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Young colorectal cancer

Kamolyut Lapumnuaypol, Ejaz Mahmood, Wikrom Chaiwatcharayut, Maria V Bandres, Abhinav Goyal, Djeneba A Djibo, Andrew Tiu
PURPOSE: Colorectal cancer (CRC) is the third most common cancer in the USA, and the incidence in young adults has been increasing over the past decade. We studied the clinical characteristics and presentations of CRC in young African American (AA) adults because available data on how age and ethnicity influence its pattern of presentation is limited. PATIENTS AND METHODS: We conducted a retrospective study of 109 young adults (75 African Americans) below 50 years, who were diagnosed with CRC between 1 January 1997 and 31 December 2016...
July 16, 2018: European Journal of Gastroenterology & Hepatology
Alberto Puccini, Heinz-Josef Lenz, John L Marshall, David Arguello, Derek Raghavan, W Michael Korn, Benjamin A Weinberg, Kelsey Poorman, Arielle L Heeke, Philip A Philip, Anthony F Shields, Richard M Goldberg, Mohamed E Salem
BACKGROUND: The incidence of colorectal cancer (CRC) in younger patients is rising, mostly due to tumors in the descending colon and rectum. Therefore, we aimed to explore the molecular differences of left-sided CRC between younger (≤45 years) and older patients (≥65). SUBJECTS, MATERIALS, AND METHODS: In total, 1,126 CRC tumor samples from the splenic flexure to (and including) the rectum were examined by next-generation sequencing (NGS), immunohistochemistry, and in situ hybridization...
July 17, 2018: Oncologist
Bo Gun Jang, Hye Sung Kim, Weon Young Chang, Jung Mo Bae, Gyeong Hoon Kang
Background: A receptor tyrosine kinase for ephrin ligands, EPHB2, is expressed in normal colorectal tissues and colorectal cancers (CRCs). The aim of this study was to investigate EPHB2 expression over CRC progression and determine its prognostic significance in CRC. Materials and Methods: To measure EPHB2 mRNA and protein expression, real-time PCR and immunohistochemistry were performed in 32 fresh-frozen and 567 formalin-fixed paraffin-embedded CRC samples, respectively...
July 18, 2018: Journal of Pathology and Translational Medicine
David H Murray, Erin L Symonds, Graeme P Young, Susan Byrne, Philippa Rabbitt, Amitesh Roy, Kathryn Cornthwaite, Christos S Karapetis, Susanne K Pedersen
PURPOSE: Methylation in IKZF1 and BCAT1 are common events in colorectal cancer (CRC). They are often detected in blood as circulating tumor DNA (ctDNA) at diagnosis and disappear after surgery in most CRC patients. A prospective study was conducted to determine the relationship between detection of these markers following surgery and risk for residual disease and for recurrence. METHODS: ctDNA status with methylated BCAT1 and IKZF1 was determined within 12 months of surgical resection of CRC, and was related to presence of or risk for residual disease (margins involved, metastases present or nature of node involvement), and to recurrence-free survival...
July 10, 2018: Journal of Cancer Research and Clinical Oncology
M E Joosse, M A Aardoom, P Kemos, D Turner, D C Wilson, S Koletzko, J Martin-de-Carpi, U L Fagerberg, C Spray, C Tzivinikos, M Sladek, R Shaoul, E Roma-Giannikou, J Bronsky, D E Serban, F M Ruemmele, H Garnier-Lengline, G Veres, I Hojsak, K L Kolho, I H Davies, M Aloi, P Lionetti, S Hussey, G Veereman, C P Braegger, E Trindade, A V Wewer, A C Hauer, A C H de Vries, R Sigall Boneh, C Sarbagili Shabat, A Levine, L de Ridder
BACKGROUND: Risk benefit strategies in managing inflammatory bowel diseases (IBD) are dependent upon understanding the risks of uncontrolled inflammation vs those of treatments. Malignancy and mortality in IBD have been associated with disease-related inflammation and immune suppression, but data are limited due to their rare occurrence. AIM: To identify and describe the most common causes of mortality, types of cancer and previous or current therapy among children and young adults with paediatric-onset IBD...
July 8, 2018: Alimentary Pharmacology & Therapeutics
Young-Rock Hong, Kalyani B Sonawane, Derek R Holcomb, Ashish A Deshmukh
Despite the significant increase in the risk of colorectal cancer (CRC), one-third of individuals with diabetes who met screening recommendations, reported not being up-to-date on CRC screening in the United States. We determined the means through which individuals with type 2 diabetes (T2DM) learned about diabetes care; we further examined their associations with CRC screening uptake. This was a retrospective study of US adults aged 50-75 years diagnosed with T2DM (sample n  = 5595, representing 14,724,933 Americans)...
September 2018: Preventive Medicine Reports
Bo Ram Kim, Yoon A Jeong, Yoo Jin Na, Seong Hye Park, Min Jee Jo, Jung Lim Kim, Soyeon Jeong, Suk-Young Lee, Hong Jun Kim, Sang Cheul Oh, Dae-Hee Lee
[This corrects the article DOI: 10.18632/oncotarget.21882.].
June 19, 2018: Oncotarget
Eui Joo Kim, Kwang An Kwon, Young Eun Lee, Ju Hyun Kim, Se-Hee Kim, Jung Ho Kim
Background: The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which KRGE regulates EMT of CRC in hypoxic conditions. Methods: Human CRC cell lines HT29 and HCT116 were incubated under hypoxic (1% oxygen) and normoxic (21% oxygen) conditions...
July 2018: Journal of Ginseng Research
Yong Ma, Yiqian Luo, Nan Lin, Yongzhu Lv, Yang Zhou, Bing Li, Kunna Han, Song Jiang, Jianjun Gao
Background: Mucinous adenocarcinoma (MC) is a special kind of colorectal adenocarcinoma that occurs more frequently in young patients and females, but the prognostic effect of lymph nodes in MC patients is unclear. This population-based study was conducted to analyze the prognostic value of the number of lymph nodes examined in different stages of colorectal MC. Methods: We included 17,001 MC patients from the Surveillance, Epidemiology, and End Results program database between 2003 and 2013, of which 12,812 (75%) had >12 lymph nodes examined...
2018: OncoTargets and Therapy
Sang Mun Bae, Soo Jung Park, Myoungeun Choi, Miyeoun Song, Young Eun Cho, Eun-Ju Do, Yeon-Mi Ryu, Sunha Park, Byung-Heon Lee, Sang-Wook Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Suk-Kyun Yang, Jinmyoung Joo, Sang-Yeob Kim, Seung-Jae Myung
Accurate and timely visualization of apoptotic status in response to radiation is necessary for deciding whether to continue radiation or change to another mode of treatment. This is especially critical in patients with colorectal cancer, which requires a delicate combination of surgery, radiation, and chemotherapy in order to achieve optimal outcome. In this study, we investigated the potential of phosphatidylserine-recognizing peptide 1 (PSP1) as an apoptosis-targeting probe, which identifies phosphatidylserine on cell surfaces...
July 4, 2018: Translational Oncology
Gemma K Collett, Ivana Durcinoska, Nicole M Rankin, Prunella Blinman, David J Barnes, Cleola Anderiesz, Jane M Young
PURPOSE: Improving the coordination of care for people with lung cancer is a health priority. This study aimed to tailor an existing care coordination survey for a lung cancer population, investigate coordination experiences for patients who had received hospital-based treatment and identify any factors that may be associated with poor care coordination. METHODS: We conducted a cross-sectional survey of lung patients within two tertiary hospitals in Sydney, Australia...
July 6, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Aeris Jane D Nacion, Youn Young Park, Seung Yoon Yang, Nam Kyu Kim
Despite innovative advancements, the management of distally located rectal cancer (RC) remains a formidable endeavor. The critical location of the tumor predisposes it to a circumferential resection margin that tends to involve the sphincters and surrounding organs, pelvic lymph node metastasis, and anastomotic complications. In this regard, colorectal surgeons should be aware of issues beyond the performance of total mesorectal excision (TME). For decades, abdominoperineal resection had been the standard of care for low-lying RC; however, its association with high rates of tumor recurrence, tumor perforation, and poorer survival has stimulated the development of novel surgical techniques and modifications, such as extralevator abdominoperineal excision...
August 2018: Yonsei Medical Journal
Ye-Lim Park, Hwang-Phill Kim, Young-Won Cho, Dong-Wook Min, Seul-Ki Cheon, Yoo Joo Lim, Sang-Hyun Song, Sung Jin Kim, Sae-Won Han, Kyu Joo Park, Tae-You Kim
PIK3CA is a frequently mutated gene in cancer, including about ∼15 to 20% of colorectal cancers (CRC). PIK3CA mutations lead to activation of the PI3K/AKT/mTOR signaling pathway, which plays pivotal roles in tumorigenesis. Here, we investigated the mechanism of resistance of PIK3CA-mutant CRC cell lines to gedatolisib, a dual PI3K/mTOR inhibitor. Out of a panel of 29 CRC cell lines, we identified 7 harboring one or more PIK3CA mutations; of these, 5 and 2 were found to be sensitive and resistant to gedatolisib, respectively...
July 6, 2018: International Journal of Cancer. Journal International du Cancer
Brittany M Bernardo, Amy L Gross, Gregory Young, Ryan Baltic, Sarah Reisinger, William J Blot, Electra Diane Paskett
Background: Despite declining colorectal cancer (CRC) incidence and mortality rates in the U.S., significant geographic and racial disparities in CRC death rates remain. Differences in guideline-concordant CRC screening rates may explain some of these disparities. We aim to assess individual and neighborhood-level predictors of guideline-concordant CRC screening within two cohorts of individuals located within CRC mortality geographic hotspot regions in the U.S. Methods: A total of 36,901 participants from the Southern Community Cohort Study and 4,491 participants from the Ohio Appalachia CRC screening study were included in this study...
2018: Frontiers in Oncology
Noémi Gede, Diána Reményi Kiss, István Kiss
BACKGROUND: This study aims to survey the level of awareness of colorectal cancer and screening and to identify sources of information among the population under investigation. METHODS: A cross-sectional study was conducted among 1150 adults between the ages of 40 and 70 using quota sampling. Data were collected through self-made questionnaires to be completed by respondents. RESULTS: 32.7% of the participants correctly identified the recommended beginning of colorectal cancer screening, these participants were more likely to see their physician more frequently in the past years than those answering to the qusetion incorrectly (p = 0...
June 30, 2018: BMC Family Practice
Matthew D Rutter, Iosif Beintaris, Roland Valori, Han Mo Chiu, Douglas A Corley, Miriam Cuatrecasas, Evelien Dekker, Anna Forsberg, Jola Gore-Booth, Ulrike Haug, Michal F Kaminski, Takahisa Matsuda, Gerrit A Meijer, Eva Morris, Andrew A Plumb, Linda Rabeneck, Douglas J Robertson, Robert E Schoen, Harminder Singh, Jill Tinmouth, Graeme P Young, Silvia Sanduleanu
BACKGROUND & AIMS: Colonoscopy examination does not always detect colorectal cancer (CRC)- some patients develop CRC after negative findings from an examination. When this occurs before the next recommended examination, it is called interval cancer. From a colonoscopy quality assurance perspective, that term is too restrictive, so the term post-colonoscopy colorectal cancer (PCCRC) was created in 2010. However, PCCRC definitions and methods for calculating rates vary among studies, making it impossible to compare results...
June 26, 2018: Gastroenterology
Eun-Young Ahn, You Jeong Lee, Seo Young Choi, A-Rang Im, Yeong Shik Kim, Youmie Park
Skate (Dipturus chilensis) cartilage extract was utilized as a green reducing agent for the synthesis of spherical gold nanoparticles with an average size of 16.7 ± 0.2 nm. The gold nanoparticle solution showed a surface plasmon resonance at 543 nm with a wine-red colour. A strong X-ray diffraction pattern and clear lattice structure in high-resolution transmission electron microscopy indicated a face-centred cubic structure of the gold nanoparticles. The gold nanoparticles retained excellent colloidal stability...
June 29, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Shamar Young, Jafar Golzarian
One area which has emerged as an important factor for predicting molecular profile and treatment outcomes in metastatic colorectal cancer (mCRC) is primary tumor location. The importance of molecular characteristics of colorectal cancer has been firmly established in terms of prognosis and treatment algorithms for many years. Recent studies have also suggested that molecular profiles are important in locoregional therapies as well, with some data suggesting changes in treatment algorithms based on tumor location...
June 26, 2018: Cardiovascular and Interventional Radiology
Erin L Young, Bryony A Thompson, Deborah W Neklason, Matthew A Firpo, Theresa Werner, Russell Bell, Justin Berger, Alison Fraser, Amanda Gammon, Cathryn Koptiuch, Wendy K Kohlmann, Leigh Neumayer, David E Goldgar, Sean J Mulvihill, Lisa A Cannon-Albright, Sean V Tavtigian
BACKGROUND: Genes associated with hereditary breast and ovarian cancer (HBOC) and colorectal cancer (CRC) predisposition have been shown to play a role in pancreatic cancer susceptibility. Growing evidence suggests that pancreatic cancer may be useful as a sentinel cancer to identify families that could benefit from HBOC or CRC surveillance, but to date pancreatic cancer is only considered an indication for genetic testing in the context of additional family history. METHODS: Preliminary data generated at the Huntsman Cancer Hospital (HCH) included variants identified on a custom 34-gene panel or 59-gene panel including both known HBOC and CRC genes for respective sets of 66 and 147 pancreatic cancer cases, unselected for family history...
June 27, 2018: BMC Cancer
Maryam Esghaei, Hadi Ghaffari, Bahman Rahimi Esboei, Zienab Ebrahimi Tapeh, Farah Bokharaei Salim, Manijeh Motevalian
Background: Colorectal cancer (CRC) is widespread across the world. While conventional anticancer treatments can help the affected patients, cells of vital organs such as the kidney, lungs, bladder and nervous system may suffer from side effects of chemotherapeutic drugs, so that it is necessary to search for alternatives. From ancient times, attention has focused on medicinal plants and natural products. In the current work, Camellia sinensis, whose leaves are used to produce green tea was evaluated for anticancer effects in cell culture...
June 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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