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https://www.readbyqxmd.com/read/30218743/the-effects-of-cardiovascular-risk-factor-combined-anti-platelet-therapy-and-the-risk-of-cerebrovascular-events-in-patients-with-t2dm-in-an-urban-community-over-96-months-follow-up-the-beijing-communities-diabetes-study-19
#1
Xue-Lian Zhang, Han-Jing Fu, Guang-Ran Yang, Gang Wan, Dongmei Li, Liang-Xiang Zhu, Rong-Rong Xie, Yu-Jie Lv, Jian-Dong Zhang, Yu-Ling Li, Qin-Fang Dai, Yu Ji, Da-Yong Gao, Xue-Li Cui, De-Yuan Liu, Shen-Yuan Yuan, Ming-Xia Yuan
OBJECTIVE: We investigated the prognostic significance of metabolic risk scores and aspirin with respect to cerebrovascular events. METHODS: A total of 25 communities of diabetic patients were enrolled in Beijing Community Diabetes Study (BCDS) from 2008. 3413 patients with T2DM in BCDS have complete screening data, including blood glucose, blood pressure, lipid profiles and anti-platelet therapy, which were assigned metabolic score (MS) and add up to the total metabolic score (TMS)...
September 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/30214631/aspirin-cooperates-with-p300-to-activate-the-acetylation-of-h3k9-and-promote-fasl-mediated-apoptosis-of-cancer-stem-like-cells-in-colorectal-cancer
#2
Zhigang Chen, Wenlu Li, Fuming Qiu, Qi Huang, Zhou Jiang, Jun Ye, Pu Cheng, Cho Low, Yikun Guo, Xinchi Yi, Wenteng Chen, Yongpin Yu, YueHua Han, Jun Wu, Shenghang Jin, Dong Kong, Jian Huang
Cancer stem-like cells (CSCs) have been proposed as a key driving force of tumor growth and relapse in colorectal cancer (CRC), and therefore, they are promising targets for cancer therapy. Epidemiological evidence has suggested that the daily use of aspirin reduces overall mortality of CRC and the risk of distant metastasis. We investigated the effect and mechanism of aspirin on CSCs in CRC. Methods: The ratio of CSCs was analyzed after aspirin treatment both in a cell model and patient samples. Chemically modified aspirin and immunoprecipitation were adopted to detect the target proteins of aspirin...
2018: Theranostics
https://www.readbyqxmd.com/read/30197973/inequality-in-care-and-differences-in-outcome-following-stroke-in-people-with-esrd
#3
Mark D Findlay, Jesse Dawson, Rachael MacIsaac, Alan G Jardine, Mary Joan MacLeod, Wendy Metcalfe, Jamie P Traynor, Patrick B Mark
Introduction: Stroke rate and mortality are greater in individuals with end-stage renal disease (ESRD) than in those without ESRD. We examined discrepancies in stroke care in ESRD patients and their influence on mortality. Methods: This is a national record linkage cohort study of hospitalized stroke individuals from 2005 to 2013. Presentation, measures of care quality (admission to stroke unit, swallow assessment, antithrombotics, or thrombolysis use), and outcomes were compared in those with and without ESRD after propensity score matching (PSM)...
September 2018: KI Reports
https://www.readbyqxmd.com/read/30196181/impact-of-high-on-aspirin-platelet-reactivity-on-outcomes-following-successful-percutaneous-coronary-intervention-with-drug-eluting-stents
#4
Christine J Chung, Ajay J Kirtane, Yiran Zhang, Bernhard Witzenbichler, Giora Weisz, Thomas D Stuckey, Bruce R Brodie, Michael J Rinaldi, Franz-Josef Neumann, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Roxana Mehran, Gregg W Stone
BACKGROUND: Whether high on-aspirin platelet reactivity (HAPR) confers an increased risk of adverse outcomes after percutaneous coronary intervention (PCI) remains unclear. We sought to examine the specific relationship between HAPR and clinical outcomes in ADAPT-DES. METHODS: A total of 8,526 "all-comer" patients in the ADAPT-DES registry who underwent placement of drug-eluting stents (DES) and were treated with aspirin and clopidogrel were assessed to measure platelet reactivity...
August 15, 2018: American Heart Journal
https://www.readbyqxmd.com/read/30188953/chronic-obstructive-pulmonary-disease-with-short-acting-inhaled-pharmacotherapy-increases-the-risk-of-prostate-cancer-a-two-stage-database-approach
#5
Hui-Wen Lin, Li-Fong Lin, Hung-Chou Chen, Tsan-Hon Liou, Shih-Wei Huang
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are at a higher risk of many types of cancer. However, specific investigation of the risk of prostate cancer and the influence of COPD pharmacotherapy in patients with COPD is lacking. This study investigated the risk and influence of COPD pharmacotherapy on risk of prostate cancer in patients with COPD. METHODS: This retrospective cohort study used data from Taiwan's Longitudinal Health Insurance Database 2005 (LHID2005)...
2018: PloS One
https://www.readbyqxmd.com/read/30179923/high-risk-of-venous-thromboembolism-after-surgery-for-long-bone-metastases-a-retrospective-study-of-682-patients
#6
Olivier Q Groot, Paul T Ogink, Stein J Janssen, Nuno Rui Paulino Pereira, Santiago Lozano-Calderon, Kevin Raskin, Francis Hornicek, Joseph H Schwab
BACKGROUND: Previous studies have shown that venous thromboembolism (VTE) is a complication associated with neoplastic disease and major orthopaedic surgery. However, many potential risk factors remain undefined. QUESTIONS/PURPOSES: (1) What proportion of patients develop symptomatic VTE after surgery for long bone metastases? (2) What factors are associated with the development of symptomatic VTE among patients receiving surgery for long bone metastases? (3) Is there an association between the development of symptomatic VTE and 1-year survival among patients undergoing surgery for long bone metastases? (4) Does chemoprophylaxis increase the risk of wound complications among patients undergoing surgery for long bone metastases? METHODS: A retrospective study identified 682 patients undergoing surgical treatment of long bone metastases between 2002 and 2013 at the Massachusetts General Hospital and Brigham and Women's Hospital...
August 31, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/30156911/effects-of-high-and-low-dose-aspirin-on-adaptive-immunity-and-hypertension-in-the-stroke-prone-spontaneously-hypertensive-rat
#7
Shanzana I Khan, Waled A Shihata, Karen L Andrews, Man K S Lee, Xiao-Lei Moore, Ann-Maree Jefferis, Antony Vinh, Tracey Gaspari, Dragana Dragoljevic, Garry L Jennings, Andrew J Murphy, Jaye P F Chin-Dusting
Despite its well-known antithrombotic properties, the effect of aspirin on blood pressure (BP) and hypertension pathology is unclear. The hugely varying doses used clinically have contributed to this confusion, with high-dose aspirin still commonly used due to concerns about the efficacy of low-dose aspirin. Because prostaglandins have been shown to both promote and inhibit T-cell activation, we also explored the immunomodulatory properties of aspirin in hypertension. Although the common preclinical high dose of 100 mg/kg per day improved vascular dysfunction and cardiac hypertrophy, this effect was accompanied by indices of elevated adaptive immunity, renal T-cell infiltration, renal fibrosis, and BP elevation in stroke-prone spontaneously hypertensive rats and in angiotensin II-induced hypertensive mice...
August 29, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30149897/unplanned-hospitalizations-in-a-racially-and-ethnically-diverse-population-of-women-receiving-chemotherapy-for-epithelial-ovarian-cancer
#8
Shayan Dioun, Jennifer R Jorgensen, Eirwen M Miller, Joan Tymon-Rosario, Xianhong Xie, Xiaonan Xue, Dennis Yi-Shin Kuo, Nicole S Nevadunsky
OBJECTIVES: Unplanned hospital admission following chemotherapy is a measure of quality cancer care. Large retrospective datasets have shown admission rates of 10-35% for women with ovarian cancer receiving chemotherapy. We sought to evaluate the prevalence and associated risk factors for hospital admission following chemotherapy in our racially diverse urban population. METHODS: After IRB approval, clinicopathologic and treatment data were abstracted from all patients with newly diagnosed epithelial ovarian cancer who received chemotherapy at our institution from 2005 to 2016...
August 24, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30149368/pharmacological-and-dietary-factors-in-prevention-of-colorectal-cancer
#9
M Waluga, M Zorniak, J Fichna, M Kukla, M Hartleb
Colorectal cancer (CRC) is the third most prevalent neoplasm worldwide and fourth most frequent reason of cancer-related death throughout the world. About 70% of malignant tumors are related to lifestyle and environmental factors, and better knowledge of their significance might reduce the prevalence of CRC. The cyclooxygenase-2 (COX-2) inhibitory and other direct and indirect pathways of aspirin are translated to inhibition proliferation and enhanced apoptosis of cancer cells. Many studies showed the benefits of aspirin in reducing the risk of CRC development, cancer-related mortality and adenoma prevalence rate in general population, but not in high risk populations...
June 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/30138389/risk-of-intracranial-hemorrhage-rich-in-users-of-oral-antithrombotic-drugs-nationwide-pharmacoepidemiological-study
#10
Sasha Gulati, Ole Solheim, Sven M Carlsen, Lise R Øie, Heidi Jensberg, Agnete M Gulati, Mattis A Madsbu, Charalampis Giannadakis, Asgeir S Jakola, Øyvind Salvesen
BACKGROUND: The risks of intracranial haemorrhage (ICH) associated with antithrombotic drugs outside clinical trials are gaining increased attention. The aim of this nationwide study was to investigate the risk of ICH requiring hospital admission in users of antithrombotic drugs. METHODS AND FINDINGS: Data from the Norwegian Patient Registry and Norwegian Prescription Database were linked on an individual level. The primary outcome was incidence rates of ICH associated with use of antithrombotic drugs...
2018: PloS One
https://www.readbyqxmd.com/read/30120531/antiplatelet-therapy-is-associated-with-stent-patency-after-iliocaval-venous-stenting
#11
Masayuki Endo, Younes Jahangiri, Masahiro Horikawa, John A Kaufman, Ryan C Schenning, Kenneth J Kolbeck, Robert E Barton, Yasufumi Ohuchi, Keng Wei Liang, Khashayar Farsad
PURPOSE: To examine the effectiveness of antithrombotic medications to prevent venous stent malfunction for iliocaval occlusive disease. MATERIALS AND METHODS: A retrospective analysis was performed on 62 patients who underwent technically successful endovascular iliocaval stent placement between May 2008 and April 2017. Clinical records were reviewed for demographic information, procedure details, post-stenting antithrombotic prophylaxis and stent patency on follow-up...
August 17, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/30106307/rational-druggability-investigation-toward-selection-of-lead-molecules-impact-of-the-commonly-used-spices-on-inflammatory-diseases
#12
Tara Zakerali, Sajad Shahbazi
Herbal remedies and phytochemicals have been used in traditional medicine. Most of the herbs used in human diet have some major effective elements that can affect various pathways in the human body and play a therapeutic role in healing disorders or diseases. Among the inflammatory diseases, worldwide common disorders possess well-known pathways that can be controlled by diet and behavior. There are some well-established targets that are used for anti-inflammatory drugs like cyclooxygenase type 1 and 2 (COX-1 and COX-2), lipoxygenase, prostaglandin D2 receptor, DP1, CRTH2, and so on...
August 14, 2018: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/30096040/residual-cyclooxygenase-activity-of-aspirin-acetylated-cox-2-forms-15-r-prostaglandins-that-inhibit-platelet-aggregation
#13
Juan A Giménez-Bastida, William E Boeglin, Olivier Boutaud, Michael G Malkowski, Claus Schneider
Aspirin (acetylsalicylic acid) inhibits prostaglandin (PG) synthesis by transfer of its acetyl group to a serine residue in the cyclooxygenase (COX) active site. Acetylation of Ser530 inhibits catalysis by preventing access of arachidonic acid substrate in the COX-1 isoenzyme. Acetylated COX-2, in contrast, gains a new catalytic activity and forms 15 R hydroxy-eicosatetraenoic acid (15 R-HETE) as alternate product. Here we show that acetylated COX-2 also retains COX activity, forming predominantly 15 R-configuration PGs (70 or 62% 15 R, respectively, determined using radiolabeled substrate or LC-MS analysis)...
August 10, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30081159/metformin-is-associated-with-improved-survival-and-decreased-cardiac-events-with-no-impact-on-patency-and-limb-salvage-after-revascularization-for-peripheral-arterial-disease
#14
Sikandar Z Khan, Mariel Rivero, Nader D Nader, Gregory S Cherr, Linda M Harris, Maciej L Dryjski, Hasan H Dosluoglu
BACKGROUND: The incidence of cardiovascular and limb-specific adverse outcomes is higher in peripheral arterial disease (PAD) patients with diabetes. Metformin is associated with improved cardiovascular morbidity and mortality. However, the effect of metformin on limb-specific outcomes is unclear. The objective of this study was to assess the effect of metformin on outcomes after intervention for PAD. METHODS: Patients who underwent revascularization for chronic limb ischemia (Rutherford 3-6) between June 2001 and December 2014 were retrospectively identified...
August 4, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30072125/effect-of-antiplatelet-therapy-aspirin-dipyridamole-versus-clopidogrel-on-mortality-outcome-in-ischemic-stroke
#15
Raphae S Barlas, Yoon K Loke, Mamas A Mamas, Joao H Bettencourt-Silva, Isobel Ford, Allan B Clark, Kristian M Bowles, Anthony K Metcalf, John F Potter, Phyo K Myint
The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectively collected data from the Norfolk and Norwich University Hospital Stroke Register. The sample population consisted of 3,572 participants (mean age 74.96 ± 12.67) with ischemic stroke, who were consecutively admitted between 2003 and 2015. Patients were placed on one of three antiplatelet regimens at hospital discharge; aspirin monotherapy, aspirin plus dipyridamole and clopidogrel...
July 30, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/30064844/the-impact-of-foot-infection-on-infrainguinal-bypass-outcomes-in-patients-with-chronic-limb-threatening-ischemia
#16
Jessica M Mayor, Wilmer Valentin, Sherene Sharath, Neal R Barshes, Jayer Chung, Panos Kougias, Joseph L Mills
BACKGROUND: Despite advances in endovascular therapy, infrainguinal bypass continues to play a major role in achieving limb salvage. In this study, we sought to compare outcomes of infrainguinal bypass in patients with limb-threatening ischemia who presented with or without foot infection. METHODS: We conducted a retrospective cohort study of patients who underwent infrainguinal bypass for chronic limb-threatening ischemia at a single institution. End points of interest included long-term mortality, 45-day readmission, postoperative length of stay (LOS), major amputation, and time to wound healing...
July 28, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/30061570/two-common-mutations-within-cyp2c19-affected-platelet-aggregation-in-chinese-patients-undergoing-pci-a-one-year-follow-up-study
#17
Zhifu Wang, Zhaohui Liu, Wenyao Wang, Yuanyuan Fu, Wen Chen, Wenke Li, Xue Zhang, Yida Tang, Zhou Zhou
The effect of dual antiplatelet therapy, clopidogrel combined with aspirin, was influenced by CYP2C19 gene mutation and heterogeneity of population. Related studies remained controversial and limited, especially in Chinese. Total 3295 unrelated ACS Chinese patients undergoing percutaneous coronary intervention (PCI) were recruited and followed up to 1 year. Meanwhile, baseline and clinical data were retrieved. CYP2C19*2 and *3 were genotyped by sequencing. Associations of variants and metabolic types with platelet reactivity (PR) were analyzed by a logistic regression model...
July 31, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/30049366/coronary-angiography-and-revascularization-following-coronary-artery-bypass-grafting-in-british-columbia-incidence-predictors-and-longer-term-outcomes
#18
Peter T Moore, Christian Janssen, Aengus Murphy, Eric Fretz, Imad J Nadra, Anthony Della Siega, Simon D Robinson
BACKGROUND: Coronary artery bypass grafting (CABG) is established treatment for subsets of coronary artery disease (CAD). Observational data have characterised significant progression of native coronary as well as graft vessel disease during longer-term follow-up, potentially reducing the benefit of CABG. We sought to assess longer-term outcomes following CABG by determining rates of repeat coronary angiography, revascularization procedures, and survival. METHODS: Data for all patients undergoing isolated CABG in British Columbia between 2001 and 2009 inclusive, and with follow-up until the end of 2013, were retrieved from the British Columbia Cardiac Registry...
August 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/30034875/arachidonic-acid-in-health-and-disease-with-focus-on-hypertension-and-diabetes-mellitus-a-review
#19
REVIEW
Undurti N Das
Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important biological actions. Of all the actions, role of AA in the regulation of blood pressure and its ability to prevent both type 1 and type 2 diabetes mellitus seems to be interesting. Studies showed that AA and its metabolites especially, lipoxin A4 (LXA4) and epoxyeicosatrienoic acids (EETs), potent anti-inflammatory metabolites, have a crucial role in the pathobiology of hypertension and diabetes mellitus...
May 2018: Journal of Advanced Research
https://www.readbyqxmd.com/read/30029888/pre-diagnosis-and-post-diagnosis-use-of-common-analgesics-and-ovarian-cancer-prognosis-nhs-nhsii-a-cohort-study
#20
Melissa A Merritt, Megan S Rice, Mollie E Barnard, Susan E Hankinson, Ursula A Matulonis, Elizabeth M Poole, Shelley S Tworoger
BACKGROUND: Ovarian cancer is the fifth most common cause of cancer death among women in the USA. In this study, our objective was to determine whether modifiable exposures to common analgesics outside of standard treatment influence prognosis in patients with ovarian cancer. METHODS: The Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII) are ongoing prospective studies of 121 700 and 116 429 US nurses who have completed biennial questionnaires since 1976 and 1989, respectively...
August 2018: Lancet Oncology
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