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ulcerated hemangioma

Maria S Kryatova, Barbara M Rainer, Jiawei Zhao, Vadim A Villarroel, Anna Yasmine Kirkorian, Anna L Grossberg, Katherine B Puttgen, Bernard A Cohen
BACKGROUND/OBJECTIVES: Nasal infantile hemangiomas (IHs) pose serious medical complications and psychosocial stress if tumor involution is incomplete or prolonged. The objective was to determine which IH characteristics are associated with complications and are predictive of outcome, assessed as the presence of IHs or residual skin changes upon kindergarten entry, to better manage these lesions and counsel families. METHODS: A retrospective chart review of all patients seen in the Division of Pediatric Dermatology at Johns Hopkins Medicine between 2001 and 2014 for nasal IHs (N = 89) was performed...
October 4, 2016: Pediatric Dermatology
Christina Boull, Sheilagh M Maguiness
Congenital hemangiomas are rare solitary vascular tumors that do not proliferate after birth. They are characterized as either rapidly involuting congenital hemangiomas (RICHs) or noninvoluting congenital hemangiomas (NICHs) based on their clinical progression. NICHs have no associated complications, but are persistent. RICH, while usually asymptomatic, may ulcerate or bleed early in their presentation, but involute quickly during the first few months of life. Hepatic RICHs are not associated with cutaneous RICHs, but may result in high-output cardiac failure due to arteriovenous or portovenous shunting...
September 2016: Seminars in Cutaneous Medicine and Surgery
Carol Erin Cheng, Sheila Fallon Friedlander
Infantile hemangiomas (IHs) are the most common vascular tumors of infancy. While the majority regress without the need for intervention, approximately 10%, often site dependent, can cause serious complications and require treatment. IH complications can be categorized as life threatening, obstructive, ulcerative or disfiguring. Life threatening complications include airway and hepatic IHs. Functional complications obstructing vital structures or impairing function include periocular, nasal, labial, parotid, auricular, and breast IHs...
September 2016: Seminars in Cutaneous Medicine and Surgery
Ting-Lin B Yang, Patrick McMahon, Diva D De Léon, James R Treat
Infantile hemangiomas (IHs) are the most common pediatric vascular tumors. They require therapy when they cause severe complications such as ulceration, amblyopia, or airway constriction. Propranolol is the only treatment that the U.S. Food and Drug Administration has approved for complicated IHs and has become first-line therapy for IHs that need to be treated. Older therapies such as systemic corticosteroids and surgery are now rarely used. Propranolol can have potentially serious adverse side effects, including bradycardia, hypotension, and hypoglycemia...
August 30, 2016: Pediatric Dermatology
Nicola di Meo, Giuseppe Stinco, Alessandro Gatti, Mattia Fadel, Silvia Vichi, Giusto Trevisan
Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm...
June 2016: Acta Dermatovenerologica Croatica: ADC
Ioannis Patoulias, Konstantinos Farmakis, Christos Kaselas, Dimitrios Patoulias
Deep scrotal hemangiomas are rare. Less than 50 case reports have been published. After systematic research of the literature, we found less than 5 cases of ulcerated scrotal hemangioma. The aim of this case report is to illustrate the challenges of scrotal hemangiomas pose and their potential therapies based on the successful surgical treatment of an ulcerated scrotal hemangioma in an 18-month-old male patient.
2016: Case Reports in Urology
Daniel A Yanes, Gregory D Pearson, Patricia M Witman
BACKGROUND: Infantile hemangiomas of the lip are potentially problematic because of high visibility and risk of disfigurement and ulceration. This study examined sizes, patterns, and locations of lip hemangiomas, their prognostic value, and their implications in hemangioma pathogenesis. METHODS: Records of 106 patients seen for lip hemangiomas from 2006 to 2013 at Nationwide Children's Hospital were reviewed. Localized hemangiomas were mapped to a location on the lip based on their focus...
September 2016: Pediatric Dermatology
Harveen Kaur Gulati, Avinash R Joshi, Mani Anand, S D Deshmukh
Melanocytic schwannoma (MS) is an extremely rare soft tissue tumor accounting for less than 1% of all primitive nerve sheath tumors, with a predilection for spinal nerve involvement. To date, only 20 cases of cutaneous/subcutaneous MS have been described in literature. Here, we describe a case of MS presenting as a subcutaneous nodule in a 22-year-old male in right thigh. On examination, the nodule measured 2.5 × 2.0 × 1.5 cm with overlying skin showing a bluish hue and an ulcer. With a preoperative diagnosis of hemangioma, the patient was taken up for wide local excision and was diagnosed as a case of non psammomatous melanocytic schwannoma based on clinical, histological, and immunohistochemical studies...
July 2016: Asian Journal of Neurosurgery
Giovanna Stringari, Giulia Barbato, Matteo Zanzucchi, Maddalena Marchesi, Giuseppe Cerasoli, Bertrand Tchana, Alessandro Gritti, Valeria Boccaletti, Alfonsa Anna Lombardi, Nicola Carano
Infantile hemangiomas (IH) complicated by ulceration, disfigurement, functional impairment or life-threatening conditions need early, safe and effective treatment. This study explores the impact of propranolol on complicated IH. We report our experience of 62 patients treated with oral propranolol for complicated IH. The effect of propranolol was assessed using a score on a visual analogue scale integrated with echo, magnetic resonance or endoscopic findings. The average age at the beginning of the treatment was seven months [standard deviation (SD)±8...
2016: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
Kamalvir Gill, Cheryl Bayart, Ritu Desai, Alex Golden, Patricia Raimer, Joan Tamburro
Combigan (Allergan, Irvine, CA) is an ophthalmic solution that combines 0.2% brimonidine, a selective α-2 adrenergic agonist, with 0.5% timolol, a nonselective β-adrenergic antagonist. It is approved for the reduction of intraocular pressure in patients with glaucoma or ocular hypertension. There have been recent reports of successful treatment of superficial infantile hemangiomas (IHs) using Combigan topically. We report the case of a 2-month-old girl who developed life-threatening brimonidine toxicity requiring intubation and mechanical ventilation secondary to central nervous system depression and apnea after topical application to an ulcerated IH...
July 2016: Pediatric Dermatology
JiaDe Yu, Mohit Maheshwari, Andrew B Foy, Casey M Calkins, Beth A Drolet
No abstract text is available yet for this article.
August 2016: Journal of Pediatrics
Benjamin Henning, Pascale Stieger, Jivko Kamarachev, Reinhard Dummer, Simone M Goldinger
Cutaneous toxicities under therapy with selective BRAF inhibitors such as vemurafenib or encorafenib (LGX818) are frequent, including plantar hyperkeratosis, squamous cell carcinoma, and second primary melanoma. Pyogenic granuloma is a benign, rapidly growing, eruptive hemangioma that often bleeds and ulcerates. Common causes are mechanical trauma and cast immobilization, as well as multiple drugs such as retinoids and antineoplastic agents. However, the development of pyogenic granuloma under treatment with encorafenib (LGX818) has not yet been reported...
June 2016: Melanoma Research
Antonia Reimer, Maren Fliesser, Peter H Hoeger
BACKGROUND: From 18% to 30% of infantile hemangiomas (IH) are located on the extremities (IHE). They can be divided into localized, segmental, and minimal or arrested growth (IH-MAG) subtypes. OBJECTIVE: We sought to correlate localization of IHE with the anatomy of the arterial vascular supply. METHODS: All children with segmental IHE and IH-MAG presenting to our department of pediatric dermatology from 2002 to 2015 were evaluated. Hemangiomas were mapped and their patterns were analyzed...
September 2016: Journal of the American Academy of Dermatology
Yuanjun Li, Yunfeng Hu, Haipian Li, Liehua Deng
BACKGROUND: Pulsed dye laser (PDL) treatment has been shown to be effective for the management of ulcerated areas of hemangiomas. However, targeting deeper dermal lesions requires a laser system that penetrates more deeply than a PDL. Thus, we applied a dual-wavelength 595- and 1064-nm laser system to the treatment of ulcerated hemangiomas. MATERIALS AND METHODS: Twenty-two infants with ulcerated hemangiomas (mean are, 3.8 cm(2)) were reviewed. Ulcers were treated by debridement and the surface received 595-nm PDL treatment at 4-5 J/cm(2) with a pulse width of 0...
April 13, 2016: Journal of Dermatological Treatment
Ayşe Bozkurt Turhan, Özcan Bör, Zeynep Canan Özdemir
BACKGROUND: Infantile hemangiomas (IHs) are the most common soft tissue tumors of infancy. Although spontaneous regression is expected, medical treatment is needed in approximately 10-20% of cases. AIMS: We aimed to assess the safety and efficacy of systemic propranolol for the treatment of IH. PATIENTS/METHODS: Medical records of 34 eligible patients were analyzed retrospectively. RESULTS: Treatment indications were local complications (hemorrhage, ulceration) in 38...
September 2016: Journal of Cosmetic Dermatology
Chen Shuming, Chen Shaoquan, Zhang Zaizhong, Li Chengjin, Xia Yin, Lin Chen, Huang Qingjin, Wang Lie
OBJECTIVE: To explore the effect and safety of topical propranolol hydrochloride gel for treatment of infantile hemangioma. METHODS Thirty nude mice (BALA/c, nu/nu) were divided into three groups, experimental group, control group and normal group. Human hemangioma endothelial cells cultured in vitro were injected subcutaneously in experimental group and control group to establish infantile hemangioma model. Topical propranolol hydrochloride gel was applied on the surface of the hemangioman in experimental group and normal group...
November 2015: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
Yu Linjun, Xu Jiachuan, Su Baoli, Xiong Qixing, Luo Chunfen
OBJECTIVE: To dicuss the clinical efficacy of Timolol Maleate Eye Drops in the treatment of superficial infantile hemangiomas. Methods From April 2012 to May 2014, 210 patients with superficial infantile hemangiomas were included. According to the parents' choice, a total of 176 cases were treated with Timolol Maleate Eye Drops as the treatment group, and the 34 cases who received the treatment of "wait and see" was included in the control group. In the treatment group, the gauzes were dipped into the eye drops and putted evenly on the surface of the hemangioma, 3-4 times daily and lasted for more than 20 minutes...
November 2015: Zhonghua Zheng Xing Wai Ke za Zhi, Zhonghua Zhengxing Waike Zazhi, Chinese Journal of Plastic Surgery
Nafiseh Shamloo, Ali Lotfi, Hamid Reza Motazadian, Hamed Mortazavi, Maryam Baharvand
The tongue has been globally considered as an indicator of general health for millennia. This study aimed to determine the prevalence and distribution of tongue lesions in an Iranian population. In this retrospective study, data from 6,435 oral biopsy reports over a 22-year period (1992-2014) were retrieved from archives of Oral and Maxillofacial Pathology Department, Shahid Beheshti Dental School, Tehran, Iran. These reports were analyzed according to age, sex, type of lesion and location. Prevalence of tongue lesions were reported as percentages...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Chun-Shin Chang, Gavin Chun-Wui Kang
Infantile hemangiomas (IHs) are the most common benign pediatric soft-tissue tumors. Ulceration-the most frequent complication of IH-tends to heal poorly and is associated with pain, bleeding, infection, and scarring. Mainstay treatment modalities include propranolol (β-blocker) and corticosteroids, whose effectiveness is countered by a need for long-term medication and risk of systemic adverse effects and ulcer recurrence. A 3-month-old infant presented to us with a large, medial thigh-ulcerated IH that progressed despite 2 prior months of dressings and topical antimicrobials...
February 2016: Plastic and Reconstructive Surgery. Global Open
R-Z Shao, D-H Zhao, J Li
OBJECTIVE: To explore the effective and convenient methods of infantile hemangioma treatment. PATIENTS AND METHODS: From October 2010 to June 2014, 31 infantile hemangioma patients admitted to our hospital, were administered propranolol combined with betamethasone injection treatment of lesions. RESULTS: All patients were followed for 6 months-2 years. In treated patients, 24 patients with tumor had complete or nearly complete remission while 6 patients showed partial regression...
2016: European Review for Medical and Pharmacological Sciences
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