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JOURNAL ARTICLE
Laura Ferguson, Sarah Emoto, Sofia Gruskin
Access to sexual health services and information is critical to achieving the highest attainable standard of sexual health, and enabling legal environments are key to advancing progress in this area. In determining overall alignment with human rights standards to respect, protect, and fulfil sexual health-related rights without discrimination, there are many aspects of laws, including their specificity and content, which impact which sexual health services and information are availed, which are restricted, and for whom...
December 2024: Sexual and reproductive health matters
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JOURNAL ARTICLE
David Hodson, Hitesh Mistry, James Yates, Sofia Guzzetti, Michael Davies, Leon Aarons, Kayode Ogungbenro
BACKGROUND: Preclinical models of cancer can be of translational benefit when assessing how different biomarkers are regulated in response to particular treatments. Detection of molecular biomarkers in preclinical models of cancer is difficult due inter-animal variability in responses, combined with limited accessibility of longitudinal data. METHODS: Nonlinear mixed-effects modelling (NLME) was used to analyse tumour growth data based on expected tumour growth rates observed 7 days after initial doses (DD7) of Radiotherapy (RT) and Combination of RT with DNA Damage Response Inhibitors (DDRi)...
April 17, 2024: European Journal of Pharmaceutical Sciences
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JOURNAL ARTICLE
Laia Peruchet-Noray, Anja M Sedlmeier, Niki Dimou, Hansjörg Baurecht, Béatrice Fervers, Emma Fontvieille, Julian Konzok, Kostas K Tsilidis, Sofia Christakoudi, Anna Jansana, Reynalda Cordova, Patricia Bohmann, Michael J Stein, Andrea Weber, Stéphane Bézieau, Hermann Brenner, Andrew T Chan, Iona Cheng, Jane C Figueiredo, Koldo Garcia-Etxebarria, Victor Moreno, Christina C Newton, Stephanie L Schmit, Mingyang Song, Cornelia M Ulrich, Pietro Ferrari, Vivian Viallon, Robert Carreras-Torres, Marc J Gunter, Heinz Freisling
It remains unknown whether adiposity subtypes are differentially associated with colorectal cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi-trait body shape phenotypes reflecting adiposity subtypes from principal components analysis on body mass index, height, weight, waist-to-hip ratio, and waist and hip circumference. A generally obese (PC1) and a tall, centrally obese (PC3) body shape were both positively associated with CRC risk in observational analyses in 329,828 UK Biobank participants (3728 cases)...
April 19, 2024: Science Advances
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JOURNAL ARTICLE
Inês Ribeiro, Sofia Correia, Martina Blümel, Pedro Albuquerque, Stanislav N Gorb, Marta V Mendes, Deniz Tasdemir, Ana P Mucha, Maria F Carvalho
A novel strain, MA3_2.13T , was isolated from deep-sea sediment of Madeira Archipelago, Portugal, and characterized using a polyphasic approach. This strain produced dark brown soluble pigments, bronwish black substrate mycelia and an aerial mycelium with yellowish white spores, when grown on GYM 50SW agar. The main respiratory quinones were MK-10(H4 ), MK-10(H6 ) and MK-10(H8 ). Diphosphatidylglycerol, phosphatidylethanolamine, three unidentified phospholipids and two glycophospholipids were identified as the main phospholipids...
April 2024: International Journal of Systematic and Evolutionary Microbiology
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JOURNAL ARTICLE
Sofía Schwartz-Salazar, Efraín García-Sánchez, Rocío Martínez, Rosa Rodríguez-Bailón
Perceptions of gender inequality may motivate people to take action against inequality given its negative impact on various domains of people's everyday lives. Thus, it is crucial to develop reliable measures that consider the multidimensional nature of gender inequalities. In this research, we propose and assess the psychometric properties of the Multidimensional Gender Inequality Perception Scale (MuGIPS). This is a self-reported measure of perceived gender inequality in four domains: health, violence, household work and caregiving, and public sphere and power...
2024: PloS One
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JOURNAL ARTICLE
Sofia K Drakopoulou, Stefanos E Kokolakis, Apostolos L Karagiannidis, Marilena E Dasenaki, Niki C Maragou, Nikolaos S Thomaidis
This study presents the development and validation of a comprehensive high-resolution mass spectrometry (HRMS) methodology for the detection of 771 pesticides in olive oil, using liquid chromatography with electrospray ionization, operating in positive and negative mode, and gas chromatography with atmospheric-pressure chemical ionization in positive mode, both coupled to quadrupole-time-of-flight mass spectrometry (LC-(ESI)-/GC-(APCI)-QTOF MS). Special reference is made to the post-acquisition evaluation step, in which all LC/GC-HRMS analytical evidence ( i...
April 16, 2024: Analytical Methods: Advancing Methods and Applications
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JOURNAL ARTICLE
Dionysis Nikolopoulos, Catherine Loukogiannaki, George Sentis, Panagiotis Garantziotis, Theodora Manolakou, Noemin Kapsala, Myrto Nikoloudaki, Antigone Pieta, Sofia Flouda, Ioannis Parodis, George Bertsias, Antonis Fanouriakis, Anastasia Filia, Dimitrios T Boumpas
INTRODUCTION: Systemic lupus erythematosus with antiphospholipid syndrome (SLE-APS) represents a challenging SLE endotype whose molecular basis remains unknown. METHODS: We analysed whole-blood RNA-sequencing data from 299 patients with SLE (108 SLE-antiphospholipid antibodies (aPL)-positive, including 67 SLE-APS; 191 SLE-aPL-negative) and 72 matched healthy controls (HC). Pathway enrichment analysis, unsupervised weighted gene coexpression network analysis and machine learning were applied to distinguish disease endotypes...
April 12, 2024: Annals of the Rheumatic Diseases
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JOURNAL ARTICLE
Jose Antonio Urigüen, Sofía Ruiz de Gauna, Jose Julio Gutiérrez, Izaskun Azcárate, Mikel Leturiondo, Koldo Redondo, James Knox Russell, Mohamud Ramzan Daya
AIM: Propose new metrics of impulsiveness of manual chest compressions (CCs) that account for shape and duration, separate the characteristics of the compressive part of the CC cycle from those of the recoil part, and are uncorrelated to CC depth and rate. METHODS: We conducted a retrospective analysis of adult out-of-hospital cardiac arrest monitor-defibrillator recordings having CPR data. Specifically, episodes of adult patients with ≥ 1000 compressions free of leaning were examined...
April 15, 2024: Heliyon
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REVIEW
Filipa Fernandes, Sofia Oliveira, Francisca Monteiro, Michael Gasik, Filipe S Silva, Nuno Sousa, Óscar Carvalho, Susana O Catarino
A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical and cadaveric approaches, in which light stimuli were applied to the head and/or neck. PubMed, Scopus, Web of Science and Google Scholar databases were used for the systematic search. A total of 2133 records were screened, from which 97 were included in this review. The parameters that were extracted and analysed in each article were the device design, actuation area, actuation site, wavelength, mode of operation, power density, energy density, power output, energy per session and treatment time...
April 10, 2024: Journal of Neuroengineering and Rehabilitation
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JOURNAL ARTICLE
Petros Zamout, Sofia Exarchou, Ankita Sharma, Carl Turesson
Spondyloarthritis (SpA) has been associated with comorbidities, e.g., cardiovascular disease. However, little is known about the relation between SpA and chronic obstructive pulmonary disease (COPD). The aim of the study was to compare the prevalence of COPD in SpA to the general population. Patients with prevalent SpA in Skåne, Sweden, on December 31, 2018, were identified based on diagnostic codes in a regional register on primary care, secondary outpatient care and inpatient care. Population-based controls (5 per SpA case) were matched for age, sex and municipality...
April 10, 2024: Clinical and Experimental Medicine
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JOURNAL ARTICLE
Sofia C Orellana, Richard A I Bethlehem, Ivan L Simpson-Kent, Anne-Laura van Harmelen, Petra E Vértes, Edward T Bullmore
Childhood maltreatment (CM) leads to a lifelong susceptibility to mental ill-health which might be reflected by its effects on adult brain structure, perhaps indirectly mediated by its effects on adult metabolic, immune, and psychosocial systems. Indexing these systemic factors via body mass index (BMI), C-reactive protein (CRP), and rates of adult trauma (AT), respectively, we tested three hypotheses: (H1) CM has direct or indirect effects on adult trauma, BMI, and CRP; (H2) adult trauma, BMI, and CRP are all independently related to adult brain structure; and (H3) childhood maltreatment has indirect effects on adult brain structure mediated in parallel by BMI, CRP, and AT...
April 16, 2024: Proceedings of the National Academy of Sciences of the United States of America
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JOURNAL ARTICLE
Sofia Perez Otero, Allison L Diaz, Kshipra Hemal, Carter J Boyd, Wen-Yu Lee, Nolan S Karp
PURPOSE: Merit-based incentive payment system (MIPS) is a payment model implemented to promote high-value care through performance-based adjustments of Medicare reimbursements. Higher scores indicate superior performance in healthcare quality, efficiency, and interoperability, which can result in financial advantages. Given the paucity of literature, we aimed to characterize plastic surgery performance in MIPS. METHOD: The Centers for Medicare and Medicaid Services (CMS) online data repository was queried for data on MIPS performance of plastic surgeons from 2019-2021...
April 9, 2024: Plastic and Reconstructive Surgery
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JOURNAL ARTICLE
Maria Sofia Bertilacchi, Rebecca Piccarducci, Alessandro Celi, Lorenzo Germelli, Chiara Romei, Brian Bartholmai, Greta Barbieri, Chiara Giacomelli, Claudia Martini
BACKGROUND: COVID-19 reduces lung functionality causing a decrease of blood oxygen levels (hypoxemia) often related to a decreased cellular oxygenation (hypoxia). Besides lung injury, other factors are implicated in the regulation of oxygen availability such as pH, partial arterial carbon dioxide tension (PaCO2 ), temperature, and erythrocytic 2,3-bisphosphoglycerate (2,3-BPG) levels, all factors affecting hemoglobin saturation curve. However, few data are currently available regarding the 2,3-BPG modulation in SARS-CoV-2 affected patients at the hospital admission...
April 5, 2024: Biomedical Journal
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JOURNAL ARTICLE
Andrea C Tricco, Amanda Parker, Paul A Khan, Vera Nincic, Reid Robson, Heather MacDonald, Rachel Warren, Olga Cleary, Elaine Zibrowski, Nancy Baxter, Karen E A Burns, Doug Coyle, Ruth Ndjaboue, Jocalyn P Clark, Etienne V Langlois, Sofia B Ahmed, Holly O Witteman, Ian D Graham, Wafa El-Adhami, Becky Skidmore, France Légaré, Janet Curran, Gillian Hawker, Jennifer Watt, Ivy Lynn Bourgeault, Jeanna Parsons Leigh, Karen Lawford, Alice Aiken, Christopher McCabe, Sasha Shepperd, Reena Pattani, Natalie Leon, Jamie Lundine, Évèhouénou Lionel Adisso, Santa Ono, Linda Rabeneck, Sharon E Straus
BACKGROUND: Various studies have demonstrated gender disparities in workplace settings and the need for further intervention. This study identifies and examines evidence from randomized controlled trials (RCTs) on interventions examining gender equity in workplace or volunteer settings. An additional aim was to determine whether interventions considered intersection of gender and other variables, including PROGRESS-Plus equity variables (e.g., race/ethnicity). METHODS: Scoping review conducted using the JBI guide...
April 5, 2024: BMC Medicine
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JOURNAL ARTICLE
Chantal L Rytz, Keila Turino Miranda, Paul E Ronksley, Nathalie Saad, Satish R Raj, Ranjani Somayaji, Sandra M Dumanski, Heather Ganshorn, Dina N Greene, David Collister, Amelia M Newbert, Lindsay Peace, Sofia B Ahmed
INTRODUCTION: Gender-affirming estrogen therapy (GAET) is commonly used for feminization in transgender and non-binary (TNB) individuals, yet the optimal rate of change (ROC) in estradiol levels for cardiovascular health is unclear. We examined the association between serum estradiol levels and cardiovascular-related mortality, adverse events, and risk factors in TNB adults using GAET. METHODS: Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE and Web of Science were systematically searched (inception-April 2023) for original articles reporting serum estradiol levels and cardiovascular-related mortality, adverse events, and risk factors in TNB adults using GAET...
April 5, 2024: American Journal of Physiology. Heart and Circulatory Physiology
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JOURNAL ARTICLE
Lindsay A Williams, Sofia Barragan, Zhanni Lu, Brenda J Weigel, Logan G Spector
BACKGROUND: Osteosarcoma displays a bimodal peak in incidence in adolescence and later adulthood. Males are more frequently diagnosed with osteosarcoma in both periods. Males have worse survival than females, which is generally poor at 30-70% 5-years post diagnosis, depending on age, but treatment received is often unaccounted for in survival analyses. METHODS: Therefore, we estimated sex differences in survival for children and adults stratifying by treatment received and other disease characteristics using the National Cancer Database (2004-2016, n=9017)...
April 3, 2024: Cancer Epidemiology
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JOURNAL ARTICLE
Adrian Scutelnic, Anita van de Munckhof, Angel T Miraclin, Sanjith Aaron, Sajid Hameed, Mohammad Wasay, Oxana Grosu, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Tiago Moreira, Roberto Acampora, Alberto Negro, Theodoros Karapanayiotides, Shadi Yaghi, Anna Revert, Elisa Cuadrado Godia, Sebastian Garcia-Madrona, Paolino La Spina, Francesco Grillo, Fabrizio Giammello, Thanh N Nguyen, Mohamad Abdalkader, Alina Buture, Maria Sofia Cotelli, Nicolas Raposo, Georgios Tsivgoulis, Paolo Candelaresi, Antonio Ciacciarelli, Joshua Mbroh, Tatiana Batenkova, Pasquale Scoppettuolo, Marialuisa Zedde, Rosario Pascarella, Kateryna Antonenko, Espen S Kristoffersen, Johanna A Kremer Hovinga, Katarina Jood, Diana Aguiar de Sousa, Sven Poli, Turgut Tatlisumak, Jukka Putaala, Jonathan M Coutinho, José M Ferro, Marcel Arnold, Mirjam R Heldner
INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison...
April 4, 2024: European Stroke Journal
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JOURNAL ARTICLE
Vincenza Gianfredi, Lorenzo Stacchini, Sofia Lotti, Iris Sarno, Francesco Sofi, Monica Dinu
Sustainability is crucial for transforming the food system, addressing environmental and nutrition issues and depends on consumer perceptions and values. This cross-sectional study investigates the relationship between sustainability attitudes, knowledge, and eating behaviours. Nearly half reported high level of knowledge regarding food sustainability while 24% expressed high attitude towards food sustainability. Women reported higher levels of knowledge and attitude towards food sustainability. Logistic regression analyses, adjusted for age, sex, and education, revealed that using public transport, biking, or walking was significantly associated with higher odds of having a more positive overall attitude towards food sustainability (OR = 1...
April 4, 2024: International Journal of Food Sciences and Nutrition
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JOURNAL ARTICLE
Jesem Douglas Yamall Orellana, Daniel Gray Paschoal Leventhal, María Del Pilar Flores-Quispe, Lihsieh Marrero, Nadège Jacques, Lina Sofía Morón-Duarte, Cynthia Boschi-Pinto
BACKGROUND: Accurate estimates of the COVID-19 pandemic's indirect impacts are crucial, especially in low- and middle-income countries. This study aims to update estimates of excess maternal deaths in Brazil during the first two years of the COVID-19 pandemic. METHODS: This was an exploratory mixed ecological study using the counterfactual approach. The observed maternal deaths were gathered from the Mortality Information System (SIM) for the period between March 2015 and February 2022...
2024: PloS One
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JOURNAL ARTICLE
Ana Maite Folle, Sofía Lagos Magallanes, Martín Fló, Romina Alvez-Rosado, Federico Carrión, Cecilia Vallejo, David Watson, Josep Julve, Gualberto González-Sapienza, Otto Pristch, Andrés González-Techera, Ana María Ferreira
Cestodes use own lipid-binding proteins to capture and transport hydrophobic ligands, including lipids that they cannot synthesise as fatty acids and cholesterol. In E. granulosus s.l., one of these lipoproteins is antigen B (EgAgB), codified by a multigenic and polymorphic family that gives rise to five gene products (EgAgB8/1-5 subunits) assembled as a 230 kDa macromolecule. EgAgB has a diagnostic value for cystic echinococcosis, but its putative role in the immunobiology of this infection is still poorly understood...
2024: Frontiers in Cellular and Infection Microbiology
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