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https://www.readbyqxmd.com/read/29996001/the-chemical-compositions-of-angelica-pubescens-oil-and-its-prevention-of-uv-b-radiation-induced-cutaneous-photoaging
#1
Dingkang Chen, Zhiyun Du, Zhirong Lin, Ping Su, Hanyi Huang, Zhirong Ou, Wanyi Pan, Shiya Huang, Kun Zhang, Xi Zheng, Li Lin, Lanyue Zhang
Angelica pubescens, a plant of the family Umbelliferae, has been widely used as traditional Chinese medicine for the treatment of many diseases; however, there has been minimal modern research focused on the pharmacological activity of oils extracted from Angelica pubescens, in particular, the potential anti-photoaging effects. Therefore, in the present study, we analyzed the chemical composition of Angelica pubescens oil (AO) and evaluated its bioactivity against photoaging in ultraviolet (UV) -B radiation-induced hairless mice...
July 11, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29989651/osthole-enhances-antitumor-activity-and-irradiation-sensitivity-of-cervical-cancer-cells-by-suppressing-atm-nf%C3%A2-%C3%AE%C2%BAb-signaling
#2
Yilin Che, Juan Li, Zongjuan Li, Jing Li, Shuai Wang, Ying Yan, Kun Zou, Lijuan Zou
Osthole (7‑methoxy‑8‑isopentenoxycoumarin) is an O‑methylated coumarin, originally extracted from Chinese herbal medicine. It has been demonstrated that osthole has antitumor effects in various cancer cells in vitro. The present study assessed the effects of osthole on the regulation of cervical cancer cell viability, apoptosis, and radiation sensitization. HeLa, SiHa, C‑33A and CaSki cervical cancer cell lines were cultured and treated with osthole and/or irradiation and then subjected to 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑-diphenyl‑tetrazolium bromide cell viability, colony formation, apoptosis, acridine orange/ethidium bromide fluorescence staining, wound‑healing, Transwell migration and invasion, immunofluorescence, Comet and western blot assays...
June 20, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29989446/osthole-delays-tert-butyl-hydroperoxide-induced-premature-senescence-in-neural-stem-cells
#3
Yingjia Yao, Xicai Liang, Yue Shi, Ying Lin, Jingxian Yang
In our previous study, we found that osthole could promote the ability of proliferation and differentiation in normal neural stem cells (NSCs) under normal condition. Then, we used tert-butyl hydroperoxide (t-BHP) to establish the model of senescence NSCs to detect the effects of osthole. Interestingly, the immunofluorescence results showed that osthole (100 μM) could enhance the ability of proliferation and differentiation, and CCK-8 assay results showed that osthole could also enhance the cell viabilities...
July 10, 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29959744/application-of-metabolomics-in-the-study-of-natural-products
#4
Qi Zhao, Jia-Le Zhang, Fei Li
LC-MS-based metabolomics could have a major impact in the study of natural products, especially in its metabolism, toxicity and activity. This review highlights recent applications of metabolomics approach in the study of metabolites and toxicity of natural products, and the understanding of their effects on various diseases. Metabolomics has been employed to study the in vitro and in vivo metabolism of natural compounds, such as osthole, dehydrodiisoeugenol, and myrislignan. The pharmacological effects of natural compounds and extracts were determined using metabolomics technology combined with diseases models in animal, including osthole and nutmeg extracts...
June 29, 2018: Natural Products and Bioprospecting
https://www.readbyqxmd.com/read/29944638/the-naturally-derived-small-compound-osthole-inhibits-osteoclastogenesis-to-prevent-ovariectomy-induced-bone-loss-in-mice
#5
Dongfeng Zhao, Qiang Wang, Yongjian Zhao, Hao Zhang, Nannan Sha, Dezhi Tang, Shufen Liu, Sheng Lu, Qi Shi, Yan Zhang, Yufeng Dong, Yongjun Wang, Bing Shu
OBJECTIVE: This study was to determine the bone protective effects and underlying mechanisms of Osthole (OT) in ovariectomized (OVX) mice. We found that the inhibitory effects of OT on receptor activator of nuclear factor kappa-B ligand (RANKL)-activated osteoclastogenesis are responsible for its bone protective effects in OVX mice. METHODS: Eight-week-old mice were ovariectomized and OT (10 mg/kg/d) was intraperitoneally administrated to OVX mice 7 days after the surgery and were sacrificed at the end of the 3 months...
June 25, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29923687/permeation-enhancing-effects-and-mechanisms-of-borneol-and-menthol-on-ligustrazine-a-multiscale-study-using-in-vitro-and-coarse-grained-molecular-dynamics-simulation-methods
#6
Xingxing Dai, Ran Wang, Zhimin Wu, Shujuan Guo, Chang Yang, Lina Ma, Liping Chen, Xinyuan Shi, Yanjiang Qiao
Borneol (BO) and menthol (MEN) are two widely used natural permeation enhancers in the transdermal drug delivery system. In previous studies, their permeation enhancement effects and mechanisms of action on the hydrophobic drug osthole (logP=3.8) and hydrophilic drug 5-fluorouracil (logP=-0.9) have been studied. In this study, ligustrazine (LTZ), whose logP is 1.3, was used as a model drug to provide a comprehensive understanding of the influence of its logP on the permeation-enhancing effects of BO and MEN...
June 20, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29860992/osthole-decreases-collagen-i-iii-contents-and-their-ratio-in-tgf-%C3%AE-1-overexpressed-mouse-cardiac-fibroblasts-through-regulating-the-tgf-%C3%AE-smad-signaling-pathway
#7
Jin-Cheng Liu, Lei Zhou, Feng Wang, Zong-Qi Cheng, Chen Rong
The present study was designed to elucidate whether the mechanism by which osthole decreases collagenI/III contents and their ratio is regulating the TGF-β/Smad signaling pathway in TGF-β1-overexpressed mouse cardiac fibroblasts (CFs). These CFs were cultured and treated with different concentrations of osthole. Our results showed that the TGF-β1 expression in the CFs transfected with that the recombinant expression plasmids pcDNA3.1(+)-TGF-β1 was significantly enhanced. After the CFs were treated with 1...
May 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29845504/preparation-and-pharmacokinetics-evaluation-of-solid-self-microemulsifying-drug-delivery-system-s-smedds-of-osthole
#8
Chaojie Sun, Yun Gui, Rongfeng Hu, Jiayi Chen, Bin Wang, Yuxing Guo, Wenjie Lu, Xiangjiang Nie, Qiang Shen, Song Gao, Wenyou Fang
The study was performed aiming to enhance the solubility and oral bioavailability of poorly water-soluble drug osthole by formulating solid self-microemulsifying drug delivery system (S-SMEDDS) via spherical crystallization technique. Firstly, the liquid self-microemulsifying drug delivery system (L-SMEDDS) of osthole was formulated with castor oil, Cremophor RH40, and 1,2-propylene glycol after screening various lipids and emulsifiers. The type and amount of polymeric materials, good solvents, bridging agents, and poor solvents in S-SMEDDS formulations were further determined by single-factor study...
July 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29803570/comparative-pharmacokinetics-of-six-coumarins-in-normal-and-breast-cancer-bone-metastatic-mice-after-oral-administration-of-wenshen-zhuanggu-formula
#9
Weiling Chen, Jiajia Li, Zhenping Sun, Chunyu Wu, Jiao Ma, Jianyi Wang, Sheng Liu, Xianghui Han
ETHNOPHARMACOLOGICAL RELEVANCE: Wenshen Zhuanggu Formula (WSZG) is a traditional Chinese medicine (TCM) prescription used in clinics for adjuvant treatment of breast cancer bone metastases in Longhua Hospital in China. WSZG has been reported to decrease the risk of bone metastases and alleviate the severity of bone lesions in a breast cancer xenograft model. AIM OF THE STUDY: The present study aimed at investigating the pharmacokinetic behaviors of six coumarins in normal and breast cancer bone-metastatic mice following oral administration of WSZG extract...
May 24, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29750855/pharmacological-and-nutritional-effects-of-natural-coumarins-and-their-structure-activity-relationships
#10
REVIEW
Jing-Jing Zhu, Jian-Guo Jiang
Coumarins are fused benzene and pyrone ring systems with a wide spectrum of bioactivities, including antitumor, anti-inflammation, antiviral, and antibacterial effects. In this paper, the current development of coumarin-based drugs is introduced, and their structure-activity relationship is discussed by reviewing the relevant literature published in the past 20 years. Coumarin molecules can be customized by the target site to prevent systemic side effects by virtue of structural modification. The ortho-phenolic hydroxyl on the benzene ring has remarkable antioxidant and antitumor activities...
May 11, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29743895/osthole-improves-collagen-induced-arthritis-in-a-rat-model-through-inhibiting-inflammation-and-cellular-stress
#11
Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang, Ming Yang
Background: Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored. In the present study, a collagen-induced arthritis rat model, IL-1β-stimulated SW982 cells, and RA-like fibroblast-like synoviocytes (FLS) were employed to investigate the effect and possible mechanism of osthole on arthritis in vivo and in vitro. Results: 20 and 40 mg/kg osthole significantly alleviated collagen-induced arthritic symptoms based on histopathology and clinical arthritis scores, and improved erosion using HE staining...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29741958/clinical-assessment-and-patient-reported-outcome-measures-in-low-back-pain-a-survey-among-primary-health-care-physiotherapists
#12
Sara Östhols, Carina Boström, Eva Rasmussen-Barr
PURPOSE: We aimed to map the physiotherapy practice in Sweden of clinical tests and patient-reported outcome measures in low-back pain (LBP), and to study advantages and barriers in using patient-reported outcome measures. METHODS: An online survey was mailed to 4934 physiotherapists in primary health care in Sweden. Multiple choice questions investigated the use of clinical tests and patient-reported outcome measures in assessing patients with LBP. Open questions investigating the advantages and barriers to the use of patient-reported outcome measures were analyzed with content analysis...
May 9, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29736690/osthole-ameliorates-neurogenic-and-inflammatory-hyperalgesia-by-modulation-of-inos-cox-2-and-inflammatory-cytokines-in-mice
#13
Gurjit Singh, Rajbir Bhatti, Rahul Mannan, Drishtant Singh, Anup Kesavan, Palwinder Singh
BACKGROUND: Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50 ), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are yet to be determined. METHODS: The animals (mice) were assessed for general behaviour and mortality in varying doses (50, 300, and 2000 mg kg-1 ) of osthole for acute toxicity over 14 days...
May 7, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29736204/osthole-attenuates-myocardial-ischemia-reperfusion-injury-in-rats-by-inhibiting-apoptosis-and-inflammation
#14
Jingguo Wu, Yang Yang, Nan Xun, Lijin Zeng, Zhenyu Li, Wen Yang, Yanbing Liang, Zhongfu Ma, Hao Tang
This study was performed to evaluate the cardioprotective effects of osthole (OST) in a rat model of myocardial ischemia/reperfusion injury (MI/RI) and the underlying mechanism. We exposed rat hearts to left anterior descending coronary artery ligation for 30 min followed by 24 h of reperfusion. The results showed that pretreatment with OST ameliorated MI/RI as evidenced by histopathological examination. Moreover, the terminal deoxynucleotidyl transferase dUTP nick end-labeling assay demonstrated that OST suppressed myocardial apoptosis, which may be related to an increase in the Bcl-2/Bax ratio and inhibition of caspase-3 and caspase-9 activation...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29724067/exploration-of-the-fluorescent-properties-and-the-modulated-activities-against-sirtuin-fluorogenic-assays-of-chromenone-derived-natural-products
#15
Hui Wen, Nina Xue, Feng Wu, Yujun He, Gang Zhang, Zebin Hu, Huaqing Cui
Chromenone-derived natural products include chromones (flavone, isoflavone) and coumarins. Chromenone compounds not only exhibit impressive biological activities, but also are an important resource of experimentally used fluorophores, such as, 7-amino-4-methylcoumarin (AMC). Various chromenone compounds have reported to have weak fluorescence, and this has the potential to interfere with the measurements during AMC fluorogenic assays and result in non-robust assay readouts. Several flavones and isoflavones were found as SIRT1 activators, while fluorogenic sirtuin assays utilized AMC labelled peptides as the substrates...
May 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29713525/efficacy-of-osthole-in-management-of-hypoperfused-retina
#16
Ran Du, Zhao-Yang Meng, Jia-Lin Wang, Yan-Ling Wang
Purpose: To determine the effect of osthole on the retina in a chronic cerebral hypoperfusion (CCH) rat model and to investigate its therapeutic activity. Methods: Seventy-two rats were randomly allocated into 6 groups. CCH was induced by permanent bilateral common carotid artery occlusion (BCCAO) in five groups. Sham surgery was performed without occlusion of the artery in the sixth group (control group). Animals were administered with saline (model group), osthole (osthole-IG group), aspirin (aspirin group), or ginaton (ginaton group); the osthole-PI group was performed with peribulbar injection of osthole...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29615702/global-proteomics-deciphered-novel-function-of-osthole-against-pulmonary-arterial-hypertension
#17
Li Yao, Yuxia Yang, Guanhong He, Chunqing Ou, Lan Wang, Kaixuan Liu
Pulmonary arterial hypertension (PAH) is a progressive cardiovascular-disease with high mortality lacking high-efficiency drug. Our efforts attempted to delineate therapeutic action of osthole produced by Angelica Pubescens Maxim, which has the capacity to treat PAH by exploiting an iTRAQ-based proteomic method. Excitingly, osthole was observed to significantly restore 98 of 315 differential proteins significantly modified by PAH progression. They were primarily annotated into 24 signaling pathways. Four mostly affected proteins (RPL15, Cathepsin S, Histone H3...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29590128/osthole-inhibits-gastric-cancer-cell-proliferation-through-regulation-of-pi3k-akt
#18
Xiaojun Xu, Xiaoyuan Liu, Yan Zhang
Osthole is an active compound isolated from Chinese herb Cnidium monnieri (L.) Cusson, and had been reported to possess antitumor effect. However, the effect of osthole on the gastric cancer cells has not been investigated. In this study, the effects of osthole on the proliferation of human gastric cancer cells were tested. The data showed that osthole treatment significantly inhibited the proliferation of gastric cancer cells and resulted in the cell cycle arrest at G2/M phase in a dose-dependent manner. Western-blot study showed that the expression of cyclin B1 and cdc2 was markedly reduced by osthole...
2018: PloS One
https://www.readbyqxmd.com/read/29587226/comparative-metabolites-profiles-of-osthole-in-normal-and-osteoporosis-rats-using-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#19
Nani Wang, Xuping Wang, Yang Zhang, Qiaoyan Zhang, Pingcui Xu, Hailiang Xin, Renjie Wu, Dan Shou, Luping Qin
Osthole is a derivative of coumnarin, which has been used to treat several diseases, including osteoporosis. To investigate the metabolite profile of osthole in osteoporosis rats was utilized to understand its underlying mechanisms of its anti-osteoporosis effect. In this study, plasma samples were collected from normal and osteoporosis rats after oral administration of osthole and analyzed to identify the metabolites of osthole by high performance liquid chromatography quadrupole time-of-flight mass spectrometry...
May 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29579711/osthole-inhibits-the-pi3k-akt-signaling-pathway-via-activation-of-pten-and-induces-cell-cycle-arrest-and-apoptosis-in-esophageal-squamous-cell-carcinoma
#20
Xinbing Zhu, Zhengzheng Li, Tongtong Li, Fei Long, Yuesheng Lv, Lei Liu, Xuefeng Liu, Qimin Zhan
Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors and is known to be lack of effective therapy. Thus, novel therapeutic strategies are greatly needed for treatment of ESCC. Osthole, a natural active extract, has been documented to have anti-tumor activity. However, the effect of osthole on ESCC cells has not been elucidated. In this study, we demonstrated that osthole could inhibit the ESCC cell proliferation in dose- and time-dependent manner. Osthole treatment also induced G2/M phase arrest and apoptosis of ESCC cells...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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