asthma-copd-overlap-syndrome-phenotype
#18
Donato Lacedonia, Grazia Pia Palladino, Maria Pia Foschino-Barbaro, Giulia Scioscia, Giovanna Elisiana Carpagnano
BACKGROUND AND OBJECTIVES: A new phenotype with overlapping characteristics between asthma and chronic obstructive pulmonary disease (COPD) called asthma-COPD overlap syndrome (ACOS) is emerging among inflammation diseases. To date, there is no agreement on specific criteria to define this syndrome, and the current guidelines are insufficient to classify the analogy and differences between overlap and COPD or asthma phenotypes. It would be necessary to identify new biomarkers able to identify these diseases clearly...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28694693/prevalence-and-characteristics-of-asthma-copd-overlap-syndrome-identified-by-a-stepwise-approach
#19
Hiromasa Inoue, Takahide Nagase, Satoshi Morita, Atsushi Yoshida, Tatsunori Jinnai, Masakazu Ichinose
BACKGROUND AND OBJECTIVE: There is increasing recognition of asthma-COPD overlap syndrome (ACOS), which shares some features of both asthma and COPD; however, the prevalence and characteristics of ACOS are not well understood. The aim of this study was to investigate the prevalence of ACOS among patients with COPD and its characteristics using a stepwise approach as stated in the recent report of the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28677357/asthma-copd-overlap-shows-favorable-clinical-outcomes-compared-to-pure-copd-in-a-korean-copd-cohort
#20
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Chul Min Ahn, Jin Hwa Lee, Kyeong Cheol Shin, Soo Taek Uh, Seung Won Ra, Kwang Ha Yoo, Ki Suck Jung
PURPOSE: Comparisons of the characteristics of chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) have been the focus of several studies since the diseases were defined by the Global Initiative for Asthma and Global Initiative for Chronic Obstructive Lung Disease guidelines. However, no consensus is available yet. In this study, we aimed to compare the characteristics of asthma-COPD overlap (ACO) and COPD. METHODS: We retrospectively reviewed 1,504 patients with COPD in a Korean COPD Subtype Study cohort...
September 2017: Allergy, Asthma & Immunology Research
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