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Aspirin AND COX

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https://www.readbyqxmd.com/read/28782132/aspirin-and-incident-depressive-symptoms-a-longitudinal-cohort-study-over-8%C3%A2-years
#1
Nicola Veronese, Ai Koyanagi, Brendon Stubbs, Marco Solmi, Michele Fornaro, Brisa F Fernandes, Christoph Muller, Trevor Thompson, André F Carvalho, Stefania Maggi
OBJECTIVE: Aspirin exhibits anti-atherosclerotic and anti-inflammatory properties-two potential risk factors for depression. The relationship between aspirin use and depression, however, remains unclear. We investigated whether the aspirin use is associated with a decreased incidence of depressive symptoms in a large North American cohort. METHODS: Data from the Osteoarthritis Initiative dataset, a multicenter, longitudinal study on community-dwelling adults was analyzed...
August 6, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28781013/early-aspirin-use-and-the-development-of-cardiac-allograft-vasculopathy
#2
Miae Kim, Brian A Bergmark, Thomas A Zelniker, Mandeep R Mehra, Garrick C Stewart, Deborah S Page, Erica L Woodcome, Jennifer A Smallwood, Steven Gabardi, Michael M Givertz
BACKGROUND: Cardiac allograft vasculopathy (CAV) remains a leading cause of morbidity and mortality after orthotopic heart transplantation (OHT). Little is known about the influence of aspirin on clinical expression of CAV. METHODS: We followed 120 patients with OHT at a single center for a median of 7 years and categorized them by the presence or absence of early aspirin therapy post-transplant (aspirin treatment ≥6 months in the first year). The association between aspirin use and time to the primary end-point of angiographic moderate or severe CAV (International Society for Heart and Lung Transplantation grade ≥2) was investigated...
July 3, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28780034/impact-of-aspirin-and-clopidogrel-hyporesponsiveness-in-patients-treated%C3%A2-with-drug-eluting-stents-2-year-results-of-a-prospective-multicenter-registry-study
#3
Thomas D Stuckey, Ajay J Kirtane, Bruce R Brodie, Bernhard Witzenbichler, Claire Litherland, Giora Weisz, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Paul A Gurbel, Roxana Mehran, Philippe Généreux, Ori Ben-Yehuda, Charles A Simonton, Gregg W Stone
OBJECTIVES: In this analysis of 2-year outcomes in the ADAPT-DES (Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents) study, the authors sought to examine the independent associations between platelet reactivity to both aspirin and clopidogrel and subsequent outcomes. BACKGROUND: The relationship between platelet reactivity and long-term adverse events following implantation of drug-eluting stents (DES) has been incompletely characterized. METHODS: The ADAPT-DES study was a multicenter registry of patients undergoing routine platelet function testing following percutaneous coronary intervention with DES...
July 27, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28774396/aspirin-does-not-increase-heart-failure%C3%A2-events-in-heart-failure-patients-from-the-warcef%C3%A2-trial
#4
John R Teerlink, Min Qian, Natalie A Bello, Ronald S Freudenberger, Bruce Levin, Marco R Di Tullio, Susan Graham, Douglas L Mann, Ralph L Sacco, J P Mohr, Gregory Y H Lip, Arthur J Labovitz, Seitetz C Lee, Piotr Ponikowski, Dirk J Lok, Stefan D Anker, John L P Thompson, Shunichi Homma
OBJECTIVES: The aim of this study was to determine whether aspirin increases heart failure (HF) hospitalization or death in patients with HF with reduced ejection fraction receiving an angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB). BACKGROUND: Because of its cyclooxygenase inhibiting properties, aspirin has been postulated to increase HF events in patients treated with ACE inhibitors or ARBs. However, no large randomized trial has addressed the clinical relevance of this issue...
August 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/28768848/predicting-major-bleeding-in-patients-with-noncardioembolic-stroke-on-antiplatelets-s2top-bleed
#5
Nina A Hilkens, Ale Algra, Hans-Christoph Diener, Johannes B Reitsma, Philip M Bath, Laszlo Csiba, Werner Hacke, L Jaap Kappelle, Peter J Koudstaal, Didier Leys, Jean-Louis Mas, Ralph L Sacco, Pierre Amarenco, Leila Sissani, Jacoba P Greving
OBJECTIVE: To develop and externally validate a prediction model for major bleeding in patients with a TIA or ischemic stroke on antiplatelet agents. METHODS: We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, and PRoFESS) investigating antiplatelet therapy after TIA or ischemic stroke. Cox regression analyses stratified by trial were performed to study the association between predictors and major bleeding...
August 2, 2017: Neurology
https://www.readbyqxmd.com/read/28768046/carbon-monoxide-released-from-its-pharmacological-donor-tricarbonyldichlororuthenium-ii-dimer-corm-2-accelerates-the-healing-of-pre-existing-gastric-ulcers
#6
Magierowski Marcin, Magierowska Katarzyna, Hubalewska-Mazgaj Magdalena, Sliwowski Zbigniew, Ginter Grzegorz, Pajdo Robert, Chmura Anna, Kwiecien Slawomir, Brzozowski Tomasz
BACKGROUND AND PURPOSE: Carbon monoxide (CO), gaseous mediator produced by heme oxygenases (HO), has been shown to prevent stress-, ethanol-, aspirin- or alendronate-induced gastric damage, however, its role in the gastric ulcer healing has not been fully explained. We investigated whether CO released from tricarbonyldichlororuthenium (II) dimer (CORM-2) can affect gastric ulcer healing and determined mechanisms involved in healing action of this compound. EXPERIMENTAL APPROACH: Gastric ulcers were induced in Wistar rats by serosal application of acetic acid...
August 2, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28762014/beyond-cox-1-the-effects-of-aspirin-on-platelet-biology-and-potential-mechanisms-of-chemoprevention
#7
Argentina Ornelas, Niki Zacharias-Millward, David G Menter, Jennifer S Davis, Lenard Lichtenberger, David Hawke, Ernest Hawk, Eduardo Vilar, Pratip Bhattacharya, Steven Millward
After more than a century, aspirin remains one of the most commonly used drugs in western medicine. Although mainly used for its anti-thrombotic, anti-pyretic, and analgesic properties, a multitude of clinical studies have provided convincing evidence that regular, low-dose aspirin use dramatically lowers the risk of cancer. These observations coincide with recent studies showing a functional relationship between platelets and tumors, suggesting that aspirin's chemopreventive properties may result, in part, from direct modulation of platelet biology and biochemistry...
July 31, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28756905/aspirin-versus-clopidogrel-for-type-2-diabetic-patients-with-first-ever-noncardioembolic-acute-ischemic-stroke-ten-year-survival-data-from-the-athens-stroke-outcome-project
#8
Haralampos Milionis, George Ntaios, Vasileios Papavasileiou, Konstantinos Spengos, Efstathios Manios, Moses Elisaf, Konstantinos Vemmos
BACKGROUND AND OBJECTIVE: Diabetes mellitus is associated with an increased risk of stroke and poor outcome following a stroke event. We assessed the impact of discharge treatment with aspirin versus clopidogrel on the 10-year survival of patients with type 2 diabetes after a first-ever noncardioembolic acute ischemic stroke (AIS). METHODS: This was a post hoc analysis of the Athens Stroke Outcome Project. Study outcomes included death, stroke recurrence, and a composite cardiovascular disease (CVD) end point (recurrent stroke, myocardial infarction, unstable angina, coronary revascularization, aortic aneurysm rupture, or sudden death)...
July 27, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28725937/aspirin-use-and-head-and-neck-cancer-survival-an-observational-study-of-11-623-person-years-follow-up
#9
Shin-Ae Kim, Jong-Lyel Roh, Sung-Bae Kim, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Acetylsalicylic acid (aspirin) and non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with reduced risks for certain human cancers. However, the effects of aspirin and NSAIDs on head and neck squamous cell carcinoma (HNSCC) remain controversial, and the prognostic effects of these drugs in patients with HNSCC are largely unknown. This study examined the clinical impact of aspirin and NSAIDs on disease recurrence and survival in patients with HNSCC. METHODS: This study analysed a cohort of 1392 consecutive patients who received definitive treatment for previously untreated HNSCC at our tertiary referral center...
July 19, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28706001/aspirin-as-a-cox-inhibitor-and-anti-inflammatory-drug-in-human-skeletal-muscle
#10
Steve M Ratchford, Kaleen M Lavin, Ryan K Perkins, Bozena Jemiolo, Scott W Trappe, Todd A Trappe
Although aspirin is one of the most common anti-inflammatory drugs in the world, the effect of aspirin on human skeletal muscle inflammation is almost completely unknown. This study examined the potential effects and related time course of an orally consumed aspirin dose on the inflammatory PGE2/COX pathway in human skeletal muscle. Skeletal muscle biopsies were taken from the vastus lateralis of 10 healthy adults (5M/5F, 25±2y) before and 2, 4, and 24h after consuming a standard dose of aspirin (975mg) and partitioned for analysis of 1) in vivo PGE2 levels in resting skeletal muscle and 2) ex vivo skeletal muscle PGE2 production when stimulated with the COX substrate arachidonic acid (5μM)...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28700965/inhibitory-effects-of-asp6537-a-selective-cyclooxygenase-1-inhibitor-on-thrombosis-and-neointima-formation-in-rats
#11
Chinatsu Sakata, Tomihisa Kawasaki, Yoshiyuki Iwatsuki, Yumiko Moritani, Yoshiaki Morita, Hideaki Hara
INTRODUCTION: Percutaneous coronary interventions (PCIs), such as balloon angioplasty and stent placement, are effective in the treatment of coronary artery disease. PCI has drawbacks, however, including acute thrombosis after the procedure and restenosis of the vascular lumen due to abnormal neointimal hyperplasia. ASP6537 is a selective COX-1 inhibitor that has been investigated as a possible candidate for clinical development as an antiplatelet agent. In the present study, we evaluated the in vivo antithrombotic effect of ASP6537 and its effect on neointima formation after balloon angioplasty...
July 2, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28695614/use-of-anti-inflammatory-analgesics-in-sickle-cell-disease
#12
J Han, S L Saraf, J P Lash, V R Gordeuk
WHAT IS KNOWN AND OBJECTIVE: Non-steroidal anti-inflammatory drugs (NSAIDs) have been commonly used to treat pain in sickle-cell disease (SCD), but NSAID use is associated with renal, gastrointestinal and cardiovascular toxicities. Our objective was to evaluate the use of aspirin and non-aspirin NSAIDs in SCD. COMMENT: Despite analgesic and anti-inflammatory benefits in SCD, non-aspirin NSAIDs are associated with renal, cardiovascular and gastrointestinal toxicities in this patient population...
July 10, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28692590/vestibular-schwannoma-growth-with-aspirin-and-other-nonsteroidal-anti-inflammatory-drugs
#13
Jacob B Hunter, Brendan P O'Connell, George B Wanna, Marc L Bennett, Alejandro Rivas, Reid C Thompson, David S Haynes
OBJECTIVE: To investigate whether the use of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) impact the growth of vestibular schwannoma (VS). STUDY DESIGN: Retrospective case series. SETTING: Single academic, tertiary care center. PATIENTS: Patients with VS who underwent at least two magnetic resonance imaging (MRI) studies before intervention. INTERVENTION(S): Serial MRI studies...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28683466/commonly-used-medications-and-endometrial-cancer-survival-a-population-based-cohort-study
#14
Omolara B Sanni, Úna C Mc Menamin, Chris R Cardwell, Linda Sharp, Liam J Murray, Helen G Coleman
BACKGROUND: Increasing incidence and new indications for existing drugs make it important to identify new adjuvant therapies for endometrial cancer (EC). METHODS: This is a prospective cohort study of 3058 newly diagnosed EC cases from 1998 to 2010, identified through record linkages between the UK Clinical Practice Research Datalink, the National Cancer Research Datalink and death registrations from the Office of National Statistics. Using Cox regression models, unadjusted and adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for EC-specific survival...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28682183/interaction-between-nonsteroidal-anti-inflammatory-drugs-and-low-fat-dietary-intervention-on-colorectal-cancer-incidence-the-women-s-health-initiative-whi-dietary-modification-trial
#15
Ikuko Kato, Dorothy Lane, Catherine R Womack, Cathryn H Bock, Lifang Hou, Jennifer H Lin, Chunyuan Wu, Jennifer Beebe Dimmer, Michael S Simon
BACKGROUND: The Women's Health Initiative (WHI) Dietary Modification (DM) trial did not show that reductions in dietary fat accompanied by increases in vegetable and fruit consumption decrease the incidence of colorectal cancer. Secondary analyses suggested that aspirin use may modify the intervention effects of DM on colorectal cancer development, although a recent reanalysis including the postintervention period confirmed no main effect of the intervention on reducing colorectal cancer incidence Methods: We analyzed data from 48,834 postmenopausal women who were randomized into the low-fat DM (N = 19,540) or comparison (N = 29,294) group for an average 8...
July 6, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28676124/evaluation-of-rational-nonsteroidal-anti-inflammatory-drugs-and-gastro-protective-agents-use-association-rule-data-mining-using-outpatient-prescription-patterns
#16
Oraluck Pattanaprateep, Mark McEvoy, John Attia, Ammarin Thakkinstian
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) and gastro-protective agents should be co-prescribed following a standard clinical practice guideline; however, adherence to this guideline in routine practice is unknown. This study applied an association rule model (ARM) to estimate rational NSAIDs and gastro-protective agents use in an outpatient prescriptions dataset. METHODS: A database of hospital outpatients from October 1st, 2013 to September 30th, 2015 was searched for any of following drugs: oral antacids (A02A), peptic ulcer and gastro-oesophageal reflux disease drugs (GORD, A02B), and anti-inflammatory and anti-rheumatic products, non-steroids or NSAIDs (M01A)...
July 4, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28638310/analysis-of-gene-expression-in-human-dermal-fibroblasts-treated-with-senescence-modulating-cox-inhibitors
#17
Jeong A Han, Jong-Il Kim
We have previously reported that NS-398, a cyclooxygenase-2 (COX-2)-selective inhibitor, inhibited replicative cellular senescence in human dermal fibroblasts and skin aging in hairless mice. In contrast, celecoxib, another COX-2-selective inhibitor, and aspirin, a non-selective COX inhibitor, accelerated the senescence and aging. To figure out causal factors for the senescence-modulating effect of the inhibitors, we here performed cDNA microarray experiment and subsequent Gene Set Enrichment Analysis. The data showed that several senescence-related gene sets were regulated by the inhibitor treatment...
June 2017: Genomics & Informatics
https://www.readbyqxmd.com/read/28626088/secondary-prevention-of-cardiovascular-disease-in-patients-with-type-2-diabetes-international-insights-from-the-tecos-trial
#18
Neha J Pagidipati, Ann Marie Navar, Karen S Pieper, Jennifer B Green, M Angelyn Bethel, Paul W Armstrong, Robert G Josse, Darren K McGuire, Yuliya Lokhnygina, Jan H Cornel, Sigrun Halvorsen, Timo E Strandberg, Tuncay Delibasi, Rury R Holman, Eric D Peterson
Background -Intensive risk factor modification significantly improves outcomes for patients with diabetes and cardiovascular disease (CVD). However, the degree to which secondary prevention treatment goals are achieved in international clinical practice is unknown. Methods -Attainment of 5 secondary prevention parameters-aspirin use, lipid control (low-density lipoprotein cholesterol <70 mg/dL or statin therapy), blood pressure control (<140 mmHg systolic, <90 mmHg diastolic), angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use, and non-smoking status-was evaluated among 13,616 patients from 38 countries with diabetes and known CVD at entry into TECOS...
June 16, 2017: Circulation
https://www.readbyqxmd.com/read/28620089/development-and-validation-of-risk-prediction-equations-to-estimate-survival-in-patients-with-colorectal-cancer-cohort-study
#19
Julia Hippisley-Cox, Carol Coupland
Objective To develop and externally validate risk prediction equations to estimate absolute and conditional survival in patients with colorectal cancer. Design Cohort study.Setting General practices in England providing data for the QResearch database linked to the national cancer registry.Participants 44 145 patients aged 15-99 with colorectal cancer from 947 practices to derive the equations. The equations were validated in 15 214 patients with colorectal cancer from 305 different QResearch practices and 437 821 patients with colorectal cancer from the national cancer registry...
June 15, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28617992/antiplatelet-therapy-and-the-risk-of-hepatocellular-carcinoma-in-chronic-hepatitis-b-patients-on-antiviral-treatment
#20
Minjong Lee, Goh Eun Chung, Jeong-Hoon Lee, Sohee Oh, Joon Yeul Nam, Young Chang, Hyeki Cho, Hongkeun Ahn, Young Youn Cho, Jeong-Ju Yoo, Yuri Cho, Dong Hyeon Lee, Eun Ju Cho, Su Jong Yu, Dong Ho Lee, Jeong Min Lee, Yoon Jun Kim, Jung-Hwan Yoon
Antiplatelet therapy has shown protective effects against hepatocellular carcinoma (HCC) in preclinical studies. However, it is unclear whether antiplatelet therapy lowers the risk of HCC in patients with chronic hepatitis B (CHB). A retrospective analysis was conducted of data from 1,674 CHB patients, enrolled between January 2002 and May 2015, whose serum hepatitis B virus (HBV) DNA levels were suppressed by antivirals to <2,000 IU/mL. The primary and secondary outcomes were development of HCC and bleeding events, respectively...
June 15, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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