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insulin resistance depression randomized

Hiroyuki Umegaki, Taeko Makino, Kazuki Uemura, Hiroyuki Shimada, Xian W Cheng, Masafumi Kuzuya
AIM: Physical activity (PA) and cognition have reportedly been associated with each other. However, it remains to be elucidated what intensities of PA are most strongly associated with cognition. In the current study, we aimed to determine the association between the intensities of objectively measured PA and cognitive function. METHODS: The present study was a cross-sectional analysis of the data obtained at registration in a randomized control trial in Toyota, Japan...
February 28, 2018: Geriatrics & Gerontology International
Dorte Glintborg, Magda Lambaa Altinok, Pernille Ravn, Kurt B Stage, Kurt Højlund, Marianne Andersen
BACKGROUND/AIMS: Polycystic ovary syndrome (PCOS) is associated with insulin resistance, adrenal hyperactivity and decreased mental health. We aimed to investigate changes in adrenal activity, metabolic status, and mental health in PCOS during treatment with escitalopram or placebo. METHODS: Forty-two overweight premenopausal women with PCOS and no clinical depression were randomized to 12-weeks SSRI (20 mg escitalopram/day, n=21) or placebo (n=21). Patients underwent clinical examination, fasting blood samples, adrenocorticotroph hormone (ACTH) test, 3 hours oral glucose tolerance test (OGTT) and filled in questionnaires regarding mental health and health related quality of life (HRQoL): WHO Well Being Index (WHO-5), Major Depression Inventory (MDI), Short Form 36 (SF-36), and PCOS questionnaire...
February 22, 2018: Endocrine Connections
Fariba Raygan, Vahidreza Ostadmohammadi, Fereshteh Bahmani, Zatollah Asemi
BACKGROUND: This study was carried out to evaluate the effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in diabetic people with coronary heart disease (CHD). METHODS: This randomized, double-blind, placebo-controlled trial was carried out among 60 diabetic people with CHD, aged 45-85 years old. Subjects were randomly allocated into two groups to receive either 50,000 IU vitamin D every 2 weeks plus 8 × 10 9 CFU/g probiotic of Lactocare Zisttakhmir Co (n = 30) or placebo (n = 30) for 12 weeks...
February 9, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
John S Mulvahill, Ginger E Nicol, David Dixon, Eric J Lenze, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger, Benoit H Mulsant
BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression. DESIGN: Secondary analysis of a randomized controlled trial...
December 2017: Journal of the American Geriatrics Society
Atefe Ghahremanloo, Reza Hajipour, Mina Hemmati, Maryam Moossavi, Zabihullah Mohaqiq
Background Prevention and treatment of obesity is a way to reduce cardiovascular disease, diabetes and depression. Pumpkin as a favorable plant has different properties notably antioxidant, lipid-lowering and anti-diabetic potential. The aim of this study was to assess the anti-obesity effects of pumpkin in diet-induced obese rats. Methods Thirty adult male Wistar rats were randomly divided into five groups (n=6) of healthy control, dietary fatty control rats, and three experimental dietary fatty rats that received hydro-alcoholic extract of pumpkin once daily at doses 100 and 200 and 400 mg/kg, respectively...
October 24, 2017: Journal of Complementary & Integrative Medicine
Amir Ghaderi, Hamid Reza Banafshe, Maryam Motmaen, Morad Rasouli-Azad, Fereshteh Bahmani, Zatollah Asemi
BACKGROUND: Vitamin D deficiency may be associated with some complications including nonspecific musculoskeletal pain and periodontal disease in maintenance methadone treatment (MMT) patients. This study was designed to determine the effect of vitamin D supplementation on psychological symptoms and metabolic profiles in MMT patients. METHODS: This randomized, double-blind, placebo-controlled, clinical trial was carried out among 68 MMT patients. Participants were randomly allocated to receive either 50,000IU vitamin D supplements (n=34) or placebo (n=34) every 2weeks for 12weeks...
October 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
Lauren B Shomaker, Stephanie Bruggink, Bernadette Pivarunas, Amanda Skoranski, Jillian Foss, Ella Chaffin, Stephanie Dalager, Shelly Annameier, Jordan Quaglia, Kirk Warren Brown, Patricia Broderick, Christopher Bell
OBJECTIVE: (1) Evaluate feasibility and acceptability of a mindfulness-based group in adolescent girls at-risk for type 2 diabetes (T2D) with depressive symptoms, and (2) compare efficacy of a mindfulness-based versus cognitive-behavioral group for decreasing depressive symptoms and improving insulin resistance. DESIGN AND SETTING: Parallel-group, randomized controlled pilot trial conducted at a university. PARTICIPANTS: Thirty-three girls 12-17y with overweight/obesity, family history of diabetes, and elevated depressive symptoms were randomized to a six-week mindfulness-based (n=17) or cognitive-behavioral program (n=16)...
June 2017: Complementary Therapies in Medicine
Wannipa Tunapong, Nattayaporn Apaijai, Sakawdaurn Yasom, Pongpan Tanajak, Keerati Wanchai, Titikorn Chunchai, Sasiwan Kerdphoo, Sathima Eaimworawuthikul, Parameth Thiennimitr, Anchalee Pongchaidecha, Anusorn Lungkaphin, Wasana Pratchayasakul, Siriporn C Chattipakorn, Nipon Chattipakorn
PURPOSE: In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardioprotection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. However, the effects of prebiotics such as xylooligosaccharides (XOS); probiotics such as Lactobacillus paracasei STII01 HP4, and synbiotics on metabolic and LV function in obese insulin-resistant rats have not been investigated...
June 12, 2017: European Journal of Nutrition
Anne Katrine Pagsberg, Pia Jeppesen, Dea Gowers Klauber, Karsten Gjessing Jensen, Ditte Rudå, Marie Stentebjerg-Olesen, Peter Jantzen, Simone Rasmussen, Eva Ann-Sofie Saldeen, Maj-Britt Glenn Lauritsen, Niels Bilenberg, Anne Dorte Stenstrøm, Louise Nyvang, Sarah Madsen, Thomas M Werge, Theis Lange, Christian Gluud, Maria Skoog, Per Winkel, Jens Richardt M Jepsen, Birgitte Fagerlund, Christoph U Correll, Anders Fink-Jensen
BACKGROUND: Head-to-head trials to guide antipsychotic treatment choices for paediatric psychosis are urgently needed because extrapolations from adult studies might not be implementable. In this superiority trial with two-sided significance testing, we aimed to compare the efficacy and safety of quetiapine-extended release (quetiapine-ER) versus aripiprazole in children and adolescents with first-episode psychosis, to determine whether differences between the two treatments were sufficient to guide clinicians in their choice of one drug over the other...
August 2017: Lancet Psychiatry
Lauren B Shomaker, Nichole R Kelly, Rachel M Radin, Omni L Cassidy, Lisa M Shank, Sheila M Brady, Andrew P Demidowich, Cara H Olsen, Kong Y Chen, Eric Stice, Marian Tanofsky-Kraff, Jack A Yanovski
BACKGROUND: Depression is associated with poor insulin sensitivity. We evaluated the long-term effects of a cognitive behavioral therapy (CBT) program for prevention of depression on insulin sensitivity in adolescents at risk for type 2 diabetes (T2D) with depressive symptoms. METHODS: One-hundred nineteen adolescent females with overweight/obesity, T2D family history, and mild-to-moderate depressive symptoms were randomized to a 6-week CBT group (n = 61) or 6-week health education (HE) control group (n = 58)...
October 2017: Depression and Anxiety
Laura G Cooney, Iris Lee, Mary D Sammel, Anuja Dokras
STUDY QUESTION: Do women with polycystic ovary syndrome (PCOS) have an increased prevalence of moderate and severe depressive and anxiety symptoms compared with control women, and do these symptoms correlate with age, BMI, testosterone, hirsutism or insulin resistance (IR)? SUMMARY ANSWER: Women with PCOS have significantly increased odds of moderate and severe depressive and anxiety symptoms, independent of obesity, and the symptoms are weakly associated with age, BMI, elevated testosterone, hirsutism and IR...
May 1, 2017: Human Reproduction
Emma Del Carmen Macías-Cortés, Lidia Llanes-González, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil
BACKGROUND: Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that metabolic dysregulation may predict poor response to conventional antidepressants. Response to depression treatment has not been studied in homeopathic medicine. The aim of this study was to investigate the prevalence of metabolic disorders in depressed climacteric women treated with homeopathic medicines, fluoxetine or placebo, and if these alterations have any association with response to depression treatment...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
Danielle S Cha, Michael W Best, Christopher R Bowie, Laura Ashley Gallaugher, Hanna O Woldeyohannes, Joanna K Soczynska, Gary Lewis, Glenda MacQueen, Barbara J Sahakian, Sidney H Kennedy, Jane P Lui, Rodrigo B Mansur, Roger S McIntyre
BACKGROUND: Cognitive dysfunction in major depressive disorder (MDD) is identified as a primary therapeutic target; no current treatment is approved for the treatment of cognitive dysfunction in MDD. We examined whether intranasal insulin offered a beneficial effect across measures of cognitive function in adults with MDD. METHODS: Thirty-five adults (18-65 years of age: 47.09±9.89) meeting criteria for a major depressive episode as per the Diagnostic and Statistical Manual (DSM)-IV-Treatment Revised were included in this randomized, double blind, placebo-controlled, crossover design study...
March 1, 2017: Journal of Affective Disorders
R Colle, D de Larminat, S Rotenberg, F Hozer, P Hardy, C Verstuyft, B Fève, E Corruble
Introduction: Selective agonists of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-γ) are used for the treatment of type 2 diabetes. We reviewed their efficacy and safety for the treatment of major depression and the association of their potential antidepressant effects with changes in biomarkers of metabolism and inflammation. Methods: From 8 studies, 4 open-label trials, and 4 randomized controlled trials (RCT) (3 vs. placebo and 1 vs. metformin), 448 patients with major depression were included, of which 209 patients received PPAR-γ agonists (pioglitazone or rosiglitazone) for 6-12 weeks, either alone or in add-on therapy to conventional treatments...
March 2017: Pharmacopsychiatry
Ebrahim Kouchaki, Omid Reza Tamtaji, Mahmoud Salami, Fereshteh Bahmani, Reza Daneshvar Kakhaki, Elmira Akbari, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Zatollah Asemi
BACKGROUND & AIMS: This trial was performed to evaluate the effects of probiotic intake on disability, mental health and metabolic condition in subjects with multiple sclerosis (MS). METHODS: This randomized double-blind placebo-controlled clinical trial was conducted among 60 MS patients. Participants were randomly allocated into two groups to receive either a probiotic capsule (n = 30) or placebo containing starch (n = 30) for 12 weeks. Expanded disability status scale (EDSS) scoring and parameters of mental health were recorded at the baseline and 12 weeks after the intervention...
October 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Lauren B Shomaker, Nichole R Kelly, Courtney K Pickworth, Omni L Cassidy, Rachel M Radin, Lisa M Shank, Anna Vannucci, Katherine A Thompson, Sara A Armaiz-Flores, Sheila M Brady, Andrew P Demidowich, Ovidiu A Galescu, Amber B Courville, Cara Olsen, Kong Y Chen, Eric Stice, Marian Tanofsky-Kraff, Jack A Yanovski
BACKGROUND: Prospective data suggest depressive symptoms worsen insulin resistance and accelerate type 2 diabetes (T2D) onset. PURPOSE: We sought to determine whether reducing depressive symptoms in overweight/obese adolescents at risk for T2D would increase insulin sensitivity and mitigate T2D risk. METHOD: We conducted a parallel-group, randomized controlled trial comparing a 6-week cognitive-behavioral (CB) depression prevention group with a 6-week health education (HE) control group in 119 overweight/obese adolescent girls with mild-to-moderate depressive symptoms (Center for Epidemiological Studies-Depression Scale [CES-D] ≥16) and T2D family history...
October 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Wanpitak Pongkan, Hiranya Pintana, Sivaporn Sivasinprasasn, Thidarat Jaiwongkam, Siriporn C Chattipakorn, Nipon Chattipakorn
Low testosterone level is associated with increased risks of cardiovascular diseases. As obese-insulin-resistant condition could impair cardiac function and that the incidence of obesity is increased in aging men, a condition of testosterone deprivation could aggravate the cardiac dysfunction in obese-insulin-resistant subjects. However, the mechanism underlying this adverse effect is unclear. This study investigated the effects of obesity on metabolic parameters, heart rate variability (HRV), left ventricular (LV) function, and cardiac mitochondrial function in testosterone-deprived rats...
June 2016: Journal of Endocrinology
Marnie G Silverstein-Metzler, Carol A Shively, Thomas B Clarkson, Susan E Appt, J Jeffrey Carr, Stephen B Kritchevsky, Sara R Jones, Thomas C Register
Selective serotonin reuptake inhibitor (SSRI) antidepressants are widely prescribed for depression and other disorders. SSRIs have become one of the most commonly used drugs in the United States, particularly by women. Acute effects on body composition and carbohydrate metabolism have been reported, but little is known regarding the effects of chronic SSRI use. We evaluated the effects of chronic administration of a commonly prescribed SSRI, sertraline HCl, on body weight and composition, fat distribution, carbohydrate metabolism, as well as activity, in adult female depressed and nondepressed cynomolgus monkeys (Macaca fascicularis; n=42) using a placebo-controlled, longitudinal, randomized study design...
June 2016: Psychoneuroendocrinology
Jeffrey Rado, Stephanie von Ammon Cavanaugh
OBJECTIVE: This 24-week pilot study assessed the efficacy, tolerability, and safety of adjunctive metformin versus placebo for the prevention of olanzapine-associated weight gain in community-dwelling adult patients with schizophrenia, schizoaffective disorder, bipolar disorder, or major depression with psychotic features. METHODS: In a double-blind study, 25 patients were randomly assigned to receive 24 weeks of either olanzapine plus metformin or olanzapine plus placebo...
April 2016: Journal of Clinical Psychopharmacology
Ghodarz Akkasheh, Zahra Kashani-Poor, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Hossein Akbari, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi, Ahmad Esmaillzadeh
OBJECTIVE: We are aware of no study examining the effects of probiotic supplementation on symptoms of depression, metabolic profiles, serum high-sensitivity C-reactive protein (hs-CRP), and biomarkers of oxidative stress in patients with major depressive disorder (MDD). The present study was designed to determine the effects of probiotic intake on symptoms of depression and metabolic status in patients with MDD. METHODS: This randomized, double-blind, placebo-controlled clinical trial included 40 patients with a diagnosis of MDD based on DSM-IV criteria whose age ranged between 20 and 55 y...
March 2016: Nutrition
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