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https://www.readbyqxmd.com/read/29324411/virtual-activities-of-daily-living-for-recovery-of-upper-extremity-motor-function
#1
Richard J Adams, Matthew D Lichter, Allison Ellington, Marga White, Kate Armstead, James T Patrie, Paul T Diamond
A study was conducted to investigate the effectiveness of virtual activities of daily living (ADL) practice using the SaeboVR software system for the recovery of upper extremity (UE) motor function following stroke. The system employs Kinect sensor-based tracking to translate human UE motion into the anatomical pose of the arm of the patient's avatar within a virtual environment, creating a virtual presence within a simulated task space. Patients gain mastery of 12 different integrated activities while traversing a metaphorical "road to recovery" that includes thematically linked levels and therapist-selected difficulty settings...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29305386/the-chromatin-remodeler-isw1-prevents-cag-repeat-expansions-during-transcription-in-saccharomyces-cerevisiae
#2
Melissa R Koch, Nealia C M House, Casey M Cosetta, Robyn M Jong, Christelle G Salomon, Cailin E Joyce, Elliot A Philips, Xiaofeng A Su, Catherine H Freudenreich
CAG/CTG trinucleotide repeats are unstable sequences that are difficult to replicate, repair, and transcribe due to their structure-forming nature. CAG repeats strongly position nucleosomes, however little is known about the chromatin remodeling needed to prevent repeat instability. In a Saccharomyces cerevisiae model system with CAG repeats carried on a yeast artificial chromosome, we discovered that the chromatin remodeler Isw1 is required to prevent CAG repeat expansions during transcription. CAG repeat expansions in the absence of Isw1 were dependent on both transcription-coupled repair (TCR) and base excision repair (BER)...
January 5, 2018: Genetics
https://www.readbyqxmd.com/read/29289491/the-effect-of-repetitive-baseball-pitching-on-medial-elbow-joint-space-gapping-associated-with-2-elbow-valgus-stressors-in-high-school-baseball-players
#3
Hiroshi Hattori, Kiyokazu Akasaka, Takahiro Otsudo, Toby Hall, Katsuya Amemiya, Yoshihisa Mori
BACKGROUND: To prevent elbow injury in baseball players, various methods have been used to measure medial elbow joint stability with valgus stress. However, no studies have investigated higher levels of elbow valgus stress. This study investigated medial elbow joint space gapping measured ultrasonically resulting from a 30 N valgus stress vs. gravitational valgus stress after a repetitive throwing task. METHODS: The study included 25 high school baseball players...
December 27, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29286379/automated-robotic-liquid-handling-assembly-of-modular-dna-devices
#4
Luis Ortiz, Marilene Pavan, Lloyd McCarthy, Joshua Timmons, Douglas M Densmore
Recent advances in modular DNA assembly techniques have enabled synthetic biologists to test significantly more of the available "design space" represented by "devices" created as combinations of individual genetic components. However, manual assembly of such large numbers of devices is time-intensive, error-prone, and costly. The increasing sophistication and scale of synthetic biology research necessitates an efficient, reproducible way to accommodate large-scale, complex, and high throughput device construction...
December 1, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29283607/retuning-of-lexical-semantic-representations-repetition-and-spacing-effects-in-word-meaning-priming
#5
Hannah N Betts, Rebecca A Gilbert, Zhenguang G Cai, Zainab B Okedara, Jennifer M Rodd
Current models of word-meaning access typically assume that lexical-semantic representations of ambiguous words (e.g., 'bark of the dog/tree') reach a relatively stable state in adulthood, with only the relative frequencies of meanings and immediate sentence context determining meaning preference. However, recent experience also affects interpretation: recently encountered word-meanings become more readily available (Rodd et al., 2016, 2013). Here, 3 experiments investigated how multiple encounters with word-meanings influence the subsequent interpretation of these ambiguous words...
December 28, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/29250812/a-multiple-model-generalisation-of-updating-clinical-prediction-models
#6
Glen P Martin, Mamas A Mamas, Niels Peek, Iain Buchan, Matthew Sperrin
There is growing interest in developing clinical prediction models (CPMs) to aid local healthcare decision-making. Frequently, these CPMs are developed in isolation across different populations, with repetitive de novo derivation a common modelling strategy. However, this fails to utilise all available information and does not respond to changes in health processes through time and space. Alternatively, model updating techniques have previously been proposed that adjust an existing CPM to suit the new population, but these techniques are restricted to a single model...
December 18, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29245850/design-methodology-for-moir%C3%A3-magnifier-based-on-micro-focusing-elements
#7
Weiwei Zheng, Su Shen, Yulong Gao, Nan Liu, Yanhua Liu
Moiré effect is a well-known interference phenomenon occurred between repetitive structures. Conventional moiré fringes are produced by superposing gratings or dots arrays. However, when the micro-image array as base layer and the corresponding micro-focusing elements as revealing layer overlap each other, a special kind of moiré effect, so-called moiré magnifier, can be observed. Micro-image units in the base layer are enlarged and projected to moiré space. To our knowledge, there has no complete design methodology for the realization of the moiré magnifier...
December 11, 2017: Optics Express
https://www.readbyqxmd.com/read/29241511/increasing-patient-recall-of-nurse-leader-rounding
#8
Sally W Gillam, Andrew R Gillam, Tricia L Casler, Katie Cook
Nursing staff in a medical/surgical acute care 34-bed hospital unit were challenged by low percentages of patients able to recall nurse leader rounding activity (NLR). NLR occurred daily for all patients, yet many did not recall visits by nursing leaders when surveyed at discharge. Care giver credibility suffered as non-nursing executives questioned if NLR consistently occurred. Several mechanisms were used to facilitate patient NLR recall: scripted NLR verbiage/keywords, nursing uniform leadership insignia and white lab coats, sharing of business cards, handwritten notes on patient communication white boards, multimedia leadership insignia on leader e-tablets, and visits with family members: patient NLR recall did not improve...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29226769/working-memory-capacity-and-the-spacing-effect-in-cued-recall
#9
Peter F Delaney, Namrata R Godbole, Latasha R Holden, Yoojin Chang
Spacing repetitions typically improves memory (the spacing effect). In three cued recall experiments, we explored the relationship between working memory capacity and the spacing effect. People with higher working memory capacity are more accurate on memory tasks that require retrieval relative to people with lower working memory capacity. The experiments used different retention intervals and lags between repetitions, but were otherwise similar. Working memory capacity and spacing of repetitions both improved memory in most of conditions, but they did not interact, suggesting additive effects...
December 11, 2017: Memory
https://www.readbyqxmd.com/read/29205604/the-role-of-water-in-plant-microbe-interactions
#10
Kyaw Aung, Yanjuan Jiang, Sheng Yang He
Plants are associated with various microorganisms throughout their life, including commensal, symbiotic and pathogenic microorganisms. Pathogens are genetically adapted to aggressively colonize and proliferate in host plants to cause disease. However, disease outbreaks occur only under permissive environmental conditions. The interplay between host, pathogen and environment is famously known as the "disease triangle". Among the environmental factors, rainfall events, which often create a period of high atmospheric humidity, have repetitively been shown to promote disease outbreaks in plants, suggesting that water availability is crucial for pathogenesis...
December 5, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29176038/the-effect-of-age-on-balancing-behavior-complexity-analysis-of-mediolateral-force-trajectories
#11
Allison Leich Hilbun, Istvan Karsai
We quantified, via complexity analysis, the postural stability of healthy people from a wide age range. Thirty-five healthy people aged 18-72 performed three tasks while balancing on one foot on a force plate: standard balancing task, mental task (balancing while answering basic arithmetic questions), and knot-tying task (balancing while tying two knots in a piece of ribbon). Mediolateral force trajectories were analyzed to determine control strategy via Hurst exponents, Lyapunov exponents, Root Mean Square, and Kolmogorov complexity, and phase-space plots...
November 26, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29162331/the-effect-of-load-on-achilles-tendon-structure-in-novice-runners
#12
Omar W Heyward, Lucas M Rabello, Lucas van der Woude, Inge van den Akker-Scheek, Alli Gokeler, Henk van der Worp, Johannes Zwerver
OBJECTIVES: To observe the changes in Achilles tendon structure in novice runners, with loading prescriptions of 100% body weight compared to 20% body weight. DESIGN: Randomised crossover. METHODS: Twenty novice runners participated in two separate running bouts spaced 14days apart, one of high load at 100% body weight, and one of low load at 20% body weight. Tendon structure was measured by ultrasonographic tissue characterisation on 6 occasions; immediately prior to each run, 2 and 7days after each run...
November 18, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29161293/high-intensity-focused-ultrasound-ablation-around-the-tubing
#13
Jun Yang Siu, Chenhui Liu, Yufeng Zhou
High-intensity focused ultrasound (HIFU) has been emerging as an effective and noninvasive modality in cancer treatment with very promising clinical results. However, a small vessel in the focal region could be ruptured, which is an important concern for the safety of HIFU ablation. In this study, lesion formation in the polyacrylamide gel phantom embedded with different tubing (inner diameters of 0.76 mm and 3 mm) at varied flow speeds (17-339 cm/s) by HIFU ablation was photographically recorded. Produced lesions have decreased length (~30%) but slightly increased width (~6%) in comparison to that without the embedded tubing...
2017: PloS One
https://www.readbyqxmd.com/read/29137497/optimization-of-t2-weighted-imaging-for-shoulder-magnetic-resonance-arthrography-by-synthetic-magnetic-resonance-imaging
#14
Seung Hyun Lee, Young Han Lee, Seok Hahn, Jaemoon Yang, Ho-Taek Song, Jin-Suck Suh
Background Synthetic magnetic resonance imaging (MRI) allows reformatting of various synthetic images by adjustment of scanning parameters such as repetition time (TR) and echo time (TE). Optimized MR images can be reformatted from T1, T2, and proton density (PD) values to achieve maximum tissue contrast between joint fluid and adjacent soft tissue. Purpose To demonstrate the method for optimization of TR and TE by synthetic MRI and to validate the optimized images by comparison with conventional shoulder MR arthrography (MRA) images...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29131193/frequency-and-timing-stability-of-an-airborne-injection-seeded-nd-yag-laser-system-for-direct-detection-wind-lidar
#15
Christian Lemmerz, Oliver Lux, Oliver Reitebuch, Benjamin Witschas, Christian Wührer
We report on the design and performance of the laser deployed in the airborne demonstrator Doppler wind lidar for the Aeolus mission of the European Space Agency (ESA). The all-solid-state, diode-pumped and frequency-tripled Nd:YAG laser is realized as a master oscillator power amplifier (MOPA) system, generating 60 mJ of single-frequency pulses at 355 nm wavelength, 50 Hz repetition rate and 20 ns pulse duration. For the measurement of the Doppler frequency shift over several accumulated laser shots, the frequency stability of the laser is of crucial importance...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29101792/theory-and-particle-tracking-simulations-of-a-resonant-radiofrequency-deflection-cavity-in-tm110-mode-for-ultrafast-electron-microscopy
#16
J F M van Rens, W Verhoeven, J G H Franssen, A C Lassise, X F D Stragier, E R Kieft, P H A Mutsaers, O J Luiten
We present a theoretical description of resonant radiofrequency (RF) deflecting cavities in TM110 mode as dynamic optical elements for ultrafast electron microscopy. We first derive the optical transfer matrix of an ideal pillbox cavity and use a Courant-Snyder formalism to calculate the 6D phase space propagation of a Gaussian electron distribution through the cavity. We derive closed, analytic expressions for the increase in transverse emittance and energy spread of the electron distribution. We demonstrate that for the special case of a beam focused in the center of the cavity, the low emittance and low energy spread of a high quality beam can be maintained, which allows high-repetition rate, ultrafast electron microscopy with 100 fs temporal resolution combined with the atomic resolution of a high-end TEM...
October 12, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/29079778/exercise-dependent-formation-of-new-junctions-that-promote-stim1-orai1-assembly-in-skeletal-muscle
#17
Simona Boncompagni, Antonio Michelucci, Laura Pietrangelo, Robert T Dirksen, Feliciano Protasi
Store-operated Ca(2+) entry (SOCE), a ubiquitous mechanism that allows recovery of Ca(2+) ions from the extracellular space, has been proposed to limit fatigue during repetitive skeletal muscle activity. However, the subcellular location for SOCE in muscle fibers has not been unequivocally identified. Here we show that exercise drives a significant remodeling of the sarcotubular system to form previously unidentified junctions between the sarcoplasmic reticulum (SR) and transverse-tubules (TTs). We also demonstrate that these new SR-TT junctions contain the molecular machinery that mediate SOCE: stromal interaction molecule-1 (STIM1), which functions as the SR Ca(2+) sensor, and Orai1, the Ca(2+)-permeable channel in the TT...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29067730/simultaneous-qsm-and-metabolic-imaging-of-the-brain-using-spice
#18
Xi Peng, Fan Lam, Yudu Li, Bryan Clifford, Zhi-Pei Liang
PURPOSE: To map brain metabolites and tissue magnetic susceptibility simultaneously using a single three-dimensional (1) H-MRSI acquisition without water suppression. METHODS: The proposed technique builds on a subspace imaging method called spectroscopic imaging by exploiting spatiospectral correlation (SPICE), which enables ultrashort echo time (TE)/short pulse repetition time (TR) acquisitions for (1) H-MRSI without water suppression. This data acquisition scheme simultaneously captures both the spectral information of brain metabolites and the phase information of the water signals that is directly related to tissue magnetic susceptibility variations...
October 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29062290/parental-and-infant-gender-factors-in-parent-infant-interaction-state-space-dynamic-analysis
#19
M Angeles Cerezo, Purificación Sierra-García, Gemma Pons-Salvador, Rosa M Trenado
This study aimed to investigate the influence of parental gender on their interaction with their infants, considering, as well, the role of the infant's gender. The State Space Grid (SSG) method, a graphical tool based on the non-linear dynamic system (NDS) approach was used to analyze the interaction, in Free-Play setting, of 52 infants, aged 6 to 10 months, divided into two groups: half of the infants interacted with their fathers and half with their mothers. There were 50% boys in each group. MANOVA results showed no differential parenting of boys and girls...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29048314/the-effectiveness-of-a-learning-strategies-program-for-university-students
#20
Cristina Roces Montero, Beatriz Sierra Y Arizmendiarrieta
BACKGROUND: University lecturers often complain about their students’ lack of learning strategies, but not many universities in Spain offer specific courses in this area. Studies on their effectiveness are also rare. METHOD: This study presents the results of a Learning Strategies Course implemented at the School of Teacher Training and Education, University of Oviedo, Spain. A quasi-experimental design was used with an experi-mental (n = 60) and a control group (n = 57) of students on the Educational Psychology course...
November 2017: Psicothema
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