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Nicholas Wettersten, Hao Tran, Kristin Mekeel, Gert Pretorius, Eric Adler, Saima Aslam
Every year the number of patients waiting for a heart transplant increases faster than the number of available donor organs. Some potential donor organs are from donors with active communicable diseases, including hepatitis C virus (HCV), potentially making donation prohibitive. The advent of direct-acting antiviral agents for HCV has drastically changed the treatment of HCV. Recently, these agents have been used to treat HCV in organ donor recipients who acquired the disease from the donor organ. We report a case of heart-kidney transplantation from an HCV viremic donor to HCV negative recipient with successful treatment and sustained virologic response...
September 17, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
David W Donnelly, Therese Kearney, Eilis McCaughan, Amy Downing, David Weller, Adam W Glaser, Anna Gavin
BACKGROUND: Erectile dysfunction is common among older men; however, diagnosis and treatment compared to reported prevalence is low. We aim to identify the degree to which older men are offered treatment for the condition and determine the level of unmet need within Northern Ireland (NI). METHODOLOGY: Analysis of data collected using a cross-sectional survey was conducted for men aged ≥60 years with data weighted to the NI population by age and deprivation. Respondents answered questions on sociodemographic factors, health-related characteristics, ability to function sexually, level of sexual interest and activity, and any treatment offered to improve erections in the last 3 years...
September 17, 2018: International Journal of Clinical Practice
Romy M Heilmann, Jörg M Steiner
Chronic inflammatory enteropathies (CIE) in dogs are a group of disorders that are characterized by chronic persistent or recurrent signs of gastrointestinal disease and histologic evidence of mucosal inflammation. These CIEs are classified as either food-responsive, antibiotic-responsive, or immunosuppressant-responsive enteropathy. Patients not clinically responding to immunomodulatory treatment are grouped as nonresponsive enteropathy and dogs with intestinal protein loss as protein-losing enteropathy. Disease-independent clinical scoring systems were established in dogs for assessment of clinical disease severity and patient monitoring during treatment...
September 17, 2018: Journal of Veterinary Internal Medicine
Dimitra Magkou, Christine DoCao, Claire Bouvattier, Claire Douillard, Capucine de Marcellus, Laure Cazabat, Maxime Gérard, Marie-Laure Raffin-Sanson, Jacques Young
OBJECTIVE: Mitotane/o,p'DDD is used in the treatment of adrenocortical carcinoma and for other causes of hypercortisolism. Mitotane inhibits cortisol secretion and displays adrenolytic and antitumor actions. This compound is a metabolite of the pesticide and endocrine disruptor DDT (Dichlorodiphenyltrichloroethane) and is classified among teratogenic compounds worldwide. However, little is known about its effects on human development. DESIGN: The outcome of four children exposed to mitotane during their intrauterine life was examined...
September 17, 2018: Clinical Endocrinology
Kathrin Herrmann, Paul Flecknell
Pain has a profound effect on an animal's wellbeing. In Germany, researchers using animals have been legally required since 1972 to reduce any possible pain, suffering, distress or lasting harm to an absolute minimum. To evaluate how these provisions have been implemented in practice, an assessment of refinements to experimental techniques was conducted by retrospectively reviewing 684 surgical interventions described in 506 animal research applications that were sent to the German competent authorities for approval in 2010...
September 14, 2018: ALTEX
Paula de Marchi Scarpin Hagemann, Luis Cuadrado Martin, Carmen Maria Bueno Neme
INTRODUCTION: The sources of stress involved in chronic kidney disease (CKD) can lead to depressive states, directly affecting the hemodialysis patient's quality of life (QOL). There are few reports and studies on therapeutic interventions that aim to minimize depressive symptoms in these patients and an even greater shortage of studies using music therapy. OBJECTIVE: This study evaluated the effect of music therapy on QOL and depressive symptoms in hemodialysis patients...
September 13, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Amanda L Forster, Viviana Rodriguez Cardenas, Ajay Krishnamurthy, Zois Tsinas, Amy Engelbrecht-Wiggans, Nolan Gonzalez
Traditionally, soft body armor has been made from poly(p-phenylene terephthalamide) (PPTA) and ultra-high molecular weight polyethylene. However, to diversify the fiber choices in the United States body armor market, copolymer fibers based on the combination of 5-amino-2-(p-aminophenyl) benzimidazole (PBIA) and the more conventional PPTA were introduced. Little is known regarding the long-term stability of these fibers, but as condensation polymers, they are expected to have potential sensitivity to moisture and humidity...
September 1, 2018: Journal of Visualized Experiments: JoVE
Jacob M Dixon, Shunji Egusa
The purpose of the presented protocols is to study the process of Au(III) binding to BSA, yielding conformation change-induced red fluorescence (λem = 640 nm) of BSA-Au(III) complexes. The method adjusts the pH to show that the emergence of the red fluorescence is correlated with the pH-induced equilibrium transitions of the BSA conformations. Red fluorescent BSA-Au(III) complexes can only be formed with an adjustment of pH at or above 9.7, which corresponds to the "A-form" conformation of BSA. The protocol to adjust the BSA to Au molar ratio and to monitor the time-course of the process of Au(III) binding is described...
August 31, 2018: Journal of Visualized Experiments: JoVE
Eirill Ager-Wick, Kjetil Hodne, Romain Fontaine, Kristine von Krogh, Trude M Haug, Finn-Arne Weltzien
Primary cell culture is a powerful tool commonly used by scientists to study cellular properties and mechanisms of isolated cells in a controlled environment. Despite vast differences in the physiology between mammals and fish, primary cell culture protocols from fish are often based on mammalian culture conditions, often with only minor modifications. The environmental differences affect not only body temperature, but also blood serum parameters such as osmolality, pH, and pH buffer capacity. As cell culture media and similar working solutions are meant to mimic characteristics of the extracellular fluid and/or blood serum to which a cell is adapted, it is crucial that these parameters are adjusted specifically to the animal in question...
August 28, 2018: Journal of Visualized Experiments: JoVE
Rosa di Mundo, Francesco Bottiglione, Giuseppe Pascazio, Giuseppe Carbone
Hydrophobic and superhydrophobic solid Teflon spheres have been observed while settling in water under the action of gravity, starting from different initial conditions and followed until the steady-state is reached. The superhydrophobic sphere features a nano/microtextured surface and advancing and receding water contact angles of, respectively, 162° and 160°. When impacting water from air, both spheres can entrap a conspicuous amount of air deriving from the sealing of a macro-sized air cavity formed upon impact (air cavity trapping) and standing at the rear part of the settling sphere...
September 17, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Ann Lii-Rosales, Yong Han, Ka Man Yu, Dapeng Jing, Nathaniel Andrew Anderson, David Vaknin, Michael C Tringides, J W Evans, Michael S Altman, Patricia A Thiel
Using scanning tunneling microscopy, X-ray photoelectron spectroscopy, and X-ray absorption spectroscopy, we show that Ru forms metallic nanoislands on graphite, covered by a graphene monolayer. These islands are air-stable, contain 2-4 layers of Ru, and have diameters on the order of 10 nm. To produce these nanoislands two conditions must be met during synthesis. The graphite surface must be ion-bombarded, and subsequently held at elevated temperature (1000-1180 K) during Ru deposition. A coincidence lattice forms between the graphene overlayer and the Ru island top...
September 17, 2018: Nanotechnology
Jun-Won Lee, Sang Wook Park, Jung-Woo Son, Sung-Gyun Ahn, Seung-Hwan Lee
AIMS: This study aimed to evaluate the feasibility and safety of the left distal transradial approach (ldTRA) as a default route for coronary angiography (CAG) and percutaneous coronary intervention (PCI). METHODS AND RESULTS: Between 11 Oct 2017 and 9 Jan 2018, 200 consecutive patients were enrolled in a single centre. The radial artery was punctured with a 20-gauge venipuncture catheter needle by three expert left radial approach operators. The success rates of arterial puncture, CAG, and PCI were 95...
September 18, 2018: EuroIntervention
Nicolas Amabile, Geraud Souteyrand, Pascal Motreff, Christophe Caussin
No abstract text is available yet for this article.
September 18, 2018: EuroIntervention
Alexandre Abizaid, Sasko Kedev, Elvin Kedhi, Suneel Talwar, Andrejs Erglis, Ota Hlinomaz, Monica Masotti, Farzin Fath-Ordoubadi, Pedro A Lemos, Krzysztof Milewski, Roberto Botelho, Ricardo Costa, Sripal Bangalore
AIMS: To evaluate the safety and efficacy of BioMime™ sirolimus-eluting coronary stent (SES) compared to the XIENCE family everolimus-eluting coronary stent (EES) in the treatment of patients with de novo native coronary artery lesions. METHODS AND RESULTS: The meriT-V is a prospective, multicenter, randomized, open-label, active-controlled, and non-inferiority trial. A total of 256 patients with up to two de novo native coronary artery lesions were enrolled and randomly assigned (2:1) to BioMime SES or XIENCE EES...
September 18, 2018: EuroIntervention
Fernando Macaya, Pablo Salinas, Nieves Gonzalo, Santiago J Camacho-Freire, Robert Jackson, Montse Massot, María R Ortas-Nadal, Ángel Sánchez-Recalde, José F Díaz-Fernández, José Moreu, David Adlam, Javier Escaned
No abstract text is available yet for this article.
September 18, 2018: EuroIntervention
Laurens J C Van Zandvoort, Dariusz Dudek, Joachim Weber-Albers, Alexandre Abizaid, Evald Høj Christiansen, David W M Muller, Janusz Kochman, Łukasz Kołtowski, Jens Lassen, Roman Wojdyla, Joanna J Wykrzykowska, Yoshinobu Onuma, Joost Daemen
AIMS: FANTOM II is a prospective multicenter trial assessing the safety and efficacy of the Fantom Sirolimus-Eluting Bioresorbable Coronary Scaffold (BRS). The present substudy focuses on the 6 and 9 months IVUS findings. METHODS AND RESULTS: A total of 240 patients with de novo coronary artery lesions presenting with stable or unstable disease were included in 2 sequential cohorts (cohort A (n=117) and B (n=123) in which angiographic follow-up was performed at either 6 or 9 months respectively...
September 18, 2018: EuroIntervention
J Barbarroja-Escudero, A Asúnsolo-Del-Barco, M J Sánchez-González, M Rodríguez-Rodríguez, M Alvarez-Mon
BACKGROUND AND OBJECTIVE: Edema of the uvula (EU) may appear in isolation or in association with other associated clinical manifestations such as urticaria, angioedema or anaphylaxis. EU may lead to upper airway obstruction, provoking obstructive respiratory distress and asphyxia. Objective: We sought to investigate the etiology of, and predisposing factors for, EU in a large population of patients referred to an outpatient clinic. METHODS: In this 3-year-follow-up cohort study, 171 patients presenting with EU were identified and classified as having isolated EU or non-isolated EU...
September 17, 2018: Journal of Investigational Allergology & Clinical Immunology
Justyna Ulanska-Poutanen, Jakub Mieczkowski, Chao Zhao, Katarzyna Konarzewska, Beata Kaza, Hartmut Bf Pohl, Lukasz Bugajski, Bozena Kaminska, Robin Jm Franklin, Malgorzata Zawadzka
Following CNS demyelination, oligodendrocyte progenitor cells (OPCs) are able to differentiate into either remyelinating oligodendrocytes (OLs) or remyelinating Schwann cells (SCs). However, the signals that determine which type of remyelinating cell is generated and the underlying mechanisms involved have not been identified. Here, we show that distinctive microenvironments created in discrete niches within demyelinated white matter determine fate decisions of adult OPCs. By comparative transcriptome profiling we demonstrate that an ectopic, injury-induced perivascular niche is enriched with secreted ligands of the BMP and Wnt signalling pathways, produced by activated OPCs and endothelium, whereas reactive astrocyte within non-vascular area express the dual BMP/Wnt antagonist Sostdc1...
September 17, 2018: ELife
Naoki Nakano, Laughter Lisenda, Vikas Khanduja
Subspine impingement is an extra-articular hip impingement syndrome that usually occurs when there is abnormal contact between an enlarged or malorientated anterior inferior iliac spine (AIIS) and the distal anterior femoral neck in straight flexion of the hip. We present the case of a 13-year-old boy with a history of left groin pain and loss of range of movement of the hip for over six months following an avulsion fracture of the AIIS during a game of rugby. He was diagnosed with subspine impingement secondary to a large lesion of heterotopic ossification in the rectus femoris; this was dissected and extracted from the muscle in toto arthroscopically...
2018: SICOT-J
Patricia Bedrunka, Fabien Olbrisch, Martina Rüger, Susanne Zehner, Nicole Frankenberg-Dinkel
The ubiquitous bacterial second messenger bis-(3'-5')-cyclic dimeric GMP (c-di-GMP) is involved in the regulation of numerous processes including biofilm formation, motility, virulence, cell cycle and differentiation. In this study, we searched the genome of the ecologically important marine alphaproteobacterium Dinoroseobacter shibae DFL12T for genes encoding putative c-di-GMP-modulating enzymes. Overall, D. shibae was found to possess two diguanylate cyclases (Dshi_2814 and Dshi_2820) as well as two c-di-GMP-specific phosphodiesterases (Dhi_0329 and Dshi_3065)...
September 17, 2018: Microbiology
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