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journal of immunology

Petter Höglund
No abstract text is available yet for this article.
September 2018: Scandinavian Journal of Immunology
Rick Bucala, Marian Hannan
The founding of Arthritis & Rheumatism by the American Rheumatism Association in 1958 occurred at the advent of knowledge of immunologic abnormalities in patients with rheumatoid arthritis, SLE, and related disorders. Over its ensuing 60 year history, "A&R" (renamed to Arthritis & Rheumatology in 2014) developed into a preeminent publication for disseminating research findings and advancing the field scientifically. Landmark papers included the role of autoantibodies and lymphocytes in rheumatic diseases and, in recent years, the clinical translation of cell and cytokine-based paradigms of disease...
September 10, 2018: Arthritis Care & Research
Hitesh Deshmukh, Sing Sing Way
Pregnancy stimulates an elaborate assortment of dynamic changes, allowing intimate approximation of genetically discordant maternal and fetal tissues. Although the cellular and molecular details about how this works remain largely undefined, important clues arise from evaluating how a prior pregnancy influences the outcome of a future pregnancy. The risk of complications is consistently increased when complications occurred in a prior pregnancy. Reciprocally, a prior successful pregnancy protects against complications in a future pregnancy...
September 5, 2018: Annual Review of Pathology
Tom Cupedo
The relevance of innate lymphoid cells (ILC) for anti-infectious immunity remains a matter of constant debate. At the same time, evidence for additional, non-immune related functions of ILC is steadily increasing. In the thymus, non-immune functions of ILC were shown for group 3 ILC (ILC3), which regulate differentiation and proliferation of thymic epithelial cells. In this issue of the European Journal of Immunology, Withers and colleagues [Eur. J. Immunol. 2018. 48: 1481-1491] now show that ILC2, a subset of ILCs specialized in tissue protection and regeneration, are the major ILC subset in the adult thymus, heavily outnumbering ILC3...
September 2018: European Journal of Immunology
Adriana Ammassari, Wolfgang Stöhr, Andrea Antinori, Jean-Michel Molina, Christine Schwimmer, Pere Domingo, Anders Thalme, Massimo Di Pietro, Cedrick Wallet, Anton Pozniak, Laura Richert, François Raffi
BACKGROUND: The NEAT 001/ANRS 143 trial demonstrated non-inferiority of darunavir-ritonavir combined with either raltegravir (RAL+DRV/r) or tenofovir disoproxil fumarate/emtricitabine (TDF/FTC+DRV/r) in HIV-positive, antiretroviral-naive adults. In post-hoc analyses however, RAL+DRV/r showed inferiority in patients with baseline CD4+ <200/mm and HIV-1 RNA ≥100,000 copies/mL. This pre-planned ancillary study was conducted to assess whether differences in adherence might explain efficacy results SETTING:: Phase III, open-label, randomized, multicentre study in 15 European countries (ClinicalTrials...
August 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Lutz Bornmann, Adam Y Ye, Fred Y Ye
"Hot papers" (HPs) are papers which received a boost of citations shortly after publication. Papers with "delayed recognition" (DRs) received scarcely impact over a long time period, before a considerable citation boost started. DRs have attracted a lot of attention in scientometrics and beyond. Based on a comprehensive dataset with more than 5,000,000 papers published between 1980 and 1990, we identified HPs and DRs. In contrast to many other studies on DRs, which are based on raw citation counts, we calculated dynamically field-normalized impact scores for the search of HPs and DRs...
2018: Scientometrics
Michael Karsy, Mohammed A Azab, Jian Guan, William T Couldwell, John D Rolston
BACKGROUND: The use of bibliometrics to evaluate authors, institutions, and journals faces significant challenges in comparing biomedical specialties because of marked differences among fields. Our objective was to evaluate the effect of specialty field and physician numbers on bibliometric parameters. METHODS: For this bibliometric analysis, data from and SCImago Journal & Country Rank for 2016 were used to rank the journals. The 2015 Physician Specialty Data Report provided the number of specialists in specific fields...
August 23, 2018: World Neurosurgery
Enrico Lugli, Jolanda Brummelman, Karolina Pilipow, Rahul Roychoudhuri
Interferon regulatory factor 4 (IRF4) regulates the clonal expansion and metabolic activity of activated T cells, but the precise context and mechanisms of its function in these processes are unclear. In this issue of the European Journal of Immunology, Miyakoda et al. [Eur. J. Immunol. 2018. 48: 1319-1328] show that IRF4 is required for activation and expansion of naïve and memory CD8+ T cells driven by T-cell receptor (TCR) signaling, but dispensable for memory CD8+ T-cell maintenance and homeostatic proliferation driven by homeostatic cytokines...
August 2018: European Journal of Immunology
Laura Ridolfi, Francesco de Rosa, Laura Fiammenghi, Massimiliano Petrini, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Jenny Bulgarelli, Angela Riccobon, Giorgia Gentili, Oriana Nanni, Massimo Framarini, Francesca Tauceri, Massimo Guidoboni
INTRODUCTION: Surgery is one of the treatments of choice for patients with a single metastasis from melanoma but is rarely curative. Such patients could potentially benefit from consolidation immunotherapy. Vaccination with dendritic cells (DCs) loaded with tumour antigens elicits a tumour-specific immune response. In our experience, patients who developed delayed type hypersensitivity (DTH) after DC vaccination showed a median overall survival (OS) of 22.9 monthsvs4.8 months for DTH-negative cases...
August 5, 2018: BMJ Open
Jelmer R Prins, Floor Holvast, Janneke van 't Hooft, Arend F Bos, Jan Willem Ganzevoort, Sicco A Scherjon, Sarah A Robertson, Sanne J Gordijn
INTRODUCTION: To establish pregnancy, the maternal immune system must adapt to tolerate the semiallogenic fetus. Less than optimal adaptation of the maternal immune system during (early) pregnancy is implicated in several complications of pregnancy. The development of effective immune modulation interventions as preventive or therapeutic strategies for pregnancy complications holds promise. Several studies sought to evaluate the safety and effectiveness of various approaches. However, a limitation is the high variability in clinical and immune outcomes that are reported...
August 5, 2018: BMJ Open
Carlo Selmi
The number of peer-reviewed articles published during the 2017 solar year and retrieved using the "autoimmunity" key word increased significantly compared to 2016 while maintaining a stable share within the immunology field, following years with alternated fortunes. A detailed arbitrary analysis of the published articles in leading immunology and autoimmunity journals provides a privileged viewpoint on the current trends of research from both basic and clinical studies. Indeed, we are observing that major steps forward are found for rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, among others...
July 26, 2018: Clinical Reviews in Allergy & Immunology
George A Mensah, James P Kiley, Gary H Gibbons
Asthma is the most prevalent chronic respiratory disease worldwide. Its increasing prevalence and evidence of suboptimal control require renewed efforts in the development and widespread implementation of clinical practice guidelines for prevention, treatment, and control. Given the rapidly changing landscape and evolving best practices for guideline development, the National Heart, Lung, and Blood Institute made a commitment to support rigorous systematic evidence reviews that frontline health care providers and stakeholders could use to create new or update existing guidelines...
September 2018: Journal of Allergy and Clinical Immunology
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Bertrand Tchana, Giuliana Valerio, Alberto Verrotti, Mariella Valenzise, Sergio Bernasconi, Giovanni Corsello
This review provides an overview of a remarkable number of significant studies in pediatrics that have been published over the past year in the Italian Journal of Pediatrics. We have selected information from papers presented in the Journal that deal with allergy, endocrinology, gastroenterology, genetics, immunology, infectious diseases, neonatology, nephrology, neurology, pulmonology. The relevant epidemiologic findings, and developments in prevention, diagnosis and treatment of the last year have been discussed and placed in context...
July 17, 2018: Italian Journal of Pediatrics
Christiane Ruedl, Steffen Jung
Cell ablation is a valuable complement to mutagenesis for experimentally defining specific cell functions in physiology and pathophysiology in small animal models. One of the most popular ablation strategies involves transgenic expression of a primate diphtheria toxin receptor (DTR) on murine cells that are otherwise resistant to the bacterial exotoxin. The efforts of many laboratories using the DTR approach over the years have yielded numerous valuable insights into specific cell functions. Here, we will discuss the technical aspects of the DTR approach, including the strengths, pitfalls, and future strategies to overcome the shortcomings, highlighting a recent paper published in the European Journal of Immunology [El Hachem et al...
July 2018: European Journal of Immunology
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No abstract text is available yet for this article.
2018: Journal of Oral Microbiology
Waqas Haque, Abu Minhajuddin, Arjun Gupta, Deepak Agrawal
BACKGROUND: Almost all medical journals now require authors to publicly disclose conflicts of interests (COI). The same standard and scrutiny is rarely employed for the editors of the journals although COI may affect editorial decisions. METHODS: We conducted a retrospective observational study to determine the prevalence and magnitude of financial relationships among editors of 60 influential US medical journals (10 each for internal medicine and five subspecialties: cardiology, gastroenterology, neurology, dermatology and allergy & immunology)...
2018: PloS One
Brian Ezekian, Paul M Schroder, Kyle Freischlag, Janghoon Yoon, Jean Kwun, Stuart J Knechtle
The purpose of this review is to discuss immunologic tolerance as it applies to solid organ transplantation and to identify barriers that hinder the achievement of this long-term goal. First, the definition of tolerance and an introduction of mechanisms by which tolerance exists or can be achieved will be discussed. Next, a review of contemporary attempts at achieving transplant tolerance will be described. Finally, a discussion of the humoral barriers to transplantation tolerance and potential ways to overcome these barriers will be presented...
August 2018: Transplantation
Anna Pomés, Janet M Davies, Gabriele Gadermaier, Christiane Hilger, Thomas Holzhauser, Jonas Lidholm, Andreas L Lopata, Geoffrey A Mueller, Andreas Nandy, Christian Radauer, Sanny K Chan, Uta Jappe, Jörg Kleine-Tebbe, Wayne R Thomas, Martin D Chapman, Marianne van Hage, Ronald van Ree, Stefan Vieths, Monika Raulf, Richard E Goodman
A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994...
August 2018: Molecular Immunology
Carla C Baan
Developments in organ preservation techniques, novel immunosuppressants and improved diagnostics have made organ transplantation the success it is today. That does not mean that we are not still striving to perfect techniques, or that there are no more problems to solve. New strategies to address the donor organ shortage, prevent and manage antibody-mediated rejection, lower long-term allograft failure rates and reduce the toxicity of lifelong immunosuppressive medication are urgently needed, and are being widely researched...
June 2018: Transplantation
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