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Rabbit haemorrhagic disease

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https://www.readbyqxmd.com/read/28935204/the-taishan-robinia-pseudoacacia-polysaccharides-enhance-immune-effects-of-rabbit-haemorrhagic-disease-virus-inactivated-vaccines
#1
Shifa Yang, Guiming Li, Zengcheng Zhao, Minyan Feng, Jian Fu, Zhongli Huang, Minxun Song, Shuqian Lin
Robinia pseudoacacia flower, a common component in traditional Chinese medicine, has long been well-known for its high pharmaceutical value. This study aimed to assess the immunopotentiating effects of Taishan Robinia Pseudoacacia polysaccharides (TRPPS) in rabbits inoculated with a rabbit haemorrhagic disease virus (RHDV) inactivated vaccine. The rabbits were administered with the RHDV vaccine in conjunction with varying concentrations of TRPPS, and their blood samples were collected at different time points to analyze the ratio and number of blood lymphocytes...
September 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28815049/multi-target-chimaeric-vlp-as-a-therapeutic-vaccine-in-a-model-of-colorectal-cancer
#2
Braeden Donaldson, Farah Al-Barwani, Simon J Pelham, Katie Young, Vernon K Ward, Sarah L Young
BACKGROUND: Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination is a promising alternative to conventional treatment for colorectal cancer, using vaccines to induce targeted immune responses against tumour-associated antigens. In this study, we have developed chimaeric virus-like particles (VLP), a form of non-infectious non-replicative subunit vaccine consisting of rabbit haemorrhagic disease virus (RHDV) VP60 capsid proteins containing recombinantly inserted epitopes from murine topoisomerase IIα and survivin...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28806910/multi-target-chimaeric-vlp-as-a-therapeutic-vaccine-in-a-model-of-colorectal-cancer
#3
Braeden Donaldson, Farah Al-Barwani, Simon J Pelham, Katie Young, Vernon K Ward, Sarah L Young
BACKGROUND: Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination is a promising alternative to conventional treatment for colorectal cancer, using vaccines to induce targeted immune responses against tumour-associated antigens. In this study, we have developed chimaeric virus-like particles (VLP), a form of non-infectious non-replicative subunit vaccine consisting of rabbit haemorrhagic disease virus (RHDV) VP60 capsid proteins containing recombinantly inserted epitopes from murine topoisomerase IIα and survivin...
August 15, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28763035/a-motif-in-the-f-homomorph-of-rabbit-haemorrhagic-disease-virus-polymerase-is-important-for-the-subcellular-localisation-of-the-protein-and-its-ability-to-induce-redistribution-of-golgi-membranes
#4
Nadya Urakova, Andrew C Warden, Peter A White, Tanja Strive, Michael Frese
Rabbit haemorrhagic disease virus (RHDV) is a calicivirus that infects and frequently kills rabbits. Previously, we showed that the RHDV RNA-dependent RNA polymerase (RdRp) is associated with distinct, but yet uncharacterised subcellular structures and is capable of inducing a redistribution of Golgi membranes. In this study, we identified a partially hidden hydrophobic motif that determines the subcellular localisation of recombinant RHDV RdRp in transfected cells. This novel motif, 189LLWGCDVGVAVCAAAVFHNICY210, is located within the F homomorph, between the conserved F3 and A motifs of the core RdRp domain...
August 1, 2017: Viruses
https://www.readbyqxmd.com/read/28743597/adaptive-diversification-between-the-classic-rabbit-hemorrhagic-disease-virus-rhdv-and-the-rhdva-isolates-a-genome-wide-perspective
#5
Yan Li, Xueping Yao, Ying Li, Feifei Xu, Zexiao Yang
Rabbit haemorrhagic disease virus (RHDV) is a highly infectious pathogen that causes high mortality in wild and domestic rabbits. RHDV could be divided into two subtypes, classic RHDV and RHDVa, which present clear genetic, antigenic, and epidemiological differences. To further understand the nature of the diversity, we performed a genome-wide evolutionary study on the classic RHDV and RHDVa isolates. The results show that RHDV had experienced adaptive diversification with the dividing process of these subtypes...
July 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28714849/proposal-for-a-unified-classification-system-and-nomenclature-of-lagoviruses
#6
Jacques Le Pendu, Joana Abrantes, Stéphane Bertagnoli, Jean-Sébastien Guitton, Ghislaine Le Gall-Reculé, Ana Margarida Lopes, Stéphane Marchandeau, Fernando Alda, Tereza Almeida, Alves Paulo Célio, Juan Bárcena, Galina Burmakina, Esther Blanco, Carlos Calvete, Patrizia Cavadini, Brian Cooke, Kevin Dalton, Miguel Delibes Mateos, Wieslaw Deptula, John Sebastian Eden, Fang Wang, Catarina C Ferreira, Paula Ferreira, Pilar Foronda, David Gonçalves, Dolores Gavier-Widén, Robin Hall, Beata Hukowska-Szematowicz, Peter Kerr, John Kovaliski, Antonio Lavazza, Jackie Mahar, Alexander Malogolovkin, Raquel M Marques, Sara Marques, Aaron Martin-Alonso, Pedro Monterroso, Sacramento Moreno, Greg Mutze, Aleksija Neimanis, Paulina Niedzwiedzka-Rystwej, David Peacock, Francisco Parra, Mara Rocchi, Carlos Rouco, Nathalie Ruvoën-Clouet, Eliane Silva, Diogo Silvério, Tanja Strive, Gertrudes Thompson, Beata Tokarz-Deptula, Pedro Esteves
Lagoviruses belong to the Caliciviridae family. They were first recognized as highly pathogenic viruses of the European rabbit (Oryctolagus cuniculus) and European brown hare (Lepus europaeus) that emerged in the 1970-1980s, namely, rabbit haemorrhagic disease virus (RHDV) and European brown hare syndrome virus (EBHSV), according to the host species from which they had been first detected. However, the diversity of lagoviruses has recently expanded to include new related viruses with varying pathogenicity, geographic distribution and host ranges...
July 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28702932/phylogenetic-analysis-of-rabbit-haemorrhagic-disease-virus-rhdv-strains-isolated-in-poland
#7
Andrzej Fitzner, Wieslaw Niedbalski
The aim of this study was to characterise the nucleotide and amino acid sequence of complete genomes (7.5 kb) from RHDV strains isolated in Poland and estimate the genetic variability in different elements of the viral RNA. In addition, the sequence of Polish RHDV isolates isolated from 1988-2015 was compared with the sequences of other European RHDV, including the RHDVa and RHDV2/RHDVb subtypes. The complete sequence was developed by the compilation of partial nucleotide sequences. This sequence consisted of approximately 7428 nucleotides...
July 12, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28689774/expression-of-il-1ra-il-6-il-8-il-18-tnf-%C3%AE-and-ifn-%C3%AE-genes-in-peripheral-blood-leukocytes-of-rabbits-infected-with-rhdv-rabbit-haemorrhagic-disease-virus
#8
Alicja Trzeciak-Ryczek, Beata Tokarz-Deptuła, Wiesław Deptuła
Rabbit haemorrhagic disease virus (RHDV) induces a highly contagious and extremely lethal disease that fulfils many requirements of an animal model of fulminant hepatic failure (FHF); however, the pathogenesis of RHD has still not been fully elucidated. Cytokines play an important role in regulation of the immune response and pathogenesis of many diseases, including those caused by viral infections. Furthermore, recent studies indicate a role of the immune response, especially peripheral blood leukocytes (PBL), in the pathogenesis of RHD...
July 8, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28667769/resistance-to-rhd-virus-in-wild-australian-rabbits-comparison-of-susceptible-and-resistant-individuals-using-a-genomewide-approach
#9
Nina I Schwensow, Harald Detering, Stephen Pederson, Camila Mazzoni, Ron Sinclair, David Peacock, John Kovaliski, Brian Cooke, Jörns Fickel, Simone Sommer
Deciphering the genes involved in disease resistance is essential if we are to understand host-pathogen coevolutionary processes. The rabbit haemorrhagic disease virus (RHDV) was imported into Australia in 1995 as a biocontrol agent to manage one of the most successful and devastating invasive species, the European rabbit (Oryctolagus cuniculus). During the first outbreaks of the disease, RHDV caused mortality rates of up to 97%. Recently, however, increased genetic resistance to RHDV has been reported. Here, we have aimed to identify genomic differences between rabbits that survived a natural infection with RHDV and those that died in the field using a genomewide next-generation sequencing (NGS) approach...
July 1, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28653381/efficacy-of-a-commercial-vaccine-against-different-strains-of-rabbit-haemorrhagic-disease-virus
#10
A J Read, P D Kirkland
BACKGROUND: This study investigated the ability of a commercial rabbit haemorrhagic disease virus (RHDV) vaccine (Cylap®) to protect rabbits from disease caused by two different strains of the virus (v351 and K5) that are used or proposed to be used for wild rabbit control in Australia. These strains of the RHDV1 genotype belong to the 'classical RHDV' and 'antigenic variant RHDVa' subtypes, respectively. METHODS: Vaccinated rabbits were exposed to very high doses of the virus either by direct oral dosing or by exposure to infected rabbit livers...
July 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28639220/emergence-of-rabbit-haemorrhagic-disease-virus-2-in-the-archipelago-of-madeira-portugal-2016-2017
#11
Carina Luísa Carvalho, Sara Silva, Paz Gouveia, Margarida Costa, Elsa Leclerc Duarte, Ana Margarida Henriques, Sílvia Santos Barros, Tiago Luís, Fernanda Ramos, Teresa Fagulha, Miguel Fevereiro, Margarida Dias Duarte
We report the detection of rabbit haemorrhagic disease virus 2 (RHDV2) in the Madeira archipelago, Portugal. Viral circulation was confirmed by RT-qPCR and vp60 sequencing. Epidemiological data revealed the outbreak initiated in October 2016 in Porto Santo affecting wild and domestic rabbits. It was then detected three months later on the island of Madeira. Five haplotypes were identified and a genetic overall similarity of 99.54 to 99.89% was observed between the two viral populations. Unique single nucleotide polymorphisms were recognised in the Madeira archipelago strains, two of which resulting in amino acid substitutions at positions 480 and 570 in the VP60 protein...
June 21, 2017: Virus Genes
https://www.readbyqxmd.com/read/28426381/hyperbaric-oxygen-for-experimental-intracerebral-haemorrhage-systematic-review-and-stratified-meta-analysis
#12
Han-Jin Cui, Hao-Yu He, A-Li Yang, Hua-Jun Zhou, Tao Tang, Jie-Kun Luo
OBJECTIVE: Hyperbaric oxygen (HBO) is widely used in treating various neurological diseases. However, HBO for treatment of intracerebral haemorrhage (ICH) remains controversial, in either animal or clinical studies. Therefore, we conducted this systematic review and meta-analysis on studies describing the efficacy of HBO in animal models of ICH. METHODS: Studies were identified by searching mainstream databases through November 2015. The efficacy of HBO in animal models of ICH was assessed by changes in the brain water content (BWC), neurobehavioural outcome (NO) or both...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28407381/arrival-of-rabbit-haemorrhagic-disease-virus-2-to-northern-europe-emergence-and-outbreaks-in-wild-and-domestic-rabbits-oryctolagus-cuniculus-in-sweden
#13
A S Neimanis, H Ahola, S Zohari, U Larsson Pettersson, C Bröjer, L Capucci, D Gavier-Widén
Incursion of rabbit haemorrhagic disease virus (RHDV) into Sweden was documented in 1990 and it is now considered endemic in wild rabbit (Oryctolagus cuniculus) populations. Rabbit haemorrhagic disease virus 2 (RHDV2), a new, related lagovirus was first detected in France in 2010, and has spread rapidly throughout Europe and beyond. However, knowledge of RHDV2 in northern Europe is sporadic and incomplete, and in Sweden, routinely available diagnostic methods to detect rabbit haemorrhagic disease (RHD) do not distinguish between types of virus causing disease...
April 13, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28363968/benign-rabbit-calicivirus-in-new-zealand
#14
Leila J Nicholson, Jackie E Mahar, Tanja Strive, Tao Zheng, Edward C Holmes, Vernon K Ward, Janine A Duckworth
The Czech v351 strain of rabbit hemorrhagic disease virus (RHDV1) is used in Australia and New Zealand as a biological control agent for rabbits, which are important and damaging introduced vertebrate pests in these countries. However, nonpathogenic rabbit caliciviruses (RCVs) can provide partial immunological cross-protection against lethal RHDV infection and thus interfere with effective rabbit biocontrol. Antibodies that cross-reacted against RHDV antigens were found in wild rabbits before the release of RHDV1 in New Zealand in 1997, suggesting that nonpathogenic RCVs were already present in New Zealand...
June 1, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28341721/increased-pathogenicity-in-rabbit-haemorrhagic-disease-virus-type-2-rhdv2
#15
L Capucci, P Cavadini, M Schiavitto, G Lombardi, A Lavazza
No abstract text is available yet for this article.
March 24, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28288206/an-in-vivo-system-for-directed-experimental-evolution-of-rabbit-haemorrhagic-disease-virus
#16
Robyn N Hall, Lorenzo Capucci, Markus Matthaei, Simona Esposito, Peter J Kerr, Michael Frese, Tanja Strive
The calicivirus Rabbit haemorrhagic disease virus (RHDV) is widely used in Australia as a biocontrol agent to manage wild European rabbit (Oryctolagus cuniculus) populations. However, widespread herd immunity limits the effectiveness of the currently used strain, CAPM V-351. To overcome this, we developed an experimental platform for the selection and characterisation of novel RHDV strains. As RHDV does not replicate in cell culture, variant viruses were selected by serially passaging a highly virulent RHDV field isolate in immunologically naïve laboratory rabbits that were passively immunised 18-24 hours post-challenge with a neutralising monoclonal antibody...
2017: PloS One
https://www.readbyqxmd.com/read/28253375/genomic-and-phenotypic-characterization-of-myxoma-virus-from-great-britain-reveals-multiple-evolutionary-pathways-distinct-from-those-in-australia
#17
Peter J Kerr, Isabella M Cattadori, Matthew B Rogers, Adam Fitch, Adam Geber, June Liu, Derek G Sim, Brian Boag, John-Sebastian Eden, Elodie Ghedin, Andrew F Read, Edward C Holmes
The co-evolution of myxoma virus (MYXV) and the European rabbit occurred independently in Australia and Europe from different progenitor viruses. Although this is the canonical study of the evolution of virulence, whether the genomic and phenotypic outcomes of MYXV evolution in Europe mirror those observed in Australia is unknown. We addressed this question using viruses isolated in the United Kingdom early in the MYXV epizootic (1954-1955) and between 2008-2013. The later UK viruses fell into three distinct lineages indicative of a long period of separation and independent evolution...
March 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28092608/white-and-red-blood-cell-picture-in-rabbits-experimentally-infected-with-strains-of-the-rabbit-haemorrhagic-disease-rhd-virus-without-or-with-variable-haemagglutination-capacity
#18
P Niedźwiedzka-Rystwej, B Tokarz-Deptuła, W Deptuła
The aim of the study was to establish if haemagglutination of rabbit haemorrhagic disease virus (RHDV) affects haematological picture of peripheral blood in rabbits and the pathogenicity of the virus. The study analyzed white and red blood cell picture in rabbits experimentally infected with two non-haemagglutinating (HA-) RHDV strains (Frankfurt and Asturias) and one strain with variable haemagglutination capacity (HA+/-) (Hagenow). Studies with HA- and HA +/- are rare and relate only to 4 HA- strains (2 RHDV: BLA and Rainham; 2 RHDVa: Pv97 and 9905) and 1 HA+/- RHDV strain: ŻD, where less changes in haematological indices and less pathogenicity were observed...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28088341/evaluation-of-an-in-house-indirect-elisa-for-detection-of-antibody-against-haemorrhagic-septicemia-in-asian-elephants
#19
Pallop Tankaew, Thawatchai Singh-La, Chatchote Titaram, Veerasak Punyapornwittaya, Preeyanat Vongchan, Takuo Sawada, Nattawooti Sthitmatee
Pasteurella multocida causes haemorrhagic septicemia in livestock and wild animals, including elephants. The disease has been reported in Asian elephants in India and Sri Lanka, but to date there have been no reported cases in Thailand. ELISA or indirect hemagglutination assays (IHA) have been demonstrated to be able to detect the antibody against the disease in cattle, but no data are available for elephants. The present study reports a novel in-house indirect ELISA for antibody detection of haemorrhagic septicemia in Asian elephants, and evaluates the sensitivity and specificity of the method using a Bayesian approach...
March 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28072826/rna-dependent-rna-polymerases-of-both-virulent-and-benign-rabbit-caliciviruses-induce-striking-rearrangement-of-golgi-membranes
#20
Nadya Urakova, Tanja Strive, Michael Frese
The extremely pathogenic Rabbit haemorrhagic disease virus (RHDV) and the completely benign Rabbit calicivirus (RCV) are closely related members of the genus Lagovirus (family Caliciviridae). The molecular mechanisms that determine the dramatic difference in virulence are unknown, but indirect evidence suggests that different properties of their RNA-dependent RNA polymerases (RdRps) may at least partially be responsible for the contrasting phenotypes. Here we report that the unusual ability of the RHDV RdRp to induce a striking rearrangement of the Golgi network is not specific to RHDV, but a common feature of virulent and benign rabbit caliciviruses alike...
2017: PloS One
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