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https://www.readbyqxmd.com/read/29775878/repositioning-of-diabetes-treatments-for-depressive-symptoms-a-systematic-review-and-meta-analysis-of-clinical-trials
#1
REVIEW
Calum D Moulton, Christopher W P Hopkins, Khalida Ismail, Daniel Stahl
Depression is a common comorbidity in diabetes but conventional antidepressant treatments do not consistently improve outcomes. We tested whether established diabetes treatments can also improve depressive symptoms and examined biological correlates of response. We performed a multi-database systematic search of all clinical trials, which measured the effect of licensed diabetes treatments on depressive symptoms using a validated questionnaire. Results of randomised controlled trials (RCT's) were pooled for meta-analysis...
May 7, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29772467/yawning-and-cortisol-levels-in-multiple-sclerosis-potential-new-diagnostic-tool
#2
Simon B N Thompson, Alister Coleman, Nicola Williams
Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had been diagnosed with multiple sclerosis. Saliva cortisol samples were collected before and after yawning or after stimuli presentation in the absence of yawning...
May 2, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29762273/patient-engagement-in-aco-practices-and-patient-reported-outcomes-among-adults-with-co-occurring-chronic-disease-and-mental-health-conditions
#3
Susan L Ivey, Stephen M Shortell, Hector P Rodriguez, Yue Emily Wang
BACKGROUND: Accountable care organizations (ACOs) have increased their use of patient activation and engagement strategies, but it is unknown whether they achieve better outcomes for patients with comorbid chronic physical and mental health conditions. OBJECTIVES: To assess the extent to which practices with patient-centered cultures, greater shared decision-making strategies, and better coordination among team members have better patient-reported outcomes (PROs) for patients with diabetes and/or cardiovascular and comorbid mental health diagnoses...
May 12, 2018: Medical Care
https://www.readbyqxmd.com/read/29756417/dehydroepiandrosterone-and-erectile-function-a-review
#4
REVIEW
Ahmed I El-Sakka
To review the contemporary knowledge regarding the dehydroepiandrosterone and erectile function. Medline was reviewed for English-language journal articles spanning the time between January 1990 and December 2017, using the terms 'erectile function', 'dehydroepiandrosterone'. We used Journal Articles and review articles that found to be relevant to the purpose of this review. Criteria included all pertinent review articles, randomized controlled trials with tight methodological design, cohort studies and retrospective analyses...
May 11, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29735476/effect-of-rebound-exercises-and-circuit-training-on-complications-associated-with-type-2-diabetes-protocol-for-a-randomized-controlled-trial
#5
Bashir Kaka, Sonill Sooknunan Maharaj
BACKGROUND: The incidence of type 2 diabetes mellitus, a chronic lifestyle disease, and its complications are on the rise. Exercise has been documented as being effective in the management of musculoskeletal pain, depression, and reduction of hyperglycemia in diabetic patients. However, there is no consensus regarding the types of exercise that reduce musculoskeletal pain and depression and improve quality of life as well as respiratory function among individuals with type 2 diabetes...
May 7, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29728772/implementing-a-mediterranean-style-diet-outside-the-mediterranean-region
#6
REVIEW
Karen J Murphy, Natalie Parletta
PURPOSE OF REVIEW: Populations surrounding the Mediterranean basin have traditionally reaped health benefits from a Mediterranean diet (MedDiet), which may benefit Westernized countries plagued by chronic disease. But is it feasible to implement beyond the Mediterranean? To answer this question, we present evidence from randomized controlled trials that achieved high dietary compliance rates with subsequent physical and mental health benefits. RECENT FINDINGS: In the 1960s, the Seven Countries Study identified dietary qualities of Mediterranean populations associated with healthy aging and longevity...
May 4, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29710725/prevalence-of-dementia-and-associated-risk-factors-a-population-based-study-in-the-philippines
#7
Jacqueline Dominguez, Ma Fe de Guzman, Macario Reandelar, Thien Kieu Thi Phung
BACKGROUND: The Philippines is experiencing rapid demographic aging and with it, the dementia epidemic. Prevalence of dementia and associated risk factors have not been studied in the Philippines. OBJECTIVES: The study aimed to provide a reliable estimate of dementia prevalence and identify associated risk factors in the Filipino population. METHODS: 1460 participants 60 years and older were randomly selected from the Marikina City's senior registry...
April 25, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29703724/outcomes-at-18-months-from-a-community-health-worker-and-peer-leader-diabetes-self-management-program-for-latino-adults
#8
Michael S Spencer, Edith C Kieffer, Brandy Sinco, Gretchen Piatt, Gloria Palmisano, Jaclynn Hawkins, Alana Lebron, Nicolaus Espitia, Tricia Tang, Martha Funnell, Michele Heisler
OBJECTIVE: This study evaluated the effectiveness of a community health worker (CHW) diabetes self-management education (DSME) program, followed by two different approaches to maintain improvements in HbA1c and other clinical and patient-centered outcomes over 18 months. RESEARCH DESIGN AND METHODS: The study randomized 222 Latino adults with type 2 diabetes and poor glycemic control from a federally qualified health center to 1 ) a CHW-led, 6-month DSME program or 2 ) enhanced usual care (EUC)...
April 27, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29686169/risk-factors-for-multidrug-resistant-tuberculosis
#9
Cleopas Martin Rumende
In 2015, 10.4 million people developed tuberculosis (TB) and 580,000 amongst them suffered from multidrug-resistant TB (MDR-TB). From those 580,000 cases of MDR-TB, only 125,000 were detected and reported. A total of 111,000 people began to receive MDR-TB treatment in 2014 while 190,000 MDR-TB patients were estimated to have died, largely due to lack of access to effective treatment. The mechanism of drug resistance can be caused by genetic factors, factors related to previous treatment and other factors such as comorbidity with diabetes mellitus...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29680319/comrade-a-randomized-trial-of-an-individually-tailored-integrated-care-intervention-for-uncontrolled-type-2-diabetes-with-depression-and-or-distress-in-the-rural-southeastern-us
#10
Lesley D Lutes, Doyle M Cummings, Kerry Littlewood, Chelsey Solar, Marissa Carraway, Kari Kirian, Shivajirao Patil, Alyssa Adams, Stefanie Ciszewski, Bertha Hambidge
BACKGROUND: Emerging evidence suggests that people living with Type 2 diabetes mellitus (T2D) are also at greater risk for depression and distress. If left untreated, these comorbid mental health concerns can have long-lasting impacts on medical and physical health outcomes. DESIGN: This prospective trial randomized rural men and women with uncontrolled T2D (HbA1c ≥ 7.0) who screened positive for co-morbid depressive (PHQ-2 > 3) or distress (DDS-2 > 3) symptoms in a primary medical care setting to receive either: 1) 16 sessions of cognitive and/or behavioral intervention tailored to symptom severity across 12 months along with routine medical care, or 2) usual primary care...
April 20, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29671532/vitamin-d-screening-and-supplementation-in-community-dwelling-adults-common-questions-and-answers
#11
Michael L LeFevre, Nicholas M LeFevre
Measurement of vitamin D levels and supplementation with oral vitamin D have become commonplace, although clinical trials have not demonstrated health benefits. The usefulness of serum 25-hydroxyvitamin D levels to assess adequate exposure to vitamin D is hampered by variations in measurement technique and precision. Serum levels less than 12 ng per mL reflect inadequate vitamin D intake for bone health. Levels greater than 20 ng per mL are adequate for 97.5% of the population. Routine vitamin D supplementation does not prolong life, decrease the incidence of cancer or cardiovascular disease, or decrease fracture rates...
February 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29660933/medical-comorbidity-in-alzheimer-s-disease-a-nested-case-control-study
#12
Jen-Hung Wang, Ya-Ju Wu, Boon Lead Tee, Raymond Y Lo
BACKGROUND: Little is known about the distribution of medical comorbidities in Alzheimer's disease (AD). OBJECTIVE: We aimed to describe the comorbidity pattern of AD in a nested case-control study. METHODS: Incident AD cases were identified by International Classification of Diseases codes in a random sample of 2 million individuals in Taiwan National Health Insurance program during 2001-2011. We further restricted cases to those treated with AD drugs of approved reimbursement...
April 11, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29648854/potential-mechanisms-involved-in-the-effect-of-cognitive-behavioral-therapy-on-fatigue-severity-in-type-1-diabetes
#13
Juliane Menting, Cees J Tack, Rogier Donders, Hans Knoop
OBJECTIVE: To identify mediators of the beneficial effect of cognitive-behavioral therapy (CBT) on fatigue severity in chronically fatigued patients with Type 1 diabetes. METHOD: We performed secondary analyses of a randomized controlled trial testing the efficacy of CBT. Primary outcome was fatigue severity assessed with the Checklist Individual Strength, subscale fatigue severity. We used multiple mediation analysis to determine potential mediators of the treatment effect...
April 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29622281/the-effect-of-diabetes-self-management-education-on-psychological-status-and-blood-glucose-in-newly-diagnosed-patients-with-diabetes-type-2
#14
Sanbao Chai, Baoting Yao, Lin Xu, Danyang Wang, Jianbin Sun, Ning Yuan, Xiaomei Zhang, Linong Ji
OBJECTIVE: The purpose of this study was to evaluate the efficacy of self-management education on psychological outcomes and glycemic control in type 2 diabetes mellitus. METHODS: Patients were randomly assigned to education group and control group. Education group received professional education and control group received routine outpatient education. RESULTS: A total of 118 patients were randomly assigned to two groups (education group, n = 63; control group, n = 55)...
March 30, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29615543/intermittent-hypoxia-induces-beneficial-cardiovascular-remodeling-in-left-ventricular-function-of-type-1-diabetic-rat
#15
Fırat Akat, Hakan Fıçıcılar, Ayşegül Durak, Erkan Tuncay, Ali Doğan Dursun, Ferda Topal Çelikkan, Bizden Sabuncuoğlu, Belma Turan, Metin Baştuğ
OBJECTIVE: Depressed mechanical activity is a marked complication in diabetics. Hypoxia has properties for novel diagnostic and therapeutic strategies, while intermittent hypoxia (IH) provides early functional and histologic remodeling, including some cardio benefits in early hemodynamic alterations with histologic remodeling and delayed changes in peripheral vasoreactivity. Therefore, we aimed to examine whether IH application presents a cardioprotective effect, via stabilization of hypoxia-inducible factor (HIF) in streptozotocin (STZ)-induced diabetic rat heart...
April 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29588293/associations-between-changes-in-depressive-symptoms-and-social-support-and-diabetes-management-among-low-income-predominantly-hispanic-patients-in-patient-centered-care
#16
Hyunsung Oh, Kathleen Ell
OBJECTIVE: This study examined whether changes in depressive symptoms and social support prospectively predicted diabetes management among Hispanic patients with probable depression in patient-centered medical homes at safety-net clinics in East Los Angeles, CA. RESEARCH DESIGN AND METHODS: Data were collected from 251 patients enrolled in a randomized clinical trial testing the effectiveness of a promotora-assisted self-management intervention. Cross-lagged analyses examined associations between changes in depression symptoms and social support between baseline and 6-month follow-up and self-efficacy and adherence to diabetes management at the 6- and 12-month follow-ups...
March 27, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29582896/cognitive-dysfunction-in-urban-community-dwelling-prefrail-older-subjects
#17
H Umegaki, T Makino, H Shimada, T Hayashi, X Wu Cheng, M Kuzuya
OBJECTIVES: A number of studies have reported that frailty is cross-sectionally associated with cognitive decline and is also a risk for future cognitive decline or dementia; however, there have been only a few studies that focus on the association between prefrailty and cognitive dysfunction. In the current study, we investigated the association between prefrailty and cognition. DESIGN: A cross-sectional study of the data obtained at registration in a randomized control trial...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29575259/crocin-improves-renal-function-by-declining-nox-4-il-18-and-p53-expression-levels-in-an-experimental-model-of-diabetic-nephropathy
#18
Habib Yaribeygi, Mohammad T Mohammadi, Ramin Rezaee, Amirhossein Sahebkar
Oxidative damage, inflammation and apoptosis play significant roles in diabetic nephropathy. Previous studies demonstrated anti-inflammatory and anti-oxidative effects of crocin, but there is no evidence about its effects on IL-18, NOX-4, and p53 expression in diabetic kidneys. The aim of this study was to evaluate possible effects of crocin on improving main mechanisms underlying diabetic nephropathy. Male Wistar rats were randomly divided into four separate groups as normal (C), normal treated (CC), diabetic (D), and diabetic treated (DC) (n = 6)...
March 25, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29565957/association-of-higher-migraine-risk-among-female-and-younger-chronic-osteomyelitis-patients-evidence-from-a-taiwan-cohort-of-one-million
#19
Jiunn-Horng Chen, Shih-Chi Wu, Chih-Hsin Muo, Chia-Hung Kao, Chun-Hung Tseng, Chon-Haw Tsai
BACKGROUND: Inflammation may trigger migraine development through neurovascular reactions in the brain. Most of the migraine patients, particularly the younger ones, do not have any risk factors for this disease. Hence, we assessed whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases the risk of migraine. OBJECTIVE: We aim to evaluate the risk of migraine among female and middle-age COM patients with a large patient sample. STUDY DESIGN: A retrospective cohort study was conducted in this study...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29548302/comparing-dedicated-and-designated-models-of-integrating-mental-health-into-chronic-disease-care-study-protocol-for-a-cluster-randomized-controlled-trial
#20
Bronwyn Myers, Crick Lund, Carl Lombard, John Joska, Naomi Levitt, Christopher Butler, Susan Cleary, Tracey Naledi, Peter Milligan, Dan J Stein, Katherine Sorsdahl
BACKGROUND: In low- and middle-income countries (LMIC), it is uncertain whether a "dedicated" approach to integrating mental health care (wherein a community health worker (CHW) has the sole responsibility of delivering mental health care) or a "designated" approach (wherein a CHW provides this service in addition to usual responsibilities) is most effective and cost-effective. This study aims to compare the effectiveness and cost-effectiveness of these two models of service integration relative to treatment as usual (TAU) for improving mental health and chronic disease outcomes among patients with HIV or diabetes...
March 16, 2018: Trials
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