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https://www.readbyqxmd.com/read/29161798/intrapartum-care-quality-indicators-a-literature-review
#1
Elisa Lazzaretto, Antonella Nespoli, Simona Fumagalli, Elisabetta Colciago, Sofia Perego, Anna Locatelli
BACKGROUND: Quality of care is increasingly recognized as a critical aspect of the maternal and newborn health, mainly with respect to care around labour and delivery and in the immediate postnatal period. The Aim of this Review is to identify the recommended intrapartum care indicators in order to measure the quality of Midwifery care. METHODS: A structured literature search was conducted in August 2017 incorporating English and Italian language studies from 1993 and onwards to identify published articles on quality standards of intrapartum care...
November 21, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29161698/a-comparison-of-three-methods-for-the-detection-of-circulating-tumor-cells-in-patients-with-early-and-metastatic-breast-cancer
#2
Eleni Politaki, Sofia Agelaki, Stella Apostolaki, Dora Hatzidaki, Areti Strati, Filippos Koinis, Maria Perraki, Georgia Saloustrou, Giannis Stoupis, Galatea Kallergi, Maria Spiliotaki, Tereza Skaltsi, Evi Lianidou, Vassilis Georgoulias, Dimitrios Mavroudis
BACKGROUND: We directly compared CTC detection rates and prognostic significance, using three different methods in patients with breast cancer (BC). METHODS: Early (n=200) and metastatic (n=164) patients were evaluated before initiating adjuvant or first-line chemotherapy, using the CellSearchTM System, an RT-qPCR for CK-19 mRNA detection and by double immunofluorescence (IF) microscopy using A45-B/B3 and CD45 antibodies. RESULTS: Using the CellSearchTM System, 37% and 16...
November 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161492/bionomics-of-anopheles-nyssorhynchus-albimanus-diptera-culicidae-in-two-villages-of-the-way%C3%A3%C2%BAu-people-riohacha-la-guajira-colombia
#3
Airleth Sofía Díaz, Aura Isabel Sotelo, Catalina González-Uribe, Helena L Brochero
INTRODUCTION: Riohacha, capital of the department of La Guajira, reports the highest rates for malaria in the department, and the most vulnerable people are those of the Wayúu indigenous group. OBJECTIVE: To describe some aspects of the bionomics of the Anopheles species in two Wayúu settlements. MATERIALS AND METHODS: Two sampling events were carried out during dry and rainy seasons in Marbacella and El Horno (Riohacha, La Guajira). Immature stages of Anopheles spp...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29158497/germline-variation-in-adamtsl1-is-associated-with-prognosis-following-breast-cancer-treatment-in-young-women
#4
Latha Kadalayil, Sofia Khan, Heli Nevanlinna, Peter A Fasching, Fergus J Couch, John L Hopper, Jianjun Liu, Tom Maishman, Lorraine Durcan, Sue Gerty, Carl Blomqvist, Brigitte Rack, Wolfgang Janni, Andrew Collins, Diana Eccles, William Tapper
To identify genetic variants associated with breast cancer prognosis we conduct a meta-analysis of overall survival (OS) and disease-free survival (DFS) in 6042 patients from four cohorts. In young women, breast cancer is characterized by a higher incidence of adverse pathological features, unique gene expression profiles and worse survival, which may relate to germline variation. To explore this hypothesis, we also perform survival analysis in 2315 patients aged ≤ 40 years at diagnosis. Here, we identify two SNPs associated with early-onset DFS, rs715212 (P meta = 3...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29158416/tracking-the-genome-wide-outcomes-of-a-transposable-element-burst-over-decades-of-amplification
#5
Lu Lu, Jinfeng Chen, Sofia M C Robb, Yutaka Okumoto, Jason E Stajich, Susan R Wessler
To understand the success strategies of transposable elements (TEs) that attain high copy numbers, we analyzed two pairs of rice (Oryza sativa) strains, EG4/HEG4 and A119/A123, undergoing decades of rapid amplification (bursts) of the class 2 autonomous Ping element and the nonautonomous miniature inverted repeat transposable element (MITE) mPing Comparative analyses of whole-genome sequences of the two strain pairs validated that each pair has been maintained for decades as inbreds since divergence from their respective last common ancestor...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29158371/perception-of-curability-among-advanced-cancer-patients-an-international-collaborative-study
#6
Sriram Yennurajalingam, Luis Fernando Rodrigues, Omar Shamieh, Colombe Tricou, Marilène Filbet, Kyaw Naing, Akhileshwaran Ramaswamy, Pedro Emilio Perez-Cruz, Mary Jocelyn S Bautista, Sofia Bunge, Mary Ann Muckaden, Vikash Sewram, Sarah Fakrooden, Antonio Tejedor Noguera, Shobha S Rao, Diane Liu, Minjeong Park, Janet L Williams, Zhanni Lu, Hilda Cantu, David Hui, Suresh K Reddy, Eduardo Bruera
BACKGROUND: There are limited data on illness understanding and perception of cure among advanced cancer patients around the world. The aim of the study was to determine the frequency and factors associated with inaccurate perception of curability among advanced cancer patients receiving palliative care across the globe. MATERIALS AND METHODS: Secondary analysis of a study to understand the core concepts in end-of-life care among advanced cancer patients receiving palliative care from 11 countries across the world...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29157490/dynamic-nuclear-polarization-for-sensitivity-enhancement-in-modern-solid-state-nmr
#7
REVIEW
Aany Sofia Lilly Thankamony, Johannes J Wittmann, Monu Kaushik, Björn Corzilius
The field of dynamic nuclear polarization has undergone tremendous developments and diversification since its inception more than 6 decades ago. In this review we provide an in-depth overview of the relevant topics involved in DNP-enhanced MAS NMR spectroscopy. This includes the theoretical description of DNP mechanisms as well as of the polarization transfer pathways that can lead to a uniform or selective spreading of polarization between nuclear spins. Furthermore, we cover historical and state-of-the art aspects of dedicated instrumentation, polarizing agents, and optimization techniques for efficient MAS DNP...
November 2017: Progress in Nuclear Magnetic Resonance Spectroscopy
https://www.readbyqxmd.com/read/29157004/vanadium-inhalation-induces-retinal-m%C3%A3-ller-glial-cell-mgc-alterations-in-a-murine-model
#8
Silvana Cervantes-Yépez, Lorena Sofía López-Zepeda, Teresa Fortoul
BACKGROUND: Vanadium (V) is a transition metal adhered to suspended particles. Previous studies demonstrated that V inhalation causes oxidative stress in the ependymal epithelium, the choroid plexus on brain lateral ventricles and in the retina. Inhaled-V reaches the eye´s retina through the systemic circulation; however, its effect on the retina has not been widely studied. The Müller glial cell provides support and structure to the retina, facilitates synapses and regulates the microenvironment and neuronal metabolism...
November 20, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29156553/inclusion-complexes-of-copaiba-copaifera-multijuga-hayne-oleoresin-and-cyclodextrins-physicochemical-characterization-and-anti-inflammatory-activity
#9
Jonas Gabriel de Oliveira Pinheiro, Emanuella de Aragão Tavares, Sofia Santos da Silva, Juliana Félix Silva, Yasmim Maria Barbosa Gomes de Carvalho, Magda Rhayanny Assunção Ferreira, Adriano Antunes de Souza Araújo, Euzébio Guimarães Barbosa, Matheus de Freitas Fernandes Pedrosa, Luiz Alberto Lira Soares, Eduardo Pereira de Azevedo, Valdir Florêncio da Veiga Júnior, Ádley Antonini Neves de Lima
Complexation with cyclodextrins (CDs) is a technique that has been extensively used to increase the aqueous solubility of oils and improve their stability. In addition, this technique has been used to convert oils into solid materials. This work aims to develop inclusion complexes of Copaifera multijuga oleoresin (CMO), which presents anti-inflammatory activity, with β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) by kneading (KND) and slurry (SL) methods. Physicochemical characterization was performed to verify the occurrence of interactions between CMO and the cyclodextrins...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156006/diana-tarbase-v8-a-decade-long-collection-of-experimentally-supported-mirna-gene-interactions
#10
Dimitra Karagkouni, Maria D Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G Hatzigeorgiou
DIANA-TarBase v8 (http://www.microrna.gr/tarbase) is a reference database devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth version is the first database indexing >1 million entries, corresponding to ∼670 000 unique miRNA-target pairs. The interactions are supported by >33 experimental methodologies, applied to ∼600 cell types/tissues under ∼451 experimental conditions. It integrates information on cell-type specific miRNA-gene regulation, while hundreds of thousands of miRNA-binding locations are reported...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155976/description-of-a-mass-poisoning-in-a-rural-district-in-mozambique-the-first-documented-bongkrekic-acid-poisoning-in-africa
#11
Eduardo Samo Gudo, Kyla Cook, Amelia M Kasper, Alfredo Vergara, Cristolde Salomão, Fernanda Oliveira, Hamida Ismael, Cristovão Saeze, Carla Mosse, Quinhas Fernandes, Sofia Omar Viegas, Cynthia S Baltazar, Timothy J Doyle, Ellen Yard, Alaina Steck, Mayda Serret, Travis M Falconer, Sara E Kern, Jennifer L Brzezinski, James A Turner, Brian L Boyd, Ilesh V Jani
Background: On January 9, 2015, in a rural town in Mozambique, over 230 people became sick and 75 died from an illness linked to drinking pombe, a traditional alcoholic beverage. Methods: An investigation was conducted to identify cases and determine the cause of the outbreak. A case was defined as any resident of Chitima who developed any new or unexplained neurologic, gastrointestinal, or cardiovascular symptom from January 9 at 6:00 a.m. through January 12. We conducted medical record reviews; healthcare worker and community surveys; anthropological and toxicological investigations of local medicinal plants and commercial pesticides; and laboratory testing of the suspect and control pombe...
November 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29155117/pediatric-non-missile-penetrating-head-injury-case-series-and-literature-review
#12
REVIEW
Evangelos Drosos, Dimitrios Giakoumettis, Alexandros Blionas, Andreas Mitsios, Georgios Sfakianos, Marios Themistocleous
BACKGROUND: Pediatric non-missile penetrating head injury (NMPHI) is usually accidental attributed mainly to the softer skulls of growing children. However, it is a rather rare entity and therefore no consensus exists regarding treatment, in order to effectively prevent the immediate and long-term complications. Throughout the literature practice, essentials are mostly discussed in case reviews and case series in general population. No data originating from randomized studies are available due to ethical and practical limitations...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29154065/does-nurses-role-health-or-symptoms-influence-their-personal-use-of-ingestible-complementary-and-alternative-medicines
#13
Sofia Dimitrelis, Lin Perry, Robyn Gallagher, Christine Duffield, David Sibbritt, Rachel Nicholls, Xiaoyue Xu
OBJECTIVES: To investigate the influence of work-related characteristics, health, health behaviours and symptoms on ingestible biologically-based Complementary and Alternative Medicine (CAM) use within the Australian nursing and midwifery workforce. BACKGROUND: CAM use is widespread worldwide, but there is little research into nurses' and midwives' personal use of ingestible CAM in Australia. METHODS: An online survey in 2014-15 used validated instruments and items to examine use of ingestible biologically-based CAM (herbs, foods and vitamins, minerals, amino acids, enzymes and other supplements), and the health and work-related characteristics of 5041 nurses and midwives recruited through the New South Wales Nurses and Midwives Association and professional networks...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29153762/basic-and-clinical-approaches-for-fertility-preservation-and-restoration-in-cancer-patients
#14
REVIEW
Jose V Medrano, María Del Mar Andrés, Sofía García, Sonia Herraiz, Teresa Vilanova-Pérez, Ellen Goossens, Antonio Pellicer
As gonadotoxic adverse effects of antineoplastic treatments can result in infertility, gamete cryopreservation is routinely offered to patients as the strategy to preserve their fertility. However, there are many cases where gold standards cannot be applied, as is the case for prepubertal cancer patients and others unable to produce gametes or their precursors at the moment of diagnosis. With an increasing number of cancer survivors in our society, strategies using either cryopreserved gonadal tissue or stem cells have been developed to allow cancer survivors to achieve fatherhood, and recent advances in the field have increased public interest...
November 15, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/29152770/cytoplasmic-localization-of-the-cell-polarity-factor-scribble-supports-liver-tumor-formation-and-tumor-cell-invasiveness
#15
Shan Wan, Anne-Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell Tóth, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp-Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn
The loss of epithelial cell polarity plays an important role in the development and progression of liver cancer. However, the specific molecular mechanisms supporting tumor initiation and progression are poorly understood. In this study, transcriptome data and immunofluorescence stains of tissue samples derived from hepatocellular carcinoma (HCC) patients revealed that overexpression associated with cytoplasmic localization of the baso-lateral cell polarity complex protein Scribble (Scrib) correlated with poor prognosis of HCC patients...
November 20, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29152358/4-benzyl-1-4-nitro-phen-yl-1h-1-2-3-triazole-crystal-structure-and-hirshfeld-analysis
#16
Julio Zukerman-Schpector, Sofia Dallasta Pedroso, Lucas Sousa Madureira, Márcio Weber Paixão, Akbar Ali, Edward R T Tiekink
The mol-ecule in the title compound, C15H12N4O2, has a twisted L-shape with the dihedral angle between the aromatic rings of the N-bound benzene and C-bound benzyl groups being 70.60 (9)°. The nitro group is co-planar with the benzene ring to which it is connected [C-C-N-O torsion angle = 0.4 (3)°]. The three-dimensional packing is stabilized by a combination of methyl-ene-C-H⋯O(nitro), methyl-ene-C-H⋯π(phen-yl), phenyl-C-H⋯π(triazol-yl) and nitro-O⋯π(nitro-benzene) inter-actions, along with weak π(triazol-yl)-π(nitrobenzene) contacts [inter-centroid distance = 3...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29150483/correction-for-de-moraes-et-al-murine-model-for-preclinical-studies-of-var2csa-mediated-pathology-associated-with-malaria-in-pregnancy
#17
Luciana V de Moraes, Sebastien Dechavanne, Patrícia M Sousa, André Barateiro, Sónia F Cunha, Sofia Nunes-Silva, Flávia A Lima, Oscar Murillo, Claudio R F Marinho, Stephane Gangnard, Anand Srivastava, Joanna A Braks, Chris J Janse, Benoit Gamain, Blandine Franke-Fayard, Carlos Penha-Gonçalves
No abstract text is available yet for this article.
December 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29150078/bimodal-fluorescence-129-xe-nmr-probe-for-molecular-imaging-and-biological-inhibition-of-egfr-in-non-small-cell-lung-cancer
#18
Gaëlle Milanole, Bo Gao, Audrey Paoletti, Grégory Pieters, Christophe Dugave, Eric Deutsch, Sofia Rivera, Frédéric Law, Jean-Luc Perfettini, Emilie Mari, Estelle Léonce, Céline Boutin, Patrick Berthault, Hervé Volland, François Fenaille, Thierry Brotin, Bernard Rousseau
Although Non-Small Cell Lung Cancer (NSCLC) is one of the main causes of cancer death, very little improvement has been made in the last decades regarding diagnosis and outcomes. In this study, a bimodal fluorescence/(129)Xe NMR probe containing a xenon host, a fluorescent moiety and a therapeutic antibody has been designed to target the Epidermal Growth Factor Receptors (EGFR) overexpressed in cancer cells. This biosensor shows high selectivity for the EGFR, and a biological activity similar to that of the antibody...
November 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29149357/recommendations-for-mechanical-thrombectomy-in-patients-with-acute-ischemic-stroke-a%C3%A2-clinical-guide-by-the-hellenic-stroke-organization
#19
REVIEW
Panagiotis Papanagiotou, George Ntaios, Vasileios Papavasileiou, Klearchos Psychogios, Marios Psychogios, Anastasios Mpotsaris, Timolaos Rizos, Konstantinos Spengos, Miltiadis Gravanis, Sofia Vassilopoulou, Christos Gkogkas, Petros Zampakis, Panagiotis Zis, Apostolos Karantanas, Michail Karygiannis, Georgios Karydas, Eleni Korompoki, Konstantinos Makaritsis, Konstantinos Marmagkiolis, Haralambos Milionis, Dimos Mitsikostas, Dimitrios Nikas, Androniki Plomaritoglou, Maria Politi, Nikolaos Ptochis, Christos Savopoulos, Konstantinos Takis, Nikolaos Tsamopoulos, Dimitrios Tsetis, Adam Hatzidakis, Achilleas Chatziioannou, Apostolos Hatzitolios, Konstantinos Vemmos
This document presents the consensus recommendations of the Hellenic Stroke Organization which can be of assistance to the treating stroke physicians.
November 17, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29149092/analysis-of-the-roles-of-the-arabidopsis-nmat2-and-pmh2-proteins-provided-with-new-insights-into-the-regulation-of-group-ii-intron-splicing-in-land-plant-mitochondria
#20
Michal Zmudjak, Sofia Shevtsov, Laure D Sultan, Ido Keren, Oren Ostersetzer-Biran
Plant mitochondria are remarkable with respect to the presence of numerous group II introns which reside in many essential genes. The removal of the organellar introns from the coding genes they interrupt is essential for respiratory functions, and is facilitated by different enzymes that belong to a diverse set of protein families. These include maturases and RNA helicases related proteins that function in group II intron splicing in different organisms. Previous studies indicate a role for the nMAT2 maturase and the RNA helicase PMH2 in the maturation of different pre-RNAs in Arabidopsis mitochondria...
November 17, 2017: International Journal of Molecular Sciences
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