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https://www.readbyqxmd.com/read/30418423/an-easy-and-sensitive-method-to-profile-the-antibody-specificities-of-hla-specific-memory-b-cells
#1
Gonca E Karahan, Juliette Krop, Caroline Wehmeier, Yvonne de Vaal, Janneke Langerak-Langerak, Dave L Roelen, Neubury M Lardy, Frederike J Bemelman, Ineke Ten Berge, Marlies E J Reinders, Cees van Kooten, Frans H J Claas, Sebastiaan Heidt
BACKGROUND: Pre-transplant immunological risk assessment is currently based on donor-specific HLA antibodies in serum. Despite being an excellent source for antibodies produced by bone marrow-residing plasma cells, serum analysis does not provide information on the memory B cell compartment. While B cell culture supernatants can be used to detect memory B cell derived HLA antibodies, low IgG concentrations can preclude detectability of HLA antibodies in luminex single antigen bead (SAB) assays...
November 9, 2018: Transplantation
https://www.readbyqxmd.com/read/30372820/gene-therapy-and-type-1-diabetes-mellitus
#2
REVIEW
Dinesh Kumar Chellappan, Nandhini S Sivam, Kai Xiang Teoh, Wai Pan Leong, Tai Zhen Fui, Kien Chooi, Nico Khoo, Fam Jia Yi, Jestin Chellian, Lim Lay Cheng, Rajiv Dahiya, Gaurav Gupta, Gautam Singhvi, Srinivas Nammi, Philip Michael Hansbro, Kamal Dua
BACKGROUND: Type 1 diabetes mellitus (T1DM) is an autoimmune disorder characterized by T cell-mediated self-destruction of insulin-secreting islet β cells. Management of T1DM is challenging and complicated especially with conventional medications. Gene therapy has emerged as one of the potential therapeutic alternatives to treat T1DM. This review primarily focuses on the current status and the future perspectives of gene therapy in the management of T1DM. A vast number of the studies which are reported on gene therapy for the management of T1DM are done in animal models and in preclinical studies...
October 1, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/30348263/the-influenza-chronicles-from-the-1918-pandemic-to-current-understanding-of-host-defense-mechanisms
#3
EDITORIAL
Emma Louise Walton
In this special edition of the Biomedical Journal, we learn about the battle between host and influenza virus at the respiratory epithelium, and how the history of influenza pandemics has driven both major advances in the understanding of immunology and planning for future outbreaks. We also learn of a nanoparticle system that holds promise for photodynamic therapy in breast cancer. Finally, we add evidence to the debate of the safety of a minimally invasive technique for aortic valve replacement in elderly patients...
August 2018: Biomedical Journal
https://www.readbyqxmd.com/read/30344169/nutritional-impact-on-immunological-maturation-during-childhood-in-relation-to-the-environment-nice-a-prospective-birth-cohort-in-northern-sweden
#4
Malin Barman, Fiona Murray, Angelina I Bernardi, Karin Broberg, Sven Bölte, Bill Hesselmar, Bo Jacobsson, Karin Jonsson, Maria Kippler, Hardis Rabe, Alastair B Ross, Fei Sjöberg, Nicklas Strömberg, Marie Vahter, Agnes E Wold, Ann-Sofie Sandberg, Anna Sandin
INTRODUCTION: Prenatal and neonatal environmental factors, such as nutrition, microbes and toxicants, may affect health throughout life. Many diseases, such as allergy and impaired child development, may be programmed already in utero or during early infancy. Birth cohorts are important tools to study associations between early life exposure and disease risk. Here, we describe the study protocol of the prospective birth cohort, 'Nutritional impact on Immunological maturation during Childhood in relation to the Environment' (NICE)...
October 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/30332560/type-i-interferons-in-autoimmune-disease
#5
Mary K Crow, Mikhail Olferiev, Kyriakos A Kirou
Type I interferons, which make up the first cytokine family to be described and are the essential mediators of antivirus host defense, have emerged as central elements in the immunopathology of systemic autoimmune diseases, with systemic lupus erythematosus as the prototype. Lessons from investigation of interferon regulation following virus infection can be applied to lupus, with the conclusion that sustained production of type I interferon shifts nearly all components of the immune system toward pathologic functions that result in tissue damage and disease...
October 17, 2018: Annual Review of Pathology
https://www.readbyqxmd.com/read/30327837/building-the-prestige-of-archivum-immunologiae-et-therapiae-experimentalis-from-a-little-known-to-an-internationally-recognized-journal
#6
EDITORIAL
Hubert Krotkiewski, Andrzej Górski, Michał Zimecki
Archivum Immunologiae et Therapiae Experimentalis (AITE) was founded in 1953 by Ludwik Hirszfeld, a world famous Polish physician and scientist in the field of microbiology and immunology. Initially, AITE was published in Polish, but within a few years, it changed to English to increase the range and number of international readers. In its over 65 year history, AITE has had several Editors and a number of Publishers. In the period 1977-1991, AITE was listed in the system of scientific information Current Contents/Life Sciences, but for several years, its impact on the international readership of the Journal was negligible...
October 16, 2018: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/30315571/the-100-top-cited-publications-in-psoriatic-arthritis-a-bibliometric-analysis
#7
REVIEW
Adam Berlinberg, Jawad Bilal, Irbaz B Riaz, Drew J B Kurtzman
BACKGROUND: Citation analysis is a quantitative, bibliometric method that analyzes the frequency and pattern of citations in any given scientific discipline. Over the last two decades, the study of psoriatic arthritis has undergone substantial progress, which has enhanced our ability to assess and treat the disease, and yet an updated citation analysis that reflects these advances is lacking. OBJECTIVE: To highlight the scientific progress in psoriatic arthritis by identifying and analyzing the 100 top-cited psoriatic arthritis articles from the last 40 years...
October 12, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/30285462/hepatitis-e-virus-animal-models-and-zoonosis
#8
Scott P Kenney, Xiang-Jin Meng
Hepatitis E virus (HEV) is an important human pathogen that historically has been difficult to study. Limited levels of replication in vitro hindered our understanding of the viral life cycle. Sporadic and low-level virus shedding, lack of standardized detection methods, and subclinical infections made the development of animal models difficult. Better diagnostic techniques and understanding of the virus increased our ability to identify and characterize animal strains and animals that are amenable to model human-relevant infection...
October 4, 2018: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/30276869/highlights-and-recent-developments-in-food-and-drug-allergy-and-anaphylaxis-in-eaaci-journals-2017
#9
REVIEW
P A Eigenmann, C Akdis, J Bousquet, C Grattan, K Hoffmann-Sommergruber, P W Hellings, I Agache
This review highlights research advances and important achievements in food allergy, anaphylaxis and drug allergy that were published in the Journals of the European Academy of Allergy and Clinical Immunology (EAACI) in 2017. Food allergy and anaphylaxis research have continued to rapidly accelerate, with increasing numbers of outstanding developments in 2017. We saw new studies on the mechanisms, diagnosis, prevention of food allergy and novel food allergens. Drug hypersensitivity, as well as hereditory angioedema, have been highlighted in the present review as the focus of recent developments...
October 1, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/30246874/vitamin-d-for-the-management-of-multiple-sclerosis
#10
REVIEW
Vanitha A Jagannath, Graziella Filippini, Carlo Di Pietrantonj, G V Asokan, Edward W Robak, Liz Whamond, Sarah A Robinson
BACKGROUND: This review is an update of a previously published review, "Vitamin D for the management of multiple sclerosis" (published in the Cochrane Library; 2010, Issue 12). Multiple sclerosis (MS) is characterised by inflammation, demyelination, axonal or neuronal loss, and astrocytic gliosis in the central nervous system (CNS), which can result in varying levels of disability. Some studies have provided evidence showing an association of MS with low levels of vitamin D and benefit derived from its supplementation...
September 24, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30234197/datapackager-reproducible-data-preprocessing-standardization-and-sharing-using-r-bioconductor-for-collaborative-data-analysis
#11
Greg Finak, Bryan Mayer, William Fulp, Paul Obrecht, Alicia Sato, Eva Chung, Drienna Holman, Raphael Gottardo
A central tenet of reproducible research is that scientific results are published along with the underlying data and software code necessary to reproduce and verify the findings. A host of tools and software have been released that facilitate such work-flows and scientific journals have increasingly demanded that code and primary data be made available with publications. There has been little practical advice on implementing reproducible research work-flows for large 'omics' or systems biology data sets used by teams of analysts working in collaboration...
July 10, 2018: Gates open research
https://www.readbyqxmd.com/read/30226648/dear-readers-of-the-scandinavian-journal-of-immunology-and-eci-2018-attendees
#12
EDITORIAL
Petter Höglund
No abstract text is available yet for this article.
September 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/30199145/a-fresh-new-look-and-a-fresh-new-journal
#13
EDITORIAL
Rick Bucala, Marian Hannan
The founding of Arthritis & Rheumatism by the American Rheumatism Association in 1958 occurred at the advent of knowledge of immunologic abnormalities in patients with rheumatoid arthritis, SLE, and related disorders. Over its ensuing 60 year history, "A&R" (renamed to Arthritis & Rheumatology in 2014) developed into a preeminent publication for disseminating research findings and advancing the field scientifically. Landmark papers included the role of autoantibodies and lymphocytes in rheumatic diseases and, in recent years, the clinical translation of cell and cytokine-based paradigms of disease...
September 10, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/30183507/immunological-basis-for-recurrent-fetal-loss-and-pregnancy-complications
#14
Hitesh Deshmukh, Sing Sing Way
Pregnancy stimulates an elaborate assortment of dynamic changes, allowing intimate approximation of genetically discordant maternal and fetal tissues. Although the cellular and molecular details about how this works remain largely undefined, important clues arise from evaluating how a prior pregnancy influences the outcome of a future pregnancy. The risk of complications is consistently increased when complications occurred in a prior pregnancy. Reciprocally, a prior successful pregnancy protects against complications in a future pregnancy...
September 5, 2018: Annual Review of Pathology
https://www.readbyqxmd.com/read/30178531/ilc2-at-home-in-the-thymus
#15
Tom Cupedo
The relevance of innate lymphoid cells (ILC) for anti-infectious immunity remains a matter of constant debate. At the same time, evidence for additional, non-immune related functions of ILC is steadily increasing. In the thymus, non-immune functions of ILC were shown for group 3 ILC (ILC3), which regulate differentiation and proliferation of thymic epithelial cells. In this issue of the European Journal of Immunology, Withers and colleagues [Eur. J. Immunol. 2018. 48: 1481-1491] now show that ILC2, a subset of ILCs specialized in tissue protection and regeneration, are the major ILC subset in the adult thymus, heavily outnumbering ILC3...
September 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/30153121/patient-self-reported-adherence-to-ritonavir-boosted-darunavir-combined-with-either-raltegravir-or-tenofovir-disoproxil-fumarate-emtricitabine-in-the-neat-001-anrs-143-trial
#16
Adriana Ammassari, Wolfgang Stöhr, Andrea Antinori, Jean-Michel Molina, Christine Schwimmer, Pere Domingo, Anders Thalme, Massimo Di Pietro, Cedrick Wallet, Anton Pozniak, Laura Richert, François Raffi
BACKGROUND: The NEAT 001/ANRS 143 trial demonstrated non-inferiority of darunavir-ritonavir combined with either raltegravir (RAL+DRV/r) or tenofovir disoproxil fumarate/emtricitabine (TDF/FTC+DRV/r) in HIV-positive, antiretroviral-naive adults. In post-hoc analyses however, RAL+DRV/r showed inferiority in patients with baseline CD4+ <200/mm and HIV-1 RNA ≥100,000 copies/mL. This pre-planned ancillary study was conducted to assess whether differences in adherence might explain efficacy results SETTING:: Phase III, open-label, randomized, multicentre study in 15 European countries (ClinicalTrials...
August 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/30147199/identifying-hot-papers-and-papers-with-delayed-recognition-in-large-scale-datasets-by-using-dynamically-normalized-citation-impact-scores
#17
Lutz Bornmann, Adam Y Ye, Fred Y Ye
"Hot papers" (HPs) are papers which received a boost of citations shortly after publication. Papers with "delayed recognition" (DRs) received scarcely impact over a long time period, before a considerable citation boost started. DRs have attracted a lot of attention in scientometrics and beyond. Based on a comprehensive dataset with more than 5,000,000 papers published between 1980 and 1990, we identified HPs and DRs. In contrast to many other studies on DRs, which are based on raw citation counts, we calculated dynamically field-normalized impact scores for the search of HPs and DRs...
2018: Scientometrics
https://www.readbyqxmd.com/read/30144595/the-impact-of-specialization-in-journal-networks-and-scholarship
#18
Michael Karsy, Mohammed A Azab, Jian Guan, William T Couldwell, John D Rolston
BACKGROUND: The use of bibliometrics to evaluate authors, institutions, and journals faces significant challenges in comparing biomedical specialties because of marked differences among fields. Our objective was to evaluate the effect of specialty field and physician numbers on bibliometric parameters. METHODS: For this bibliometric analysis, data from MDLinx.com and SCImago Journal & Country Rank for 2016 were used to rank the journals. The 2015 Physician Specialty Data Report provided the number of specialists in specific fields...
August 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30133745/paths-to-expansion-differential-requirements-of-irf4-in-cd8-t-cell-expansion-driven-by-antigen-and-homeostatic-cytokines
#19
Enrico Lugli, Jolanda Brummelman, Karolina Pilipow, Rahul Roychoudhuri
Interferon regulatory factor 4 (IRF4) regulates the clonal expansion and metabolic activity of activated T cells, but the precise context and mechanisms of its function in these processes are unclear. In this issue of the European Journal of Immunology, Miyakoda et al. [Eur. J. Immunol. 2018. 48: 1319-1328] show that IRF4 is required for activation and expansion of naïve and memory CD8+ T cells driven by T-cell receptor (TCR) signaling, but dispensable for memory CD8+ T-cell maintenance and homeostatic proliferation driven by homeostatic cytokines...
August 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/30082356/complementary-vaccination-protocol-with-dendritic-cells-pulsed-with-autologous-tumour-lysate-in-patients-with-resected-stage-iii-or-iv-melanoma-protocol-for-a-phase-ii-randomised-trial-acdc-adjuvant-trial
#20
Laura Ridolfi, Francesco de Rosa, Laura Fiammenghi, Massimiliano Petrini, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Jenny Bulgarelli, Angela Riccobon, Giorgia Gentili, Oriana Nanni, Massimo Framarini, Francesca Tauceri, Massimo Guidoboni
INTRODUCTION: Surgery is one of the treatments of choice for patients with a single metastasis from melanoma but is rarely curative. Such patients could potentially benefit from consolidation immunotherapy. Vaccination with dendritic cells (DCs) loaded with tumour antigens elicits a tumour-specific immune response. In our experience, patients who developed delayed type hypersensitivity (DTH) after DC vaccination showed a median overall survival (OS) of 22.9 monthsvs4.8 months for DTH-negative cases...
August 5, 2018: BMJ Open
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