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Young gastric cancer

Chan Hyuk Park, Hyunki Kim, Jeong Hyeon Jo, Kyu Yeon Hahn, Jung-Ho Yoon, Soon Young Kim, Yong Chan Lee, Sung Hoon Noh, Hyun Cheol Chung, Sang Kil Lee
BACKGROUND: A high yield of biopsy is mandatory to perform molecular genetic research with endoscopically obtained gastric cancer tissues. We evaluated whether probe-based confocal laser endomicroscopy (pCLE) can increase the yield of endoscopic biopsy for gastric cancer compared with white light endoscopy (WLE). METHODS: All lesions in the pCLE and WLE groups were initially evaluated through WLE. In the pCLE group, lesions were further examined through pCLE. In the pilot study, five and three biopsy specimens were obtained for histopathological examination and tumor marker analysis, respectively...
September 17, 2018: Journal of Gastroenterology and Hepatology
Ho-Jae Lee, Young-Min Han, Jeong Min An, Eun A Kang, Yong Jin Park, Ji-Young Cha, Ki Baik Hahm
Although inflammation is defensive and healing process that maintains organ homeostasis, unresolved inflammation can lead to diseases. Polyunsaturated fatty acids (PUFAs), especially n-6 PUFAs abundant in Western diet, are precursors of pro-inflammatory mediators, whereas n-3 PUFAs possess anti-inflammatory properties. Therefore, interest in the cancer-preventive effect of n-3 PUFAs is increasing. Areas covered: We have observed significant reductions of gastrointestinal (GI) tumorigenesis in the Fat-1 transgenic mouse as evidenced that the decrease in Helicobacter pylori-infected gastric tumorigenesis, colon, biliary and pancreatic cancer was seen in Fat-1 mice producing n-3 PUFAs...
September 17, 2018: Expert Review of Anticancer Therapy
Boyoung Park, Sarah Yang, Jeonghee Lee, Hae Dong Woo, Il Ju Choi, Young Woo Kim, Keun Won Ryu, Young-Il Kim, Jeongseon Kim
Purpose: Half of the world's gastric cancer cases and the highest gastric cancer mortality rates are observed in Eastern Asia. Although several genome-wide association studies (GWASs) have revealed susceptibility genes associated with gastric cancer, no GWASs have been conducted in the Korean population, which has the highest incidence of gastric cancer. Materials and Methods: We performed genome scanning of 450 gastric cancer cases and 1,134 controls via Affymetrix Axiom Exome 319 arrays, followed by replication of 803 gastric cancer cases and 3,693 healthy controls...
September 5, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Myoung-Hee Kang, Hyunji Choi, Masanobu Oshima, Jae-Ho Cheong, Seokho Kim, Jung Hoon Lee, Young Soo Park, Hueng-Sik Choi, Mi-Na Kweon, Chan-Gi Pack, Ju-Seog Lee, Gordon B Mills, Seung-Jae Myung, Yun-Yong Park
The original version of this Article contained errors in Figs. 4, 5, and 6. In Fig. 4d, the x-axis label incorrectly read 'blank, +, blank, +', and in Fig. 5e, the bars of the second graph from the left were coloured blue-orange-blue-orange. Both of these errors have been fixed in the PDF and HTML versions of the Article. Furthermore, in Fig. 6a, the right-hand image of AGS cells treated with 5 µM DY131 was inadvertently replaced with a duplicate of the left-hand image. The correct version of this figure panel appears in the Author Correction associated with this Article...
August 31, 2018: Nature Communications
Kwangwoo Nam, Jeong Eun Shin, Sung Eun Kim, Gwang Ho Baik, Sang Hyeon Choi, Ju Yup Lee, Kyung Sik Park, Young-Eun Joo, Dae-Seong Myung, Hyeon Ju Kim, Hyun Joo Song, Suck Chei Choi, Hyun Jin Kim, Hyun Young Kim, Nayoung Kim
OBJECTIVES: The prevalence of upper gastrointestinal disease is expected to change following advances in socioeconomic status and improved hygiene in Korea. The aim of this study was to investigate the recent trends in upper gastrointestinal diseases based on endoscopic findings and Helicobacter pylori (H. pylori) seroprevalence in subjects undergoing health check-up at tertiary centers in Korea. METHODS: A multicenter cross-sectional study was conducted at nine healthcare centers between September 2016 and June 2017...
August 31, 2018: Scandinavian Journal of Gastroenterology
Dong-Wook Kim, Bosu Jeong, Il-Hyung Shin, Uk Kang, Yoontaek Lee, Young Suk Park, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim
BACKGROUND: The aim of this study was to evaluate the feasibility of indocyanine green (ICG) fluorescent method for sentinel lymph node detection in early gastric cancer. METHODS: Between December 2012 and December 2014, 28 cases of pilot examination were performed at Seoul National University Bundang Hospital. Advanced version of multispectral fluorescence organoscope was used to identify sentinel node by quantitative estimation of ICG fluorescent signal intensity...
August 27, 2018: Surgical Endoscopy
Jessica L Mueller, Danbee H Kim, Sahael Stapleton, Christy E Cauley, David C Chang, Cho Hyun Park, Kyo Young Song, John T Mullen
BACKGROUND: The prognosis of gastric cancer patients is better in Asia than in the West. Genetic, environmental, and treatment factors have all been implicated. We sought to explore the extent to which the place of birth and the place of treatment influences survival outcomes in Korean and US patients with localized gastric cancer. METHODS: Patients with localized gastric adenocarcinoma undergoing potentially curative gastrectomy from 1989 to 2010 were identified from the SEER registry and two single institution databases from the US and Korea...
August 22, 2018: Gastric Cancer
Tae Woo Kim, Seon Young Lee, Mia Kim, Chunhoo Cheon, Seong-Gyu Ko
Kaempferol, a flavonoid, found in traditional medicine, fruits, and vegetables, and an HDAC inhibitor, is a powerful anti-cancer reagent against various cancer cell lines. However, detailed mechanisms involved in the treatment of gastric cancer (GC) using kaempferol are not fully understood. In our study, we investigated the biological activity and molecular mechanism involved in kaempferol-mediated treatment of GC. Kaempferol promoted autophagy and cell death, and increased LC3-I to LC3-II conversion and the downregulation of p62 in GC...
August 29, 2018: Cell Death & Disease
Meira Epplein, Julia Butt, Yang Zhang, Laura H Hendrix, Christian C Abnet, Gwen Murphy, Wei Zheng, Xiao-Ou Shu, Shoichiro Tsugane, You-Lin Qiao, Philip R Taylor, Taichi Shimazu, Keun-Young Yoo, Sue K Park, Jeongseon Kim, Sun Ha Jee, Tim Waterboer, Michael Pawlita, Wei-Cheng You, Kai-Feng Pan
BACKGROUND: Helicobacter pylori is the leading cause of gastric cancer, yet the majority of infected individuals will not develop neoplasia. Previously we developed and replicated serologic H. pylori biomarkers for gastric cancer risk among prospective cohorts in East Asia, and now seek to validate the performance of these biomarkers in identifying individuals with premalignant lesions. METHODS: This cross-sectional study included 1,402 individuals from Linqu County screened by upper endoscopy...
August 29, 2018: Cancer Epidemiology, Biomarkers & Prevention
Han Hong Lee, Su Young Kim, Eun Sun Jung, Jinseon Yoo, Tae-Min Kim
BACKGROUND: The acquisition of an invasive phenotype by a tumor cell is a crucial step of malignant transformation. The underlying genetic mechanisms in gastric cancer (GC) are not well understood. METHODS: We performed whole-exome sequencing of 15 pairs of primary GC and their matched lymph node (LN) metastases (10 primary GCs with single matched LNs and 5 primary GCs with three LNs per case, respectively). Somatic alterations including single nucleotide variations, short insertions/deletions including locus-level microsatellite instability and copy number alterations were identified and compared between the primary and metastatic LN genomes...
August 21, 2018: Gastric Cancer
Woo Jin Hyung, Han-Kwang Yang, Sang-Uk Han, Young-Jun Lee, Joong-Min Park, Jin Jo Kim, Oh Kyung Kwon, Seong Ho Kong, Hyoung-Il Kim, Hyuk-Joon Lee, Wook Kim, Seung Wan Ryu, Sung-Ho Jin, Sung Jin Oh, Keun Won Ryu, Min-Chan Kim, Hye-Seong Ahn, Young Kyu Park, Young-Ho Kim, Sun-Hwi Hwang, Jong Won Kim, Gyu Seok Cho
BACKGROUND: With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer. METHODS: Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled...
August 20, 2018: Gastric Cancer
Keun-Wook Lee, Chi Hoon Maeng, Tae-You Kim, Dae Young Zang, Yeul Hong Kim, In Gyu Hwang, Sang Cheul Oh, Joo Seop Chung, Hong Suk Song, Jin Won Kim, Su Jin Jeong, Jae Yong Cho
LESSONS LEARNED: Irinotecan could not be proven noninferior to paclitaxel as a second-line treatment for patients with metastatic or recurrent gastric cancer.The failure to demonstrate noninferiority may have been a result of insufficient patient enrollment.Both agents were tolerable but showed different toxicity profiles. BACKGROUND: This phase III study compared the efficacy and safety of paclitaxel versus irinotecan in patients with metastatic or recurrent gastric cancer (MRGC) who had experienced disease progression following first-line chemotherapy...
August 20, 2018: Oncologist
Jong Soo Lee, Young Saing Kim, Eun Young Kim, Wook Jin
BACKGROUND: Sarcopenia, defined as decreased skeletal muscle mass, is prevalent and associated with poor prognosis in various solid tumors. This study aimed to determine the prognostic role of sarcopenia in patients with advanced gastric cancer (AGC). METHODS: This retrospective study consisted of 140 consecutive patients who underwent palliative chemotherapy for AGC. A cross-sectional area of muscle at the level of the third lumbar vertebra (L3) was measured using baseline computed tomography (CT) scans...
2018: PloS One
Małgorzata Pucułek, Julita Machlowska, Ryszard Wierzbicki, Jacek Baj, Ryszard Maciejewski, Robert Sitarz
Nowadays, gastric cancer is one of the most common neoplasms and the fourth cause of cancer-related death on the world. Regarding the age at the diagnosis it is divided into early-onset gastric carcinoma (45 years or younger) and conventional gastric cancer (older than 45). Gastric carcinomas are rarely observed in young population and rely mostly on genetic factors, therefore provide the unique model to study genetic and environmental alternations. The latest research on early-onset gastric cancer are trying to explain molecular and genetic basis, because young patients are less exposed to environmental factors predisposing to cancer...
July 24, 2018: Oncotarget
Soo-Jeong Cho, Changhwan Yoon, Jun-Ho Lee, Kevin K Chang, Jian-Xian Lin, Young Ho Kim, Myeong-Cherl Kook, Bülent A Aksoy, Do Joong Park, Hassan Ashktorab, Duane Smoot, Nikolaus Schultz, Sam S Yoon
PURPOSE: Lauren diffuse type gastric adenocarcinoma (DGA) is genomically stable. We identified lysine (K)-specific methyltransferase 2C ( KMT2C ) as a frequently mutated gene and examined its role in DGA progression. EXPERIMENTAL DESIGN AND RESULTS: Whole exome sequencing on tumor samples of 27 patients with DGA who underwent gastrectomy and identified lysine (K)-specific methyltransferase 2C ( KMT2C ) as mutated in 11 of 27 tumors (41%). This high frequency of KMT2C mutations in DGA has not been found in prior studies...
August 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Feng Li, Janice M Yoshizawa, Kyoung-Mee Kim, Julie Kanjanapangka, Tristan R Grogan, Xiaoyan Wang, David E Elashoff, Shigeo Ishikawa, David Chia, Wei Liao, David Akin, Xinmin Yan, Min-Sun Lee, Rayun Choi, Su-Mi Kim, So-Young Kang, Jae-Moon Bae, Tae-Sung Sohn, Jun-Ho Lee, Min-Gew Choi, Byung-Hoon Min, Jun-Haeng Lee, Jae J Kim, Yong Kim, Sung Kim, David T W Wong
BACKGROUND: Biomarkers are needed for noninvasive early detection of gastric cancer (GC). We investigated salivary extracellular RNA (exRNA) biomarkers as potential clinical evaluation tools for GC. METHODS: Unstimulated whole saliva samples were prospectively collected from 294 individuals (163 GC and 131 non-GC patients) who underwent endoscopic evaluation at the Samsung Medical Center in Korea. Salivary transcriptomes of 63 GC and 31 non-GC patients were profiled, and mRNA biomarker candidates were verified with reverse transcription quantitative real-time PCR (RT-qPCR)...
August 10, 2018: Clinical Chemistry
Jisun Lim, Moon-Won Yoo, Seo Young Kang, Hye Soon Park
BACKGROUND: With the increase in the prevalence of overweight, percentage of overweight patients with gastric cancer has also increased. This 5-year retrospective cohort study was performed to investigate long-term changes in the metabolic and nutritional parameters of early gastric cancer (EGC) patients with overweight after gastrectomy. METHODS: EGC patients who underwent gastrectomy were followed up over a 5-year period. We included 393 patients (261 men, 132 women) who had an initial body mass index (BMI) of ≥23 kg/m2 , and analyzed the longitudinal changes in the metabolic and nutritional parameters...
August 7, 2018: Asian Journal of Surgery
Hariti Saluja, Christos S Karapetis, Susanne K Pedersen, Graeme P Young, Erin L Symonds
Gastrointestinal cancers, including oesophageal, gastric and colorectal cancers (CRC) have high rates of disease recurrence despite curative resection. There are a number of recent studies that have investigated the use of circulating tumor DNA (ctDNA) for prognostic value in these cancers. We reviewed studies that had been published prior to March 2018 that assessed the prognostic values of ctDNA in patients with oesophageal and gastric cancers, gastrointestinal stromal tumors (GIST) and CRC. We identified 63 eligible clinical studies that focussed on recurrence and survival...
2018: Frontiers in Oncology
Ji Hyun Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Oran Kwon, Hyesook Kim, Jeongseon Kim
Although the incidence of gastric cancer (GC) has declined, it remains the second most common cancer in Korea. As a class of phytochemicals, carotenoids are fat-soluble pigments that are abundant in fruits and vegetables and have health-promoting properties, including cancer prevention effects. This case-control study investigated the effects of total dietary carotenoids, dietary carotenoid subclasses (α-carotene, β-carotene, β-cryptoxanthin, lutein/zeaxanthin, and lycopene), and foods contributing to the dietary intake of each carotenoid on the risk of GC...
August 7, 2018: Nutrients
Gi Hyeon Seo, Chang-Sup Lim, Young Jun Chai
Purpose: Gallstone formation is one of the most common problems after gastrectomy. This retrospective cohort study used the South Korean nationwide claims database to evaluate the incidence and risk factors of gallstone after gastrectomy for gastric cancer. Methods: All consecutive patients who underwent gastrectomy for gastric cancer in South Korea in 2008-2010 were identified. Incidence of gallstone formation 5 years after gastrectomy in males and females, in various age groups, and after different types of gastrectomy was determined...
August 2018: Annals of Surgical Treatment and Research
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