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Young gastric cancer

Do Joong Park, Young Suk Park, Sang Yong Son, Ju-Hee Lee, Hye Seung Lee, Young Soo Park, Kyoung Ho Lee, Young Hoon Kim, Kyoung Un Park, Won Woo Lee, Soyeon Ahn, Sang-Hoon Ahn, Hyung-Ho Kim
BACKGROUND: Sentinel node navigation surgery (SNNS) in early gastric cancer (EGC) is technically feasible according to previous literature, however its long-term oncologic safety has not been reported. METHODS: A single-center, single-arm, phase II trial was conducted to determine the oncologic outcomes of laparoscopic sentinel node (SN) biopsy in clinical stage T1N0M0 gastric cancer patients. Cases with positive SNs on intraoperative pathologic examination underwent conventional gastrectomy with radical lymphadenectomy (SN-positive group), whereas those with negative SNs underwent laparoendoscopic-limited gastric resections without further lymph node dissections (SN-negative group)...
May 21, 2018: Annals of Surgical Oncology
Young Suk Park, Do Joong Park, Yoontaek Lee, Ki Bum Park, Sa-Hong Min, Sang-Hoon Ahn, Hyung-Ho Kim
BACKGROUND: Most gastric cancer (GC) patients rapidly lose weight after gastrectomy. Therefore, analysis of the effect of body mass index (BMI) on GC patients survival should include postoperative BMI and BMI loss as well as preoperative BMI. This retrospective cohort study analyzed the effect of three BMI variables and their interaction on long-term outcomes. METHODS: Preoperative BMI analysis included 2063 GC patients who underwent curative gastrectomy between January, 2009 and December, 2013 at Seoul National University Bundang Hospital...
May 21, 2018: Cancer Epidemiology, Biomarkers & Prevention
Yoon Jin Choi, Dong Ho Lee, Kyung-Do Han, Hyun Soo Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim
[This corrects the article DOI: 10.1371/journal.pone.0185778.].
2018: PloS One
Jooyoung Lee, Hyosil Kim, Jae Eun Lee, Su-Jin Shin, Sejin Oh, Sungjin Kwon, Hakhyun Kim, Yoon Young Choi, Michael A White, Soonmyung Paik, Jae-Ho Cheong, Hyun Seok Kim
BACKGROUND & AIMS: Markers of the epithelial-mesenchymal transition (EMT) in gastric tumor tissues are associated with poor outcomes of patients. We performed a screen to identify pharmacologic compounds that kill gastric cancer cells with EMT-associated gene expression patterns and investigate their mechanisms. METHODS: We identified 29 gastric cancer cell lines with gene expression signature previously associated with an EMT subtype, based on data from RNA sequence analyses, and confirmed their mesenchymal phenotypes of 7 lines (Hs746T, SNU1750, MKN1, SK4, SNU484, SNU668, and YCC11), based in invasive activity and protein markers...
May 15, 2018: Gastroenterology
Xinfu Ma, Dengfeng Ren, Jie Kan, Fangchao Zheng, Shuisheng Zhang, Yu Zhang, Yuying Li, Zhibo Liu, Linhan Ye, Guoshuang Shen, Ziyi Wang, Fuxing Zhao, Raees Ahmad, Jiuda Zhao
The number of elderly gastric cancer (GC) patients has been rapidly increasing worldwide, but inadequate understanding regarding elderly GC patients has led to the paucity of appropriate treatment decisions. Our study evaluates clinicopathological characteristics and prognoses of elderly GC patients after R0 resection. Overall, 1877 consecutive GC patients who underwent R0 gastrectomy at four centers were enrolled. We divided patients into three groups according to age: young, middle, and elderly. We then analyzed clinicopathological characteristics and prognoses...
2018: Journal of Environmental Pathology, Toxicology and Oncology
Myoung-Hee Kang, Hyunji Choi, Masanobu Oshima, Jae-Ho Cheong, Seokho Kim, Jung Hoon Lee, Young Soo Park, Hueng-Sik Choi, Mi-Na Kweon, Chan-Gi Pack, Ju-Seog Lee, Gordon B Mills, Seung-Jae Myung, Yun-Yong Park
The principle factors underlying gastric cancer (GC) development and outcomes are not well characterized resulting in a paucity of validated therapeutic targets. To identify potential molecular targets, we analyze gene expression data from GC patients and identify the nuclear receptor ESRRG as a candidate tumor suppressor. ESRRG expression is decreased in GC and is a predictor of a poor clinical outcome. Importantly, ESRRG suppresses GC cell growth and tumorigenesis. Gene expression profiling suggests that ESRRG antagonizes Wnt signaling via the suppression of TCF4/LEF1 binding to the CCND1 promoter...
May 15, 2018: Nature Communications
Gemma Bruera, Silvia Massacese, Antonio Galvano, Antonella Dal Mas, Stefano Guadagni, Giuseppe Calvisi, Eugenio Ciacco, Antonio Russo, Enrico Ricevuto
Introduction: Proper administration timing, dose-intensity, efficacy/toxicity ratio of triplet docetaxel (DTX), 5-fluorouracil (5-FU), and oxaliplatin (OXP) should be improved to safely perform three-drugs intensive first line in advanced gastric cancer (GC). This dose-finding study investigated recommended 5-FU and OXP doses, safety of triplet regimen and preliminary activity. Methods: Schedule: 12h-timed-flat-infusion 5-FU 700-1000 mg/m2 /d 1-2, 8-9, 15-16, 22-23, with 100 mg/m2 /d increase for dose level; DTX 50 mg/m2 d 1, 15 fixed dose, OXP at three increasing dose-levels 60-70-80 mg/m2 d 8, 22, every 4 weeks...
April 17, 2018: Oncotarget
Zhengyun Zou, Lianjun Zhao, Shu Su, Qin Liu, Lixia Yu, Jia Wei, Yang Yang, Juan Du, Jie Shen, Xiaoping Qian, Xiangshan Fan, Wenxian Guan, Baorui Liu
To assess the association of plasma cytokines and growth factor levels with clinical characteristics and inflammatory indices in patients with gastric cancer.Plasma samples derived from 99 gastric cancer patients were used for analysis. Levels of interferon (IFN)-γ, tumor growth factor (TGF)-β1, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-12p70, and vascular endothelial growth factor (VEGF) were measured by Luminex suspension array technology. The association between cytokine/growth factor levels and demographic/clinical characteristics was assessed...
May 2018: Medicine (Baltimore)
Yoon Young Choi, Hyunki Kim, Su-Jin Shin, Ha Yan Kim, Jinae Lee, Han-Kwang Yang, Woo Ho Kim, Young-Woo Kim, Myeong-Cherl Kook, Young Kyu Park, Hyung-Ho Kim, Hye Seung Lee, Kyung Hee Lee, Mi Jin Gu, Seung Ho Choi, SoonWon Hong, Jong Won Kim, Woo Jin Hyung, Sung Hoon Noh, Jae-Ho Cheong
OBJECTIVE: We investigated microsatellite instability (MSI) status and programed cell death ligand 1 (PD-L1) expression as predictors of prognosis and responsiveness to chemotherapy for stage II/III gastric cancer. BACKGROUND: The clinical implications of MSI status and PD-L1 expression in gastric cancer have not been well-elucidated. METHODS: Tumor specimens and clinical information were collected from patients enrolled in the CLASSIC trial-a randomized controlled study of capecitabine plus oxaliplatin-based adjuvant chemotherapy...
May 1, 2018: Annals of Surgery
Sang Cheul Oh, Bo Hwa Sohn, Jae-Ho Cheong, Sang-Bae Kim, Jae Eun Lee, Ki Cheong Park, Sang Ho Lee, Jong-Lyul Park, Yun-Yong Park, Hyun-Sung Lee, Hee-Jin Jang, Eun Sung Park, Sang-Cheol Kim, Jeonghoon Heo, In-Sun Chu, You-Jin Jang, Young-Jae Mok, WonKyung Jung, Baek-Hui Kim, Aeree Kim, Jae Yong Cho, Jae Yun Lim, Yuki Hayashi, Shumei Song, Elena Elimova, Jeannelyn S Estralla, Jeffrey H Lee, Manoop S Bhutani, Yiling Lu, Wenbin Liu, Jeeyun Lee, Won Ki Kang, Sung Kim, Sung Hoon Noh, Gordon B Mills, Seon-Young Kim, Jaffer A Ajani, Ju-Seog Lee
Gastric cancer is a heterogeneous cancer, making treatment responses difficult to predict. Here we show that we identify two distinct molecular subtypes, mesenchymal phenotype (MP) and epithelial phenotype (EP), by analyzing genomic and proteomic data. Molecularly, MP subtype tumors show high genomic integrity characterized by low mutation rates and microsatellite stability, whereas EP subtype tumors show low genomic integrity. Clinically, the MP subtype is associated with markedly poor survival and resistance to standard chemotherapy, whereas the EP subtype is associated with better survival rates and sensitivity to chemotherapy...
May 3, 2018: Nature Communications
Hyunho Kim, Sang Mi Ro, Ji Hyun Yang, Joon Won Jeong, Ji Eun Lee, Sang Young Roh, In-Ho Kim
Background/Aims: Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC). Methods: We retrospectively reviewed the records of 502 patients who received first-line palliative chemotherapy for mGC between 2007 and 2013. The neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognostic score (mGPS) were assessed before and after chemotherapy to evaluate their association with survival...
May 4, 2018: Korean Journal of Internal Medicine
Ho Seok Seo, Kyo Young Song, Yoon Ju Jung, Seung Man Park, Hae Myung Jeon, Wook Kim, Hyung Min Chin, Jin-Jo Kim, Sung Keun Kim, Kyung Hwa Chun, Jeong Goo Kim, Jun Hyun Lee, Han Hong Lee, Dong Jin Kim, Han Mo Yoo, Chang Hyun Kim, Eun Young Kim, Cho Hyun Park
ABASTRACT: BACKGROUND: Despite the development of newer treatments, the prognosis for patients with stage IV gastric cancer remains grave. This study evaluated the efficacy of gastrectomy following response to chemotherapy in patients with stage IV gastric cancer. METHODS: A total of 419 patients who were diagnosed with stage IV gastric cancer were identified from the multi-institutional Catholic Gastric Cancer Study Group database. The patients were divided into four groups: 212 were in the chemotherapy only (CTx) group, 124 were in the chemotherapy after palliative gastrectomy (G-CTx) group, 23 were in the radical gastrectomy after chemotherapy (CTx-G) group, and 60 were in the best supportive care group...
May 1, 2018: World Journal of Surgery
Gi Yong Hwang, Dong Won Baek, Hee Jeong Cho, Soo Jung Lee, Yee Soo Chae, Byung Woog Kang, In Hee Lee, Jong Gwang Kim, An Na Seo, Han Ik Bae, Ki Bum Park, Ji Yeon Park, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung
BACKGROUND/AIM: This study investigated the clinical prognostic relevance of the neutrophil-to-lymphocyte ratio (NLR) in patients with human epidermal receptor 2 (HER2)-positive metastatic advanced gastric cancer (AGC) treated with combination chemotherapy including trastuzumab. PATIENTS AND METHODS: This is a retrospective analysis of 73 patients diagnosed with metastatic AGC who were treated with trastuzumab combination chemotherapy. NLR was calculated as the neutrophil count divided by the lymphocyte count...
May 2018: Anticancer Research
Jung Hwan Yoon, In-Hye Ham, Olga Kim, Hassan Ashktorab, Duane T Smoot, Suk Woo Nam, Jung Young Lee, Hoon Hur, Won Sang Park
BACKGROUND: Gastrokine 1 (GKN1) plays important roles in maintaining mucosal homeostasis, and in regulating cell proliferation and differentiation. Here, we determined whether GKN1 is a potential theragnostic marker for gastric cancer. METHODS: We identified GKN1 binding proteins using the protein microarray assay and investigated whether GKN1 is one of the exosomal cargo proteins by western blot, immunoprecipitation, and immunofluorescent assays. Cell proliferation and apoptosis were analyzed by MTT, BrdU incorporation, flow cytometry, and western blot assays...
April 27, 2018: Gastric Cancer
Keun-Wook Lee, Dae Young Zang, Min-Hee Ryu, Ki Hyang Kim, Mi-Jung Kim, Hye Sook Han, Sung Ae Koh, Jin Hyun Park, Jin Won Kim, Byung-Ho Nam, In Sil Choi
Introduction: The combination of a fluoropyrimidine [5-fluorouracil (5-FU), capecitabine, or S-1] with a platinum analog (cisplatin or oxaliplatin) is the most widely accepted first-line chemotherapy regimen for metastatic or recurrent advanced gastric cancer (AGC), based on the results of clinical trials. However, there is little evidence to guide chemotherapy for elderly patients with AGC because of under-representation of this age group in clinical trials. Thus, the aim of this study is to determine the optimal chemotherapy regimen for elderly patients with AGC by comparing the efficacies and safeties of combination therapy versus monotherapy as first-line chemotherapy...
December 2017: Contemporary Clinical Trials Communications
Brian De, Ryan Rhome, Vikram Jairam, Umut Özbek, Randall F Holcombe, Michael Buckstein, Celina Ang
BACKGROUND: Evidence regarding gastric cancer patients < 40 years old is limited. This study examines young adults with gastric adenocarcinoma in the National Cancer Database to describe demographics and treatment practices, and to develop a nomogram to predict survival. METHODS: The database was queried for adult patients diagnosed with gastric adenocarcinoma from 2004 to 2013. Patients were stratified into two age groups: <40 and ≥ 40 years. The database was analyzed to compare demographics, clinical characteristics, and treatments used for each group...
April 24, 2018: Gastric Cancer
Jieyun Zhang, Lu Gan, Mi-Die Xu, Mingzhu Huang, Xiaowei Zhang, Yiwei Gong, Xi Wang, Guanzhen Yu, Weijian Guo
Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respectively. 50-year-old was treated as cutoff age. Propensity score method was used to carry out a 1:1 paired match. Results: In the U.S. cohort, we found that younger patients presented poor tumor behavior...
2018: Journal of Cancer
Jin Young Park, David Forman, Langgeng Agung Waskito, Yoshio Yamaoka, Jean E Crabtree
Gastric cancer is a major health burden and is the fifth most common malignancy and the third most common cause of death from cancer worldwide. Development of gastric cancer involves several aspects, including host genetics, environmental factors, and Helicobacter pylori infection. There is increasing evidence from epidemiological studies of the association of H. pylori infection and specific virulence factors with gastric cancer. Studies in animal models indicate H. pylori is a primary factor in the development of gastric cancer...
April 19, 2018: Toxins
Wonyoung Choi, Jeongsik Kim, Jaeoh Park, Da-Hye Lee, Daehee Hwang, Jeong-Hwan Kim, Hassan Ashktorab, Duane T Smoot, Seon-Young Kim, Chan Choi, Gou Young Koh, Dae-Sik Lim
YAP and TAZ play oncogenic roles in various organs, but the role of YAP/TAZ in gastric cancer remains unclear. Here we show that YAP/TAZ activation initiates gastric tumorigenesis in vivo and verify its significance in human gastric cancer. In mice, YAP/TAZ activation in the pyloric stem cell led to step-wise tumorigenesis. RNA sequencing identified MYC as a decisive target of YAP, which controls MYC at transcriptional and post-transcriptional levels. These mechanisms tightly regulated MYC in homeostatic conditions, but YAP activation altered this balance by impeding miRNA processing, causing a shift towards MYC upregulation...
April 18, 2018: Cancer Research
Jung Hwan Lee, Boram Park, Jungnam Joo, Myeong-Cherl Kook, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Bang Wool Eom, Hong Man Yoon, Keun Won Ryu, Young-Woo Kim, Soo-Jeong Cho
BACKGROUND: The effects of obesity on prognosis in gastric cancer are controversial. AIMS: To evaluate the association between body mass index (BMI) and mortality in patients with gastric cancer. METHODS: A single-institution cohort of 7765 patients with gastric cancer undergoing curative gastrectomy between October 2000 and June 2016 was categorized into six groups based on BMI: underweight (< 18.5 kg/m2 ), normal (18.5 to < 23 kg/m2 ), overweight (23 to < 25 kg/m2 ), mildly obese (25 to < 28 kg/m2 ), moderately obese (28 to < 30 kg/m2 ), and severely obese (≥ 30 kg/m2 )...
April 12, 2018: Gastric Cancer
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