Bart J van Essen, Ganash N Tharshana, Wouter Ouwerkerk, Poh Suan Daniel Yeo, David Sim, Fazlur Jaufeerally, Hean Yee Ong, Lieng Hsi Ling, Dinna Kar Nee Soon, Shao Guang Sheldon Lee, Gerard Leong, Seet Yoong Loh, Ru San Tan, Chrishan J Ramachandra, Derek J Hausenloy, Oi Wai Liew, Jenny Chong, Adriaan A Voors, Carolyn S P Lam, A Mark Richards, Jasper Tromp
AIM: Pathophysiological differences between patients with heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction (EF) remain unclear. Therefore we used a phenomics approach, integrating selected proteomics data with patient characteristics and cardiac structural and functional parameters, to get insight into differential pathophysiological mechanisms and identify potential treatment targets. METHODS AND RESULTS: We report data from a representative subcohort of the prospective Singapore Heart Failure Outcomes and Phenotypes (SHOP), including patients with HFrEF (EF <40%, n = 217), HFpEF (EF ≥50%, n = 213), and age- and sex-matched controls without HF (n = 216)...
February 4, 2024: European Journal of Heart Failure