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Osthole

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https://www.readbyqxmd.com/read/29319219/osthole-induces-human-nasopharyngeal-cancer-cells-apoptosis-through-fas-fas-ligand-and-mitochondrial-pathway
#1
Pei-Ying Liu, Dun-Cheng Chang, Yu-Sheng Lo, Yi-Ting Hsi, Chia-Chieh Lin, Yi-Ching Chuang, Shu-Hui Lin, Ming-Ju Hsieh, Mu-Kuan Chen
Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia. The present study investigated the activity of osthole in suppressing NPC along with the underlying mechanism. Cell growth inhibition was measured using the MTT assay. Apoptosis was detected through 4',6-diamidino-2-phenylindole staining and flow cytometry. Western blotting was used to identify the signaling pathway. Osthole markedly inhibited cell proliferation and induced apoptosis in the NPC cell line. Western blotting results revealed the increased activation of caspases 3, 8, and 9 and poly (ADP-ribose) polymerase...
January 10, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29301373/potential-anticancer-properties-of-osthol-a-comprehensive-mechanistic-review
#2
REVIEW
Yalda Shokoohinia, Fataneh Jafari, Zeynab Mohammadi, Leili Bazvandi, Leila Hosseinzadeh, Nicholas Chow, Piyali Bhattacharyya, Mohammad Hosein Farzaei, Ammad Ahmad Farooqi, Seyed Mohammad Nabavi, Mükerrem Betül Yerer, Anupam Bishayee
Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin isolated from Apiaceaous plants which has demonstrated several pharmacological effects, such as antineoplastic, anti-inflammatory and antioxidant properties...
January 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29277774/combination-of-osthole-and-cisplatin-against-rhabdomyosarcoma-te671-cells-yielded-additive-pharmacologic-interaction-by-means-of-isobolographic-analysis
#3
Agata Jarząb, Jarogniew Łuszczki, Małgorzata Guz, Krystyna Skalicka-Woźniak, Marta Hałasa, Jolanta Smok-Kalwat, Krzysztof Polberg, Andrzej Stepulak
BACKGROUND/AIM: Osthole is a simple coumarin that has been found to have anticancer, anti-inflammatory, antiviral, anticoagulant, anticonvulsant and antiallergic activities. The aim of this study was to analyze the combined anti-proliferative effect of cisplatin (CDDP) and osthole on a rhabdomyosarcoma cell line, and assess the pharmacology of drug-drug interaction between these drugs using isobolographic analysis. MATERIALS AND METHODS: The anticancer actions of osthole in combination with CDDP were evaluated using the tetrazolium dye-based MTT cell proliferation assay...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29233045/the-%C3%AE-amylase-and-%C3%AE-glucosidase-inhibitory-activities-of-the-dichloromethane-extracts-and-constituents-of-ferulago-bracteata-roots
#4
Songül Karakaya, Sefa Gözcü, Zühal Güvenalp, Hilal Özbek, Hafize Yuca, Benan Dursunoğlu, Cavit Kazaz, Ceyda Sibel Kılıç
CONTEXT: Ferulago (Apiaceae) species have been used since ancient times for the treatment of intestinal worms, hemorrhoids, and as a tonic, digestive, aphrodisiac, or sedative, as well as in salads or as a spice due to their special odors. OBJECTIVES: This study reports the α-amylase and α-glucosidase inhibitory activities of dichloromethane extract and bioactive compounds isolated from Ferulago bracteata Boiss. & Hausskn. roots. MATERIALS AND METHODS: The isolated compounds obtained from dichloromethane extract of Ferulago bracteata roots through bioassay-guided fractionation and isolation process were evaluated for their in vitro α-amylase and α-glucosidase inhibitory activities at 5000-400 µg/mL concentrations...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29224384/new-coumarin-from-the-roots-of-prangos-pabularia
#5
Sodik Numonov, Khayrulla Bobakulov, Mukhabbat Numonova, Farukh Sharopov, William N Setzer, Qosimjon Khalilov, Nurmirza Begmatov, Maidina Habasi, Haji Akber Aisa
The new coumarin 1, yuganin A (7-methoxy-8-((1S,2S)-1,2,3-trihydroxy-3-methylbutyl)-2H-chromen-2-one) along with nine known coumarins, heraclenol 3'-O-β-D-glucopyranoside (2), oxypeucedanin hydrate 3'-O-β-D-glucopyranoside (3), heraclenol (4), oxypeucedanin hydrate (5), osthole (6), oxypeucedanin (7), heraclenin (8), isoimperatorin (9), imperatorin (10) and the disaccharide sucrose (11), have been isolated from the roots of Prangos pabularia, and the structures of these isolated compounds were elucidated by spectroscopic means, especially, UV, HR-ESIMS, and 1D and 2D NMR spectroscopy...
December 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29206919/identification-and-quantification-of-four-anthraquinones-in-rhubarb-and-its-preparations-by-gas-chromatography-mass-spectrometry
#6
Heshuang Dai, Zhiqiong Chen, Bing Shang, Qinhua Chen
A gas chromatographic-mass spectrometric (GC-MS) method was developed for the determination of four anthraquinones found in rhubarb. Chrysophanol, physcion, aloe-emodin and emodin were confirmed by GC-MS and the possible main cleavage pathways of fragment ions are discussed in this study. Rhubarb is a traditional Chinese medicinal herb which required an effective evaluation method to quantitate the four major active anthraquinone compounds described. The determinations of analytes were accomplished by GC-MS using osthole as an internal standard...
December 1, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29151553/chinese-single-herbs-and-active-ingredients-for-postmenopausal-osteoporosis-from-preclinical-evidence-to-action-mechanism
#7
Jing Lin, Jun Zhu, Yan Wang, Na Zhang, Hans-Jürgen Gober, Xuemin Qiu, Dajin Li, Ling Wang
Postmenopausal osteoporosis is a systemic metabolic skeletal disease generally ascribable to a dearth of estrogen. Whether traditional Chinese medicine is effective in management of postmenopausal osteoporosis remains unclear. This article reviews the experimental evidence of both in vitro and in vivo preclinical studies with the theme of the application of Chinese single herbs and active ingredients in postmenopausal osteoporosis. It includes three single herbs (Herba Epimedium, Rhizoma Drynariae, and Salvia miltiorrhiza) and eight active ingredients (saikosaponins, linarin, echinacoside, sweroside, psoralen, poncirin, vanillic acid, and osthole)...
2017: Bioscience Trends
https://www.readbyqxmd.com/read/29146527/osthole-attenuates-right-ventricular-remodeling-via-decreased-myocardial-apoptosis-and-inflammation-in-monocrotaline-induced-rats
#8
Yeli Li, Yiqi Li, Fuguo Shi, Lina Wang, Lisheng Li, Danli Yang
Osthole (Ost) is a coumarin that exhibits wide pharmacological effects in the cardiovascular system. However, whether Ost can inhibit apoptosis and inflammation in right ventricle (RV) cardiomyocytes and prevent RV remodeling is not clear. This study was designed to investigate the effect of Ost on RV remodeling and the underlying mechanism. By applying a monocrotaline (MCT)-induced rat model, the effect of Ost on RV remodeling was investigated. Rats were given a single dose of MCT (50mg⁄kg) subcutaneously (s...
November 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29052396/-effect-of-wintergreen-oil-on-in-vitro-transdermal-permeation-of-osthole-and-geniposide
#9
Xue-Cheng Gao, Yan Tong
The aim of this study was to investigate the transdermal penetration enhancement effect of wintergreen oil and its action mechanisms. The in vitro transdermal tests were carried out to study the transdermal penetration enhancement effect of wintergreen oil by using osthole and geniposide as the lipophilic and hydriphilic model drugs. Fourier-transform infrared spectroscopy was used to investigate the effect of wintergreen oil on the molecular structure of rat stratum corneum, and the scanning electron microscope was employed to observe the change of rat skin surface after treatment by the oil...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29022574/osthole-prevents-acetaminophen-induced-liver-injury-in-mice
#10
Yun Cai, Wu Sun, Xin-Xin Zhang, Yan-Die Lin, Hao Chen, Hao Li
Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Osthole, a natural coumarin found in traditional Chinese medicinal herbs, has therapeutic potential in the treatment of various diseases. In this study, we investigated the effects of osthole against APAP-induced hepatotoxicity in mice. Mice were administered osthole (100 mg·kg(-1)·d(-1), ip) for 3 d, then on the fourth day APAP (300 mg/kg, ip) was co-administered with osthole. The mice were euthanized post-APAP, their serum and livers were collected for analysis...
October 12, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28991209/design-synthesis-and-antifungal-activity-of-psoralen-derivatives
#11
Xiang Yu, Ya Wen, Chao-Gen Liang, Jia Liu, Yu-Bin Ding, Wei-Hua Zhang
A series of linear furanocoumarins with different substituents have been designed and synthesized. Their structures were confirmed by ¹H-NMR spectroscopy, high resolution mass spectra (EI-MS), IR, and X-ray single-crystal diffraction. All of the target compounds were evaluated in vitro for their antifungal activity against Rhizoctorzia solani, Botrytis cinerea, Alternaria solani, Gibberella zeae, Cucumber anthrax, and Alternaria leaf spot at 100 μg/mL, and some of the designed compounds exhibited potential antifungal activities...
October 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28938572/osthole-inhibits-bone-metastasis-of-breast-cancer
#12
Chunyu Wu, Zhenping Sun, Baofeng Guo, Yiyi Ye, Xianghui Han, Yuenong Qin, Sheng Liu
Bone is one of the most common sites for breast cancer metastasis, which greatly contributes to patient morbidity and mortality. Osthole, a major extract from Cnidium monnieri (L.), exhibits many biological and pharmacological activities, however, its potential as a therapeutic agent in the treatment of breast cancer bone metastases remain poorly understood. In this study, we set out to investigate whether osthole could inhibit breast cancer metastasis to bone in mice and clarified the potential mechanism of this inhibition...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28924381/osthole-promotes-bone-fracture-healing-through-activation-of-bmp-signaling-in-chondrocytes
#13
Pinger Wang, Jun Ying, Cheng Luo, Xing Jin, Shanxing Zhang, Taotao Xu, Lei Zhang, Meng Mi, Di Chen, Peijian Tong, Hongting Jin
Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fracture procedure in 10-week-old C57BL/6 mice which were treated with or without Osthole. Our previous studies demonstrated that chondrocyte BMP signaling is required for bone fracture healing, in this study we also performed tibial fracture procedure in Cre-negative and Col2-Cre;Bmp2(flox/flox) conditional knockout (KO) mice (Bmp2(Col2Cre) ) to determine if Osthole enhances fracture healing in a BMP2-dependent manner...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28902342/osthole-induces-apoptosis-and-suppresses-proliferation-via-the-pi3k-akt-pathway-in-intrahepatic-cholangiocarcinoma
#14
Xingyang Zhu, Xiaoling Song, Kun Xie, Xue Zhang, Wei He, Fubao Liu
Osthole is a natural coumarin isolated from Umbelliferae plant monomers. Previous research has indicated that osthole exerts a wide variety of biological effects, acting as anti-seizure, anti-osteoporosis and anti-inflammation. However, the regulatory effect and related molecular mechanism of osthole in intrahepatic cholangiocarcinoma (ICC) remain unknown. In the present study, the authors found that osthole inhibited ICC cell lines in a dose- and time-dependent manner. Osthole also significantly induced mitochondrial-dependent apoptosis by upregulating Bax, cleaved caspase-3, cleaved caspase-9, and cleaved poly ADP-ribose polymerase expression, and by downregulating Bcl-2 expression...
October 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28810525/in-vitro-anticancer-activities-of-osthole-against-renal-cell-carcinoma-cells
#15
Lei Liu, Jun Mao, Qifei Wang, Zhiwei Zhang, Guangzhen Wu, Qizhen Tang, Bin Zhao, Lianhong Li, Quanlin Li
Renal cell carcinoma (RCC) is a common urinary malignancy that is resistant to chemotherapy and radiotherapy. Osthole, a monomer compound extracted from a traditional Chinese herb, has potent anti-tumor effects on various types of cancer cells. However, the therapeutic effects of osthole on RCC remain unclear. In our study, osthole could suppress the proliferation and colony formation of two RCC cell lines, ACHN and 786-O cells, in a dose-dependent manner. Treatment with osthole resulted in a significant, dose-dependent increase in the expression of pro-apoptotic proteins (cleaved caspase-3 and Bax) and decreased expression of anti-apoptotic proteins (Bcl-2 and survivin), which were consistent with evidence of apoptotic nuclear morphology revealed by DAPI staining...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28804614/protective-effect-of-bioactive-compounds-from-echinophora-cinerea-against-cisplatin-induced-oxidative-stress-and-apoptosis-in-the-pc12-cell-line
#16
Yald Shokoohinia, Shekoufeh Khajouei, Farahnaz Ahmadi, Nastaran Ghiasvand, Leila Hosseinzadeh
OBJECTIVES: The present study aims to evaluate the protective effect of the compounds isolated from Echinophora cinerea (E. cinerea) against oxidative stress and apoptosis induced by cisplatin (CIS) in PC12 cells. MATERIALS AND METHODS: Six compounds were isolated as quercetrin-3-O-β-D-glucopyranoside (QUE), osthol (OST), verbenone-5-O-β-D-glycopyranoside (VER), Isoimperatorin (ISO), kaempferol-3-O-β-D-glucopyranoside (KAM), and echinophorin B (ECH). For this study, we used MTT reduction assay for detection of protective effects of isolated compounds on CIS-induced cytotoxicity in PC12 cells...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28795862/antifungal-activity-of-osthol-in-vitro-and-enhancement-in-vivo-through-eudragit-s100-nanocarriers
#17
Lin-Peng Li, Xiao-Juan Wang, Jin-Yu Zhang, Lu-Lu Zhang, Yong-Bing Cao, Li-Qun Gu, Yi-Qun Yu, Qi-Lian Yang, Chun-Ying Shen, Bing Han, Yuan-Ying Jiang
No abstract text is available yet for this article.
August 10, 2017: Virulence
https://www.readbyqxmd.com/read/28782757/osthole-treatment-ameliorates-th2-mediated-allergic-asthma-and-exerts-immunomodulatory-effects-on-dendritic-cell-maturation-and-function
#18
Chen-Yuan Chiang, Chen-Chen Lee, Chia-Kwung Fan, Huei-Mei Huang, Bor-Luen Chiang, Yueh-Lun Lee
Osthole, an active component of Chinese herbal medicines, reportedly possesses various pharmacological properties and has potential therapeutic applications. This study explored the anti-allergic effects of osthole in asthmatic mice and investigated the immunomodulatory actions of osthole on dendritic cells (DCs) and T cells. Herein, we show that oral administration of osthole to BALB/c mice after ovalbumin (OVA) sensitization ameliorated all of the cardinal features of T helper 2 (Th2)-mediated allergic asthma; namely, the production of OVA-specific immunoglobulin E, airway hyperresponsiveness, airway inflammation and the production of Th2-type cytokines including interleukin (IL)-4, IL-5 and IL-13...
August 7, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28765904/osthole-protects-against-inflammation-in-a-rat-model-of-chronic-kidney-failure-via-suppression-of-nuclear-factor-%C3%AE%C2%BAb-transforming-growth-factor-%C3%AE-1-and-activation-of-phosphoinositide-3-kinase-protein-kinase-b-nuclear-factor-erythroid-derived-2-like-2-signaling
#19
Tao Huang, Zhen Dong
Multiple pharmacological applications of osthole have been previously recognized, including antioxidant, anti-inflammatory, anti‑platelet and estrogenic effects, and resistance to pain. The present study investigated the protective effects of osthole against inflammation in a rat model of chronic kidney failure (CRF) and the underlying mechanisms. Osthole treatment with significantly reversed CRF‑induced changes in serum creatinine, calcium, phosphorus and blood urea nitrogen levels in CRF rats. Male Sprague‑Dawley rats (age, 8 weeks) received 200 mg/kg 2% adenine suspension to induce CRF in the model group...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28714122/a-fast-and-accurate-method-for-the-pharmacokinetic-research-of-four-coumarin-analogs-in-fructus-cnidii-using-capillary-electro-chromatography-with-a-methacrylate-ester-based-monolithic-column
#20
Zhao Chen, Aili Xu, Xiaoli Bi, Wenhui Luo, Ji Li, Guorong Fan, Dongmei Sun
In the present study, a monolithic capillary column with higher permeability was developed for the in vivo discrimination of four coumarin analogs (bergapten, 2'-acetylangelicin, imperatorin, and osthole) that typically require long separation times in HPLC. Instead of conventional methacrylate ester monolith (containing 19.5% porogen) with insufficient permeability (K = 1.52 - 1.66 × 10(-14) M(2) ) for plasma sample, the proposed column (20.5% porogen) had better permeability (around 3.80 × 10(-14) M(2) ) while properties such as pore distribution, stability, and resolution changed slightly...
July 17, 2017: Electrophoresis
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