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Sumit D Bharadwaj, Rima R Sahay, Pragya D Yadav, Sara Dhanawade, Atanu Basu, Virendra K Meena, Suji George, Rekha Damle, Gajanan N Sapkal
We report 3 atypical rubella cases in a family cluster in India. The index case-patient showed only mild febrile illness, whereas the other 2 patients showed acute encephalitis and died of the disease. We confirmed rubella in the index and third cases using next-generation sequencing and IgM.
October 2018: Emerging Infectious Diseases
Morgan J Hennessey, Esther M Ellis, Mark J Delorey, Amanda J Panella, Olga I Kosoy, Hannah L Kirking, Grace D Appiah, Jin Qin, Alison J Basile, Leora R Feldstein, Brad J Biggerstaff, Robert S Lanciotti, Marc Fischer, J Erin Staples
When introduced into a naïve population, chikungunya virus generally spreads rapidly, causing large outbreaks of fever and severe polyarthralgia. We randomly selected households in the U.S. Virgin Islands (USVI) to estimate seroprevalence and symptomatic attack rate for chikungunya virus infection at approximately 1 year following the introduction of the virus. Eligible household members were administered a questionnaire and tested for chikungunya virus antibodies. Estimated proportions were calibrated to age and gender of the population...
September 17, 2018: American Journal of Tropical Medicine and Hygiene
Manuela Carugati, Helen L Zhang, Kajiru G Kilonzo, Michael J Maze, Venance P Maro, Matthew P Rubach, John A Crump
Febrile illnesses are a major cause of mortality in sub-Saharan Africa. Early identification of patients at increased risk of death may avert adverse outcomes. We aimed to independently evaluate the performance of the Modified Early Warning Score, quick Sequential Organ Failure Assessment (qSOFA) score, and Integrated Management of Adolescent and Adult Illness (IMAI) emergency signs and severity criteria to predict in-hospital mortality among a prospective cohort of febrile patients in Tanzania. We evaluated 419 patients aged ≥ 10 years in the period 2007-2008...
September 17, 2018: American Journal of Tropical Medicine and Hygiene
Tjede Funk, Karin Källander, Ayalkibet Abebe, Abreham Hailemariam, Helle Mölsted Alvesson, Tobias Alfvén
Different health-care management guidelines by the World Health Organization exist to help health workers in resource-limited settings treat patients. However, for children with unclassified fever and no danger signs, management guidelines are less clear and follow-up recommendations differ. Both "universal follow-up" for all children, irrespective of health status, and "conditional follow-up" only for children whose fever persists are recommended in different guidelines. It is unclear how feasible and acceptable these two different guidelines are among community health workers and caregivers of the sick child...
September 17, 2018: American Journal of Tropical Medicine and Hygiene
Mary Ellen Warner, David P Martin, Eli Muchtar, Juraj Sprung, Toby N Weingarten, Mark A Warner
Objective: To determine the risks and outcomes of providing sedation to febrile patients scheduled for bone marrow aspiration or biopsy procedures. Patients and Methods: During the 4-year period from January 1, 2013, through December 31, 2016, data from the periprocedural courses of 12,134 consecutive patients in an outpatient procedure center at a large tertiary medical center were collected retrospectively and analyzed to determine whether febrile patients undergoing bone marrow aspiration and/or biopsy with propofol sedation present a unique patient safety risk...
March 2018: Mayo Clinic proceedings. Innovations, quality & outcomes
Parul Kodan, Nitin Gupta, Ankita Baidya, Ayan Basu, Abdul Razik, Ankit Mittal, Nishant Verma, Bijay Ranjan Mirdha, Sandeep Mathur, Madhu Rajeshwari, Neeraj Nischal, Manish Soneja, Naveet Wig
Filariasis can present in many different ways and pose significant dilemma to the clinician. We report four atypical cases of filariasis which presented as abdominal mass, cervical lymph node enlargement, fever in pregnancy and nosocomial febrile illness respectively. All the four cases were treated successfully with oral antifilarial agents. It is essential to be aware of such atypical presentations of filariasis so that prompt therapy can be initiated.
2018: Drug Discoveries & Therapeutics
Y Yoshida, K Komori, M Aoki, M Sandou, M Takagi, E Uejima
Chemotherapy is among the standard treatments for esophageal cancer. The docetaxel, 5-fluorouracil, and cisplatin (DCF) protocol yields a better response rate than 5-fluorouracil plus cisplatin. However, the incidence of side effects, such as febrile neutropenia and hematologic toxicity, is also significantly high with the DCF protocol. The granulocyte colony-stimulating factor and pegfilgrastim are prophylactically administered to prevent febrile neutropenia. This retrospective study evaluated the efficacy and safety of pegfilgrastim in patients receiving DCF therapy...
October 1, 2018: Die Pharmazie
Hamidah Alias, Woon Lee Yong, Farah Azima Abdul Muttlib, Ho Wai Koo, C-Khai Loh, Sie Chong Doris Lau, Hafiza Alauddin, Raja Zahratul Azma
BACKGROUND: Acquired thrombotic thrombocytopenia purpura is very rarely encountered in children. It is often misdiagnosed initially when the condition is not inherited. CASE PRESENTATION: We describe a 3-year-old Malay boy who presented with simple febrile seizure and had no neurological deficit, however, he was found to have microangiopathic hemolytic anemia, thrombocytopenia, and elevated serum lactate dehydrogenase. An ADAMTS13 assay results showed zero activities (0%), and markedly high level of ADAMTS13 inhibitor (93...
September 17, 2018: Journal of Medical Case Reports
Angela M Phillips, Anna I Ponomarenko, Kenny Chen, Orr Ashenberg, Jiayuan Miao, Sean M McHugh, Vincent L Butty, Charles A Whittaker, Christopher L Moore, Jesse D Bloom, Yu-Shan Lin, Matthew D Shoulders
The threat of viral pandemics demands a comprehensive understanding of evolution at the host-pathogen interface. Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at fever-like temperatures is mediated by host chaperones. Particularly noteworthy, we observe that the Pro283 nucleoprotein variant, which (1) is conserved across human influenza strains, (2) confers resistance to the Myxovirus resistance protein A (MxA) restriction factor, and (3) critically contributed to adaptation to humans in the 1918 pandemic influenza strain, is rendered unfit by heat shock factor 1 inhibition-mediated host chaperone depletion at febrile temperatures...
September 17, 2018: PLoS Biology
Keiko Ishigaki, Chikoto Ihara, Harumasa Nakamura, Madoka Mori-Yoshimura, Kazushi Maruo, Mariko Taniguchi-Ikeda, En Kimura, Terumi Murakami, Takatoshi Sato, Tatsushi Toda, Hisanobu Kaiya, Makiko Osawa
Fukuyama congenital muscular dystrophy (FCMD) is the second most common form of muscular dystrophy in the Japanese population and is caused by mutations in the fukutin (FKTN) gene. In 2011, the Japan Muscular Dystrophy Association (JMDA) developed a nationwide registry of genetically confirmed patients with FCMD. We retrospectively reviewed the registry dataset of patients with FCMD to obtain data, including age, sex, developmental milestones, intellectual level, complications, and primary treatments. In total, 207 patients with FCMD (104 boys and 103 girls) were registered by the end of September 2013...
August 10, 2018: Neuromuscular Disorders: NMD
J Y Zhang, Y X Liu, H Wang, L Mi, G H Song, H F Jiang, Y Yan, B Shao, W Y Kong, R Y Zhang, R Ran, X R Liu, J Wang, Y T Lin, H P Li
Objectives: To investigate the efficacy and safety of prophylactic use of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF) in breast cancer receiving docetaxel as adjuvant chemotherapy. Methods: A total of 58 patients with breast cancer receiving adjuvant chemotherapy with docetaxel were included between January 2014 to October 2017. Prophylactic use of PEG-rhG-CSF was administered.Patients were further divided into two groups according to the frequency of PEG-rhG-CSF use: frequent use group (≥3 cycles) and non-frequent use group (<3 cycles)...
September 11, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Rachna Seth, Jogender Kumar
No abstract text is available yet for this article.
August 15, 2018: Indian Pediatrics
Richa Malik
No abstract text is available yet for this article.
August 15, 2018: Indian Pediatrics
Kristin Bergmann, Hanne Elisabeth Højsgaard Møller, Olav Jonas Bergmann
Febrile neutropenia (FN) is a common complication in patients with cancer during treatment with antineoplastic drugs. The initial cause is usually bacterial, and treatment of FN follows well-defined algorithms. We report a case of a 62-year-old patient with chronic lymphocytic leukaemia (CLL), who developed FN, which was unresponsive to both empirical antibacterial and empirical antifungal therapy. Surprisingly, a diagnosis of the life-threatening condition haemophagocytic lymphohistiocytosis (HLH) associated with cytomegalovirus (CMV) infection was made and treated successfully...
September 14, 2018: BMJ Case Reports
Chandika Gamage, Yomani Sarathkumara, Virajie Weerakkodi, Kanae Shiokawa, Kumiko Yoshimatsu, Jiro Arikawa, Nobuo Koizumi
Monoclonal antibody (MAb)-based ELISA was developed to detect leptospiral antigens from the plasma of febrile patients. The MAb reacts specifically with pathogenic leptospires and the assay possesses excellent diagnostic test parameters compared to PCR, indicating that this new ELISA is useful for the early diagnosis of leptospirosis with low operational cost.
September 11, 2018: Journal of Immunological Methods
Giovanni Grignani, Lorenzo D'Ambrosio, Ymera Pignochino, Emanuela Palmerini, Massimo Zucchetti, Paola Boccone, Sandra Aliberti, Silvia Stacchiotti, Rossella Bertulli, Raimondo Piana, Sara Miano, Francesco Tolomeo, Giulia Chiabotto, Dario Sangiolo, Alberto Pisacane, Angelo Paolo Dei Tos, Luca Novara, Alice Bartolini, Emanuela Marchesi, Maurizio D'Incalci, Alberto Bardelli, Piero Picci, Stefano Ferrari, Massimo Aglietta
BACKGROUND: Trabectedin is an alkylating drug with a unique mechanism of action causing single-strand and double-strand DNA breaks that activate DNA damage-response pathways. Based on our preclinical data, we hypothesised that poly(ADP-ribose) polymerase 1 (PARP1) inhibitors might be an ideal partner of trabectedin and aimed to assess the safety, identify the recommended phase 2 dose, and explore preliminary signs of activity of trabectedin and olaparib combination treatment in patients with bone and soft-tissue sarcoma...
September 11, 2018: Lancet Oncology
Meiling He, Wenting Xu, Lei Zhang, Zengzhi Liu, Jiafeng Zhu, Yuanyuan Li, Shuyan Wu, Hua Niu
Human granulocytic anaplasmosis (HGA), an increasingly recognized febrile tick-borne illness, is caused by a gram-negative obligate intracellular bacterium Anaplasma phagocytophilum. Because of nonspecific clinical manifestations, diagnosis of HGA is highly dependent on laboratory tests. Identification of immunoreactive proteins is prerequisite for specific and sensitive immunoassays for HGA. In this study, we identified novel immunoreactive proteins of A. phagocytophilum. Previous studies indicated that secreted proteins of A...
September 11, 2018: Microbial Pathogenesis
Patrick G Holt, Danny Mok, Debasis Panda, Lynnsey Renn, Giulia Fabozzi, Nick H deKlerk, Merci Mh Kusel, Michael Serralha, Elysia M Hollams, Barbara J Holt, Peter D Sly, Ronald L Rabin
BACKGROUND: Virus-associated febrile lower respiratory tract infections (fLRI) during infancy have been identified as risk factors for persistent wheeze development. We hypothesized that variations in innate immune defence capacity during this period, exemplified by production of types 1 and 3 interferons (T1/3IFNs), may be an underlying determinant of risk. OBJECTIVE: To investigate relationships between postnatal development of innate interferon response capacity and susceptibility to early infections and persistent wheeze...
September 11, 2018: Journal of Allergy and Clinical Immunology
Mark L Higdon, Charles J Atkinson, Kelley V Lawrence
Most oncologic emergencies can be classified as metabolic, hematologic, structural, or treatment related. Tumor lysis syndrome is a metabolic emergency that presents as severe electrolyte abnormalities. Stabilization is focused on vigorous rehydration, maintaining urine output, and lowering uric acid levels. Hypercalcemia of malignancy, which is associated with poor outcomes, is treated with aggressive rehydration, intravenous bisphosphonates, and subspecialty consultation. Syndrome of inappropriate antidiuretic hormone should be suspected if a patient with cancer has hyponatremia...
June 1, 2018: American Family Physician
Yasuhiro Arakawa, Yoshihiro Shirai, Kazumi Hayashi, Yujiro Tanaka, Akira Matsumoto, Katsunori Nishikawa, Shingo Yano
Combination chemotherapy using docetaxel, cisplatin and 5-fluorouracil (DCF) is a promising treatment option for patients with advanced esophageal squamous cell carcinoma (ESCC), although its clinical application is limited by severe systemic toxicities. There are no validated markers for predicting the adverse effects caused by this regimen. This pharmacogenetic study enrolled 57 patients with chemotherapy-naive advanced ESCC between July 2012 and March 2016 (UMIN000008462). All patients received at least one course of DCF chemotherapy (docetaxel, 60 mg/m2 on day 1; cisplatin, 70 mg/m2 on day 1; 5-fluorouracil, 600 mg/m2 on days 1-5)...
October 2018: Oncology Letters
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