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metanephric adenoma

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https://www.readbyqxmd.com/read/27784295/the-findings-of-ct-and-mri-in-patients-with-metanephric-adenoma
#1
Jing Yan, Jing-Liang Cheng, Chen-Fei Li, Yan-Bang Lian, Yuan Zheng, Xue-Ping Zhang, Chao-Yan Wang
BACKGROUND: Metanephric adenoma (MA) is a benign renal tumor that is difficult to distinguish from a malignant tumor via traditional radiography. The diagnosis of MA is often dependent on postsurgical histopathological examination. In the present report, the imaging features of MA on computer tomography (CT) and magnetic resonance imaging (MRI) were retrospectively evaluated. METHODS: Eight MA patients, 17-67 years of age, were pathologically confirmed and recruited between April 2009 and November 2014...
October 27, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27769870/braf-exon-15-mutations-in-pediatric-renal-stromal-tumors-prevalence-in-metanephric-stromal-tumors
#2
Lily Marsden, Lawrence J Jennings, Samantha Gadd, Min Yu, Elizabeth J Perlman, Mariana M Cajaiba
Metanephric stromal tumors are rare renal stromal tumors that predominantly affect children. They belong to the metanephric family of tumors along with metanephric adenofibroma and metanephric adenoma. The previous documentation of BRAF exon 15 mutations in 88% of metanephric adenomas and in isolated cases of metanephric adenofibroma prompted us to investigate the prevalence of these mutations in metanephric stromal tumors and in other pediatric renal stromal tumors. In this study, 17 metanephric stromal tumors, 22 congenital mesoblastic nephromas and 6 ossifying renal tumors of infancy were selected for BRAF exon 15 testing...
October 18, 2016: Human Pathology
https://www.readbyqxmd.com/read/27538135/-clinicopathological-features-and-differential-diagnosis-of-metanephric-adenoma-a-report-of-sixteen-cases
#3
C G Xi, Y Fan, X Y Yang, L B Liu, J H Wang, S Hu, Y Y Li, Q He
OBJECTIVE: To study the clinicopathological features and differential diagnosis of metanephric adenoma (MA). METHODS: The clinicopathological data of 16 cases with MA diagnosed and treated in Peking University First Hospital from 2004 to 2016 were retrospectively analyzed, and the clinical characteristics, pathologic parameters, differential diagnosis, treatment options and prognosis of MA were analyzed with literature review. RESULTS: The patients included 10 females and 6 males...
February 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27517493/distinct-clinicopathological-features-in-metanephric-adenoma-harboring-braf-mutation
#4
Anna Caliò, John N Eble, Ondrej Hes, Guido Martignoni, Saul E Harari, Sean R Williamson, Matteo Brunelli, Adeboye O Osunkoya, Lisha Wang, Eva Comperat, Antonio Lopez-Beltran, Mingsheng Wang, Shaobo Zhang, Kendra L Curless, Kristin M Post, Hsim-Yee Chang, Claudio Luchini, Lee Ann Baldrige, Gregory T MacLennan, Rodolfo Montironi, David J Grignon, Liang Cheng
BRAF mutation recently has been reported in metanephric adenoma. We sought to determine the clinical and morphologic features of BRAF-mutated metanephric adenoma and to correlate BRAF mutation with BRAF V600E immunohistochemical staining results. A series of 48 metanephric adenomas and 15 epithelial-predominant nephroblastomas were analyzed for the occurrence of BRAF mutation (BRAF V600E/V600E complex, BRAF V600D, BRAF V600K and BRAF V600R) using the BRAF RGQ PCR kit (Qiagen). Immunohistochemistry was performed using monoclonal mouse antibodies against p16INK4 and VE1 (Spring Bioscience), recognizing the BRAF V600E mutant protein...
August 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27471365/a-case-of-metanephric-adenoma-and-acute-myocardial-infarction
#5
Ruzicic Dusan, Kovacevic Relja, Mirkovic Marija, Radovanovic Jelena, Krstevska Vesna, Terzic Milijana, Pantelic Vladimir, Matic Irena, Hrncic Dragan
Metanephric adenoma (MA) is a rare neoplasm that acounts for 0.2% of adult renal neoplasms. MAs are typically discover incidentally during detailed examinations for nonspecific symptoms such as abdominal or flank pain, hematuria, fever and palpable abdominal mass. Additionally, polycythemia has occasionally been reported as well. Herein we describe a case of metanephric adenoma which was an incidental finding in the course of a clinical autopsy in a patient with complete AV block and polycythemia. Histologically, the tumor was composed of small and uniform tubular structures reminiscent of renal tubuli, without signs of cellular atypia and pleomorphism...
July 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27430690/-expression-of-cadherin17-in-metanephric-adenoma-and-its-value-in-differential-diagnosis
#6
X Wang, N Wu, W R Yang, S S Shi, H H Ma, X Wei, X J Zhou, Q Rao
OBJECTIVE: To study the expression of cadherin17(CDH17) in metanephric adenoma (MA), and to explore the value of CDH17 in the diagnosis of metanephric adenoma. METHODS: Immunohistochemical EnVision method was used to detect the expression of CDH17, WT1, CD57, P504S and EMA in 21 cases of MAs, 16 epithelial-predominant Wilms tumors (e-WT), and 20 solid variant of papillary renal cell carcinomas (s-PRCC). The expression of CDH17 was also examined in other common renal epithelial tumors, including 10 cases of clear cell renal cell carcinomas (CCRCC), 10 chromophobe renal cell carcinomas (CHRCC), and 10 oncocytomas...
July 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27398273/retroperitoneal-laparoscopic-partial-nephrectomy-for-treatment-of-metanephric-adenoma-report-of-6-cases
#7
Ju Guo, Xiaochen Zhou, Bin Fu, Runfu Cao, Weipeng Liu, Gongxian Wang
OBJECTIVES: To investigate the clinical and pathological features of metanephric adenoma (MA) and the clinical outcome after retroperitoneal laparoscopic nephron-sparing surgery. METHODS: Six out of 183 partial nephrectomies performed during January 2009 to August 2014 were confirmed to be MA confirmed by postoperative pathological study. Perioperative parameters of the six patients were then retrospectively collected, analyzed and compared with current literature, including warm ischemia time (WIT), total operation time, estimated blood loss (EBL), positive surgical margin (PSM), and complications...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27227914/the-clinical-characteristics-of-metanephric-adenoma-a-case-report-and-literature-review
#8
Hua Fan, Qian-Qian Shao, Han-Zhong Li, Yu Xiao, Yu-Shi Zhang
We describe the clinical presentation, diagnosis, treatment, and follow-up data of a 39-year-old woman with asymptomatic right kidney tumor, which was later histopathologically diagnosed as metanephric adenoma (MA). Macroscopically, the tumor had integrity tegument with homogeneous and gray cutting surface. Microscopically, the tumor cells were formed in adenoid or papillary pattern and contained psammoma bodies, without distinctive atypia. Immunohistochemistry results showed they were negative for creatine kinase 7, epithelial membrane antigen, and renal cell carcinoma, and positive for AE1/AE3, vimentin, and Wilms Tumor 1...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27127119/absence-of-canonical-wnt-signaling-in-adult-renal-cell-tumors-of-embryonal-origin
#9
Nina Kaerger Billfeldt, Daniel Banyai, Gyula Kovacs
BACKGROUND/AIM: The canonical β-catenin pathway is involved in the development of Wilms' tumor, but its role in adult renal cell tumors (RCT) of embryonal origin is not yet known. MATERIALS AND METHODS: We sequenced the catenin beta 1 (CTNNB1) gene in papillary RCTs, applied the TOPflash/FOPflash reporter plasmid system on cell lines, and examined the β-catenin protein expression by immunohistochemistry. RESULTS: The absence of mutations in CTNNB1 and low TOPflash/FOPflash ratio in tumor cell lines indicated the absence of active Wingless-type MMTV integration site family (WNT) signaling in RCTs...
May 2016: Anticancer Research
https://www.readbyqxmd.com/read/26870216/a-metanephric-adenoma-of-the-kidney-associated-with-polycythemia-a-case-report
#10
Pengfei Wang, Yuan Tian, Yuehai Xiao, Yang Zhang, F A Sun, Kaifa Tang
Metanephric adenoma (MA) of the kidney is a rare and frequently benign tumor with a favorable prognosis that is often diagnosed following surgical treatment. In the present study, a 54-year-old female patient presented with complaints of intermittent right-flank pain and anterior abdominal pain occurring over 2 years and sporadic gross hematuria occurring over 3 months. Ultrasonography and computerized tomography imaging revealed a neoplasm lesion localized in the right kidney. Successful open approach radical nephrectomy was performed and post-surgical histopathological examination verified the lesion as a MA of the kidney...
January 2016: Oncology Letters
https://www.readbyqxmd.com/read/26622757/metanephric-adenoma-with-diffuse-calcifications-a-case-report
#11
Jingtao Wu, Qingqiang Zhu, Wenrong Zhu, Hongying Zhang
Metanephric adenoma is a rare and benign renal neoplasm originating in the epithelial cells of the kidney. The tumor has a benign course and a characteristic histopathological appearance, typically exhibiting a solid and poorly-demarcated margin with rare cystic components or calcifications. However, it is often difficult to distinguish metanephric adenoma from malignant neoplasms prior to surgical resection. To the best of our knowledge, only one case of metastasis to the lymph nodes has been described in the literature thus far...
September 2015: Oncology Letters
https://www.readbyqxmd.com/read/26508100/prominent-apical-cytoplasmic-bleb-formation-in-metanephric-adenoma-report-of-a-case
#12
Masayuki Shintaku, Kenichiro Maeno
In a case of metanephric adenoma of the kidney, many apical cytoplasmic blebs were found on the luminal surface of tumor cells. The tumor, measuring 15 mm in diameter, was found incidentally in the right kidney of a 40-year-old woman. It consisted of a dense proliferation of cuboidal cells forming small tubules of round or irregular shape. The apical portion of the cytoplasm of tumor cells exhibited club-shaped expansion or dome-like protrusion which was largely occupied by numerous free ribosomes. The neck portion of the protruded apical cytoplasm was constricted, and the apical cytoplasm appeared to have been "pinched-off" and shed into the lumen...
March 2016: Medical Molecular Morphology
https://www.readbyqxmd.com/read/26486745/thyroid-like-follicular-carcinoma-of-the-kidney-one-case-report-and-review-of-the-literature
#13
REVIEW
Rahul Dawane, Alan Grindstaff, Anil V Parwani, Timothy Brock, Wesley M White, Laurentia Nodit
OBJECTIVES: Thyroid-like follicular carcinoma of the kidney continues to confound the practicing pathologist with its close resemblance to the follicular variant of thyroid carcinoma, as well as other benign and malignant entities. Our goal is to expand the knowledge of this rare renal cell carcinoma subtype, which is morphologically similar to follicular carcinoma of the thyroid but lacks expression of characteristic thyroid immunohistochemical markers such as TTF-1 and thyroglobulin...
November 2015: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26261480/immunohistochemical-phenotype-and-molecular-pathological-characteristics-of-metanephric-adenoma
#14
Zhulei Sun, Shihai Kan, Leilei Zhang, Yan Zhang, Hong Jing, Gui Huang, Qichun Yu, Jiang Wu
To assess the clinicopathological, immunohistochemical and molecular features of metanephric adenoma (MA). Clinicopathologic data were obtained for 5 cases of MA with follow-up information. Specimens from these patients were stained by HE and immunohistochemistry for the detection of WT1, vimentin, S-100 protein, CK7, P504s, CD10 and renal cell carcinoma marker (RCC). Fluorescence in situ hybridization (FISH) was performed on 4 tumors. The patients included 1 male and 4 females, aged from 30 to 49 (mean=39) years...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26248896/metanephric-adenoma-the-utility-of-immunohistochemical-and-cytogenetic-analyses-in-differential-diagnosis-including-solid-variant-papillary-renal-cell-carcinoma-and-epithelial-predominant-nephroblastoma
#15
Stephanie N Kinney, John N Eble, Ondrej Hes, Sean R Williamson, David J Grignon, Mingsheng Wang, Shaobo Zhang, Lee Ann Baldrige, Guido Martignoni, Matteo Brunelli, Lisha Wang, Eva Comperat, Rong Fan, Rodolfo Montironi, Gregory T MacLennan, Liang Cheng
Metanephric adenoma is a benign renal neoplasm that overlaps in morphology with the solid variant of papillary renal cell carcinoma and epithelial-predominant nephroblastoma. To aid in resolving this differential diagnosis, we investigated the utility of immunohistochemical and molecular analyses in distinguishing between these entities; the first study, to our knowledge, to use a combined approach in analyzing all three tumors. We analyzed 37 tumors originally diagnosed as metanephric adenomas (2 of which we reclassified as papillary renal cell carcinomas), 13 solid variant papillary renal cell carcinomas, and 20 epithelial-predominant nephroblastomas using a combination of immunohistochemistry and fluorescence in situ hybridization (FISH) assessing for trisomy of chromosomes 7 and 17 and loss of Y...
September 2015: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/26200482/unusual-benign-solid-neoplasms-of-the-kidney-cross-sectional-imaging-findings
#16
Ali Devrim Karaosmanoğlu, Mehmet Ruhi Onur, Ali Shirkhoda, Mustafa Ozmen, Peter F Hahn
Kidney neoplasms are common diseases with varying prognoses depending on the subtype of the tumor. The most common solid lesion of the kidney is renal cell carcinoma, and the treatment is typically surgical removal. With increasing use of cross-sectional imaging in the last two decades, the detection of renal lesions has significantly increased, especially in asymptomatic patients who are scanned for other reasons. In this article, we present the imaging findings of rare solid benign primary kidney neoplasms including renal leiomyoma, reninoma, carcinoid tumor, metanephric adenoma, solitary fibrous tumor of the kidney, lipomatous hemangiopericytoma of the kidney, renal schwannoma, inflammatory myofibroblastic tumor of the kidney, extramedullary hematopoiesis in the kidney, and extranodal renal Rosai-Dorfman disease...
September 2015: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/26142601/laparoscopic-nephron-sparing-surgery-for-metanephric-adenoma-in-children-a-report-of-2-cases
#17
Ender Ozden, Beytullah Yagiz, Fatih Atac, Hasan Cetin, Yakup Bostanci, Yarkin Kamil Yakupoglu, Saban Sarikaya
Metanephric adenoma (MA) is an epithelial benign tumor of the kidney and very rare in children. Here we present 2 cases of MA treated by laparoscopic nephron-sparing surgery in children. To the best of our knowledge, we report the first cases of laparoscopic nephron-sparing surgery for MA in children.
July 2015: Urology
https://www.readbyqxmd.com/read/26014474/braf-mutations-in-pediatric-metanephric-tumors
#18
Rose Chami, Minzhi Yin, Paula Marrano, Chinachote Teerapakpinyo, Shanop Shuangshoti, Paul Scott Thorner
Metanephric neoplasms of the kidney are uncommon, and some cases are associated with papillary carcinoma. Most cases of metanephric adenoma occur in adults, with fewer than 25 cases reported in children, and metanephric adenofibroma is even less common. The few metanephric tumors studied at the genetic level have not shown the gains of chromosomes 7 and 17 commonly seen in renal cell carcinoma, suggesting that the carcinoma arising in this setting has a separate genetic origin from the adenoma. However, the assumption that this carcinoma has the same chromosome gains as sporadic renal cell carcinoma has never been validated...
August 2015: Human Pathology
https://www.readbyqxmd.com/read/25966289/ct-imaging-spectrum-and-the-histopathological-features-of-adult-metanephric-adenoma
#19
G Li, F Fu, H Song, Y Niu, Y Su
OBJECTIVE: To retrospectively evaluate the radiopathological features of adult metanephric adenoma (MA) and explore whether MA can be differentiated on CT images, including the basis of their morphological features and enhancement patterns. METHODS: 18 consecutive MA cases (age range, 18-66 years; 9 males and 9 females) were pathologically proven and recruited in our study between January 2004 and June 2014. Unenhanced and contrast-enhanced CT were performed and correlated with corresponding pathological findings to differentiate between MA and other renal tumours...
July 2015: British Journal of Radiology
https://www.readbyqxmd.com/read/25918196/cytologic-features-of-metanephric-adenoma-of-the-kidney-case-report-and-review-of-the-literature
#20
REVIEW
Jinous Saremian, Melanie J Kubik, Shahla Masood
Metanephric adenoma (MA) is a rare, benign renal tumor that can be found in individuals of any age. The histological features of this lesion are well known; however, cytological features of this entity have rarely been described. Herein, we present the case of a 37-year-old white woman with multiple endocrine dysfunctions and a renal mass. The diagnosis of metanephric adenoma was suggested as a differential diagnosis during imprint cytology; this diagnosis was later confirmed by core needle biopsy (CNB) and the results of immunostaining...
2015: Laboratory Medicine
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