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Young colorectal cancer

In Sub Jung, Cheol Min Shin, Sung Jae Park, Young Soo Park, Hyuk Yoon, Hyun Jin Jo, Nayoung Kim, Dong Ho Lee
Background/Aims: To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas. Methods: Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement...
November 12, 2018: Intestinal Research
Ronen Brenner, Shaye Kivity, Marina Peker, Daniel Reinhorn, Lital Keinan-Boker, Barbara Silverman, Irena Liphsitz, Tamara Kolitz, Carmit Levy, Dekel Shlomi, Giora Pillar, Nir Peled
BACKGROUND: Several studies in animal models and human with obstructive sleep apnea syndrome (OSAS) demonstrated an increase in cancer aggressiveness and mortality. However, there is a need for further clinical evidence supporting a correlation between OSAS and cancer incidence. OBJECTIVES: To reveal whether OSAS presence and severity is correlated with cancer incidence in a large homogenous patients' cohort. METHODS: We analyzed a cohort of over 5,000 concurrently enrolled patients, age > 18, with suspected OSAS, from a tertiary medical academic center...
November 12, 2018: Respiration; International Review of Thoracic Diseases
Yuan He, Xiang Tao, Feifei Huang, Nan Jia, Yan Du, Jinming Yu, Weiwei Feng
Genetic factors play an important role in shaping the biologic characteristics of malignant tumors, especially in young patients. We aimed to determine the clinicopathologic features of endometrial cancer (EC) in patients younger than 50 years with a family history of cancer.Overall, 229 patients with EC, including 40 with a positive family history of cancer (PFH) and 189 with a negative family history of cancer (NFH), were enrolled in this case-control study. The family history of cancer in a 2-generation pedigree was recorded for the PFH group...
October 2018: Medicine (Baltimore)
Madhawa Neranjan Gunathilake, Jeonghee Lee, Young Ae Cho, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
[This corrects the article DOI: 10.18632/oncotarget.24136.].
October 9, 2018: Oncotarget
Yi Yang, Woo Kyun Bae, Ji-Yoon Lee, Yong Jae Choi, Kyung Hwa Lee, Myong-Suk Park, Young Hyun Yu, So-Yeon Park, Rui Zhou, İsa Taş, Chathurika Gamage, Man-Jeong Paik, Jae Hyuk Lee, Ik Joo Chung, Kyung Keun Kim, Jae-Seoun Hur, Sang Kyum Kim, Hyung-Ho Ha, Hangun Kim
Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor, liver, and plasma of a CT26 syngeneic mouse tumor xenograft model after oral administration, as determined by LC-MS/MS analysis. KU exhibited potent anticancer effects on colorectal cancer cells and inhibited liver metastasis in an orthotopic murine colorectal cancer model...
November 2, 2018: Scientific Reports
Jeong Eun Kim, Sung-Min Chun, Yong Sang Hong, Kyu-Pyo Kim, Sun Young Kim, Jihun Kim, Chang-Ohk Sung, Eun Jeong Cho, Tae Won Kim, Se Jin Jang
Next-generation sequencing (NGS) panels are widely used for defining tumor mutation profiles and determining treatment approaches. We performed targeted NGS with 382 genes in colorectal cancer with known microsatellite instability (MSI) status. After exclusion of germline alterations, load of somatic mutations and small insertion/deletion (indel) alterations were determined. In the test set, 79 patients with 41 microsatellite-stable (MSS) and 38 MSI tumors were included. There were 120 MSS and eight MSI-high tumors in the validation set...
October 30, 2018: Journal of Molecular Diagnostics: JMD
Joseph C Anderson, N Jewel Samadder
Should we adopt the recently published American Cancer Society (ACS) recommendations to screen adults at 45 years of age? The main reasons for adopting the recommendation include the increase of colorectal cancer (CRC) in the young, especially late-stage tumors. Screening at 45 years is also supported by predictive modeling, which the ACS employed using updated and improved models as compared to those previously used by the United States Preventive Services Task Force. Reasons against adopting include concerns with the models as well as diversion of scarce screening resources away from high-risk populations...
November 1, 2018: American Journal of Gastroenterology
Gemma N Jones, Claire Rooney, Nicola Griffin, Martine Roudier, Lucy A Young, Antonio Garcia-Trinidad, Gareth D Hughes, Jeffrey R Whiteaker, Zena Wilson, Rajesh Odedra, Lei Zhao, Richard G Ivey, William J Howat, Elizabeth A Harrington, J Carl Barrett, Antonio Ramos-Montoya, Alan Lau, Amanda G Paulovich, Elaine B Cadogan, Andrew J Pierce
BACKGROUND: AZD0156 and AZD6738 are potent and selective inhibitors of ataxia-telangiectasia-kinase (ATM) and ataxia-telangiectasia-mutated and Rad3-related (ATR), respectively, important sensors/signallers of DNA damage. METHODS: We used multiplexed targeted-mass-spectrometry to select pRAD50(Ser635) as a pharmacodynamic biomarker for AZD0156-mediated ATM inhibition from a panel of 45 peptides, then developed and tested a clinically applicable immunohistochemistry assay for pRAD50(Ser635) detection in FFPE tissue...
November 2, 2018: British Journal of Cancer
Michail Galanopoulos, Emmanouela Tsoukali, Filippos Gkeros, Marina Vraka, Georgios Karampekos, Gerassimos J Matzaris
Patients with long-standing ulcerative colitis (UC) and extensive Crohn's colitis (CC) are at increased risk for dysplasia and colorectal cancer (CRC). Several studies have shown that UC extending proximal to the rectum, CC involving at least 1/3 of the colon, co-existence of primary sclerosing cholangitis, undetermined or unclassified colitis, family history of CRC and young age at diagnosis appear to be independent risk factors for inflammatory bowel disease (IBD) - related CRC. Therefore, screening and surveillance for CRC in IBD patients is highly recommended by international and national guidelines, whilst colonoscopy remains the unequivocal tool in order to detect potentially resectable dysplastic lesions or CRC at an early stage...
October 16, 2018: World Journal of Gastrointestinal Endoscopy
Paulo Victoria Soares, Vinicius Kannen, Alceu Afonso Jordão Junior, Sergio Britto Garcia
Colorectal cancer (CRC) is the third most frequent malignancy worldwide. Coffee is the second most consumed drink in the globe and suggested to decrease the CRC risk. Here, we explored whether coffee, decaffeinated coffee, or caffeine impact on the development of colorectal carcinogenesis induced by the direct carcinogen N-methyl-N-nitro-N-nitrosoguanidine (MNNG) in rats. To this end, sixty-four young male Wistar rats were divided into eight groups of eight animals each. We analyzed the frequency of dysplastic crypts and expression of metallothionein as a biomarker of the cancer risk, as well the expression of phosphorylated H2A histone family/member X (γH2AX) for DNA damage and cyclooxygenase-2 (COX-2) for inflammatory response...
October 26, 2018: Nutrition and Cancer
Teresa Peccerella, Tatjana Arslic-Schmitt, Sebastian Mueller, Kirstin-Berit Linhart, Devanshi Seth, Helmut Bartsch, Helmut K Seitz
Chronic ethanol consumption is a risk factor for several human cancers. A variety of mechanisms may contribute to this carcinogenic effect of alcohol including oxidative stress with the generation of reactive oxygen species (ROS), formed via inflammatory pathways or as byproducts of ethanol oxidation through cytochrome P4502E1 (CYP2E1). ROS may lead to lipidperoxidation (LPO) resulting in LPO-products such as 4-hydoxynonenal (4-HNE) or malondialdehyde. These compounds can react with DNA bases forming mutagenic and carcinogenic etheno-DNA adducts...
2018: Advances in Experimental Medicine and Biology
Jin-Sung Jung, Ji-Yun Hong, Hyung-Hoon Oh, Sun-Seog Kweon, Jun Lee, Sang-Wook Kim, Geom-Seog Seo, Hyun-Soo Kim, Young-Eun Joo
BACKGROUND: Colorectal laterally spreading tumors (LSTs) are large, flat neoplasms that are usually treated using different endoscopic techniques based on their morphology, size, and histology. The aim of this study was to evaluate the clinical outcomes of LSTs with advanced histology treated by endoscopic resection. METHODS: A total of 246 LSTs with advanced histology [i.e., high-grade dysplasia (HGD) and adenocarcinoma (AC)] treated by endoscopic resection [i...
October 22, 2018: Surgical Endoscopy
Eunice Lee, Bulaporn Natipagon-Shah, Samantha Sangsanoi-Terkchareon, Umme Shefa Warda, Shin-Young Lee
This study examined factors related to colorectal cancer (CRC) screening uptake among Thais in the United States. A total of 121 Thais between 50 and 75 years of age, who were married and living in southern California participated in the survey (mean age = 61 years). Out of all the participants, only 21% of the participants had fecal occult blood tests, 21% had sigmoidoscopy, and 45% had colonoscopy that were within the recommended period. Overall, 55% of participants met CRC screening adherence criteria...
October 19, 2018: Journal of Community Health
Hui-Huang Lai, Li-Jyuan Lin, Liang-Yi Hung, Pai-Sheng Chen
Colorectal cancer (CRC) is a major health problem due to its high mortality rate. The incidence of CRC is increasing in young individuals. Oxaliplatin (OXA) is an approved third-generation drug and is used for first-line chemotherapy in CRC. Although current standard chemotherapy improves the overall survival of CRC patients, an increasing number of reports of OXA resistance in CRC therapy indicates that resistance has become an urgent problem in clinical applications. Dicer is a critical enzyme involved in miRNA maturation...
October 16, 2018: Biochemical and Biophysical Research Communications
Young Ae Cho, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Purpose: Both genetic and lifestyle factors contribute to the risk of colorectal cancer, but each individual factor has a limited effect. Therefore, we investigated the association between colorectal cancer and the combined effects of genetic factors or/and lifestyle risk factors. Materials and Methods: In a case-control study of 632 colorectal cancer patients and 1,295 healthy controls, we quantified the genetic risk score for colorectal cancer using 13 polymorphisms...
October 18, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Hee Jin Son, Nayoung Kim, Chin-Hee Song, Sun Min Lee, Ha-Na Lee, Young-Joon Surh
Background/Aims: Estrogen is known to have protective effect in colorectal cancer development. The aims of this study are to investigate whether estradiol treatment reduces inflammation in CCD841CoN, a female human colonic epithelial cell line and to uncover underlying mechanisms of estradiol effects. Methods: 17β-Estradiol (E2) effect was measured by Western blot after inducing inf lammation of CCD841CoN by tumor necrosis factor α (TNF-α). Expression levels of estrogen receptor α (ERα) and β (ERβ), cyclooxygenase-2 (COX-2), nuclear factor-κB (NF-κB), heme oxygenase-1 (HO-1), and NAD(P)H-quinone oxidoreductase-1 (NQO-1) were also evaluated...
October 22, 2018: Korean Journal of Internal Medicine
Ahmad Abdullah Madkhali, Sang-Hyun Shin, Ki Byung Song, Jae Hoon Lee, Dae Wook Hwang, Kwang Min Park, Young Joo Lee, Song Cheol Kim
The aim of the present study was to evaluate the short- and long-term outcomes of secondary metastasis to the pancreas in terms of overall survival (OS) and disease-free survival (DFS) after pancreatectomy.This retrospective study included 29 patients who underwent pancreatectomy for secondary metastasis to the pancreas between December 1995 and August 2016.The study group was divided into renal cell carcinoma (RCC) (17 patients) and non-RCC (12 patients). The non-RCC group had 5 cases of colorectal cancer and 7 of another primary origin...
October 2018: Medicine (Baltimore)
Shashank Sarvepalli, Carol A Burke, Marc Monachese, Rocio Lopez, Brandie H Leach, Lisa Laguardia, Margaret O'Malley, Matthew F Kalady, James M Church
INTRODUCTION: The timing of prophylactic colorectal surgery in patients with familial adenomatous polyposis (FAP) is based on the immediacy of the colorectal cancer risk. The ability to predict the need for surgery may help patients and their families plan in the context of life events and CRC risk. We created a model to predict the likelihood of surgery within 2 and 5 years of first colonoscopy at our institution. METHODS: A single institution hereditary colorectal syndrome (Cologene™) database was interrogated for all patients with FAP having a deleterious APC mutation...
October 17, 2018: American Journal of Gastroenterology
Tran Thi Xuan Mai, Yoon Young Lee, Mina Suh, Eunji Choi, Eun Young Lee, Moran Ki, Hyunsoon Cho, Boyoung Park, Jae Kwan Jun, Yeol Kim, Jin Kyoung Oh, Kui Son Choi
PURPOSE: This study aimed to investigate inequalities in colorectal cancer (CRC) screening rates in Korea and trends therein using the slope index of inequality (SII) and relative index of inequality (RII) across income and education groups. MATERIALS AND METHODS: Data from the Korean National Cancer Screening Survey, an annually conducted, nationwide cross-sectional survey, were utilized. A total of 17174 men and women aged 50 to 74 years were included for analysis...
November 2018: Yonsei Medical Journal
Yoon-Tae Kang, Young Jun Kim, Tae Hee Lee, Young-Ho Cho, Hee Jin Chang, Hyun-Moo Lee
Circulating tumor cells have emerged as biomarkers for estimating the tumor burden and metastatic potential of cancer patients. However, to date, most of studies and applications of circulating tumor cells have been conducted and applied to epithelial cancers such as breast, colorectal, and prostate tumor. The only FDA-cleared method, CellSearch, makes use of antibody against epithelial surface protein expressed on CTCs, thus obstructing wide application for various cancers with non-epithelial and semi-epithelial characteristics including renal cell carcinoma...
October 12, 2018: Scientific Reports
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