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https://www.readbyqxmd.com/read/29680851/lichenoid-lesions-of-the-upper-lip-a-retrospective-study-of-24-cases
#1
N Katsoulas, K Tosios, A Sklavounou-Andrikopoulou
BACKGROUND: Lichenoid lesions of the upper labial mucosa, without other oral or extraoral manifestations seem to be rare. The clinicopathologic features of 24 such cases are presented and the pertinent literature is reviewed. MATERIALS AND METHODS: 24 Caucasian patients that clinically presented lichenoid features on the upper labial mucosa, with or without lichenoid lesions on the adjacent gingiva, were included in the study. Clinical features were extracted from the patients records, while dental plaque/calculus accumulation and composite resin restorations of the adjacent teeth were recorded...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29676534/consensus-based-european-guidelines-for-treatment-of-atopic-eczema-atopic-dermatitis-in-adults-and-children-part-i
#2
A Wollenberg, S Barbarot, T Bieber, S Christen-Zaech, M Deleuran, A Fink-Wagner, U Gieler, G Girolomoni, S Lau, A Muraro, M Czarnecka-Operacz, T Schäfer, P Schmid-Grendelmeier, D Simon, Z Szalai, J C Szepietowski, A Taïeb, A Torrelo, T Werfel, J Ring
This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This first part of the guideline covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy, whereas the second part covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions...
May 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29667789/updates-and-controversies-in-the-management-of-acute-optic-neuritis
#3
Ethan Meltzer, Sashank Prasad
Optic neuritis remains a common diagnosis with controversial management. Although typical optic neuritis is often associated with "good" recovery of visual acuity, patients are often left with persistent impairments of contrast sensitivity, color vision, and visual field. These permanent visual deficits correlate with structural injury to the anterior visual pathway and are closely linked to visual quality of life. High dose corticosteroids are commonly used for patients with acute optic neuritis...
April 18, 2018: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/29662064/the-use-of-electronic-alerts-in-primary-care-computer-systems-to-identify-the-excessive-prescription-of-short-acting-beta-2-agonists-for-people-with-asthma-a-systematic-review
#4
REVIEW
Shauna McKibben, Anna De Simoni, Andy Bush, Mike Thomas, Chris Griffiths
Computers are increasingly used to improve prescribing decisions in the management of long-term conditions however the effects on asthma prescribing remain unclear. We aimed to synthesise the evidence for the use of computerised alerts that identify excessive prescribing of short-acting beta2 -agonists (SABAs) to improve asthma management for people with asthma. MEDLINE, CINAHL, Embase, Cochrane and Scopus databases (1990-2016) were searched for randomised controlled trials using electronic alerts to identify excessive prescribing of SABAs for people with asthma in primary care...
April 16, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29659973/the-diagnostic-challenge-of-acquired-thrombotic-thrombocytopenic-purpura-in-children-case-report-and-review-of-the-literature
#5
Elise Schapkaitz, Tanya Marié Schickerling
Acquired thrombotic thrombocytopenic purpura (TTP) is a rare disease in children. Despite advances in diagnosis and treatment, acquired TTP remains a challenging disease due to the lack of a simple diagnostic test and the variable response to plasma exchange. Herein, we describe a case of a 5-year-old of black ethnicity boy who presented with a sudden onset of fatigue and body aches. Laboratory investigations revealed a thrombotic microangiopathic manifestation. TTP was diagnosed, and plasma exchange and corticosteroids were initiated, with an excellent response...
April 12, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29655837/outcomes-of-early-liver-transplantation-for-patients-with-severe-alcoholic-hepatitis
#6
Brian P Lee, Neil Mehta, Laura Platt, Ahmet Gurakar, John P Rice, Michael R Lucey, Gene Y Im, George Therapondos, Hyosun Han, David W Victor, Oren K Fix, Lisanne Dinges, Deepti Dronamraju, Christine Hsu, Michael D Voigt, Mary E Rinella, Haripriya Maddur, Sheila Eswaran, Jessica Hause, David Foley, R Mark Ghobrial, Jennifer L Dodge, Zhiping Li, Norah A Terrault
BACKGROUND & AIMS: The American Consortium of Early Liver Transplantation (LT) for Alcoholic Hepatitis comprises 12 centers from 8 United Network for Organ Sharing regions studying early LT (without mandated period of sobriety) for patients with severe alcoholic hepatitis (AH). We analyzed outcomes of these patients. METHODS: We performed a retrospective study of consecutive patients with a diagnosis of severe AH and no prior diagnosis of liver disease or episodes of AH, who underwent LT before 6 months of abstinence from 2006 through 2017 at 12 centers...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29642928/diagnostic-and-management-of-life-threatening-adult-onset-still-disease-a-french-nationwide-multicenter-study-and-systematic-literature-review
#7
Antoine Néel, Anaïs Wahbi, Benoit Tessoulin, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Cédric Bretonnière, Mohamed Hamidou
BACKGROUND: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenotype of life-threatening AOSD, including response to therapy and long-term outcome. METHODS: A multicenter case series of intensive care medicine (ICU) patients with life-threatening AOSD and a systematic literature review. RESULTS: Twenty patients were included...
April 11, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29625138/controlled-release-technology-for-anti-angiogenesis-treatment-of-posterior-eye-diseases-current-status-and-challenges
#8
Chi Ming Laurence Lau, Yu Yu, Ghodsiehsadat Jahamir, Ying Chau
Antiangiogenic therapeutics, such as corticosteroids, VEGF targeting antibodies and aptamers have been demonstrated effective in controlling retinal and choroidal neovascularization related vision loss. However, to manage the chronic conditions, it requires long term and frequent intravitreal injections of these drugs, resulting in poor patient compliance and suboptimal treatment. In addition, emerging drugs such as tyrosine kinase inhibitors and siRNAs received much expectations, but the late stage clinical trials encountered various obstacles...
April 3, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29624450/national-athletic-trainers-association-position-statement-evaluation-management-and-outcomes-of-and-return-to-play-criteria-for-overhead-athletes-with-superior-labral-anterior-posterior-injuries
#9
Lori A Michener, Jeffrey S Abrams, Kellie C Huxel Bliven, Sue Falsone, Kevin G Laudner, Edward G McFarland, James E Tibone, Charles A Thigpen, Timothy L Uhl
OBJECTIVE:   To present recommendations for the diagnosis, management, outcomes, and return to play of athletes with superior labral anterior-posterior (SLAP) injuries. BACKGROUND:   In overhead athletes, SLAP tears are common as either acute or chronic injuries. The clinical guidelines presented here were developed based on a systematic review of the current evidence and the consensus of the writing panel. Clinicians can use these guidelines to inform decision making regarding the diagnosis, acute and long-term conservative and surgical treatment, and expected outcomes of and return-to-play guidelines for athletes with SLAP injuries...
March 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29619934/assessing-synovitis-with-conventional-static-and-dynamic-contrast-enhanced-magnetic-resonance-imaging-in-knee-osteoarthritis
#10
Robert Gc Riis
Knee osteoarthritis (KOA) is one of the most common causes of physical disability in the elderly population. With an increasing ageing and obese population, the prevalence of KOA is expected to rise substantially. The needs for a better understanding of the disease and tools that can predict the course of the disease, for example following treatment, are therefore imperative. 

Inflammation has over the last years been recognised as an important factor for both the symptomatology and disease course in KOA...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29614243/safety-and-efficacy-of-a-halobetasol-tazarotene-fixed-combination-in-the-treatment-of-moderate-to-severe-plaque-psoriasis-results-of-two-phase-3-randomized-controlled-trials
#11
Linda Stein Gold, Mark G Lebwohl, Jeffrey L Sugarman, David M Pariser, Tina Lin, Gina Martin, Radhakrishnan Pillai, Robert Israel, Tage Ramakrishna
Topical corticosteroids are the mainstay of psoriasis treatment; long-term safety concerns limit use. Combination with tazarotene may optimize efficacy, minimizing safety/tolerability concerns, In patients with moderate-to-severe plaque psoriasis treated with HP/TAZ lotion, improvement is noted within 2 weeks with few adverse effects observed after 8 weeks., HP/TAZ lotion may provide a realistic topical option for psoriasis management.
March 31, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29605216/inhaled-corticosteroids-and-asthma-control-in-adult-onset-asthma-12-year-follow-up-study
#12
Iida Vähätalo, Pinja Ilmarinen, Leena E Tuomisto, Onni Niemelä, Hannu Kankaanranta
BACKGROUND: Prescribed inhaled corticosteroid (ICS) doses in asthma have been studied in cross-sectional settings whereas long-term follow-up studies have not been carried out. OBJECTIVE: To evaluate prescribed medication longitudinally by calculating cumulative ICS doses and dose changes in a cohort of new-onset adult asthma during 12 years and in different groups of asthma control. METHODS: A total of 203 patients were followed for 12 years as part of Seinäjoki Adult Asthma Study (SAAS)...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29554195/association-of-inhaled-corticosteroids-and-long-acting-%C3%AE-agonists-as-controller-and-quick-relief-therapy-with-exacerbations-and-symptom-control-in-persistent-asthma-a-systematic-review-and-meta-analysis
#13
Diana M Sobieraj, Erin R Weeda, Elaine Nguyen, Craig I Coleman, C Michael White, Stephen C Lazarus, Kathryn V Blake, Jason E Lang, William L Baker
Importance: Combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as the controller and the quick relief therapy termed single maintenance and reliever therapy (SMART) is a potential therapeutic regimen for the management of persistent asthma. Objective: To conduct a systematic review and meta-analysis of the effects of SMART in patients with persistent asthma. Data Sources and Study Selection: The databases of MEDLINE via OVID, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews were searched from database inception through August 2016 and updated through November 28, 2017...
March 19, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29540496/exacerbations-of-copd
#14
Christian Viniol, Claus F Vogelmeier
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. While COPD is a mainly chronic disease, a substantial number of patients suffer from exacerbations. Severe exacerbations are related to a significantly worse survival outcome. This review summarises the current knowledge on the different aspects of COPD exacerbations. The impact of risk factors and triggers such as smoking, severe airflow limitation, bronchiectasis, bacterial and viral infections and comorbidities is discussed...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29485138/counselling-and-management-for-anticipated-extremely-preterm-birth
#15
COMMENT
Brigitte Lemyre, Gregory Moore
Counselling couples facing the birth of an extremely preterm infant is a complex and delicate task, entailing both challenges and opportunities. This revised position statement proposes using a prognosis-based approach that takes the best estimate of gestational age into account, along with additional factors, including estimated fetal weight, receipt of antenatal corticosteroids, singleton versus multiple pregnancy, fetal status and anomalies on ultrasound and place of birth. This statement updates data on survival in Canada, long-term neurodevelopmental disability at school age and quality of life, with focus on strategies to communicate effectively with parents...
September 2017: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29482867/-asthma-and-the-microbiome
#16
REVIEW
C Barnig, C Martin
INTRODUCTION: It has been demonstrated recently that the respiratory tract, considered for a long time to be sterile in the healthy subject, contains a vast community of bacteria called the respiratory microbiome. This microbiome, like the intestinal microbiome, is in constant interaction with the immune system of the human host. This relationship has allowed us to formulate some new theories on the pathophysiology of asthma. BACKGROUND: The respiratory microbiome of the asthmatic differs quantitatively and qualitatively from that of the healthy subject...
February 23, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29476191/characteristics-of-macrolide-responders-in-persistent-post-surgical-rhinosinusitis
#17
G M Oakley, J M Christensen, R Sacks, P Earls, R J Harvey
INTRODUCTION: The anti-inflammatory effects of long term low dose macrolide therapy have shown benefit in the management of diffuse panbronchiolitis. Dramatic responses to macrolide in the upper airway are seen but our understanding of the patient phenotype predisposing to macrolide response in chronic rhinosinusitis (CRS) is poor. METHODS: A case control study was performed in a tertiary level rhinology practice of consecutive chronic rhinosinusitis patients placed on a 3-month low dose macrolide therapy after failing at least 3 months of corticosteroid irrigation therapy post-endoscopic sinus surgery...
February 24, 2018: Rhinology
https://www.readbyqxmd.com/read/29455359/eosinophilic-esophagitis-an-important-comorbid-condition-of-asthma
#18
REVIEW
Sandy R Durrani, Vincent A Mukkada, Theresa W Guilbert
Eosinophilic esophagitis and asthma are frequently found as comorbid conditions in children and adults along with other manifestations of atopic diathesis. These two conditions have similar T helper 2 responses-driven pathophysiology and share common management strategies such as using systemic corticosteroids and targeted anti-cytokine biologic therapies. Review of the literature finds that asthma is often a comorbid condition in eosinophilic esophagitis in both children and adults; however, the EoE-asthma relationship remains poorly characterized mechanistically and clinically...
February 18, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29440316/glial-fibrillary-acidic-protein-antibody-positive-meningoencephalomyelitis
#19
Angeliki Zarkali, Oliver Cousins, Dilan Athauda, Samuel Moses, Nicholas Moran, Sreedharan Harikrishnan
Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis is a newly described, possibly under-recognised, severe inflammatory condition of the nervous system. The clinical presentation is variable but most commonly is a combination of meningitis, encephalitis and myelitis; other manifestations may include seizures, psychiatric symptoms and tremor. There is a significant association with malignancies, often occult, and with other autoimmune conditions. Although the disease responds well to corticosteroids acutely, it typically relapses when these are tapered, and so patients need long-term immunosuppression...
February 9, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29416367/profile-of-dupilumab-and-its-potential-in-the-treatment-of-inadequately-controlled-moderate-to-severe-atopic-dermatitis
#20
REVIEW
Olabola Awosika, Lori Kim, Momina Mazhar, Monica Rengifo-Pardo, Alison Ehrlich
Atopic dermatitis (AD) is a common inflammatory skin disorder that manifests as eczematous lesions, often associated with allergic rhinitis and asthma. Historically, moderate-to-severe disease has been managed with systemic immunosuppression, such as oral corticosteroids, which result in relapse and limiting side effects. Due to recent advancements in the identification of interleukin (IL)-4 and IL-13 as key mediators in AD, new biological agents have been developed for treatment. Dupilumab is a recently approved monoclonal antibody that targets the alpha subunit of the IL-4 receptor and, thus, downregulates activity of IL-4 and IL-13...
2018: Clinical, Cosmetic and Investigational Dermatology
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