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obesity, diet, exercise

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https://www.readbyqxmd.com/read/28239482/aggressive-clinical-approach-to-obesity-improves-metabolic-and-clinical-outcomes-and-can-prevent-bariatric-surgery-a-single-center-experience
#1
Flavio A Cadegiani, Gustavo C Diniz, Gabriella Alves
BACKGROUND: The number of bariatric procedures has exponentially increased in the past decade, as a result of the lack of successful clinical weight-loss interventions. The main reasons for the failure of clinical obesity management are: (1) anti-obesity medications are administered as monotherapies (or pre-combined drugs); (2) lack of combination between pharmacotherapy and non-pharmacological modalities; (3) short duration of pharmacotherapy for obesity; (4) lack of weight-loss maintenance strategies; (5) misunderstanding of the complex pathophysiology of obesity; and (6) underprescription of anti-obesity medications...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28229608/usefulness-of-an-intra-gastric-balloon-before-bariatric-surgery
#2
Cristina Vicente, Luis Ramón Rábago, Alejandro Ortega, Marisa Arias, Jaime Vázquez Echarri
INTRODUCTION: There are only few reports regarding the use of intragastric-balloons (IGB®) to achieve weight loss and subsequently decrease surgical complications. In this study, we try to assess whether presurgery weight loss using IGB decreases the postsurgical mortality after bariatric surgery. METHODS: This is a prospective case-control study. We matched 1:1 by gender, age (± 10 y-o) and type of surgery (sleeve resection [LSG] or gastric bypass [LGBP]), matching cases (A) and controls (H, from a historic cohort)...
23, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28229538/biological-control-of-appetite-a-daunting-complexity
#3
Paul S MacLean, John E Blundell, Julie A Mennella, Rachel L Batterham
OBJECTIVE: This review summarizes a portion of the discussions of an NIH Workshop (Bethesda, MD, 2015) titled "Self-Regulation of Appetite-It's Complicated," which focused on the biological aspects of appetite regulation. METHODS: This review summarizes the key biological inputs of appetite regulation and their implications for body weight regulation. RESULTS: These discussions offer an update of the long-held, rigid perspective of an "adipocentric" biological control, taking a broader view that also includes important inputs from the digestive tract, from lean mass, and from the chemical sensory systems underlying taste and smell...
March 2017: Obesity
https://www.readbyqxmd.com/read/28228115/weight-loss-and-exercise-for-communities-with-arthritis-in-north-carolina-we-can-design-and-rationale-of-a-pragmatic-assessor-blinded-randomized-controlled-trial
#4
Stephen P Messier, Leigh F Callahan, Daniel P Beavers, Kate Queen, Shannon L Mihalko, Gary D Miller, Elena Losina, Jeffrey N Katz, Richard F Loeser, Sara A Quandt, Paul DeVita, David J Hunter, Mary F Lyles, Jovita Newman, Betsy Hackney, Joanne M Jordan
BACKGROUND: Recently, we determined that in a rigorously monitored environment an intensive diet-induced weight loss of 10% combined with exercise was significantly more effective at reducing pain in men and women with symptomatic knee osteoarthritis (OA) than either intervention alone. Compared to previous long-term weight loss and exercise trials of knee OA, our intensive diet-induced weight loss and exercise intervention was twice as effective at reducing pain intensity. Whether these results can be generalized to less intensively monitored cohorts is unknown...
February 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28224968/hematopoiesis-with-obesity-and-exercise-role-of-the-bone-marrow-niche
#5
Russell Emmons, Grace M Niemiro, Michael De Lisio
Hematopoietic stem and progenitor cells (HSPC), the most primitive cells of the hematopoietic system responsible for maintaining all mature blood cells, display the hallmark characteristics of self-renewal and multi-potent differentiation into mature cell lineages. HSPC activity is directed by the bone marrow niche, a complex environment composed of heterogeneous cell populations that regulate HSPC function through the secretion of a wide array of cytokines and growth factors. Diet induced obesity results in a dramatic remodeling of the bone marrow niche, skewing HSPC function resulting in a compromised immune system...
2017: Exercise Immunology Review
https://www.readbyqxmd.com/read/28222422/impact-of-diet-and-or-exercise-intervention-on-infrapatellar-fat-pad-morphology-secondary-analysis-from-the-intensive-diet-and-exercise-for-arthritis-idea-trial
#6
Aarón Leonardo Pogacnik Murillo, Felix Eckstein, Wolfgang Wirth, Daniel Beavers, Richard F Loeser, Barbara J Nicklas, Shannon L Mihalko, Gary D Miller, David J Hunter, Stephen P Messier
OBJECTIVES: The infrapatellar fat pad (IPFP) represents intra-articular adipose tissue that may contribute to intra-articular inflammation and pain by secretion of proinflammatory cytokines. Here we examined the impact of weight loss by diet and/or exercise interventions on the IPFP volume. METHODS: Intensive Diet and Exercise for Arthritis (IDEA) was a single-blinded, single-center, 18-month, prospective, randomized controlled trial that enrolled 454 overweight and obese older adults with knee pain and radiographic osteoarthritis...
February 22, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28216643/effect-of-an-obesity-prevention-program-focused-on-motivating-environments-in-childhood-a-school-based-prospective-study
#7
Y Yang, B Kang, E Y Lee, H K Yang, H-S Kim, S-Y Lim, J-H Lee, S-S Lee, B K Suh, K-H Yoon
BACKGROUND/OBJECTIVES: There has been an increasing global recognition of the need for effective strategies to prevent and control childhood obesity. In this study, we aimed to identify the effectiveness of an obesity prevention program focused on motivating environments in school. SUBJECTS/METHODS: In this school-based, prospective, quasi-experimental study, we enrolled three elementary (4th graders) and two middle (7th graders) schools located in Chungju, Korea...
February 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28215975/physical-activity-and-cardiovascular-prevention-is-healthy-urban-living-a-possible-reality-or-utopia
#8
REVIEW
Silvio Buscemi, Carla Giordano
Favoring correct lifestyles is the most important measure to contrast cardiovascular diseases and the epidemic of high cardiovascular risk conditions, such as obesity, diabetes, and hypertension. Lifestyle is a broad expression that includes diet, physical exercise, and psychological and socio-economic factors, each of which must be taken into due consideration because of their intertwining influences, which may be a barrier to healthy changes at both the individual and population levels. While physical activity has probably received less attention in the last decades, it is likely the most important among the modifiable risk factors for cardiovascular diseases...
February 16, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28208968/school-based-multicomponent-intervention-for-obese-children-in-udupi-district-south-india-a-randomized-controlled-trial
#9
Baby S Nayak, Vinod H Bhat
INTRODUCTION: Childhood obesity and overweight is a global epidemics and has been increasing in the developing countries. Childhood obesity is linked with increased mortality and morbidity independent of adult obesity. Declining physical activity, access to junk food and parenting style are the major determinants of overweight in children. Thus, there is a need for increasing the physical activity of children, educating the parents as well as the children on lifestyle modification. This can be achieved through implementation of multicomponent intervention...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208847/effect-of-different-phases-of-menstrual-cycle-on-cardio-respiratory-efficiency-in-normal-overweight-and-obese-female-undergraduate-students
#10
Nazrin Samsudeen, Archana Rajagopalan
INTRODUCTION: The influence of obesity on cardio-respiratory efficiency in the various phases of menstrual cycle is not well understood until now. As majority of Indian women have a favourable attitude towards participation in sports it is significant to understand the variation in exercise performance during different phases of menstrual cycle to have an optimum performance. AIM: To evaluate the endurance capacity and cardio-respiratory responses in normal, obese and overweight female undergraduate students during different phases of menstrual cycle...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208792/an%C3%A2-exercise-only%C3%A2-intervention%C3%A2-in%C3%A2-obese%C3%A2-fathers%C3%A2-restores%C3%A2-glucose%C3%A2-and%C3%A2-insulin%C3%A2-regulation%C3%A2-in%C3%A2-conjunction%C3%A2-with%C3%A2-the%C3%A2-rescue%C3%A2-of%C3%A2-pancreatic%C3%A2-islet%C3%A2-cell%C3%A2-morphology%C3%A2-and%C3%A2-microrna%C3%A2-expression%C3%A2-in%C3%A2-male%C3%A2-offspring
#11
Nicole O McPherson, Michelle Lane, Lauren Sandeman, Julie A Owens, Tod Fullston
Paternal obesity programs metabolic syndrome in offspring. Low-impact exercise in obese  males improves the metabolic health of female offspring, however whether this occurred in male  offspring remained unknown. C57BL/6NHsd (Harlan) mice were fed a control diet (CD; 6% fat, n =  7) or a high-fat diet (HFD; 21% fat, n = 16) for 18 weeks. After 9 weeks, HFD-fed mice either remained  sedentary (HH, n = 8) or undertook low-moderate exercise (HE, n = 8) for another 9 weeks...
February 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28198702/epigenetic-clock-analysis-of-diet-exercise-education-and-lifestyle-factors
#12
Austin Quach, Morgan E Levine, Toshiko Tanaka, Ake T Lu, Brian H Chen, Luigi Ferrucci, Beate Ritz, Stefania Bandinelli, Marian L Neuhouser, Jeannette M Beasley, Linda Snetselaar, Robert B Wallace, Philip S Tsao, Devin Absher, Themistocles L Assimes, James D Stewart, Yun Li, Lifang Hou, Andrea A Baccarelli, Eric A Whitsel, Steve Horvath
Behavioral and lifestyle factors have been shown to relate to a number of health-related outcomes, yet there is a need for studies that examine their relationship to molecular aging rates. Toward this end, we use recent epigenetic biomarkers of age that have previously been shown to predict all-cause mortality, chronic conditions, and age-related functional decline. We analyze cross-sectional data from 4,173 postmenopausal female participants from the Women's Health Initiative, as well as 402 male and female participants from the Italian cohort study, Invecchiare nel Chianti...
February 14, 2017: Aging
https://www.readbyqxmd.com/read/28192104/practical-use-of-pharmacotherapy-for-obesity
#13
Leon I Igel, Rekha B Kumar, Katherine H Saunders, Louis J Aronne
Obesity management requires a multidisciplinary approach, as there are many factors that contribute to the development of obesity as well as the preservation of excess weight once it has been gained. Diet, exercise and behavior modification are key components of treatment. In addition to lifestyle changes, weight gain secondary to medications is an important modifiable risk factor. Even after appropriate lifestyle modification, and medication adjustments (where possible) to avoid agents that can contribute to weight gain, many patients are still unable to achieve clinically meaningful weight loss...
February 9, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28188866/does-a-future-oriented-temporal-perspective-relate-to-body-mass-index-eating-and-exercise-a-meta-analysis
#14
Allison M Sweeney, Ileana Culcea
OBJECTIVE: The present study aimed to quantify the magnitude of the association between future temporal perspective and Body Mass Index (BMI), diet, and exercise, respectively, and to clarify whether subjective future-focus scales or delay-discounting tasks are a more robust predictor of health behaviors. METHODS: A systematic search was conducted for studies that included a dispositional measure of future temporal perspective and a measure of BMI, eating, and/or exercise behavior...
February 8, 2017: Appetite
https://www.readbyqxmd.com/read/28183820/sarcolipin-expression-is-not-required-for-the-mitochondrial-enzymatic-response-to-physical-activity-or-diet
#15
Daniel Gamu, Anton Trinh, Val A Farjado, Eric Bombardier, A Russell Tupling
In mice, transgenic manipulation of Ca(2+)-handling proteins is sufficient to alter the metabolic phenotype of muscle. We have previously shown that ablation of sarcolipin (SLN), a regulatory protein and uncoupler of sarco(endo)plasmic reticulum Ca(2+)-ATPases, leads to excessive diet-induced obesity and glucose intolerance in mice. However, it is unclear how loss of SLN per se affects muscle oxidative capacity and the ability of mitochondria to adapt to physiological stimuli such as exercise training or calorie overload...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28180933/voluntary-exercise-improves-murine-dermal-connective-tissue-status-in-high-fat-diet-induced-obesity
#16
Kende Lőrincz, Dóra Haluszka, Norbert Kiss, Nóra Gyöngyösi, András Bánvölgyi, Róbert Szipőcs, Norbert M Wikonkál
Obesity is a risk factor for several cardiovascular and metabolic diseases. Its influence on the skin is less obvious, yet certain negative effects of adipose tissue inflammation on the dermis have been suggested. Excess weight is closely associated with sedentary behavior, so any increase in physical activity is considered beneficial against obesity. To investigate the effects of obesity and physical exercise on the skin, we established a mouse model in which mice were kept either on a high-fat diet or received standard chow...
February 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28166780/effect-of-a-high-protein-diet-and-or-resistance-exercise-on-the-preservation-of-fat-free-mass-during-weight-loss-in-overweight-and-obese-older-adults-a-randomized-controlled-trial
#17
Amely M Verreijen, Mariëlle F Engberink, Robert G Memelink, Suzanne E van der Plas, Marjolein Visser, Peter J M Weijs
BACKGROUND: Intentional weight loss in obese older adults is a risk factor for accelerated muscle mass loss. We investigated whether a high protein diet and/or resistance exercise preserves fat free mass (FFM) during weight loss in overweight and obese older adults. METHODS: We included 100 overweight and obese adults (55-80 year) in a randomized controlled trial (RCT) with a 2 × 2 factorial design and intention-to-treat analysis. During a 10-week weight loss program all subjects followed a hypocaloric diet...
February 6, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28164449/role-of-sleep-and-circadian-disruption-on-energy-expenditure-and-in-metabolic-predisposition-to-human-obesity-and-metabolic-disease
#18
REVIEW
A W McHill, K P Wright
Weight gain, obesity and diabetes have reached alarming levels in the developed world. Traditional risk factors such as over-eating, poor nutritional choices and lack of exercise cannot fully account for the high prevalence of metabolic disease. This review paper examines the scientific evidence on two novel risk factors that contribute to dys-regulated metabolic physiology: sleep disruption and circadian misalignment. Specifically, fundamental relationships between energy metabolism and sleep and circadian rhythms and the impact of sleep and circadian disruption on metabolic physiology are examined...
February 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28163011/aerobic-endurance-training-improves-nonalcoholic-fatty-liver-disease-nafld-features-via-mir-33-dependent-autophagy-induction-in-high-fat-diet-fed-mice
#19
Parvin Ghareghani, Mehrnoosh Shanaki, Saeideh Ahmadi, Ali Reza Khoshdel, Neda Rezvan, Reza Meshkani, Maryam Delfan, Sattar Gorgani-Firuzjaee
Due to changes in life style, obesity and obesity related complication such as insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease caused worldwide health problems. Regular exercise has been frequently prescribed to combat metabolic complication of obesity but its molecular mechanism has not been fully illustrated. We investigated molecular mechanism of lipid lowering effect of exercise training in high fat diet fed mice by focusing on miR-33 expression and autophagy pathway. 24 mice were assigned to normal chow (NC) (n=8), high-fat diet (HFD) (n=16) group and subjected to NC and HFD for 13-weeks...
February 2, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28158925/mirnas-in-human-subcutaneous-adipose-tissue-effects-of-weight-loss-induced-by-hypocaloric-diet-and-exercise
#20
Malene M Kristensen, Peter K Davidsen, Andreas Vigelsø, Christina N Hansen, Lars J Jensen, Niels Jessen, Jens M Bruun, Flemming Dela, Jørn W Helge
OBJECTIVE: Obesity is central in the development of insulin resistance. However, the underlying mechanisms still need elucidation. Dysregulated microRNAs (miRNAs; post-transcriptional regulators) in adipose tissue may present an important link. METHODS: The miRNA expression in subcutaneous adipose tissue from 19 individuals with severe obesity (10 women and 9 men) before and after a 15-week weight loss intervention was studied using genome-wide microarray analysis...
February 3, 2017: Obesity
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