Rishabh C Choudhary, Cyrus E Kuschner, Jacob Kazmi, Liam Mcdevitt, Blanca B Espin, Mohammed Essaihi, Mitsuaki Nishikimi, Lance B Becker, Junhwan Kim
The human brain possesses three predominate phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS), which account for approximately 35-40%, 35-40%, and 20% of the brain's phospholipids, respectively. Mitochondrial membranes are relatively diverse, containing the aforementioned PC, PE, and PS, as well as phosphatidylinositol (PI) and phosphatidic acid (PA); however, cardiolipin (CL) and phosphatidylglycerol (PG) are exclusively present in mitochondrial membranes. These phospholipid interactions play an essential role in mitochondrial fusion and fission dynamics, leading to the maintenance of mitochondrial structural and signaling pathways...
April 24, 2024: International Journal of Molecular Sciences