keyword
https://read.qxmd.com/read/37293574/enhancing-hepatic-mboat7-expression-in-mice-with-nonalcoholic-steatohepatitis
#21
JOURNAL ARTICLE
Martin C Sharpe, Kelly D Pyles, Taylor Hallcox, Dakota R Kamm, Michaela Piechowski, Bryan Fisk, Carolyn J Albert, Danielle H Carpenter, Barbara Ulmasov, David A Ford, Brent A Neuschwander-Tetri, Kyle S McCommis
BACKGROUND AND AIMS: Polymorphisms near the membrane bound O-acyltransferase domain containing 7 (MBOAT7) genes are associated with worsened nonalcoholic fatty liver (NASH), and nonalcoholic fatty liver disease (NAFLD)/NASH may decrease MBOAT7 expression independent of these polymorphisms. We hypothesized that enhancing MBOAT7 function would improve NASH. METHODS: Genomic and lipidomic databases were mined for MBOAT7 expression and hepatic phosphatidylinositol (PI) abundance in human NAFLD/NASH...
2023: Gastro Hep Adv
https://read.qxmd.com/read/37176603/warm-ischemia-induces-spatiotemporal-changes-in-lysophosphatidylinositol-that-affect-post-reperfusion-injury-in-normal-and-steatotic-rat-livers
#22
JOURNAL ARTICLE
Kengo Shibata, Takahiro Hayasaka, Sodai Sakamoto, Satsuki Hashimoto, Norio Kawamura, Masato Fujiyoshi, Taichi Kimura, Tsuyoshi Shimamura, Moto Fukai, Akinobu Taketomi
Warm ischemia-reperfusion injury is a prognostic factor for hepatectomy and liver transplantation. However, its underlying molecular mechanisms are unknown. This study aimed to elucidate these mechanisms and identify the predictive markers of post-reperfusion injury. Rats with normal livers were subjected to 70% hepatic warm ischemia for 15, 30, or 90 min, while those with steatotic livers were subjected to 70% hepatic warm ischemia for only 30 min. The liver and blood were sampled at the end of ischemia and 1, 6, and 24 h after reperfusion...
April 27, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37072179/serum-lipidome-unravels-a-diagnostic-potential-in-bile-acid-diarrhoea
#23
JOURNAL ARTICLE
Monika Lewinska, Martin Lund Kårhus, Anne-Marie Gade Ellegaard, Manuel Romero-Gómez, Rocio I R Macias, Jesper B Andersen, Filip Krag Knop
OBJECTIVE: Bile acid diarrhoea (BAD) is debilitating yet treatable, but it remains underdiagnosed due to challenging diagnostics. We developed a blood test-based method to guide BAD diagnosis. DESIGN: We included serum from 50 treatment-naive patients with BAD diagnosed by gold standard 75 selenium homotaurocholic acid test, 56 feature-matched controls and 37 patients with non-alcoholic fatty liver disease (NAFLD). Metabolomes were generated using mass spectrometry covering 1295 metabolites and compared between groups...
April 18, 2023: Gut
https://read.qxmd.com/read/37061204/lysophospholipids-and-their-producing-enzymes-their-pathological-roles-and-potential-as-pathological-biomarkers
#24
REVIEW
Shun Yaginuma, Jumpei Omi, Kuniyuki Kano, Junken Aoki
Accumulating evidence suggests that lysophospholipids (LPL) serve as lipid mediators that exert their diverse pathophysiological functions via G protein-coupled receptors. These include lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), lysophosphatidylserine (LysoPS) and lysophosphatidylinositol (LPI). Unlike S1P, which is produced intracellularly and secreted from various cell types, some LPLs, such as LPA, LysoPS and LPI, are produced in lesions, especially under pathological conditions, where they positively or negatively regulate disease progression through their autacoid-like actions...
April 13, 2023: Pharmacology & Therapeutics
https://read.qxmd.com/read/37047288/lysophosphatidylinositol-promotes-chemotaxis-and-cytokine-synthesis-in-mast-cells-with-differential-participation-of-gpr55-and-cb2-receptors
#25
JOURNAL ARTICLE
Lizbeth Magnolia Martínez-Aguilar, Alfredo Ibarra-Sánchez, Daniel José Guerrero-Morán, Marina Macías-Silva, Jesús Omar Muñoz-Bello, Alejandro Padilla, Marcela Lizano, Claudia González-Espinosa
Mast cells (MCs) are the main participants in the control of immune reactions associated with inflammation, allergies, defense against pathogens, and tumor growth. Bioactive lipids are lipophilic compounds able to modulate MC activation. Here, we explored some of the effects of the bioactive lipid lysophosphatidylinositol (LPI) on MCs. Utilizing murine bone marrow-derived mast cells (BMMCs), we found that LPI did not cause degranulation, but slightly increased FcεRI-dependent β-hexosaminidase release...
March 28, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37036835/emerging-roles-of-lysophosphatidylserine-as-an-immune-modulator
#26
REVIEW
Shun Yaginuma, Jumpei Omi, Akiharu Uwamizu, Junken Aoki
In addition to direct activation by pathogens and antigens, immune cell functions are further modulated by factors in their environment. Recent studies have revealed that lysophospholipids (LPL) derived from membrane glycerophospholipids are such environmental factors. They are produced by the action of various phospholipases and modulate immune responses positively or negatively via G-protein-coupled receptor-type receptors. These include lysophosphatidic acid, lysophosphatidylserine (LysoPS), and lysophosphatidylinositol...
April 10, 2023: Immunological Reviews
https://read.qxmd.com/read/37026387/cotton-peroxisome-localized-lysophospholipase-counteracts-the-toxic-effects-of-verticillium-dahliae-nlp1-and-confers-wilt-resistance
#27
JOURNAL ARTICLE
Guilin Wang, Xinyu Wang, Jian Song, Haitang Wang, Chaofeng Ruan, Wenshu Zhang, Zhan Guo, Weixi Li, Wangzhen Guo
Plasma membrane represents a critical battleground between plants and attacking microbes. Necrosis and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs), cytolytic toxins produced by some bacterial, fungal and oomycete species, are able to target on lipid membranes by binding eudicot plant-specific sphingolipids (GIPC, glycosylinositol phosphorylceramide) and form transient small pores, causing membrane leakage and subsequent cell death. NLP-producing phytopathogens are big threat to agriculture worldwide...
April 7, 2023: Plant Journal
https://read.qxmd.com/read/36992523/integrative-analysis-of-transcriptomic-and-metabolomic-profiles-reveals-abnormal-phosphatidylinositol-metabolism-in-follicles-from-endometriosis-associated-infertility-patients
#28
JOURNAL ARTICLE
Yongdong Dai, Xiang Lin, Na Liu, Libing Shi, Feng Zhuo, Qianmeng Huang, Weijia Gu, Fanxuan Zhao, Yi Zhang, Yinli Zhang, Yinbin Pan, Songying Zhang
Endometriosis is a common gynecological disorder that causes female infertility. Our recent research found that excessive oxidative stress in ovaries of endometriosis patients induced senescence of cumulus granulosa cells. Here, we analyzed the transcriptomic and metabolomics profiles of follicles in a mouse model of endometriosis and in patients with endometriosis and investigated the potential function of changed metabolites in granulosa cells. RNA-sequencing indicated that both endometriosis lesions and oxidative stress in mice induced abnormalities of reactive oxidative stress, steroid hormone biosynthesis, and lipid metabolism...
March 29, 2023: Journal of Pathology
https://read.qxmd.com/read/36939788/plasma-lipidomic-subclasses-and-risk-of-hypertension-in-middle-aged-and-elderly-chinese
#29
JOURNAL ARTICLE
Zhenhua Niu, Qingqing Wu, Yaogan Luo, Di Wang, He Zheng, Yanpu Wu, Xiaowei Yang, Rong Zeng, Liang Sun, Xu Lin
UNLABELLED: While disrupted lipid metabolism is a well-established risk factor for hypertension in animal models, the links between various lipidomic signatures and hypertension in human studies remain unclear. We aimed to examine associations between plasma lipidomic profiles and prevalence of hypertension among 2248 community-living Chinese aged 50-70 years. Hypertension was defined according to 2020 International Society of Hypertension global hypertension practice guidelines and 2018 Chinese guidelines...
October 2022: Phenomics
https://read.qxmd.com/read/36847607/saturated-fatty-acids-increase-lpi-to-reduce-fundc1-dimerization-and-stability-and-mitochondrial-function
#30
JOURNAL ARTICLE
Linbo Chen, Qianping Zhang, Yuanyuan Meng, Tian Zhao, Chenglong Mu, Changying Fu, Caijuan Deng, Jianyu Feng, Siling Du, Wei Liu, Guangfeng Geng, Kaili Ma, Hongcheng Cheng, Qiangqiang Liu, Qian Luo, Jiaojiao Zhang, Zhanqiang Du, Lin Cao, Hui Wang, Yong Liu, Jianping Lin, Guo Chen, Lei Liu, Sin Man Lam, Guanghou Shui, Yushan Zhu, Quan Chen
Ectopic lipid deposition and mitochondrial dysfunction are common etiologies of obesity and metabolic disorders. Excessive dietary uptake of saturated fatty acids (SFAs) causes mitochondrial dysfunction and metabolic disorders, while unsaturated fatty acids (UFAs) counterbalance these detrimental effects. It remains elusive how SFAs and UFAs differentially signal toward mitochondria for mitochondrial performance. We report here that saturated dietary fatty acids such as palmitic acid (PA), but not unsaturated oleic acid (OA), increase lysophosphatidylinositol (LPI) production to impact on the stability of the mitophagy receptor FUNDC1 and on mitochondrial quality...
February 27, 2023: EMBO Reports
https://read.qxmd.com/read/36806709/mboat7-driven-lysophosphatidylinositol-acylation-in-adipocytes-contributes-to-systemic-glucose-homeostasis
#31
JOURNAL ARTICLE
William J Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L Brown, Anthony J Horak, Rachel C Hohe, Bryan M Jung, Yunguang Qiu, E Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S Allende, Belinda Willard, Feixiong Cheng, Aldons J Lusis, J Mark Brown
We previously demonstrated that antisense oligonucleotide (ASO)-mediated knockdown of Mboat7, the gene encoding Membrane Bound O-Acyltransferase 7, in the liver and adipose tissue of mice promoted high fat diet-induced hepatic steatosis, hyperinsulinemia, and systemic insulin resistance. Thereafter, other groups showed that hepatocyte-specific genetic deletion of Mboat7 promoted striking fatty liver and NAFLD progression in mice but does not alter insulin sensitivity, suggesting the potential for cell autonomous roles...
February 18, 2023: Journal of Lipid Research
https://read.qxmd.com/read/36787750/cannabidiol-modulates-excitatory-inhibitory-ratio-to-counter-hippocampal-hyperactivity
#32
JOURNAL ARTICLE
Evan C Rosenberg, Simon Chamberland, Michael Bazelot, Erica R Nebet, Xiaohan Wang, Sam McKenzie, Swati Jain, Stuart Greenhill, Max Wilson, Nicole Marley, Alejandro Salah, Shanice Bailey, Pabitra Hriday Patra, Rebecca Rose, Nicolas Chenouard, Simón E D Sun, Drew Jones, György Buzsáki, Orrin Devinsky, Gavin Woodhall, Helen E Scharfman, Benjamin J Whalley, Richard W Tsien
Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in multiple forms of pediatric epilepsies, but the mechanism(s) of anti-seizure action remain unclear. In one leading model, CBD acts at glutamatergic axon terminals, blocking the pro-excitatory actions of an endogenous membrane phospholipid, lysophosphatidylinositol (LPI), at the G-protein-coupled receptor GPR55. However, the impact of LPI-GPR55 signaling at inhibitory synapses and in epileptogenesis remains underexplored. We found that LPI transiently increased hippocampal CA3-CA1 excitatory presynaptic release probability and evoked synaptic strength in WT mice, while attenuating inhibitory postsynaptic strength by decreasing GABAA Rγ2 and gephyrin puncta...
April 19, 2023: Neuron
https://read.qxmd.com/read/36774102/diet-patterns-are-associated-with-circulating-metabolites-and-lipid-profiles-of-south-asians-in-the-united-states
#33
JOURNAL ARTICLE
Meghana D Gadgil, Alka M Kanaya, Caroline Sands, Elena Chekmeneva, Matthew R Lewis, Namratha R Kandula, David M Herrington
BACKGROUND: South Asians are at higher risk for cardiometabolic disease than many other racial/ethnic minority groups. Diet patterns in US South Asians have unique components associated with cardiometabolic disease. OBJECTIVES: We aimed to characterize the metabolites associated with 3 representative diet patterns. METHODS: We included 722 participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort study aged 40-84 y without known cardiovascular disease...
November 2022: Journal of Nutrition
https://read.qxmd.com/read/36697617/supercritical-fluid-chromatography-mass-spectrometry-enables-simultaneous-measurement-of-all-phosphoinositide-regioisomers
#34
JOURNAL ARTICLE
Yuta Shimanaka, Keiko Matsumoto, Yuki Tanaka, Yuki Ishino, Shenwei Ni, Jun-Lin Guan, Hiroyuki Arai, Nozomu Kono
Phosphoinositide species, differing in phosphorylation at hydroxyls of the inositol head group, play roles in various cellular events. Despite the importance of phosphoinositides, simultaneous quantification of individual phosphoinositide species is difficult using conventional methods. Here we developed a supercritical fluid chromatography-mass spectrometry method that can quantify the molecular species of all seven phosphoinositide regioisomers. We used this method to analyze (1) profiles of phosphoinositide species in mouse tissues, (2) the effect of lysophosphatidylinositol acyltransferase 1-depletion on phosphoinositide acyl-chain composition in cultured cells, and (3) the molecular species of phosphatidylinositol-3-phosphate produced during the induction of autophagy...
May 11, 2022: Communications Chemistry
https://read.qxmd.com/read/36674922/hepatitis-c-virus-infection-upregulates-plasma-phosphosphingolipids-and-endocannabinoids-and-downregulates-lysophosphoinositols
#35
JOURNAL ARTICLE
Diren Beyoğlu, Stephanie Schwalm, Nasser Semmo, Andrea Huwiler, Jeffrey R Idle
A mass spectrometry-based lipidomic investigation of 30 patients with chronic hepatitis C virus (HCV) infection and 30 age- and sex-matched healthy blood donor controls was undertaken. The clustering and complete separation of these two groups was found by both unsupervised and supervised multivariate data analyses. Three patients who had spontaneously cleared the virus and three who were successfully treated with direct-acting antiviral drugs remained within the HCV-positive metabotype, suggesting that the metabolic effects of HCV may be longer-lived...
January 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36634911/hepatic-effect-of-subacute-fe-2-o-3-nanoparticles-exposure-in-sprague-dawley-rats-by-lc-ms-ms-based-lipidomics
#36
JOURNAL ARTICLE
Dongxia Ren, Huangfang Shao, Yang Liu, Xue Wang, Yulin Li, Yun Li
Fe2 O3 nanoparticles (Fe2 O3 NPs) are one of the components of food additives numbered E172 and have been widely used as food pigments to color sweets. Although there were a large number of studies have reported that Fe2 O3 NPs could induce hepatotoxicity, the pathogenesis is still unclear, especially the subacute effects on the metabolic network after oral exposure. Therefore, it is necessary to conduct a highly sensitive strategy to investigate the potential effects and their mechanism of Fe2 O3 NPs. In this study, animal experiment showed that Fe2 O3 NPs had no obvious toxic effects on body weight, histopathological inspection and oxide stress...
January 12, 2023: Biomedical Chromatography: BMC
https://read.qxmd.com/read/36610088/comparison-of-glycerophospholipid-and-sphingolipid-in-mature-milk-from-different-sampled-regions-in-the-chinese-human-milk-project-chmp-study
#37
JOURNAL ARTICLE
Huiquan Zhu, Xiaodan Wang, Wenyuan Zhang, Jianchun Pan, Yumen Zhang, Yunna Wang, Chuqi Jiang, Qiaosi Wei, Xin Si, Shilong Jiang, Jing Lu, Jiaping Lv
Milk phospholipids (PLs) are critical components of infant growth. This study aimed to discover PL in mature human milk (HM) from China (n = 201) and mainly assessed the effect caused by sampled regions. The average total PL concentration was quantified from 3.65 to 11.25 mg per g of lipid, and the major PL class identified was sphingomyelin (SM, 38.06-47.62 %), followed by phosphatidylcholine (PC, 29.61-34.39 %), and phosphatidylethanolamine (PE, 10.54-24.46 %). In addition, the 36:2 (18:0/18:2), 38:6 (16:0/22:6), 40:1 (d18:1/22:0), and 42:2 (d18:1/24:1) were the most abundant molecular species identified in glycerophospholipid and SM molecular species respectively...
December 24, 2022: Food Chemistry
https://read.qxmd.com/read/36570536/modulations-of-bioactive-lipids-and-their-receptors-in-postmortem-alzheimer-s-disease-brains
#38
JOURNAL ARTICLE
Makoto Kurano, Yuko Saito, Baasanjav Uranbileg, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Yutaka Yatomi
BACKGROUND: Analyses of brain samples from Alzheimer's disease (AD) patients may be expected to help us improve our understanding of the pathogenesis of AD. Bioactive lipids, including sphingolipids, glycerophospholipids, and eicosanoids/related mediators have been demonstrated to exert potent physiological actions and to be involved in the pathogenesis of various human diseases. In this cross-sectional study, we attempted to elucidate the associations of these bioactive lipids with the pathogenesis/pathology of AD through postmortem studies of human brains...
2022: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36554419/serum-phospholipids-are-potential-therapeutic-targets-of-aqueous-extracts-of-roselle-hibiscus-sabdariffa-against-obesity-and-insulin-resistance
#39
JOURNAL ARTICLE
Carmen Alejandra Rangel-García, Rosalía Reynoso-Camacho, Iza F Pérez-Ramírez, Elizabeth Morales-Luna, Ericka A de Los Ríos, Luis M Salgado
Roselle ( Hibiscus sabdariffa ) is rich in phenolic compounds with antiobesogenic and antidiabetic effects. In this study, the effects of aqueous extracts of two varieties of Hibiscus sabdariffa , Alma blanca (white-yellow color) and Cuarenteña (purple color), were evaluated for the prevention of obesity and insulin resistance in rats fed a high-fat and high-fructose diet (HFFD), identifying targeted molecules through global metabolomics. After sixteen weeks, both roselle aqueous extracts prevented body weight gain, and white roselle extract ameliorated insulin resistance and decreased serum free fatty acid levels...
December 9, 2022: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36536251/apolipoprotein-d-modulates-lipid-mediators-and-osteopontin-in-an-anti-inflammatory-direction
#40
JOURNAL ARTICLE
Makoto Kurano, Kazuhisa Tsukamoto, Shigeo Kamitsuji, Naoyuki Kamatani, Koji Hasegawa, Masumi Hara, Toshio Ishikawa, Yutaka Yatomi, Tamio Teramoto
BACKGROUND: HDL has been proposed to possess anti-inflammatory properties; however, the detail mechanisms have not been fully elucidated. METHODS: We investigated the roles of Apolipoprotein D (ApoD) in the pathogenesis of inflammation in the mouse model of diet-induced obesity and that of lipopolysaccharide-induced sepsis and the in vitro experiments. Furthermore, we analyzed serum ApoD levels in human subjects. RESULTS: The overexpression of human ApoD decreased the plasma IL-6 and TNF-a levels in both mice models...
December 19, 2022: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
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