nalbufine

Anti-nociceptive and anti-inflammatory effects of methanolic extract of Wrightia arborea (MEWA) were examined using different models in rats. MEWA was given to rats orally upto 2000 mg kg(-1) b.wt. for acute toxicity study and observed for 14 days. Anti-nociceptive activity was evaluated in rats against Acetic acid induced writhing (chemically induced pain) and Tail immersion method (thermally induced pain). Acute anti-inflammatory activity of MEWA was also evaluated in Formaline-induced rat paw edema model and Carrageenan-induced hind paw edema model in rats...

Analgesic efficacy of nalbufine and buprenorphine is assessed in 86 patients with painful syndrome caused by unstable angina and acute myocardial infarction and in 72 patients with locomotor injuries, to whom urgent care was rendered by ambulance teams before hospitalization. By the velocity and depth of analgesic effect nalbufine is not inferior to morphine, and in patients with unstable angina and myocardial infarction is even superior to it. High analgesic activity of buprenorphine is compatible to that of morphine, but the rate of analgesia development is insufficient for urgent care...

Presents a clinician's viewpoint on the tolerance of and dependence on opiates and opioids in total anesthesia and management of acute (postoperative) and chronic (cancer) pain. Clinical observations are assessed with due consideration for the theoretical (pharmacological) studies. The author analyzes prolonged therapy with different opiates and opioids and the short-term use in massive doses at different stages of surgery. Tolerance to morphine rapidly forms during therapy of chronic pain, and the narcotic doses have to be progressively increased...

The effect of nalbufin hydrochloride (Nubain) on breathing was studied in 28 patients after abdominal operations. It was shown that, regardless of its partial effect on the mu-receptors, Nubain caused no respiratory disturbances. The authors recommend it for analgesia in abdominal operations, but only after careful evaluation of the general status and the respiratory function in the operated patient.

A new opioid analgetic (Nalbufin hydrochloride) was applied to 28 patients having undergone abdominal operations. The time of application of the analgetic agent was determined by the patient himself, in accordance with the five-grade classification of pain, offered by Beaver and Feise. It is pointed out that nalbufin hydrochloride has adequate analgetic power and duration of analgetic activity which makes it suitable for postoperative analgesia.