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On October 30, 2013, OPM published final regulations in the Federal Register to expand coverage for children of same-sex domestic partners under the Federal Employees Health Benefits (FEHB) Program and the Federal Employees Dental and Vision Insurance Program (FEDVIP). The regulation allowed children of same-sex domestic partners living in states that did not allow same-sex couples to marry to be covered family members under the FEHB and the FEDVIP. Due to a subsequent Supreme Court decision legalizing same-sex marriage in all states, OPM published an interim final regulation on December 2, 2016, that created a regulatory exception that only allowed children of same-sex domestic partners living overseas to maintain their FEHB and FEDVIP coverage until September 30, 2018...
July 12, 2018: Federal Register
Mirelle Hanskamp-Sebregts, Paul H B Robben, Hub Wollersheim, Marieke Zegers
OBJECTIVE: To study to what extent internal audit results of hospitals can be shared with external supervisors and the necessary preconditions for this. DESIGN: Qualitative interview research. METHOD: In 2013-2015, we interviewed 36 individuals from six hospitals: 12 department heads (all medical specialists), 10 department managers; five members of the Board of Directors; five members of the Supervisory Board and the four account-holding hospital inspectors...
April 30, 2018: Nederlands Tijdschrift Voor Geneeskunde
Sabine L M Logtenberg, M L Vink, Marc Godfried, Ingrid C M Beenakkers, Liv M Freeman, François G Schellevis, Ben Willem Mol, Corine J Verhoeven
OBJECTIVE: To survey (a) the frequency of the use of patient-controlled analgesic remifentanil-PCA during labour in the Netherlands; (b) considerations by obstetricians whether or not to offer remifentanil-PCA; (c) target population for remifentanil-PCA and (d) the application of maternal monitoring. DESIGN: Descriptive survey. METHOD: A questionnaire was sent to all 81 Dutch hospitals with a labour ward. The following subjects were covered: (a) available methods for pharmacological pain relief; (b) considerations by obstetricians whether or not to offer remifentanil-PCA; (c) target population for remifentanil-PCA; (d) maternal monitoring and (e) the hospital's birth data for the year 2016...
May 1, 2018: Nederlands Tijdschrift Voor Geneeskunde
Carlos Roque Duarte Correia, Rafaela Costa Carmona, Otto Daolio Köster
Unprecedented enantioselective intramolecular Heck carbonylation reactions were achieved employing arenediazonium salts and N,N-chiral ligand. This methodology encompasses the first examples of an enantioselective Heck carbonylation through migratory insertion followed by CO insertion sequence. The enantioenriched functionalized dihydrobenzofurans were obtained in good to high yields and enantiomeric ratios up to 98:2 under mild and operationally simple reaction conditions.
July 18, 2018: Angewandte Chemie
Bruno Stankoff, Emilie Poirion, Matteo Tonietto, Benedetta Bodini
The biological mechanisms driving disability worsening in multiple sclerosis (MS) are only partly understood.. Monitoring changes in lesion load on MRI has a limited predictive value on the development of clinical disability, and there is an essential need for novel imaging markers specific for the main candidate mechanisms underlying neurodegeneration which include failing myelin repair, innate immune cell activation and grey matter neuronal damage. Positron Emission Tomography (PET) is an imaging technology based on the injection of radiotracers directed against specific molecular targets and has recently allowed the selective quantification in-vivo of the key biological mechanisms relevant to MS pathophysiology...
July 18, 2018: Brain Pathology
Chunhua Guo, Min Lei, Yong Wang, Limei Hua, Sujuan Xue, Dan Yu, Chunhua Zhang, Dawei Wang
Considerate proportion of elderly patients with a rib fracture is susceptible to pulmonary complications, especially pneumonia. We aimed to assess the effect of oral administration of the probiotic Lactobacillus casei Shirota (LcS) on pneumonia and pulmonary functions among elderly patients with single rib fracture. The current study including 204 eligible elderly patients with a single rib fracture was conducted. Patients were randomly assigned to receive oral administration of skimmed milk containing either a commercial probiotic LcS or placebo daily for 1 mo after the fracture, followed by pneumonia assessments, pulmonary function testing including forced expiratory volume (FEV), negative inspiratory pressure (NIP), and forced vital capacity (FVC), as well as evaluation of potential adverse effects including myocardial infarction, acute kidney injury, nonunion of fractured bone, or stroke...
July 18, 2018: Journal of Food Science
Burak Bahar, Stefan E Pambuccian, Güliz A Barkan, Yasemin Akdas
Background: The misuse of statistical methods in diagnostic accuracy studies has been criticized in many publications. Objective: To assess the use and misuse of statistical methods in medical journal articles. Methods: We reviewed 141 original articles from 6 cytopathology journals published in 2014. Results: In total, 16 articles used no descriptive statistics and 66 articles used no inferential statistics. Also, 82 articles did not report using any tests for diagnostic accuracy...
July 17, 2018: Laboratory Medicine
Katherine Hadlandsmyth, Kenda R Stewart, Monica B Paez, Melissa Steffen, Molly Meth, Heather Schacht Reisinger, Hilary J Mosher
Objective: To elucidate perspectives on opioids and opioid use from hospitalized veterans with comorbid chronic pain using qualitative methods. Design: This was an analysis of individual qualitative interviews. The semistructured interview guide was developed by a hospitalist with clinical expertise in pain treatment with guidance from a medical anthropologist. Interviews aimed to understand participants' experiences of chronic pain. Setting: A Midwestern Veterans Health Administration inpatient hospital unit...
July 17, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Johanna M Meulepas, Cécile M Ronckers, Anne M J B Smets, Rutger A J Nievelstein, Patrycja Gradowska, Choonsik Lee, Andreas Jahnen, Marcel van Straten, Marie-Claire Y de Wit, Bernard Zonnenberg, Willemijn M Klein, Johannes H Merks, Otto Visser, Flora E van Leeuwen, Michael Hauptmann
Background: Computed tomography (CT), a strong diagnostic tool, delivers higher radiation doses than most imaging modalities. As CT use has increased rapidly, radiation protection is important, particularly among children. We evaluate leukemia and brain tumor risk following exposure to low-dose ionizing radiation from CT scans in childhood. Methods: For a nationwide retrospective cohort of 168 394 children who received one or more CT scans in a Dutch hospital between 1979 and 2012 who were younger than age 18 years, we obtained cancer incidence, vital status, and confounder information by record linkage with external registries...
July 18, 2018: Journal of the National Cancer Institute
Sumaetee Tangwancharoen, Gary W Moy, Ronald S Burton
Thermal tolerance is a key determinant of species distribution. Despite much study, the genetic basis of adaptive evolution of thermal tolerance, including the relative contributions of transcriptional regulation versus protein evolution, remains unclear. Populations of the intertidal copepod Tigriopus californicus are adapted to local thermal regimes across their broad geographic range. Upon thermal stress, adults from a heat tolerant southern population (San Diego) upregulate several heat shock proteins (HSPs) to higher levels than those from a less tolerant northern population (Santa Cruz)...
July 18, 2018: Molecular Biology and Evolution
Qian Zhao, Wei Wang, Shuai Gao, Yeqing Sun
To investigate the mechanism underlying differences in biological effects induced by low- versus high-dose heavy-ion radiation (HIR) in rice plants, two-dimensional gel electrophoresis (2-DE) coupled with methylation-sensitive amplification polymorphism (MSAP) analysis were used to check the expression changes in rice leaf proteome profiles and the changes in DNA methylation after exposure of seeds to ground-based carbon-ion radiation at various cumulative doses (0, 0.01, 0.02, 0.1, 0.2, 1, 2, 5 or 20 Gy; 12C6+; energy, 165 MeV/u; mean linear energy transfer, 30 KeV/μm)...
July 18, 2018: Journal of Radiation Research
Maciej Skoracki, Martin Hromada, Mateusz Zmudzinski, Markus Unsoeld, Bozena Sikora
We investigated the quill mite fauna of the family Syringophilidae (Acariformes: Prostigmata) associated with Sunbirds (Passeriformes: Nectariniidae) in the Sub-Saharan region. Six hundred eleven host individuals belonging to 52 species were examined. Syringophilid parasitization prevalence (44 hosts of 15 species) ranged from 1.4 to 75% in particular host species. In the collected material, we have found seven quill mite species and among them four are new for science: 1) Aulobia afroanthreptes Skoracki & Zmudzinski sp...
July 18, 2018: Journal of Medical Entomology
Karlien Veldscholte, Mirjana Barjaktarovic, Katarina Trajanoska, Vincent W V Jaddoe, Theo J Visser, Yolanda B de Rijke, Robin P Peeters, Fernando Rivadeneira, Tim I M Korevaar
Context: Although the skeleton is a well-known thyroid hormone target organ, very little data are available on the association of thyroid function with bone outcomes during childhood. Objective: To study the association of thyroid function with bone mass during childhood. Design, setting and participants: Population-based prospective cohort including 4,204 children with TSH and FT4 measured at the age of 6 years. Main outcome measures: Bone density was assessed by a total body dual-energy x-ray absorptiometry (DXA) scan at the median age of 6 years (95% range 5...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Juliana Drummond, Federico Roncaroli, Ashley B Grossman, Márta Korbonits
Context: Silent pituitary adenomas are anterior pituitary tumors with hormone synthesis but without signs or symptoms of hormone hypersecretion. They have been increasingly recognized and represent challenging diagnostic issues. Evidence Acquisition: A comprehensive literature search was performed using MEDLINE and EMBASE databases between January 2000 and March 2018 with the following key words: (i) pituitary adenoma/tumor and non-functioning; or (ii) pituitary adenoma/tumor and silent...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Yu-Ichiro Nakajima
Polarized epithelia are a foundation of organ and appendage structures throughout Metazoa and serve as a physical barrier to preserve physiological functions. In proliferating epithelia, planar cell division occurs by orienting the mitotic spindle within the plane of the epithelium to ensure tissue organization. Conversely, loss of tissue architecture is a hallmark of carcinoma, and aberrant spindle orientation is hypothesized to contribute to tissue disorganization through dysplasia and cell dissemination...
July 18, 2018: Journal of Biochemistry
Jose A Rosa-Parra, Marcela Tamayo-Ortiz, Hector Lamadrid-Figueroa, Alejandra Cantoral-Preciado, Alejandra Montoya, Rosalind J Wright, Andrea A Baccarelli, Allan C Just, Katherine Svensson, Robert O Wright, Martha María Téllez-Rojo Solís
Context: Early life cortisol plays an important role in bone, muscle and fat mobilization processes, which could influence body composition, affecting anthropometric indicators like weight and height. Objective: To explore the association between diurnal cortisol levels and growth indexes in children from 12 to 48 months of age. Design: This study includes data of 404 children from the PROGRESS Mexican birth cohort. Cortisol was measured in 8 saliva samples collected at 4 time points during the day (from wake-up to bed time), over 2 days, when the child was either 12, 18 or 24 months old...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Hanh H Nguyen, Phillip Wong, Boyd J Strauss, Peter R Ebeling, Frances Milat, Amanda Vincent
Context: Turner Syndrome (TS) is associated with short stature, gonadal failure, and fractures. Spinal trabecular bone score (TBS) is a novel bone imaging modality that has not been evaluated in TS. Objective: To evaluate TBS in TS, and its association with BMD, prevalent fracture and its risk factors. Design and setting: Longitudinal study of TS from a single tertiary hospital between 2006-2017. Patients or Other Participants: Fifty-eight TS subjects aged 20-49 years who underwent DXA...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Lara Khadr, Manale Harfouche, Ryosuke Omori, Guido Schwarzer, Hiam Chemaitelly, Laith J Abu-Raddad
Objective: To characterize herpes simplex virus type 1 (HSV-1) epidemiology in Asia by assessing seroprevalence levels and extent to which HSV-1 is isolated from clinically-diagnosed genital ulcer disease (GUD) and genital herpes. Methods: HSV-1 reports in Asia were systematically reviewed and synthesized, and findings reported following PRISMA guidelines. Random-effects meta-analyses were conducted to estimate pooled mean seroprevalence and proportion of HSV-1 detection in GUD and genital herpes...
July 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Ahmed Ghazy, Rayan Chaban, Christian-Friedrich Vahl, Bernhard Dorweiler
OBJECTIVES: Training and assessment of proper skills in flexible bronchoscopy are major educational goals for cardiothoracic residents. Therefore, we developed 3-dimensional (3D) printed models of the human tracheobronchial system for training and assessment of cardiothoracic residents in flexible bronchoscopy. METHODS: Three models of normal (size/shape) human tracheobronchial anatomy were generated using a commercially available 3D printer. Ten residents (inexperienced: Group 1; experienced: Group 2) participated in this study with an experimental setting of initial assessment (Model 1), training (15 min, Model 2) and post-training assessment (Model 3)...
July 17, 2018: Interactive Cardiovascular and Thoracic Surgery
Paul N Newton, Valy Keolouangkhot, Sue J Lee, Khamla Choumlivong, Siho Sisouphone, Khamloune Choumlivong, Manivanh Vongsouvath, Mayfong Mayxay, Vilada Chansamouth, Viengmon Davong, Koukeo Phommasone, Joy Sirisouk, Stuart D Blacksell, Pruksa Nawtaisong, Catrin E Moore, Josée Castonguay-Vanier, Sabine Dittrich, Sayaphet Rattanavong, Ko Chang, Chirapha Darasavath, Oudayvone Rattanavong, Daniel H Paris, Rattanaphone Phetsouvanh
Background: Murine typhus, or infection with Rickettsia typhi, is a global but neglected disease without randomised clinical trials to guide antibiotic therapy. Doxycycline is commonly used but without objective evidence for optimum treatment duration. Azithromycin is a potential alternative. Methods: A prospective, open, randomised trial was conducted in non-pregnant, consenting inpatient adults with rapid diagnostic test evidence for uncomplicated murine typhus at two hospitals in Vientiane, Laos...
July 18, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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