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https://www.readbyqxmd.com/read/29451216/does-combined-therapy-of-curcumin-and-epigallocatechin-gallate-have-a-synergistic-neuroprotective-effect-against-spinal-cord-injury
#1
Jiri Ruzicka, Lucia Machova Urdzikova, Barbora Svobodova, Anubhav G Amin, Kristyna Karova, Jana Dubisova, Kristyna Zaviskova, Sarka Kubinova, Meic Schmidt, Meena Jhanwar-Uniyal, Pavla Jendelova
Systematic inflammatory response after spinal cord injury (SCI) is one of the factors leading to lesion development and a profound degree of functional loss. Anti-inflammatory compounds, such as curcumin and epigallocatechin gallate (EGCG) are known for their neuroprotective effects. In this study, we investigated the effect of combined therapy of curcumin and EGCG in a rat model of acute SCI induced by balloon compression. Immediately after SCI, rats received curcumin, EGCG, curcumin + EGCG or saline [daily intraperitoneal doses (curcumin, 6 mg/kg; EGCG 17 mg/kg)] and weekly intramuscular doses (curcumin, 60 mg/kg; EGCG 17 mg/kg)] for 28 days...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29449065/effects-of-fluoride-and-epigallocatechin-gallate-on-soft-drink-induced-dental-erosion-of-enamel-and-root-dentin
#2
Yin-Lin Wang, Hao-Hueng Chang, Yu-Chih Chiang, Yu-Chen Lu, Chun-Pin Lin
BACKGROUND/PURPOSE: Fluoride and epigallocatechin gallate (EGCG) have been proven to prevent dental caries. The purpose of this study was to evaluate the effects of fluoride and EGCG on soft-drink-induced dental erosion in vitro. METHODS: Forty enamel and dentin specimens were prepared from extracted human teeth. The specimens were divided into 4 groups and treated separately with distilled water (as control), 0.5 M sodium fluoride (NF), 400 μM EGCG (EG), and a solution containing 0...
February 12, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29447966/molecular-insights-on-the-interaction-and-preventive-potential-of-epigallocatechin-3-gallate-in-celiac-disease
#3
Ricardo Dias, Natércia F Brás, Iva Fernandes, Maria Pérez-Gregório, Nuno Mateus, Victor Freitas
Celiac Disease (CD) is now recognized as a worldwide epidemic. Although a gluten free diet usually induces clinical improvements within days or weeks, adhering to this routine is still troublesome. Therefore, new solutions are needed for quality-of-life improvement of CD patients. The present work intends to bring molecular and thermodynamic insights on the ability of green tea epigalhocatechin-3-gallate (EGCG) to interact and modulate the bioavailability of a major CD immunodominant peptide (32-mer). Characterization of peptide binding was assessed by means of both 1D and 2D 1 H NMR experiments, ITC and Molecular Dynamics simulations...
February 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29446867/epigallocatechin-gallate-reduces-amyloid-%C3%AE-induced-neurotoxicity-via-inhibiting-endoplasmic-reticulum-stress-mediated-apoptosis
#4
Ke Du, Mingyan Liu, Xin Zhong, Weifan Yao, Qinghuan Xiao, Quan Wen, Bo Yang, Minjie Wei
SCOPE: We investigated the role of endoplasmic reticulum (ER) stress in the protective effects of EGCG against the neuronal apoptosis in Aβ 1-42 -induced SH-SY5Y cells and APP/PS1 transgenic mice. METHODS AND RESULTS: Cell viability (CCK8 assay), flow cytometry, Hoechst 33258 staining, immunohistochemistry, Transmission Electron Microscopy (TEM), western blotting were used. EGCG prevented Aβ1-42-induced toxicity in SH-SY5Y cells, increased cell viability and decreased apoptosis in a dose-dependent manner...
February 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29446047/epigallocatechin-gallate-suppresses-hepatic-cholesterol-synthesis-by-targeting-srebp-2-through-sirt1-foxo1-signaling-pathway
#5
Yongnan Li, Shuodong Wu
This study aims to explore the effect of epigallocatechin gallate (EGCG) on blood lipids, liver lipids, and cholesterol synthesis in hyperlipidemic rats. SREBP-2 transgenic rats were used to investigate the transcriptional level of SREBP-2 regulated by SIRT-1/FOXO1 and the molecular mechanism of rate-limiting enzyme HMGCR that affects cholesterol synthesis. Rat models of hyperlipidemia were established and administered EGCG. Cholesterol synthesis was observed. Enzyme linked immunosorbent assay was used to determine serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), free fatty acid (FFA), superoxide dismutase (SOD), malondialdehyde (MDA), and T-AOC contents...
February 14, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29436217/a-stealth-and-fully-laden-drug-carrier-self-assembled-nanogel-encapsulated-with-epigallocatechin-gallate-and-sirna-for-drug-resistant-breast-cancer-therapy
#6
Jie Ding, Tingxizi Liang, Qianhao Min, Li-Ping Jiang, Jun-Jie Zhu
For co-delivery of therapeutic genes and chemical agents in combined therapy, the ideal drug delivery system (DDS) entails high-capacity and low-body toxicity carriers, allowing adequate drug dose for tumor region while yielding low residue in normal tissue. To augment the gene/drug load capacity and circumvent the potential toxicity brought by traditional inorganic and polymeric nanocarriers, a "stealth" carrier was herein designed in a simple self-assembly of (-)-epigallocatechin-3-O-gallate (EGCG) and small interfering RNA (siRNA) by recruiting protamine as biodegradable medium for the treatment of drug-resistant triple-negative breast cancer (TNBC)...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29436058/effects-of-a-standard-american-diet-and-an-anti-inflammatory-diet-in-male-and-female-mice
#7
S K Totsch, R Y Meir, T L Quinn, S A Lopez, B A Gower, R E Sorge
SIGNIFICANCE: Obesity may increase susceptibility to chronic pain often due to poor diet. Diet has potential to be used as treatment for pain. The current study investigates the use of a novel translatable diet to act as a preventative (i.e., prior to surgery) or an intervention (i.e., following an injury). BACKGROUND: Obesity and chronic pain are prevalent concerns. Pain is frequently experienced in weight bearing joints, but is common in other areas of the body as well, suggesting other factors...
February 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29434699/neuroprotective-effect-of-epigallocatechin-3-gallate-on-autoimmune-thyroiditis-in-a-rat-model-by-an-anti-inflammation-effect-anti-apoptosis-and-inhibition-of-trail-signaling-pathway
#8
Junfeng Li
(-)-Epigallocatechin-3-gallate (EGCG) is a polyphenol monomer compound extracted and separated from green tea, and is a key catechin in green tea. Recent research has identified that EGCG is equipped with important biological activities, including antitumor, antioxidant, anti-inflammation, blood fat reduction and radiation protection abilities. In the current study, it was investigated whether EGCG exerts a neuroprotective effect on AIT and examined the possible underlying mechanism. The present study sought to establish an experimental autoimmune thyroiditis (AIT) rat model and to investigate the neuroprotective effect of EGCG in this model...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29429153/cancer-prevention-with-green-tea-and-its-principal-constituent-egcg-from-early-investigations-to-current-focus-on-human-cancer-stem-cells
#9
Hirota Fujiki, Tatsuro Watanabe, Eisaburo Sueoka, Anchalee Rawangkan, Masami Suganuma
Cancer preventive activities of green tea and its main constituent, (-)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. Since 1983, we have studied the cancer chemopreventive effects of EGCG as well as green tea extract and underlying molecular mechanisms. The first part of this review summarizes groundbreaking topics with EGCG and green tea extract: 1) Delayed cancer onset as revealed by a 10-year prospective cohort study, 2) Prevention of colorectal adenoma recurrence by a double-blind randomized clinical phase II trial, 3) Inhibition of metastasis of B16 melanoma cells to the lungs of mice, 4) Increase in the average value of Young's moduli, i...
January 31, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29429035/inhibitory-effect-of-the-green-tea-molecule-egcg-against-dengue-virus-infection
#10
Muhareva Raekiansyah, Corazon C Buerano, Mark Anthony D Luz, Kouichi Morita
Dengue virus (DENV) infection is a major public health problem worldwide; however, specific antiviral drugs against it are not available. Hence, identifying effective antiviral agents for the prevention of DENV infection is important. In this study, we showed that the reportedly highly biologically active green-tea component epigallocatechin gallate (EGCG) inhibited dengue virus infection regardless of infecting serotype, but no or minimal inhibition was observed with other flaviviruses, including Japanese encephalitis virus, yellow fever virus, and Zika virus...
February 10, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29428678/profiling-cytokine-levels-in-chlorhexidine-and-egcg-treated-odontoblast-like-cells
#11
Alexander Terry Stavroullakis, Marcela Rocha Carrilho, Celine Marie Levesque, Anuradha Prakki
OBJECTIVE: To screen the effect of two compounds, chlorhexidine diacetate (CHX) and epigallocatechin-gallate (EGCG), on the levels of cytokines produced by odontoblast-like cells (MDPC-23). METHODS: Cells were seeded at 24h and 48h with serial dilution of the compounds to determine cell metabolic activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay (n=3). Cells with no compound treatment were used as control (Ctr). For the highest equal non-cytotoxic compound dilution tested at 48h cell treatment, total protein concentration was measured using a Pierce bicinchoninic acid (BCA) assay (n=3), and expression of 23 cytokines was analyzed using the Bio-Plex cytokine assay (n=2)...
February 7, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29427085/regulatory-effects-of-neuroinflammatory-responses-through-brain-derived-neurotrophic-factor-signaling-in-microglial-cells
#12
Sheng-Wei Lai, Jia-Hong Chen, Hsiao-Yun Lin, Yu-Shu Liu, Cheng-Fang Tsai, Pei-Chun Chang, Dah-Yuu Lu, Chingju Lin
Inhibition of microglial over-activation is an important strategy to counter balance neurodegenerative progression. We previously demonstrated that the adenosine monophosphate-activated protein kinase (AMPK) may be a therapeutic target in mediating anti-neuroinflammatory responses in microglia. Brain-derived neurotrophic factor (BDNF) is one of the major neurotrophic factors produced by astrocytes to maintain the development and survival of neurons in the brain, and have recently been shown to modulate homeostasis of neuroinflammation...
February 9, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29423494/egcg-evokes-nrf2-nuclear-translocation-and-dampens-ptp1b-expression-to-ameliorate-metabolic-misalignment-under-insulin-resistance-condition
#13
Yashi Mi, Wentong Zhang, Haoyu Tian, Runnan Li, Shuxian Huang, Xingyu Li, Guoyuan Qi, Xuebo Liu
As a major nutraceutical component of green tea (-)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists due to its well-documented antioxidant and antiobesity bioactivities. In the current study, we aimed to investigate the protective effect of EGCG on metabolic misalignment and in balancing the redox status in mice liver and HepG2 cells under insulin resistance condition. Our results indicated that EGCG accelerates the glucose uptake and evokes IRS-1/Akt/GLUT2 signaling pathway via dampening the expression of protein tyrosine phosphatase 1B (PTP1B)...
February 9, 2018: Food & Function
https://www.readbyqxmd.com/read/29419571/ameliorative-effect-of-epigallocatechin-gallate-on-cardiac-hypertrophy-and-fibrosis-in-aged-rats
#14
Ibrahim Muhammed, Suruthi Sankar, Sakthivel Govindaraj
The objective of the present study is to evaluate the effect of epigallocatechin gallate (EGCG) on aging-mediated cardiac hypertrophy, fibrosis, and apoptosis. The Wistar albino rats were divided into 4 groups (n = 18). Group I: young (3 months), group II: aged (24-26 months), group III: aged + EGCG (200 mg/kg for 30 days), and group IV: young + EGCG. At the end of 30 days, EGCG administration to the aged animals showed significant (P < 0.001) reduction of low-density lipoprotein, very low-density lipoprotein, triglyceride, total cholesterol with concomitant increase of high-density lipoprotein (P < 0...
February 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29416619/the-inhibitory-activity-of-gallic-acid-against-dna-methylation-application-of-gallic-acid-on-epigenetic-therapy-of-human-cancers
#15
Yui-Ping Weng, Pin-Feng Hung, Wen-Yen Ku, Chang-Yuan Chang, Bo-Han Wu, Ming-Han Wu, Jau-Ying Yao, Ji-Rui Yang, Chia-Huei Lee
Epigenome aberrations have been observed in tobacco-associated human malignancies. (-)-epigallocatechin-3-gallate (EGCG) has been proven to modulate gene expression by targeting DNA methyltransferases (DNMTs) through a proposed mechanism involving the gallate moiety of EGCG. We show that gallic acid (GA) changes the methylome of lung cancer and pre-malignant oral cell lines and markedly reduces both nuclear and cytoplasmic DNMT1 and DNMT3B within 1 week. GA exhibits stronger cytotoxicity against the lung cancer cell line H1299 than EGCG...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415993/evaluation-of-autophagy-inducers-in-epithelial-cells-carrying-the-%C3%AE-f508-mutation-of-the-cystic-fibrosis-transmembrane-conductance-regulator-cftr
#16
Shaoyi Zhang, Gautier Stoll, José Manuel Bravo San Pedro, Valentina Sica, Allan Sauvat, Florine Obrist, Oliver Kepp, Yousheng Li, Luigi Maiuri, Naoufal Zamzami, Guido Kroemer
Cystic Fibrosis (CF) due to the ΔF508 mutation of cystic fibrosis transmembrane conductance regulator (CFTR) can be treated with a combination of cysteamine and Epigallocatechin gallate (EGCG). Since ECGC is not a clinically approved drug, we attempted to identify other compounds that might favourably interact with cysteamine to induce autophagy and thus rescuing the function of ΔF508 CFTR as a chloride channel in the plasma membrane. For this, we screened a compound library composed by chemically diverse autophagy inducers for their ability to enhance autophagic flux in the presence of cysteamine...
February 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29411841/real-time-monitoring-of-the-aggregation-of-alzheimer-s-amyloid-%C3%AE-via1h-magic-angle-spinning-nmr-spectroscopy
#17
Jian Wang, Tomoya Yamamoto, Jia Bai, Sarah J Cox, Kyle J Korshavn, Martine Monette, Ayyalusamy Ramamoorthy
Proton magic-angle-spinning NMR used for real-time analysis of amyloid aggregation reveals that mechanical rotation of Aβ1-40 monomers increases the rate of formation of aggregates, and that the increasing lag-time with peptide concentration suggests the formation of growth-incompetent species. EGCG's ability to shift off-pathway aggregation is also demonstrated.
February 7, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29410209/grp78-protects-cho-cells-from-ribosylation
#18
Beibei Wu, Lexiang Yu, Pingdong Hu, Yang Lu, Juan Li, Yan Wei, Rongqiao He
d-ribose (Rib), a reactive glycation compound that exists in organisms, abnormally increases in the urine of diabetic patients and can yield large amounts of advanced glycation end products (AGEs), leading to cell dysfunction. However, whether cellular proteins are sensitive to this type of glycation is unknown. In this study, we found that cellular AGEs accumulate in Chinese hamster ovary (CHO) cells with increased Rib concentration and administration time. Mass spectrum analysis of isolated AGE-modified proteins from cell lysates showed that glucose-regulated protein 78 kD (GRP78) is one of the main ribosylated proteins...
February 1, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29407769/biophysical-evidence-for-differential-gallated-green-tea-catechins-binding-to-membrane-type-1-matrix-metalloproteinase-and-its-interactors
#19
Djahida Djerir, Mustapha Iddir, Steve Bourgault, Sylvie Lamy, Borhane Annabi
Membrane type-1 matrix metalloproteinase (MT1-MMP) is a transmembrane MMP which triggers intracellular signaling and regulates extracellular matrix proteolysis, two functions that are critical for tumor-associated angiogenesis and inflammation. While green tea catechins, particularly epigallocatechin gallate (EGCG), are considered very effective in preventing MT1-MMP-mediated functions, lack of structure-function studies and evidence regarding their direct interaction with MT1-MMP-mediated biological activities remain...
January 25, 2018: Biophysical Chemistry
https://www.readbyqxmd.com/read/29402411/epigallocatechin-3-gallate-attenuates-acute-and-chronic-psoriatic-itch-in-mice-involvement-of-antioxidant-anti-inflammatory-effects-and-suppression-of-erk-and-akt-signaling-pathways
#20
Ran Guo, Feng-Ming Zhou, Cun-Jin Su, Teng-Teng Liu, Yan Zhou, Li Fan, Zhi-Hong Wang, Xu Liu, Ya Huang, Tong Liu, Jianping Yang, Li-Hua Chen
Chronic itch is a distressing symptom of many skin diseases and negatively impacts quality of life. However, there is no medication for most forms of chronic itch, although antihistamines are often used for anti-itch treatment. Epigallocatechin-3-gallate (EGCG), a major green tea polyphenol, exhibits anti-oxidative and anti-inflammatory properties. Our previous studies highlighted a key role of oxidative stress and proinflammatory cytokines in acute and chronic itch. Here, we evaluated the effects of green tea polyphenon 60 and EGCG on acute and chronic itch in mouse models and explored its potential mechanisms...
February 1, 2018: Biochemical and Biophysical Research Communications
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