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https://www.readbyqxmd.com/read/28933990/influence-of-salinomycin-treatment-on-division-and-movement-of-individual-cancer-cells-cultured-in-normoxia-or-hypoxia-evaluated-with-time-lapse-digital-holographic-microscopy
#1
Sofia Kamlund, Daniel Strand, Birgit Janicke, Kersti Alm, Stina Oredsson
Most studies on new cancer drugs are based on population-derived data, where the absence of response of a small population may pass unnoticed. Thus, individual longitudinal tracking of cells is important for the future development of efficient cancer treatments. We have used digital holographic microscopy to track individual JIMT-1 human breast cancer cells and L929 mouse fibroblast cultivated in normoxia or hypoxia. In addition, JIMT-1 cells were treated with salinomycin, a cancer stem cell targeting compound...
September 21, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28928074/curcumin-or-combined-curcuminoids-are-effective-in-lowering-the-fasting-blood-glucose-concentrations-of-individuals-with-dysglycemia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
Ingrid Sofia Vieira de Meloa, Aldenir Feitosa Dos Santosb, Nassib Bezerra Buenoc
Curcuminoids have received considerable attention as therapeutical adjuvants in the treatment of dysglycemia. The purpose of this meta-analysis was to evaluate whether the supplementation of turmeric extract, curcuminoids and/or isolated curcumin is more effective than placebo in decreasing fasting blood glucose (FBG) in adults. MEDLINE, CENTRAL, ScienceDirect and gray literature databases were searched. Randomized controlled trials with the following criteria were included: (1) studied individuals older than 18 years, supplemented with curcumin, curcuminoids and/or turmeric extract (2) had a follow-up ≥4 weeks (3) used a placebo group...
September 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28918444/left-atrial-volume-computed-by-3d-rotational-angiography-best-predicts-atrial-fibrillation-recurrence-after-circumferential-pulmonary-vein-isolation
#3
Teresa Strisciuglio, Giuseppe Di Gioia, Sofia Chatzikyriakou, Etel Silva Garcia, Emanuele Barbato, Peter Geelen, Tom De Potter
Left atrium (LA) size is a well-studied predictor of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). Yet, there is still little agreement on the best imaging technique to size the LA, and on the most appropriate sizing parameter. Volumetric assessment of LA with three-dimensional rotational angiography (3DRA LA volume index) might be a valid alternative to the commonly used transthoracic echocardiography (TTE LA volume index). The aim of our study was to investigate whether LA volume by 3DRA at the time of PVI is able to predict the risk of atrial fibrillation recurrence...
September 16, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28893409/equivalence-in-the-health-assessment-questionnaire-haq-across-socio-demographic-determinants-analyses-within-quest-ra
#4
Monika Hifinger, Sam Norton, Sofia Ramiro, Polina Putrik, Tuulikki Sokka-Isler, Annelies Boonen
OBJECTIVES: To investigate potential bias in scores of the Health Assessment Questionnaire (HAQ) related to socio-demographic (SD) background of patients with rheumatoid arthritis (RA). METHODS: Data from the Quantitative Standard Monitoring of Rheumatoid Arthritis study (QUEST-RA), comprising 9022 patients were analysed. Physical function was assessed through 30 items of four HAQ versions: the HAQ-Disability scale, HAQ-II, modified HAQ and multi-dimensional HAQ (MD-HAQ)...
August 9, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28883652/tracking-the-tumor-invasion-front-using-long-term-fluidic-tumoroid-culture
#5
Koh Meng Aw Yong, Zida Li, Sofia D Merajver, Jianping Fu
The analysis of invading leader cells at the tumor invasion front is of significant interest as these cells may possess a coordinated functional and molecular phenotype which can be targeted for therapy. However, such analyses are currently limited by available technologies. Here, we report a fluidic device for long-term three-dimensional tumoroid culture which recapitulated the tumor invasion front, allowing for both quantification of invasive potential and molecular characterization of invasive leader cells...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882430/reproductive-outcomes-in-recipients-are-not-associated-with-oocyte-donor-body-mass-index-up-to-28%C3%A2-kg-m-2-a-cohort-study-of-2722-cycles
#6
Francisca Martínez, Alejandro Kava-Braverman, Elisabet Clúa, Ignacio Rodríguez, Sofia Gaggiotti Marre, Buenaventura Coroleu, Pedro N Barri
The effect of increasing donor body mass index (BMI) on clinical pregnancies was retrospectively analysed in a cohort of consecutive 2722 donor oocyte IVF cycles. The relationship between donor BMI and clinical pregnancies was assessed after adjusting for recipient BMI. Clinical pregnancy rates and live birth rates (LBR) were no different with increasing donor BMI (up to donor BMI ≤28 kg/m(2)). The odds of pregnancy did not vary with donor BMI. Compared with donor BMI quartile 1, OR 95% CI of clinical pregnancy was 1...
August 15, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28876352/nanostructured-interfacial-self-assembled-peptide-polymer-membranes-for-enhanced-mineralization-and-cell-adhesion
#7
Sofia Ribeiro, Elham Radvar, Yejiao Shi, João Borges, Rogério P Pirraco, Isabel B Leonor, João F Mano, Rui L Reis, Álvaro Mata, Helena S Azevedo
Soft interfacial materials, such as self-assembled polymer membranes, are gaining increasing interest as biomaterials since they can provide selective barriers and/or controlled affinity interactions important to regulate cellular processes. Herein, we report the design and fabrication of multiscale structured membranes integrating selective molecular functionalities for potential applications in bone regeneration. The membranes were obtained by interfacial self-assembly of miscible aqueous solutions of hyaluronan and multi-domain peptides (MDPs) incorporating distinct biochemical motifs, including mineralizing (EE), integrin-binding (RGDS) and osteogenic (YGFGG) peptide sequences...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28869658/understanding-life-experiences-of-people-affected-by-crohn-s-disease-in-spain-a-phenomenological-approach
#8
Sofía García-Sanjuán, Manuel Lillo-Crespo, Miguel Richart-Martínez, Ángela Sanjuán Quiles
BACKGROUND AND OBJECTIVES: People affected by Crohn's disease must adapt their lives to their new chronic condition, and therefore, understanding such experience can be helpful in planning effective interventions for the affected ones. The aim of this study was to gain an insight into such experience and how they adapted in different areas of their lives, particularly in a family-centred culture such as the Spanish one. METHOD: A descriptive phenomenological study was conducted through in-depth interviews to 19 people diagnosed of Crohn's disease in the province of Alicante (Spain)...
September 4, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28867298/transcriptional-and-epigenetic-analyses-of-the-dmd-locus-reveal-novel-cis%C3%A2-acting-dna-elements-that-govern-muscle-dystrophin-expression
#9
Samuele Gherardi, Matteo Bovolenta, Chiara Passarelli, Maria Sofia Falzarano, Paolo Pigini, Chiara Scotton, Marcella Neri, Annarita Armaroli, Hana Osman, Rita Selvatici, Francesca Gualandi, Alessandra Recchia, Marina Mora, Pia Bernasconi, Lorenzo Maggi, Lucia Morandi, Alessandra Ferlini, Giovanni Perini
The dystrophin gene (DMD) is the largest gene in the human genome, mapping on the Xp21 chromosome locus. It spans 2.2Mb and accounts for approximately 0,1% of the entire human genome. Mutations in this gene cause Duchenne and Becker Muscular Dystrophy, X-linked Dilated Cardiomyopathy, and other milder muscle phenotypes. Beside the remarkable number of reports describing dystrophin gene expression and the pathogenic consequences of the gene mutations in dystrophinopathies, the full scenario of the DMD transcription dynamics remains however, poorly understood...
August 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28855160/education-and-coronary-heart-disease-mendelian-randomisation-study
#10
Taavi Tillmann, Julien Vaucher, Aysu Okbay, Hynek Pikhart, Anne Peasey, Ruzena Kubinova, Andrzej Pajak, Abdonas Tamosiunas, Sofia Malyutina, Fernando Pires Hartwig, Krista Fischer, Giovanni Veronesi, Tom Palmer, Jack Bowden, George Davey Smith, Martin Bobak, Michael V Holmes
Objective To determine whether educational attainment is a causal risk factor in the development of coronary heart disease.Design Mendelian randomisation study, using genetic data as proxies for education to minimise confounding.Setting The main analysis used genetic data from two large consortia (CARDIoGRAMplusC4D and SSGAC), comprising 112 studies from predominantly high income countries. Findings from mendelian randomisation analyses were then compared against results from traditional observational studies (164 170 participants)...
August 30, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28817335/killed-by-police-validity-of-media-based-data-and-misclassification-of-death-certificates-in-massachusetts-2004-2016
#11
Justin M Feldman, Sofia Gruskin, Brent A Coull, Nancy Krieger
OBJECTIVES: To assess the validity of demographic data reported in news media-based data sets for persons killed by police in Massachusetts (2004-2016) and to evaluate misclassification of these deaths in vital statistics mortality data. METHODS: We identified 84 deaths resulting from police intervention in 4 news media-based data sources (WGBH News, Fatal Encounters, The Guardian, and The Washington Post) and, via record linkage, conducted matched-pair analyses with the Massachusetts mortality data...
October 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28813530/urban-and-peri-urban-family-based-pig-keeping-in-cambodia-characteristics-management-and-perceived-benefits-and-constraints
#12
Gunilla Ström, Agnes Andersson Djurfeldt, Sofia Boqvist, Ann Albihn, Seng Sokerya, Sorn San, Holl Davun, Ulf Magnusson
Keeping pigs in urban and peri-urban areas may not only provide many benefits for the urban households, but may also be challenging and a potential health hazard. The aim of this cross-sectional study was to describe household characteristics and to evaluate perceived benefits and constraints among pig-keepers in the urban and peri-urban areas of Phnom Penh, Cambodia. The study included 204 households and a structured questionnaire was used to interview the household member responsible for taking care of the pigs...
2017: PloS One
https://www.readbyqxmd.com/read/28813010/characterization-of-breakfast-cereals-available-in-the-mexican-market-sodium-and-sugar-content
#13
Claudia Nieto, Sofia Rincon-Gallardo Patiño, Lizbeth Tolentino-Mayo, Angela Carriedo, Simón Barquera
Preschool Mexican children consume 7% of their total energy intake from processed breakfast cereals. This study characterized the nutritional quality and labelling (claims and Guideline Daily Amount (GDA)) of the packaged breakfast cereals available in the Mexican market. Photographs of all breakfast cereals available in the 9 main food retail chains in the country were taken. The nutrition quality of cereals was assessed using the United Kingdom Nutrient Profiling Model (UKNPM). Claims were classified using the International Network for Food and Obesity/non-communicable Diseases Research, Monitoring and Action Support (INFORMAS) taxonomy and the GDA was defined according to the Mexican regulation, NOM-051...
August 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28811152/how-does-media-coverage-effect-the-consumption-of-antidepressants-a-study-of-the-media-coverage-of-antidepressants-in-danish-online-newspapers-2010-2011
#14
Michael Green Lauridsen, Sofia Kälvemark Sporrong
BACKGROUND: The news media has become a major source of health information for the public, and hence vital in the individuals' opinions and decisions about health topics. The first decrease in the usage of antidepressants in Denmark in over a decade happened alongside an intensive period of media coverage about antidepressants. OBJECTIVES: The aim of this study was to examine the Danish media's coverage of antidepressants during 2010-2011 in order to explore what influence it could have had on the change in the use of antidepressants...
August 2, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28810850/variations-in-diabetes-remission-rates-after-bariatric-surgery-in-spanish-adults-according-to-the-use-of-different-diagnostic-criteria-for-diabetes
#15
María R Alhambra-Expósito, María J Molina-Puerta, María I Prior-Sánchez, Gregorio Manzano-García, Alfonso Calañas-Continente, María A Gálvez-Moreno
BACKGROUND: There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remission after bariatric surgery: Criteria from Spanish scientific associations (SEEN/SEEDO/SED) and from the American Diabetes Association (ADA). We also aim to analyse the degree of correlation between these sets of criteria. METHODS: Retrospective observational study in 127 patients undergoing bariatric surgery in a single centre (Hospital Universitario Reina Sofía, Córdoba, Spain) between January 2001 and December 2009...
August 15, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28803581/nutrition-facts-panel-use-is-associated-with-diet-quality-and-dietary-patterns-among-latinos-with-type-2-diabetes
#16
Grace Kollannoor-Samuel, Sofia Segura-Pérez, Fatma M Shebl, Nicola L Hawley, Grace Damio, Jyoti Chhabra, Sonia Vega-López, Maria Luz Fernandez, Rafael Pérez-Escamilla
OBJECTIVE: The study aims were to (i) identify determinants of Nutrition Facts Panel (NFP) use and (ii) describe the association between NFP use and dietary intake among Latinos with type 2 diabetes. DESIGN: Baseline cross-sectional data from a clinical trial were used to assess the association between NFP use and dietary intake. Diet was measured using two methods: (i) a diet quality score (the Healthy Eating Index-2010) derived from a single 24 h recall and (ii) dietary pattern (exploratory factor analyses) from an FFQ...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28789982/mycobacterium-tuberculosis-genotypes-and-predominant-clones-among-the-multidrug-resistant-isolates-in-spain-1998-2005
#17
Sofía Samper, Patricia Gavín, María Isabel Millán-Lou, María José Iglesias, María Soledad Jiménez, David Couvin, Nalin Rastogi
Although the incidence of tuberculosis (TB) is gradually decreasing in Spain, there is an increase in the proportion of foreign-born cases. This changing scenario is slowly shifting the local TB epidemiology from endemic to imported cases with an increased risk for multidrug-resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis complex. MDR/XDR strains from Spain (n=366 MTBC isolates, 1 strain per patient) isolated between 1998 and 2005 were retained for this retrospective analysis...
August 5, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28781066/midwives-experiences-of-participating-in-a-midwifery-research-project-a-qualitative-study
#18
Susanne Åhlund, Sofia Zwedberg, Ingegerd Hildingsson, Malin Edqvist, Helena Lindgren
PROBLEM AND BACKGROUND: In an earlier research project midwives were asked to perform women-centered care focusing on the assumption that the physiological process in the second stage of labour could be trusted and that the midwives role should be encouraging and supportive rather than instructing. There is no knowledge about how midwives participating in such a research project, uses their skills and experience from the study in their daily work. AIM: The aim in this study was to investigate how midwives experienced implementing woman-centered care during second stage of labour...
August 3, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28746862/generation-of-monoclonal-antibodies-and-development-of-an-immunofluorometric-assay-for-the-detection-of-cuzd1-in-tissues-and-biological-fluids
#19
Sofia Farkona, Antoninus Soosaipillai, Panagiota Filippou, Dimitrios Korbakis, Stefano Serra, Felix Rückert, Eleftherios P Diamandis, Ivan M Blasutig
BACKGROUND: CUB and zona pellucida-like domain-containing protein 1 (CUZD1) was identified as a pancreas-specific protein and was proposed as a candidate biomarker for pancreatic related disorders. CUZD1 protein levels in tissues and biological fluids have not been extensively examined. The purpose of the present study was to generate specific antibodies targeting CUZD1 to assess CUZD1 expression within tissues and biological fluids. METHODS: Mouse monoclonal antibodies against CUZD1 were generated and used to perform immunohistochemical analyses and to develop a sensitive and specific enzyme-linked immunosorbent assay (ELISA)...
July 23, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28723901/2b-rad-genotyping-for-population-genomic-studies-of-chagas-disease-vectors-rhodnius-ecuadoriensis-in-ecuador
#20
Luis E Hernandez-Castro, Marta Paterno, Anita G Villacís, Björn Andersson, Jaime A Costales, Michele De Noia, Sofía Ocaña-Mayorga, Cesar A Yumiseva, Mario J Grijalva, Martin S Llewellyn
BACKGROUND: Rhodnius ecuadoriensis is the main triatomine vector of Chagas disease, American trypanosomiasis, in Southern Ecuador and Northern Peru. Genomic approaches and next generation sequencing technologies have become powerful tools for investigating population diversity and structure which is a key consideration for vector control. Here we assess the effectiveness of three different 2b restriction site-associated DNA (2b-RAD) genotyping strategies in R. ecuadoriensis to provide sufficient genomic resolution to tease apart microevolutionary processes and undertake some pilot population genomic analyses...
July 2017: PLoS Neglected Tropical Diseases
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