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https://www.readbyqxmd.com/read/29140932/characteristics-of-treatment-experienced-hiv-infected-african-children-and-adolescents-initiating-darunavir-and-or-etravirine-based-antiretroviral-treatment
#1
Bethany Corrigan, Irene Mukui, Lloyd Mulenga, Nobuhle Mthethwa, Mosilinyane Letsie, Stephanie Bruno, Natella Rakhmanina
BACKGROUND: Data are limited on the selection and sequencing of second and third-line pediatric antiretroviral treatment (ART) in resource-limited settings. This study aimed to evaluate characteristics of African pediatric patients initiated on darunavir (DRV) and/or etravirine (ETR) through a specific drug donation program. METHODS: This was a cross-sectional study of baseline immunologic, virologic and demographic characteristics of children and adolescents initiating DRV- and/or ETR-based ART...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29140757/new-insights-into-lymphoma-pathogenesis
#2
Kojo S J Elenitoba-Johnson, Megan S Lim
Lymphomas represent clonal proliferations of lymphocytes that are broadly classified based upon their maturity (peripheral or mature versus precursor) and lineage (B cell, T cell, and natural killer cell). Insights into the pathogenetic mechanisms involved in lymphoma impact the classification of lymphoma and have significant implications for the diagnosis and clinical management of patients. Serial scientific and technologic advances over the last 30 years in immunology, cytogenetics, molecular biology, gene expression profiling, mass spectrometry-based proteomics, and, more recently, next-generation sequencing have contributed to greatly enhance our understanding of the pathogenetic mechanisms in lymphoma...
November 15, 2017: Annual Review of Pathology
https://www.readbyqxmd.com/read/29138308/sex-reporting-in-preclinical-microbiological-and-immunological-research
#3
EDITORIAL
Tanvi Potluri, Kyrra Engle, Ashley L Fink, Landon G Vom Steeg, Sabra L Klein
Both sex (i.e., biological construct of male and female) and gender (i.e., social construct of masculine and feminine) impact the pathogenesis of diseases, including those caused by microbial infections. Following the 2015 NIH policy for consideration of sex as a biological variable in preclinical research, in 2018, authors of papers published in primary-research American Society for Microbiology (ASM) journals will be asked to report the sex of the research subjects and animals and of materials derived directly from them...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29127996/highlights-in-immune-response-microbiome-and-precision-medicine-in-allergic-disease-and-asthma
#4
EDITORIAL
Milena Sokolowska, Cezmi A Akdis
Several recent key findings in immunology of allergic diseases that have led to a need of reassessment of our current thinking are reviewed in this issue of the journal. Recently developed strong evidence on the role of hygiene hypothesis in protection from allergic disease and its immune mechanisms is reviewed by Ober et al. The authors pointed out immunologic mechanisms of lower prevalence of asthma and allergic sensitization observed among Amish children living on traditional farms with higher endotoxin levels as compared to Hutterite children living on industrialized farms...
October 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29123260/combining-dna-damaging-therapeutics-with-immunotherapy-more-haste-less-speed
#5
REVIEW
Jessica S Brown, Raghav Sundar, Juanita Lopez
The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion of DNA damaging agents may actually promote immunogenic cell death, alter the inflammatory milieu of the tumour microenvironment and/or stimulate neoantigen production, thereby activating an antitumour immune response...
November 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29114880/maintenance-of-memory-cd8-t-cells-divided-over-division
#6
Martijn A Nolte, Marieke Goedhart, Jens Geginat
Once generated during an infection, memory CD8(+) T cells can provide long-lasting protection against reinfection with an intracellular pathogen, but the longevity of this defense depends on the ability of these pathogen-specific memory cells to be maintained. It is generally believed that the bone marrow plays an important role in this respect, where memory CD8 T cells receive reinvigorating signals from cytokines that induce homeostatic proliferation. However, in the current issue of the European Journal of Immunology, Siracusa et al...
November 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29099676/molecular-and-genomic-determinants-of-response-to-immune-checkpoint-inhibition-in-cancer
#7
Russell W Jenkins, Rohit Thummalapalli, Jacob Carter, Israel Cañadas, David A Barbie
Molecularly targeted therapy and immunotherapy have dramatically changed the landscape of available treatment options for patients with advanced cancer. Improved understanding of the molecular and genomic features of cancers over the last decade has led to the development of successful targeted therapies and the field of precision cancer medicine. As a result of these advances, patients whose tumors harbor select molecular alterations are eligible for treatment with targeted therapies active against the unique molecular aberration...
November 3, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/29070528/the-legacy-of-cvi
#8
Marcela F Pasetti, Steven D Douglas, Susan F Plaeger
Clinical and Vaccine Immunology (CVI) will be merged with the ASM open-access journal mSphere in January 2018. We commemorate this transition by exploring the history of CVI and its predecessor Clinical and Diagnostic Laboratory Immunology (CDLI) and by acknowledging their contributors. Research on vaccine, clinical immunology, and clinical diagnostic immunology published through mSphere will be available to an ever larger audience and facilitate progress in field. The ASM remains committed to supporting its members and the research community facilitating the dissemination of scientific knowledge in these important areas...
October 25, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29068046/gpr35-mediates-lodoxamide-induced-migration-inhibitory-response-but-not-cxcl17-induced-migration-stimulatory-response-in-thp-1-cells-is-gpr35-a-receptor-for-cxcl17
#9
Soo-Jin Park, Seung-Jin Lee, So-Yeon Nam, Dong-Soon Im
GPR35 has long been considered an orphan G protein-couple receptor, and although no endogenous ligand of GPR35 has been discovered, synthetic agonists and antagonists have been developed. CXCL17 (a chemokine) has been reported to be an endogenous ligand of GPR35, and it has even been suggested that it be called CXCR8 (Journal of Immunology 2015; 194:29-33). However, no supporting report on the CXCL17-GPR35 relation has been issued since, although GPR35 is supposed to be a potential therapeutic target in several pathologic conditions...
October 25, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29067711/food-allergy-in-eaaci-journals-2016
#10
REVIEW
Ulrich Wahn, Paolo M Matricardi, Thomas Bieber, Jean Bousquet, Clive Grattan, Hans-Uwe Simon, Antonella Muraro, Ioana Agache
The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to understand and better manage food allergy, and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members (1). The European Symposium on Precision Medicine in Allergy and Airways Diseases at the European Union Parliament (October 14, 2015) stressed that the socioeconomic impact of food allergy (2)...
October 25, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29045815/eosinophils-and-eosinophil-associated-diseases-an-update
#11
Jeremy A O'Sullivan, Bruce S Bochner
The goal of this series is to offer a survey of the latest literature for clinicians and scientists alike, providing a list of important recent advances relevant to the broad field of allergy and immunology. This particular assignment was to cover the topic of eosinophils. In an attempt to highlight major ideas, themes, trends and advances relevant to basic and clinical aspects of eosinophil biology, a search of papers published since 2015 in JACI and other high impact journals was performed. Manuscripts were then reviewed and organized, and then key findings were summarized...
October 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29043909/british-journal-of-biomedical-science-in-2017-what-have-we-learned
#12
Andrew Blann
In 2017 the British Journal of Biomedical Science published 35 articles in the various disciplines that comprise biomedical science. These were 6 reviews, 22 original articles, 6 'In Brief' short reports and one guideline. Of these, the majority were in clinical chemistry (one review, six data papers), microbiology (one review, four data papers), cellular pathology (four data papers) and virology (one review, two data papers). There were two data papers in transfusion science, whilst haematology, cytopathology and immunology were each represented by one review and one data paper...
October 18, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29032355/first-person-olivia-susanto
#13
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Olivia Susanto is the first author on 'LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells', published in Journal of Cell Science. Olivia is a postdoctoral researcher in the lab of Prof. Robert Insall at the Beaton Institute in Glasgow, UK, where she focuses on imaging live cell interactions and cell migration both in vivo and in vitro, in cell biology and immunology...
October 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29025851/investigating-bordetella-pertussis-colonisation-and-immunity-protocol-for-an-inpatient-controlled-human-infection-model
#14
Hans de Graaf, Diane Gbesemete, Andrew R Gorringe, Dimitri A Diavatopoulos, Kent E Kester, Saul N Faust, Robert C Read
INTRODUCTION: We summarise an ethically approved protocol for the development of an experimental human challenge colonisation model. Globally Bordetella pertussis is one of the leading causes of vaccine-preventable death. Many countries have replaced whole cell vaccines with acellular vaccines over the last 20 years during which pertussis appears to be resurgent in a number of countries in the developed world that boast high immunisation coverage. The acellular vaccine provides relatively short-lived immunity and, in contrast to whole cell vaccines, may be less effective against colonisation and subsequent transmission...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28945976/social-immunity-emergence-and-evolution-of-colony-level-disease-protection
#15
Sylvia Cremer, Christopher D Pull, Matthias A Fürst
Social insect colonies have evolved many collectively performed adaptations that reduce the impact of infectious disease and that are expected to maximize their fitness. This colony-level protection is termed social immunity, and it enhances the health and survival of the colony. In this review, we address how social immunity emerges from its mechanistic components to produce colony-level disease avoidance, resistance, and tolerance. To understand the evolutionary causes and consequences of social immunity, we highlight the need for studies that evaluate the effects of social immunity on colony fitness...
September 25, 2017: Annual Review of Entomology
https://www.readbyqxmd.com/read/28926600/publication-trends-of-research-on-diabetes-mellitus-and-t-cells-1997-2016-a-20-year-bibliometric-study
#16
Ye Gao, Yiran Wang, Xiao Zhai, Yifei He, Rong Chen, Jingjing Zhou, Ming Li, Qijin Wang
INTRODUCTION: Diabetes Mellitus (DM) is a huge burden for human health. Recent studies show the close relationship between DM and T cells. We investigated the trend in DM and T cells research. METHODS: Using the Web of Science database, we searched the publications on DM and T cells in 1997-2016, and studied the source data using bibliometric methodology. Excel 2016, GraphPad Prism 5, and VOSviewer software were used to analyze the publication trend in DM and T cells research...
2017: PloS One
https://www.readbyqxmd.com/read/28926357/first-in-human-treatment-with-a-dendritic-cell-targeting-lentiviral-vector-expressing-ny-eso-1-lv305-induces-deep-durable-response-in-refractory-metastatic-synovial-sarcoma-patient
#17
Seth M Pollack, Hailing Lu, Sacha Gnjatic, Neeta Somaiah, Ryan B O'Malley, Robin L Jones, Frank J Hsu, Jan Ter Meulen
Effective induction of antitumor T cells is a pivotal goal of cancer immunotherapy. To this end, lentiviral vectors (LV) are uniquely poised to directly prime CD8 T-cell responses via transduction of dendritic cells in vivo and have shown promise as active cancer therapeutics in preclinical tumor models. However, until now, significant barriers related to production and regulation have prevented their widespread use in the clinic. We developed LV305, a dendritic cell-targeting, integration-deficient, replication incompetent LV from the ZVex platform, encoding the full-length cancer-testis antigen NY-ESO-1...
September 18, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28891156/overcoming-preexisting-alloantibody-in-renal-transplantation-improving-outcomes-while-reducing-needs-and-costs
#18
EDITORIAL
A Bentall, Solomon J Cohney
No abstract text is available yet for this article.
December 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28877002/lymphedema-pathogenesis-and-novel-therapies
#19
Joseph H Dayan, Catherine L Ly, Raghu P Kataru, Babak J Mehrara
Lymphedema affects up to 1 in 6 patients who undergo treatment for a solid tumor in the United States. Its prevalence has increased as more effective oncologic therapies have improved patient survival, but there remains no definitive cure. Recent research has elucidated new details in the pathogenesis of the disease and has demonstrated that it is fundamentally an immunologic progress that ultimately results in inflammation, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping...
September 6, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28845904/spreading-the-load-antigen-transfer-between-migratory-and-lymph-node-resident-dendritic-cells-promotes-t-cell-priming
#20
Scott N Mueller
Dendritic cells (DC) are specialized in the processing and presentation of antigen for the activation of lymphocytes. Multiple subsets of DCs exist with distinct functions and roles in the initiation of immune responses. DCs found within tissues acquire antigens or become infected by pathogens and migrate to local draining lymph nodes (LN) where they can directly stimulate T cells. These migratory DCs can also transfer antigens to LN-resident DCs and may indirectly enhance T cell priming. In this issue of the European Journal of Immunology, Gurevich et al...
October 2017: European Journal of Immunology
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