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K Wiggins, B Eastmond, B W Alto
Mayaro virus (MAYV) is an emerging mosquito-borne arbovirus present in Central and South America that causes arthralgia and febrile illness. Domestic mosquitoes Aedes aegypti (Diptera: Culicidae) and Aedes albopictus are potential vectors of MAYV that may allow for transmission to humans in urban settings. The present paper assesses susceptibility to infection, disseminated infection and transmission potential in Florida Ae. aegypti and Ae. albopictus for MAYV. Oral infection was significantly higher in Ae...
July 13, 2018: Medical and Veterinary Entomology
Niko Paalanne, Aleksi Husso, Jarmo Salo, Oskari Pieviläinen, Mysore V Tejesvi, Pirjo Koivusaari, Anna Maria Pirttilä, Tytti Pokka, Sampo Mattila, Juha Jyrkäs, Ari Turpeinen, Matti Uhari, Marjo Renko, Terhi Tapiainen
As urinary tract infection (UTI) pathogens originate from the gut, we hypothesized that the gut environment reflected by intestinal microbiome influences the risk of UTI. Our prospective case-control study compared the intestinal microbiomes of 37 children with a febrile UTI with those of 69 healthy children. We sequenced the regions of the bacterial 16S rRNA gene and used the LefSe algorithm to calculate the size of the linear discriminant analysis (LDA) effect. We measured fecal lactoferrin and iron concentrations and quantitative PCR for Escherichia coli...
July 13, 2018: European Journal of Clinical Microbiology & Infectious Diseases
A-S Bertrand, M Fondain, P Rullier, C Fontaine, B Guillot
INTRODUCTION: Haemophagocytic syndrome (HS) is a rare disease with a severe prognosis that is defined by clinical, laboratory and histopathological criteria. Infections represent the classical cause of HS. HS secondary to Mediterranean spotted fever (MSF) is rare with only a few cases being reported in the literature. OBSERVATIONS: We report two cases of HS secondary to MSF in 2 men aged 77 and 63 years presenting a febrile maculo-purpuric eruption with inoculation ulcer associated with laboratory abnormalities (cytopenia, elevated ferritin, hypertriglyceridaemia)...
July 10, 2018: Annales de Dermatologie et de Vénéréologie
Wenbin Mo, Xiaoxue Wang, Yue Wang, Yan Li, Rui Zhang
Sweet's syndrome (SS), also known as acute febrile neutrophilic dermatosis is often associated with a hematological malignancy, especially acute myeloid leukemia (AML) and myeloid dysplasia syndrome. Histopathologically, SS is characterized by diffuse infiltrates in the upper dermis, predominantly consisting of mature neutrophils. The origin of neutrophils invading the skin remains unknown. Herein, we report a patient with concurrent acute monoblastic leukemia and SS who initially presented with discrete erythematous papules and nodules on the neck...
October 2018: Cancer Genetics
Mariana Kikuti, Laura B Tauro, Patrícia S S Moreira, Gúbio S Campos, Igor A D Paploski, Scott C Weaver, Mitermayer G Reis, Uriel Kitron, Guilherme S Ribeiro
BACKGROUND: Serologic detection of Zika virus (ZIKV) infections is challenging because of antigenic similarities among flaviviruses. OBJECTIVE: To evaluate the sensitivity and specificity of commercial ZIKV IgM and IgG enzyme-linked immunoassay (ELISA) kits. METHODS: We used sera from febrile patients with RT-PCR-confirmed ZIKV infection to determine sensitivity and sera from RT-PCR-confirmed dengue cases and blood donors, both of which were collected before ZIKV epidemics in Brazil (2009-2011 and 2013, respectively) to determine specificity...
July 13, 2018: Virology Journal
Vaneza Tique, Salim Mattar, Jorge Miranda, Misael Oviedo, Angel Noda, Eney Montes, Virginia Rodriguez
Objective: To describe and analyze the clinical and epidemiological status in 28 confirmed cases of human leptospirosis at the main public hospital of Cordoba. Methods: Between 2012 and 2013, we conducted an active surveillance at the main hospital of Cordoba to establish the etiologic diagnosis of the undifferentiated tropical febrile illness (UTFI) cases. UTFI is defined as a fever without an infection focus in the initial physical examination or in basic laboratory tests...
2018: BioMed Research International
D Buonsenso, S Cristaldi, A Reale, I Tarissi de Jacobis, L Granata, A Marchesi
Kawasaki disease (KD) is an acute, self-limited, inflammatory disease affecting medium-sized arteries and particularly the coronary arteries in about 25% of untreated cases. KD is a clinical diagnosis based on the presence of ≥5 days of fever and the presence of ≥4 of the 5 principal clinical criteria. We described, for the first time to our knowledge, a case of a very early development (on day 1) of typical KD with transient coronary involvement, diagnosed on day 2 of disease and treated with aspirin and steroids on day 3, with complete resolution of clinical signs and coronary involvement...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Sakaorat Lertjuthaporn, Ladawan Khowawisetsut, Rassamon Keawvichit, Korakot Polsrila, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Premrutai Thitilertdecha, Nattawat Onlamoon, Aftab A Ansari, Kovit Pattanapanyasat
Dengue virus (DENV) is the most prevalent arthropod-borne viral disease in humans. DENV causes a spectrum of illness ranging from mild to potentially severe complications. Dendritic cells (DCs) play a critical role in initiating and regulating highly effective antiviral immune response that include linking innate and adaptive immune responses. This study was conducted to comparatively characterize in detail the relative proportion, phenotypic changes, and maturation profile of subsets of both myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in children with dengue fever (DF), dengue hemorrhagic fever (DHF) and for purposes of control healthy individuals...
2018: PloS One
Kumaran Vadivel, Ramamurthy Mageshbabu, Sathish Sankar, Amita Jain, Vivekanandan Perumal, Padma Srikanth, Ghosh Asit Ranjan, Aravindan Nair, Eric A F Simoes, Balaji Nandagopal, Gopalan Sridharan
Background & objectives: Human parvovirus B19V (B19V) is known to be associated with erythema infectiosum commonly in children, aplastic crisis, especially in persons with underlying haemolytic disorders, hydrops fetalis in pregnancies and arthritis. This cross-sectional study was aimed to determine the presence of B19V infection in childhood febrile illnesses, association of B19V with arthropathies and in adult patients with end-stage renal disease (ESRD) on dialysis. The genetic diversity among the sequences was also analysed...
April 2018: Indian Journal of Medical Research
Michellen S de Carvalho, Andressa Z de Lara Pinto, Aquirya Pinheiro, Jorge S V Rodrigues, Fernando L Melo, Leonardo Assis da Silva, Bergmann M Ribeiro, Renata Dezengrini-Slhessarenko
BACKGROUND: High throughput sequencing (HTS) boosted the discovery of novel viruses and new variants of known viruses. Here we investigated the presence of viruses in 12 pools of sand flies captured in three climatic periods in RAPELD grids at Rio Claro, Chapada dos Guimarães and at Pirizal, North Pantanal, Mato Grosso State, Midwestern Brazil by HTS, viral isolation of a putative Phlebovirus positive pool in Vero cells, RT-PCR and transmission electron microscopy (TEM). RESULTS: One pool containing three Lutzomyia (Lutzomyia) longipalpis sand flies captured in the transitional climatic period in North Pantanal showed a tripartite genomic sequence of a putative novel Phlebovirus belonging to the phlebotomus fever serogroup...
July 11, 2018: Parasites & Vectors
Z Yang, T Y He, X D Zhao, J Yang
Objective: To investigate the clinical, inflammatory and genetic characteristics of cases with periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. Methods: Clinical and inflammatory manifestations and gene sequencing of 11 cases with PFAPA were retrospectively analyzed. Inflammatory markers including white blood cell (WBC) , C reactive protein (CRP) , and serum amyloid A (SAA) were compared between febrile period and intermittent period. Fifteen normal children were taken as healthy controls...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Q Zeng, Y H Zhang, X L Yang, J Zhang, A J Liu, X Y Liu, Y W Jiang, X R Wu
Objective: To summarize the phenotype of epileptic children with SCN2A mutations. Methods: Epileptic patients who were treated in the Pediatric Department of Peking University First Hospital from September 2006 to October 2017 and detected with SCN2A mutations by targeted next-generation sequencing were enrolled. Clinical manifestations of all patients were analyzed retrospectively. Results: A total of 21 patients (16 boys and 5 girls) with SCN2A mutations were collected. Twenty-one SCN2A mutations were identified...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Xin Luo, Xiang Yang, Jiexian Li, Ge Zou, Yufeng Lin, Guoqiang Qing, Ruilin Yang, Weixiang Yao, Xuying Ye
Discrimination between urosepsis and febrile urinary tract infections is important in therapeutic decision-making to indicate suitable treatments to avoid sepsis-related organ failure. Accurate diagnosis is time-consuming and susceptible to false-positive results. Moreover, patient responses to urosepsis are complex and varied. Therefore, this study aimed to develop a new, early diagnostic predictor that could discriminate between patients with urosepsis and those with febrile urinary tract infections using a combination of initial procalcitonin and albumin levels...
July 2018: Medicine (Baltimore)
Waheed Atilade Adegbiji, Gabriel Toye Olajide, Olawale Olubi, Adebayo AbdulAkeem Aluko, Anthony Oyebanji Olajuyin, Paul Adebisi Eletta, Abdulmajid Ibrahim Yahya
OBJECTIVES: Tinnitus is a commonly neglected otologic symptom among children in developing country. This study aimed at determining the prevalence, clinical characteristics, diagnosis and management of childhood tinnitus in a developing country. METHOD: This prospective hospital based study of patients' age 18 years and below with complaints of tinnitus was conducted in Ear, Nose and Throat Department of Ekiti state UniversityTeaching Hospital,Ado Ekiti,Nigeria between April 2016 to March 2018...
June 1, 2018: International Tinnitus Journal
Waheed Atilade Adegbiji, Gabriel Toye Olajide, Fatai Olatoke, Anthony Oyebanji Olajuyin, Olawale Olubi, Ahmed Ali, Paul Adebisi Eletta, Adebayo AbdulAkeem Aluko
OBJECTIVES: Preschool children hearing impairment is a common otologic diseases worldwide. The burdens of this preventable condition can be reduced in developing country. This study was carried out to determine the prevalence, diagnosis and management of hearing impairment among children less than 5 years seen in our center. METHOD: This was a prospective hospital based study of preschool children with complaints of hearing impairment in Ekiti state university teaching hospital, Nigeria...
June 1, 2018: International Tinnitus Journal
Debora Baroni, Cristiana Picco, Oscar Moran
Voltage-dependent sodium channels are responsible of the rising phase of the action potential in excitable cells. These integral membrane proteins are composed of a pore-forming α-subunit, and one or more auxiliary β subunits. Mutation p.Asp25Asn (D25N; c.73G > A) of the β1 subunit, coded by the gene SCN1B, has been reported in a patient with generalized epilepsy with febrile seizure plus type 1 (GEFS+). In HEK cells, the heterologous co-expression of D25N-β1 subunit with Nav1.2, Nav1.4 and Nav1.5 α subunits, representative of brain, skeletal muscle and heart voltage gated sodium channels, determines a reduced sodium channel functional expression and a negative shift of the activation and inactivation steady state curves...
July 10, 2018: Human Mutation
Mohammad M Obaidat, Amira A Roess
Background: There are no data available on dengue epidemiology in Jordan. This is the first study of the seroprevalence and risk factors of dengue virus (DENV) infection in Jordan. Methods: Sera samples from 892 apparently healthy individuals from all over Jordan were tested for DENV by enzyme-linked immunosorbent assay and a validated questionnaire was completed by all participants to identify and rank possible risk factors. Results: The seroprevalence was 24...
July 10, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
C Jones
This paper reappraises the role of medical clubs and societies in the production and consumption of knowledge in 18th-century Scotland and the wider North Atlantic world. It focuses on the Edinburgh Medical Society, founded in 1731 by Alexander Monro primus; and on the student Medical Society, founded in 1734 and constituted in 1737 as the Medical Society of Edinburgh, ultimately becoming the Royal Medical Society of Edinburgh in 1778. The paper examines how Monro, as editor of the transactions of the Edinburgh Medical Society, sought to adapt medical learning to a world of polite sociability; and how that world came under pressure in the student Medical Society, where prevailing orthodoxies, such as the system of Herman Boerhaave and, later, William Cullen, were challenged...
June 2018: Journal of the Royal College of Physicians of Edinburgh
Abdul Rauf, Sunit Singhi, Karthi Nallasamy, Mandeep Walia, Pallab Ray
Acute febrile illnesses (AFIs) in children from the developing world can have varying etiologies. Awareness of local epidemiology helps in prioritizing investigations and empiric treatment. This prospective study was carried out in a tertiary care center in North India, aiming to determine the burden, etiology, and outcome of AFI other than pneumonia and diarrhea in hospitalized children. A total of 613 consecutive children aged 3 months to 12 years with febrile illness of < 7 days during four selected months of 2014 representing different seasons were screened for eligibility...
July 9, 2018: American Journal of Tropical Medicine and Hygiene
Alexandra C Willcox, Matthew H Collins, Ramesh Jadi, Corinna Keeler, Jonathan B Parr, Dieudonné Mumba, Melchior Kashamuka, Antoinette Tshefu, Aravinda M de Silva, Steven R Meshnick
Flaviviruses such as Zika, dengue, and yellow fever cause epidemics throughout the tropics and account for substantial global morbidity and mortality. Although malaria and other vector-borne diseases have long been appreciated in Africa, flavivirus epidemiology is incompletely understood. Despite the existence of an effective vaccine, yellow fever continues to cause outbreaks and deaths, including at least 42 fatalities in the Democratic Republic of the Congo (DRC) in 2016. Here, we leveraged biospecimens collected as part of the nationally representative 2013-2014 Demographic and Health Survey in the DRC to examine serological evidence of flavivirus infection or vaccination in children aged 6 months to 5 years...
July 9, 2018: American Journal of Tropical Medicine and Hygiene
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