keyword
MENU ▼
Read by QxMD icon Read
search

Young gastric cancer

keyword
https://www.readbyqxmd.com/read/27904851/validation-of-the-7th-ajcc-uicc-staging-system-for-gastric-cancer-and-a-proposal-for-a-new-tnm-system-based-on-a-prognostic-score-a-retrospective-multicenter-study
#1
Oh Kyoung Kwon, Se Won Kim, Hyun-Dong Chae, Seung Wan Ryu, Ho Young Chung, Sang Woon Kim, Won Kee Lee, Wansik Yu
PURPOSE: We validate the 7th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system for gastric cancer and propose a new staging system that reflects the prognostic significances of each of T and N category. METHODS: Data from 5,957 patients who underwent curative gastrectomies from 2000 to 2007 at 4 university hospitals in Daegu Metropolitan city in Korea were analyzed for the validation of the 7th AJCC/UICC staging system for gastric cancer...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27895802/vitamin-c-induces-apoptosis-in-ags-cells-via-production-of-ros-of-mitochondria
#2
Jae Young Lim, Donghyun Kim, Bok Ran Kim, Jin Su Jun, Jung Sook Yeom, Ji Sook Park, Ji-Hyun Seo, Chan Hoo Park, Hyang Ok Woo, Hee-Shang Youn, Seung-Chul Baik, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee
It has been demonstrated that vitamin C exhibits anti-cancer activity in various tumor cell lines; however, its specific mechanism of action remains unknown. Although the diagnosis and therapy of cancer patients have markedly improved in recent years, safer and more cost-effective treatments are still required. Therefore, the present study examined the effect of vitamin C on the induction of cell death in gastric cancer and its underlying mechanism of action. It was observed that the cytotoxicity of vitamin C on the human gastric cancer cell line AGS is dependent on the apoptotic pathway, including caspase cascades, but not on the necroptotic pathway...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895401/her2-induced-metastasis-is-mediated-by-akt-jnk-emt-signaling-pathway-in-gastric-cancer
#3
Yiseul Choi, Young San Ko, Jinju Park, Youngsun Choi, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Douk Ho Hwang, Woo Ho Kim, Byung Lan Lee
AIM: To investigated the relationships between HER2, c-Jun N-terminal kinase (JNK) and protein kinase B (AKT) with respect to metastatic potential of HER2-positive gastric cancer (GC) cells. METHODS: Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27882418/compliance-with-guidelines-of-enhanced-recovery-after-surgery-in-elderly-patients-undergoing-gastrectomy
#4
Oh Jeong, Young Kyu Park, Mi Ran Jung, Seong Yeob Ryu
BACKGROUND: Enhanced recovery after surgery (ERAS) aims at expediting postoperative recovery by implementing specific strategies in perioperative management. However, the tolerance to such fast-tracking protocols is under debate, especially in elderly patients. We aimed to investigate rate of compliance with the main ERAS guidelines in elderly gastrectomy patients. METHODS: Using data for 168 gastric cancer patients who underwent ERAS after gastrectomy as part of Clinical Trial NCT01653496, we calculated the rates of compliance with nine main ERAS guidelines and compared the compliance rates of elderly (≥70 years) and non-elderly (<70 years) patients...
November 23, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27878584/altered-intrinsic-brain-activity-after-chemotherapy-in-patients-with-gastric-cancer-a-preliminary-study
#5
Hyun Gi Kim, Na-Young Shin, Yunjin Bak, Kyung Ran Kim, Young-Chul Jung, Kyunghwa Han, Seung-Koo Lee, Soo Mee Lim
OBJECTIVES: To characterize the pattern of altered intrinsic brain activity in gastric cancer patients after chemotherapy (CTx). METHODS: Patients before and after CTx (n = 14) and control subjects (n = 11) underwent resting-state functional MRI (rsfMRI) at baseline and 3 months after CTx. Regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF), and fractional ALFF (fALFF) were calculated and compared between the groups using the two-sample t test...
November 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27871160/clinical-outcome-of-doublet-and-triplet-neoadjuvant-chemotherapy-for-locally-advanced-gastric-cancer
#6
Ju Seok Kim, Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong, Ji Young Sul
Background/Aims: In gastric cancer, the rate of recurrence and metastasis following radical resection is high, necessitating improvement in survival and cure rates. Neoadjuvant chemotherapy (NAC) has potential benefits for locally advanced gastric cancer; however, the surgical benefits and effects on survival are unclear. This study evaluates the effectiveness of NAC in locally advanced gastric cancer and compares clinical outcomes of doublet and triplet regimens. Methods: We reviewed patient medical records of 383 patients who underwent NAC (n=41) or surgery only (n=342) for treatment of locally advanced gastric cancer...
November 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27863404/kallikrein-related-peptidase-6-induces-chemotherapeutic-resistance-by-attenuating-auranofin-induced-cell-death-through-activation-of-autophagy-in-gastric-cancer
#7
Tae Woo Kim, Seon-Jin Lee, Jong-Tae Kim, Sun Jung Kim, Jeong-Ki Min, Kwang-Hee Bae, Haiyoung Jung, Bo-Yeon Kim, Jong-Seok Lim, Young Yang, Do-Young Yoon, Yong-Kyung Choe, Hee Gu Lee
Kallikrein-related peptidase 6 (KLK6) is a biomarker of gastric cancer associated with poor prognosis. Mechanisms by which KLK6 could be exploited for chemotherapeutic use are unclear. We evaluated auranofin (AF), a compound with cytotoxic effects, in KLK6-deficient cells, and we investigated whether KLK6 expression induces autophagy and acquisition of drug resistance in gastric cancer. Using cultured human cells and a mouse xenograft model, we investigated how KLK6 affects antitumor-reagent-induced cell death and autophagy...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27858920/clinical-risk-assessment-for-gastric-cancer-in-asymptomatic-population-after-a-health-check-up-an-individualized-consideration-of-the-risk-factors
#8
Yoo Mi Park, Jie-Hyun Kim, Su Jung Baik, Jae Jun Park, Young Hoon Youn, Hyojin Park
For the prevention of gastric cancer, the detection of risk factors associated with precancerous conditions may be more informative. The aim of this study was to identify the risk factors of gastric cancer, including precancerous conditions: atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.The clinical and endoscopic findings of 60,261 adults who underwent gastroduodenoscopy as part of a health check-up were reviewed retrospectively. Subgroup analysis was conducted according to age, sex, cancer stage, and histology based on Lauren classification...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858181/intratumor-stromal-proportion-predicts-aggressive-phenotype-of-gastric-signet-ring-cell-carcinomas
#9
Dakeun Lee, In-Hye Ham, Sang Yong Son, Sang-Uk Han, Young-Bae Kim, Hoon Hur
OBJECTIVE: The aim of this study was to evaluate the prognostic significance of the intratumor stromal proportion in gastric signet ring cell (SRC) carcinomas. BACKGROUND: Cancer stroma, as exemplified by cancer-associated fibroblasts (CAFs), plays critical roles in cancer proliferation, invasion, and metastasis. METHODS: One hundred seventy-five SRC carcinoma cases were classified according to the intratumor desmoplastic stromal proportion to then analyze the clinicopathologic characteristics of stroma-rich cases...
November 17, 2016: Gastric Cancer
https://www.readbyqxmd.com/read/27835650/zhx1-promotes-the-proliferation-migration-and-invasion-of-cholangiocarcinoma-cells
#10
Ryuk-Jun Kwon, Myoung-Eun Han, Ji-Young Kim, Liangwen Liu, Yun-Hak Kim, Jin-Sup Jung, Sae-Ock Oh
Zinc-fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been associated with the progressions of hepatocellular carcinoma, gastric cancer, and breast cancer. However, the functional roles of ZHX1 in cholangiocarcinoma (CCA) have not been determined. We investigated the expression and roles of ZHX1 during the proliferation, migration, and invasion of CCA cells. In silico analysis and immunohistochemical studies showed amplification and overexpression of ZHX1 in CCA tissues. Furthermore, ZHX1 knockdown using specific siRNAs decreased CCA cell proliferation, migration, and invasion, whereas ZHX1 overexpression promoted all three characteristics...
2016: PloS One
https://www.readbyqxmd.com/read/27830389/impact-of-the-cross-sectional-location-of-multidetector-computed-tomography-scans-on-prediction-of-serosal-exposure-in-patients-with-advanced-gastric-cancer
#11
Su Lim Lee, Young Mi Ku, Hae Myung Jeon, Han Hong Lee
BACKGROUND: The extent of serosal exposure varies depending on the cross-section of the stomach that is viewed, affected by the visceral peritoneum of the omentum. Although multidetector computed tomography (MDCT) is the most useful method to predict serosal exposure, the MDCT criteria for such exposure by cross-sectional location remain to be established. METHODS: The MDCT of gastric cancer patients who underwent surgery, and for whom pathological reports were available, were reviewed by radiologists...
November 9, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27810404/in%C3%A2-vivo-targeting-of-c-met-using-a-non-standard-macrocyclic-peptide-in-gastric-carcinoma
#12
Do Won Hwang, Namryeong Bahng, Kenichiro Ito, Seunggyun Ha, Mee Young Kim, Eunji Lee, Hiroaki Suga, Dong Soo Lee
Development of c-Met targeting probes based on specifically designed peptides with high affinity and stability could help enhance diagnostic efficacy and therapeutic effects in c-Met positive cancers. The Random non-standard Peptides Integrated Discovery (RaPID) system for synthesizing natural product-like macrocyclic peptides via in vitro translation-based selection has recently emerged to overcome the shortcomings of traditional peptide synthesis. Here, we developed non-standard macrocyclic peptides specific to c-Met, and examined the cancer-targeting efficiency of fluorescein-labeled (FL) anti-c-Met peptides, referred to as aML5-FL and aMD4-FL, both in vitro and in vivo...
October 31, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27806312/systematic-approach-identifies-rhoa-as-a-potential-biomarker-therapeutic-target-for-asian-gastric-cancer
#13
Hae Ryung Chang, Seungyoon Nam, Jinhyuk Lee, Jin-Hee Kim, Hae Rim Jung, Hee Seo Park, Sungjin Park, Young Zoo Ahn, Iksoo Huh, Curt Balch, Ja-Lok Ku, Garth Powis, Taesung Park, Jin-Hyun Jeong, Yon Hui Kim
Gastric cancer (GC) is a highly heterogeneous disease, in dire need of specific, biomarker-driven cancer therapies. While the accumulation of cancer "Big Data" has propelled the search for novel molecular targets for GC, its specific subpathway and cellular functions vary from patient to patient. In particular, mutations in the small GTPase gene RHOA have been identified in recent genome-wide sequencing of GC tumors. Moreover, protein overexpression of RHOA was reported in Chinese populations, while RHOA mutations were found in Caucasian GC tumors...
October 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27804041/erratum-to-c-reactive-protein-can-be-an-early-predictor-of-postoperative-complications-after-gastrectomy-for-gastric-cancer
#14
Eun Young Kim, Hyun Woo Yim, Cho Hyun Park, Kyo Young Song
No abstract text is available yet for this article.
November 1, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27802183/prognostic-impact-of-fibroblast-growth-factor-receptor-2-gene-amplification-in-patients-receiving-fluoropyrimidine-and-platinum-chemotherapy-for-metastatic-and-locally-advanced-unresectable-gastric-cancers
#15
Seyoung Seo, Seong Joon Park, Min-Hee Ryu, Sook Ryun Park, Baek-Yeol Ryoo, Young Soo Park, Young-Soon Na, Chae-Won Lee, Ju-Kyung Lee, Yoon-Koo Kang
Although Fibroblast growth factor receptor (FGFR) 2 gene amplification and its prognostic significance have been reported in resectable gastric cancers, information on these features remains limited in the metastatic setting. The presence of FGFR2 amplification was assessed in formalin-fixed, paraffin-embedded tissues using a quantitative PCR-based gene copy number assay with advanced gastric cancer cohorts. A total of 327 patients with tumor portion of ≥70% were analyzed for clinical features. Among these patients, 260 who received first-line fluoropyrimidine and platinum chemotherapy were analyzed for survival...
October 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27783407/efficient-pkc-inhibitor-screening-achieved-using-a-quantitative-ce-lif-assay
#16
Binh Thanh Nguyen, Min Park, Jae-Chul Pyun, Young Sook Yoo, Min-Jung Kang
An assay for protein kinase C delta (PKCδ) activity based on the quantification of a synthetic substrate using capillary electrophoresis with laser-induced fluorescence detection was developed. The peptides labeled with fluorescein isothiocyanate F-ERK (where ERK is extracellular signal-regulated kinase) and the phosphorylated form, P-F-ERK, were utilized for the method development and validation. The migration time of F-ERK and P-F-ERK were 6.3 ± 0.1 and 8.7 ± 0.2 min, respectively. LOD and LOQ values of F-ERK were 2 and 6 ng/mL and those of P-F-ERK were 4 and 12 ng/mL...
October 26, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27782889/clinical-outcomes-of-endoscopic-surveillance-for-gastric-ulcers-in-populations-with-a-high-prevalence-of-gastric-cancer
#17
Young Bae Lee, Jaeho Han, Jeong Hyeon Cho, Hong Sub Lee
BACKGROUND/AIMS: Although surveillance endoscopy is recommended after the treatment of a benign gastric ulcer in Korea, improved survival, secondary to an endoscopic follow-up strategy, is controversial. Thus, the aim of this study was to understand the results of gastric ulcer surveillance endoscopy and to individualize surveillance endoscopy by analyzing known risk factors for gastric cancer. MATERIALS AND METHODS: In total, 599 (M:F=424:175, median age=55.4 years) patients who were diagnosed with a gastric ulcer and who underwent follow-up endoscopy between January 2003 and August 2014 were retrospectively enrolled in this study...
September 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27780943/the-prevalence-of-colonic-neoplasm-in-cryptogenic-pyogenic-liver-abscess-a-prospectively-enrolled-cross-sectional-study
#18
Nae Yun Heo, Young Mi Hong, Tae Oh Kim, Young Soo Moon, Sung Yeun Yang, Seung Ha Park, Jongha Park, Joon Hyuk Choi, Sung Min Kim, Ki Tae Yoon, Mong Cho, Minkyung Oh
Background/Aims: Several studies suggest that pyogenic liver abscess (PLA) is associated with colon neoplasm. A colonoscopic exam for cryptogenic PLA might detect a hidden colon neoplasm, through which intestinal flora can be transmitted into the liver. However, there are no prospectively enrolled cross-sectional data for colonic neoplasm in cryptogenic PLA. Methods: Patients with PLA were prospectively enrolled from two university hospitals. Among them, all the patients with cryptogenic PLA were recommended for colonoscopic exam to check for colonic neoplasm...
October 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27777899/helicobacter-pylori-infection-is-associated-with-decreased-expression-of-slc5a8-a-cancer-suppressor-gene-in-young-children
#19
Andrea Orellana-Manzano, Miguel G O'Ryan, Anne J Lagomarcino, Sergio George, Mindy S Muñoz, Nora Mamani, Carolina A Serrano, Paul R Harris, Octavio Ramilo, Asunción Mejías, Juan P Torres, Yalda Lucero, Andrew F G Quest
Background:Helicobacter pylori infects half of the world's population and causes gastric cancer in a subset of infected adults. Previous blood microarray findings showed that apparently healthy children, persistently infected with H. pylori have differential gene expression compared to age-matched, non-infected children. SLC5A8, a cancer suppressor gene with decreased expression among infected children, was chosen for further study based on bioinformatics analysis. Methods: A pilot study was conducted using specific qRT-PCR amplification of SLC5A8 in blood samples from H...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27771821/potentially-harmful-elements-in-house-dust-from-estarreja-portugal-characterization-and-genotoxicity-of-the-bioaccessible-fraction
#20
Sophie Plumejeaud, Amelia Paula Reis, Virginie Tassistro, Carla Patinha, Yves Noack, Thierry Orsière
Due to their behavioral characteristics, young children are vulnerable to the ingestion of indoor dust, often contaminated with chemicals that are potentially harmful. Exposure to potentially harmful elements (PHEs) is currently exacerbated by their widespread use in several industrial, agricultural, domestic and technological applications. PHEs cause adverse health effects on immune and nervous systems and can lead to cancer development via genotoxic mechanisms. The present study is an integrated approach that aims at assessing the genotoxicity of bioaccessible PHEs following ingestion of contaminated house dust...
October 22, 2016: Environmental Geochemistry and Health
keyword
keyword
110472
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"