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Extrauterine growth restriction

Luciana Rodriguez-Guerineau, Miriam Perez-Cruz, María D Gomez Roig, Francisco J Cambra, Juan Carretero, Fredy Prada, Olga Gómez, Fátima Crispi, Joaquim Bartrons
Introduction The adaptive changes of the foetal heart in intrauterine growth restriction can persist postnatally. Data regarding its consequences for early circulatory adaptation to extrauterine life are scarce. The aim of this study was to assess cardiac morphometry and function in newborns with late-onset intrauterine growth restriction to test the hypothesis that intrauterine growth restriction causes cardiac shape and functional changes at birth. METHODS: A comprehensive echocardiographic study was performed in 25 neonates with intrauterine growth restriction and 25 adequate-for-gestational-age neonates...
October 30, 2017: Cardiology in the Young
Briar L McKenzie, Liza Edmonds, Ruth Thomson, Jillian J Haszard, Lisa A Houghton
Premature infants are at high risk of undernutrition and extrauterine growth restriction (EUGR). AIM: To evaluate the relation between nutrition practices and growth rate in preterm infants from birth to 36 weeks postmenstrual age (PMA). METHODS: Longitudinal data were collected retrospectively in 103 infants born <33-weeks gestation admitted to Dunedin NICU, New Zealand. Weight, length and head circumference at birth and 36-weeks PMA z-scores were calculated using the INTERGROWTH Preterm Growth Standard...
September 26, 2017: Journal of Pediatric Gastroenterology and Nutrition
A-S Pages, O Tandonnet, L Renesme
INTRODUCTION: Extrauterine growth restriction is associated with long-term effects on growth and neurodevelopmental outcomes in preterm infants. The objective of this study was to evaluate the effects of a change in nutritional policy on the postnatal growth of premature infants. METHOD: Prospective observational study carried out between 01/01/14 and 31/12/14 in all newborns under 33 weeks GA admitted to the Bordeaux University Hospital after modification of the nutrition policy at the beginning of January 2014...
September 16, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Ruud R G Bueters, Annelies Jeronimus-Klaasen, Roger J M Brüggemann, Lambertus P van den Heuvel, Michiel F Schreuder
BACKGROUND: Up to two-thirds of premature born neonates are treated for infections with aminoglycosides such as gentamicin. Although acute toxicities are well described, there is uncertainty on developmental changes after treatment of premature born neonates. We studied the effect of gentamicin and ceftazidime on kidney development in the rat. Additionally, we evaluated the modulating effect of extrauterine growth restriction. METHODS: On postnatal day (PND) 2, Wistar rats were cross-fostered into normal sized litters (12 pups) or large litters (20 pups) to create normal food (NF) or food restricted (FR) litters to simulate growth restriction and dosed daily intraperitoneally with placebo, 4 mg/kg of gentamicin or 50 mg/kg ceftazidime until PND 8...
July 11, 2017: Birth Defects Research
Giulia Genoni, Marco Binotti, Alice Monzani, Elena Bernascone, Ilaria Stasi, Gianni Bona, Federica Ferrero
AIM: This study evaluated whether an early aggressive nutrition (EAN) strategy could limit extrauterine growth restriction (EUGR) in a cohort of preterm infants. METHODS: This prospective nonrandomised interventional study was carried out in the neonatal intensive care unit of an Italian hospital from January 2013 to December 2015. The prevalence of EUGR was assessed in 100 infants with a gestational age of ≤34 weeks, 50 after the introduction of an EAN regimen in October 2014 and 50 before...
October 2017: Acta Paediatrica
Funda Tuzun, Ebru Yucesoy, Bora Baysal, Abdullah Kumral, Nuray Duman, Hasan Ozkan
AIM: This study aimed to compare the recently published prescriptive INTERGROWTH-21st standards with commonly used intrauterine based Fenton growth standards in terms of birth size classification and extrauterine growth restriction (EUGR) incidence in a sample of very preterm infants. METHODS: The anthropometric measures of preterm infants born before 32 weeks of gestation at the Dokuz Eylul University Hospital during the period from January 2012 to February 2016 were obtained at birth, at the 36th gestational weeks or at the time of discharge...
June 30, 2017: Journal of Maternal-fetal & Neonatal Medicine
Danielle L Morton, Keli M Hawthorne, Carolyn E Moore
Objective. Infants with intestinal failure or feeding intolerance are nutritionally compromised and are at risk for extrauterine growth restriction. The aim of the study was to evaluate growth velocities of infants with intestinal failure and feeding intolerance for the first three months of age and to determine growth percentiles at birth and at 40-week postmenstrual age (PMA). Methods. A chart review of infants followed by the Texas Children's Hospital Intestinal Rehabilitation Team was conducted from April 2012 to October 2014...
2017: Journal of Nutrition and Metabolism
Tanis R Fenton, Hilton T Chan, Aiswarya Madhu, Ian J Griffin, Angela Hoyos, Ekhard E Ziegler, Sharon Groh-Wargo, Susan J Carlson, Thibault Senterre, Diane Anderson, Richard A Ehrenkranz
CONTEXT: Clinicians assess the growth of preterm infants and compare growth velocity using a variety of methods. OBJECTIVE: We determined the numerical methods used to describe weight, length, and head circumference growth velocity in preterm infants; these methods include grams/kilogram/day (g/kg/d), grams/day (g/d), centimeters/week (cm/week), and change in z scores. DATA SOURCES: A search was conducted in April 2015 of the Medline database by using PubMed for studies that measured growth as a main outcome in preterm neonates between birth and hospital discharge and/or 40 weeks' postmenstrual age...
March 2017: Pediatrics
Natsuki Ohkawa, Hiromichi Shoji, Naho Ikeda, Hiroki Suganuma, Toshiaki Shimizu
AIM: Poor post-natal growth is related to later morbidity and poor cognitive development in preterm infants. We investigated the relationship between plasma insulin-like growth factor 1 (IGF-1), leptin, active ghrelin levels and post-natal growth in preterm infants small for gestational age (SGA). METHODS: Plasma IGF-1, leptin and active ghrelin levels were measured at birth and at 2, 4, 6 and 8 weeks after birth in 42 very low birthweight (VLBW) infants (born between 27 and 31 weeks of gestation), including 14 SGA infants with extrauterine growth restriction (EUGR), 6 SGA infants without EUGR and 22 appropriate-for-gestational-age infants...
January 2017: Journal of Paediatrics and Child Health
Montserrat Izquierdo, Antonio Federico Martínez-Monseny, Neus Pociello, Paloma Gonzalez, Ruth Del Rio, Martin Iriondo, Isabel Iglesias-Platas
BACKGROUND AND AIMS: Postnatal growth restriction remains a serious problem in very low-birth-weight infants. Enhanced parenteral supply of nutrients as soon as possible after birth is one of the strategies addressed to avoid extrauterine growth restriction. We aimed to analyze changes in growth patterns and in clinical outcomes in our unit after a change in our parenteral nutrition (PN) protocol. METHODS: We collected data from 2 time periods, comprising the 2 years before (period I) and the 2 years after (period II) the change of protocol...
October 2016: Nutrition in Clinical Practice
Ah Young Choi, Yong Wook Lee, Mea-Young Chang
PURPOSE: To identify the effects of modified parenteral nutrition (PN) and enteral nutrition (EN) regimens on the growth of very low birth weight (VLBW) infants. METHODS: The study included VLBW infants weighing <1,500 g, admitted to Chungnam National University Hospital between October 2010 and April 2014, who were alive at the time of discharge. Subjects were divided according to 3 periods: period 1 (n=37); prior to the PN and EN regimen being modified, period 2 (n=50); following the PN-only regimen modification, period 3 (n=37); following both PN and EN regimen modification...
April 2016: Korean Journal of Pediatrics
Jennifer V E Brown, Nicholas D Embleton, Jane E Harding, William McGuire
BACKGROUND: Exclusively breast milk-fed preterm infants may accumulate nutrient deficits leading to extrauterine growth restriction. Feeding preterm infants with multi-nutrient fortified human breast milk rather than unfortified breast milk may increase nutrient accretion and growth rates and may improve neurodevelopmental outcomes. OBJECTIVES: To determine whether multi-nutrient fortified human breast milk improves important outcomes (including growth and development) over unfortified breast milk for preterm infants without increasing the risk of adverse effects (such as feed intolerance and necrotising enterocolitis)...
May 8, 2016: Cochrane Database of Systematic Reviews
Elda Fischi-Gomez, Emma Muñoz-Moreno, Lana Vasung, Alessandra Griffa, Cristina Borradori-Tolsa, Maryline Monnier, François Lazeyras, Jean-Philippe Thiran, Petra S Hüppi
Higher risk for long-term cognitive and behavioral impairments is one of the hallmarks of extreme prematurity (EP) and pregnancy-associated fetal adverse conditions such as intrauterine growth restriction (IUGR). While neurodevelopmental delay and abnormal brain function occur in the absence of overt brain lesions, these conditions have been recently associated with changes in microstructural brain development. Recent imaging studies indicate changes in brain connectivity, in particular involving the white matter fibers belonging to the cortico-basal ganglia-thalamic loop...
2016: NeuroImage: Clinical
Ruud R G Bueters, Annelies Jeronimus-Klaasen, Nuria Maicas, Sandrine Florquin, Lambertus P van den Heuvel, Michiel F Schreuder
BACKGROUND: Diuretics are administered to neonates to control fluid balance. We studied whether clinical doses affected kidney development and function and whether extrauterine growth retardation (EUGR) could be a modulator. METHODS: Wistar rats were cross-fostered in normal food or food restricted litters at postnatal day (PND) 2 and treated daily with 0.9% NaCl, 5 mg/kg furosemide or 5 mg/kg hydrochlorothiazide (HCTZ) up to PND 8. Kidneys were evaluated on proliferation, apoptosis and a set of mRNA target genes at PND 8, glomerular- and glomerular generation count at PND 35, clinical pathology parameters at 3- and 9 months, neutrophil gelatinase-associated lipocalin at PND 8, 3 and 6 months, monthly blood pressure from 3 months onward and histopathology at study end...
2016: Nephron
Junko Ichikawa, Go Ichikawa, Yayoi Tsuboi, Ryota Kuribayashi, Yoshiyuki Watabe, Toshimi Sairenchi, Hiroshi Suzumura, Osamu Arisaka
BACKGROUND: The aim of this study was to verify whether lipid emulsion treatment aggravates infection and inflammation in very low-birthweight (VLBW) infants. STUDY DESIGN: Very low-birthweight (<1500 g) infants born at <32 weeks gestational age between October 2013 and October 2014 at Dokkyo Medical University Hospital (Mibu, Tochigi, Japan) were treated with or without i.v. nutrition with a lipid emulsion. Infants were excluded who had congenital abnormalities, could not receive i...
July 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Jingang Li, Masahisa Funato, Hiroshi Tamai, Hiroshi Wada, Masato Nishihara, Takashi Morita, Suzanne L Miller, Kayo Egashira
BACKGROUND: Very-low-birthweight infants (VLBWIs) are at high risk for suboptimal bone mineral density (BMD) and bone mineral content (BMC). Small-for-gestational-age (SGA) status also causes reduced bone mineralization in full-term infants. However, the impact of intrauterine and postnatal extrauterine growth on BMD and BMC in VLBWIs is inconclusive. METHODS: We retrospectively investigated n=68 VLBWIs, comprising 45 appropriate-for-gestational-age (AGA) and 23 SGA infants who underwent lumbar spine dual-energy X-ray absorptiometry at term-equivalent age...
January 2016: Early Human Development
José Villar, Francesca Giuliani, Zulfiqar A Bhutta, Enrico Bertino, Eric O Ohuma, Leila Cheikh Ismail, Fernando C Barros, Douglas G Altman, Cesar Victora, Julia A Noble, Michael G Gravett, Manorama Purwar, Ruyan Pang, Ann Lambert, Aris T Papageorghiou, Roseline Ochieng, Yasmin A Jaffer, Stephen H Kennedy
BACKGROUND: Charts of size at birth are used to assess the postnatal growth of preterm babies on the assumption that extrauterine growth should mimic that in the uterus. METHODS: The INTERGROWTH-21(st) Project assessed fetal, newborn, and postnatal growth in eight geographically defined populations, in which maternal health care and nutritional needs were met. From these populations, the Fetal Growth Longitudinal Study selected low-risk women starting antenatal care before 14 weeks' gestation and monitored fetal growth by ultrasonography...
November 2015: Lancet Global Health
Ruud R G Bueters, Annelies Klaasen, Nuria Maicas, Sandrine Florquin, Lambertus P van den Heuvel, Michiel F Schreuder
BACKGROUND: Prematurely born children with patent ductus arteriosus are treated with ibuprofen or indomethacin, which may inhibit kidney development. We determined whether clinical doses affected kidney development and function, with or without extrauterine growth retardation. METHODS: Wistar rats were cross-fostered in normal food (NF) or food restricted (FR) litters at postnatal day (PND) 2. On PND 3 to 4, three doses of 0.9% NaCl, 0.1 mg/kg indomethacin, or 10 mg/kg ibuprofen were administered via intraperitoneal injection with 12-hr intervals...
October 2015: Birth Defects Research. Part B, Developmental and Reproductive Toxicology
Daniel A Columbus, Julia Steinhoff-Wagner, Agus Suryawan, Hanh V Nguyen, Adriana Hernandez-Garcia, Marta L Fiorotto, Teresa A Davis
Most low-birth weight infants experience extrauterine growth failure due to reduced nutrient intake as a result of feeding intolerance. The objective of this study was to determine whether prolonged enteral leucine supplementation improves lean growth in neonatal pigs fed a restricted protein diet. Neonatal pigs (n = 14-16/diet, 5 days old, 1.8 ± 0.3 kg) were fed by gastric catheter a whey-based milk replacement diet with either a high protein (HP) or restricted protein (RP) content or RP supplemented with leucine to the same level as in the HP diet (RPL)...
September 15, 2015: American Journal of Physiology. Endocrinology and Metabolism
Chinthika Piyasena, Jessy Cartier, Batbayar Khulan, Karen French, Gopi Menon, Jonathan R Seckl, Rebecca M Reynolds, Amanda J Drake
BACKGROUND: Preterm infants are at increased risk of cardiometabolic disease in later life. Extrauterine growth restriction, catch-up growth, altered adiposity, and abnormal hypothalamic-pituitary-adrenal axis activity could be predisposing factors. Altered DNA methylation (5-methylcytosine, 5mC) might be one underlying mechanism. We hypothesised that preterm infants have altered 5mC at the linked differentially methylated region 2 (DMR2) of IGF2 and the H19 imprinting control region (H19 ICR) compared with term infants over the first year of life...
February 26, 2015: Lancet
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