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Jeong-Eun Park, Tae-Eun Kim, Kwang-Hee Shin
Green tea is consumed as a beverage worldwide and has beneficial effects, such as a lower risk of cardiovascular disease and cancer. A quantitative analysis of the beneficial components in plasma is important for understanding the potential health benefits of green tea. Four catechins—epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG), epigallocatechin (EGC), and epicatechin (EC)—which account for the majority of the components of green tea, were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
April 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Feng Li, Yongli Wang, Dapeng Li, Yilun Chen, Xuguang Qiao, Rania Fardous, Ashton Lewandowski, Jinbao Liu, Tak-Hang Chan, Q Ping Dou
Increasing evidence has expanded the role of green tea from a traditional beverage to a source of pharmacologically active molecules with diverse health benefits. However, conclusive clinical results are needed to better elucidate the cancer-preventive and therapeutic effects of green tea polyphenols (GTPs). Areas covered: The authors describe GTPs' chemical compositions and metabolic biotransformations, and their recent developments in drug discovery, focusing on their cancer chemopreventive and therapeutic effects...
April 24, 2018: Expert Opinion on Drug Discovery
C-G Zhou, L-M Hui, J-M Luo
OBJECTIVE: Epigallocatechin gallate (EGCG), the major chemical constituent of green tea, exhibits remarkable anti-tumor effect properties. In the present work, we aim to explore the effect and underlying mechanism of EGCG on multiple myeloma (MM) cells. MATERIALS AND METHODS: The effects of EGCG on MM cells proliferation and apoptosis were determined by CCK-8 assay and flow cytometry assay. The siRNAs were used to inhibit endogenous expression of EZH2. Enforced expression of EZH2 in U266 cells was accomplished by transfecting EZH2 plasmid...
April 2018: European Review for Medical and Pharmacological Sciences
Sangeeta Rangi, Sunil Kumar Dhatwalia, Priti Bhardwaj, Manoj Kumar, D K Dhawan
The present study was conducted to unravel the comparative efficacy of White Tea (WT) and Epigallocatechin gallate (EGCG) in affording protection against benzo (a) pyrene (BaP) induced hepatotoxicity. The animals were randomly divided into six groups viz., normal control (NC), BaP, EGCG, WT, WT + BaP and EGCG + BaP treated. 50 mg/kg of BaP was given orally twice a week for 4 weeks. WT extract (1%) and EGCG (1% WT equivalent) were given on alternate days for 12 weeks (4 weeks prior, during and after BaP treatment)...
April 20, 2018: Food and Chemical Toxicology
Jun Shi, Min Zhang, Libin Zhang, Huipin Deng
Our previous study showed that the tea extract, epigallocatechin-3-gallate (EGCG), protects against microcystin-LR (MC-LR) -mediated apoptosis of human umbilical vein endothelial cells (HUVECs); however, the mechanism underlying MC-LR-induced HUVEC apoptosis remains incompletely understood. In this study, we investigated whether the nuclear factor erythroid-like 2 (NRF2)/heme oxygenase-1 (HO-1) pathway, which regulates antioxidant transcriptional regulation of oxidative stress and apoptosis, is involved in this process...
April 18, 2018: Environmental Pollution
Weimei Shi, Linfu Li, Yechun Ding, Kai Yang, Zhixi Chen, Xiaona Fan, Shan Jiang, Yingjie Guan, Zhiping Liu, Daohua Xu, Longhuo Wu
Epigallocatechin gallate (EGCG), one of polyphenols isolated from green tea, exhibits biology-benefiting effects with minimum severe adverse. EGCG is known to be a mitochondrion-targeting medicinal agent, regulating mitochondrial metabolism, including mitochondrial biogenesis, mitochondrial bioenergetics, and mitochondria-mediated cell cycle and apoptosis. EGCG might exhibit either antioxidative activity to prevent against oxidative stress or pro-oxidative activity to counteract cancer cells, which depends on the cellular stress situations, cell types and the concentration of EGCG...
April 19, 2018: Future Medicinal Chemistry
Xiao Li, Guang-Jin Liu, Wei Zhang, Yv-Long Zhou, Tie-Jun Ling, Xiao-Chun Wan, Guan-Hu Bao
Two novel flavoalkaloids, (-)-6-(5'''S)-N-ethyl-2-pyrrolidinone-epigallocatechin -O-gallate (ester-type catechins pyrrolidinone A, etc-pyrrolidinone A, 1), (-)-6-(5'''R)-N-ethyl-2-pyrrolidinone-epigallocatechin-O-gallate (etc-pyrrolidinone B,2) and new naturally occurring flavoalkaloids (-)-8-N-ethyl-2-pyrrolidinone-epigallocatechin-O-gallate (etc-pyrrolidinone C,3a and etc- pyrrolidinone D,3b), were isolated from white tea (Camellia sinensis). Their structures were identified by extensive NMR spectra...
April 18, 2018: Journal of Agricultural and Food Chemistry
Matthew J Vergne, Ankit Patras, Manreet S Bhullar, Lincoln M Shade, Michael Sasges, Kanyasiri Rakariyatham, Che Pan, Hang Xiao
Short-wavelength ultraviolet (UV-C) irradiation is a nonthermal processing technique that is a possible alternative to the heat-pasteurization of tea beverages. This study investigated the effect of UV-C irradiation on the polyphenolic and total phenolic contents of a green tea beverage and analyzed cytotoxicity of irradiated green tea using a novel continuous flow-through UV system. UV-C fluence levels ranging from 0 to 240 mJ/cm2 were delivered to green tea, and polyphenols were chemically profiled. Continuous-flow UV-C irradiation of the green tea beverage at a fluence of 68 mJ/cm2  induced a minor reduction in the concentration of the most abundant catechin in green tea, (-)-epigallocatechin gallate (EGCG), from 145 to 131...
April 18, 2018: Journal of Food Science
Hui Zhang, Xiumei Jiang, Gaojuan Cao, Xiaowei Zhang, Timothy R Croley, Xiaochun Wu, Jun-Jie Yin
Noble metal nanoparticles (NPs) have been widely used in many consumer products. Their effects on the antioxidant activity of commercial dietary supplements have not been well evaluated. In this study, we examined the effects of gold (Au NPs), silver (Ag NPs), platinum (Pt NPs), and palladium (Pd NPs) on the hydroxyl radical (·OH) scavenging ability of three dietary supplements vitamin C (L-ascorbic acid, AA), (-)-epigallocatechin gallate (EGCG), and gallic acid (GA). By electron spin resonance (ESR) spin-trapping measurement, the results show that these noble metal NPs can inhibit the hydroxyl radical scavenging ability of these dietary supplements...
April 3, 2018: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
Daniel A Martinez-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Epigallocatechin-3-gallate (EGCG) is a polyhydroxyphenol constituent of green tea (e.g., Camellia sinensis) with known antioxidant properties. Due to these properties, others have proposed it as a potential therapeutic agent for the treatment of Parkinson's disease (PD). Previously, we demonstrated that EGCG prolonged the lifespan and locomotor activity in wild-type Canton-S flies exposed to the neurotoxicant paraquat (PQ), suggesting neuroprotective properties. Both gene mutations and environmental neurotoxicants (e...
April 17, 2018: Neurotoxicity Research
Rashik Ahmed, Giuseppe Melacini
The self-association of the amyloid beta (Aβ) peptide into toxic oligomers is implicated in the early events leading to Alzheimer's disease (AD). Blocking the formation of Aβ oligomers and their interactions with the extracellular and cellular environment through small molecules and biopharmaceuticals is therefore a promising preventive strategy for AD. However, given the heterogeneity and transient nature of the Aβ oligomeric species, detailed structural and kinetic characterizations of such oligomers and oligomer:inhibitor complexes have proven to be challenging...
April 16, 2018: Chemical Communications: Chem Comm
Zhi Wang, Baozhen Sun, Fei Zhu
Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea and exhibits potential antibacterial and anticancer activities. In this study, EGCG was used in pathogen-challenge experiments in shrimp to discover its effect on the innate immune system of an invertebrate. Kuruma shrimp Marsupeneaus japonicus was used as an experimental model and challenged with white spot syndrome virus (WSSV) and the Gram-negative bacterium Vibrio alginolyticus. Pathogen-challenge experiments showed that EGCG pretreatment significantly delayed and reduced mortality upon WSSV and V...
April 12, 2018: Fish & Shellfish Immunology
Rajeswari Kalaiselvam, Arathi Ganesh, Mathan Rajan, Deivanayagam Kandaswamy
Aim: This study aims to evaluate the effect of two bioflavonoids (epigallocatechin-3-gallate [EGCG] and catechin) and a protein inhibitor (chlorhexidine [CHX]) on the immediate and delayed microtensile bond strength of self-etch and total-etch adhesive systems to sound dentin. Materials and Methods: The occlusal surfaces of 96 mandibular human third molar teeth specimens were ground after removal of the excess tissues, to expose the middle dentin. The dentin specimens were randomly allocated into four groups, each consisting of 24 teeth (n = 24) according to the application of the enzyme inhibitor...
March 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Masome Ghasemi-Pirbaluti, Batoul Pourgheysari, Hedayatollah Shirzad, Zahra Sourani, Pezhman Beshkar
Acute lymphoblastic leukemia is the most prevalent cancer in children. Novel components to help struggle aggressive malignancies and overcome some side effects of conventional treatments could be a promising strategy. Epigallocatechingallate (EGCG), have attracted the attention of scientists for prevention or treatment of some cancers. Jurkat cells were incubated with the different concentrations of EGCG (30-100 µm) for 24, 48, and 72 h and cell viability was investigated using MTS test. Apoptosis and the level of caspase 3 alterations were evaluated using flowcytometry and expression of Fas by Real Time PCR...
April 2018: Indian Journal of Hematology & Blood Transfusion
Keyan Chen, Wei Chen, Shi Li Liu, Tian Shi Wu, Kai Feng Yu, Jing Qi, Yijun Wang, Hui Yao, Xiao Yang Huang, Ying Han, Ping Hou
The present study aimed to assess the protective effect of epigallocatechingallate (EGCG) against myocardial injury in a mouse model of heart failure and to determine the mechanism underlying regulation of the transforming growth factor‑β1/mothers against decapentaplegic homolog 3 (TGF‑β1/Smad3) signaling pathway. Mouse models of heart failure were established. Alterations in ejection fraction, left ventricular internal diastolic diameter (LVIDd) and left ventricular internal systolic diameter (LVIDs) were measured by echocardiography...
March 29, 2018: Molecular Medicine Reports
Xuanyi Du, Jinfeng Yu, Xiaohan Sun, Shaochuan Qu, Haitao Zhang, Mengying Hu, Shufen Yang, Ping Zhou
The aim of the present study was to investigate the antioxidant response mechanism of epigallocatechin‑3‑gallate (EGCG) in H2O2‑induced mouse renal tubular epithelial cells (MRTECs). The cultured MRTECs were divided into normal, H2O2 (control) and EGCG treatment groups. The MTT assay was used to assess cell viability, and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), immunocytochemical and western blot analyses were performed to detect the expression of nuclear factor erythroid 2‑related factor 2 (Nrf2) and γ‑glutamyl cysteine synthetase (γ‑GCS)...
March 28, 2018: Molecular Medicine Reports
K R D Sagara N S Gurusinghe, Aanchal Mishra, Seema Mishra
Glucose-regulated protein 78 (GRP78), is overexpressed in glioblastoma, other tumors and during viral and bacterial infections, and so, it is postulated to be a key drug target. EGCG, an ATP-competitive natural inhibitor, inhibits GRP78 effect in glioblastoma. Structural basis of its action on GRP78 nucleotide-binding domain and selectivity has been investigated. We were interested in exploring the large-scale conformational movements travelling to substrate-binding domain via linker region. Conformational effects of EGCG inhibitor as well as ATP on full length GRP78 protein were studied using powerful MD simulations...
April 3, 2018: Scientific Reports
Rohit Kumar Singh, Sourav Mishra, Satyapriya Jena, Bijayananda Panigrahi, Bhaskar Das, Rasu Jayabalan, Pankaj Kumar Parhi, Dindyal Mandal
Polyphenol functionalized silver nanoparticles (AgNPs) have been developed and demonstrated as colorimetric sensors for the selective detection of gadolinium. The newly obtained AgNP-Gd3+ conjugates exhibit high aqueous dispersibility and excitation dependent fluorescence emission. The conjugates offer multicolor bioimaging potential owing to their excellent luminescence properties.
April 3, 2018: Chemical Communications: Chem Comm
Masafumi Hidaka, Keita Kosaka, Saori Tsushima, Chiyoko Uchida, Katsuhiko Takahashi, Noriko Takahashi, Masayoshi Tsubuki, Yukihiko Hara, Takafumi Uchida
We searched for inhibitors against prolyl isomerase Pin1 in order to develop functional foods to prevent and cure various Pin1 related diseases such as cancer, diabetes, cardiovascular disease, Alzheimers's disease, and so on. We created a polyphenol library consisting of ingredients in healthy foods and beverages, since polyphenols like epigallocatechin gallate (EGCG) in green tea and 974B in brown algae had been identified as its Pin1 inhibitors. Several polyphenols such as EGCG derivatives, caffeic acid derivatives and tannic acid inhibited Pin1 activity...
March 30, 2018: Biochemical and Biophysical Research Communications
Kensuke Nakajima, Shigeru Oiso, Hiroko Kariyazono
Ghrelin is an orexigenic peptide hormone produced in the stomach. The major active form is octanoylated ghrelin, which is modified with an n-octanoic acid at the serine-3 residue. Inhibition of octanoylated ghrelin production is useful for the prevention and improvement of obesity. We previously developed a cell-based assay system employing a ghrelin-expressing cell line, AGS-GHRL8, and found various compounds that decreased octanoylated ghrelin levels using this system. (-)-Epigallocatechin-3-O-gallate (EGCG) is a bioactive catechin in green tea and reportedly has an anti-obesity effect; however, it remains unclear whether EGCG inhibits octanoylated ghrelin production...
2018: Biological & Pharmaceutical Bulletin
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