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https://www.readbyqxmd.com/read/29050339/aberrant-expression-of-oatp1b3-in-colorectal-cancer-liver-metastases-and-its-clinical-implication-on-gadoxetic-acid-enhanced-mri
#1
Seung Hyun Park, Honsoul Kim, Eun Kyung Kim, Hogeun Kim, Dong Kyu Choi, Yong Eun Chung, Myeong-Jin Kim, Jin-Young Choi
PURPOSE: To investigate the factors associated with hepatobiliary phase (HBP) enhancement at gadoxetic acid-enhanced magnetic resonance imaging (MRI) and to determine whether HBP images could be used to predict prognosis in patients with colorectal cancer liver metastasis (CRLM). RESULTS: Of the 96 total nodules, 65 and 31 nodules were in the mixed and clearly hypointense groups, respectively. In the 55 nodules without preoperative chemotherapy, organic anionic transporting polypeptide 1B3 (OATP1B3) expression was a significant factor regarding the HBP enhancement (P=0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049337/factors-affecting-pouch-related-outcomes-after-restorative-proctocolectomy
#2
Gyoung Tae Noh, Jeonghee Han, Min Soo Cho, Hyuk Hur, Byung Soh Min, Kang Young Lee, Nam Kyu Kim
PURPOSES: Restorative proctocolectomy (RPC) with ileal pouch anal anastomosis (IPAA) is the procedure of choice for patients with familial adenomatous polyposis (FAP) and ulcerative colitis (UC) despite morbidities that can lead to pouch failure. We aimed to identify factors associated with pouch-related morbidities. METHODS: A retrospective analysis of patients who underwent RPC with IPAA was performed. To investigate the factors associated with pouch-related morbidities, patients' preoperative demographic and clinical factors, and intraoperative factors were included in the analysis...
2017: PloS One
https://www.readbyqxmd.com/read/29048580/the-impact-of-young-age-on-the-prognosis-for-colorectal-cancer-a-population-based-study-in-taiwan
#3
Chia-Lin Chou, Chien-Jen Tseng, Yow-Ling Shiue
Background: The impact of age as a prognostic factor for patients with colorectal cancer (CRC) remains controversial, possibly due to heterogeneity between studies in terms of patient numbers, percentage of patients undergoing curative resection, percentage of patients receiving neoadjuvant therapy, or failure to adjust for potential confounding factors. This study used colorectal cancer survival data from the Taiwan Cancer Registry database in order to comprehensively analyze age as a prognostic factor...
November 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29033371/a-small-molecule-inhibitor-of-the-%C3%AE-catenin-tcf4-interaction-suppresses-colorectal-cancer-growth-in-vitro-and-in-vivo
#4
Seung Ho Shin, Do Young Lim, Kanamata Reddy, Margarita Malakhova, Fangfang Liu, Ting Wang, Mengqiu Song, Hanyong Chen, Ki Beom Bae, Joohyun Ryu, Kangdong Liu, Mee-Hyun Lee, Ann M Bode, Zigang Dong
Colorectal cancer is associated with aberrant activation of the Wnt pathway. β-Catenin plays essential roles in the Wnt pathway by interacting with T-cell factor 4 (TCF4) to transcribe oncogenes. We synthesized a small molecule, referred to as HI-B1, and evaluated signaling changes and biological consequences induced by the compound. HI-B1 inhibited β-catenin/TCF4 luciferase activity and preferentially caused apoptosis of cancer cells in which the survival is dependent on β-catenin. The formation of the β-catenin/TCF4 complex was disrupted by HI-B1 due to the direct interaction of HI-B1 with β-catenin...
September 27, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29030986/the-small-molecule-au14022-promotes-colorectal-cancer-cell-death-via-p53-mediated-g2-m-phase-arrest-and-mitochondria-mediated-apoptosis
#5
Hwani Ryu, Ky-Youb Nam, Jae Sung Kim, Sang-Gu Hwang, Jie-Young Song, Jiyeon Ahn
The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic cell death, with its activation capable of sensitizing cancer cells to radiotherapy or chemotherapy. To identify small molecules that induce apoptosis via increased p53 transcriptional activity, we used a novel in-house library containing 96 small-molecule compounds. Using a cell-based screening method with a p53-responsive luciferase-reporter assay system involving benzoxazole derivatives, we found that AU14022 administration significantly increased p53 transcriptional activity in a concentration-dependent manner...
October 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29023686/body-fatness-at-an-early-age-and-risk-of-colorectal-cancer
#6
Khemayanto Hidayat, Chun-Mei Yang, Bi-Min Shi
While there is convincing evidence that excess body fatness in adulthood is positively associated with colorectal cancer risk, the association between body fatness at an early age (≤30 years) and the risk of colorectal cancer has been equivocal. The present meta-analysis was performed to clarify this association. PubMed and Web of Science databases were searched for relevant studies that investigated this association. The risk estimates from each study were transformed into a continuous variable for each 5 kg/m(2) increase in body mass index (BMI)...
October 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29018780/comparison-of-colonoscopy-surveillance-outcomes-between-young-and-older-colorectal-cancer-patients
#7
Sung Bae Kim, Hyun Jung Lee, Soo Jung Park, Sung Pil Hong, Jae Hee Cheon, Won Ho Kim, Tae Il Kim
BACKGROUND: Young-onset colorectal cancer is uncommon, but the incidence is increasing. Despite several guidelines for colonoscopic surveillance following colorectal cancer resection, there is little consistency regarding the timing and age-adjusted strategies of surveillance colonoscopy after surgery of young-onset colorectal cancer. The aim of this study was to compare the outcomes of surveillance colonoscopy between sporadic colorectal cancer patients with young and older age after curative resection...
September 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28991084/association-among-obesity-metabolic-health-and-the-risk-for-colorectal-cancer-in-the-general-population-in-korea-using-the-national-health-insurance-service-national-sample-cohort
#8
Cheol Min Shin, Kyungdo Han, Dong Ho Lee, Yoon Jin Choi, Nayoung Kim, Young Soo Park, Hyuk Yoon
BACKGROUND: In Korea, the incidence of colorectal cancer has increased and obesity is on a rising trend because of a Westernized lifestyle in men. OBJECTIVE: The purpose of this study was to evaluate the relationship between metabolic health status, as well as BMI, and the incidence of colorectal cancer. DESIGN: This was a prospective cohort study. SETTINGS: The study was conducted with the National Health Insurance Service-National Sample Cohort...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28988047/the-identification-of-lynch-syndrome-in-congolese-colorectal-cancer-patients
#9
Henriette Poaty, Chandra Aba Gandzion, Isabelle Soubeyran, Déby Gassaye, Jean Félix Peko, Jean Bernard Nkoua Bon, Charles Gombé Mbalawa
BACKGROUND: We aimed to investigate the prevalence of Lynch syndrome as one of hereditary causes of colorectal cancer (CRC) among young Congolese individuals affected by the CRC, and to define methods for diagnosis in Congo Brazzaville. METHODS: We conducted a transversal cohort study of 34 patients having a CRC with a family history for a period of eight years. They were selected among 89 CRCs of any type from the Bethesda guidelines criteria combined with pedigrees...
October 5, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28987237/effect-of-home-based-exercise-intervention-on-fasting-insulin-and-adipocytokines-in-colorectal-cancer-survivors-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Mi Kyung Lee, Ji-Young Kim, Dong-Il Kim, Dong-Woo Kang, Ji-Hye Park, Ki-Yong Ahn, Hyuk In Yang, Dong Hoon Lee, Yun Ho Roh, Ji-Won Lee, Sang-Hui Chu, Jeffrey A Meyerhardt, Lee W Jones, Nam-Kyu Kim, Justin Y Jeon
BACKGROUND AND AIMS: Elevated circulating insulin is associated with increased risk of recurrence and cancer mortality in early-stage colorectal cancer (CRC). We conducted a randomized controlled trial to determine the effect of a 12-week home-based exercise program on fasting insulin, adipocytokines, and physical function in CRC survivors. METHODS: One hundred and twenty-three stage II-III CRC patients were randomly assigned to either a home-based exercise (n=62) or standard care control group (n=61) for 12weeks...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28977010/clinicopathological-features-of-laterally-spreading-colorectal-tumors-and-their-association-with-advanced-histology-and-invasiveness-an-experience-from-honam-province-of-south-korea-a-honam-association-for-the-study-of-intestinal-diseases-hasid
#11
Dae-Seong Myung, Sun-Seog Kweon, Jun Lee, Ik-Sang Shin, Sang-Wook Kim, Geom-Seog Seo, Hyun-Soo Kim, Young-Eun Joo
BACKGROUND AND AIMS: Laterally spreading colorectal tumors (LSTs) are divided into four subtypes, including homogenous (HG), nodular mixed (NM), flat elevated (FE), and pseudo-depressed (PD), based on their different endoscopic morphologies. The aim of this study was to investigate the clinicopathological significance of LST subtypes and their association with advanced histology. METHODS: We investigated the medical records of consecutive patients with LST who initially underwent endoscopic resection at five university hospitals in Honam province of South Korea between January 2012 and December 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28976535/distrust-in-health-care-and-cultural-factors-are-associated-with-uptake-of-colorectal-cancer-screening-in-hispanic-and-asian-americans
#12
Young-Rock Hong, Justin Tauscher, Michelle Cardel
BACKGROUND: There are racial/ethnic disparities in colorectal cancer (CRC) screening, including lower uptake rates among Hispanic Americans (HAs) and Asian Americans (AAs) relative to non-Hispanic white Americans. The objective of this study was to explore pathways associated with the use of health services and to characterize multifaceted associations with the uptake of CRC screening among HAs and AAs. METHODS: Data were obtained from the Medical Expenditure Panel Survey (2012-2013)...
October 4, 2017: Cancer
https://www.readbyqxmd.com/read/28973012/the-relationship-between-drinking-alcohol-and-esophageal-gastric-or-colorectal-cancer-a-nationwide-population-based-cohort-study-of-south-korea
#13
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han, Hyun Soo Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim
BACKGROUND: Epidemiologic findings of low-volume alcohol consumption in relation to gastrointestinal cancers including gastric cancer are inconsistent. METHODS: The association between alcohol intake and esophageal, gastric and colorectal cancer risk was examined in a population-based prospective cohort of 23,323,730 adults in Korea who had undergone a biennial evaluation provided by the National Health Insurance Corporation between the years 2009 and 2012. After median 5...
2017: PloS One
https://www.readbyqxmd.com/read/28964611/incidental-detection-of-colorectal-lesions-by-fdg-pet-ct-scans-in-melanoma-patients
#14
Christopher J Young, Assad Zahid, Ian Choy, John F Thompson, Robyn P M Saw
BACKGROUND: Increased use of PET/CT scans in oncology patients has raised detection of Colorectal incidentalomas (CIs). The frequency and diagnostic outcomes of identifying these lesions in melanoma patients have not previously been studied. This studies primary objective was to determine the prevalence of CIs found on PET/CT scans in melanoma patients. The secondary objectives were to correlate the PET/CT findings with the pathology found at colonoscopy, and identify which patients were referred for colonoscopy...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28960834/the-application-of-crowdsourcing-approaches-to-cancer-research-a-systematic-review
#15
REVIEW
Young Ji Lee, Janet A Arida, Heidi S Donovan
Crowdsourcing is "the practice of obtaining participants, services, ideas, or content by soliciting contributions from a large group of people, especially via the Internet." (Ranard et al. J. Gen. Intern. Med. 29:187, 2014) Although crowdsourcing has been adopted in healthcare research and its potential for analyzing large datasets and obtaining rapid feedback has recently been recognized, no systematic reviews of crowdsourcing in cancer research have been conducted. Therefore, we sought to identify applications of and explore potential uses for crowdsourcing in cancer research...
September 29, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28960448/environmental-contributions-to-gastrointestinal-and-liver-cancer-in-the-asia-pacific-region
#16
REVIEW
Kwang-Pil Ko, Aesun Shin, Sooyoung Cho, Sue K Park, Keun-Young Yoo
In the Asia-Pacific region, gastric, colorectal and hepatocellular [liver] cancer show substantial regional variation in incidence consistent with the presence of important environmental factors. For gastric cancer, global incidence is concentrated in Asia with substantially higher rates in East Asia than in South-East Asia and Australia. The differences in incidence rates for gastric cancer in the Asia-Pacific region may be due, in part, to differences in the prevalence of H. pylori infection and the prevalence of H...
September 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28948490/rectal-cancer-in-asian-vs-western-countries-why-the-variation-in-incidence
#17
REVIEW
Yanhong Deng
Colorectal cancer (CRC) is the third most common cancer worldwide. CRC has been thought to be less common in Asia compared to Western countries. However, the incidence rates of CRC in Asia are high and there is an increasing trend in the Asian population. Furthermore, colorectal cancer accounts for the greatest number of all incidences of CRC in Asia. The increasing adoption of a Western lifestyle, particularly in dietary habits, is likely the most important factor contributing to the rapid increase in colon cancer incidence; it is noteworthy that trends for rectal cancer were flat...
September 25, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28944238/targeted-sequencing-of-36-known-or-putative-colorectal-cancer-susceptibility-genes
#18
Melissa S DeRycke, Shanaka Gunawardena, Jessica R Balcom, Angela M Pickart, Lindsey A Waltman, Amy J French, Shannon McDonnell, Shaun M Riska, Zachary C Fogarty, Melissa C Larson, Sumit Middha, Bruce W Eckloff, Yan W Asmann, Matthew J Ferber, Robert W Haile, Steven Gallinger, Mark Clendenning, Christophe Rosty, Aung K Win, Daniel D Buchanan, John L Hopper, Polly A Newcomb, Loic Le Marchand, Ellen L Goode, Noralane M Lindor, Stephen N Thibodeau
BACKGROUND: Mutations in several genes predispose to colorectal cancer. Genetic testing for hereditary colorectal cancer syndromes was previously limited to single gene tests; thus, only a very limited number of genes were tested, and rarely those infrequently mutated in colorectal cancer. Next-generation sequencing technologies have made it possible to sequencing panels of genes known and suspected to influence colorectal cancer susceptibility. METHODS: Targeted sequencing of 36 known or putative CRC susceptibility genes was conducted for 1231 CRC cases from five subsets: (1) Familial Colorectal Cancer Type X (n = 153); (2) CRC unselected by tumor immunohistochemical or microsatellite stability testing (n = 548); (3) young onset (age <50 years) (n = 333); (4) proficient mismatch repair (MMR) in cases diagnosed at ≥50 years (n = 68); and (5) deficient MMR CRCs with no germline mutations in MLH1, MSH2, MSH6, or PMS2 (n = 129)...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28943451/tubulin-binding-anticancer-polysulfides-induce-cell-death-via-mitotic-arrest-and-autophagic-interference-in-colorectal-cancer
#19
Esma Yagdi Efe, Aloran Mazumder, Jin-Young Lee, Anthoula Gaigneaux, Flavia Radogna, Muhammad Jawad Nasim, Christo Christov, Claus Jacob, Kyu-Won Kim, Mario Dicato, Patrick Chaimbault, Claudia Cerella, Marc Diederich
Polysulfanes show chemopreventive effects against gastrointestinal tumors. We identified diallyl tetrasulfide and its derivative, dibenzyl tetrasulfide (DBTTS), to be mitotic inhibitors and apoptosis inducers. Here, we translate their application in colorectal cancer (CRC). MALDI-TOF-MS analysis identified both compounds as reversible tubulin binders, validated by in cellulo α-tubulin degradation. BRAF(V600E)-mutated HT-29 cells were resistant to DBTTS, as evidenced by mitotic arrest for 48 h prior to apoptosis induction compared to KRAS(G12V)-mutated SW480/620 cells, which committed to death earlier...
September 21, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28939743/phospholipase-d1-inhibition-linked-to-upregulation-of-icat-blocks-colorectal-cancer-growth-hyperactivated-by-wnt-%C3%AE-catenin-and-pi3k-akt-signaling
#20
Dong Woo Kang, Bo Hui Lee, Young-Ah Suh, Yong-Seok Choi, Se Jin Jang, Yong-Man Kim, Kang-Yell Choi, Do Sik Min
PURPOSE: Dysregulated expression of PLD1 has emerged as a hallmark feature of colorectal cancer (CRC), which remains a major cause of mortality worldwide. Aberrant activation of Wnt/β-catenin signaling is a critical event in the development of CRC. Here, we investigated molecular crosstalk between the Wnt/β-catenin and PI3K/Akt pathways via ICAT, a negative regulator of Wnt/β-catenin signaling. We also explored the effect of PLD1 inhibition on growth of CRC hyperactivated by Wnt/β-catenin and PI3K/Akt signaling...
September 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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