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https://www.readbyqxmd.com/read/29683226/low-incidence-of-heparin-induced-skin-lesions-in-orthopedic-surgery-patients-with-low-molecular-weight-heparins
#1
M Schindewolf, M Paulik, H Kroll, R Kaufmann, M Wolter, W-H Boehncke, E Lindhoff-Last, A Recke, R J Ludwig
BACKGROUND: Heparins are widely prescribed for prevention and therapy of arterial and venous thromboembolic diseases. Heparin-induced skin lesions are the most frequent adverse effects of subcutaneous heparin treatment in non-surgical patients (7.5-39.8%); no data exist on surgical patients. Commonly, they are due to a delayed-type hypersensitivity reaction (DTH), but may also be a manifestation of life-threatening heparin-induced thrombocytopenia (HIT). Lesions of both entities resemble initially...
April 23, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29683035/is-peripherally-inserted-central-catheter-related-thrombosis-associated-with-abo-blood-group-a-case-control-pilot-study
#2
Raad A Haddad, Yanal Alnimer, Ahmed Abdalla, Carlos F Ríos-Bedoya, Ghassan Bachuwa
Peripherally inserted central catheter (PICC) use is associated with many complications including line-related thrombosis. Several studies and meta-analyses confirmed the increased risk to develop venous thromboembolism in non-O blood group individuals. Our pilot study aimed to examine whether PICC-related thrombosis is influenced by ABO blood group. We identified patients admitted to Hurley Medical Center between March 2012 and March 2016 who had PICC placed during their admission, had their ABO blood group identified in their medical record, and had upper extremity venous Doppler ultrasound performed on the same side of PICC...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29682124/primary-external-iliac-venous-aneurysm-a-case-report
#3
Minami Taki, Takashi Miura, Takahiro Kobayashi, Toshio Kasai, Takahisa Maruyama, Minako Hayakawa, Yu Matsumura, Fumitaka Yamaki, Uichi Ikeda
Primary iliac venous aneurysm is an exceedingly rare abnormality that can be complicated by pulmonary embolism, thrombosis, and rupture. Here we report the case of an otherwise healthy 40-year-old man with a unilateral external iliac vein aneurysm without any evidence of an arteriovenous fistula, proximal stenosis, or obstruction, as reported on computed tomography. Pulmonary embolism was diagnosed using 99m Tc-macroaggregated albumin scintigraphy. To prevent life-threatening complications, we treated the patient with anticoagulant therapy and performed aneurysmectomy with reconstruction using a saphenous vein graft patch...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29682116/treatment-outcomes-of-anticoagulant-therapy-and-temporary-inferior-vena-cava-filter-implantation-for-pregnancy-complicated-by-venous-thrombosis
#4
Nobuhiro Hara, Takamichi Miyamoto, Junji Yamaguchi, Takamasa Iwai, Sadahiro Hijikata, Keita Watanabe, Yuichiro Sagawa, Ryo Masuda, Ryoichi Miyazaki, Naoyuki Miwa, Masahiro Sekigawa, Tetsuo Yamaguchi, Yasutoshi Nagata, Toshihiro Nozato, Orie Kobayashi, Satoshi Umezawa, Toru Obayashi
Objective : Although deep vein thrombosis (DVT) followed by pulmonary thromboembolism (PE) is a critical complication during pregnancy, there have been few reports about its intrapartum management. We evaluated intrapartum management by using a temporary inferior vena cava filter (IVCF) in pregnant women with PE/DVT. Materials and Methods : Eleven women with PE/DVT during pregnancy between January 2004 and December 2016 were included. The patients were hospitalized for intravenous unfractionated heparin infusion after acute PE/DVT onset...
March 25, 2018: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29681458/characterization-of-profunda-femoris-vein-thrombosis
#5
Tana L Repella, Olga Lopez, Cherrie Z Abraham, Amir F Azarbal, Timothy K Liem, Erica L Mitchell, Gregory J Landry, Gregory L Moneta, Enjae Jung
OBJECTIVE: The incidence of and risk factors for profunda femoris vein (PFV) thrombosis are poorly characterized. We prospectively identified patients with PFV deep venous thrombosis (DVT) to characterize the demographics and anatomic distribution of proximal DVT in patients with PFV DVT. METHODS: A prospective study was conducted of patients at a tertiary care university hospital with DVT diagnosed by venous duplex ultrasound scanning between June 2014 and June 2015...
April 19, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29680334/open-heart-surgery-for-management-of-right-auricular-thrombus-related-to-central-venous-catheterization
#6
A F Ribeiro, I S Neto, I Maia, C Dias
Central venous catheters are widely used in critically ill patients; however, they are also associated with increased morbidity and mortality. The literature may underestimate the incidence of catheter-inducible right atrial thrombi that are asymptomatic but potentially life threatening. The recognized risk factors for its development include infections related to the catheter, endothelial injury secondary to mechanical and chemical damage induced by certain medications and infused fluids. The characteristics of the patient and the catheter, such as size, material, type, location and ease of insertion, as well as the duration of placement play an additional role...
April 19, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29679001/nonaneurysmal-perimesencephalic-subarachnoid-hemorrhage-as-an-atypical-initial-presentation-of-cerebral-venous-sinus-thrombosis-a-case-report
#7
Roaa R Amer, Eman A Bakhsh
BACKGROUND Subarachnoid hemorrhage is rarely the first presentation of cerebral venous sinus thrombosis. This case study emphasizes the presentation of perimesencephalic subarachnoid hemorrhage due to cerebral venous sinus thrombosis and the importance of neurovascular imaging for reliable diagnosis of nonaneurysmal perimesencephalic subarachnoid hemorrhage due to cerebral venous sinus thrombosis. CASE REPORT We describe a case of cerebral venous sinus thrombosis manifesting initially as subarachnoid hemorrhage...
April 21, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29678975/incidence-of-superficial-venous-thrombosis-in-primary-care-and-risk-of-subsequent-venous-thromboembolic-sequelae-a-retrospective-cohort-study-performed-with-routine-healthcare-data-from-the-netherlands
#8
Geert-Jan Geersing, Selma Cazemier, Frans Rutten, David A Fitzmaurice, Arno W Hoes
OBJECTIVES: Recent studies in referred populations of patients with superficial venous thrombosis (SVT) report risks of venous thromboembolic (VTE) sequelae (deep vein thrombosis or pulmonary embolism) as high as 25%. Likely, these estimates are lower in non-referred patients, but large-scale population-based studies are lacking. We aimed to estimate the incidence rate of SVT in primary care and quantify its risk of VTE sequelae. DESIGN: A retrospective cohort study, using International Classification of Primary Care coding (K94...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678687/clinical-characteristics-and-outcomes-of-patients-with-multiple-simultaneous-superficial-vein-thrombi
#9
Rishi Chopra, Luis R Leon, Nicos Labropoulos
BACKGROUND: Although unprovoked superficial venous thrombosis (SVT) has traditionally been considered a local, benign disorder, recent studies demonstrate that patients with SVT are at significant risk for deep venous thrombosis, pulmonary embolism, and other venous thromboembolism (VTE) events. Nevertheless, clinical management remains widely inconsistent. Moreover, patients with multiple, unprovoked SVTs of noncommunicating anatomic sites have not been previously described, and they may be at even increased risk for adverse outcomes...
April 17, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29676522/adalimumab-based-treatment-versus-dmards-for-venous-thrombosis-in-beh%C3%A3-et-syndrome-a-retrospective-study-of-70-patients-with-vascular-involvement
#10
Giacomo Emmi, Antonio Vitale, Elena Silvestri, Maria Boddi, Matteo Becatti, Claudia Fiorillo, Claudia Fabiani, Bruno Frediani, Lorenzo Emmi, Gerardo Di Scala, Matteo Goldoni, Alessandra Bettiol, Augusto Vaglio, Luca Cantarini, Domenico Prisco
OBJECTIVES: Since Behçet syndrome (BS) is the prototype of inflammation-induced thrombosis, immunosuppressants are recommended in place of anticoagulants. Here we assessed the clinical efficacy and the corticosteroid-sparing effect of adalimumab (ADA)-based treatment versus DMARDs in a large retrospective cohort of patients with BS-related venous thrombosis. METHODS: We retrospectively collected data from 70 BS patients treated with DMARDs or ADA-based regimens (ADA ± DMARDs) because of venous complications...
April 20, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29676361/a-37-year-old-male-with-extensive-cerebral-venous-thrombosis-clinicopathological-correlation-of-a-rare-case
#11
Deepti Mutreja, Rajeev Saxena, T V S V G K Tilak, Vanmalini Tewari, Nikhil Moorchung, Bhaskar Nandi
We present the autopsy findings and differential diagnosis of a 37-year-old immunocompetent male patient who presented primarily with extensive cerebral vein thrombosis and was found to have a rare association with JAK2V617F mutation positivity.
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676328/papilledema-revisiting-after-sinus-angioplasty-of-chronic-cerebral-venous-sinus-thrombosis
#12
Vaibhav Kumar Jain, Vivek Singh, Vikas Kannaujia, Priyadarshini Mishra, Rajendra Vishnu Phadke, Kumudini Sharma
This case series aimed to review the significance of revisiting papilledema after successful cerebral venous sinus thrombosis (CVST) management with sinus angioplasty. Four patients presented with blurring and transient obscuration of vision with papilledema, headache, tinnitus, and vomiting. On magnetic resonance venography and digital subtraction angiography, chronic transverse sinus thrombosis was diagnosed for which patients underwent endovascular intervention (stenting). After the resolution of CVST, patients developed the recurrence of symptoms which on digital subtraction angiography revealed dural arteriovenous malformation (DAVM)...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29675625/multidetector-ct-of-iatrogenic-and-self-inflicted-vascular-lesions-and-infections-at-the-groin
#13
REVIEW
Massimo Tonolini, Anna Maria Ierardi, Gianpaolo Carrafiello, Domenico Laganà
The number and complexity of endovascular procedures performed via either arterial or venous access are steadily increasing. Albeit associated with higher morbidity compared to the radial approach, the traditional common femoral artery remains the preferred access site in a variety of cardiac, aortic, oncologic and peripheral vascular procedures. Both transarterial and venous cannulation (for electrophysiology, intravenous laser ablation and central catheterisation) at the groin may result in potentially severe vascular access site complications (VASC)...
April 19, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29675086/rare-presentation-of-cerebral-venous-sinus-thrombosis-in-a-child
#14
Amar Taksande, Rewat Meshram, Purnima Yadav, Amol Lohakare
Cerebral venous sinus thrombosis (CVST) is a critical condition with significant morbidity and mortality. It primarily affects the young and healthy. CVST presents a diagnostic challenge due to its varied presentation patterns. We report the case of a 11-year-old boy diagnosed with CVST after presenting with a long history of continuous headache. He improved following anticoagulation therapy. Despite thorough investigation, no discernible underlying cause could be identified.
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674495/platelet-munc13-4-regulates-hemostasis-thrombosis-and-airway-inflammation
#15
Eduardo I Cardenas, Keegan Breaux, Qi Da, Jose R Flores, Marco A Ramos, Michael J Tuvim, Alan R Burns, Rolando E Rumbaut, Roberto Adachi
Platelet degranulation is crucial for hemostasis and may participate in inflammation. Exocytosis in platelets is mediated by SNARE proteins and should be controlled by Munc13 proteins. We found that platelets express Munc13-2 and -4. We assessed platelet granule exocytosis in Munc13-2 and -4 global and conditional KO mice, and observed that deletion of Munc13-4 ablates dense granule release and indirectly impairs alpha granule exocytosis. We found no exocytic role for Munc13-2 in platelets, not even in the absence of Munc13-4...
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29674482/bleomycin-sclerotherapy-for-eyelid-venous-malformations-as-an-alternative-to-surgery-or-laser-therapy
#16
Tomoyoshi Shigematsu, Michelle Sorscher, Evelyn C Dier, Alejandro Berenstein
PURPOSE: To evaluate the clinical outcome of patients with venous malformation (VM) involving the eyelid treated with bleomycin sclerotherapy. METHODS: A retrospective review was performed of 18 consecutive patients with VM involving the eyelid who underwent bleomycin sclerotherapy. Patients' clinical presentation, details of sclerotherapy, and post-sclerotherapy resolution of the lesion as well as any procedure-related complications were evaluated. RESULTS: Twelve women and six men of mean age 34...
April 19, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29674324/indications-for-the-performance-of-intracranial-endovascular-neurointerventional-procedures-a-scientific-statement-from-the-american-heart-association
#17
REVIEW
Clifford J Eskey, Philip M Meyers, Thanh N Nguyen, Sameer A Ansari, Mahesh Jayaraman, Cameron G McDougall, J Kevin DeMarco, William A Gray, David C Hess, Randall T Higashida, Dilip K Pandey, Constantino Peña, Hermann C Schumacher
Intracranial endovascular interventions provide effective and minimally invasive treatment of a broad spectrum of diseases. This area of expertise has continued to gain both wider application and greater depth as new and better techniques are developed and as landmark clinical studies are performed to guide their use. Some of the greatest advances since the last American Heart Association scientific statement on this topic have been made in the treatment of ischemic stroke from large intracranial vessel occlusion, with more effective devices and large randomized clinical trials showing striking therapeutic benefit...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29674240/the-impact-of-antipsychotics-as-a-risk-factor-for-thromboembolism
#18
REVIEW
Ewa A Ogłodek, Marek J Just, Anna D Grzesińska, Aleksander Araszkiewicz, Adam R Szromek
Patients with schizophrenia are predisposed toward developing cardiovascular disease. Although neuroleptics affect the cardiovascular system, it is also important to consider the consequences of the disease itself such as lower physical activity due to living on disability pension, inadequate nutrition, and/or nicotine addiction, being more common among patients with schizophrenia versus the general population. All these factors combined lead to an increased risk of death caused by cardiovascular conditions in schizophrenic patients...
December 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29672822/identification-of-novel-diagnostic-biomarkers-for-deep-venous-thrombosis
#19
Ashfaque A Memon, Kristina Sundquist, Mirnabi PirouziFard, Johan L Elf, Karin Strandberg, Peter J Svensson, Jan Sundquist, Bengt Zöller
The combination of a negative D-dimer and a Wells score can rule out, but not confirm, a diagnosis of deep venous thrombosis (DVT). We aimed to identify new diagnostic biomarkers for DVT and to investigate their relationship with hypercoagulability markers [D-dimer and activated protein C-protein C inhibitor (APC-PCI) complex]. We screened 92 cardiovascular-specific proteins in plasma samples from 45 confirmed DVT patients and 45 age- and sex-matched non-DVT patients selected from a prospective multicentre diagnostic management study (SCORE) by Proseek Multiplex CVDIII96×96 ...
April 19, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29672756/reduced-plasma-fibrin-clot-permeability-is-associated-with-recurrent-thromboembolic-events-in-patients-with-antiphospholipid-syndrome
#20
Magdalena Celinska-Löwenhoff, Michal Zabczyk, Teresa Iwaniec, Krzysztof Plens, Jacek Musial, Anetta Undas
Objectives: APS is associated with arterial and venous thrombosis. The unfavourable fibrin clot phenotype, including formation of dense and poorly lysable clots, has been reported in thrombotic APS. We investigated whether abnormal plasma clot properties are predictive of recurrent thromboembolism in APS. Methods: We followed 126 consecutive patients with thrombotic APS and 105 control subjects, without APS, matched for thrombotic events. Plasma fibrin clot permeability (Ks), turbidity measurements and clot lysis time were evaluated ⩾5 months after a thrombotic event...
April 17, 2018: Rheumatology
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