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https://www.readbyqxmd.com/read/29782620/genomic-big-data-hitting-the-storage-bottleneck
#1
Louis Papageorgiou, Picasi Eleni, Sofia Raftopoulou, Meropi Mantaiou, Vasileios Megalooikonomou, Dimitrios Vlachakis
During the last decades, there is a vast data explosion in bioinformatics. Big data centres are trying to face this data crisis, reaching high storage capacity levels. Although several scientific giants examine how to handle the enormous pile of information in their cupboards, the problem remains unsolved. On a daily basis, there is a massive quantity of permanent loss of extensive information due to infrastructure and storage space problems. The motivation for sequencing has fallen behind. Sometimes, the time that is spent to solve storage space problems is longer than the one dedicated to collect and analyse data...
2018: EMBnet.journal
https://www.readbyqxmd.com/read/29782524/leucocytes-telomere-length-and-breast-cancer-risk-susceptibility-a-case-control-study
#2
Sofia Pavanello, Liliana Varesco, Viviana Gismondi, Paolo Bruzzi, Claudia Bolognesi
BACKGROUND: Telomere length in peripheral blood leukocytes (PBL-TL) was proposed as a biomarker of cancer risk. Recent scientific evidence suggested PBL-TL plays a diverse role in different cancers. Inconsistent results were obtained on PBL-TL in relation to breast cancer risk and specifically to the presence of BRCA1 and BRCA2 mutations. The aim of the present case-control study was to analyse the correlation between family history of breast cancer or presence of a BRCA mutation and PBL-TL in the hypothesis that TL is a modifier of cancer risk...
2018: PloS One
https://www.readbyqxmd.com/read/29771232/methicillin-resistant-staphylococcus-argenteus-misidentified-as-methicillin-resistant-staphylococcus-aureus-emerging-in-western-sweden
#3
Erika Tång Hallbäck, Nahid Karami, Ingegerd Adlerberth, Sofia Cardew, Maria Ohlén, Hedvig Engström Jakobsson, Liselott Svensson Stadler
Two strains included in a whole-genome sequencing project for methicillin-resistant Staphylococcus aureus (MRSA) were identified as non-Staphylococcus aureus when the sequences were analysed using the bioinformatics software ALEX (www.1928diagnostics.com, Gothenburg, Sweden). Sequencing of the sodA gene of these strains identified them as Staphylococcus argenteus. The collection of MRSA in western Sweden was checked for additional strains of this species. A total of 18 strains of S. argenteus isolated between 2011 and December 2017 were identified...
May 17, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29768526/validation-and-invariance-across-gender-of-the-beliefs-about-appearance-scale-baas-in-a-community-sample-of-heterosexual-adults-in-a-committed-relationship
#4
Patrícia M Pascoal, Maria-João Alvarez, Magda Sofia Roberto
OBJECTIVE: To evaluate the psychometric properties of the Beliefs About Appearance Scale (BAAS) in terms of its factorial structure and invariance, reliability, and validity when applied to adults from the community. METHODS: Participants consisted of 810 heterosexual Portuguese individuals in a committed relationship. As a confirmatory factor analysis did not support the original structure of the BAAS, an exploratory factor analysis was performed. RESULTS: A 12-item version was extracted comprising two dimensions: one personal and the other social...
May 14, 2018: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/29765702/is-radiographic-progression-in-radiographic-axial-spondyloarthritis-related-to-matrix-metalloproteinase-degradation-of-extracellular-matrix
#5
Anne Sofie Siebuhr, Desirée van der Heijde, Anne-C Bay-Jensen, Morten Asser Karsdal, Robert Landewé, Astrid van Tubergen, Sofia Ramiro
Background: Radiographic axial spondyloarthritis (r-axSpA) is associated with extracellular matrix (ECM) remodelling of affected tissues. We investigated whether there was a relationship between biomarkers of ECM remodelling and 2-year radiographic progression in r-axSpA. Methods: Patients from the Outcome in Ankylosing Spondylitis International Study (OASIS) were included if they had serum, clinical and spinal radiographic assessments available at baseline and 2 years later...
2018: RMD Open
https://www.readbyqxmd.com/read/29763572/determinants-of-response-to-roflumilast-in-severe-copd-pooled-analysis-of-two-randomized-trials
#6
Fernando J Martinez, Klaus F Rabe, Peter M A Calverley, Leonardo M Fabbri, Sanjay Sethi, Emilio Pizzichini, Andrew McIvor, Antonio Anzueto, Vijay K T Alagappan, Shahid Siddiqui, Colin Reisner, Sofia Zetterstrand, Jonas Román, Debasree Purkayastha, Nitin Bagul, Stephen I Rennard
RATIONALE: Roflumilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease associated with chronic bronchitis and a history of exacerbations. Further characterization of patients most likely to benefit is warranted. OBJECTIVES: Define characteristics that most robustly identify patients who derive greatest exacerbation risk reduction with roflumilast. METHODS: Predefined, pooled analyses of REACT (NCT01329029) and RE2 SPOND (NCT01443845) multicenter, randomized, double-blind, placebo-controlled studies...
May 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29753206/avoidable-colorectal-cancer-cases-in-denmark-the-impact-of-red-and-processed-meat
#7
Sofia Lourenço, Vibeke Berglund Gunge, Therese M-L Andersson, Camilla Liv Erthmann Andersen, Anne-Sofie Q Lund, Brian Køster, Gitte Laub Hansen
BACKGROUND: High red and processed meat intakes are associated with increased colorectal cancer (CRC) risk. The effect of eliminating or reducing red and processed meat consumption on CRC burden was not previously quantified in Denmark. The aim of this study was to calculate the possible effects of reductions in red and processed meat consumption on future CRC incidence in the Danish adult population. METHODS: Under six scenarios of prevalence exposure (meat consumption) the number of CRC cases in Denmark for a 30-year period (2016-2045) was estimated and compared to the projected number of CRCs if the prevalence of meat consumption remains constant...
May 9, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29745894/association-between-dietary-and-metabolic-factors-and-igm-antibodies-to-phosphorylcholine-and-malondialdehyde-in-patients-with-systemic-lupus-erythematosus-and-population-based-matched-controls
#8
Cecilia Lourdudoss, Sofia Ajeganova, Johan Frostegård
OBJECTIVES: Immunoglobulin M (IgM) antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) are implicated in systemic lupus erythematosus (SLE) as markers with potential protective properties. Low IgM anti-PC levels are more common in SLE than in control population. Little is known what influences the levels of these antibodies. We here studied associations between dietary and metabolic factors and levels of IgM anti-PC and anti-MDA. METHODS: This study included 109 SLE patients and 106 controls from SLE Vascular Investigation Cohort (SLEVIC)...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745752/predicting-volleyball-serve-reception-at-group-level
#9
Ana Paulo, Frank T J M Zaal, Ludovic Seifert, Sofia Fonseca, Duarte Araújo
In a group-serve-reception task, how does serve-reception become effective? We addressed "who" receives/passes the ball, what task-related variables predict action mode selection and whether the action mode selected was associated with reception efficacy. In 182 serve-receptions we tracked the ball and the receivers' heads with two video-cameras to generate 3D world-coordinates reconstructions. We defined receivers' reception-areas based on Voronoi diagrams (VD). Our analyses of the data showed that this approach was accurate in describing "who" receives the serve in 95...
May 10, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29741624/anaerobic-carbon-monoxide-metabolism-by-pleomorphomonas-carboxyditropha-sp-nov-a-new-mesophilic-hydrogenogenic-carboxydotroph
#10
Sofia Esquivel-Elizondo, Juan Maldonado, Rosa Krajmalnik-Brown
Carbon monoxide (CO)-metabolism and phenotypic and phylogenetic characterization of a novel anaerobic, mesophilic and hydrogenogenic carboxydotroph are reported. Strain SVCO-16 was isolated from anaerobic sludge and grows autotrophically and mixotrophically with CO. The genes cooS and cooF, coding for a CO dehydrogenase complex, and genes similar to hycE2, encoding a CO-induced hydrogenase, were present in its genome. The isolate produces H2 and CO2 from CO, and acetate and formate from organic substrates. Based on the 16S rRNA sequence, it is an Alphaproteobacterium most closely related to the genus Pleomorphomonas (98...
June 1, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29733921/circulation-assessment-by-automated-external-defibrillators-during-cardiopulmonary-resuscitation
#11
Jesus M Ruiz, Sofía Ruiz de Gauna, Digna M González-Otero, Purificación Saiz, J Julio Gutiérrez, Jose F Veintemillas, Jose M Bastida, Daniel Alonso
AIM: To design and evaluate a simple algorithm able to discriminate pulsatile rhythms from pulseless electrical activity during automated external defibrillator (AED) analysis intervals, using the ECG and the transthoracic impedance (TI) acquired from defibrillation pads. METHODS: ECG and TI signals from out-of-hospital AED recordings were retrospectively analysed. Experts annotated the cardiac rhythm during AED analysis intervals and at the end of each episode...
May 4, 2018: Resuscitation
https://www.readbyqxmd.com/read/29729686/treatments-for-bulimia-nervosa-a-network-meta-analysis
#12
Eric Slade, Edna Keeney, Ifigeneia Mavranezouli, Sofia Dias, Linyun Fou, Sarah Stockton, Leanne Saxon, Glenn Waller, Hannah Turner, Lucy Serpell, Christopher G Fairburn, Tim Kendall
BACKGROUND: Bulimia nervosa (BN) is a severe eating disorder that can be managed using a variety of treatments including pharmacological, psychological, and combination treatments. We aimed to compare their effectiveness and to identify the most effective for the treatment of BN in adults. METHODS: A search was conducted in Embase, Medline, PsycINFO, and Central from their inception to July 2016. Studies were included if they reported on treatments for adults who fulfilled diagnostic criteria for BN...
May 6, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29723127/ethics-and-sexual-health-exploration-of-the-ethical-code-of-conduct-for-physiotherapists-concerning-sexual-health-in-clinical-practice
#13
Kristina Areskoug-Josefsson, Sofia Kjellström
Physiotherapists have an important role in sexual health, but there are specific ethical considerations regarding sexuality and the practice of physiotherapy which require serious consideration. This article aims to illustrate how the professional ethical code of physiotherapy can serve as a tool for ethical clinical reasoning regarding sexual health in clinical physiotherapy practice. We analyse the ethical codes for physical therapy, in relation to a definition of sexual health and the declaration of sexual rights...
May 3, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29703112/family-members-experiences-of-care-of-the-dying-in-residential-care-homes-where-the-liverpool-care-pathway-was-used
#14
Sofia Andersson, Olav Lindqvist, Carl-Johan Fürst, Margareta Brännström
BACKGROUND: Residential care homes (RCHs) are increasingly becoming a common place of death for older people. AIM: The aim of this study was to describe family members' experiences of care of the dying in RCHs where the Liverpool care pathway for the dying patient was used. METHODS: This study had a descriptive qualitative study design. Fifteen (n=15) individual interviews were analysed using qualitative content analysis. RESULTS: The analysis resulted in three themes: being confident in a familiar and warm atmosphere, being involved vs not being involved in end-of-life (EoL) care, and being consoled by witnessing the health professional's endeavour to relieve suffering...
April 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29686658/gut-microbiota-profiling-and-gut-brain-crosstalk-in-children-affected-by-pediatric-acute-onset-neuropsychiatric-syndrome-and-pediatric-autoimmune-neuropsychiatric-disorders-associated-with-streptococcal-infections
#15
Andrea Quagliariello, Federica Del Chierico, Alessandra Russo, Sofia Reddel, Giulia Conte, Loris R Lopetuso, Gianluca Ianiro, Bruno Dallapiccola, Francesco Cardona, Antonio Gasbarrini, Lorenza Putignani
Pediatric acute-onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections syndrome (PANDAS) are conditions that impair brain normal neurologic function, resulting in the sudden onset of tics, obsessive-compulsive disorder, and other behavioral symptoms. Recent studies have emphasized the crosstalk between gut and brain, highlighting how gut composition can influence behavior and brain functions. Thus, the present study investigates the relationship between PANS/PANDAS and gut microbiota ecology...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29682293/methodological-aspects-of-serosurveillance-in-resource-poor-settings
#16
Susanna Sternberg Lewerin, Cecilia Wolff, Charles Masembe, Karl Ståhl, Sofia Boqvist, Mikael Andersson Franko
Animal production is important for the agricultural economy in low-income countries, but is threatened by infectious diseases. Serosurveys are conducted for different reasons such as disease detection, risk factor studies, disease monitoring and establishing disease-free status. Most reports on such serosurveys include some discussion about methodological constraints but still, by necessity, rely on serological results for case definition. This study uses a cross-sectional serosurvey for foot-and-mouth disease (FMD), Rift Valley fever (RVF) and contagious bovine pleuropneumonia (CBPP) in cattle in three districts in Western Uganda to illustrate the limitations of this approach, addressing the questions of what flaws can be expected in sampling and diagnostics and how these influence the results...
2018: Veterinary Record Open
https://www.readbyqxmd.com/read/29677091/factors-associated-with-revision-surgery-after-internal-fixation-of-hip-fractures
#17
Sheila Sprague, Emil H Schemitsch, Marc Swiontkowski, Gregory J Della Rocca, Kyle J Jeray, Susan Liew, Gerard P Slobogean, Sofia Bzovsky, Diane Heels-Ansdell, Qi Zhou, Mohit Bhandari
BACKGROUND: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery...
May 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29669575/effects-of-senolytic-drugs-on-human-mesenchymal-stromal-cells
#18
Clara Grezella, Eduardo Fernandez-Rebollo, Julia Franzen, Mónica Sofia Ventura Ferreira, Fabian Beier, Wolfgang Wagner
BACKGROUND: Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effects of senolytic drugs have not been analysed during replicative senescence of human mesenchymal stromal cells (MSCs). METHODS: In this study, we tested four potentially senolytic drugs: ABT-263 (navitoclax), quercetin, nicotinamide riboside, and danazol...
April 18, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29661311/isolation-and-characterisation-of-microcrystalline-cellulose-and-cellulose-nanocrystals-from-coffee-husk-and-comparative-study-with-rice-husk
#19
Sofía Collazo-Bigliardi, Rodrigo Ortega-Toro, Amparo Chiralt Boix
Cellulosic material from coffee husk has not been previously studied despite being a potential source of reinforcing agents for different applications. This material has been extracted and characterised from coffee husk, in parallel with previously studied rice husk. Samples have been analysed as to their ability to obtain cellulosic fibres and cellulose nanocrystals (CNC) by applying alkali and bleaching treatments and final sulphuric acid hydrolysis. Microstructural changes were analysed after treatments, and the size and aspect ratio of CNCs were determined...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29653321/neurodevelopmental-comorbidities-and-seizure-control-24-months-after-a-first-unprovoked-seizure-in-children
#20
Eva Åndell, Torbjörn Tomson, Sofia Carlsson, Kristina Tedroff, Per Åmark
PURPOSE: To follow children with newly diagnosed unprovoked seizures to determine (1) whether the prevalence of neurodevelopmental comorbidities and cerebral palsy (CP) changed after the initial seizure, and (2) the association between studied comorbidities and seizures 13-24 months after seizure onset or initiation of treatment. METHODS: Analyses were based on 750 children (28 days-18 years) with a first unprovoked seizure (index) included in a population-based Incidence Registry in Stockholm between 2001 and 2006...
March 20, 2018: Epilepsy Research
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