keyword
https://read.qxmd.com/read/38396948/the-interaction-of-the-endocannabinoid-anandamide-and-paracannabinoid-lysophosphatidylinositol-during-cell-death-induction-in-human-breast-cancer-cells
#1
JOURNAL ARTICLE
Mikhail G Akimov, Natalia M Gretskaya, Evgenia I Gorbacheva, Nisreen Khadour, Valeria S Chernavskaya, Galina D Sherstyanykh, Tatiana F Kovaleko, Elena V Fomina-Ageeva, Vladimir V Bezuglov
Endocannabinoid anandamide (AEA) and paracannabinoid lysophosphatidylinositol (LPI) play a significant role in cancer cell proliferation regulation. While anandamide inhibits the proliferation of cancer cells, LPI is known as a cancer stimulant. Despite the known endocannabinoid receptor crosstalk and simultaneous presence in the cancer microenvironment of both molecules, their combined activity has never been studied. We evaluated the effect of LPI on the AEA activity in six human breast cancer cell lines of different carcinogenicity (MCF-10A, MCF-7, BT-474, BT-20, SK-BR-3, MDA-MB-231) using resazurin and LDH tests after a 72 h incubation...
February 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38346769/genetic-and-biochemical-analysis-of-severe-hypertriglyceridemia-complicated-with-acute-pancreatitis-or-with-low-post-heparin-lipoprotein-lipase-mass
#2
JOURNAL ARTICLE
Takashi Suzuki, Makoto Kurano, Akari Isono, Takuya Uchino, Yohei Sayama, Honami Tomomitsu, Daiki Mayumi, Ruriko Shibayama, Toru Sekiguchi, Naoki Edo, Kiyoko Uno-Eder, Kenji Uno, Koji Morita, Toshio Ishikawa, Kazuhisa Tsukamoto
Severe hypertriglyceridemia is a pathological condition caused by genetic factors alone or in combination with environmental factors, sometimes leading to acute pancreatitis (AP). In this study, exome sequencing and biochemical analyses were performed in 4 patients with hypertriglyceridemia complicated by obesity or diabetes with a history of AP or decreased post-heparin LPL mass. In a patient with a history of AP, SNP rs199953320 resulting in LMF1 nonsense mutation and APOE rs7412 causing apolipoprotein E2 were both found in heterozygous form...
February 9, 2024: Endocrine Journal
https://read.qxmd.com/read/38342417/metabolic-phenotyping-and-global-functional-analysis-facilitate-metabolic-signature-discovery-for-tuberculosis-treatment-monitoring
#3
JOURNAL ARTICLE
Nguyen Ky Anh, Nguyen Thi Hai Yen, Nguyen Tran Nam Tien, Nguyen Ky Phat, Young Jin Park, Ho-Sook Kim, Dinh Hoa Vu, Jee Youn Oh, Dong Hyun Kim, Nguyen Phuoc Long
Tracking alterations in polar metabolite and lipid levels during anti-tuberculosis (TB) interventions is an emerging biomarker discovery and validation approach due to its sensitivity in capturing changes and reflecting on the host status. Here, we employed deep plasma metabolic phenotyping to explore the TB patient metabolome during three phases of treatment: at baseline, during intensive phase treatment, and upon treatment completion. Differential metabolites (DMs) in each period were determined, and the pathway-level biological changes were explored by untargeted metabolomics-guided functional interpretations that bypassed identification...
February 9, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38306852/altered-ovarian-tissue-level-of-lysophosphatidic-acid-and-mrna-expressions-of-its-metabolic-enzymes-and-receptors-in-rats-received-gonadotropin-hyperstimulation
#4
JOURNAL ARTICLE
Aimi Yamamoto-Mikami, Yu Tanaka, Toshihiko Tsutsumi, Akira Kuwahara, Akira Tokumura
Lysophosphatidic acid (LPA), a well-studied member of the lysophospholipid family, is known to exert an important bio-effect on oocyte maturation and ovulation in mammals. We attempted to determine how follicle maturation in the rat ovary affects the levels of LPA and its precursor lysophospholipids, as well as mRNA levels of LPA-producing and -degrading enzymes and LPA receptors in rats that received gonadotropin-hyper-stimulation. Tissue levels of lysophospholipids were quantified by LC-MS/MS, and relative mRNA expression levels of LPA-producing and -degrading enzymes, and LPA receptors were measured by RT-PCR...
February 1, 2024: Reproductive Biology
https://read.qxmd.com/read/38194811/intestinal-microbiota-promoted-nionps-induced-liver-fibrosis-via-effecting-serum-metabolism
#5
JOURNAL ARTICLE
Jiarong Tang, Hongjun Zhao, Kun Li, Haodong Zhou, Qingyang Chen, Hui Wang, Sheng Li, Jianguang Xu, Yingbiao Sun, Xuhong Chang
Nickel oxide nanoparticles (NiONPs) are toxic heavy metal compounds that induce liver fibrosis and metabolic disorders. Current research shows that the intestinal microbiota regulates liver metabolism through the gut-liver axis. However, it is unclear whether NiONPs affect the intestinal microbiota and the relationship between microbiota and liver metabolic disorders. Therefore, in this study, we established liver fibrosis model by administering 0.015, 0.06 and 0.24 mg/mL NiONPs through tracheal instillation twice a week for 9 weeks in rats, then we collected serum and fecal sample for whole metabolomics and metagenomic sequencing...
January 8, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/37986503/revealing-the-dynamic-changes-of-lipids-in-coffee-beans-during-roasting-based-on-uhplc-qe-hr-am-ms-ms
#6
JOURNAL ARTICLE
Jinrui Zhu, Li Zhou, Minjie Zhao, Fang Wei, Haiyan Fu, Eric Marchioni
Coffee is popular worldwide and its consumption is increasing in recent years. Although mass spectrometry-based lipidomics approaches have been prevalent, their application in studies related to detailed information and dynamic changes in lipid composition during coffee bean roasting is still limited. The aim of this study was to investigate the dynamic changes in coffee bean lipids during the roasting process. The lipid classes and lipid molecular species in coffee beans were characterized by lipidomic analysis combined with chemometrics...
December 2023: Food Research International
https://read.qxmd.com/read/37900123/qushi-huayu-decoction-ameliorates-non-alcoholic-fatty-liver-disease-in-rats-by-modulating-gut-microbiota-and-serum-lipids
#7
JOURNAL ARTICLE
Yiming Ni, Xin Wang, Qian Wu, Yichen Yao, Yuan Xu, Yuanyuan Li, Qin Feng, Mingmei Zhou, Xiaojun Gou
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease. As a clinical empirical prescription of traditional Chinese medicine, Qushi Huayu decoction (QHD) has attracted considerable attention for its advantages in multi-target treatment of NAFLD. However, the intervention mechanism of QHD on abnormal lipid levels and gut microbiota in NAFLD has not been reported. METHODS: Therefore, we verified the therapeutic effect of QHD on high-fat diet (HFD)-induced NAFLD in rats by physiological parameters and histopathological examination...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37866808/modulation-of-pi3k-akt-gsk3%C3%AE-signaling-cascade-through-g-protein-coupled-receptor-55-gpr55-activation-prenatal-lysophosphatidylinositol-attenuates-valproic-acid-induced-synaptic-abnormalities-and-mitochondrial-dysfunction
#8
JOURNAL ARTICLE
Shamim Ahmed, Ariful Haque Abir, Ozayra Sharmin, Neda Khurshid, Amana Akter, Nafisa Tajneen Nakshy, Md Mahmudul Hasan, Saquiba Yesmine, Mahbubur Rahman
AIMS: Dysregulation of PI3K/Akt/GSK3β signaling has been implicated in various neurological disorders, including autism spectrum disorder (ASD). G protein-coupled receptor 55 (GPR55) has recently emerged as a potential regulator of this signaling cascade. This study explores the intricate modulation of the PI3K/Akt/GSK3β signaling cascade via GPR55 activation and its potential therapeutic implications in the context of autism-associated neuronal impairments. MAIN METHODS: Valproic acid (VPA) was administered on embryonic day 12 (E12) to induce ASD, and lysophosphatidylinositol (LPI), a GPR55 agonist, was used prenatally to modulate the receptor activity...
October 20, 2023: Life Sciences
https://read.qxmd.com/read/37862465/lysophosphotidylinositols-lysopis-are-upregulated-following-human-%C3%A3-cell-loss-and-act-to-potentiate-insulin-release
#9
JOURNAL ARTICLE
Cecilia Jiménez-Sánchez, Flore Sinturel, Teresa Mezza, Ursula Loizides-Mangold, Jonathan Paz Montoya, Lingzi Li, Gianfranco Di Giuseppe, Giuseppe Quero, Idris Guessous, François Jornayvaz, Patrick Schrauwen, Dirk Jan Stenvers, Sergio Alfieri, Andrea Giaccari, Ekaterine Berishvili, Philippe Compagnon, Domenico Bosco, Howard Riezman, Charna Dibner, Pierre Maechler
In this study, we identified new lipid species associated with the loss of pancreatic ß-cells triggering diabetes. We performed lipidomics measurements on serum from prediabetic mice lacking ß-cell prohibititin-2 (ß-Phb2-/-, a model of monogenic diabetes), in patients without previous history of diabetes but scheduled for pancreaticoduodenectomy resulting in the acute reduction of their ß-cell mass (about 50%), and in patients with type 2 diabetes. We found higher lysophosphatidylinositols (LysoPIs) as the main circulating lipid species altered in prediabetic mice...
October 20, 2023: Diabetes
https://read.qxmd.com/read/37808828/membrane-bound-o-acyltransferase-7-mboat7-shapes-lysosomal-lipid-homeostasis-and-function-to-control-alcohol-associated-liver-injury
#10
Venkateshwari Varadharajan, Lyappan Ramachandiran, William J Massey, Raghav Jain, Rakhee Banerjee, Anthony J Horak, Megan R McMullen, Emily Huang, Annette Bellar, Shuhui W Lorkowski, Kailash Guilshan, Robert N Helsley, Isabella James, Vai Pathak, Jaividhya Dasarathy, Nicole Welch, Srinivasan Dasarathy, David Streem, Ofer Reizes, Daniela S Allende, Jonathan D Smith, Judith Simcox, Laura E Nagy, J Mark Brown
Several recent genome-wide association studies (GWAS) have identified single nucleotide polymorphism (SNPs) near the gene encoding membrane-bound O -acyltransferase 7 ( MBOAT7 ) that is associated with advanced liver diseases. In fact, a common MBOAT7 variant (rs641738), which is associated with reduced MBOAT7 expression, confers increased susceptibility to non-alcoholic fatty liver disease (NAFLD), alcohol-associated liver disease (ALD), and liver fibrosis in those chronically infected with hepatitis viruses B and C...
September 27, 2023: bioRxiv
https://read.qxmd.com/read/37772396/metabolomics-analyses-of-cancer-tissue-from-patients-with-colorectal-cancer
#11
JOURNAL ARTICLE
Chunbo Kang, Jie Zhang, Mei Xue, Xiaowei Li, Danyang Ding, Ye Wang, Shujing Jiang, Fong-Fong Chu, Qiang Gao, Mengqiao Zhang
The alteration of metabolism is essential for the initiation and progression of numerous types of cancer, including colorectal cancer (CRC). Metabolomics has been used to study CRC. At present, the reprogramming of the metabolism in CRC remains to be fully elucidated. In the present study, comprehensive untargeted metabolomics analysis was performed on the paired CRC tissues and adjacent normal tissues from patients with CRC (n=35) using ultra‑high‑performance liquid chromatography‑mass spectrometry...
November 2023: Molecular Medicine Reports
https://read.qxmd.com/read/37716533/restoring-prefrontal-cortical-excitation-inhibition-balance-with-cannabidiol-ameliorates-neurobehavioral-abnormalities-in-a-mouse-model-of-neurodevelopmental-disorders
#12
JOURNAL ARTICLE
Lu Zhang, Chunqiao Lin, Jiushuang Zhu, Yan He, Meng Zhan, Xiuwen Xia, Ni Yang, Kun Yang, Baojia Wang, Zhanqion Zhong, Yili Wang, Weijun Ding, Youjun Yang
Maternal immune activation (MIA) resulting from viral infections during pregnancy is linked to increased rates of neurodevelopmental disorders in offspring. However, the mechanisms underlying MIA-induced neurobehavioral abnormalities remain unclear. Here, we used a poly (I:C)-induced MIA mouse model to demonstrate the presence of multiple behavioral deficits in male offspring. Through RNA sequencing (RNA-seq), we identified significant upregulation of genes involved in axonogenesis, synaptogenesis, and glutamatergic synaptic neurotransmission in the mPFC of MIA mice...
September 14, 2023: Neuropharmacology
https://read.qxmd.com/read/37688769/a-comprehensive-survival-and-prognosis-analysis-of-gpr55-expression-in-hepatocellular-carcinoma
#13
JOURNAL ARTICLE
Tianyu Wang, Kang Xia, Tao Qiu, Shangting Han, Zhongbao Chen, Xiaoxiong Ma, Long Zhang, Jilin Zou, Yalong Zhang, Bo Yu, Chenyang Kong, Jiayu Guo, Yiting Liu, Jiangqiao Zhou, Shusen Zheng
Hepatocellular carcinoma (HCC) is the most common subtype, accounting for about 90% of all primary liver cancers. The liver is rich in a large number of immune cells, thus forming a special immune microenvironment, which plays a key role in the occurrence and development of hepatocellular carcinoma. Nowadays, tumor immunotherapy has become one of the most promising cancer treatment methods. Immune checkpoint inhibitors (ICIs) combined with VEGF inhibitors are listed as first-line treatment options for advanced HCC...
September 8, 2023: Aging
https://read.qxmd.com/read/37628684/liver-involvement-in-patients-with-rare-mboat7-variants-and-intellectual-disability-a-case-report-and-literature-review
#14
Luisa Ronzoni, Matteo Mureddu, Francesco Malvestiti, Vittoria Moretti, Cristiana Bianco, Giulia Periti, Margherita Baldassarri, Francesca Ariani, Anna Carrer, Serena Pelusi, Alessandra Renieri, Daniele Prati, Luca Valenti
The membrane-bound O-acyltransferase domain-containing 7 (MBOAT7) protein is an acyltransferase catalyzing arachidonic acid incorporation into lysophosphatidylinositol. Patients with rare, biallelic loss-of-function variants of the MBOAT7 gene display intellectual disability with neurodevelopmental defects. The rs641738 inherited variant associated with reduced hepatic MBOAT7 expression has been linked to steatotic liver disease susceptibility. However, the impact of biallelic loss-of-function MBOAT7 variants on liver disease is not known...
August 16, 2023: Genes
https://read.qxmd.com/read/37509314/disturbed-plasma-lipidomic-profiles-in-females-with-diffuse-large-b-cell-lymphoma-a-pilot-study
#15
JOURNAL ARTICLE
Romana Masnikosa, David Pirić, Julia Maria Post, Zorica Cvetković, Snježana Petrović, Marija Paunović, Vesna Vučić, Laura Bindila
Lipidome dysregulation is a hallmark of cancer and inflammation. The global plasma lipidome and sub-lipidome of inflammatory pathways have not been reported in diffuse large B-cell lymphoma (DLBCL). In a pilot study of plasma lipid variation in female DLBCL patients and BMI-matched disease-free controls, we performed targeted lipidomics using LC-MRM to quantify lipid mediators of inflammation and immunity, and those known or hypothesised to be involved in cancer progression: sphingolipids, resolvin D1, arachidonic acid (AA)-derived oxylipins, such as hydroxyeicosatetraenoic acids (HETEs) and dihydroxyeicosatrienoic acids, along with their membrane structural precursors...
July 18, 2023: Cancers
https://read.qxmd.com/read/37500529/-analysis-of-soybean-phospholipids-based-on-liquid-chromatography-ion-trap-time-of-flight-mass-spectrometry
#16
JOURNAL ARTICLE
Yuehan Liu, Tingting Liu, Jingqi Niu, Siyu Wang, Xuesong Zhang, Shuang Song, Zhu Wang
OBJECTIVE: Using liquid chromatography-ion trap-time of flight-mass spectrometry to establish a soybean phospholipids(PL) analysis method, carry out comprehensive structural identification and quantitative analysis of soybean PL molecule species, and obtain soybean PL molecular composition and content data. METHODS: The PL profiles of 10 soybean varieties cultivated in northeast China were determined by a hydrophilic interaction liquid chromatography-ion trap-time of flight-mass spectrometry(HILIC-ESI-IT-TOF-MS) system...
May 2023: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://read.qxmd.com/read/37375157/quantitative-lipidome-analysis-of-boiled-chicken-egg-yolk-under-different-heating-intensities
#17
JOURNAL ARTICLE
Wei Luo, Jinghui Wang, Yan Chen, Qionglian Zhang, Jinqiu Wang, Fang Geng
The effects of the four heating intensities (hot-spring egg yolk, HEY; soft-boiled egg yolk, SEY; normal-boiled egg yolk, NEY; and over-boiled egg yolk, OEY) on lipidomes of boiled egg yolks were investigated. The results indicated that four heating intensities had no significant effect on the total abundance of lipids and lipid categories except for bile acids, lysophosphatidylinositol, and lysophosphatidylcholine. However, of all the 767 lipids quantified, the differential abundance of 190 lipids was screened among the egg yolk samples at four heating intensities...
June 7, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37372090/the-expression-of-the-endocannabinoid-receptors-cb2-and-gpr55-is-highly-increased-during-the-progression-of-alzheimer-s-disease-in-app-nl-g-f-knock-in-mice
#18
JOURNAL ARTICLE
Dina Medina-Vera, Hongjing Zhao, Erika Bereczki, Cristina Rosell-Valle, Makoto Shimozawa, Gefei Chen, Fernando Rodríguez de Fonseca, Per Nilsson, Simone Tambaro
BACKGROUND: The endocannabinoid system (ECS) and associated lipid transmitter-based signaling systems play an important role in modulating brain neuroinflammation. ECS is affected in neurodegenerative disorders, such as Alzheimer's disease (AD). Here we have evaluated the non-psychotropic endocannabinoid receptor type 2 (CB2) and lysophosphatidylinositol G-protein-coupled receptor 55 (GPR55) localization and expression during Aβ-pathology progression. METHODS: Hippocampal gene expression of CB2 and GPR55 was explored by qPCR analysis, and brain distribution was evaluated by immunofluorescence in the wild type (WT) and APP knock-in AppNL-G-F AD mouse model...
May 31, 2023: Biology
https://read.qxmd.com/read/37339697/metabolomic-signature-and-molecular-profile-of-normal-and-degenerated-human-intervertebral-disc-cells
#19
JOURNAL ARTICLE
Vera Francisco, Djedjiga Ait Eldjoudi, María González-Rodríguez, Clara Ruiz-Fernández, Alfonso Cordero-Barreal, Patrice Marques, Maria Jesus Sanz, José T Real, Francisca Lago, Jesus Pino, Yousof Farrag, Oreste Gualillo
BACKGROUND CONTEXT: Intervertebral disc degeneration (IVDD) is an incurable, specific treatment-orphan disease with an increasing burden worldwide. Although great efforts have been made to develop new regenerative therapies, their clinical success is limited. PURPOSE: Characterize the metabolomic and gene expression changes underpinning human disc degeneration. This study also aimed to disclose new molecular targets for developing and optimizing novel biological approaches for IVDD...
June 18, 2023: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/37307400/sphingolipid-and-phospholipid-levels-are-altered-in-human-brain-in-chorea-acanthocytosis
#20
JOURNAL ARTICLE
Gabriel Miltenberger-Miltenyi, Attila Jones, Amber M Tetlow, Vasco A Conceição, John F Crary, Ricky Michael Ditzel, Kurt Farrell, Renu Nandakumar, Brandon Barton, Barbara I Karp, Alana Kirby, Debra J Lett, Karin Mente, Susan Morgello, David K Simon, Ruth H Walker
BACKGROUND: Chorea-acanthocytosis (ChAc) is associated with mutations of VPS13A, which encodes for chorein, a protein implicated in lipid transport at intracellular membrane contact sites. OBJECTIVES: The goal of this study was to establish the lipidomic profile of patients with ChAc. METHODS: We analyzed 593 lipid species in the caudate nucleus (CN), putamen, and dorsolateral prefrontal cortex (DLPFC) from postmortem tissues of four patients with ChAc and six patients without ChAc...
August 2023: Movement Disorders: Official Journal of the Movement Disorder Society
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