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Keywords insulin resistance depression ...

insulin resistance depression randomized

https://read.qxmd.com/read/36292553/a-non-randomized-combined-program-of-walking-and-low-load-resistance-exercise-improves-cognitive-function-and-cardiometabolic-risk-factors-in-community-dwelling-elderly-women
#21
JOURNAL ARTICLE
Jeonghyeon Kim, Seamon Kang, Haeryun Hong, Mingyu Joo, Hyunsik Kang
BACKGROUND: This study examines whether changes in cardiometabolic risk factors, functional fitness, and depressive symptoms following a six-month exercise intervention were associated with cognitive function in Korean women aged 65 years and older. METHODS: A non-randomized study design was used to compare post-intervention changes in measured variables between control ( n = 30) and exercise ( n = 30) groups. The exercise intervention consisted of three days of low-load resistance exercise and two days of walking...
October 21, 2022: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/36266683/effects-of-vitamin-d-on-insulin-resistance-and-fasting-blood-glucose-in-pregnant-women-with-insufficient-or-deficient-vitamin-d-a-randomized-placebo-controlled-trial
#22
RANDOMIZED CONTROLLED TRIAL
Zahra Mirzaei-Azandaryani, Sakineh Mohammad-Alizadeh-Charandabi, Elnaz Shaseb, Shamsi Abbasalizadeh, Mojgan Mirghafourvand
BACKGROUND: Gestational diabetes is one of the most common metabolic disorders during pregnancy. Some studies have reported the effect of vitamin D deficiency on the incidence of this disorder. Therefore, the purpose of the present study was to determine the effect of vitamin D supplementation on fasting blood glucose (FBG) levels, fasting blood insulin (FBI) levels and insulin resistance index (HOMA-IR) (primary outcomes) and symptoms of depression, musculoskeletal pain, frequency of gestational diabetes and the frequency of abortion (secondary outcomes)...
October 20, 2022: BMC Endocrine Disorders
https://read.qxmd.com/read/36239189/effect-of-faecal-microbial-transplant-via-colonoscopy-in-patients-with-severe-obesity-and-insulin-resistance-a-randomized-double-blind-placebo-controlled-phase-2-trial
#23
JOURNAL ARTICLE
Yasaman Ghorbani, Katherine J P Schwenger, Divya Sharma, Hyejung Jung, Jitender Yadav, Wei Xu, Wendy Lou, Susan Poutanen, Susy S Hota, Elena M Comelli, Dana Philpott, Timothy D Jackson, Allan Okrainec, Herbert Y Gaisano, Johane P Allard
AIM: To assess the effects of faecal microbial transplant (FMT) from lean people to subjects with obesity via colonoscopy. MATERIAL AND METHODS: In a double-blind, randomized controlled trial, subjects with a body mass index ≥ 35 kg/m2 and insulin resistance were randomized, in a 1:1 ratio in blocks of four, to either allogenic (from healthy lean donor; n = 15) or autologous FMT (their own stool; n = 13) delivered in the caecum and were followed for 3 months...
October 14, 2022: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/36235570/effects-of-branched-chain-amino-acids-on-skeletal-muscle-glycemic-control-and-neuropsychological-performance-in-elderly-persons-with-type-2-diabetes-mellitus-an-exploratory-randomized-controlled-trial
#24
RANDOMIZED CONTROLLED TRIAL
Takaaki Matsuda, Hiroaki Suzuki, Yoko Sugano, Yasuhiro Suzuki, Daisuke Yamanaka, Risa Araki, Naoya Yahagi, Motohiro Sekiya, Yasushi Kawakami, Yoshinori Osaki, Hitoshi Iwasaki, Koichi Hashimoto, Shin-Ichiro Takahashi, Yasushi Hada, Hitoshi Shimano
Although branched-chain amino acids (BCAA) are known to stimulate myofibrillar protein synthesis and affect insulin signaling and kynurenine metabolism (the latter being a metabolite of tryptophan associated with depression and dementia), the effects of BCAA supplementation on type 2 diabetes (T2D) are not clear. Therefore, a 24-week, prospective randomized open blinded-endpoint trial was conducted to evaluate the effects of supplementation of 8 g of BCAA or 7.5 g of soy protein on skeletal muscle and glycemic control as well as adverse events in elderly individuals with T2D...
September 21, 2022: Nutrients
https://read.qxmd.com/read/36117653/depression-in-polycystic-ovary-syndrome-focusing-on-pathogenesis-and-treatment
#25
REVIEW
Liwei Xing, Jinlong Xu, Yuanyuan Wei, Yang Chen, Haina Zhuang, Wei Tang, Shun Yu, Junbao Zhang, Guochen Yin, Ruirui Wang, Rong Zhao, Dongdong Qin
Polycystic ovary syndrome (PCOS) is one of the most prevalent gynecological endocrine conditions affecting reproductive women. It can feature a variety of symptoms, such as obesity, insulin resistance, skin conditions, and infertility. Women with PCOS are susceptible to illnesses including mood disorders, diabetes, hypertension, and dyslipidemia. Among them, depression is the most common in PCOS and has a detrimental effect on quality of life. Depression may occasionally develop due to the pathological traits of PCOS, but its exact pathogenesis in PCOS have eluded researchers to date...
2022: Frontiers in Psychiatry
https://read.qxmd.com/read/36108715/mechanistic-insights-into-the-protective-role-of-eugenol-against-stress-induced-reproductive-dysfunction-in-female-rat-model
#26
JOURNAL ARTICLE
Hebatullah Helmy, Nermin Abdel Hamid Sadik, Laila Badawy, Noha H Sayed
The challenging and highly demanding life rhythm nowadays subjects people to unavoidable chronic stress. Chronic stress is associated with a wide array of serious health complications including neuroendocrine dysregulations. Women are more prone to chronic stress-related hormonal disturbances and their physical and psychological consequences, especially reproductive impairment. Eugenol is a natural phenolic anti-oxidant that has several beneficial biological activities. The current study intended to scrutinize the potential protective effect of eugenol in female Wistar rats exposed to chronic unpredictable mild stress (CUMS)...
September 12, 2022: Chemico-biological Interactions
https://read.qxmd.com/read/35704147/long-term-high-fat-diet-induces-metabolic-disorders-and-aggravates-behavioral-disorders-and-cognitive-deficits-in-mapt-p301l-transgenic-mice
#27
JOURNAL ARTICLE
Jing Xiong, Isaac Deng, Sally Kelliny, Liying Lin, Larisa Bobrovskaya, Xin-Fu Zhou
Most Alzheimer disease (AD) patients present as sporadic late onset AD, with metabolic factors playing an important role in the occurrence and development of AD. Given the link between peripheral insulin resistance and tau pathology in streptozotocin-injected and db/db mouse models of diabetes, we fed high fat diet (HFD) to pR5 mice expressing P301L mutant human tau, with the aim of developing a new model with characteristics of obesity, T2DM and AD to mimic AD patients exacerbated by obesity and T2DM, an increasing trend in modern society...
August 2022: Metabolic Brain Disease
https://read.qxmd.com/read/35685534/the-effects-of-probiotic-supplementation-on-opioid-related-disorder-in-patients-under-methadone-maintenance-treatment-programs
#28
JOURNAL ARTICLE
Nader Molavi, Morad Rasouli-Azad, Hamed Mirzaei, Amir Hassan Matini, Hamid Reza Banafshe, Marjan Valiollahzadeh, Majid Hassanzadeh, Ahmad Reza Saghazade, Samira Abbaszadeh-Mashkani, Peyman Mamsharifi, Amir Ghaderi
Introduction: Patients under methadone maintenance treatment programs (MMTPs) are susceptible to numerous complications (e.g., mental and metabolic disorders). This study evaluated the effects of probiotics on clinical symptoms, biomarkers of oxidative stress, inflammation, insulin resistance, and serum lipid content in patients receiving MMTPs. Materials and Methods: A randomized, double-blind, placebo-controlled trial was conducted among 70 patients receiving MMTPs to receive either 1...
2022: International Journal of Clinical Practice
https://read.qxmd.com/read/35587078/effect-of-laser-biostimulation-and-a-low-calorie-diet-vs-a-low-calorie-diet-alone-on-insulin-resistance-inflammatory-biomarkers-and-depression-among-obese-postmenopausal-women-a-randomized-controlled-trial
#29
RANDOMIZED CONTROLLED TRIAL
M M Elsayed, M Rakha, H A Elsheimy, N E Abdelaziz, E N Nagy
OBJECTIVE: Postmenopausal women are significantly predisposed to a multitude of disorders. Laser biostimulation (LB) and a healthy diet have been linked to multiple health benefits. This study aimed to investigate the effect of a combined LB and balanced low-calorie diet (LCD) vs. an LCD alone on insulin resistance (IR), inflammatory biomarkers, and depression score in obese postmenopausal women. PATIENTS AND METHODS: In the present study, a total of 66 postmenopausal women, with a mean age of 66...
May 2022: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/35367918/examining-cognitive-behavioral-therapy-change-mechanisms-for-decreasing-depression-weight-and-insulin-resistance-in-adolescent-girls-at-risk-for-type-2-diabetes
#30
RANDOMIZED CONTROLLED TRIAL
Lauren D Gulley, Lauren B Shomaker, Nichole R Kelly, Kong Y Chen, Cara H Olsen, Marian Tanofsky-Kraff, Jack A Yanovski
OBJECTIVE: Depression in adolescence is linked to risk for type 2 diabetes (T2D). In this secondary data analysis of a randomized controlled trial comparing cognitive-behavioral therapy (CBT) to a control program to ameliorate insulin resistance via reducing depression symptoms, we examine which CBT change mechanisms (e.g., behavioral activation, cognitive restructuring) contributed to decreased depression and subsequent improvements in body mass index (BMI), percent body fat, and insulin resistance...
June 2022: Journal of Psychosomatic Research
https://read.qxmd.com/read/35120288/treating-insulin-resistance-with-metformin-as-a-strategy-to-improve-clinical-outcomes-in-treatment-resistant-bipolar-depression-the-trio-bd-study-a-randomized-quadruple-masked-placebo-controlled-clinical-trial
#31
RANDOMIZED CONTROLLED TRIAL
Cynthia V Calkin, K N Roy Chengappa, Kathleen Cairns, Jacob Cookey, Jessica Gannon, Martin Alda, Claire O'Donovan, Claire Reardon, Marcos Sanches, Martina Růzicková
Objective: Therapeutic options are limited for treatment-resistant bipolar depression (TRBD). Insulin resistance (IR) confers increased risk for TRBD. We investigated metformin, an insulin sensitizer, to reverse IR and improve clinical outcomes in TRBD. Methods: Using a random-assignment (1:1), intent-to-treat, 2-site, quadruple-masked, parallel-group (metformin to 2,000 mg/d or placebo) clinical trial design, patients with DSM-5 bipolar disorder (BD) type I or II and IR received study medication for 26 weeks (February 2016 to October 2019)...
February 1, 2022: Journal of Clinical Psychiatry
https://read.qxmd.com/read/35094873/mendelian-randomization-analyses-for-pcos-evidence-opportunities-and-challenges
#32
REVIEW
Congying Wang, Wei Wu, Haiyan Yang, Zhenhong Ye, Yue Zhao, Jun Liu, Liangshan Mu
Identifying etiological risk factors is significant for preventing and treating patients with polycystic ovary syndrome (PCOS). Through genetic variation, Mendelian randomization (MR) assesses causal associations between PCOS risk and related exposure factors. This emerging technology has provided evidence of causal associations of anti-Müllerian hormone (AMH) levels, sex hormone-binding globulin (SHBG) levels, menopause age, adiposity, insulin resistance (IR), depression, breast cancer, ovarian cancer, obsessive-compulsive disorder (OCD), and forced vital capacity (FVC) with PCOS, while lacking associations of type 2 diabetes mellitus (T2DM), coronary heart disease (CHD), stroke, anxiety disorder (AD), schizophrenia (SCZ), bipolar disorder (BIP), and offspring birth weight with PCOS...
January 27, 2022: Trends in Genetics: TIG
https://read.qxmd.com/read/34970669/nutritional-supplements-and-complementary-therapies-in-polycystic-ovary-syndrome
#33
REVIEW
Simon Alesi, Carolyn Ee, Lisa J Moran, Vibhuti Rao, Aya Mousa
Polycystic ovary syndrome (PCOS) affects 1 in 5 women of reproductive age, and is characterized by menstrual irregularities, clinical or biochemical hyperandrogenism, and the presence of polycystic ovary morphology. One of the recommended treatment strategies in the international evidence-based guidelines is lifestyle modification, which includes diet and exercise, with the aim of improving a range of health outcomes. The incurable nature of PCOS reinforces the importance of developing novel and innovative symptomatic relief strategies, which are currently the only available approaches for improving quality of life for these women...
August 1, 2022: Advances in Nutrition
https://read.qxmd.com/read/34962457/the-effect-of-vitamin-d-supplementation-on-tobacco-related-disorders-in-individuals-with-a-tobacco-use-disorder-a-randomized-clinical-trial
#34
JOURNAL ARTICLE
Soheil Bagheri, Ahmad Reza Saghazade, Samira Abbaszadeh-Mashkani, Hamid Reza Banafshe, Fatemeh Sadat Ghoreishi, Azam Mesdaghinia, Amir Ghaderi
Vitamin D deficiency in cigarette smokers (CS) might associate with several complications, including metabolic deficits, depression and anxiety. This study evaluated the effects of vitamin D on mental health symptoms, nicotine misuse, and biomarkers of metabolic diseases in individuals with a tobacco use disorder. A randomized, double-blind, placebo-controlled trial was conducted with 60 CS subjects receiving either 50,000 IU vitamin D supplements ( n  = 30) or placebo ( n  = 30) every 2 weeks for 24-weeks...
December 28, 2021: Journal of Addictive Diseases
https://read.qxmd.com/read/34492402/nonrespiratory-comorbidities-in-asthma
#35
REVIEW
Juan Carlos Cardet, Adeeb A Bulkhi, Richard F Lockey
Asthma is a chronic heterogeneous airway disease. Common comorbid conditions are often disproportionately present in severe asthma. Optimal care of patients with asthma requires the recognition and treatment of these comorbid conditions. This review outlines the pathophysiological mechanisms between nonrespiratory comorbid conditions and asthma and their effect on asthma outcomes. They include: type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease, adrenal and thyroid gland diseases, pregnancy, osteoporosis, adverse effects from medications, and mental health disorders...
November 2021: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/34461975/study-protocol-for-the-exercising-together%C3%A2-trial-a-randomized-controlled-trial-of-partnered-exercise-for-couples-coping-with-cancer
#36
JOURNAL ARTICLE
Kerri M Winters-Stone, Karen S Lyons, Nathan F Dieckmann, Christopher S Lee, Zahi Mitri, Tomasz M Beer
BACKGROUND: Most cancer survivors are married, and cancer strains the physical and mental health of each partner and their intimate relationship. We created a partnered strength training program, Exercising Together©, where the survivor and his/her partner exercise as a team in order to improve physical and mental health of both members of the couple as well as the quality of their relationship. We have not yet determined if Exercising Together© is similarly effective in couples coping with different types of cancer nor if training as a team has unique and added benefits over those derived from supervised group training and/or shared behavior change...
August 30, 2021: Trials
https://read.qxmd.com/read/34440563/targeting-metabolic-dysfunction-for-the-treatment-of-mood-disorders-review-of-the-evidence
#37
REVIEW
Brett D M Jones, Salman Farooqui, Stefan Kloiber, Muhammad Omair Husain, Benoit H Mulsant, Muhammad Ishrat Husain
Major depressive disorder (MDD) and bipolar disorder (BD) are often chronic with many patients not responding to available treatments. As these mood disorders are frequently associated with metabolic dysfunction, there has been increased interest in novel treatments that would target metabolic pathways. The objectives of this scoping review were to synthesize evidence on the impact on mood symptoms of lipid lowering agents and anti-diabetics drugs, while also reviewing current knowledge on the association between mood disorders and dyslipidemia or hyperglycemia...
August 11, 2021: Life
https://read.qxmd.com/read/34338703/co-supplementation-of-camelina-oil-and-a-prebiotic-is-more-effective-for-in-improving-cardiometabolic-risk-factors-and-mental-health-in-patients-with-nafld-a-randomized-clinical-trial
#38
RANDOMIZED CONTROLLED TRIAL
Maryam Kavyani, Sevda Saleh-Ghadimi, Parvin Dehghan, Mahdieh Abbasalizad Farhangi, Manouchehr Khoshbaten
This trial evaluated the effects of co-supplementing Camelina sativa oil (CSO) and a prebiotic as modulators of the gut microbiota on cardiometabolic risk factors and mental health in NAFLD patients. In all, 44 subjects with NAFLD were allocated to either an intervention (20 g d-1 CSO + resistant dextrin) or a placebo (20 g d-1 CSO + maltodextrin) group and received a calorie-restricted diet (-500 kcal d-1 ) for 12 weeks. Fasting plasma levels of gucose, insulin, hs-CRP, endotoxin, antioxidant enzyme activity, total antioxidant capacity (TAC), malondialdehyde (MDA), 8-iso-prostaglandin F2α, and uric acid were measured at the baseline and post-intervention...
September 20, 2021: Food & Function
https://read.qxmd.com/read/34260997/effects-of-tai-chi-on-health-outcomes-among-community-dwelling-adults-with-or-at-risk-of-metabolic-syndrome-a-systematic-review
#39
REVIEW
Janita Pak Chun Chau, Leona Yuen Ling Leung, Xu Liu, Suzanne Hoi Shan Lo, Kai Chow Choi, Jie Zhao, Helen Chung Yan Chiang
OBJECTIVES: This systematic review evaluated the effects of Tai Chi on health outcomes among community-dwelling adults with or at risk of metabolic syndrome (MetS). METHODS: Randomized controlled trials (RCTs) were searched in 10 databases. Data were statistically pooled for meta-analysis. RESULTS: Twenty RCTs were included. One study involved adults with MetS, and the other 19 studies involved adults with at least one risk factor for MetS...
August 2021: Complementary Therapies in Clinical Practice
https://read.qxmd.com/read/34180998/sleep-habits-of-women-with-infertility
#40
JOURNAL ARTICLE
Esther Eisenberg, Richard S Legro, Michael P Diamond, Hao Huang, Louise M O'Brien, Yolanda R Smith, Christos Coutifaris, Karl R Hansen, Nanette Santoro, Heping Zhang
CONTEXT: Sleep plays important roles in metabolic and reproductive function, and polycystic ovary syndrome (PCOS) is associated with sleep disturbances including increased prevalence of obstructive sleep apnea. OBJECTIVE: We sought to evaluate sleep parameters in infertile women with PCOS compared to women with unexplained infertility (UI) and identify risk factors for disturbed sleep. DESIGN: Prospective cohort of women diagnosed with PCOS or UI from two randomized clinical trials...
June 28, 2021: Journal of Clinical Endocrinology and Metabolism
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