keyword
MENU ▼
Read by QxMD icon Read
search

insulin resistance depression randomized

keyword
https://www.readbyqxmd.com/read/27669638/clinical-and-metabolic-response-to-probiotic-supplementation-in%C3%A2-patients-with-multiple-sclerosis-a-randomized-double-blind-placebo-controlled-trial
#1
Ebrahim Kouchaki, Omid Reza Tamtaji, Mahmoud Salami, Fereshteh Bahmani, Reza Daneshvar Kakhaki, Elmira Akbari, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Zatollah Asemi
BACKGROUND & AIMS: This trial was performed to evaluate the effects of probiotic intake on disability, mental health and metabolic condition in subjects with multiple sclerosis (MS). METHODS: This randomized double-blind placebo-controlled clinical trial was conducted among 60 MS patients. Participants were randomly allocated into two groups to receive either a probiotic capsule (n = 30) or placebo containing starch (n = 30) for 12 weeks. Expanded disability status scale (EDSS) scoring and parameters of mental health were recorded at the baseline and 12 weeks after the intervention...
September 16, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27333897/a-randomized-controlled-trial-to-prevent-depression-and-ameliorate-insulin-resistance-in-adolescent-girls-at-risk-for-type-2-diabetes
#2
Lauren B Shomaker, Nichole R Kelly, Courtney K Pickworth, Omni L Cassidy, Rachel M Radin, Lisa M Shank, Anna Vannucci, Katherine A Thompson, Sara A Armaiz-Flores, Sheila M Brady, Andrew P Demidowich, Ovidiu A Galescu, Amber B Courville, Cara Olsen, Kong Y Chen, Eric Stice, Marian Tanofsky-Kraff, Jack A Yanovski
BACKGROUND: Prospective data suggest depressive symptoms worsen insulin resistance and accelerate type 2 diabetes (T2D) onset. PURPOSE: We sought to determine whether reducing depressive symptoms in overweight/obese adolescents at risk for T2D would increase insulin sensitivity and mitigate T2D risk. METHOD: We conducted a parallel-group, randomized controlled trial comparing a 6-week cognitive-behavioral (CB) depression prevention group with a 6-week health education (HE) control group in 119 overweight/obese adolescent girls with mild-to-moderate depressive symptoms (Center for Epidemiological Studies-Depression Scale [CES-D] ≥16) and T2D family history...
October 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/27000685/testosterone-deprivation-accelerates-cardiac-dysfunction-in-obese-male-rats
#3
Wanpitak Pongkan, Hiranya Pintana, Sivaporn Sivasinprasasn, Thidarat Jaiwongkam, Siriporn C Chattipakorn, Nipon Chattipakorn
Low testosterone level is associated with increased risks of cardiovascular diseases. As obese-insulin-resistant condition could impair cardiac function and that the incidence of obesity is increased in aging men, a condition of testosterone deprivation could aggravate the cardiac dysfunction in obese-insulin-resistant subjects. However, the mechanism underlying this adverse effect is unclear. This study investigated the effects of obesity on metabolic parameters, heart rate variability (HRV), left ventricular (LV) function, and cardiac mitochondrial function in testosterone-deprived rats...
June 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/26939086/sertraline-inhibits-increases-in-body-fat-and-carbohydrate-dysregulation-in-adult-female-cynomolgus-monkeys
#4
Marnie G Silverstein-Metzler, Carol A Shively, Thomas B Clarkson, Susan E Appt, J Jeffrey Carr, Stephen B Kritchevsky, Sara R Jones, Thomas C Register
Selective serotonin reuptake inhibitor (SSRI) antidepressants are widely prescribed for depression and other disorders. SSRIs have become one of the most commonly used drugs in the United States, particularly by women. Acute effects on body composition and carbohydrate metabolism have been reported, but little is known regarding the effects of chronic SSRI use. We evaluated the effects of chronic administration of a commonly prescribed SSRI, sertraline HCl, on body weight and composition, fat distribution, carbohydrate metabolism, as well as activity, in adult female depressed and nondepressed cynomolgus monkeys (Macaca fascicularis; n=42) using a placebo-controlled, longitudinal, randomized study design...
June 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/26872112/a-naturalistic-randomized-placebo-controlled-trial-of-extended-release-metformin-to-prevent-weight-gain-associated-with-olanzapine-in-a-us-community-dwelling-population
#5
Jeffrey Rado, Stephanie von Ammon Cavanaugh
OBJECTIVE: This 24-week pilot study assessed the efficacy, tolerability, and safety of adjunctive metformin versus placebo for the prevention of olanzapine-associated weight gain in community-dwelling adult patients with schizophrenia, schizoaffective disorder, bipolar disorder, or major depression with psychotic features. METHODS: In a double-blind study, 25 patients were randomly assigned to receive 24 weeks of either olanzapine plus metformin or olanzapine plus placebo...
April 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/26706022/clinical-and-metabolic-response-to-probiotic-administration-in-patients-with-major-depressive-disorder-a-randomized-double-blind-placebo-controlled-trial
#6
RANDOMIZED CONTROLLED TRIAL
Ghodarz Akkasheh, Zahra Kashani-Poor, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Hossein Akbari, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi, Ahmad Esmaillzadeh
OBJECTIVE: We are aware of no study examining the effects of probiotic supplementation on symptoms of depression, metabolic profiles, serum high-sensitivity C-reactive protein (hs-CRP), and biomarkers of oxidative stress in patients with major depressive disorder (MDD). The present study was designed to determine the effects of probiotic intake on symptoms of depression and metabolic status in patients with MDD. METHODS: This randomized, double-blind, placebo-controlled clinical trial included 40 patients with a diagnosis of MDD based on DSM-IV criteria whose age ranged between 20 and 55 y...
March 2016: Nutrition
https://www.readbyqxmd.com/read/26609167/vitamin-d-supplementation-affects-the-beck-depression-inventory-insulin-resistance-and-biomarkers-of-oxidative-stress-in-patients-with-major-depressive-disorder-a-randomized-controlled-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Zahra Sepehrmanesh, Fariba Kolahdooz, Fatemeh Abedi, Navid Mazroii, Amin Assarian, Zatollah Asemi, Ahmad Esmaillzadeh
BACKGROUND: Vitamin D may decrease depression symptoms through its beneficial effects on neurotransmitters, metabolic profiles, biomarkers of inflammation, and oxidative stress. OBJECTIVE: This study was designed to assess whether vitamin D supplementation can reduce symptoms of depression, metabolic profiles, serum high-sensitivity C-reactive protein (hs-CRP), and biomarkers of oxidative stress in patients with major depressive disorder (MDD). METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed in 40 patients between 18 and 65 y of age with a diagnosis of MDD based on criteria from the Diagnostic and Statistical Manual of Mental Disorders...
February 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/26602230/adjuvant-pioglitazone-for-unremitted-depression-clinical-correlates-of-treatment-response
#8
RANDOMIZED CONTROLLED TRIAL
Kathleen Watson Lin, Tonita E Wroolie, Thalia Robakis, Natalie L Rasgon
Previous studies suggest that insulin-sensitizing agents could play a significant role in the treatment of major depression, particularly depression in patients with documented insulin resistance or those who are resistant to standard psychopharmacological approaches. This study aimed to assess the effects on depressive symptoms with adjuvant treatment with the PPARγ-agonist pioglitazone. Patients (N=37) with non-psychotic, non-remitting depression receiving standard psychiatric regimens for depression were randomized across an insulin sensitivity spectrum in a 12-week double blind, randomized controlled trial of pioglitazone or placebo...
December 30, 2015: Psychiatry Research
https://www.readbyqxmd.com/read/26531693/behavioral-and-systemic-consequences-of-long-term-inflammatory-challenge
#9
Christina W Fischer, Betina Elfving, Sten Lund, Gregers Wegener
Inflammatory reactions are involved in a diversity of diseases, including major depressive disorder. Cytokines act as intercellular signaling molecules and mediators of inflammation between the periphery and the brain. Within the brain, evidence from animal studies of acute inflammation has shown that elevated cytokine levels are linked to behavioral responses of sickness and depression-like behavior. Although chronic inflammation is more translational to human depression than acute studies, little is known on central cytokine expression and associated behavioral responses following chronic immune challenges...
November 15, 2015: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/26458923/rationale-and-design-of-the-adapted-physical-activity-in-advanced-pancreatic-cancer-patients-apacap-gercor-groupe-coop%C3%A3-rateur-multidisciplinaire-en-oncologie-trial-study-protocol-for-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Cindy Neuzillet, Mathieu Vergnault, Franck Bonnetain, Pascal Hammel
BACKGROUND: Exercise during chemotherapy is a promising strategy to reduce fatigue and improve health-related quality of life (HRQoL). It has been shown to be feasible and efficient in various cancers, including advanced-stage cancers. Effects of physical activity have never been explored in advanced pancreatic ductal adenocarcinoma (PDAC). We aim to evaluate the effects of an exercise intervention in this setting. METHODS: This randomized, national, multicenter, interventional study will examine the effectiveness of an unsupervised, home-based, 16-week adapted physical activity (APA) program...
October 12, 2015: Trials
https://www.readbyqxmd.com/read/26375919/a-20-week-program-of-resistance-or-concurrent-exercise-improves-symptoms-of-schizophrenia-results-of-a-blind-randomized-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Bruna Andrade E Silva, Ricardo C Cassilhas, Cecília Attux, Quirino Cordeiro, André L Gadelha, Bruno A Telles, Rodrigo A Bressan, Francine N Ferreira, Paulo H Rodstein, Claudiane S Daltio, Sérgio Tufik, Marco T de Mello
OBJECTIVE: To evaluate the effects of 20 weeks of resistance and concurrent training on psychotic and depressive symptoms, quality of life outcomes, and serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations in patients with schizophrenia. METHODS: In this blind, randomized controlled clinical trial, 34 patients with schizophrenia were assigned to one of three groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent exercise (CONCEX, n=9)...
October 2015: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/26246241/vitamin-d-supplementation-for-the-prevention-of-type-2-diabetes-in-overweight-adults-study-protocol-for-a-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Barbora de Courten, Aya Mousa, Negar Naderpoor, Helena Teede, Maximilian P J de Courten, Robert Scragg
BACKGROUND: Despite Australia's sunny climate, low vitamin D levels are increasingly prevalent. Sun exposure is limited by long working hours, an increase in time spent indoors, and sun protection practices, and there is limited dietary vitamin D fortification. While the importance of vitamin D for bone mineralization is well known, its role as a protective agent against chronic diseases, such as type 2 diabetes and cardiovascular disease, is less understood. Observational and limited intervention studies suggest that vitamin D might improve insulin sensitivity and secretion, mainly via its anti-inflammatory properties, thereby decreasing the risk of development and progression of type 2 diabetes...
August 7, 2015: Trials
https://www.readbyqxmd.com/read/26242295/the-link-between-obesity-and-vitamin-d-in-bariatric-patients-with-omega-loop-gastric-bypass-surgery-a-vitamin-d-supplementation-trial-to-compare-the-efficacy-of-postoperative-cholecalciferol-loading-load-study-protocol-for-a-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Maria Luger, Renate Kruschitz, Rodrig Marculescu, Helmuth Haslacher, Friedrich Hoppichler, Enikö Kallay, Christian Kienbacher, Carmen Klammer, Melanie Kral, Felix Langer, Eva Luger, Gerhard Prager, Michael Trauner, Stefan Traussnigg, Tanja Würger, Karin Schindler, Bernhard Ludvik
BACKGROUND: Beyond its classical role in calcium homoeostasis and bone metabolism, vitamin D deficiency has been found to be associated with several diseases, including diabetes, non-alcoholic fatty liver disease, and even obesity itself. Importantly, there are limited data on therapeutic strategies for vitamin D deficiency in bariatric patients, and the procedure-specific guidelines may not be sufficient. To improve long-term outcomes, nutritional screening and appropriate supplementation to prevent nutrient deficiencies are urgently needed...
August 5, 2015: Trials
https://www.readbyqxmd.com/read/26204994/light-therapy-for-better-mood-and-insulin-sensitivity-in-patients-with-major-depression-and-type-2-diabetes-a-randomised-double-blind-parallel-arm-trial
#14
RANDOMIZED CONTROLLED TRIAL
Annelies Brouwer, Daniël H van Raalte, Michaela Diamant, Femke Rutters, Eus J W van Someren, Frank J Snoek, Aartjan T F Beekman, Marijke A Bremmer
BACKGROUND: Major depression and type 2 diabetes often co-occur. Novel treatment strategies for depression in type 2 diabetes patients are warranted, as depression in type 2 diabetes patients is associated with poor prognosis and treatment results. Major depression and concurrent sleep disorders have been related to disturbances of the biological clock. The biological clock is also involved in regulation of glucose metabolism by modulating peripheral insulin sensitivity. Light therapy has been shown to be an effective antidepressant that 'resets' the biological clock...
July 24, 2015: BMC Psychiatry
https://www.readbyqxmd.com/read/25851098/depression-in-type-2-diabetes-mellitus-prevalence-impact-and-treatment
#15
REVIEW
Katherine Semenkovich, Miriam E Brown, Dragan M Svrakic, Patrick J Lustman
Clinically significant depression is present in one of every four people with type 2 diabetes mellitus (T2DM). Depression increases the risk of the development of T2DM and the subsequent risks of hyperglycemia, insulin resistance, and micro- and macrovascular complications. Conversely, a diagnosis of T2DM increases the risk of incident depression and can contribute to a more severe course of depression. This linkage reflects a shared etiology consisting of complex bidirectional interactions among multiple variables, a process that may include autonomic and neurohormonal dysregulation, weight gain, inflammation, and hippocampal structural alterations...
April 2015: Drugs
https://www.readbyqxmd.com/read/25791519/obese-insulin-resistance-accelerates-and-aggravates-cardiometabolic-disorders-and-cardiac-mitochondrial-dysfunction-in-estrogen-deprived-female-rats
#16
Sivaporn Sivasinprasasn, Piangkwan Sa-Nguanmoo, Wasana Pratchayasakul, Sirinart Kumfu, Siriporn C Chattipakorn, Nipon Chattipakorn
Women have a lower incidence of cardiovascular diseases (CVD) than men at a similar age but have an increased incidence of CVD and metabolic syndrome after menopause, indicating the possible protective effects of estrogen on cardiometabolic function. Although obesity is known to increase CVD risks, its impact on the heart on estrogen deprivation is still inconclusive. We investigated the effects of obese-insulin resistance on cardiometabolic function in estrogen-deprived ovariectomized rats. Adult female ovariectomized (O) or sham (S)-operated rats randomly received either normal diet (ND, 19...
2015: Age (2005-)
https://www.readbyqxmd.com/read/25675988/a-comprehensive-review-of-metabolic-syndrome-affecting-erectile-dysfunction
#17
REVIEW
Ecem Kaya, Suresh C Sikka, Serap Gur
INTRODUCTION: Metabolic syndrome (MetS) is the most important public health issue threatening the health of men and women all over the world. Its current prevalence (i.e., approximately 30%) is continuously increasing. MetS by itself is considered a risk factor for erectile dysfunction (ED). AIM: To focus on the definition epidemiology, pathogenesis, and possible mechanistic links between MetS and ED in order to provide guidelines for treating such individuals. METHODS: The search strategies yielded total records screened from PubMed...
April 2015: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/25474313/the-effects-of-lifestyle-interventions-on-long-term-weight-management-cardiometabolic-risk-and-depressive-symptoms-in-people-with-psychotic-disorders-a-meta-analysis
#18
Jojanneke Bruins, Frederike Jörg, Richard Bruggeman, Cees Slooff, Eva Corpeleijn, Marieke Pijnenborg
AIMS: The aim of this study was to estimate the effects of lifestyle interventions on bodyweight and other cardiometabolic risk factors in people with psychotic disorders. Additionally, the long-term effects on body weight and the effects on depressive symptoms were examined. MATERIAL AND METHODS: We searched four databases for randomized controlled trials (RCTs) that compared lifestyle interventions to control conditions in patients with psychotic disorders. Lifestyle interventions were aimed at weight loss or weight gain prevention, and the study outcomes included bodyweight or metabolic parameters...
2014: PloS One
https://www.readbyqxmd.com/read/25236943/adolescents-with-severe-obesity-outcomes-of-participation-in-an-intensive-obesity-management-programme
#19
COMPARATIVE STUDY
P Luca, E Dettmer, M Khoury, P Grewal, C Manlhiot, B W McCrindle, C S Birken, J K Hamilton
BACKGROUND: Most interventions for childhood obesity are randomized controlled studies. Less is known about the effectiveness of clinical obesity programmes. OBJECTIVE: To assess outcomes in adolescents participating in the SickKids Team Obesity Management Program (STOMP) vs. a comparison group of obese adolescents. METHODS: Severely obese adolescents (n = 75) in STOMP (15.1 ± 1.8 years, body mass index [BMI] 44.8 ± 7.8 kg m(-2) ) were compared with adolescents (n = 41) not in the programme (14...
August 2015: Pediatric Obesity
https://www.readbyqxmd.com/read/25035574/sleep-behaviors-and-parent-functioning-in-young-children-with-type-1-diabetes
#20
Maureen Monaghan, Linda J Herbert, Fran R Cogen, Randi Streisand
This study evaluates sleep characteristics among young children with type 1 diabetes and associations with parent sleep and emotional functioning and diabetes care. Study participants included twenty-four parents of young children with type 1 diabetes (ages 2-5) enrolled in a pilot study of a randomized-controlled trial. Child sleep characteristics were within normal limits. However, increased child bedtime resistance and behavioral insomnia were related to greater parent stress, anxiety, and depression and use of an intensive insulin regimen...
January 1, 2012: Children's Health Care: Journal of the Association for the Care of Children's Health
keyword
keyword
110499
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"