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https://www.readbyqxmd.com/read/28339683/addressing-beacon-re-identification-attacks-quantification-and-mitigation-of-privacy-risks
#1
Jean Louis Raisaro, Florian Tramèr, Zhanglong Ji, Diyue Bu, Yongan Zhao, Knox Carey, David Lloyd, Heidi Sofia, Dixie Baker, Paul Flicek, Suyash Shringarpure, Carlos Bustamante, Shuang Wang, Xiaoqian Jiang, Lucila Ohno-Machado, Haixu Tang, XiaoFeng Wang, Jean-Pierre Hubaux
The Global Alliance for Genomics and Health (GA4GH) created the Beacon Project as a means of testing the willingness of data holders to share genetic data in the simplest technical context-a query for the presence of a specified nucleotide at a given position within a chromosome. Each participating site (or "beacon") is responsible for assuring that genomic data are exposed through the Beacon service only with the permission of the individual to whom the data pertains and in accordance with the GA4GH policy and standards...
February 20, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28339599/a-single-nucleotide-polymorphism-in-coq9-affects-mitochondrial-and-ovarian-function-and-fertility-in-holstein-cows%C3%A2
#2
M Sofia Ortega, Stephanie Wohlgemuth, Paula Tribulo, Luiz G B Siqueira, Daniel J Null, John B Cole, Marcus V Da Silva, Peter J Hansen
A single missense mutation at position 159 of coenzyme Q9 (COQ9) (G→A; rs109301586) has been associated with genetic variation in fertility in Holstein cattle, with the A allele associated with higher fertility. COQ9 is involved in the synthesis of coenzyme COQ10, a component of the electron transport system of the mitochondria. Here we tested whether reproductive phenotype is associated with the mutation and evaluated functional consequences for cellular oxygen metabolism, body weight changes, and ovarian function...
February 3, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28339203/correction-to-nucleoside-nucleotide-and-non-nucleoside-inhibitors-of-hepatitis-c-virus-ns5b-rna-dependent-rna-polymerase
#3
Michael J Sofia, Wonsuk Chang, Phillip A Furman, Ralph T Mosley, Bruce S Ross
No abstract text is available yet for this article.
March 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28335519/translating-developmental-origins-improving-the-health-of-women-and-their-children-using-a-sustainable-approach-to-behaviour-change
#4
Mary Barker, Janis Baird, Tannaze Tinati, Christina Vogel, Sofia Strömmer, Taylor Rose, Rufia Begum, Megan Jarman, Jenny Davies, Sue Thompson, Liz Taylor, Hazel Inskip, Cyrus Cooper, Don Nutbeam, Wendy Lawrence
Theories of the developmental origins of health and disease imply that optimising the growth and development of babies is an essential route to improving the health of populations. A key factor in the growth of babies is the nutritional status of their mothers. Since women from more disadvantaged backgrounds have poorer quality diets and the worst pregnancy outcomes, they need to be a particular focus. The behavioural sciences have made a substantial contribution to the development of interventions to support dietary changes in disadvantaged women...
March 20, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28335285/graphene-and-carbon-quantum-dot-based-materials-in-photovoltaic-devices-from-synthesis-to-applications
#5
REVIEW
Sofia Paulo, Emilio Palomares, Eugenia Martinez-Ferrero
Graphene and carbon quantum dots have extraordinary optical and electrical features because of their quantum confinement properties. This makes them attractive materials for applications in photovoltaic devices (PV). Their versatility has led to their being used as light harvesting materials or selective contacts, either for holes or electrons, in silicon quantum dot, polymer or dye-sensitized solar cells. In this review, we summarize the most common uses of both types of semiconducting materials and highlight the significant advances made in recent years due to the influence that synthetic materials have on final performance...
August 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335001/fastkd1-and-fastkd4-have-opposite-effects-on-expression-of-specific-mitochondrial-rnas-depending-upon-their-endonuclease-like-rap-domain
#6
Erik Boehm, Sofia Zaganelli, Kinsey Maundrell, Alexis A Jourdain, Stéphane Thore, Jean-Claude Martinou
FASTK family proteins have been identified as regulators of mitochondrial RNA homeostasis linked to mitochondrial diseases, but much remains unknown about these proteins. We show that CRISPR-mediated disruption of FASTKD1 increases ND3 mRNA level, while disruption of FASTKD4 reduces the level of ND3 and of other mature mRNAs including ND5 and CYB, and causes accumulation of ND5-CYB precursor RNA. Disrupting both FASTKD1 and FASTKD4 in the same cell results in decreased ND3 mRNA similar to the effect of depleting FASTKD4 alone, indicating that FASTKD4 loss is epistatic...
March 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334931/rgf1p-rho1p-gef-is-required-for-double-strand-break-repair-in-fission-yeast
#7
Elvira Manjón, Tomás Edreira, Sofía Muñoz, Yolanda Sánchez
Rho GTPases are conserved molecules that control cytoskeletal dynamics. These functions are expedited by Rho GEFs that stimulate the release of GDP to enable GTP binding, thereby allowing Rho proteins to initiate intracellular signaling. How Rho GEFs and Rho GTPases protect cells from DNA damage is unknown. Here, we explore the extreme sensitivity of a deletion mutation in the Rho1p exchange factor Rgf1p to the DNA break/inducing antibiotic phleomycin (Phl). The Rgf1p mutant cells are defective in reentry into the cell cycle following the induction of severe DNA damage...
March 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334619/investigation-on-metal-tolerance-and-phytoremoval-activity-in-the-poplar-hybrid-clone-monviso-under-cu-spiked-water-potential-use-for-wastewater-treatment
#8
Fabrizio Pietrini, Daniela Di Baccio, Valentina Iori, Sofia Veliksar, Natalia Lemanova, Liudvika Juškaitė, Audrius Maruška, Massimo Zacchini
A serious concern for the environmental and human health is represented by the increasing copper (Cu) occurrence in agricultural soils and waters, because of the possible food contamination and bioaugmentation along the trophic chain. The request for the decontamination of different matrices with an environmentally sustainable technology as the phytoremediation should be addressed by selecting plant materials with improved pollutant tolerance and removal capability. With this purpose, plants of the hybrid poplar clone "Monviso" (Populus×generosa A...
March 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28334068/the-dyslexia-susceptibility-protein-kiaa0319-inhibits-axon-growth-through-smad2-signaling
#9
Filipa Franquinho, Joana Nogueira-Rodrigues, Joana M Duarte, Sofia S Esteves, Christin Carter-Su, Anthony P Monaco, Zoltán Molnár, Antonio Velayos-Baeza, Pedro Brites, Mónica M Sousa
KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early postnatal stages to adulthood and being downregulated by injury. This suggested that KIAA0319 participates in functions unrelated to neuronal migration. Supporting this hypothesis, overexpression of KIAA0319 repressed axon growth in hippocampal and dorsal root ganglia neurons; the intracellular domain of KIAA0319 was sufficient to elicit this effect...
February 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28333455/an-unusual-%C3%AE-carbon-hydroxylation-of-proline-promotes-active-site-maturation
#10
Vasiliki E Fadouloglou, Stavroula Balomenou, Michalis Aivaliotis, Dina Kotsifaki, Sofia Arnaouteli, Anastasia Tomatsidou, Georgios Efstathiou, Nikos Kountourakis, Sofia Miliara, Marianna Griniezaki, Aleka Tsalafouta, Spiros A Pergantis, Ivo G Boneca, Nicholas M Glykos, Vassilis Bouriotis, Michael Kokkinidis
The full extent of proline (Pro) hydroxylation has yet to be established, as it is largely unexplored in bacteria. We describe here a so far unknown Pro hydroxylation activity which occurs in active sites of polysaccharide deacetylases (PDAs) from bacterial pathogens, modifying the protein backbone at the Cα atom of a Pro residue to produce 2-hydroxyproline (2-Hyp). This process modifies with high specificity a conserved Pro, shares with the deacetylation reaction the same active site and one cata-lytic residue and utilizes molecular oxygen as source for the hydroxyl group oxygen of 2-Hyp...
March 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28333216/buddysuite-command-line-toolkits-for-manipulating-sequences-alignments-and-phylogenetic-trees
#11
Stephen R Bond, Karl E Keat, Sofia N Barreira, Andreas D Baxevanis
The ability to manipulate sequence, alignment, and phylogenetic tree files has become an increasingly important skill in the life sciences, whether to generate summary information or to prepare data for further downstream analysis. The command line can be an extremely powerful environment for interacting with these resources, but only if the user has the appropriate general-purpose tools on hand. BuddySuite is a collection of four independent yet interrelated command-line toolkits that facilitate each step in the workflow of sequence discovery, curation, alignment, and phylogenetic reconstruction...
February 25, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28332953/patterns-of-response-by-sociodemographic-characteristics-and-recruitment-methods-for-women-in-uk-population-surveys-and-cohort-studies
#12
Sarah J Howcutt, Anna L Barnett, Sofia Barbosa Boucas, Lesley A Smith
Women are an important public health focus, because they are more likely to experience some social determinants of disease, and they influence family health. Little research has explored the sociodemographic representativeness of women in research studies. We examined the representativeness of female respondents across four sociodemographic factors in UK population surveys and cohort studies. Six UK population-based health surveys (from 2009-2013) and eight Medical Research Council cohort studies (from 1991 to 2014) were included...
March 23, 2017: Women & Health
https://www.readbyqxmd.com/read/28331318/surface-modified-gatifloxacin-nanoparticles-with-potential-for-treating-central-nervous-system-tuberculosis
#13
Patricia Marcianes, Sofia Negro, Luis García-García, Consuelo Montejo, Emilia Barcia, Ana Fernández-Carballido
A new nanocarrier is developed for the passage of gatifloxacin through the blood-brain barrier to treat central nervous system tuberculosis. Gatifloxacin nanoparticles were prepared by nanoprecipitation using poly(lactic-co-glycolic acid) (PLGA) 502 and polysorbate 80 or Labrafil as surface modifiers. The evaluation of in vivo blood-brain barrier transport was carried out in male Wistar rats using rhodamine-loaded PLGA nanoparticles prepared with and without the surface modifiers. At 30 and 60 minutes after administration, nanoparticle biodistribution into the brain (hippocampus and cortex), lungs, and liver was studied...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28330761/quantification-of-4-methylimidazole-in-soft-drinks-sauces-and-vinegars-of-greek-market-using-two-liquid-chromatography-techniques
#14
Manolis N Tzatzarakis, Elena Vakonaki, Sofia Moti, Alegakis Athanasios, Christina Tsitsimpikou, Ioannis Tsakiris, Marina Goumenou, Alexander E Nosyrev, Apostolos K Rizos, Aristidis M Tsatsakis
The substance 4-methylimidazole (4-MEI) has raised several concerns regarding its toxicity to humans, although no harmonized classification has yet been decided. The regulatory limits for food products set by various authorities in Europe and the USA differ considerably. The purpose of the present study is to compare two liquid chromatography techniques in order to determine the levels of 4-MEI in food products from the Greek market and roughly estimate the possible exposure and relevant health risk for the consumers...
March 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28330653/complementary-role-of-cmr-to-conventional-screening-in-the-diagnosis-and-prognosis-of-cardiac-sarcoidosis
#15
Vasileios Kouranos, George E Tzelepis, Aggeliki Rapti, Sofia Mavrogeni, Konstantina Aggeli, Marousa Douskou, Sanjay Prasad, Nikolaos Koulouris, Petros Sfikakis, Athol Wells, Elias Gialafos
OBJECTIVES: The goal of this study was to assess the independent and collective diagnostic value of various modalities in cardiac sarcoidosis, delineate the role of cardiac magnetic resonance (CMR), and identify patients at risk. BACKGROUND: Cardiac sarcoidosis is associated with increased morbidity and mortality. CMR is a key modality in the evaluation of patients with cardiac symptoms, but the complementary role of CMR to conventional tests for the diagnosis of cardiac sarcoidosis is not fully defined...
March 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28330023/valeur-pronostique-des-anomalies-irm-%C3%A3-la-phase-aigu%C3%A3-de-l%C3%A2-%C3%A3-tat-de-mal-%C3%A3-pileptique-inaugural-de-l%C3%A2-adulte
#16
Marie Benaiteau, Luc Valton, Marine Ferrier, Manuela Kamsu, Sofia Pastura, Raluca Gramada, Hervé Dumas, Marie Denuelle, Jonathan Curot, Christophe Cognard, Jérémie Pariente, Fabrice Bonneville
No abstract text is available yet for this article.
March 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28327850/-the-clinical-person-centered-method-and-its-application-in-primary-healthcare
#17
María Sofía Cuba Fuentes, Zoila Olga de Los Milagros Romero Albino
The person-centered clinical method (PCCM) used in primary healthcare (PHC) is a useful tool to improve a person's approach to a health system that adequately responds to the needs of the population. PHC is built on the basis of a good health system, through compliance with its four attributes-first contact access, person focused care over time, comprehensiveness, and coordination of care-and it becomes an essential part of the growth of any nation that wants to provide quality healthcare. In conclusion, the PCCM is related to a strong PHC, as it is based on an approach focused on meeting people's needs...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28327836/-health-related-quality-of-life-of-the-elderly-population-in-a-rural-and-urban-area-of-peru
#18
Jean Hernandez-Huayta, Sofía Chavez-Meneses, Nilton Yhuri Carreazo
Objectives.: To assess the health related quality of life in a sample of elderly population in a rural and urban Peruvian area. Materials and methods.: A cross-sectional study was performed in elderly population from four rural districts and one urban from the period October 2014 to January 2016. The association between the area of residence and five sociodemographic variables was assessed with the chi square test. Using the Wilcoxon rank sum test and assessing size effect, WHOQoL-OLD and WHOQoL-BREF domain scores and global score of the former obtained in the survey were measured and compared...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28327801/analysis-of-the-seroprevalence-of-and-factors-associated-with-chagas-disease-in-an-endemic-area-in-northeastern-brazil
#19
Erlane Chaves Freitas, Maria de Fátima Oliveira, Arduina Sofia Ortet de Barros Vasconcelos, José Damião da Silva, Carlos Eduardo Menezes Viana, Kátia Cristina Morais Soares Gomes, Luciano Pamplona de Góes Cavalcanti
INTRODUCTION: Chagas disease (CD) is currently considered a neglected disease; hence, identifying the factors associated with its high prevalence is essential. This study aimed to identify the seroprevalence of and the possible factors associated with CD in inhabitants of the City of Limoeiro do Norte, Northeastern Brazil. METHODS: Between April and November 2013, blood collection was conducted and a semi-structured questionnaire was administered. Blood samples that showed positive or possible serology for anti-Trypanosoma cruzi antibodies based on indirect immunofluorescence, hemagglutination indirect, and an enzyme-linked immunosorbent assay were analyzed...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327731/scattering-properties-and-internal-structure-of-magnetic-filament-brushes
#20
Elena S Pyanzina, Pedro A Sánchez, Joan J Cerdà, Tomàs Sintes, Sofia S Kantorovich
Practical applications of polymer brush-like systems rely on a clear understanding of their internal structure. In the case of magnetic nanoparticle filament brushes, the competition between bonding and nonbonding interactions-including long range magnetic dipole-dipole interactions-makes the microstructure of these polymer brush-like systems rather complex. On the other hand, the same interactions open up the possibility to manipulate the meso- and macroscopic responses of these systems by applying external magnetic fields or by changing the background temperature...
March 22, 2017: Soft Matter
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