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https://www.readbyqxmd.com/read/29050464/anti-platelet-effects-of-epigallocatechin-3-gallate-in-addition-to-the-concomitant-aspirin-clopidogrel-or-ticagrelor-treatment
#1
Hyung Joon Joo, Ji-Young Park, Soon Jun Hong, Kyoung-Ah Kim, Seung Hoon Lee, Jae-Young Cho, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Background/Aims: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in addition to current anti-platelet medications remains to be elucidated. Methods: Blood samples were obtained from 40 participants who took aspirin (ASA, n = 10), clopidogrel (CPD, n = 10), ticagrelor (TCG, n = 10) and no anti-platelet medication (Control, n = 10)...
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29042941/epigallocatechin-gallate-inhibits-the-growth-and-promotes-the-apoptosis-of-bladder-cancer-cells
#2
Chenchen Feng, Yatfaat Ho, Chuanyu Sun, Guowei Xia, Qiang Ding, Bin Gu
Epigallocatechin gallate (EGCG) has been revealed to inhibit the proliferation and induce the apoptosis of several types of tumor, in addition to inhibiting DNA methyltransferase activity, leading to CpG demethylation. Tissue factor pathway inhibitor 2 (TFPI-2) expression is downregulated in bladder cancer. The present study revealed that this downregulation was partly due to hypermethylation of the TFPI-2 gene promoter, which was decreased by EGCG treatment. In addition, the present study demonstrated that EGCG could inhibit the viability and invasion, and induce the apoptosis, of bladder cancer T24 cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040973/sulforaphane-and-epigallocatechin-gallate-restore-estrogen-receptor-expression-by-modulating-epigenetic-events-in-the-breast-cancer-cell-line-mda-mb-231-a-systematic-review-and-meta-analysis
#3
Vincenza Gianfredi, Samuele Vannini, Massimo Moretti, Milena Villarini, Nicola Luigi Bragazzi, Alberto Izzotti, Daniele Nucci
BACKGROUND/AIMS: Epigenetics refers to modifications in gene activity and expression without alteration at the DNA sequence. Environment and diet could influence gene expression. Diet modifications may be meaningful in preventing and treating chronic diseases, cancer included. Dietary bioactive compounds, such as polyphenols (e.g., curcumin, resveratrol, or epigallocatechin gallate [EGCG]) or isothiocyanate (e.g., sulforaphane [SFN]), can regulate histone acetylation. The aim of this systematic review and meta-analysis was to evaluate the effect of SFN and EGCG on breast cancer (BC) cells cultured in vitro...
October 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29040955/protective-role-of-epigallocatechin-3-gallate-on-arsenic-induced-testicular-toxicity-in-swiss-albino-mice
#4
Pushpa Rani Guvvala, Janivara Parameswaraiah Ravindra, Chukkath Vijayan Rajani, Muniandy Sivaram, Sellappan Selvaraju
Arsenic, often referred to as the king of poisons is carcinogenic in humans and animals. It affects multiorgan systems including reproduction. The present study was undertaken to explore the protective role of green tea compound, epigallocatechin-3-gallate (EGCG) on arsenic induced testicular toxicity in Swiss albino mice. Thirty two adult male mice were randomly assigned to four groups (n=8). Group I served as control without test chemical. The group II received arsenic (200ppm) through drinking water, group III received only EGCG (20mg/kgb...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29037724/nanoemulsion-delivery-system-of-tea-polyphenols-enhanced-the-bioavailability-of-catechins-in-rats
#5
Yunru Peng, Qilu Meng, Jie Zhou, Bo Chen, Junjun Xi, Piaopiao Long, Liang Zhang, Ruyan Hou
Tea polyphenols (TP) were emulsified with corn oil and polysorbate 80 by high-pressure homogenization. The oil in water (O/W) TP nanoemulsion had droplet sizes of 99.42±1.25nm after preparation. The TP nanoemulsion was stable during storage at 4, 25 or 40°C for 20days. An in vitro simulated digestion assay showed that the bioaccessibility of (-)-epigallocatechin gallate (EGCG) was increased in the nanoemulsion compared to that in aqueous solution, but that the bioaccessibilities of (-)-epigallocatechin (EGC), (-)-epicatechin (EC) and (-)-gallocatechin gallate (GCG) were greatly decreased...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29037673/effect-of-epigallocatechin-gallate-egcg-extracted-from-green-tea-in-reducing-the-formation-of-acrylamide-during-the-bread-baking-process
#6
Zhengjie Fu, Michelle J Y Yoo, Weibiao Zhou, Lei Zhang, Yutao Chen, Jun Lu
This is the first study to investigate the extent of reduction in acrylamide formation during baking with the addition of (-)-epigallocatechin gallate (EGCG) extracted from green tea, and to determine whether EGCG influences the texture and colour attributes of bread, or interacts with other ingredients. EGCG powders were added to white bread formulations at the concentrations of 3.3, 6.6 and 9.9g·kg(-1). The amount of acrylamide in the bread was analysed using liquid chromatography-mass spectrometry. EGCG addition significantly reduced the acrylamide formation by 37% compared to the control and decreased the moisture content of the bread by 6%...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29032114/epigallocatechin-3-gallate-reduces-the-proliferation-of-benign-prostatic-hyperplasia-cells-via-regulation-of-focal-adhesions
#7
Burcu Erbaykent Tepedelen, Elif Soya, Mehmet Korkmaz
AIMS: Benign prostatic hyperplasia (BPH) is the most common urological disease that is characterized by the excessive growth of prostatic epithelial and stromal cells. Pharmacological therapy for BPH has limited use due to the many side effects so there is a need for new agents including natural compounds such as epigallocatechin-3-gallate (EGCG). This study was undertaken to assess the role of EGCG, suppressing the formation of BPH by reducing inflammation and oxidative stress, in cytoskeleton organization and ECM interactions via focal adhesions...
October 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29031698/aggregation-of-a%C3%AE-17-36-in-the-presence-of-naturally-occurring-phenolic-inhibitors-using-coarse-grained-simulations
#8
Yiming Wang, David C Latshaw, Carol K Hall
Although some naturally-occurring polyphenols have been found to inhibit amyloid β fibril formation and reduce neuron cell toxicity in vitro, their exact inhibitory mechanism is unknown. In this work, discontinuous molecular dynamics (DMD) combined with the PRIME20 force field and a newly-built inhibitor model are performed to examine the effect of vanillin, resveratrol, curcumin and epigallocatechin-3-gallate (EGCG) on the aggregation of Aβ(17-36) peptides. Four sets of peptide/inhibitor simulations are performed in which inhibitors: (1) bind to Aβ(17-36) monomer; (2) interfere with Aβ(17-36) oligomerization; (3) disrupt a pre-formed Aβ(17-36) protofilament; (4) prevent the growth of Aβ(17-36) protofilament...
October 12, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29029432/the-involvement-of-nrf2-in-the-protective-effects-of-epigallocatechin-3-gallate-egcg-on-naaso2-induced-hepatotoxicity
#9
Xiao-Dong Han, Yan-Yan Zhang, Ke-Lei Wang, Yong-Pan Huang, Zhong-Bao Yang, Zhi Liu
Arsenic exposure produces hepatotoxicity. The common mechanism determining its toxicity is the generation of oxidative stress. Oxidative stress induced by arsenic leads to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. (-)-Epigallocatechin-3-gallate (EGCG) possesses a potent antioxidant capacity and exhibits extensive pharmacological activities. This study aims to evaluate effects of EGCG on arsenic-induced hepatotoxicity and activation of Nrf2 pathway. Plasma activities of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and lactate dehydrogenase were measured; Histological analyses were conducted to observe morphological changes; Biochemical indexes such as oxidative stress (Catalase (CAT), malonyldialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), reactive oxygen species (ROS)), Nrf2 signaling related genes (Nrf2, Nqo1, and Ho-1) were assessed...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028073/polyphenol-epigallocatechin-3-gallate-alleviates-high-glucose-induced-h9c2-cell-damage-through-pi3k-akt-pathway
#10
Z-M Wang, C-Y Zhong, G-J Zhao
OBJECTIVE: The aim of this work was to study the protective effect of polyphenol epigallocatechin-3-gallate (EGCG) on high glucose-induced oxidative damage of H9C2 cells and to investigate the relationship between this effect and phosphatidyl inositol 3 kinase-serine/threonine kinase (P13K/Akt) signal transduction pathway. MATERIALS AND METHODS: H9C2 cells were used as objects of study, 350 mM glucose serum-free medium was used as the high glucose molding condition, and LY294002 (10 μM) was used as the PI3K/Akt inhibitor...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026297/in-vitro-study-on-anti-inflammatory-effects-of-epigallocatechin-3-gallate-loaded-nano-and-microscale-particles
#11
Yan Ru Wu, Hong Jin Choi, Yun Gyeong Kang, Jeong Koo Kim, Jung-Woog Shin
PURPOSE: This study aimed to develop an anti-inflammation system consisting of epigallo-catechin-3-gallate (EGCG) encapsulated in poly(lactide-co-glycolic acid) (PLGA) particles to promote wound healing. METHODS: Nano- and microscale PLGA particles were fabricated using a water/oil/water emulsion solvent evaporation method. The optimal particle size was determined based on drug delivery efficiency and biocompatibility. The particles were loaded with EGCG. The anti-inflammatory effects of the particles were evaluated in an in vitro cell-based inflammation model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29024813/a-prodrug-of-green-tea-polyphenol-epigallocatechin-3-gallate-pro-egcg-serves-as-a-novel-angiogenesis-inhibitor-in-endometrial-cancer
#12
Jianzhang Wang, Gene Chi Wai Man, Tak Hang Chan, Joseph Kwong, Chi Chiu Wang
Anti-angiogenesis effect of a prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) in malignant tumors is not well studied. Here, we investigated how the treatment with Pro-EGCG inhibited tumor angiogenesis in endometrial cancer. Tumor xenografts of human endometrial cancer were established and subjected to microarray analysis after Pro-EGCG treatment. First, we showed Pro-EGCG inhibited tumor angiogenesis in xenograft models through down-regulation of vascular endothelial growth factor A (VEGFA) and hypoxia inducible factor 1 alpha (HIF1α) in tumor cells and chemokine (C-X-C motif) ligand 12 (CXCL12) in host stroma by immunohistochemical staining...
October 9, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29017913/the-use-of-natural-compounds-for-the-targeting-and-chemoprevention-of-ovarian-cancer
#13
Francesca Pistollato, Ruben Calderón Iglesias, Roberto Ruiz, Silvia Aparicio, Jorge Crespo, Luis Dzul Lopez, Francesca Giampieri, Maurizio Battino
Among gynaecological cancers, ovarian cancer represents the leading cause of death in women. Current treatment for ovarian cancer entails surgery followed by combined chemotherapy with platinum and taxane, which are associated, particularly cisplatin, with severe side effects. While this treatment approach appears to be initially effective in a high number of patients, nearly 70% of them suffer a relapse within a few months after initial treatment. Therefore, more effective and better-tolerated treatment options are clearly needed...
October 7, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28992589/epigallocatechin-3-gallate-promotes-healthy-lifespan-through-mitohormesis-during-early-to-mid-adulthood-in-caenorhabditis-elegans
#14
Li-Gui Xiong, Yi-Jun Chen, Jie-Wen Tong, Yu-Shun Gong, Jian-An Huang, Zhong-Hua Liu
The green tea polyphenol epigallocatechin-3-gallate (EGCG) is widely consumed as a dietary supplement. Its potential properties include slowing aging and extending lifespan, although how exactly this is achieved remains unclear. Here, we report that EGCG promoted healthy lifespan in Caenorhabditis elegans when administered throughout or only at early-to-mid adulthood. Specifically, EGCG extended lifespan in an inverted U-shaped dose-response manner. The life-extending mechanism was stimulated by EGCG-induced production of reactive oxygen species (ROS)...
September 29, 2017: Redox Biology
https://www.readbyqxmd.com/read/28987359/in%C3%A2-vitro-assay-to-estimate-tea-astringency-via-observing-flotation-of-artificial-oil-bodies-sheltered-by-caleosin-fused-with-histatin-3
#15
Yu-En Shih, Yu-Chih Lin, Tse-Yu Chung, Mei-Chun Liu, Guan-Heng Chen, Chia-Chang Wu, Jason T C Tzen
Astringency, a sensory characteristic of food and beverages rich in polyphenols, mainly results from the formation of complexes between polyphenols and salivary proteins, causing a reduction of the lubricating properties of saliva. To develop an in vitro assay to estimate the astringency of oolong tea infusion, artificial oil bodies were constituted with sesame oil sheltered by a modified caleosin fused with histatin 3, one of the human salivary small peptides. Aggregation of artificial oil bodies was induced when they were mixed with oolong tea infusion or its major polyphenolic compound, (-)-epigallocatechin gallate (EGCG) of 100μM as observed in light microscopy...
October 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28984112/effects-of-green-tea-epigallocatechin-3-gallate-on-the-proteolipid-protein-and-oligodendrocyte-transcription-factor-1-messenger-rna-gene-expression-in-a-mouse-model-of-multiple-sclerosis
#16
Mohammadreza Semnani, Farhad Mashayekhi, Mahnaz Azarnia, Zivar Salehi
The cuprizone multiple sclerosis (MS) animal model is characteristic for toxic demyelination and represents a reversible demyelination and remyelination system. It has been shown that green tea epigallocatechin-3-gallate (EGCG) might be effective in improving the symptoms and pathological conditions associated with autoimmune inflammatory diseases in several animal models. In this study the effects of EGCG on proteolipid protein (PLP) and oligodendrocyte transcription factor 1 (Olig1) expression in the cerebral cortex of a murine model of cuprizone-induced demyelination was investigated...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28974447/synergistic-toxicity-of-epigallocatechin-3-gallate-and-diethyldithiocarbamate-a-lethal-encounter-involving-redox-active-copper
#17
Ke Zhang, Ruixia Dong, Kang Sun, Xiaoxiao Wang, Jiajia Wang, Chung S Yang, Jinsong Zhang
Dithiocarbamates (DTC) are widely used in agricultural, industrial and therapeutic domains. There are ample opportunities for human exposure to DTC. Green tea extracts, with epigallocatechin-3-gallate (EGCG) being the most abundant constituent, have been used as dietary supplements for body weight reduction. Our hypothesis is that DTC can act as a copper ionophore to increase hepatic levels of redox-active copper which promotes EGCG auto-oxidation to produce oxidative stress and toxicity. The results of the present study in a mouse model is consistent with this hypothesis, showing that co-administration of EGCG and diethyldithiocarbamate - a metabolite of disulfiram (a drug for alcohol aversion therapy), both at tolerable levels, caused lethality...
September 30, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28969057/the-construction-of-the-multifunctional-targeting-ursolic-acids-liposomes-and-its-apoptosis-effects-to-c6-glioma-stem-cells
#18
Xue Ying, Yahua Wang, Haolun Xu, Xia Li, Helu Yan, Hui Tang, Chen Wen, Yingchun Li
Brain gliomas, one of the most fatal tumors to human, severely threat the health and life of human. They are capable of extremely strong invasion ability. And invasive glioma cells could rapidly penetrate into normal brain tissues and break them. We prepared a kind of functional liposomes, which could be transported acrossing the blood-brain barrier (BBB) and afterwards induce the apoptosis of glioma stem cells. In this research, we chose ursolic acids (UA) as an anti-cancer drug to inhibit the growth of C6 glioma cells, while epigallocatechin 3-gallate(EGCG) as the agent that could induce the apoptosis of C6 glioma stem cells...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967875/combination-curcumin-and-epigallocatechin-3-gallate-inhibits-colorectal-carcinoma-microenvironment-induced-angiogenesis-by-jak-stat3-il-8-pathway
#19
G Jin, Y Yang, K Liu, J Zhao, X Chen, H Liu, R Bai, X Li, Y Jiang, X Zhang, J Lu, Z Dong
Tumor microenvironment has a crucial role in cancer development and progression, whereas the mechanism of how it regulates angiogenesis is unclear. In this study, we simulated the colorectal carcinoma microenvironment by conditioned medium (CM) of colorectal carcinoma cell lines (SW620, HT-29, HCT116) supernatant or colorectal carcinoma tissue homogenate supernatant to induce normal endothelial cells (NECs). We found that colorectal carcinoma CM promoted tumor angiogenesis by coercing NECs toward tumor endothelial cells (TECs) with the activation of the JAK/STAT3 signaling pathway...
October 2, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28964574/epigallocatechin-3-gallate-promotes-apoptosis-and-reversal-of-multidrug-resistance-in-esophageal-cancer-cells
#20
Liang Liu, Yingchao Ju, Jing Wang, Rongmiao Zhou
Evidence for demonstrating the role of the green tea component epigallocatechin-3-gallate (EGCG) in esophageal squamous cell carcinoma cells is limited. In this study, we investigated apoptosis induced by EGCG and the underlying molecular mechanisms in human esophageal squamous cell carcinoma cells. The growth-inhibitory effects of EGCG on esophageal cancer cell (Eca109 and Ec9706) were detected by MTT. Using flow cytometry, we determined the cellular apoptosis, bcl-2, bax and caspase-3 protein expression in Eca109 and Ec9706 cells following treatment with EGCG for 24h...
September 12, 2017: Pathology, Research and Practice
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