keyword
MENU ▼
Read by QxMD icon Read
search

lysophospholipid

keyword
https://www.readbyqxmd.com/read/28506691/urinary-lysophopholipids-are-increased-in-diabetic-patients-with-nephropathy
#1
Jean-Sébastien Saulnier-Blache, Eva Feigerlova, Jean Michel Halimi, Pierre Gourdy, Ronan Roussel, Bruno Guerci, Aude Dupuy, Justine Bertrand-Michel, Jean-Loup Bascands, Samy Hadjadj, Joost P Schanstra
Diabetic nephropathy (DN) is a major cause of chronic kidney disease that frequently leads to end stage renal failure. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are lysophospholipid mediators shown to accumulate in kidney and to promote renal inflammation and tubulo-interstitial fibrosis in diabetic rodent models. Here we assessed whether LPA and LPC were associated to the development of nephropathy in diabetic human patients. Several molecular species of LPA and LPC were quantified by LC/MS-MS in urine and plasma from type 2 diabetic patients with (cases; n=41) or without (controls, n=41) nephropathy symptoms (micro/macro-albuminuria and eGFR<60ml/min/1...
May 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28506062/lc-ms-untargeted-metabolomics-to-explain-the-signal-metabolites-inducing-browning-in-fresh-cut-lettuce
#2
Carlos J García, Rocío García-Villalba, María I Gil, Francisco A Tomas-Barberan
Enzymatic browning is one of the main causes of quality loss in lettuce as a prepared and ready-to-eat cut salad. An untargeted metabolomics approach using UPLC-ESI-QTOF-MS was performed to explain the wound response of lettuce after cutting and to identify the metabolites responsible of browning. Two cultivars of Romaine lettuce with different browning susceptibilities were studied at short time intervals after cutting. From the total 5975 entities obtained from the raw data after alignment, filtration reduced the number of features to 2959, and the statistical analysis found that only 1132 entities were significantly different...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28485254/high-dietary-arachidonic-acid-levels-induce-changes-in-complex-lipids-and-immune-related-eicosanoids-and-increase-levels-of-oxidised-metabolites-in-zebrafish-danio-rerio
#3
Anne-Catrin Adam, Kai K Lie, Mari Moren, Kaja H Skjærven
This study explores the effect of high dietary arachidonic acid (ARA) levels (high ARA) compared with low dietary ARA levels (control) on the general metabolism using zebrafish as the model organism. The fatty acid composition of today's 'modern diet' tends towards higher n-6 PUFA levels in relation to n-3 PUFA. Low dietary n-3:n-6 PUFA ratio is a health concern, as n-6 PUFA give rise to eicosanoids and PG, which are traditionally considered pro-inflammatory, especially when derived from ARA. Juvenile zebrafish fed a high-ARA diet for 17 d had a lower whole-body n-3:n-6 PUFA ratio compared with zebrafish fed a low-ARA (control) diet (0·6 in the control group v...
May 9, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28460477/inhibition-of-lysophosphatidic-acid-receptor-ameliorates-sj%C3%A3-gren-s-syndrome-in-nod-mice
#4
Eunhye Park, Donghee Kim, Song Mi Lee, Hee-Sook Jun
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, is involved in the pathogenesis of chronic inflammatory and autoimmune diseases. In this study, we investigated the role of LPA/LPA receptor (LPAR) signaling in the pathogenesis of Sjögren's syndrome (SS). We found that autotaxin, an LPA producing enzyme, and LPAR1 and LPAR3 mRNA, and IL-17 mRNA were highly expressed in the exocrine glands of 20-week-old nonobese diabetic (NOD) mice, which show SS symptoms at this age, as compared with non-symptomatic 8-week-old NOD mice...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28458672/group-v-secreted-phospholipase-a2-induces-the-release-of-proangiogenic-and-antiangiogenic-factors-by-human-neutrophils
#5
Stefania Loffredo, Francesco Borriello, Raffaella Iannone, Anne L Ferrara, Maria R Galdiero, Vincenzo Gigantino, Pasquale Esposito, Gilda Varricchi, Gerard Lambeau, Marco A Cassatella, Francescopaolo Granata, Gianni Marone
Secreted phospholipases A2 (sPLA2s) are extracellular enzymes that catalyze the release of free fatty acids and lysophospholipids from membrane phospholipids and also bind to different receptors (e.g., PLA2R1 or integrins). To date, 12 mammalian sPLA2s have been identified, which play a critical role in pathophysiological processes including inflammation and cancer. sPLA2s activate immune cells such as human neutrophils (PMNs) by enzymatic activity- or receptor-mediated mechanisms. In addition, human PMNs synthesize and store human group V (hGV) and human group X (hGX) sPLA2s in their granules, but only the former is released upon cellular activation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28458280/immunological-regulation-by-bioactive-lipids
#6
Yoshitaka Taketomi, Makoto Murakami
 Mast cells originate from hematopoietic stem cells and undergo terminal maturation in the extravascular tissues, in which they are ultimately resident. Mast maturation, phenotype, and function are dictated by the local microenvironment, which has a significant influence on the ability of mast cells to recognize and respond to stimuli. Activation of mast cells can lead to the release of three distinct classes of mediators, including preformed mediators stored in secretory granules, newly transcribed cytokines and chemokines, and de novo-synthesized bioactive lipid mediators...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28450005/time-resolved-comparative-metabolomes-for-koji-fermentation-with-brown-white-and-giant-embryo-rice
#7
Da Eun Lee, Sunmin Lee, Digar Singh, Eun Seok Jang, Hye Won Shin, Byoung Seok Moon, Choong Hwan Lee
A time-resolved non-targeted metabolomic study towards evaluating the effects of three rice substrate types viz., white rice (WR), giant embryo rice (GER), and brown rice (BR), on Koji fermentation was performed. Notwithstanding the relatively higher proportions of metabolites in unfermented BR (BR 0>WR 0, GER 0), the relative levels of metabolic repertoire in BR Koji were marginally enhanced during 36h fermentation except those for phenolic acids, fatty acids, and vitamins. The WR Koji showed higher levels of lysophospholipids (LysoPC's) and protease-released amino acids (WR 36>GER 36>BR 36)...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28445851/development-and-validation-of-a-uhplc-esi-ms-ms-method-for-the-simultaneous-quantification-of-mammal-lysophosphatidylcholines-and-lysophosphatidylethanolamines-in-serum
#8
Susana Suárez-García, Lluís Arola, Aïda Pascual-Serrano, Anna Arola-Arnal, Gerard Aragonès, Cinta Bladé, Manuel Suárez
Recent investigations based on non-targeted metabolomics have proposed lysophospholipids (Lyso-PLs) as biomarkers of different diseases. In particular, lysophosphatidylcholines (Lyso-PCs) and lysophosphatidylethanolamines (Lyso-PEs) have been associated with serious lipid pathologies. Methods to determine the different molecular species in a biological sample and to quantify even less abundant species are required for the evaluation of the Lyso-PL pattern as a novel comprehensive biomarker of dyslipidemia. This study describes the development and validation of an ultra-high-performance liquid chromatography coupled to tandem mass spectrometry assay for the determination of a large number of Lyso-PCs and Lyso-PEs in biological samples...
April 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28444343/lysolecithin-as-feed-additive-enhances-collagen-expression-and-villus-length-in-the-jejunum-of-broiler-chickens
#9
D L Brautigan, R Li, E Kubicka, S D Turner, J S Garcia, M L Weintraut, E A Wong
Adding lysolecithin to feed has reportedly improved the performance of broiler chickens. Lysolecithin is generated by phospholipase catalyzed hydrolysis of lecithin. The enzymatic reaction converts various phospholipids into the corresponding lysophospholipids, with lysophosphatidylcholine (LPC) one of the primary products. Here we compared supplementation with a commercial lysolecithin (Lysoforte®) with comparable levels of highly purified LPC for effects on broilers. Despite no differences in weight gain during the starter period, we discovered a significant increase in average villus length with lysolecithin and an increase in villus width with purified LPC...
April 24, 2017: Poultry Science
https://www.readbyqxmd.com/read/28440547/development-of-lc-qtof-ms-method-for-human-lung-tissue-fingerprinting-a-preliminary-application-to-non-small-cell-lung-cancer
#10
Michal Ciborowski, Joanna Kisluk, Karolina Pietrowska, Paulina Samczuk, Ewa Parfieniuk, Tomasz Kowalczyk, Miroslaw Kozlowski, Adam Kretowski, Jacek Niklinski
The major histologic subtypes of non-small cell lung cancer (NSCLC) include adenocarcinoma (ADC), squamous cell lung carcinoma (SCC), and large-cell carcinoma (LCC). Clinical trials of targeted agents and newer chemotherapy agents yielded differences in outcomes according to histologic subgroups providing a rationale for histology-based treatment in NSCLC. Currently NSCLC subtyping is performed based on histopathological examinations and immunohistochemistry. However available methods leave about 10% of NSCLC cases as not otherwise specified...
April 25, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28418499/sphingosine-1-phosphate-s1p-related-response-of-human-conjunctival-fibroblasts-after-filtration-surgery-for-glaucoma
#11
Yuka Aoyama-Araki, Megumi Honjo, Takatoshi Uchida, Reiko Yamagishi, Kuniyuki Kano, Junken Aoki, Makoto Aihara
Purpose: To investigate levels of sphingosine-1-phosphate (S1P) in aqueous fluid samples taken before and after filtration surgery and S1P-induced human conjunctival fibroblast (HCF) responses. Methods: Levels of S1P and its related sphingophospholipids in aqueous fluid obtained immediately before and after filtration surgery were determined by liquid chromatography-tandem mass spectrometry. HCFs were used for all in vitro experiments. The expression of five S1P receptor subtypes in HCFs was examined by quantitative real-time PCR...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28415015/lipidomics-by-ultrahigh-performance-liquid-chromatography-high-resolution-mass-spectrometry-and-its-application-to-complex-biological-samples
#12
Alexander Triebl, Martin Trötzmüller, Jürgen Hartler, Tatjana Stojakovic, Harald C Köfeler
An improved approach for selective and sensitive identification and quantitation of lipid molecular species using reversed phase chromatography coupled to high resolution mass spectrometry was developed. The method is applicable to a wide variety of biological matrices using a simple liquid-liquid extraction procedure. Together, this approach combines multiple selectivity criteria: Reversed phase chromatography separates lipids according to their acyl chain length and degree of unsaturation and is capable of resolving positional isomers of lysophospholipids, as well as structural isomers of diacyl phospholipids and glycerolipids...
March 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28413196/the-molecular-cues-regulating-immune-cell-trafficking
#13
REVIEW
Akira Takeda, Naoko Sasaki, Masayuki Miyasaka
Lymphocyte recirculation between the blood and the lymphoid/non-lymphoid tissues is an essential homeostatic mechanism that regulates humoral and cellular immune responses in vivo. This system promotes the encounter of naïve T and B cells with their specific cognate antigen presented by dendritic cells, and with the regulatory cells with which they need to interact to initiate, maintain, and terminate immune responses. The constitutive lymphocyte trafficking is mediated by particular types of blood vessels, including the high endothelial venules (HEVs) in lymph nodes and Peyer's patches, and the flat-walled venules in non-lymphoid tissues including the skin...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/28408542/acyl-coa-lysophosphatidylethanolamine-acyltransferase-activity-affects-growth
#14
Katarzyna Jasieniecka-Gazarkiewicz, Ida Lager, Anders Carlsson, Katharina Gutbrod, Helga Peisker, Peter Dörmann, Sten Stymne, Antoni Banas
Arabidopsis contains two enzymes (encoded by the At1g80950 and At2g456702 genes) preferentially acylating lyso-phosphatidylethanolamine (LPE) with acyl-CoA, designated lyso-phosphatidylethanolamine acyltransferase 1 (LPEAT1) and lyso-phosphatidylethanolamine acyltransferase 2 (LPEAT2). T-DNA insertion mutants of lpeat2 and double mutants of lpeat1 lpeat2 showed impaired growth, smaller leaves, shorter roots, less seed setting and reduced lipid content per FW in roots and seeds and large increases in LPE and lyso-phosphatidylcholine (LPC) contents in leaves...
April 13, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28376314/endogenous-lysophosphatidic-acid-participates-in-vascularisation-and-decidualisation-at-the-maternal-fetal-interface-in-the-rat
#15
Micaela S Sordelli, Jimena S Beltrame, Elsa Zotta, Natalia Gomez, Ganna Dmytrenko, María Elena Sales, Sandra M Blois, Carlos Davio, Silvina Perez Martinez, Ana M Franchi, María L Ribeiro
Lysophosphatidic acid (LPA) affects several female reproductive functions through G-protein-coupled receptors. LPA contributes to embryo implantation via the lysophospholipid LPA3 receptor. In the present study we investigated the participation of endogenous LPA signalling through the LPA3 receptor in vascularisation and decidualisation, two crucial events at the maternal-fetal interface. Pregnant rats were treated with diacylglycerol pyrophosphate (DGPP), a highly selective antagonist of LPA3 receptors, on Day 5 of gestation...
April 5, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28367448/differential-s1p-receptor-profiles-on-m1-and-m2-polarized-macrophages-affect-macrophage-cytokine-production-and-migration
#16
Jan Müller, Wolfram von Bernstorff, Claus-Dieter Heidecke, Tobias Schulze
Introduction. Macrophages are key players in complex biological processes. In response to environmental signals, macrophages undergo polarization towards a proinflammatory (M1) or anti-inflammatory (M2) phenotype. Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid that acts via 5 G-protein coupled receptors (S1P1-5) in order to influence a broad spectrum of biological processes. This study assesses S1P receptor expression on macrophages before and after M1 and M2 polarization and performs a comparative analysis of S1P signalling in the two activational states of macrophages...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28358327/coenzyme-a-independent-transacylation-system-possible-involvement-of-phospholipase-a2-in-transacylation
#17
REVIEW
Atsushi Yamashita, Yasuhiro Hayashi, Naoki Matsumoto, Yoko Nemoto-Sasaki, Takanori Koizumi, Yusuke Inagaki, Saori Oka, Takashi Tanikawa, Takayuki Sugiura
The coenzyme A (CoA)-independent transacylation system catalyzes fatty acid transfer from phospholipids to lysophospholipids in the absence of cofactors such as CoA. It prefers to use C20 and C22 polyunsaturated fatty acids such as arachidonic acid, which are esterified in the glycerophospholipid at the sn-2 position. This system can also acylate alkyl ether-linked lysophospholipids, is involved in the enrichment of arachidonic acid in alkyl ether-linked glycerophospholipids, and is critical for the metabolism of eicosanoids and platelet-activating factor...
March 30, 2017: Biology
https://www.readbyqxmd.com/read/28341849/quantitative-profiling-of-glycerophospholipids-during-mouse-and-human-macrophage-differentiation-using-targeted-mass-spectrometry
#18
Cuiping Zhang, Yi Wang, Fang Wang, Zhenxin Wang, Yu Lu, Ying Xu, Ke Wang, Huali Shen, Pengyuan Yang, Shan Li, Xue Qin, Hongxiu Yu
Macrophage lipid metabolism plays a pivotal role in innate and adaptive immune responses. Previous studies have shown that this process plays a role in infections and contributes to the pathogenesis of diabetes, atherosclerosis, and other immunometabolic diseases. M1 macrophages, or classically activated macrophages, are key players in the defense against bacterial infections. M2 macrophages, or alternatively activated macrophages, are involved in anti-inflammatory responses. Using the multiple reaction monitoring method, we identified changes in lipid composition during the differentiation of human and murine macrophages...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325059/lysophospholipids-and-their-receptors-serve-as-conditional-damps-and-damp-receptors-in-tissue-oxidative-and-inflammatory-injury
#19
Ying Shao, Gayani Nanayakkara, Jiali Cheng, Ramon Cueto, William Y Yang, Joon-Young Park, Hong Wang, Xiaofeng Yang
SIGNIFICANCE: We proposed lysophospholipids (LPLs) and LPL-G-protein-coupled receptors (GPCRs) as conditional danger-associated molecular patterns (DAMPs) and conditional DAMP receptors as a paradigm shift to the widely accepted classical DAMP and DAMP receptor model. Recent Advances: The aberrant levels of LPLs and GPCRs activate pro-inflammatory signal transduction pathways, trigger innate immune response, and lead to tissue oxidative and inflammatory injury. CRITICAL ISSUES: Classical DAMP model specifies only the endogenous metabolites that are released from damaged/dying cells as DAMPs, but fails to identify elevated endogenous metabolites secreted from viable/live cells during pathologies as DAMPs...
April 26, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28314215/a-metabolomic-approach-shows-sphingosine-1-phosphate-and-lysophospholipids-as-mediators-of-the-therapeutic-effect-of-liver-growth-factor-in-emphysema
#20
A Navarrete, F J Rupérez, T O Mendes, S Pérez-Rial, A Girón-Martínez, R Terrón-Expósito, J J Díaz-Gil, G Peces-Barba, C Barbas, A García
Tobacco smoke exposure is the principal cause of lung tissue destruction, which in turn results in emphysema that leads into shortness of breath. Liver growth factor (LGF, a cell and tissue regenerating factor with therapeutic activity in several organs) has antifibrotic and antioxidant properties that could be useful to promote lung tissue regenerating capacity in damaged lungs. The current study has examined differences in metabolite profiles (fingerprints) of plasma from mice (strain C57BL/6J, susceptible to develop emphysema) exposed to tobacco smoke during six months...
May 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
keyword
keyword
11048
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"