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https://www.readbyqxmd.com/read/27933671/causal-inference-in-obesity-research
#1
REVIEW
P W Franks, N Atabaki-Pasdar
Obesity is a risk factor for a plethora of severe morbidities and premature death. Most supporting evidence comes from observational studies that are prone to chance, bias and confounding. Even data on the protective effects of weight loss from randomized controlled trials will be susceptible to confounding and bias if treatment assignment cannot be masked, which is usually the case with lifestyle and surgical interventions. Thus, whilst obesity is widely considered the major modifiable risk factor for many chronic diseases, its causes and consequences are often difficult to determine...
December 8, 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27928888/self-care-tools-to-treat-depressive-symptoms-in-patients-with-age-related-eye-disease-a-randomized-controlled-clinical-trial
#2
Hortence Kamga, Jane McCusker, Mark Yaffe, Maida Sewitch, Tamara Sussman, Erin Strumpf, Sébastien Olivier, Walter Wittich, Solmaz Moghadaszadeh, Ellen E Freeman
BACKGROUND: Depression is very common in people with age-related eye disease. Our goal was to determine if self-care tools plus limited telephone support could reduce depressive symptoms in patients with age-related macular degeneration (AMD) or diabetic retinopathy (DR). DESIGN: A single-blind randomized controlled clinical trial was conducted at Maisonneuve-Rosemont Hospital in Montreal, Canada. PARTICIPANTS: Eighty participants were recruited METHODS: To be eligible, participants must have had either late stage AMD or DR, at least mild depressive symptoms, and visual acuity better than 20/200...
December 7, 2016: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/27911049/family-partners-in-lifestyle-support-pals-family-based-weight-loss-for-african-american-adults-with-type-2-diabetes
#3
Carmen D Samuel-Hodge, Judith C Holder-Cooper, Ziya Gizlice, Gwendolyn Davis, Sonia P Steele, Thomas C Keyserling, Shiriki K Kumanyika, Phillip J Brantley, Laura P Svetkey
OBJECTIVE: To develop and test a family-centered behavioral weight loss intervention for African American adults with type 2 diabetes. METHODS: In this randomized trial, dyads consisting of an African American adult with overweight or obesity and type 2 diabetes (index participant) paired with a family partner with overweight or obesity but not diagnosed with diabetes were assigned in a 2:1 ratio to a 20-week special intervention (SI) or delayed intervention (DI) control group...
December 2, 2016: Obesity
https://www.readbyqxmd.com/read/27897469/a-randomized-controlled-trial-investigating-a-paraprofessional-led-self-management-coaching-program-for-community-dwelling-patients-with-type-2-diabetes-prescribed-insulin
#4
Tim Pauley, Judith Gargaro, Glen Chenard, Helen Cavanagh, Sandra M McKay
This study evaluated paraprofessional-led diabetes self-management coaching (DSMC). Subjects were randomized to standard care or standard care plus coaching. Measures included the Diabetes Self-Efficacy Scale (DSES), Insulin Management Self-Efficacy Scale (IMDSES), and Hospital Anxiety and Depression Scale (HADS). Both groups improvement in DSES (6.6 + 1.5 vs. 7.2 + 1.5, p < .001) and IMDSES (113.5 + 20.6 vs. 125.7 + 22.3, p < .001); there were no between-groups differences. There were no between-groups differences in anxiety (p > ...
November 29, 2016: Home Health Care Services Quarterly
https://www.readbyqxmd.com/read/27894461/does-mindfulness-based-cognitive-therapy-benefit-all-people-with-diabetes-and-comorbid-emotional-complaints-equally-moderators-in-the-diamind-trial
#5
Ivan Nyklíček, Jenny van Son, Victor J Pop, Johan Denollet, François Pouwer
OBJECTIVES: Research has shown the effectiveness of mindfulness-based interventions for a variety of emotional problems in different samples, but it is unknown which factors influence this effectiveness. Therefore, the aim of the current study was: which factors (demographic, personality, and baseline levels of mindfulness skills) moderate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT)? METHODS: Outpatients with diabetes (type 1 or type 2; N=139) and an elevated level of emotional distress participated in the Diabetes and Mindfulness (DiaMind) trial...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27888118/increased-risk-of-new-onset-fibromyalgia-among-chronic-osteomyelitis-patients-evidence-from-a-taiwan-cohort-study
#6
Jiunn-Horng Chen, Chih-Hsin Muo, Chia-Hung Kao, Chon-Haw Tsai, Chun-Hung Tseng
: Chronic inflammation, which changes the neurotransmitter metabolism and kindles neuroendocrine system dysfunction in central nervous system, might cause fibromyalgia (FM) formation. In FM patients without traditional FM risk factors, such as hypertension, hyperlipidemia, diabetes, sleep disorder, depression, and anxiety, chronic inflammatory process is a possible risk factor for FM. Thus, we investigated whether chronic osteomyelitis (COM), a disease characterized by chronic inflammation, increases FM risk...
November 22, 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27882442/the-effects-of-zofenopril-on-cardiac-function-and-pro-oxidative-parameters-in-the-streptozotocin-induced-diabetic-rat-heart
#7
Petar Ristic, Ivan Srejovic, Tamara Nikolic, Isidora Stojic, Dragana Ristic, Vladimir Zivkovic, Vladimir Lj Jakovljevic
Diabetes mellitus is a chronic condition that continues to increase in both incidence and prevalence. Renin-Angiotensin-Aldosterone System is one of the main modulators of chronic hyperglycaemia and, thus, its influence on tissues. Hyperglycaemia-induced oxidative stress is an important factor in diabetic cardiomyopathy. The present study was carried out on 24 adult male Wistar albino rats (8-week-old and with body masses of 190 ± 10 g). We evaluated the influence of acute administration of zofenopril on ex vivo myocardial function from rats with streptozotocin-induced diabetes mellitus, with a special emphasis on cardiodynamic and oxidative stress parameters in diabetic rat hearts...
November 24, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27855438/how-to-prevent-depression-current-directions-and-future-challenges-in-children-with-chronic-medical-conditions
#8
Anna Felnhofer, Oswald D Kothgassner, Claudia Klier
With its high rates of chronicity and concomitant economic costs to society, depression ranges among the most prevalent mental disorders. Several trials have succeeded in demonstrating the beneficial effects of early depression prevention programs for otherwise healthy children and adolescents. However, comparable programs for children and adolescents with a medical condition are still scarce. This paper discusses the situation of chronically ill children and adolescents who are at risk of developing comorbid depressive symptoms using the example of three conditions frequently encountered in pediatric psychosomatic medicine: diabetes, epilepsy and inflammatory bowel disease (IBD)...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27845333/habitual-coffee-consumption-and-risk-of-type-2-diabetes-ischemic-heart-disease-depression-and-alzheimer-s-disease-a-mendelian-randomization-study
#9
Man Ki Kwok, Gabriel M Leung, C Mary Schooling
Observationally, coffee is inversely associated with type 2 diabetes mellitus (T2DM), depression and Alzheimer's disease, but not ischemic heart disease (IHD). Coffee features as possibly protective in the 2015 Dietary Guidelines for Americans. Short-term trials suggest coffee has neutral effect on most glycemic traits, but raises lipids and adiponectin. To clarify we compared T2DM, depression, Alzheimer's disease, and IHD and its risk factors by genetically predicted coffee consumption using two-sample Mendelian randomization applied to large extensively genotyped case-control and cross-sectional studies...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27831985/randomized-double-blind-placebo-controlled-phase-iii-trial-of-duloxetine-monotherapy-in-japanese-patients-with-chronic-low-back-pain
#10
Shinichi Konno, Natsuko Oda, Toshimitsu Ochiai, Levent Alev
STUDY DESIGN: A 14-week, randomized, double-blind, multicenter, placebo-controlled study of Japanese patients with chronic low back pain (CLBP) who were randomized to either duloxetine 60 mg once daily or placebo. OBJECTIVE: This study aimed to assess the efficacy and safety of duloxetine monotherapy in Japanese patients with CLBP. SUMMARY OF BACKGROUND DATA: In Japan, duloxetine is approved for the treatment of depression, diabetic neuropathic pain, and pain associated with fibromyalgia; however, no clinical study of duloxetine has been conducted for CLBP...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27807794/low-testosterone-in-men-with-cardiovascular-disease-or-risk-factors-to-treat-or-not-to-treat
#11
REVIEW
Dimitri C Cassimatis, Matthew T Crim, Nanette K Wenger
Current evidence supports the use of testosterone replacement in men with the clinical-biochemical syndrome of hypogonadism, defined as low testosterone serum levels and symptoms such as fatigue, exercise intolerance, erectile dysfunction, low libido, or depression. Although the evidence consistently shows that hypogonadism is associated with elevated cardiovascular risk, evidence is mixed regarding whether testosterone (T) replacement provides cardiovascular (CV) benefit or harm. For a man with symptomatic hypogonadism in the setting of CV disease, clinical heart failure, and/or traditional CV risk factors (hypertension, diabetes, and hyperlipidemia), a balanced approach would be to counsel him that overall, the evidence should not dissuade him from utilizing T replacement for non-cardiac symptom relief but that more data are needed before a definitive recommendation can be made about T replacement for CV benefit...
December 2016: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27784343/patterns-of-association-of-chronic-medical-conditions-and-major-depression
#12
S B Patten, J V A Williams, D H Lavorato, J L Wang, N Jetté, T T Sajobi, K M Fiest, A G M Bulloch
AIMS: Age and sex-related patterns of association between medical conditions and major depressive episodes (MDE) are important for understanding disease burden, anticipating clinical needs and for formulating etiological hypotheses. General population estimates are especially valuable because they are not distorted by help-seeking behaviours. However, even large population surveys often deliver inadequate precision to adequately describe such patterns. In this study, data from a set of national surveys were pooled to increase precision, supporting more precise characterisation of these associations...
October 27, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27781388/the-dialysis-outcomes-and-practice-patterns-study-dopps-in-turkey
#13
Tevfik Ecder, Cengiz Utas, Kenan Ates, Brian Bieber, Bruce M Robinson, Ronald L Pisoni, Gültekin Süleymanlar
Introduction Turkey has one of the largest treated end-stage renal disease (ESRD) patient populations in Europe (N = 66,711). In 2013, the international Dialysis Outcomes and Practice Patterns Study (DOPPS), a prospective study of hemodialysis (HD) practices and outcomes, initiated data collection in Turkey. Here we provide comparisons of HD patients in DOPPS-Turkey with other international regions and with patients in the Registry of Turkish Nephrology, Dialysis and Transplantation. Methods DOPPS-Turkey study sites were randomly selected from all Turkish HD units treating ≥25 in-center chronic HD patients...
October 25, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27769955/do-web-based-interventions-improve-well-being-in-type-2-diabetes-a-systematic-review-and-meta-analysis
#14
Michelle Hadjiconstantinou, Jo Byrne, Danielle H Bodicoat, Noelle Robertson, Helen Eborall, Kamlesh Khunti, Melanie J Davies
BACKGROUND: Poor diabetes self-care can have a negative impact on psychological well-being and quality of life. Given the scarcity of traditional psychological support and the barriers to uptake of and attendance at face-to-face education programs, Web-based interventions are becoming a popular approach to provide an additional platform for psychological support in long-term conditions. However, there is limited evidence to assess the effect of Web-based psychological support in people with type 2 diabetes...
October 21, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27763623/change-in-health-status-in-copd-a-seven-year-follow-up-cohort-study
#15
Josefin Sundh, Scott Montgomery, Mikael Hasselgren, Mary Kämpe, Christer Janson, Björn Ställberg, Karin Lisspers
Health status is a prognostic factor included in the assessment of chronic obstructive pulmonary disease (COPD). The aim of our study was to examine the associations of clinical factors with change in health status over a 7-year follow-up period. In 2005, 970 randomly selected primary and secondary care patients with a COPD diagnosis completed questionnaires including the Clinical COPD Questionnaire (CCQ); and in 2012, 413 completed the CCQ questionnaire again. Linear regression used difference in mean total CCQ score between 2005 and 2012 as the dependent variable...
October 20, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27754282/hw-04-3-global-network-for-her-based-big-data-analysis
#16
Peter Rijnbeek
Massive numbers of electronic health records are currently being collected globally, including structured data in the form of diagnoses, medications, laboratory test results, and unstructured data contained in clinical narratives. This opens unprecedented possibilities for research and ultimately patient care. However, actual use of these databases in a multi-center study is severely hampered by a variety of challenges, e.g., each database has a different database structure and uses different terminology systems...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27733954/feasibility-and-acceptability-of-a-positive-psychological-intervention-for-patients-with-type-2-diabetes
#17
Christina M DuBois, Rachel A Millstein, Christopher M Celano, Deborah J Wexler, Jeff C Huffman
OBJECTIVE: Positive psychological attributes (eg, optimism) have been associated with a healthier lifestyle and superior medical outcomes in patients with type 2 diabetes; however, there has been minimal study of behavioral interventions that target positive psychological constructs in this population. Accordingly, we developed a novel, telephone-based, 12-week positive psychology intervention and assessed its feasibility and short-term impact in adults with type 2 diabetes and suboptimal health behavior adherence...
2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27688858/is-it-possible-to-delay-or-prevent-age-related-cognitive-decline
#18
REVIEW
Jean-Pierre Michel
Already in the 90s, Khachaturian stated that postponing dementia onset by five years would decrease the prevalence of the late onset dementia by 50%. After two decades of lack of success in dementia drug discovery and development, and knowing that worldwide, currently 36 million patients have been diagnosed with Alzheimer's disease, a number that will double by 2030 and triple by 2050, the World Health Organization and the Alzheimer's Disease International declared that prevention of cognitive decline was a 'public health priority...
September 2016: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/27662442/perceptions-of-provider-communication-among-vulnerable-patients-with-diabetes-influences-of-medical-mistrust-and-health-literacy
#19
Richard O White, Rosette J Chakkalakal, Caroline A Presley, Aihua Bian, Jonathan S Schildcrout, Kenneth A Wallston, Shari Barto, Sunil Kripalani, Russell Rothman
Patient-provider communication is modifiable and is linked to diabetes outcomes. The association of communication quality with medical mistrust is unknown. We examined these factors within the context of a low-literacy/numeracy-focused intervention to improve diabetes care, using baseline data from diverse patients enrolled in a randomized trial of a health communication intervention. Demographics, measures of health communication (Communication Assessment Tool [CAT], Interpersonal Processes of Care survey [IPC-18]), health literacy (Short Test of Functional Health Literacy in Adults), depression, medical mistrust, and glycemic control were ascertained...
2016: Journal of Health Communication
https://www.readbyqxmd.com/read/27643279/hw-04-3-global-network-for-her-based-big-data-analysis
#20
Peter Rijnbeek
Massive numbers of electronic health records are currently being collected globally, including structured data in the form of diagnoses, medications, laboratory test results, and unstructured data contained in clinical narratives. This opens unprecedented possibilities for research and ultimately patient care. However, actual use of these databases in a multi-center study is severely hampered by a variety of challenges, e.g., each database has a different database structure and uses different terminology systems...
September 2016: Journal of Hypertension
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