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https://www.readbyqxmd.com/read/28915605/hsp90-inhibitor-17-dmag-exerts-anticancer-effects-against-gastric-cancer-cells-principally-by-altering-oxidant-antioxidant-balance
#1
Jeong Goo Kim, Sang Chul Lee, Ok-Hee Kim, Kee-Hwan Kim, Kyo Young Song, Sang Kuon Lee, Byung Jo Choi, Wonjun Jeong, Say-June Kim
Heat shock protein 90 (HSP90) stabilizes numerous oncoproteins and, therefore, its inhibition has emerged as a promising antineoplastic strategy for diverse malignancies. In this study, we determined the therapeutic effects and mechanisms of action of a specific HSP90 inhibitor, 17-dimethylamino-ethylamino-17-demethoxygeldanamycin (17-DMAG), in gastric cancer cell lines (AGS, SNU-1, and KATO-III), patient-derived tissues, and a mouse xenograft model. 17-DMAG exerted anticancer effects against gastric cancer cells, manifested by significantly decreased proliferation rates (P < 0...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28906366/risk-factors-for-lymph-node-metastasis-of-early-gastric-cancers-in-patients-younger-than-40
#2
Tao Ji, Fan Zhou, John Wang, Li Zi
This research aims to explore the potential risk factors of lymph node metastasis (LNM) for early gastric cancers in young patients.We retrospectively collected data from 4287 patients who underwent gastrectomy from January 2005 to December 2015 at Linyi People's Hospital. Of these, we enrolled 397 eligible consecutive patients who had early gastric cancer, then divided them into 2 groups according to age (≤40 years and >40 years). The association between the clinicopathological factors and LNM was analyzed by univariate and multivariate analysis...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28903552/impact-of-body-mass-index-on-the-quality-of-life-after-total-gastrectomy-for-gastric-cancer
#3
Ki Bum Park, Ji Yeon Park, Seung Soo Lee, Oh Kyoung Kwon, Ho Young Chung, Wansik Yu
Purpose: We evaluated the impact of postoperative body mass index (BMI) shifts on the quality of life (QoL) following total gastrectomy in patients with gastric cancer. Methods and Methods: QoL data collected from the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-STO22 questionnaires were obtained from 417 patients preoperatively and 1 year after surgery. Patients were divided into two groups based on changes in BMI: group 1 comprised patients whose BMI range category dropped, and group 2 included patients who maintained or rose to a higher category compared to their preoperative BMI category...
September 13, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28900841/right-side-approach-duet-totally-laparoscopic-distal-gastrectomy-r-duet-tldg-using-a-three-port-to-treat-gastric-cancer
#4
Ho Seok Seo, Kyo Young Song, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
BACKGROUND: Gastric cancer is commonly treated via minimally invasive surgery. The present study explored the feasibility of right-side approach-duet (R-duet) totally laparoscopic distal gastrectomy using a three-port compared with a four- or five-port. METHODS: A total of 251 patients who underwent curative totally laparoscopic distal gastrectomy for gastric cancer (72 R-duet, 74 four-port, and 105 five-port) at the Catholic Medical Center were enrolled. All operations were performed using conventional laparoscopic instruments...
September 12, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28889157/epidemiologic-characteristics-of-gastric-malignancies-among-jordan-university-hospital-patients
#5
Heyam A Awad, Manar H Hajeer, Mohand W Abulihya, Mohammad A Al-Chalabi, Ali A Al Khader
To discover the epidemiologic distribution of gastric malignancies among Jordan University Hospital patients and to compare this distribution with the neighboring Arab countries. Methods: Retrospective study covering the period between  January 2006, and May 2016, in Jordan University Hospital, Amman, Jordan. All cases were retrieved from the computer system and analyzed using IBM SPSS version 23 software.  Results: One hundred and sixty-five cases were analyzed. Male-to-female ratio was 1.2:1. The mean age was 58...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28885374/predictive-factors-to-diagnosis-undifferentiated-early-gastric-cancer-after-endoscopic-submucosal-dissection
#6
Dae G Ryu, Cheol W Choi, Dae H Kang, Hyung W Kim, Su B Park, Su J Kim, Hyeong S Nam
It is difficult to predict precisely whether the lesion corresponds to endoscopic resection indication. Furthermore, discrepancy may occur between endoscopic forceps biopsy (EFB) and finally resected specimen, which may be diagnosed as undifferentiated cancer and additional surgery may be required. Our study aimed to evaluate predictive factors to diagnose undifferentiated cancer after endoscopic submucosal dissection (ESD).Among the 532 patients diagnosed by ESD between January 2009 and December 2015, 557 early gastric cancer (EGC) cases were studied...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28882702/tumoral-foxp3-expression-is-associated-with-favorable-clinicopathological-variables-and-good-prognosis-in-gastric-adenocarcinoma-the-tumor-suppressor-function-of-tumoral-foxp3-is-related-with-the-p21-expression-in-gastric-adenocarcinoma
#7
Kyu Yeoun Won, Gou Young Kim, Hyung Kyung Kim, Sung Il Choi, Sang Hyun Kim, Go Eun Bae, Jun Uk Lim, Sung-Jig Lim
The function and its contribution of tumoral FOXP3 in gastric cancer development remains poorly understood. Thus, we studied the expression of tumoral FOXP3 and its relationship with the well-known tumor suppressor proteins P21 and P53 in gastric adenocarcinoma. The tissue microarray (TMA) was constructed from 182 cases of gastric adenocarcinoma. The immunohistochemistry was performed on 4μm tissue sections from each TMA block. We found that positive tumoral FOXP3 expression was significantly correlated with a lower T category, a lower N category, a lower recurrence rate, and less lymphatic invasion...
September 4, 2017: Human Pathology
https://www.readbyqxmd.com/read/28875981/unraveling-genetic-predisposition-to-familial-or-early-onset-gastric-cancer-using-germline-whole-exome-sequencing
#8
Ingrid P Vogelaar, Rachel S van der Post, J Han Jm van Krieken, Liesbeth Spruijt, Wendy Ag van Zelst-Stams, C Marleen Kets, Jan Lubinski, Anna Jakubowska, Urszula Teodorczyk, Cora M Aalfs, Liselotte P van Hest, Hugo Pinheiro, Carla Oliveira, Shalini N Jhangiani, Donna M Muzny, Richard A Gibbs, James R Lupski, Joep de Ligt, Lisenka E L M Vissers, Alexander Hoischen, Christian Gilissen, Maartje van de Vorst, Jelle J Goeman, Hans K Schackert, Guglielmina N Ranzani, Valeria Molinaro, Encarna B Gómez García, Frederik J Hes, Elke Holinski-Feder, Maurizio Genuardi, Margreet G E M Ausems, Rolf H Sijmons, Anja Wagner, Lizet E van der Kolk, Inga Bjørnevoll, Hildegunn Høberg-Vetti, Ad Geurts van Kessel, Roland P Kuiper, Marjolijn J L Ligtenberg, Nicoline Hoogerbrugge
Recognition of individuals with a genetic predisposition to gastric cancer (GC) enables preventive measures. However, the underlying cause of genetic susceptibility to gastric cancer remains largely unexplained. We performed germline whole-exome sequencing on leukocyte DNA of 54 patients from 53 families with genetically unexplained diffuse-type and intestinal-type GC to identify novel GC-predisposing candidate genes. As young age at diagnosis and familial clustering are hallmarks of genetic tumor susceptibility, we selected patients that were diagnosed below the age of 35, patients from families with two cases of GC at or below age 60 and patients from families with three GC cases at or below age 70...
September 6, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28874038/atrophic-gastritis-increases-the-risk-of-gastric-cancer-in-asymptomatic-population-in-korea
#9
EDITORIAL
Dae Young Cheung
No abstract text is available yet for this article.
September 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28873240/gastric-poorly-cohesive-carcinoma-a-correlative-study-of-mutational-signatures-and-prognostic-significance-based-on-histopathologic-subtypes
#10
Chae Hwa Kwon, Young Keum Kim, Sojeong Lee, Ahrong Kim, Hye Ji Park, Yuri Choi, Yeo Jin Won, Do Youn Park, Gregory Y Lauwers
AIMS: Genome-wide next-generation sequencing has revealed several driver mutations and allows establishing a molecular taxonomy of gastric cancer. However, correlation between the broad mutational spectrum of gastric cancer and its various clinicopathological characteristics has yet to be fully elucidated. METHODS AND RESULTS: Herein, we analyzed the mutational pattern of 77 genes in a cohort of 91 patients with poorly cohesive carcinoma using targeted sequencing and evaluated the clinicopathological significance of the various mutations based its histologic pattern, either signet ring cell (SRC) or other types of poorly cohesive carcinoma (not otherwise specified) (PCC-NOS)...
September 5, 2017: Histopathology
https://www.readbyqxmd.com/read/28843920/tumour-infiltrating-lymphocytes-are-predictors-of-lymph-node-metastasis-in-early-gastric-cancers
#11
Joo Young Kim, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Yang-Seok Chae
Lymph node metastasis (LNM) is an important factor for predicting prognosis and selecting appropriate treatment in early gastric cancers (EGCs). We investigated the histopathological and microenvironmental predictors of LNM in EGCs. We retrieved 43 cases of EGC without LNM and 59 cases with LNM. Clinicopathological variables and tumour-infiltrating lymphocytes (TILs), Crohn's-like lymphoid reaction (CLR), tumour stromal percentage (TSP), and FOXA1 expression were evaluated and correlated with LNM. Among the 102 cases, 68 cases (66...
August 23, 2017: Pathology
https://www.readbyqxmd.com/read/28835091/gastric-adenocarcinoma-with-systemic-metastasis-involving-the-intraocular-choroid-and-duodenum
#12
Soon Young Kim, Kee-Taek Jang, Jun Haeng Lee
Gastric cancer with double metastasis to the orbit and duodenum is extremely rare. We report the case of a patient with gastric adenocarcinoma who presented with synchronous orbital and duodenal metastases at the time of initial diagnosis. A 60-year-old man presented with a 1-month history of visual disorder and pain in his right eye. He underwent ophthalmological examinations. The biopsy results suggested intraocular metastatic carcinoma. We conducted a systemic evaluation to identify primary malignancy. Finally, a diagnosis of advanced gastric adenocarcinoma with multi-organ metastasis was made...
May 22, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28831414/paraneoplastic-atypical-scleromyxedema-with-advanced-gastric-cancer
#13
Se Jin Oh, Seung Hwan Oh, Ji-Young Jun, Ji-Hye Park, Jong Hee Lee, Dong-Youn Lee, Joo-Heung Lee, Jun-Mo Yang
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28828688/nomograms-predicting-survival-of-patients-with-unresectable-or-metastatic-gastric-cancer-who-receive-combination-cytotoxic-chemotherapy-as-first-line-treatment
#14
Sun Young Kim, Min Joo Yoon, Young Iee Park, Mi Jung Kim, Byung-Ho Nam, Sook Ryun Park
BACKGROUND: Some clinicopathological variables are known to influence the survival of patients with advanced gastric cancer. A comprehensive model based on these factors is needed for prediction of an individual's survival and appropriate patient counseling. METHODS: A nomogram for predicting 1-year survival in patients with advanced gastric cancer in the palliative chemotherapy setting was developed using clinicopathological data from 949 patients with unresectable or metastatic gastric cancer who had received first-line doublet cytotoxic chemotherapy from 2001 to 2006 at the National Cancer Center, Korea (Baseline Nomogram)...
August 21, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28801429/multicentric-randomised-study-of-helicobacter-pylori-eradication-and-pepsinogen-testing-for-prevention-of-gastric-cancer-mortality-the-gistar-study
#15
Marcis Leja, Jin Young Park, Raul Murillo, Inta Liepniece-Karele, Sergejs Isajevs, Ilze Kikuste, Dace Rudzite, Petra Krike, Sergei Parshutin, Inese Polaka, Arnis Kirsners, Daiga Santare, Valdis Folkmanis, Ilva Daugule, Martyn Plummer, Rolando Herrero
INTRODUCTION: Population-based eradication of Helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. However, the potential adverse effects of widespread antibiotic use that this would entail have not been sufficiently studied. An alternative way to decrease gastric cancer mortality is by non-invasive search for precancerous lesions, in particular gastric atrophy; pepsinogen tests are the best currently available alternative. The primary objective of GISTAR is to determine whether H pylori eradication combined with pepsinogen testing reduces mortality from gastric cancer among 40-64-year-old individuals...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28798286/the-characteristics-and-prognosis-of-diffuse-type-early-gastric-cancer-diagnosed-during-health-check-ups
#16
Ji Young Lee, Eun Jeong Gong, Eun Ju Chung, Hye Won Park, Suh Eun Bae, Eun Hee Kim, Jaeil Kim, Yoon Suh Do, Tae Hyup Kim, Hye-Sook Chang, Ho June Song, Jaewon Choe, Hwoon-Yong Jung
Background/Aims: Because of the poor prognosis of diffuse-type gastric cancer, early detection is important. We investigated the clinical characteristics and prognosis of diffuse-type early gastric cancer (EGC) diagnosed in subjects during health check-ups. Methods: Among 121,111 subjects who underwent gastroscopy during a routine health check-up, we identified 282 patients with 286 EGC lesions and reviewed their clinical and tumor-specific parameters. Results: Patients with diffuse-type EGC were younger, and 48...
August 14, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28768236/programmed-death-ligand-1-and-met-co-expression-is-a-poor-prognostic-factor-in-gastric-cancers-after-resection
#17
Mi Jung Kwon, Kab-Choong Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Hye Kyung Lee, Ho Suk Kang, Kyueng-Whan Min
Programmed death-ligand 1 (PD-L1) plays an essential protein for immune evasion, contributing to tumor development and progression. Recent studies have reported MET as an upregulator for PD-L1 overexpression through an oncogenic pathway. However, an association between PD-L1 expression with MET has not been reported in gastric cancer.The prognostic significance of PD-L1 and its association with Epstein-Barr virus (EBV), microsatellite instability (MSI), and mucin phenotype remain controversial.We performed in situ hybridization for EBV-encoded RNA and immunohistochemistry in tissue microarrays for 394 gastric cancers...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747339/clinical-significance-of-four-molecular-subtypes-of-gastric-cancer-identified-by-the-cancer-genome-atlas-project
#18
Bo Hwa Sohn, Jun-Eul Hwang, Hee-Jin Jang, Hyun-Sung Lee, Sang Cheul Oh, Jae-Jun Shim, Keun-Wook Lee, Eui Hyun Kim, Sun Young Yim, Sang Ho Lee, Jae-Ho Cheong, Woojin Jeong, Jae Yong Cho, Joohee Kim, Jungsoo Chae, Jeeyun Lee, Won Ki Kang, Sung Kim, Sung Hoon Noh, Jaffer A Ajani, Ju-Seog Lee
Purpose: The Cancer Genome Atlas (TCGA) project recently uncovered four molecular subtypes of gastric cancer: Epstein-Barr virus (EBV), microsatellite instability (MSI), genomically stable (GS), and chromosomal instability (CIN). However, their clinical significances are currently unknown. We aimed to investigate the relationship between subtypes and prognosis of patients with gastric cancer.Experimental Design: Gene expression data from a TCGA cohort (n = 262) were used to develop a subtype prediction model, and the association of each subtype with survival and benefit from adjuvant chemotherapy was tested in 2 other cohorts (n = 267 and 432)...
July 26, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28746176/comparison-of-clinical-outcomes-after-endoscopic-submucosal-dissection-and-surgery-in-the-treatment-of-early-gastric-cancer-a-single-institute-study
#19
COMPARATIVE STUDY
Ji Young Chang, Ki-Nam Shim, Chung Hyun Tae, Ko Eun Lee, Jihyun Lee, Kang Hoon Lee, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung, Sung-Ae Jung, Joo-Ho Lee, Min-Sun Cho
The feasibility of expanding the indications for endoscopic submucosal dissection to treat early gastric cancer based on long-term outcomes has shown conflicting results. This study aimed to investigate whether outcomes or adverse events associated with endoscopic submucosal dissection are comparable to those of surgery for early gastric cancer that including the absolute and expanded indications.Data of 159 early gastric cancers from 153 patients treated with endoscopic submucosal dissection or surgery between January 2004 and October 2014 were reviewed retrospectively...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28743132/therapeutic-outcomes-of-endoscopic-resection-of-early-gastric-cancer-with-undifferentiated-type-histology-a-korean-esd-registry-database-analysis
#20
Chang Seok Bang, Jae Myung Park, Gwang Ho Baik, Jong Jae Park, Moon Kyung Joo, Jae Young Jang, Seong Woo Jeon, Suck Chei Choi, Jae Kyu Sung, Kwang Bum Cho
Background/Aims: To assess the therapeutic outcomes of endoscopic resection (ER) of early gastric cancer (EGC) with undifferentiated-type histology. Methods: Cases of ER of EGC with undifferentiated-type histology in the Korean endoscopic submucosal dissection (ESD) registry database were identified and reviewed. The immediate outcomes, including en bloc resection, complete resection, and curative resection rates, and long-term outcomes, including recurrence and survival rates, were extracted and analyzed...
July 25, 2017: Clinical Endoscopy
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