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obesity, diet, exercise

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https://www.readbyqxmd.com/read/28819990/effects-of-maternal-high-fat-diet-and-sedentary-lifestyle-on-susceptibility-of-adult-offspring-to-ozone-exposure-in-rats
#1
C J Gordon, P M Phillips, A F M Johnstone, J Schmid, M C Schladweiler, A Ledbetter, S J Snow, U P Kodavanti
Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-day-old female Long-Evans rats were fed a control (CD) or high-fat (HF) (60% calories) diet for 6 wks and then bred. GD1 rats were then housed with a running wheel (RW) or without a wheel (SED) until parturition, creating four groups of offspring: CD-SED, CD-RW, HF-SED and HF-RW...
August 18, 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28818415/modifiable-lifestyle-risk-factors-and-incident-diabetes-in-african-americans
#2
Joshua J Joseph, Justin B Echouffo-Tcheugui, Sameera A Talegawkar, Valery S Effoe, Victoria Okhomina, Mercedes R Carnethon, Willa A Hsueh, Sherita H Golden
INTRODUCTION: The associations of modifiable lifestyle risk factors with incident diabetes are not well investigated in African Americans (AAs). This study investigated the association of modifiable lifestyle risk factors (exercise, diet, smoking, TV watching, and sleep-disordered breathing burden) with incident diabetes among AAs. METHODS: Modifiable lifestyle risk factors were characterized among 3,252 AAs in the Jackson Heart Study who were free of diabetes at baseline (2000-2004) using baseline questionnaires and combined into risk factor categories: poor (0-3 points), average (4-7 points), and optimal (8-11 points)...
August 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28818261/contemporary-medical-therapies-of-atherosclerotic-carotid-artery-disease
#3
Suk F Cheng, Martin M Brown
Contemporary medical therapy consists of identification and treatment of all patient-modifiable vascular risk factors. Specific atherosclerotic disease therapies are designed to reduce the risk of thrombosis, and the disease progression in order to reduce the risk of future cardiovascular events. Contemporary medical management emphasizes the need to support the patient in achieving lifestyle modifications and to adjust medication to achieve individualized target values for specific quantifiable risk factors...
March 2017: Seminars in Vascular Surgery
https://www.readbyqxmd.com/read/28817856/back-to-basics-the-effect-of-healthy-diet-and-exercise-on-chronic-disease-management
#4
Robert L Allison
INTRODUCTION: The increase in obesity rates in the U.S. and other less developed industrial countries have led to a worldwide epidemic of chronic disease states. Increased obesity rates are implicated in the treatment failures for illnesses such as coronary artery disease, diabetes, heart failure, hypertension and cancer. Effective prevention of obesity through diet and exercise contributes to the successful medical management of multiple chronic disease states. OBJECTIVE: Review the last 10 years of literature (2006-2016) on the effects of diet and exercise as they relate to the prevention of chronic disease...
2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28815987/health-related-quality-of-life-in-randomized-controlled-trials-of-lorcaserin-for-obesity-management-what-mediates-improvement
#5
R L Kolotkin, R D Crosby, Z Wang
Lorcaserin, plus diet and exercise, has demonstrated significant weight loss and improved cardiometabolic parameters vs. placebo in patients with overweight/obesity in three randomized, placebo-controlled trials. We examined whether lorcaserin is also associated with greater improvements in health-related quality of life (HRQOL) and whether these improvements are wholly attributable to weight loss. Pooled data from Behavioral Modification and Lorcaserin for Overweight and Obesity Management (BLOOM), Behavioral Modification and Lorcaserin Second Study for Obesity Management (BLOSSOM) and BLOOM-Diabetes Mellitus (BLOOM-DM) trials were analysed (n = 5624)...
August 17, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28814391/filling-the-void-a-role-for-exercise-induced-bdnf-and-brain-amyloid-precursor-protein-processing
#6
Rebecca Ek MacPherson
Inactivity, obesity, and insulin resistance are significant risk factors for the development of Alzheimer's disease (AD). Several studies have demonstrated that diet induced obesity, inactivity, and insulin resistance exacerbates neuropathological hallmarks of AD. The aggregation of beta-amyloid peptides is one of these hallmarks. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in amyloid precursor protein (APP) processing, leading to beta-amyloid peptide formation...
August 16, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28810972/when-military-fitness-standards-no-longer-apply-the-high-prevalence-of-metabolic-syndrome-in-recent-air-force-retirees
#7
Marcus M Cranston, Mark W True, Jana L Wardian, Rishawn M Carriere, Tom J Sauerwein
BACKGROUND: Metabolic syndrome (MetS) is strongly associated with cardiovascular disease. With MetS prevalence rates increasing in the U.S. population, prevention efforts have largely focused on diet and exercise interventions. Before retirement, military service members have met fitness requirements for at least 20 years, and have lower MetS rates compared to age-matched U.S. population controls (23.4% vs. 39.0%), which suggests a protective effect of the lifestyle associated with military service...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28807645/a-behavioral-weight-loss-program-and-non-urinary-incontinence-lower-urinary-tract-symptoms-in-overweight-and-obese-women-with-urinary-incontinence-a-secondary-data-analysis-of-the-program-to-reduce-incontinence-by-diet-and-exercise-pride
#8
Benjamin N Breyer, Jennifer M Creasman, Holly E Richter, Deborah Myers, Kathryn L Burgio, Rena R Wing, Delia Smith West, John W Kusek, Leslee L Subak
AIMS: To determine whether a behavioral weight reduction intervention improves non-urinary incontinence (UI) lower urinary tract storage symptoms (LUTS) including urinary frequency, nocturia, urgency, at 6 months compared to a structured education program (control group) among overweight and obese women with UI. METHODS: The Program to Reduce Incontinence by Diet and Exercise (PRIDE) was a randomized clinical trial of 338 overweight or obese women with UI. Participants were randomized to 6-month behavioral weight loss intervention (N=226) or control (N=112)...
August 11, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28801940/examining-the-association-between-depression-and-obesity-during-a-weight-management-programme
#9
N R Fuller, J Burns, A Sainsbury, S Horsfield, F da Luz, S Zhang, G Denyer, T P Markovic, I D Caterson
The prevalence of depression in those with obesity is reported to be as high as double that in individuals of normal weight. There is potentially a bi-directional relationship between obesity and depression. Some research has suggested that depression results in weight gain and obesity, and other studies have suggested that those with obesity are more likely to develop depression at a later stage. The aim of this study was to investigate the association of depression symptoms with weight change over a 12-month study...
August 11, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28801668/exercise-leads-to-unfavourable-cardiac-remodelling-and-enhanced-metabolic-homeostasis-in-obese-mice-with-cardiac-and-skeletal-muscle-autophagy-deficiency
#10
Zhen Yan, Ana Kronemberger, Jay Blomme, Jarrod A Call, Hannah M Caster, Renata O Pereira, Henan Zhao, Vitor U de Melo, Rhianna C Laker, Mei Zhang, Vitor A Lira
Autophagy is stimulated by exercise in several tissues; yet the role of skeletal and cardiac muscle-specific autophagy on the benefits of exercise training remains incompletely understood. Here, we determined the metabolic impact of exercise training in obese mice with cardiac and skeletal muscle disruption of the Autophagy related 7 gene (Atg7(h&mKO)). Muscle autophagy deficiency did not affect glucose clearance and exercise capacity in lean adult mice. High-fat diet in sedentary mice led to endoplasmic reticulum stress and aberrant mitochondrial protein expression in autophagy-deficient skeletal and cardiac muscles...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801525/exercise-of-obese-mice-induces-cardioprotection-and-oxygen-sparing-in-hearts-exposed-to-high-fat-load
#11
Neoma T Boardman, Anne Dragøy Hafstad, Jim Lund, Line Rossvoll, Ellen Aasum
Exercise training is a potent, therapeutic approach in obesity and diabetes that exerts protective effects against development of diabetic cardiomyopathy and ischemic-injury. Acute increases in circulating fatty acids (FAs) during an ischemic insult can challenge the heart, as high FA-load is considered to have adverse cardiac effects. In the present study, we tested the hypothesis that exercise-induced cardiac effects in diet-induced obese mice are abrogated by an acute high FA-load. Diet-induced obese mice were fed a high-fat diet (HFD) for 20 weeks...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28801055/therapy-with-mesenchymal-stromal-cells-or-conditioned-medium-reverse-cardiac-alterations-in-a-high-fat-diet-induced-obesity-model
#12
P S Daltro, B C Barreto, P G Silva, P Chenaud Neto, P H F Sousa Filho, D Santana Neta, G B Carvalho, D N Silva, B D Paredes, A C de Alcantara, L A R Freitas, R D Couto, R R Santos, B S F Souza, M B P Soares, S G Macambira
BACKGROUND: Obesity is associated with numerous cardiac complications, including arrhythmias, cardiac fibrosis, remodeling and heart failure. Here we evaluated the therapeutic potential of mesenchymal stromal cells (MSCs) and their conditioned medium (CM) to treat cardiac complications in a mouse model of high-fat diet (HFD)-induced obesity. METHODS: After obesity induction and HFD withdrawal, obese mice were treated with MSCs, CM or vehicle. Cardiac function was assessed using electrocardiography, echocardiography and treadmill test...
August 8, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28792875/exercise-type-in-dieting-obese-older-adults
#13
LETTER
Leandro F M Rezende, Victor K R Matsudo
New England Journal of Medicine, Volume 377, Issue 6, Page 598-600, August 2017.
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28792874/exercise-type-in-dieting-obese-older-adults
#14
LETTER
Dennis T Villareal, Debra L Waters, Clifford Qualls
No abstract text is available yet for this article.
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28783384/clinical-physical-physiological-and-dietary-patterns-of-obese-and-sedentary-adults-with-primary-hypertension-characterized-by-sex-and-cardiorespiratory-fitness-exerdiet-hta-study
#15
Ilargi Gorostegi-Anduaga, Pablo Corres, Borja Jurio-Iriarte, Aitor Martínez-Aguirre, Javier Pérez-Asenjo, Gualberto R Aispuru, Lide Arenaza, Estibaliz Romaratezabala, Iñaki Arratibel-Imaz, Iñigo Mujika, Silvia Francisco-Terreros, Sara Maldonado-Martín
The main purpose of this study was to determine some key physical, physiological, clinical, and nutritional markers of health status in obese and sedentary adults (54.0 ± 8.1 years, 141 men and 68 women) with primary hypertension (HTN) characterized by sex and cardiorespiratory fitness (CRF) level. The studied population showed a high cardiovascular risk (CVR) profile including metabolically abnormal obese, with poor CRF level (22.5 ± 5.6 mL·kg(-1)·min(-1)), exercise-induced HTN (Systolic Blood Pressure>210 mmHg in men and >190 mmHg in women at the end of the exercise test) and with non-healthy adherence to dietary pattern (Dietary Approaches to Stop Hypertension, 46...
August 7, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28782917/dairy-attenuates-weight-gain-to-a-similar-extent-as-exercise-in-rats-fed-a-high-fat-high-sugar-diet
#16
Sarah K Trottier, Rebecca E K MacPherson, Carly M Knuth, Logan K Townsend, Willem T Peppler, John S Mikhaeil, Cam F Leveille, Paul J LeBlanc, Jane Shearer, Raylene A Reimer, David C Wright
OBJECTIVE: To compare the individual and combined effects of dairy and endurance exercise training in reducing weight gain and adiposity in a rodent model of diet-induced obesity. METHODS: An 8-week feeding intervention of a high-fat, high-sugar diet was used to induce obesity in male Sprague-Dawley rats. Rats were then assigned to one of four groups for 6 weeks: (1) casein sedentary (casein-S), (2) casein exercise (casein-E), (3) dairy sedentary (dairy-S), and (4) dairy exercise (dairy-E)...
August 7, 2017: Obesity
https://www.readbyqxmd.com/read/28779908/differential-effects-of-voluntary-treadmill-exercise-and-caloric-restriction-on-tau-pathogenesis-in-a-mouse-model-of-alzheimer-s-disease-like-tau-pathology-fed-with-western-diet
#17
Maud Gratuze, Jacinthe Julien, Françoise Morin, André Marette, Emmanuel Planel
BACKGROUND: Tau is a microtubule-associated protein that becomes pathological when it undergoes hyperphosphorylation and aggregation as seen in Alzheimer's disease (AD). AD is mostly sporadic, with environmental, biological and/or genetic risks factors, interacting together to promote the disease. In the past decade, reports have suggested that obesity in midlife could be one of these risk factors. On the other hand, caloric restriction and physical exercise have been reported to reduce the incidence and outcome of obesity as well as AD...
August 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28776758/aerobic-exercise-blocks-interleukin-6-levels-and-germ-cell-apoptosis-in-obese-rats
#18
N-C Li, X-X Wei, Y-L Hu, X Hou, H Xu
To investigate the effect of a high-fat diet and aerobic exercise intervention and its related mechanism on rat germ cell apoptosis. Forty male Sprague-Dawley rats were randomly divided into control group, high-fat diet group, control exercise group and high-fat exercise group. Rats were fed with high-fat diet or were given weight-free swimming. The levels of TG, TC, HDL, LDL and IL-6 in serum of rats were measured. The body weight, body length and inguinal fat weight were measured to calculate the Lee's index and lipid/body weight ratio...
August 3, 2017: Andrologia
https://www.readbyqxmd.com/read/28771283/medication-assisted-weight-loss-in-the-age-of-obesity
#19
Laura G Leahy
Obesity is a complex and potentially deadly health concern; yet, there are few medications available to treat this chronic, recurrent disease. Patients are frequently told to "lose weight" and change their diet and exercise habits. For many, making behavioral lifestyle changes is not enough to enhance weight loss efforts and improve overall health and quality of life. Medication-assisted weight loss must be considered as an adjunct treatment to lifestyle changes, as neither alone may provide the sustainable reduction in weight necessary to decrease the medical and psychiatric comorbidities associated with obesity...
August 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28764783/preferences-and-motivation-for-weight-loss-among-knee-replacement-patients-implications-for-a-patient-centered-weight-loss-intervention
#20
Christine A Pellegrini, Gwendolyn Ledford, Sara A Hoffman, Rowland W Chang, Kenzie A Cameron
BACKGROUND: Most knee replacement patients are overweight/obese, yet are commonly excluded from evidence-based weight loss programs due to mobility limitations and barriers faced around the time of surgery. The purpose of this study was to identify knee replacement patient preferences for weight loss programs and qualitatively understand previous motives for weight loss attempts as well as strategies used to facilitate behavior changes. METHODS: Patients who were either scheduled to have knee replacement or had one recently completed within the last 3 months were recruited to participate...
August 1, 2017: BMC Musculoskeletal Disorders
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