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Georgia Mitropoulou, Laurent P Nicod, Maura Prella
Chronic hypercapnic respiratory failure is essentially a ventilatory failure. Noninvasive ventilation (NIV ) reduces the work of breathing, improves pulmonary compliance and alveolar ventilation, corrects gas exchange disorders and improves dyspnoea. However, treatment efficacy depends on the underlying pathology, on correct timing and on patient compliance. In this context, the principal role of the primary care physician is to search for, at every visit of at risk patients, signs and symptoms of ventilatory failure and to refer the patient to a respiratory care specialist...
November 14, 2018: Revue Médicale Suisse
Yan Li, Huafang Li, Yucheng Sheng, Xin Du, Yuhui Yao, Xian Luo, Peiming Ma
The pharmacokinetics (PK) and safety of single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) after single and repeat dosing in healthy Chinese adults were assessed. In this open-label study (NCT02837380), subjects received once-daily FF/UMEC/VI 100/62.5/25 μg on day 1 and repeat doses on days 2-7. PK parameters (days 1 and 7) included maximum observed concentration (Cmax ) and area under the plasma concentration-time curve (AUC) from time zero (predose) to last time of quantifiable concentration (AUC0-t )...
November 14, 2018: Clinical Pharmacology in Drug Development
Jim J Xiao, Dorota Nowak, Rodryg Ramlau, Monika Tomaszewska-Kiecana, Piotr J Wysocki, Jeff Isaacson, Jeri Beltman, Eileen Nash, Robert Kaczanowski, Gerhard Arold, Simon Watkins
This phase 1 study (CO-338-044; NCT02740712), conducted in patients with an advanced solid tumor, evaluated the effect of the poly(ADP-ribose) polymerase inhibitor rucaparib on the pharmacokinetics of caffeine 200 mg, warfarin 10 mg, omeprazole 40 mg, and midazolam 2 mg (cytochrome P450 [CYP] 1A2, CYP2C9, CYP2C19, and CYP3A substrates; dosed as a cocktail) and digoxin 0.25 mg (P-glycoprotein substrate; dosed separately) without rucaparib and following oral rucaparib 600 mg twice daily (BID). Geometric mean (GM) ratios (90% CI) of AUC from time zero to last quantifiable measurement with and without rucaparib were: caffeine, 2...
November 14, 2018: Clinical and Translational Science
S Fakhri, L Dargahi, F Abbaszadeh, M Jorjani
BACKGROUND: Spinal cord injury (SCI) causes continuous neurological deficits and major sensory-motor impairments. There is no effective treatment to enhance sensory-motor function following SCI. Thus, it is crucial to develop novel therapeutics for this particular patient population. Astaxanthin (AST) is a strong anti-oxidant, anti-inflammatory, and anti-apoptotic agent. In the present study, it was tested in a severe compression SCI model with emphasis on sensory-motor outcomes, signaling pathway, along with other complications...
November 14, 2018: European Journal of Pain: EJP
Mohamed Samih Alsrouji, Rohana Ahmad, Aiemeeza Rajali, Nor Wati Nur Atikah Mustafa, Norliza Ibrahim, Nadim Z Baba Dmd
PURPOSE: To compare the residual ridge resorption (RRR) of the anterior maxillary bone beneath complete denture when opposed by a mandibular complete denture (CD) and implant-retained overdenture (IRO). MATERIALS AND METHODS: 18 patients were rehabilitated with maxillary CD opposing mandibular IRO, and 4 patients were prescribed with conventional CD. Cone beam computed tomography (CBCT) scans of the maxilla were acquired before and 1 year post-treatment and converted into 3D models using Mimics research software...
November 14, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
Pieter Evenepoel, Kathleen Claes, Bjorn Meijers, Michaël Laurent, Bert Bammens, Maarten Naesens, Ben Sprangers, Hans Pottel, Etienne Cavalier, Dirk Kuypers
Chronic kidney disease and osteoporosis are major public health problems associated with an aging population. Vitamin K insufficiency is prevalent among patients with end-stage renal disease (ESRD). Preliminary data indicate that poor vitamin K status may compromise bone health and that increased inflammation may be in the causal pathway. We performed an ancillary analysis of data collected in the frame of prospective observational cohort studies exploring various aspects of bone health in de novo renal transplant recipients to investigate the association between vitamin K status, inflammation, bone mineral density, and incident clinical fractures...
November 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Adriana C Vidal, Lauren E Howard, Amanda De Hoedt, Christopher J Kane, Martha K Terris, William J Aronson, Matthew R Cooperberg, Christopher L Amling, Stanislav Lechpammer, Scott C Flanders, Stephen J Freedland
BACKGROUND: In this study among men who underwent radical prostatectomy (RP), African American men (AAM) were 28% more likely to develop recurrent disease compared with Caucasian men (CM). However, among those who had nonmetastatic, castration-resistant prostate cancer (CRPC), race did not predict metastases or overall survival. Whether race predicts metastases among men who receive androgen-deprivation therapy (ADT) after a biochemical recurrence (BCR) (ie, before CRPC but after BCR) is untested...
November 14, 2018: Cancer
Maria Juliete Souza Rocha, Gabriela Tomas Jerônimo, Oscar Tadeu Ferreira da Costa, José Celso de Oliveira Malta, Maurício Laterça Martins, Patricia Oliveira Maciel, Edsandra Campos Chagas
The aim of this study was to evaluate the impacts of metazoan parasites on hematological and biochemical parameters and relative condition factor of tambaqui (Colossoma macropomum ) farmed in northern Brazil. A total of 32 juvenile fish were captured from a commercial fish farm located in the municipality of Rio Preto da Eva, Amazonas state, Brazil. Parasite prevalence was 100% for Anacanthorus spathulatus, Mymarothecium boegeri and Notozothecium janauachensis, 100% for Neoechinorhynchus buttnerae and 53.13% for Dolops geayi...
November 8, 2018: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
Maria Izabel Romão Lopes, Juliana Benevenuto Tornai, Fernanda Letkaske de Miranda Jeng, Bianca di Virgilio Lopes, Gabriel André da Silva Mendes, Matheus Fernandes de Oliveira, Fernando Campos Gomes Pinto
OBJECTIVE: The current study translated to Portuguese and validated the normal pressure hydrocephalus (NPH) scale originally developed in English as the Grading Scale for Idiopathic Normal Pressure Hydrocephalus. METHODS: Following Guillemin's validation protocol, the last version of the Portuguese NPH scale was applied to 121 consecutive patients with a diagnosis of normal pressure hydrocephalus (73 men and 48 women) from the Group of Cerebral Hydrodynamics from July 2010 to March 2012...
October 2018: Arquivos de Neuro-psiquiatria
Marcos C Lange, Gustavo Ribas, Valeria Scavasine, Renata Dal-Prá Ducci, Danielle C Mendes, Viviane de Hiroki Flumignan Zétola, Norberto Cabral, Tatjana Rundek
The aim of the study was to analyze the long-term recurrence rate in patients with a first-ever ischemic stroke secondary to intracranial large artery atherosclerosis (LAA) in a Brazilian population. METHODS: All stroke patients admitted to the hospital between October 2012 and September 2015 were evaluated. The stroke mechanism subtypes were classified as cardioembolism, LAA, small-vessel occlusion, other determined etiologies, and stroke of undetermined etiology. RESULTS: The 359 first-ever ischemic stroke patients were followed up for a mean time of 21...
October 2018: Arquivos de Neuro-psiquiatria
Ananto Ali Alhasyimi, Pinandi Sri Pudyani, Ikmal Hafizi
INTRODUCTION: The number of patients who seek orthodontic treatment that may have a history of tooth bleaching is increasing over the time. Bleaching may influence the decrease of the bond strength of orthodontic brackets. OBJECTIVE: To determine and prove the effect of mangosteen peel (MP) extract to reverse the reduced shear bond strength (SBS) of orthodontic brackets after bleaching. METHODS: A total of 150 maxillary first premolar teeth were randomly divided into 6 experimental groups as follow (n=25): negative-control (N: no bleaching), positive-control (P: bleaching + no treatment), and the treatment groups (bleaching + 10% sodium ascorbate (SA), 10% (MP-10), 20% (MP-20) and 40% (MP-40) MP extract gel)...
September 2018: Dental Press Journal of Orthodontics
Antonio Macedo, Marcela Leal da Cruz
We report a case of secondary urinary reconstruction of previously separated conjoined twins with exstrophic bladder and urinary incontinence. Patients were male and aged 13-year-old. Twin one had a history of failed enterocystoplasty that extruded and was visible like an exstrophic neobladder. He underwent a procedure to close bladder neck and reconfigure abdominal wall. After the procedure the patient developed a fistula that was treated, but it persisted and, for this reason, a catheterizable pouch was constructed and native bladder was discarded...
November 8, 2018: Einstein
Altair da Silva Costa, Paulo Rogerio Scordamaglio, Iunis Suzuki, Addy Lidvina Mejia Palomino, Marcia Jacomelli
OBJECTIVE: To describe indications, clinical outcomes and complications of flexible bronchoscopy. METHODS: A descriptive observational study of bronchoscopies performed at the endoscopy service of Hospital Israelita Albert Einstein . Demographic (age, gender and origin) and medical (indications and results of endoscopy and diagnostic tests, such as biopsy collection, lavage, cytology and culture) data were analyzed. Electronic medical records with incomplete data or reporting interventional procedures were excluded...
November 8, 2018: Einstein
Jaqueline Cristina da Silveira Xavier E Castro, Stephanie Ferreira Botelho, Taisa Roberta Lopes Machado, Maria Auxiliadora Parreiras Martins, Liliana Batista Vieira, Adriano Max Moreira Reis
OBJECTIVE: To analyze suitability of new drugs registered in Brazil from 2003 to 2013 for pediatric age groups. METHODS: A descriptive study of drugs with pediatric indication included in a retrospective cohort of new drugs registered in Brazil. The evaluation of drug suitability for the pediatric age group was performed using the following criteria: suitability of dosage form and capacity to deliver the recommended dose. The drugs were considered adequate for the pediatric age groups when they met both criteria...
November 8, 2018: Einstein
Andre Miotto, Pedro Augusto Antunes Honda, Thiago Gangi Bachichi, Caio Santos Holanda, Ernesto Evangelista Neto, João Alessio Juliano Perfeito, Luiz Eduardo Villaça Leão, Altair da Silva Costa
OBJECTIVE: To evaluate the difference in transepidermal water loss in patients diagnosed with hyperhidrosis and healthy subjects, in an air-conditioned environment. METHODS: Twenty patients diagnosed with hyperhidrosis and 20 healthy subjects were subjected to quantitative assessment using a closed-chamber device, in six previously established sites. RESULTS: The measurements showed different transepidermal water loss values for healthy subjects and patients with hyperhidrosis, especially in the hands and feet...
November 8, 2018: Einstein
Thelen Daiana Mendonça Ferreira, Luciana Dantas Piccioni, Patricia Helena Breno Queiroz, Eliete Maria Silva, Ianê Nogueira do Vale
OBJECTIVE: To evaluate the influence of grandmothers of infants on exclusive breastfeeding, from their perspective. METHODS: A descriptive cross-sectional study was carried out with 91 women from a hospital in the inland state of São Paulo. By means of a questionnaire, the following data were collected: sociodemographic data of the grandmother, mother and child; duration of exclusive breastfeeding of daughter or daughter-in-law; information on kinship of participant and grandchild; kind of help provided by grandmother; and knowledge about breastfeeding...
November 8, 2018: Einstein
Yahui Pan, Xiaodong Xu, Fangfang Sun, Xiangfeng Meng
The stable long-term performance of resin cement under oral environmental conditions is a crucial factor to obtain a satisfactory success of the allceramic dental restoration. OBJECTIVE: This study aimed at evaluating and comparing the surface morphology and mechanical property of conventional and self-adhesive resin cement after aqueous aging. MATERIALS AND METHODS: Disc-shaped specimens of 3 conventional (C1: Multilink N, C2: Duolink, C3: Nexus 3) and 3 self-adhesive (S1: Multilink Speed, S2: Biscem, S3: Maxcem) types of resin cements were subjected to irradiation...
November 8, 2018: Journal of Applied Oral Science: Revista FOB
Sandra Fiorelli de Almeida Penteado Simeão, Géssika Araujo de Lima Martins, Marcia Aparecida Nuevo Gatti, Marta Helena Souza De Conti, Alberto De Vitta, Sara Nader Marta
The aim of this study was to compare the QOL of the elderly living in nursing homes and those who attend the Day Center (Centro Dia) at the the Asilo Vila Vicentina in the city of Bauru/SP. The sample consisted of 48 subjects, 21 men, 5 from the Day Center and 16 nursing home residents, and 27 women, 16 from the Day Center and 11 nursing homes residents, who answered the following questionnaires: socio-demographic characteristics, WHOQOL-Old, and WHOQOL-Bref. The responses were submitted to descriptive and inferential statistics to compare the QOL scores of the nursing home residents with the elderly who attend the Day Center using the Mann Whitney test...
November 2018: Ciência & Saúde Coletiva
Eduardo José Pereira Oliveira, Denismar Alves Nogueira, Alessandro Aparecido Pereira
The aim of this study was to evaluate the relationship between the perception of dental care services and oral health conditions in a hypertensive and diabetic population subscribed to the Family Health Strategy in the city of Alfenas, Minas Gerais, Brazil. This was a domiciliary, descriptive-analytical study with random and stratified sample, consisting of 186 individuals. The following indexes were applied: Decayed, Missing and Filled Teeth (DMFT); Filled and Sound Teeth (FS-T); Dental Care Index (DCI); Evaluation of the use and need of dentures; Oral health for primary care assessment questionnaire (OHPCA)...
November 2018: Ciência & Saúde Coletiva
Nilva Lúcia Rech Stedile, Vania Elisabete Schneider, Monique Walltrick Nunes, Adriane Carine Kappes
The use of health indicators is indispensable for understanding the complex relationship between the environmental and health fields. For the proposition of environmental health indicators, the Brazilian Ministry of Health (MH) recommends using a model proposed by the World Health Organization. This model is composed of the following elements: Driving Force, Pressure, State, Exposure, Effect, and Action; it is called the DPSEEA model. The objective of this study is to propose the application of this model in healthcare waste (HCW) management...
November 2018: Ciência & Saúde Coletiva
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