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https://www.readbyqxmd.com/read/30015846/corosolic-acid-reduces-5%C3%A2-fu-chemoresistance-in-human-gastric-cancer-cells-by-activating-ampk
#1
Jun Beom Park, Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Soyeon Kim, Ji Young Sul
5‑Fluorouracil (5‑FU) is one of the most commonly used chemotherapeutic agents for gastric cancer. Resistance to 5‑FU‑based chemotherapy remains the major obstacle in the treatment of gastric cancer. A growing body of evidence has suggested that adenosine monophosphate‑activated protein kinase (AMPK) is pivotal for chemoresistance. However, the mechanism by which AMPK regulates the chemosensitivity of gastric cancer remains unclear. In the present study, how corosolic acid enhanced the chemosensitivity of gastric cancer cells to 5‑FU via AMPK activation was investigated...
July 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30014330/clinicopathological-characteristics-of-patients-with-pain-after-endoscopic-submucosal-dissection-for-gastric-epithelial-neoplasm
#2
Jung-Wook Kim, Jae-Young Jang, Yoo Min Park, Jae-Jun Shim, Young Woon Chang
BACKGROUND: Endoscopic submucosal dissection (ESD) is widely used for large superficial gastrointestinal tumors. Epigastric pain is a frequent complication of ESD. However, little is known about its incidence and associated factors. This study evaluated pain incidence and characteristics of patients with pain after gastric ESD. METHODS: We retrospectively analyzed a prospectively collected registry of clinical, endoscopic, and pathologic results of patients who underwent ESD for gastric adenoma or cancer from January 2010 to December 2015...
July 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30013197/comprehensive-molecular-characterization-of-clinical-responses-to-pd-1-inhibition-in-metastatic-gastric-cancer
#3
Seung Tae Kim, Razvan Cristescu, Adam J Bass, Kyoung-Mee Kim, Justin I Odegaard, Kyung Kim, Xiao Qiao Liu, Xinwei Sher, Hun Jung, Mijin Lee, Sujin Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Hyuk Lee, Mingew Choi, AmirAli Talasaz, Peter Soonmo Kang, Jonathan Cheng, Andrey Loboda, Jeeyun Lee, Won Ki Kang
Clinical studies support the efficacy of programmed cell death 1 (PD-1) targeted therapy in a subset of patients with metastatic gastric cancer (mGC). With the goal of identifying determinants of response, we performed molecular characterization of tissues and circulating tumor DNA (ctDNA) from 61 patients with mGC who were treated with pembrolizumab as salvage treatment in a prospective phase 2 clinical trial. In patients with microsatellite instability-high and Epstein-Barr virus-positive tumors, which are mutually exclusive, dramatic responses to pembrolizumab were observed (overall response rate (ORR) 85...
July 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/30008463/dietary-vitamin-d-intake-and-vitamin-d-related-genetic-polymorphisms-are-not-associated-with-gastric-cancer-in-a-hospital-based-case-control-study-in-korea
#4
Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, Sei-Jin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim
There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex...
July 12, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30008455/clinical-and-laboratory-characteristics-and-mortality-in-korean-patients-with-systemic-sclerosis-a-nationwide-multicenter-retrospective-cohort-study
#5
Ki Won Moon, Shin-Seok Lee, Yun Jong Lee, Jae-Bum Jun, Su-Jin Yoo, Ji Hyeon Ju, Sung Hae Chang, In Ah Choi, Tae Young Kang, Eun Bong Lee, Seung-Geun Lee
OBJECTIVE: We aimed to investigate demographic and clinical features and predictors of mortality in Korean patients with systemic sclerosis (SSc). METHODS: We performed a retrospective multicenter medical chart review in Korean patients diagnosed with SSc from 1986 to 2016 at 11 university hospitals representing each geographic area of Korea. SSc patients were defined according to the American College of Rheumatology preliminary classification criteria and subtyped as limited cutaneous (lcSSc) or diffuse cutaneous (dcSSc) SSc...
July 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/30006847/three-year-interval-for-endoscopic-screening-may-reduce-the-mortality-in-patients-with-gastric-cancer
#6
Sang Il Choi, Boram Park, Jungnam Joo, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Myeong-Cherl Kook, Soo-Jeong Cho
BACKGROUND: Endoscopic screening has been adopted in South Korea for the national screening of gastric cancer (GC). This study aimed to assess the effect on overall survival of GC patients and determine the optimal endoscopic screening interval. METHODS: The baseline characteristics and overall survival of GC patients treated at the National Cancer Center, Korea, between 2010 and 2016 were compared between those without a history of endoscopic evaluation (group N) and those in whom the interval between the last endoscopic evaluations and diagnosis of GC was ≤ 1, 1-2, 2-3, 3-4, or > 4 years (groups 1-5, respectively)...
July 13, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/30006689/young-age-and-risk-of-lymph-node-metastasis-in-differentiated-type-early-gastric-cancer
#7
Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Heejin Yoo, Kyunga Kim, Yoon-Ho Choi, Jae J Kim, Sung Kim
BACKGROUND: Young patients with gastric cancer reportedly have a worse prognosis than older patients due to delayed diagnosis and more aggressive tumor behavior. However, it is unclear whether this applies to early gastric cancer (EGC), for which endoscopic resection is indicated. We investigated the association between age and lymph node metastasis (LNM). METHODS: We identified 4055 patients diagnosed with EGC of differentiated histology who underwent surgery. The association between age and LNM was examined using logistic regression for each T stage separately with adjustments for multiple covariates...
July 13, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29984068/learning-curve-of-pure-single-port-laparoscopic-distal-gastrectomy-for-gastric-cancer
#8
Boram Lee, Yoon Taek Lee, Young Suk Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
Purpose: Despite the fact that there are several reports of single-port laparoscopic distal gastrectomy (SPDG), no analysis of its learning curve has been described in the literature. The aim of this study was to investigate the favorable factors for SPDG and to analyze the learning curve of SPDG. Materials and Methods: A total of 125 cases of SPDG performed from November 2011 to December 2015 were enrolled. All operations were performed by 2 surgeons (surgeon A and surgeon B)...
June 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29984064/modification-of-the-tnm-staging-system-for-stage-ii-iii-gastric-cancer-based-on-a-prognostic-single-patient-classifier-algorithm
#9
Yoon Young Choi, Eunji Jang, Won Jun Seo, Taeil Son, Hyoung-Il Kim, Hyeseon Kim, Woo Jin Hyung, Yong-Min Huh, Sung Hoon Noh, Jae-Ho Cheong
Purpose: The modification of the cancer classification system aimed to improve the classical anatomy-based tumor, node, metastasis (TNM) staging by considering tumor biology, which is associated with patient prognosis, because such information provides additional precision and flexibility. Materials and Methods: We previously developed an mRNA expression-based single patient classifier (SPC) algorithm that could predict the prognosis of patients with stage II/III gastric cancer...
June 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29981676/surgical-treatment-of-a-mucinous-cystic-neoplasm-in-a-young-female-patient-a-case-report
#10
Cristina Radu, Cezar Stroescu, Dragoş Chiriţă, Radu Poenaru, Adelina Birceanu, Narcis Copcă
The major challenge in the evaluation of pancreatic cystic neoplasms is identifying lesions with malignant potential or signs of malignancy. Overall, the risk of malignancy in incidentally detected pancreatic cysts is low. Pancreatic cystic neoplasms with malignant potential are: serous cystic tumors (SCTs), mucinous cystic neoplasms (MCNs), intraductal papillary mucinous neoplasms (IPMNs) and solid pseudopapillary neoplasms (SPNs). The risk for developing malignancy is very low for SCTs, moderate to high in MCNs, solid pseudopapillary tumors and some IPMNs (up to 70 percent for main-duct IPMNs)...
May 2018: Chirurgia
https://www.readbyqxmd.com/read/29948559/epstein-barr-virus-antibody-titers-are-not-associated-with-gastric-cancer-risk-in-east-asia
#11
Matthew G Varga, Hui Cai, Tim Waterboer, Gwen Murphy, Taichi Shimazu, Phil R Taylor, You-Lin Qiao, Sue K Park, Keun-Young Yoo, Sun Ha Jee, Eo Rin Cho, Jeongseon Kim, Christian C Abnet, Shoichiro Tsugane, Qiuyin Cai, Wei Zheng, Michael Pawlita, Xiao-Ou Shu, Meira Epplein
BACKGROUND: Epstein-Barr virus (EBV)-positive gastric cancers represent a distinct subtype of gastric cancers and account for nearly 10% of the gastric cancer burden, yet risk detection strategies for this cancer subtype are lacking. METHODS: We conducted a nested case-control study where we assayed 4 EBV antigens [viral capsid antigen (VCA), early antigen (EA), Epstein-Barr nuclear antigen (EBNA), and BZLF1-encoded replication activator protein (ZEBRA)] in either sera or plasma from 1447 gastric cancer cases and 1797 controls obtained from seven prospective cohorts representing individuals from the high gastric cancer-risk countries of China, Japan, and Korea...
June 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29948387/the-clinical-implications-of-fdg-pet-ct-differ-according-to-histology-in-advanced-gastric-cancer
#12
Hong Jae Chon, Chan Kim, Arthur Cho, Yoo Min Kim, Su Jin Jang, Bo Ok Kim, Chan Hyuk Park, Woo Jin Hyung, Joong Bae Ahn, Sung Hoon Noh, Mijin Yun, Sun Young Rha
BACKGROUND: The prognostic impact of preoperative 18 F-FDG PET/CT in advanced gastric cancer (AGC) remains a matter of debate. This study aims to evaluate the prognostic impact of SUVmax in preoperative 18 F-FDG PET/CT of AGC according to histologic subtype, with a focus on the differences between tubular adenocarcinoma and signet ring cell (SRC) carcinoma. METHODS: As a discovery set, a total of 727 AGC patients from prospective database were analyzed according to histologic subtype with Cox proportional hazard model and p-spline curves...
June 9, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29937185/prognostic-impact-of-extranodal-extension-in-stage-1b-gastric-carcinomas
#13
In-Seob Lee, Hyo Jeong Kang, Young-Soo Park, Min-Hee Ryu, Jeong-Hwan Yook, Yoon-Koo Kang, Byung-Sik Kim
BACKGROUND: In addition to the TNM stage, an additional prognostic factor is needed to assess the prognosis of gastric cancer. Moreover, there is no consensus on high-risk group of recurrence and adjuvant strategy in stage 1B gastric cancers. We aimed to investigate the prognostic significance of extranodal extension (ENE) in stage 1B gastric carcinomas and assess whether ENE can indicate the need for adjuvant treatment. METHODS: The clinicopathological characteristics of 1588 patients who underwent curative gastrectomy with more than D1 plus lymphadenectomy for stage 1B gastric cancer from 2003 to 2010 were reviewed...
June 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29936442/pregnancy-and-gastric-cancer-diagnostic-and-treatment-dilemma
#14
Nawar Hussain, Navaneethakrishnan Selvakumari, Frances Afadapa, Olubusola Amu
Gastric cancer in pregnancy is an extremely rare entity. The incidence of gastric cancer is more in elderly patients and higher in the male population. Gastric cancer symptoms can be nausea, vomiting and epigastric discomfort which is similar to early pregnancy symptoms. This leads to a misinterpretation and delay in the diagnosis during pregnancy. Gastric cancer in pregnancy is associated with poor prognosis because of its delayed diagnosis at an advance stage. We present our patient here, with this rare clinical diagnosis and with no suspicion in a young healthy woman...
June 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29928885/a-natural-compound-aristoyagonine-is-identified-as-a-potent-bromodomain-inhibitor-by-mid-throughput-screening
#15
Young Hun Kim, Minsung Kim, Miyoun Yoo, Ji Eun Kim, Heung Kyoung Lee, Jung-Nyoung Heo, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Chang-Soo Yun, Sung Woong Moon, Hye Kyung Chang, Chul-Woong Chung, Suhkneung Pyo, Sang Un Choi, Chi Hoon Park
Bromodomain-containing protein 4 (Brd4) is known to play a key role in tumorigenesis. It binds acetylated histones to regulate the expression of numerous genes. Because of the importance of brd4 in tumorigenesis, much research has been undertaken to develop brd4 inhibitors with therapeutic potential. As a result, various scaffolds for bromodomain inhibitors have been identified. To discover new scaffolds, we performed mid-throughput screening using two different enzyme assays, alpha-screen and ELISA. We found a novel bromodomain inhibitor with a unique scaffold, aristoyagonine...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928409/accumulation-of-t-helper-22-cells-interleukin-22-and-myeloid-derived-suppressor-cells-promotes-gastric-cancer-progression-in-elderly-patients
#16
Xuehua Chen, Yanfu Wang, Jiali Wang, Jinhui Wen, Xuzhao Jia, Xiaojun Wang, Hua Zhang
Chronic inflammation and immunosuppression lead to aging and tumorigenesis. T-helper 22 (Th22) cells, interleukin 22 (IL-22) and myeloid-derived suppressor cells (MDSCs) serve an important role in inflammatory-immune diseases and cancer. However, the status of Th22 cells, IL-22 and MDSCs in aging and elderly gastric cancer progression is unknown. In the present study, 39 elderly patients with gastric cancer (EGC), 32 elderly healthy controls (HE) and 31 young healthy controls (HY) were enrolled, and the peripheral Th22, Th17 and Th1 cells, and MDSCs, were examined using flow cytometry...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928208/complete-response-for-more-than-4-years-following-neoadjuvant-folfox-and-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-for-a-patient-with-advanced-gastric-cancer-with-extensive-peritoneal-carcinomatosis
#17
Renata D'Alpino Peixoto, Tercia Tarciane de Sousa, Pedro Alexandre Ismael Amaral Silva, Luciana Rodrigues de Meirelles, Carlos Henrique Andrade Teixeira
Background: Peritoneal carcinomatosis is usually a terminal disease with short median survival in patients with gastric cancer. Systemic FOLFOX is one of the most used regimens in the first-line treatment of metastatic gastric cancer. However, there is scarce evidence that cytoreductive surgery (CRS) and intraperitoneal heated chemotherapy (HIPEC) improves oncological outcomes of patients with advanced gastric cancer. Methods: Herein we present a case of a young woman with advanced gastric cancer with omental and peritoneal metastases who achieved an excellent response after 6 months of FOLFOX followed by CRS and HIPEC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29915987/roux-stasis-syndrome-and-gastric-food-stasis-after-laparoscopic-distal-gastrectomy-with-uncut-roux-en-y-reconstruction-in-gastric-cancer-patients-a-propensity-score-matching-analysis
#18
Young Suk Park, Dong Joon Shin, Sang-Yong Son, Ki-Hyun Kim, Dong Jin Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
BACKGROUND: Uncut Roux-en-Y gastrojejunostomy (uRYGJ) was developed to prevent slow peristalsis in the Roux limb after Roux-en-Y gastrojejunostomy (RYGJ). This study compared the incidence of Roux stasis syndrome (RSS) and severe gastric food stasis in gastric cancer patients who underwent RYGJ or uRYGJ after laparoscopic curative distal gastrectomy. METHODS: Between January 2006 and June 2012, 319 patients underwent RYGJ or uRYGJ. After covariates were adjusted by propensity score matching, 39 patients in the RYGJ group and 65 patients in the uRYGJ group were included in the final analysis...
June 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29915957/transcriptional-analysis-of-immune-genes-in-epstein-barr-virus-associated-gastric-cancer-and-association-with-clinical-outcomes
#19
Raghav Sundar, Aditi Qamra, Angie Lay Keng Tan, Shenli Zhang, Cedric Chuan Young Ng, Bin Tean Teh, Jeeyun Lee, Kyoung-Mee Kim, Patrick Tan
BACKGROUND: Epstein-Barr virus-associated gastric cancer (EBVaGC) has traditionally been associated with high expression of PD-L1 and immune infiltration. Correlations between PD-L1 and other immune-related gene (IRG) expressions in EBVaGC have not been previously described. METHODS: We performed NanoString® transcriptomic profiling and PD-L1 immunohistochemistry (IHC) (using the FDA approved Dako PD-L1 IHC 22C3) on EBVaGC samples from gastric cancer patients undergoing primary tumor resections at Samsung Medical Centre, South Korea...
June 18, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29898649/bpc157-as-potential-agent-rescuing-from-cancer-cachexia
#20
Eun A Kang, Young Min Han, Jeong Min An, Yong Jin Park, Predrag Sikiric, Deok Hwan Kim, Kwang An Kwon, Yoon Jae Kim, Donghwa Yang, Hann Tchah, Ki Baik Hahm
Cancer cachexia, one of the metabolic syndromes caused by cancer, is a devastating and miserable condition encountered in more than 50% of terminal cancer patients presenting with significant weight loss associated with skeletal muscle atrophy and fat loss. Though cachexia may account for up to 20% of cancer deaths, no significant treatment is still lacking and is of urgent unmet medical need in cancer treatment. Therefore, understanding the underlying molecular mechanisms is essential for anticipating therapeutic approaches...
June 13, 2018: Current Pharmaceutical Design
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