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https://www.readbyqxmd.com/read/28629115/osthole-enhances-osteogenesis-in-osteoblasts-by-elevating-transcription-factor-osterix-via-camp-creb-signaling-in-vitro-and-in-vivo
#1
Zhong-Rong Zhang, Wing Nang Leung, Gang Li, Siu Kai Kong, Xiong Lu, Yin Mei Wong, Chun Wai Chan
Anabolic anti-osteoporotic agents are desirable for treatment and prevention of osteoporosis and fragility fractures. Osthole is a coumarin derivative extracted from the medicinal herbs Cnidium monnieri (L.) Cusson and Angelica pubescens Maxim.f. Osthole has been reported with osteogenic and anti-osteoporotic properties, whereas the underlying mechanism of its benefit still remains unclear. The objective of the present study was to investigate the osteopromotive action of osthole on mouse osteoblastic MC3T3-E1 cells and on mouse femoral fracture repair, and to explore the interaction between osthole-induced osteopromotive effect and cyclic adenosine monophosphate (cAMP) elevating effect...
June 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28625541/plant-derived-antifungal-compounds-trigger-a-common-transcriptional-response
#2
Zhe Wang
Understanding the mechanism of action of antifungal drugs is vital for better control of mycosis, which kills >1.3 million lives every year thus remains a major health problem worldwide. In this study, we investigate the activities of three different categories of plant-derived antifungal compounds (resveratrol, honokiol and osthole) via transcriptomics and bioinformatics analysis, with the goal of discovering the common Mode-of-Action (MoA) at molecular level. The result shows that a common transcriptional response (72 gene are up-regulated while 10 genes are down-regulated, commonly) are triggered by above representative antifungal compounds in Schizosaccharomyces pombe (S...
June 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28607012/potent-in-vitro-synergism-of-fluconazole-and-osthole-against-fluconazole-resistant-candida-albicans
#3
De-Dong Li, Dong Chai, Xiao-Wen Huang, Shao-Xing Guan, Jiang Du, Hao-Yu Zhang, Yan Sun, Yuan-Ying Jiang
Osthole is a natural coumarin that exhibits wide biological and pharmacological activities such as neuroprotective, osteogenic, immunomodulation, anti-tumor and anti-inflammatory effects. In this study, we investigated the antifungal effects of osthole in vitro Checkerboard microdilution assay showed that osthole has significant synergistic effect with fluconazole against fluconazole-resistant Candida albicans Similar results was obtained from growth curve assay. Meanwhile, XTT reduction assay demonstrated the synergism of fluconazole and osthole against C...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28513464/pharmacological-features-of-osthole
#4
Agata Jarząb, Aneta Grabarska, Krystyna Skalicka-Woźniak, Andrzej Stepulak
Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities. One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L.) Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.). It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved...
May 15, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28486232/osthole-a-coumadin-analog-from-cnidium-monnieri-l-cusson-ameliorates-nucleus-pulposus-induced-radicular-inflammatory-pain-by-inhibiting-the-activation-of-extracellular-signal-regulated-kinase-in-rats
#5
Hai-Xuan Wu, Yi-Min Wang, Hui Xu, Ming Wei, Qiu-Lan He, Mei-Na Li, Lai-Bao Sun, Ming-Hui Cao
AIM: This study was aimed at assessing the role of extracellular signal regulated kinase (ERK) in mechanical allodynia resulting from lumbar disc herniation (LDH) and exploring the osthole's anti-nociceptive effect on ERK activation. METHODS: Radicular pain was generated by applying nucleus pulposus (NP) to the L5 dorsal root ganglion (DRG). Allodynia was measured using Von Frey filaments to calculate the mechanical pain threshold. Phosphorylated ERK and total ERK protein in the lumbar spinal dorsal horn was detected by using the Western blot technique...
2017: Pharmacology
https://www.readbyqxmd.com/read/28455984/osthole-inhibits-bone-metastasis-of-breast-cancer
#6
Chunyu Wu, Zhenping Sun, Baofeng Guo, Yiyi Ye, Xianghui Han, Yuenong Qin, Sheng Liu
Bone is one of the most common sites for breast cancer metastasis, which greatly contributes to patient morbidity and mortality. Osthole, a major extract from Cnidium monnieri (L.), exhibits many biological and pharmacological activities, however, its potential as a therapeutic agent in the treatment of breast cancer bone metastases remain poorly understood. In this study, we set out to investigate whether osthole could inhibit breast cancer metastasis to bone in mice and clarified the potential mechanism of this inhibition...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28448873/osthole-attenuates-lipid-accumulation-regulates-the-expression-of-inflammatory-mediators-and-increases-antioxidants-in-fl83b-cells
#7
Wen-Chung Huang, Po-Chen Liao, Chun-Hsun Huang, Sindy Hu, Shih-Chun Huang, Shu-Ju Wu
Osthole is found in Cnidium monnieri (L.) and has anti-inflammatory and anti-oxidative properties. It also inhibits the proliferation of hepatocellular carcinoma cells. This study aimed to evaluate the osthole suppressive nonalcoholic fatty liver disease effects in oleic acid (OA)-induced hepatic steatosis and if it can modulate inflammatory responses and oxidative stress. FL83B cells were pretreated with OA (250μΜ) for 24h, and then added different concentrations of osthole (3-100μM) for 24h. Subsequently, lipolysis and transcription factors of adipogenesis and phosphorylation of AMP-activated protein kinase proteins were measured...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28440419/different-effects-of-%C3%A2-borneol-and-%C3%A2-%C3%A2-borneol-on-the-pharmacokinetics-of-osthole-in-rats-following-oral-administration
#8
Dan-Dan Luo, Xiao-Ying Chen, Zhen-Biao Zhang, Chao-Yue Sun, Yi-Feng Zheng, Yu-Hong Liu, Xiu-Fen Wang, Qi Wang, Janis Ya-Xian Zhan, Zi-Ren Su
Osthole is the primary active component of a number of herbal plants such as the Cnidium monnieri fruit. In traditional Chinese herb medicine, osthole is commonly used in combination with borneol to obtain improved pharmacological effects. The aim of the present study was to investigate the effect of borneol enantiomers on the pharmacokinetics of osthole. An appropriate high‑performance liquid chromatography (HPLC) method was applied to determine the concentrations of osthole in plasma. Following oral administration of osthole alone or combined with borneol in rats, blood samples were collected and analyzed by HPLC...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28350076/osthole-enhances-trail-mediated-apoptosis-through-downregulation-of-c-flip-expression-in-renal-carcinoma-caki-cells
#9
Kyoung-Jin Min, Min Ae Han, Shin Kim, Jong-Wook Park, Taeg Kyu Kwon
Osthole, an active constituent isolated from the fruit of Cnidium monnieri (L.) Cusson, has been shown to induce various beneficial biochemical effects such as anti-inflammatory and antitumor. In the present study, we examined whether osthole could sensitize TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human renal carcinoma Caki cells. We found that osthole and TRAIL alone, had no effect on apoptosis, but combined treatment with osthole and TRAIL markedly induced apoptosis in Caki (renal carcinoma), U251MG (glioma) and MDA-MB-231 (breast carcinoma) cells...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28287022/metabolic-map-of-osthole-and-its-effect-on-lipids
#10
Qi Zhao, Xin-Mei Li, Hong-Ning Liu, Frank J Gonzalez, Fei Li
1. Osthole, a coumarin compound from plants, is a promising agent for the treatment of metabolic diseases, including hyperglycemia, fatty liver, and cancers. Studies indicate that the peroxisome proliferator-activated receptors (PPAR) α and γ are involved in the pharmacological effects of osthole. The in vitro and in vivo metabolism of osthole, and its biological activity are not completely understood. 2. In this study, UPLC-ESI-QTOFMS-based metabolomics was used to determine the metabolic pathway of osthole and its influence on the levels of endogenous metabolites...
March 13, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28281381/new-polyacetylenes-from-echinophora-cinerea-boiss-hedge-et-lamond
#11
Zohreh Jelodarian, Yalda Shokoohinia, Maryam Rashidi, Nastaran Ghiasvand, Leila Hosseinzadeh, Mehrdad Iranshahi
Echinophora cinerea aerial parts are used in folk medicine to cure gastric diseases and as a food seasoning in cheese and yogurt. Besides several pharmacological effects have been assigned to Echinophora spp., there is no phytochemical investigation on this genus other than our previous publication on flavonoids. An acetone extract of E. cinerea afforded three new (1-3) polyacetylenes, one rare monoterpenoid glycoside as verbenone-5-O-β-D-glycopyranoside (4) and one prenylated coumarin as osthol (5). The structures of all new compounds were elucidated using modern spectroscopic methods, including 2D NMR and mass analyses...
March 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28257582/osthole-prevents-cerebral-ischemia-reperfusion-injury-via-notch-signaling-pathway
#12
Junhong Guan, Xiangtai Wei, Shengtao Qu, Tao Lv, Qiang Fu, Ye Yuan
Stroke is a common cerebrovascular disease in aged population with the second leading mortality and the leading cause of permanent disability, and the ischemic stroke is the primary form. Osthole is a coumarin derivative extracted from the fruits of Cnidium monnieri (Linn.) Cuss. In this study, we established the rat middle cerebral artery occlusion/reperfusion (MCAO/R) model in vivo, and found that MCAO/R caused cerebral infarction, hippocampus neuronal injury and apoptosis, and also activated the Notch 1 signaling pathway...
March 3, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28254005/cyclodextrin-based-miniaturized-solid-phase-extraction-for-biopesticides-analysis-in-water-and-vegetable-juices-samples-analyzed-by-ultra-high-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#13
Li-Qing Peng, Li-Hong Ye, Jun Cao, Yan-Xu Chang, Qin Li, Mingrui An, Zhijing Tan, Jing-Jing Xu
A cyclodextrin-based miniaturized solid-phase extraction was developed to extract biopesticides from water and vegetable juices. The analytes were detected by ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry. In the solid-phase extraction (SPE) procedure, the liquid sample solution is passed through a packed column filled with 40mg of HP-β-CD, and then the target analytes are absorbed and finally eluted with methanol-acetic acid (90:10, v/v) into a collection tube...
July 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28236037/ppar%C3%AE-%C3%AE-antagonists-reverse-the-ameliorative-effects-of-osthole-on-hepatic-lipid-metabolism-and-inflammatory-response-in-steatohepatitic-rats
#14
Xi Zhao, Feng Wang, Ruijun Zhou, Zengyan Zhu, Meilin Xie
Our previous studies have indicated that osthole may ameliorate the hepatic lipid metabolism and inflammatory response in nonalcoholic steatohepatitic rats, but the underlying mechanisms remain unclear. This study aimed to determine whether the effects of osthole were mediated by the activation of hepatic peroxisome proliferator-activated receptor α/γ (PPARα/γ). A rat model with steatohepatitis was induced by orally feeding high-fat and high-sucrose emulsion for 6 weeks. These experimental rats were then treated with osthole (20 mg/kg), PPARα antagonist MK886 (1 mg/kg) plus osthole (20 mg/kg), PPARγ antagonist GW9662 (1 mg/kg) plus osthole (20 mg/kg) and MK886 (1 mg/kg) plus GW9662 (1 mg/kg) plus osthole (20 mg/kg) for 4 weeks...
February 25, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28221758/synthesis-and-fabrication-of-collagen-coated-ostholamide-electrospun-nanofiber-scaffold-for-wound-healing
#15
Subramani Kandhasamy, Sathiamurthi Perumal, Balaraman Madhan, Narayanan Umamaheswari, Javid Ahmad Banday, Paramasivan Thirumalai Perumal, Vichangal Pridiuldi Santhanakrishnan
A novel scaffold for effective wound healing treatment was developed utilizing natural product bearing collagen-based biocompatible electrospun nanofibers. Initially, ostholamide (OSA) was synthesized from osthole (a natural coumarin), characterized by (1)H, (13)C, DEPT-135 NMR, ESI-MS, and FT-IR spectroscopy analysis. OSA was incorporated into polyhydroxybutyrate (PHB) and gelatin (GEL), which serve as templates for electrospun nanofibers. The coating of OSA-PHB-GEL nanofibers with collagen resulted in PHB-GEL-OSA-COL nanofibrous scaffold which mimics extracellular matrix and serves as an effective biomaterial for tissue engineering applications, especially for wound healing...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28184928/osthole-inhibits-the-tumorigenesis-of-hepatocellular-carcinoma-cells
#16
Zhi-Kun Lin, Jia Liu, Guo-Qiang Jiang, Guang Tan, Peng Gong, Hai-Feng Luo, Hui-Min Li, Jian Du, Zhen Ning, Yi Xin, Zhong-Yu Wang
Hepatocellular carcinoma (HCC) accounts for approximately 90% of all cases of primary liver cancer, and the majority of patients with HCC are deprived of effective curative methods. Osthole is a Chinese herbal medicine which has been reported to possess various pharmacological functions, including hepatocellular protection. In the present study, we investigated the anticancer activity of osthole using HCC cell lines. We found that osthole inhibited HCC cell proliferation, induced cell cycle arrest, triggered DNA damage and suppressed migration in HCC cell lines...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28168604/the-natural-product-osthole-attenuates-yeast-growth-by-extensively-suppressing-the-gene-expressions-of-mitochondrial-respiration-chain
#17
Zhe Wang, Yan Shen
The fast growing evidences have indicated that the natural product osthole is a promising drug candidate for fighting several serious human diseases, for example, cancer and inflammation. However, the mode-of-action (MoA) of osthole remains largely incomplete. In this study, we investigated the growth inhibition activity of osthole using fission yeast as a model, with the goal of understanding the osthole's mechanism of action, especially from the molecular level. Microarray analysis indicated that osthole has significant impacts on gene transcription levels (In total, 214 genes are up-regulated, and 97 genes are down-regulated)...
March 2017: Current Microbiology
https://www.readbyqxmd.com/read/28164729/lc-ms-ms-analysis-and-evaluation-of-the-anti-inflammatory-activity-of-components-from-bushenhuoxue-decoction
#18
Dongdong Sun, Qiuying Yan, Xiaofang Xu, Weixing Shen, Changliang Xu, Jiani Tan, Haibin Zhang, Liu Li, Haibo Cheng
CONTEXT: BushenHuoxue decoction (BSHXD) is a Chinese medicine prescription, which is composed of nine Chinese medical materials, used to treat osteoarthritis (OA). OBJECTIVE: This study develops sensitive and convenient LC-MS/MS methods to analyze chemical components from BSHXD, and assess the anti-inflammatory activities thereof. MATERIALS AND METHODS: The chemical composition from BSHXD water extract was qualitative analyzed by high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF-MS)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28146373/osthole-inhibited-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-emt-by-suppressing-nf-%C3%AE%C2%BAb-mediated-snail-activation-in-lung-cancer-a549-cells
#19
Haitao Feng, Jin-Jian Lu, Yitao Wang, Lixia Pei, Xiuping Chen
Epithelial-mesenchymal transition (EMT), the transdifferentiation of epithelial cells into mesenchymal cells, has been implicated in the metastasis and provides novel strategies for cancer therapy. Osthole (OST), a dominant active constituent of Chinese herb Cnidium monnieri, has been reported to inhibit cancer metastasis while the mechanisms remains unclear. Here, we studied the inhibitory effect and mechanisms of OST on TGF-β1-induced EMT in A549 cells. Cells were treated with TGF-β1 in the absence and presence of OST...
February 1, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28143779/anti-asthmatic-activity-of-osthole-in-an-ovalbumin-induced-asthma-murine-model
#20
Jingjing Wang, Yunhe Fu, Zhengkai Wei, Xuexiu He, Mingyu Shi, Jinhua Kou, Ershun Zhou, Weijian Liu, Zhengtao Yang, Changming Guo
Osthole, an active coumarin extracted from the dried fruits of Cnidium monnieri (L.) Cusson, is known to possess a variety of pharmacological activities. In the present study, we investigated and illuminated the mechanisms underlying the protective effects of osthole in an experimental model of allergic asthma. Our results show that osthole treatment significantly reduced the OVA-induced increase in serum IgE and inflammatory cytokines (IL-4, IL-5, IL-13) in bronchoalveolar lavage fluid (BALF), and decreased the recruitment of inflammatory cells in BALF and the lung...
May 2017: Respiratory Physiology & Neurobiology
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