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https://www.readbyqxmd.com/read/30241382/zkscan3-upregulation-and-its-poor-clinical-outcome-in-uterine-cervical-cancer
#1
Sun Lee, Young-Eun Cho, Joo-Young Kim, Jae-Hoon Park
Zinc finger with KRAB and SCAN domain 3 (ZKSCAN3) upregulates genes encoding proteins involved in cell differentiation, proliferation and apoptosis. ZKSCAN3 has been reported to be overexpressed in several human cancers such as colorectal cancer and prostate cancer and is proposed as a candidate oncoprotein. However, the molecular mechanism by which ZKSCAN3 participates in carcinogenesis is largely unknown. Here, we evaluated ZKSCAN3 expression in uterine cervical cancers (CC) by immunohistochemistry using formalin-fixed, paraffin-embedded tissues from 126 biopsy samples from 126 patients...
September 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30239394/secondary-breast-ovarian-and-uterine-cancers-after-colorectal-cancer-a-nationwide-population-based-cohort-study-in-korea
#2
Dong Woo Shin, Yoon Jin Choi, Hyun Soo Kim, Kyung-Do Han, Hyuk Yoon, Young Soo Park, Nayoung Kim, Dong Ho Lee
BACKGROUND: The risk of a second primary cancer has increased along with the increasing life expectancies of colorectal cancer survivors. OBJECTIVE: We aimed to evaluate the incidence rate and risk factors of breast and gynecological (ovarian, uterine cervix/corpus) cancers among female colorectal cancer survivors. DESIGN: This is a retrospective population-based cohort study. SETTINGS: This study used data from the National Health Insurance Corporation of Korea...
September 19, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/30230679/chemotherapy-and-biologic-use-in-the-routine-management-of-metastatic-colorectal-cancer-in-australia-is-clinical-practice-following-the-evidence
#3
Christine Semira, Hui-Li Wong, Kathryn Field, Margaret Lee, Belinda Lee, Louise Nott, Jeremy Shapiro, Rachel Wong, Jeanne Tie, Ben Tran, Gary Richardson, Allan Zimet, Lara Lipton, Babak Tamjid, Matthew Burge, Brigette Ma, Julie Johns, Michael Harold, Peter Gibbs
BACKGROUND: Emerging evidence on the optimal use of chemotherapy and biologics in patients with metastatic colorectal cancer (mCRC) should impact management in routine care. Recent studies have demonstrated benefits for initial triplet chemotherapy (FOLFOXIRI) and for initial treatment with an epidermal growth factor receptor inhibitor (EGFRi) in patients with a RAS wild type tumour and a left-sided primary. AIM: To explore evolving patterns of mCRC care over time in Australia...
September 19, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/30224412/netrin-1-dcc-mediated-plc%C3%AE-1-activation-is-required-for-axon-guidance-and-brain-structure-development
#4
Du-Seock Kang, Yong Ryoul Yang, Cheol Lee, BumWoo Park, Kwang Il Park, Jeong Kon Seo, Young Kyo Seo, HyungJoon Cho, Cocco Lucio, Pann-Ghill Suh
Coordinated expression of guidance molecules and their signal transduction are critical for correct brain wiring. Previous studies have shown that phospholipase C gamma1 (PLCγ1), a signal transducer of receptor tyrosine kinases, plays a specific role in the regulation of neuronal cell morphology and motility in vitro However, several questions remain regarding the extracellular stimulus that triggers PLCγ1 signaling and the exact role PLCγ1 plays in nervous system development. Here, we demonstrate that PLCγ1 mediates axonal guidance through a netrin-1/deleted in colorectal cancer (DCC) complex...
September 17, 2018: EMBO Reports
https://www.readbyqxmd.com/read/30221676/lipocalin-2-inversely-regulates-trail-sensitivity-through-p38-mapk-mediated-dr5-regulation-in-colorectal-cancer
#5
Se-Lim Kim, In Suk Min, Young Ran Park, Soo Teik Lee, Sang-Wook Kim
TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis through death receptors (DRs)4 and/or 5 expressed on the cell surface. Multiple clinical trials are underway to evaluate the antitumor activity of recombinant human TRAIL and agonistic antibodies to DR4 or DR5. However, their therapeutic potential is limited by the high frequency of cancer resistance. In this study, we provide evidence demonstrating the role of lipocalin 2 (LCN2) in the TRAIL-mediated apoptosis of human colorectal cancer (CRC)...
September 14, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30220672/colorectal-surgery-in-elderly-population
#6
Marek Zawadzki, Małgorzata Krzystek-Korpacka, Marek Rząca, Roman Czarnecki, Zbigniew Obuszko, Wojciech Witkiewicz
INTRODUCTION: With the rising number of elderly patients and increasing incidence of colorectal cancer, management of geriatric patients has become the forefront of colorectal surgery. OBJECTIVES: This study aimed to investigate the short-term surgical outcomes following colorectal resection in elderly patients. MATERIALS AND METHODS: A total of 464 patients who underwent surgical resection for colorectal tumor between 2013 and 2017 were included...
June 13, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/30210625/ncoa4-ret-fusion-in-colorectal-cancer-therapeutic-challenge-using-patient-derived-tumor-cell-lines
#7
Sun Young Kim, Seiyoon Oh Oh, Kyung Kim, Jeeyun Lee, SoYoung Kang, Kyoung-Mee Kim, WooYong Lee, Seung Tae Kim, Dohyun Nam Nam
The RET fusion is considered as the potential novel target in solid tumors. However, RET fusion is not well yet identified in colorectal cancer (CRC), and the effect of RET kinase inhibitor is also not evaluated in CRC with RET fusion. We established patient-derived tumor cells (PDCs) with RET fusion from recurrent brain metastatic lesion that newly appeared during the surveillance for stage III CRC patient. To investigate therapeutic options to CRC patient with a RET fusion, we performed cell viability assays using the PDCs...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/30210226/increased-incidence-of-chemoport-related-thrombosis-in-patients-with-colorectal-cancer-receiving-bevacizumab-a-single-institutional-experience
#8
Jwa Hoon Kim, Jeong Eun Kim, Yong Sang Hong, Sun Young Kim, Kyu-Pyo Kim, Ki Eun Choi, Ji Hoon Shin, Tae Won Kim
Objective: Chemoport-related thrombosis (CRT) is a serious complication that causes morbidities and interrupts administration of intravenous cancer therapy. We investigated the incidence and risk of CRT in colorectal cancer (CRC) patients treated with bevacizumab (BEV). Methods: We retrospectively reviewed 1,534 CRC patients who received chemotherapy with or without BEV using a chemoport between 2014 and 2016. Results: The participants had a median age of 58 (18-85) years, and 60...
August 2018: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/30208684/characteristics-and-survival-of-korean-patients-with-colorectal-cancer-based-on-data-from-the-korea-central-cancer-registry-data
#9
Hyuk Hur, Chang-Mo Oh, Young-Joo Won, Jae Hwan Oh, Nam Kyu Kim
PURPOSE: The incidence of colorectal cancer (CRC) in Korea has increased remarkably during the past few decades. The present study investigated the characteristics and survival of patients with CRC in Korea as a function of time, tumor distribution, stage, sex, and age. METHODS: We retrieved clinical data on 326,712 CRC patients diagnosed between 1996 and 2015 from the Korea Central Cancer Registry. The incidence and the 5-year relative survival rates were compared across time period, tumor distribution, stage, sex, and age group...
August 2018: Annals of Coloproctology
https://www.readbyqxmd.com/read/30196424/familial-cancer-clustering-in-patients-with-prolactinoma
#10
Sandra Pekic, Ivan Soldatovic, Dragana Miljic, Marko Stojanovic, Mirjana Doknic, Milan Petakov, Vera Popovic
People are at higher risk for malignancy as they get older or have a strong family history of cancer. This study aims to collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in outpatient clinic from years 2005-2017. Overall, 46.6% of 1062 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas which was significantly higher than in families of patients with non-functioning pituitary adenomas (NFPA) (10...
September 8, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/30185973/quantitative-proteomic-analysis-of-2d-and-3d-cultured-colorectal-cancer-cells-profiling-of-tankyrase-inhibitor-xav939-induced-proteome
#11
Young Eun Kim, Hyo Jin Jeon, Dahee Kim, Sun Young Lee, Ki Young Kim, Jongki Hong, Pil Jae Maeng, Kwang-Rok Kim, Dukjin Kang
Recently there has been a growing interest in three-dimensional (3D) cell culture systems for drug discovery and development. These 3D culture systems better represent the in vivo cellular environment compared to two-dimensional (2D) cell culture, thereby providing more physiologically reliable information on drug screening and testing. Here we present the quantitative profiling of a drug-induced proteome in 2D- and 3D-cultured colorectal cancer SW480 cells using 2D nanoflow liquid chromatography-tandem mass spectrometry (2D-nLC-MS/MS) integrated with isobaric tags for relative and absolute quantitation (iTRAQ)...
September 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30184208/effects-of-screening-and-universal-healthcare-on-long-term-colorectal-cancer-mortality
#12
Yi-Chia Lee, Chen-Yang Hsu, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Shu-Lin Chuang, Wen-Feng Hsu, Tsung-Hsien Chiang, Han-Mo Chiu, Ming-Shiang Wu, Hsiu-Hsi Chen
Background: To evaluate the time trends of colorectal cancer (CRC) affected by a Nationwide Colorectal Cancer Screening (NCCS) programme with biennial faecal immunochemical testing (FIT) and Nationwide Healthcare Insurance (NHI). Methods: Data from the national registries on cancer and death in Taiwan were separated into years 1984-1993, 1994-2003 and 2004-2013 based on the implementations of NHI (starting 1995) and NCCS (starting 2004). The adult population was divided into three age groups (young, 30-49; middle-aged, 50-69; and old, 70-84 years); only the middle-aged were eligible for NCCS...
September 3, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/30180112/an-examination-of-multilevel-factors-influencing-colorectal-cancer-screening-in-primary-care-accountable-care-organization-settings-a-mixed-methods-study
#13
Jungyoon Kim, Hongmei Wang, Lufei Young, Tzeyu L Michaud, Mohammad Siahpush, Paraskevi A Farazi, Li-Wu Chen
OBJECTIVE: To identify patient, provider, and delivery system-level factors associated with colorectal cancer (CRC) screening and validate findings across multiple data sets. DESIGN: A concurrent mixed-methods design using electronic health records, provider survey, and provider interview. SETTING: Eight primary care accountable care organization clinics in Nebraska. MEASURES: Patients' demographic/social characteristics, health utilization behaviors, and perceptions toward CRC screening; provider demographics and practice patterns; and clinics' delivery systems (eg, reminder system)...
August 31, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/30170441/colonoscopic-withdrawal-time-and-adenoma-detection-in-the-right-colon
#14
Gee Young Yun, Hyuk Soo Eun, Ju Seok Kim, Jong Seok Joo, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Shorter colonoscopic withdrawal time (CWT) has been associated with lower adenoma detection rate (ADR), which can increase the risk of interval colorectal cancer (ICC) that commonly arises in the right colon (RC). Therefore, a better ADR in the RC could decrease the incidence of ICC. We analyzed the relationship between CWT and ADR in the RC and entire colon.We retrospectively reviewed the patients who had undergone screening colonoscopy at Chungnam National University Hospital between March 2015 and February 2016...
August 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30170328/impact-of-peritoneal-carcinomatosis-on-clinical-outcomes-of-patients-receiving-self-expandable-metal-stents-for-malignant-colorectal-obstruction
#15
Jae Jun Park, Kwangwon Rhee, Jin Young Yoon, Soo Jung Park, Joo Hee Kim, Jie-Hyun Kim, Young Hoon Youn, Tae Il Kim, Hyojin Park, Won Ho Kim, Jae Hee Cheon
BACKGROUND:  Peritoneal carcinomatosis can influence clinical outcomes of patients receiving self-expandable metal stents (SEMS) for malignant colorectal obstruction, but data regarding this issue are sparse. We analyzed the clinical outcomes of post-SEMS insertion for malignant colorectal obstruction based on carcinomatosis status. METHODS:  Stent- and patient-related clinical outcomes were compared for carcinomatosis status in a retrospective review involving 323 consecutive patients (colorectal cancer 198 patients; extracolonic malignancy 125 patients) who underwent palliative SEMS placement for malignant colorectal obstruction from January 2005 to March 2012...
August 31, 2018: Endoscopy
https://www.readbyqxmd.com/read/30165046/decrease-in-incidence-of-young-onset-colorectal-cancer-before-recent-increase
#16
Caitlin C Murphy, Amit G Singal, John A Baron, Robert S Sandler
The increasing incidence of colorectal cancer (CRC) in younger adults (age <50 years) has been widely reported. Using data from the Surveillance, Epidemiology, and End Results Program, we young-onset CRC incidence rates decreased from 1975 through about 1990. Decreases were more prominent in the colon, a contrast with more recent increases in rectal cancer. Incidence rates subsequently increased, differing by time period and 5-year age group. This inflection point is consistent with a birth cohort effect and points to early life exposures - accumulated throughout the life course - that may increase cancer risk...
August 27, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30151676/prognostic-impact-of-perineural-invasion-in-rectal-cancer-after-neoadjuvant-chemoradiotherapy
#17
Chang Hyun Kim, Seung-Seop Yeom, Soo Young Lee, Hyeong Rok Kim, Young Jin Kim, Kyung Hwa Lee, Jae Hyuk Lee
BACKGROUND: Perineural invasion (PNI) has emerged as an important factor related to colorectal cancer spread; however, the impact of neoadjuvant chemoradiotherapy (nCRT) on PNI remains unclear. Herein, we investigated the prognostic value of PNI, along with lymphovascular invasion (LVI), in rectal cancer patients treated with nCRT. METHODS: This single-center observational study of pathologic variables, including PNI and LVI, analyzed 1411 invasive rectal cancer patients (965 and 446 patients treated with primary resection and nCRT, respectively)...
August 27, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/30151276/unresectable-metastatic-colorectal-cancer-patient-cured-with-cetuximab-based-chemotherapy-a-case-report-with-new-molecular-insights
#18
Romain Cohen, Marine Sroussi, Camilla Pilati, Sidney Houry, Pierre Laurent-Puig, Thierry André
Here we report the case of a 20-year-old patient who was diagnosed in 2002 with a metastatic colorectal cancer (CRC). He achieved a complete response under cetuximab-based therapy and remains without disease recurrence until now while chemotherapy was discontinued in 2009. The tumor exhibited high level of epidermal growth factor receptor ( EGFR ) amplification, no mutation in KRAS , NRAS or BRAF genes and a microsatellite-stable (MSS) phenotype. Intriguingly this young patient was carrying a monoallelic germline mutation of MUTYH that was associated with an inactivation of the second allele by loss of heterozygosity on tumor DNA...
August 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/30150667/vitamin-d-receptor-foki-polymorphism-and-the-risks-of-colorectal-cancer-inflammatory-bowel-disease-and-colorectal-adenoma
#19
Young Ae Cho, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Based on an inverse association between vitamin D levels and the risks of colorectal diseases, a functional start codon polymorphism in the vitamin D receptor (VDR) gene is speculated to affect the risks for these diseases. To validate this hypothesis, we first conducted a case-control study of 695 colorectal cancer patients and 1,397 controls. The association of VDR FokI polymorphism with colorectal cancer risk was analyzed using a logistic regression model. In the present case-control study, compared to the F allele, the f allele seemed to be associated with lower risks of colon cancer and advanced colorectal cancer...
August 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30149993/competing-risks-analysis-of-the-effect-of-local-residual-tumour-on-recurrence-and-cancer-specific-death-after-resection-of-colorectal-cancer-implications-for-staging
#20
Ronald C Newland, Charles Chan, Pierre H Chapuis, Anil Keshava, Matthew J F X Rickard, Christopher J Young, Owen F Dent
The pTNM staging system for colorectal cancer (CRC) is not entirely effective in discriminating between potentially curative and non-curative resections because it does not account for local residual tumour in patients with stages I, II or III. This study aimed to evaluate the prognostic importance of histologically verified tumour in any line of resection of the bowel resection specimen (TLR) in relation to pTNM stages and to demonstrate how TLR may be integrated into pTNM staging. Information on patients in the period 1995 to 2010 with complete follow-up to the end of 2015 was extracted from a prospective database of CRC resections...
August 24, 2018: Pathology
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