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https://www.readbyqxmd.com/read/29230104/metformin-sensitizes-non-small-cell-lung-cancer-cells-to-an-epigallocatechin-3-gallate-egcg-treatment-by-suppressing-the-nrf2-ho-1-signaling-pathway
#1
Chenxiao Yu, Yang Jiao, Jiao Xue, Qi Zhang, Hongying Yang, Ligang Xing, Guangxia Chen, Jinchang Wu, Shuyu Zhang, Wei Zhu, Jianping Cao
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. (-)-Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, is widely studied as a cancer chemopreventive agent with potential anti-cancer effects. The NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway is considered to mediate cellular resistance to EGCG. Metformin, a classical antidiabetic drug, has been shown to prevent cancer progression. Researchers have not reported whether metformin potentiates the anti-cancer efficacy of EGCG...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29228755/long-term-supplementation-of-decaffeinated-green-tea-extract-does-not-modify-body-weight-or-abdominal-obesity-in-a-randomized-trial-of-men-at-high-risk-for-prostate-cancer
#2
Nagi B Kumar, Roshni Patel, Julio Pow-Sang, Philippe E Spiess, Raoul Salup, Christopher R Williams, Michael J Schell
Background: Evidence continues to demonstrate the role of obesity in prostate carcinogenesis and prognosis, underscoring the need to identify and continue to evaluate the effective interventions to reduce obesity in populations at high risk. The aim of the study was to determine the effect of daily consumption of decaffeinated green tea catechins (GTC) formulation (Polyphenon E® (PolyE)) for 1 year on biomarkers of obesity in men who are at high risk for prostate cancer. Materials and Methods: A randomized, double-blinded trial was conducted targeting 97 men diagnosed with HGPIN or ASAP...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227650/molecular-evidence-for-catechin-synthesis-and-accumulation-in-tea-buds-camellia-sinensis
#3
Xinzhen Wang, Lina Guo, Liping Gao, Xingxing Shi, Xuecheng Zhao, Xiubing Ma, Tao Xia, Yunsheng Wang
Early spring buds of the Camellia sinensis variety Shuchazao were separated into two parts, including the shoot tip (ST) and non-expanded young leaves (YL). Then, the synthesis and accumulation of catechins in the two parts were assessed by HPLC, DMACA staining, qRT-PCR and in situ hybridization. HPLC showed that EGCG and ECG amounts in YL were increased significantly by 74.0% and 71.8%, respectively. The results of DMACA staining indicated that catechins in buds accumulated mainly in mesophyll cells and bud shaft of YL...
December 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29226083/effects-of-o-methylated-epigallocatechin-gallate-egcg-on-lps-induced-osteoclastogenesis-bone-resorption-and-alveolar-bone-loss-in-mice
#4
Tsukasa Tominari, Ryota Ichimaru, Shosei Yoshinouchi, Chiho Matsumoto, Kenta Watanabe, Michiko Hirata, Florian M W Grundler, Masaki Inada, Chisato Miyaura
(-)-Epigallocatechin-3-O-gallate (EGCG), present in green tea, exhibits antioxidant and antiallergy effects. EGCG3″Me, a 3-O-methylated derivative of EGCG, has been reported to show similar biological functions; the inhibitory activity of EGCG3″Me in a mouse allergy model was more potent than that of EGCG, probably due to the efficiency of absorption from the intestine. However, the functional potency of these EGCGs is controversial in each disease model. We previously observed that EGCG suppressed inflammatory bone resorption and prevented alveolar bone loss in a mouse model of periodontosis...
December 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29225315/comparison-of-the-effects-of-three-tea-cultivars-camellia-sinensis-l-on-nitric-oxide-production-and-aortic-soluble-guanylate-cyclase-expression-in-high-salt-diet-fed-spontaneously-hypertensive-rats
#5
Sachiko Nomura, Manami Monobe, Kaori Ema, Mari Maeda-Yamamoto, Atsushi Nesumi
Studies have suggested that the consumption of green tea reduces the risk of cardiovascular diseases. Although epigallocatechin gallate (EGCG) is the best studied active substance characteristic of green tea, previous results on EGCG do not appear sufficient to explain completely the mechanism of cardiovascular protection by green tea. Therefore, we investigated the effect of three different tea cultivars, "Yabukita," "Sofu," and "Sunrouge," which have characteristic flavonoid compositions, on the nitric oxide (NO) production and the related protein expression in the aorta of spontaneously hypertensive rats (SHRs) fed a high-salt diet...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29214243/intracellular-investigation-on-the-differential-effects-of-4-polyphenols-on-mcf-7-breast-cancer-cells-by-raman-imaging
#6
A Mignolet, B R Wood, E Goormaghtigh
The past decades have seen significant interest in the study of polyphenolic compounds as potential therapeutic agents in medicine because they display a vast array of cellular effects beneficial to treat or manage a plethora of chronic diseases including inflammatory diseases, cardiovascular abnormalities and several types of cancer. These compounds act at different stages of carcinogenesis but deciphering their mode of action is a complex task. Live MCF-7 breast cancer cells were investigated using Raman imaging to evaluate the perturbations induced after incubating cells with four different polyphenols: EGCG, gallic acid, resveratrol and tannic acid...
December 7, 2017: Analyst
https://www.readbyqxmd.com/read/29209211/diabetes-mellitus-and-alzheimer-s-disease-the-protection-of-epigallocatechin-3-gallate-in-streptozotocin-injection-induced-models
#7
REVIEW
Jin-Jing Jia, Xian-Si Zeng, Xin-Qiang Song, Peng-Peng Zhang, Lei Chen
Diabetes mellitus is considered as a risk factor of Alzheimer's disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29207926/nature-derived-epigallocatechin-gallate-duck-s-feet-collagen-hydroxyapatite-composite-sponges-for-enhanced-bone-tissue-regeneration
#8
Yeon Ji Kook, Jingwen Tian, Yoo Shin Jeon, Min Jung Choi, Jeong Eun Song, Chan Hum Park, Rui L Reis, Gilson Khang
Scaffolds mimicking structural and chemical characteristics of the native bone tissues are critical for bone tissue engineering. Herein, we have developed and characterized epigallocatechin gallate/duck's feet collagen/hydroxyapatite (EGCG/DC/HAp) composite sponges that enhanced the bone tissue regeneration. The three-dimensional composite sponges were synthesized by loading various amounts (i.e. 1 μM, 5 μM and 10 μM) of EGCG to duck feet derived collagen followed by freeze-drying and then coating with hydroxyapatite...
December 6, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29207033/epigallocatechin-3-gallate-inhibits-inflammation-and-epithelial%C3%A2-mesenchymal-transition-through-the-pi3k-akt-pathway-via-upregulation-of-pten-in-asthma
#9
Nan Yang, Han Zhang, Xuxu Cai, Yunxiao Shang
Asthma is a chronic disease associated with hyperresponsiveness, obstruction and remodeling of the airways. Epithelial-mesenchymal transition (EMT) has an important role in these alterations and may account for the accumulation of subepithelial mesenchymal cells, thus contributing to airway hyperresponsiveness and remodeling. Epigallo-catechin‑3‑gallate (EGCG), which is a type of polyphenol, is the most potent ingredient in green tea, and exhibits antibacterial, antiviral, antioxidative, anticancer and chemopreventive activities...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29206487/role-of-catechins-on-et-1-induced-stimulation-of-pld-and-nadph-oxidase-activities-in-pulmonary-smooth-muscle-cells-determination-of-the-probable-mechanism-by-molecular-docking-studies
#10
Sajal Chakraborti, Jaganmay Sarkar, Rajabrata Bhuyan, Tapati Chakraborti
Treatment of human pulmonary artery smooth muscle cells with ET-1 stimulated PLD and NADPH oxidase activities, which were inhibited upon pretreatment with bosentan (ET-1 receptor antagonist), FIPI (PLD inhibitor), apocynin (NADPH oxidase inhibitor) and EGCG & ECG (catechins having galloyl group), but not EGC & EC (catechins devoid of galloyl group). Herein, we determined the probable mechanism by which the galloyl group containing catechins inhibit ET-1 induced stimulation of PLD activity by molecular docking analyses based on our biochemical studies...
December 5, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29206141/-epigallocatechin-3-gallate-inhibits-the-chaperone-activity-of-plasmodium-falciparum-hsp70-chaperones-and-abrogates-their-association-with-functional-partners
#11
Tawanda Zininga, Lebogang Ramatsui, Pertunia Bveledzani Makhado, Stanley Makumire, Ikechukwu Achilinou, Heinrich Hoppe, Heini Dirr, Addmore Shonhai
Heat shock proteins (Hsps), amongst them, Hsp70 and Hsp90 families, serve mainly as facilitators of protein folding (molecular chaperones) of the cell. The Hsp70 family of proteins represents one of the most important molecular chaperones in the cell. Plasmodium falciparum, the main agent of malaria, expresses six Hsp70 isoforms. Two (PfHsp70-1 and PfHsp70-z) of these localize to the parasite cytosol. PHsp70-1 is known to occur in a functional complex with another chaperone, PfHsp90 via a co-chaperone, P. falciparum Hsp70-Hsp90 organising protein (PfHop)...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29200710/identification-of-hepatoprotective-constituents-in-limonium-tetragonum-and-development-of-simultaneous-analysis-method-using-high-performance-liquid-chromatography
#12
Jae Sun Lee, Yun Na Kim, Na-Hyun Kim, Jeong-Doo Heo, Min Hye Yang, Jung-Rae Rho, Eun Ju Jeong
Background: Limonium tetragonum, a naturally salt-tolerant halophyte, has been studied recently and is of much interest to researchers due to its potent antioxidant and hepatoprotective activities. Objective: In the present study, we attempted to elucidate bioactive compounds from ethyl acetate (EtOAc) soluble fraction of L. tetragonum extract. Furthermore, the simultaneous analysis method of bioactive EtOAc fraction of L. tetragonum has been developed using high-performance liquid chromatography (HPLC)...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29197967/effects-of-nutraceuticals-on-anaplastic-thyroid-cancer-cells
#13
Lorenzo Allegri, Francesca Rosignolo, Catia Mio, Sebastiano Filetti, Federica Baldan, Giuseppe Damante
PURPOSE: The anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a high mortality rate. Since nutraceuticals may exert beneficial effects on tumor biology, here, effects of four of these compounds [resveratrol, genistein, curcumin and epigallocatechin-3-gallate (EGCG)] on ATC cell lines were investigated. METHODS: Two ATC-derived cell lines were used: SW1736 and 8505C. Cell viability and in vitro aggressiveness was tested by MTT and soft agar assays...
December 2, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29196011/investigation-of-epigallocatechin-3-o-caffeoate-and-epigallocatechin-3-o-p-coumaroate-in-tea-leaves-by-lc-ms-ms-analysis
#14
Masahiro Umehara, Koji Yanae, Hiroko Maruki-Uchida, Masahiko Sai
(-)-Epigallocatechin-3-O-gallate (EGCG), the major catechin present in green tea, exhibits potent antioxidant activity. We thereby investigated the presence of unknown components bearing the (-)-epigallocatechin (EGC) moiety in fresh tea leaf samples. Initially, liquid chromatography tandem mass spectrometry (LC-MS/MS) was employed to examine fresh tea leaves of the Yabukita, the most popular tea cultivar in Japan, which suggested the presence of the EGC phenylpropanoid derivatives, (-)-epigallocatechin-3-O-p-coumaroate (EGCpCA) and (-)-epigallocatechin-3-O-caffeoate (EGCCA)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29194370/alternative-oral-agents-in-prophylaxis-and-therapy-of-uterine-fibroids-an-up-to-date-review
#15
REVIEW
Michał Ciebiera, Krzysztof Łukaszuk, Błażej Męczekalski, Magdalena Ciebiera, Cezary Wojtyła, Aneta Słabuszewska-Jóźwiak, Grzegorz Jakiel
Uterine fibroids (UFs) are the most common tumors of the female genital tract. The effect of UFs on the quality of life and the overall cost of treatment are significant issues worldwide. Tumor size and location are the two specific factors which influence the occurrence of symptoms, the need for, and method of, treatment (some tumors require surgery while some can be treated with selected drugs). Primary prevention and treatment of early UF disease are worthy goals that might have a great impact on health care systems...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29193405/epigallocatechin-3-gallate-enhances-differentiation-of-acute-promyelocytic-leukemia-cells-via-inhibition-of-pml-rar%C3%AE-and-hdac1
#16
Maliheh Moradzadeh, Abazar Roustazadeh, Alijan Tabarraei, Saiedeh Erfanian, Amirhossein Sahebkar
The use of all-trans retinoic acid (ATRA) has dramatically improved the treatment and survival rate of patients with acute promyelocytic leukemia (APL). However, toxicity and resistance to this drug are major problems in the treatment of APL with ATRA. Earlier studies have suggested that the green tea polyphenol epigallocatechin gallate (EGCG) induces cell death in hematopoietic neoplasms without adversely affecting normal cells. In the present study, the potential therapeutic effect of EGCG in APL and the underlying molecular mechanisms were investigated...
November 29, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29186186/application-of-non-invasive-low-strength-pulsed-electric-field-to-egcg-treatment-synergistically-enhanced-the-inhibition-effect-on-panc-1-cells
#17
Chih-Hsiung Hsieh, Chueh-Hsuan Lu, Wei-Ting Chen, Bo-Lun Ma, Chih-Yu Chao
Traditional therapies for pancreatic cancer are usually expensive and likely to cause side effects, and most patients have the risk of recurrence and suffering pain. Here, we investigated combination treatment of epigallocatechin-3-gallate (EGCG) and non-invasive low strength pulsed electric field (PEF) on the human pancreatic cell line PANC-1. Cells were cultured in various concentrations of EGCG and exposed to trains of PEF. The results showed that the low strength PEF alone or single treatment with low concentration of EGCG did not obviously affect the cell proliferation and migration in PANC-1...
2017: PloS One
https://www.readbyqxmd.com/read/29181486/epigallocatechin-3-gallate-as-an-inhibitor-of-tau-phosphorylation-and-aggregation-a-molecular-and-structural-insight
#18
M Guéroux, C Fleau, M Slozeck, M Laguerre, I Pianet
Polyphenols such as Epigallocatechin-3 gallate (EGCG) are currently bearer of hope to prevent or at least to slow down the deleterious effect of Tauopathies such as Alzheimer disease. One of the main effects of these neurodegenerative pathologies is the hyperphosphorylation and consequent aggregation of the Tau protein that leads to the irremediable neuronal cells death. In the present paper, we show how EGCG can play a crucial role to prevent Tau aggregation: (i) in binding Tau in its phosphorylation region with an affinity of the same order of magnitude than kinases (0...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29180927/comparative-efficacy-of-epigallocatechin-3-gallate-against-h2o2-induced-ros-in-cervical-cancer-biopsies-and-hela-cell-lines
#19
Sohail Hussain
Aim of the study: Antioxidants play an important role in maintaining physiological homeostasis. Recent literature emphasises the potential therapeutic effects of natural antioxidants that play anti-inflammatory and antioxidant effects applicable in preventing oxidative stress-induced injury, which characterises their pathogenesis. The goal of this study was to evaluate the protective role of EGCG on the HeLa cell line and cancerous cells. Material and methods: The HeLa cell line and cervical cancer biopsies (CCB) were treated with varying doses of antioxidants to determine their effects...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29175576/potential-role-of-the-mitochondria-as-a-target-for-the-hepatotoxic-effects-of-epigallocatechin-3-gallate-in-mice
#20
Karma D James, Mary J Kennett, Joshua D Lambert
Green tea and (-)-epigallocatechin-3-gallate (EGCG) have been studied for their obesity-related health effects. Many green tea extract (GTE)-based dietary supplements are commercially-available. Although green tea beverage has a long history of safe use, a growing number of case-reports have linked GTE-based supplements to incidents of hepatotoxicity. Animal studies support the hepatotoxic potential of GTE and EGCG, but the mechanisms remain unclear. Here, we examined the hepatotoxic effects of EGCG in C57BL/6J mice and evaluated changes in hepatic antioxidant response and mitochondria structure and function...
November 22, 2017: Food and Chemical Toxicology
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