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Young gastric cancer

Seung-Hoon Beom, Yoon Young Choi, Song-Ee Baek, Shuang-Xi Li, Joon Seok Lim, Taeil Son, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Seung Ho Choi, Minkyu Jung, Hyo Song Kim, Hei-Cheul Jeung, Hyun Cheol Chung, Sun Young Rha, Sung Hoon Noh
BACKGROUND: With advances in gastric cancer chemotherapy, conversion surgery has drawn attention as a new strategy to improve the outcome of stage IV disease. We investigated the efficacy of conversion surgery following chemotherapy for patients with stage IV gastric cancer. METHODS: We retrospectively reviewed clinico-pathologic variables and oncologic outcomes for 101 patients with stage IV gastric cancer who were treated with systemic chemotherapy followed by gastrectomy with intension of curative resection from January 2005 to December 2012...
November 15, 2018: BMC Cancer
Dae Hwa Park, Hee Seok Moon, Ji Young Sul, In Sun Kwon, Gee Young Yun, Seo Hee Lee, Jae Ho Park, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
In this study, we evaluate the usefulness of preoperative endoscopic clipping for early gastric cancer (EGC) localization in laparoscopic distal gastrectomy.We retrospectively screened all consecutive patients who underwent laparoscopic distal gastrectomy for EGC by 1 surgeon at Chungnam National University Hospital between January 2014 and December 2016. Patients who underwent combined surgery and patients who had tumors at the lower third of the stomach were excluded. Endoscopic clipping was performed prior to surgery by specialized endoscopists...
November 2018: Medicine (Baltimore)
Hyun Myong Kim, Inhye Jeong, Hyun Jeong Kim, Sun Kyoung Kang, Woo Sun Kwon, Tae Soo Kim, Kyu Hyun Park, Minkyu Jung, John Soong, Shu-Chuan Lin, Hyun Cheol Chung, Sun Young Rha
BACKGROUND/AIM: Casein kinase 2 (CK2) is involved in multiple cellular processes. Furthermore, its overexpression in several human cancers has been associated with tumor progression. In this study, we evaluated the efficacy of the CK2 inhibitor, CX-4945, in gastric cancer cell lines and explored the potential predictive biomarkers for CX-4945 sensitivity. MATERIALS AND METHODS: The sensitivity to CX-4945 was screened in 49 gastric cancer cell lines by the MTT assay...
November 2018: Anticancer Research
Su Jung Kim, Joon Won Lee, Hye Young Kang, So Young Kim, Yeon Kyeong Shin, Kwang Woo Kim, Jun Seok Oh, Ki Jung Lim, Ji Young Kim
BACKGROUND: CT-P6 is a biosimilar of trastuzumab, a monoclonal antibody targeting human epidermal growth factor 2 (HER2), that is used in the treatment of breast and gastric cancers. OBJECTIVE: The aim of this study was to evaluate the in-use physicochemical and biological stability of CT-P6 following preparation for intravenous (IV) infusion. METHODS: One batch of CT-P6 within the final month of its 48-month shelf life was used to simulate sub-optimal administration conditions...
November 2, 2018: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Seyoung Seo, Min-Hee Ryu, Young Soo Park, Ji Yong Ahn, Yangsoon Park, Sook Ryun Park, Baek-Yeol Ryoo, Gin Hyug Lee, Hwoon-Young Jung, Yoon-Koo Kang
BACKGROUND: Although discordance in HER2 positivity between primary and metastatic lesions is well established, changes in HER2 positivity after anti-HER2 therapy have not been well evaluated in gastric cancer. We aimed to evaluate whether HER2 expression in gastric cancer is affected by trastuzumab therapy. METHODS: We enrolled 48 HER2-positive advanced gastric cancer patients treated with trastuzumab-containing first-line chemotherapy and had paired biopsies at baseline and after progression...
November 1, 2018: Gastric Cancer
Gemma N Jones, Claire Rooney, Nicola Griffin, Martine Roudier, Lucy A Young, Antonio Garcia-Trinidad, Gareth D Hughes, Jeffrey R Whiteaker, Zena Wilson, Rajesh Odedra, Lei Zhao, Richard G Ivey, William J Howat, Elizabeth A Harrington, J Carl Barrett, Antonio Ramos-Montoya, Alan Lau, Amanda G Paulovich, Elaine B Cadogan, Andrew J Pierce
BACKGROUND: AZD0156 and AZD6738 are potent and selective inhibitors of ataxia-telangiectasia-kinase (ATM) and ataxia-telangiectasia-mutated and Rad3-related (ATR), respectively, important sensors/signallers of DNA damage. METHODS: We used multiplexed targeted-mass-spectrometry to select pRAD50(Ser635) as a pharmacodynamic biomarker for AZD0156-mediated ATM inhibition from a panel of 45 peptides, then developed and tested a clinically applicable immunohistochemistry assay for pRAD50(Ser635) detection in FFPE tissue...
November 2, 2018: British Journal of Cancer
Sun Hyung Kang, Hee Seok Moon, Jae Kyu Sung, Hyun Yong Jeong, Sae Hee Kim, Ki Bae Kim, Sei Jin Youn, Sun Moon Kim, Kyung Ho Song, Seung Woo Lee, Dong Soo Lee, Young Sin Cho, Il Kwun Chung, Ki Bae Bang
INTRODUCTION: Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Recent studies imply that early gastric SRC can be well managed by endoscopic resection. Unfortunately, unlike differentiated cancers, the endoscopic features of early gastric SRC have not been well studied. This study evaluated the endoscopic features of early gastric SRC, as well as the risk factors for submucosal (SM) invasion. METHOD: The medical records of patients from 7 tertiary hospitals (Daejeon and Chungcheong province) were reviewed to examine endoscopic findings and clinical data...
November 1, 2018: Digestive Diseases
Joo Young Ha, Song Ee Park, Hee Sung Kim, Hoyoun Won, Beom Jin Kim, In Gyu Hwang
RATIONALE: Merkel cell carcinoma (MCC) is an aggressive, rare neuroendocrine skin cancer. MCC metastasis to the heart is exceedingly rare and gastric metastases from MCC have rarely been reported. PATIENT CONCERNS: We described the case of an 82-year-old man diagnosed with recurrent MCC with cardiac and gastric metastasis who presented with poor oral intake and severe weight loss. The patient was diagnosed with MCC 3 years ago and treated with surgical resection and radiation...
November 2018: Medicine (Baltimore)
Seon Woo Lee, Do Youn Park, Mi-Young Kim, Changwon Kang
BACKGROUND: For an epigenetic regulation of human genome, three enzymes write or erase methylation of lysine-27 residue on histone H3 (H3K27me). This methylation is catalyzed by EZH2 (KMT6A) methyltransferase and reversed by KDM6A (UTX) or KDM6B (JMJD3) demethylase. Genetic cancer risk association has been reported on EZH2, but not on KDM6A or KDM6B yet. METHODS: A total of 23 tag single-nucleotide polymorphisms (SNPs) of the three genes were genotyped in 2349 Korean participants, and their gastric cancer risk associations and epistases were statistically examined by comparing the SNP genotypes of 1100 gastric cancer patients and 1249 healthy controls...
October 29, 2018: Gastric Cancer
Yoshiyasu Kono, Hiromitsu Kanzaki, Takao Tsuzuki, Masahiro Takatani, Junichirou Nasu, Daisuke Kawai, Ryuta Takenaka, Takehiro Tanaka, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Toshiyoshi Fujiwara, Hiroyuki Okada
BACKGROUND: The details of gastric cancer in young patients remain unclear because of the low prevalence of the disease. This study aimed to clarify the clinicopathological features and prognosis of gastric cancer in young patients. METHODS: From January 2007 to January 2016, patients in their 20s and 30s who were diagnosed with primary gastric cancer at 4 hospitals were enrolled. Their clinical characteristics and prognosis were evaluated. RESULTS: The total number of patients was 72...
October 29, 2018: Journal of Gastroenterology
Quetzalihuitl Arroyo-Martinez, Won Ho Han, Bang Wool Eom, Hong Man Yoon, Young Il Kim, Soo Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Salvador Morales-Conde, Javier Padillo-Ruiz, Myeong-Cherl Kook, Il Ju Choi, Young Woo Kim, Keun Won Ryu
BACKGROUND AND OBJECTIVES: Additional surgery should be done after non-curative endoscopic resection (ER) in early gastric cancer (EGC) due to the risk of lymph node metastasis (LNM). However, the distribution pattern of LNM in these patients is complicated and unpredictable. The aim of this study is to identify any different distribution patterns of LNM in patients with EGC who underwent additional surgery after non-curative (ER) comparing to those without ER. METHODS: Patients who underwent surgery for EGC between 2001 and 2016 were included...
October 27, 2018: Journal of Surgical Oncology
Minkyo Song, Charles S Rabkin, M Constanza Camargo
PURPOSE OF REVIEW: Prevalence of Helicobacter pylori, the primary risk factor for gastric cancer, is declining globally. Paralleling this trend, gastric cancer incidence is also decreasing. Historically, the populations most affected by this neoplasia have been males, Asians, and groups with low socioeconomic status. This review provides an update on recently published literature regarding changes in gastric cancer epidemiology. RECENT FINDINGS: Gastric cancer incidence trends vary by age, sex, race/ethnicity, and tumor anatomical location...
October 25, 2018: Current Treatment Options in Gastroenterology
Hanna Yang, Dongwan Hong, Soo Young Cho, Young Soo Park, Woo Ri Ko, Ju Hee Kim, Hoon Hur, Jongkeun Lee, Su-Jin Kim, Sun Young Kwon, Jae-Hyuk Lee, Do Youn Park, Kyu Sang Song, Heekyung Chang, Min-Hee Ryu, Kye Soo Cho, Jeong Won Kang, Myeong-Cherl Kook, Nina Thiessen, An He, Andy Mungall, Sang-Uk Han, Hark Kyun Kim
We conducted an RNA sequencing study to identify novel gene fusions in 80 discovery dataset tumors collected from young patients with diffuse gastric cancer (DGC). Twenty-five in-frame fusions are associated with DGC, three of which (CLDN18-ARHGAP26, CTNND1-ARHGAP26, and ANXA2-MYO9A) are recurrent in 384 DGCs based on RT-PCR. All three fusions contain a RhoGAP domain in their 3' partner genes. Patients with one of these three fusions have a significantly worse prognosis than those without. Ectopic expression of CLDN18-ARHGAP26 promotes the migration and invasion capacities of DGC cells...
October 25, 2018: Nature Communications
Tae Young Kim, Nam Hee Yi, Jin Won Hwang, Ji Hyun Kim, Gwang Ha Kim, Mi Seon Kang
BACKGROUND: The aims of this study are to evaluate the usefulness of submucosal deformity pattern analysis with endoscopic ultrasonography (EUS) for predicting the depth of invasion in early gastric cancer (EGC) and the treatment results of endoscopic submucosal dissection (ESD). METHODS: The endoscopic and EUS parameters of 345 patients with endoscopically suspected EGC who underwent endoscopic or surgical resection between July 2012 and May 2017 were retrospectively reviewed...
October 17, 2018: Surgical Endoscopy
Soo Im Chung, Sang Chul Lee, Seong Joon Yi, Mi Young Kang
BACKGROUND/OBJECTIVES: Oxidative stress is a major cause of cancer. This study investigated the effects of the ethanol extracts from germinated and non-germinated Keunnunjami rice, a blackish-purple pigmented cultivar with giant embryo, on selected human cancer cell lines and on the antioxidant defense system of mice fed with a high-fat diet. MATERIALS/METHODS: High fat-fed mice were orally administered with either distilled water (HF) or extracts (0.25%, w/w) from brown (B), germinated brown (GB), Keunnunjami (K), and germinated Keunnunjami (GK) rice...
October 2018: Nutrition Research and Practice
Hak Jin Kim, Eun Jeong Cho, Mi Hyang Kwak, Bang Wool Eom, Hong Man Yoon, Soo-Jeong Cho, Jong Yeul Lee, Chan Gyoo Kim, Keun Won Ryu, Young-Woo Kim, Il Ju Choi
PURPOSE: We investigated the effect of gastrectomy on blood pressure (BP) in early gastric cancer survivors with hypertension and whether well-controlled BP was due solely to surgery-induced weight loss. METHODS: The study enrolled 66 early gastric cancer patients with hypertension, undergoing endoscopic submucosal dissection (ESD), or gastrectomy. Blood analyses, 24-h ambulatory BP monitoring, brachial ankle pulse wave velocity (baPWV), and echocardiography were measured prior to, 3 months after, and 1 year after ESD or gastrectomy...
October 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Chang Yong Yun, Nayoung Kim, Jaebong Lee, Ju Yup Lee, Young Jae Hwang, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Jin-Wook Kim, Dong Ho Lee
BACKGROUND: The operative link on gastric atrophy (OLGA) and operative link on gastric intestinal metaplasia (OLGIM) stages have been suggested for risk estimation of gastric cancer (GC). However, usefulness of OLGA/OLGIM systems in diffuse type of GC was not investigated so far. The aims of this study were to evaluate the OLGA/OLGIM systems in estimating the GC risk according to Lauren's classification and to investigate the interaction among the risk factors. MATERIALS AND METHODS: The OLGA/OLGIM stages were evaluated in 1398 (765 control and 633 GC patients) who were prospectively enrolled in the Seoul National University Bundang Hospital...
October 10, 2018: Helicobacter
So Hyun Kang, Young Suk Park, Do Joong Park, Hyung-Ho Kim, Sang-Hoon Ahn
No abstract text is available yet for this article.
October 9, 2018: Annals of Surgical Oncology
Yejin Lee, Byungho Lim, Seon Woo Lee, Woo Rin Lee, Yong-In Kim, Minhyeok Kim, Hyoungseok Ju, Mi Young Kim, Suk-Jo Kang, Ji-Joon Song, J Eugene Lee, Changwon Kang
BACKGROUND: Human ANKRD9 (ankyrin repeat domain 9) expression is altered in some cancers. METHODS: We tested genetic association of ANKRD9 with gastric cancer susceptibility and examined functional association of ANKRD9 with altered proliferation of MKN45 gastric cancer cells. We then identified ANKRD9-binding partners in HEK 293 embryonic kidney cells using quantitative proteomics, western blotting and complex reconstitution assays. We finally demonstrated ANKRD9's role of recognizing substrates for ubiquitination using in vitro ubiquitylation assay...
October 2018: Biochimica et biophysica acta. Molecular basis of disease
Jong Won Lee, Jae Sook Sung, Young Soo Park, Seok Chung, Yeul Hong Kim
Isolation of spheroid-forming cells is important to investigate cancer stem cell (CSC) characteristics. However, conventional tumor spheroid culture methods have not proven suitable because the aggregated spheroids generally maintain their original heterogeneity and harbor multiple cells with various characteristics. Here we cultured spheroids using a polydimethylsiloxane microwell-based method and a limiting dilution protocol. We then isolated and enriched for CSCs that formed single cell-derived spheroids from gastric cancer cell lines...
October 2018: BioTechniques
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