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Na+K+ATPase

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https://www.readbyqxmd.com/read/30005306/blood-brain-barrier-breakdown-memory-impairment-and-neurotoxicity-caused-in-mice-submitted-to-orally-treatment-with-thymol
#1
Matheus D Baldissera, Carine F Souza, Antônio Francisco Igor M De Matos, Pedro Henrique Doleski, Bernardo Baldisserotto, Aleksandro S Da Silva, Silvia G Monteiro
Several evidences have related the biochemical and pharmacological properties of thymol, but the possible neurotoxic effects of this compound remain unknown and not evaluated. Thus, the purpose of this study was to evaluate whether intake of thymol in different doses (10, 20 and 40 mg/kg) induce neurotoxicity and behavioral alterations using mice as experimental model, as well as the involvement of blood-brain barrier (BBB) and brain neurotransmitters in these alterations. Thymol (20 and 40 mg/kg) significantly decrease latency time to inhibitory avoidance task when compared to control group, indicating a memory loss after 30 days of oral treatment...
July 8, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/30002998/plants-in-traditional-medicine-with-special-reference-to-cyperus-rotundus-l-a-review
#2
REVIEW
Arunagiri Kamala, Sushil Kumar Middha, Chandrakant S Karigar
The nutgrass, Cyperus rotundus L. (Family: Cyperaceae), is a colonial, perennial herb considered to have originated in India 2000 years ago and widely used in Ayurveda to treat several ailments. In addition to its prehistoric uses, it is used in several systems of medicine for treating variety of diseases. The synergistic actions of the Cyperus ' compounds have added advantage over that of a single constituent. In the past decade, numerous studies proved analgesic, anti-allergic, anti-arthritic, anti-candida, anti-cariogenic, anti-convulsant, anti-diarrheal, anti-emetic, anti-helminthic, anti-histamine, anti-hyperglycemic, anti-hypertensive, anti-inflammatory, anti-malarial, anti-obesity, antioxidant, anti-platelet, anti-pyretic, anti-ulcer, anti-viral, cardioprotective, cytoprotective, cytotoxic, gastroprotective, hepatoprotective, neuroprotective, ovicidal, and larvicidal, wound healing and inhibition of brain Na+ K+ ATPase activities of C...
July 2018: 3 Biotech
https://www.readbyqxmd.com/read/30001601/attenuation-of-na-k-atpase-src-ros-amplification-signal-pathway-with-pnaktide-ameliorates-myocardial-ischemia-reperfusion-injury
#3
Hua Li, Anwen Yin, Zijie Cheng, Mengwen Feng, Hao Zhang, Jia Xu, Fei Wang, Lingmei Qian
OBJECTIVES: Oxidative stress plays an important role in myocardial ischemia-reperfusion (I/R) injury. And pNaKtide is known to inhibit Na/K-ATPase/Src/reactive oxygen species (ROS) amplification signaling. Accordingly, we aimed to investigate the effect of pNaKtide on myocardial I/R injury. METHODS: We first determine the effect of pNaKtide on hypoxia- or cobalt chloride-induced injury in embryonic heart-derived H9c2 cells via measuring lactate dehydrogenase (LDH) level and trypan blue stain assay...
July 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29985831/low-molecular-weight-chondroitin-sulfate-attenuated-injury-by-inhibiting-oxidative-stress-in-amyloid-%C3%AE-treated-sh-sy5y-cells
#4
Qian Zhang, Zhao Na, Yanna Cheng, Fengshan Wang
The neurotoxicity of aggregated amyloid β (Aβ) has been implicated as a critical cause in the pathogenesis of Alzheimer's disease. In a previous work, we have shown that low-molecular-weight chondroitin sulfate (LMWCS), a derivative of chondroitin sulfate, protected the SH-SY5Y neuroblastoma cells from Aβ25-35-induced neurotoxicity, decreased intracellular reactive oxygen species level and inhibited the cell apoptosis. However, the underlying mechanism of the antioxidative effect of LMWCS in the SH-SY5Y cells has not been well explored...
July 6, 2018: Neuroreport
https://www.readbyqxmd.com/read/29985440/cancer-mortality-does-not-differ-by-antiarrhythmic-drug-use-a-population-based-cohort-of-finnish-men
#5
Kalle J Kaapu, Lauri Rantaniemi, Kirsi Talala, Kimmo Taari, Teuvo L J Tammela, Anssi Auvinen, Teemu J Murtola
In-vitro studies have suggested that the antiarrhythmic drug digoxin might restrain the growth of cancer cells by inhibiting Na+/K+-ATPase. We evaluated the association between cancer mortality and digoxin, sotalol and general antiarrhythmic drug use in a retrospective cohort study. The study population consists of 78,615 men originally identified for the Finnish Randomized Study of Screening for Prostate Cancer. Information on antiarrhythmic drug purchases was collected from the national prescription database...
July 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29978878/interaction-of-au-iii-and-pt-ii-complexes-with-na-k-atpase-experimental-and-theoretical-study-of-reaction-stoichiometry-and-binding-sites
#6
Ana V Vujačić Nikezić, Goran V Janjić, Aleksandra M BondŽić, BoŽidarka L Zarić, Dragana D Vasić-Anićijević, Tatjana G Momić, Vesna M Vasić
The present paper deals with investigation of the interaction between selected simple structure Au(iii) ([AuCl4]-, [AuCl2(dmso)2]+, [AuCl2(bipy)]+) and Pt(ii) ([PtCl2(dmso)2]) complexes with Na/K-ATPase as the target enzyme, using an experimental and theoretical approach. Reaction stoichiometries and binding constants for these enzyme/complex systems were determined, while kinetic measurements were used in order to reveal the type of inhibition. Based on the results obtained by quantum mechanical calculations (electrostatic surface potential (ESP), volume and surface of the complexes) the nature of the investigated complexes was characterized...
July 6, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29978351/oxidative-stress-mediated-the-inhibition-of-cerebral-creatine-kinase-activity-in-silver-catfish-fed-with-aflatoxin-b-1-contaminated-diet
#7
Carine F Souza, Matheus D Baldissera, Carla C Zeppenfeld, Sharine Descovi, Lenita M Stefani, Bernardo Baldisserotto, Aleksandro S da Silva
Aflatoxin B1 (AFB1 ) is an environmental toxicant and neurotoxic compound that induces the production of free radicals, causing oxidative stress. Creatine kinase (CK) is a central controller of energy metabolism in tissues with a large and fluctuating energy demand, and it is highly susceptible to inactivation by free radicals and oxidative damage. Thus, the aim of this study was to evaluate whether a diet for freshwater silver catfish (Rhamdia quelen) containing AFB1 inhibits cerebral CK activity, as well as the involvement of the oxidative stress on this inhibition...
July 6, 2018: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29970705/evaluation-of-the-relationship-of-erythrocyte-membrane-na-k-atpase-enzyme-activity-and-tumor-response-to-chemoradiotherapy-in-patients-diagnosed-with-locally-advanced-nonsmall-cell-lung-cancer-and-glioblastoma-multiforme
#8
Cigdem Damla Cetinkaya, Mehmet Gurbilek, Mehmet Koc
Context: Radiotherapy is the commonly used therapeutic modality for inoperable cancer types. We investigated chemoradiotherapy (CRT) effects on the Na + /K + -ATPase enzyme. Aims: The aim of the present study was to determine the usefulness of Na + /K + -ATPase enzyme as a prognostic factor and as a potential target for increasing the CRT response of nonsmall cell lung cancer (NSCLC) and glioblastoma multiforme (GBM). Settings and Design: We prospectively evaluated 30 patients (all were treated with CRT) and 20 healthy controls...
June 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29962265/induction-of-a-na-k-atpase-dependent-form-of-autophagy-triggers-preferential-cell-death-of-human-immunodeficiency-virus-type-1-infected-macrophages
#9
Gang Zhang, Brian T Luk, Morcel Hamidy, Liangfang Zhang, Stephen A Spector
Although antiretroviral therapy is highly effective in suppressing human immunodeficiency virus type-1 (HIV) replication, treatment has failed to eliminate viral reservoirs and discontinuation of treatment results in viral reactivation. Here, we demonstrate that peptides Tat-vFLIP-α2 and Tat-Beclin 1/BECN1 which have been shown to induce a Na+ /K+ -ATPase- and a macroautophagy/autophagy-dependent form of cell death, autosis, can preferentially kill HIV-infected macrophages while preventing virological rebound...
July 2, 2018: Autophagy
https://www.readbyqxmd.com/read/29956732/single-walled-carbon-nanohorn-aggregates-promotes-mitochondrial-dysfunction-induced-apoptosis-in-hepatoblastoma-cells-by-targeting-sirt3
#10
Bowei Li, Xiaoxun Chen, Wenbin Yang, Jingliang He, Ke He, Zhenglin Xia, Jinqian Zhang, Guoan Xiang
Single-walled carbon nanohorns (SWNHs) can accumulate in a variety of cell types or tissues and exert biological effects, which have been demonstrated to induce apoptosis in hepatoblastoma cells. However, the role and molecular mechanisms of SWNHs remain unclear. The mitochondrion is an important subcellular structure and may contribute to apoptosis that is induced by SWNHs in hepatoblastoma cells. To address this question, the mitochondrial function of HepG2 or L02 cells that were treated with SWNHs was examined...
June 28, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29956316/effects-of-elevated-temperature-on-osmoregulation-and-stress-responses-in-atlantic-salmon-salmo-salar-smolts-in-freshwater-and-seawater
#11
L Vargas-Chacoff, A M Regish, A Weinstock, S D McCormick
Smolting in Atlantic salmon Salmo salar is a critical life-history stage that is preparatory for downstream migration and entry to seawater that is regulated by abiotic variables including photoperiod and temperature. The present study was undertaken to determine the interaction of temperature and salinity on salinity tolerance, gill osmoregulatory proteins and cellular and endocrine stress in S. salar smolts. Fish were exposed to rapid changes in temperature (from 14 to 17, 20 and 24° C) in fresh water (FW) and seawater (SW), with and without prior acclimation and sampled after 2 and 8 days...
June 28, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29954175/chronic-heat-stress-damages-small-intestinal-epithelium-associated-with-ampk-pathway-in-broilers
#12
He Xiaofang, Zhuang Lu, Bingbing Ma, Lin Zhang, Jiaolong Li, Yun Jiang, Guanghong Zhou, Feng Gao
Heat-stressed broilers usually reduce their feed intake, leading to energy imbalance and disturbing the homeostasis in the intestinal tract. The study was aimed to understand heat stress-mediated physiological events that may contribute to impairments in intestinal tract of broilers. The results showed that heat exposure increased the activities of trypsin and Na+/K+-ATPase, while decreased the activities of amylase, lipase and maltase, as well as the proliferating cell nuclear antigen cells in the jejunum after 14 days of heat exposure...
June 28, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29953424/ouabain-protects-mice-against-lipopolysaccharide-induced-acute-lung-injury
#13
Changli Wang, Yan Meng, Yuanyuan Wang, Zhengyu Jiang, Mengda Xu, Lulong Bo, Xiaoming Deng
BACKGROUND Ouabain, an inhibitor of Na+/K+-ATPase, is a type of endogenous hormone synthesized in the adrenal cortex and hypothalamus. Previous studies found that ouabain potently inhibited inflammatory reactions and regulated immunological processes. Our present study aimed to investigate the therapeutic role of ouabain on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. MATERIAL AND METHODS Ouabain (0.1 mg/kg) or vehicles were intraperitoneally injected into male C57BL/6J mice once a day for 3 consecutive days...
June 28, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29948908/gill-morphology-and-na-k-atpase-activity-of-gobionellus-oceanicus-teleostei-gobiidae-in-an-estuarine-system
#14
Helena Rachel da Mota Araujo, Marisa Narciso Fernandes, André Luis da Cruz
Gobionellus oceanicus is a species widely distributed on the Atlantic coast and may be susceptible to anthropic effects. This study evaluated the morphology and the Na+ /K+ -ATPase activity of G. oceanicus gills considering the concentration of metals in the fish and Subaé River estuary. Although the metal concentrations detected in the water and sediment did not exceed certain limits, CONAMA (Brazilian Environment Council), TEL (Threshold Effect Level), and PEL (Probable Effect Level), the metals levels in gills plus muscle and skin of G...
June 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29948664/physiological-and-biochemical-characteristics-of-skeletal-muscles-in-sedentary-and-active-rats
#15
Hongyang Xu, Xiaoyu Ren, Graham D Lamb, Robyn M Murphy
Laboratory rats are sedentary if housed in conditions where activity is limited. Changes in muscle characteristics with chronic inactivity were investigated by comparing sedentary rats with rats undertaking voluntary wheel running for either 6 or 12 weeks. EDL (type II fibers) and soleus (SOL) muscles (predominantly type I fibers) were examined. When measured within 1-2 h post-running, calcium sensitivity of the contractile apparatus was increased, but only in type II fibers. This increase disappeared when fibers were treated with DTT, indicative of oxidative regulation of the contractile apparatus, and was absent in fibers from rats that had ceased running 24 h prior to experiments...
June 15, 2018: Journal of Muscle Research and Cell Motility
https://www.readbyqxmd.com/read/29946188/sodium-orthovanadate-overcomes-sorafenib-resistance-of-hepatocellular-carcinoma-cells-by-inhibiting-na-k-atpase-activity-and-hypoxia-inducible-pathways
#16
Wenjing Jiang, Guangxin Li, Weidong Li, Ping Wang, Peng Xiu, Xian Jiang, Bing Liu, Xueying Sun, Hongchi Jiang
The resistance to sorafenib highly affects its clinical benefits for treating hepatocellular carcinoma (HCC). Sodium orthovanadate (SOV) is a phosphate analog that displays anti-cancer activities against various types of malignancies including HCC. The present study has demonstrated that SOV is able to overcome sorafenib resistance and strengthens sorafenib in suppressing sorafenib-resistant HCC cells in vitro and in animal models. Similar to its action on parental HCC cells, SOV induced cell cycle arrest at G2/M phases by regulating cyclin B1 and cyclin-dependent kinase 1, and apoptosis by reducing mitochondrial membrane potential, in sorafenib-resistant HCC cells...
June 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29946187/the-na-k-atpase-oxidant-amplification-loop-regulates-aging
#17
Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L Klug, Jiang Liu, Xiaoliang Wang, Krithika Srikanthan, Perrine Goguet-Rubio, Athar Nawab, Rebecca Pratt, Megan N Lilly, Juan R Sanabria, Zijian Xie, Nader G Abraham, Joseph I Shapiro
As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 old mice were given a western diet to stimulate oxidant injury or pNaKtide to antagonize the NKAL. The western diet accelerated functional and morphological evidence for aging whereas pNaKtide attenuated these changes. Next, human dermal fibroblasts (HDFs) were exposed to different types of oxidant stress in vitro each of which increased expression of senescence markers, cell-injury, and apoptosis as well as stimulated the NKAL...
June 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29945380/-vinegar-processing-attenuates-toxicity-on-iec-6-cells-caused-by-chloroform-extraction-of-daphne-genkwa
#18
Qin-Rong Zhou, Lin-Yan Xiao, Qi-Nan Liu, Pan-Pan Sun, Li Zhang
To screen the toxic polar fractions of Daphne genkwa, compare the toxicity of D. genkwa on crypts epithelial cells IEC-6 before and after vinegar processing, and preliminarily investigate the mechanism of D. genkwa vinegar processing on toxicity reducing. The proliferation of IEC-6 cells was observed by MTT. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), lactate dehydrogenase (LDH), as well as the enzyme activity of Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase were determined in IEC-6 cells to evaluate the oxidative damages degree of IEC-6 cells...
June 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29943667/rapamycin-confers-neuroprotection-against-aging-induced-oxidative-stress-mitochondrial-dysfunction-and-neurodegeneration-in-old-rats-via-activation-of-autophagy
#19
Abhishek Kumar Singh, Sandeep Singh, Vinay Kumar Tripathi, Akalabya Bissoyi, Geetika Garg, Syed Ibrahim Rizvi
Brain aging is an intricate and natural phenomenon exclusively characterized by oxidative stress, accumulation of oxidatively damaged macromolecules, and alterations in structure and function of neurons that further increase the risk factor for most of the neurodegenerative diseases. In addition, age-dependent defective autophagy has also been implicated to favour the pathogenesis and prevalence of the neurological diseases. Therefore, the development of strategies that delay aging and the concomitant neurological disorders remain elusive...
June 26, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29940574/generation-and-role-of-oscillatory-contractions-in-mouse-airway-smooth-muscle
#20
Hao Xu, Ping Zhao, Wen-Jing Zhang, Jun-Ying Qiu, Li Tan, Xiao-Cao Liu, Qian Wang, Xi Luo, Yu-Shan She, Dun-An Zang, Bei-Bei Liu, Lei Cao, Xiao-Xue Zhao, Yuan-Yuan Chen, Meng-Yue Li, Jinhua Shen, Yong-Bo Peng, Lu Xue, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Gangjian Qin, Qing-Hua Liu
BACKGROUND/AIMS: Tetraethylammonium chloride (TEA) induces oscillatory contractions in mouse airway smooth muscle (ASM); however, the generation and maintenance of oscillatory contractions and their role in ASM are unclear. METHODS: In this study, oscillations of ASM contraction and intracellular Ca2+ were measured using force measuring and Ca2+ imaging technique, respectively. TEA, nifedipine, niflumic acid, acetylcholine chloride, lithium chloride, KB-R7943, ouabain, 2-Aminoethoxydiphenyl borate, thapsigargin, tetrodotoxin, and ryanodine were used to assess the mechanism of oscillatory contractions...
June 21, 2018: Cellular Physiology and Biochemistry
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