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https://www.readbyqxmd.com/read/30453404/-predictive-study-on-recurrence-of-chronic-sinusitis-with-nasal-polyps-by-tissue-eosinophils-and-sinus-ct
#1
H H Yang, H Fang, Q J You, L Han, Z F Yang, L L Yu, Y Zhang
Objective: To investigate the correlation between postoperative recurrence and clinical parameters in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), and to study predicitve value of total scores of eosinophils (EOS) and sinus CT for postoperative recurrence. Methods: A retrospective analysis of 264 patients with CRSwNP who were admitted to the First Affiliated Hospital of Wenzhou Medical University from June 2013 to December 2015 was performed. The patient was subjected to a visual analogue scale (VAS) score, a skin prick test, a peripheral blood cell count, a sinus CT score, and a nasal polyp EOS count...
November 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/30452122/inhibition-of-arachidonate-15-lipoxygenase-reduces-the-epithelial-mesenchymal-transition-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#2
Bing Yan, Yang Wang, Ying Li, Chengshuo Wang, Luo Zhang
BACKGROUND: The epithelial-mesenchymal transition (EMT) is a distinguishing characteristic of chronic rhinosinusitis with nasal polyps (CRSwNP). The underlying mechanism remains largely unknown. Arachidonate 15-lipoxygenase (ALOX15), an enzyme involved in arachidonic acid metabolism, has been reported to cause airway epithelial injury and thus may further promote the EMT. The aim of this study was to evaluate the role of ALOX15 during the EMT process in CRSwNP. METHODS: A total of 54 samples were obtained, including 10 from healthy control, 16 from non-eosinophilic CRSwNP, and 28 from eosinophilic CRSwNP...
November 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/30450917/reactive-oxygen-species-are-necessary-for-bleomycin-a5-induced-apoptosis-and-extracellular-matrix-elimination-of-nasal-polyp-derived-fibroblasts
#3
Fan Wu, Peng Tian, Yun Ma, Jingyi Wang, Huashuang Ou, Hua Zou
BACKGROUND: The pathology of chronic rhinosinusitis with nasal polyp (CRSwNP) is characterized by the infiltration of a large number of fibroblasts, resulting in extracellular matrix (ECM) deposition. Intralesional bleomycin A5 (BLE) injection has proved to be effective and safe, providing a novel treatment for CRSwNP. However, the mechanism is not clearly understood. OBJECTIVES: The aim of this study is to explore the possible mechanism of BLE-induced apoptosis in nasal polyp-derived fibroblasts (NPDFs)...
November 17, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/30449614/asthma-rhinitis-and-nasal-polyp-multimorbidities
#4
José Antonio Castillo Vizuete, Joaquín Sastre, Alfonso Del Cuvillo Bernal, César Picado, Eva Martínez Moragón, José María Ignacio García, Carolina Cisneros Serrano, Francisco Javier Álvarez Gutiérrez, Joaquim Mullol Miret
The aim of this review is to assist pulmonologists in the management of diseases involving both the upper and lower respiratory tract that are linked by a common, interrelated epidemiology, clinical signs and symptoms, and inflammatory mechanism - asthma, in particular. The document discusses the definitions of the various sinonasal phenotypes associated with asthma: allergic and non-allergic rhinitis and chronic rhinosinusitis with or without nasal polyps. Diagnostic criteria and severity levels are also listed...
November 15, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/30446829/the-ratio-of-11%C3%AE-hydroxysteroid-dehydrogenase-1-11%C3%AE-hydroxysteroid-dehydrogenase-2-predicts-glucocorticoid-response-in-nasal-polyps
#5
Lijie Jiang, Min Zhou, Jie Deng, Yueqi Sun, Kejun Zuo, Rui Zheng, Jianbo Shi, Yinyan Lai
BACKGROUND: Glucocorticoids are the first-line medical treatment for chronic rhinosinusitis with nasal polyps (CRSwNP), whose local metabolism is catalyzed by 11β-HSD1 and 11β-HSD2. This study investigates the role of 11β-HSD1 and 11β-HSD2 on the glucocorticoid response of CRSwNP patients and the pathogenic mechanism of these polyps. METHODS: Forty-three adult CRSwNP patients were enrolled in this study. We evaluated the endoscopic scores by a nasal polyp grading system before and after treatment...
November 16, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30446828/different-effects-of-allergic-rhinitis-on-nasal-mucosa-remodeling-in-chronic-rhinosinusitis-with-and-without-nasal-polyps
#6
Rong Xiang, Qing-Ping Zhang, Wei Zhang, Yong-Gang Kong, Lu Tan, Shi-Ming Chen, Yu-Qin Deng, Ze-Zhang Tao, Yu Xu
BACKGROUND: Allergic rhinitis (AR) has been reported to be associated with chronic rhinosinusitis (CRS). The objective of this study was to investigate the effect of AR on nasal mucosa remodeling in CRS. METHODS: Patients were enrolled and divided into the following groups: CRS with nasal polyps (NP) with allergic rhinitis (AR)(CRSwNPwAR; n = 20), CRS with NP without AR (CRSwNPsAR; n = 20), CRS without NP with AR (CRSsNPwAR; n = 20), CRS without NP without AR (CRSsNPsAR; n = 20), AR without CRS (AR; n = 20) and controls (n = 14)...
November 16, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30439404/cd3-cd4-cd8-mucosal-t-cells-are-associated-with-uncontrolled-chronic-rhinosinusitis-with-nasal-polyps
#7
Tanja Soklic Kosak, Mira Silar, Matija Rijavec, Ana Koren, Izidor Kern, Irena Hocevar Boltezar, Peter Korosec
Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP.
November 12, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30430853/histopathologic-features-of-chronic-sinusitis-precipitated-by-odontogenic-infection
#8
Anish Raman, Peter Papagiannopoulos, Hannah N Kuhar, Paolo Gattuso, Pete S Batra, Bobby A Tajudeen
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease process that can arise in the context of odontogenic disease from the maxillary teeth. The histopathologic features of odontogenic CRS (CRSo) have yet to be determined and may have important implications on disease management and need for escalation of therapy. OBJECTIVES: The objectives of this study are to characterize the histopathologic features of CRSo and determine whether the inflammatory profile of CRSo contributes to its recalcitrance to medical therapy and need for surgery in a subset of patients with this disease...
November 15, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/30430241/choanal-polyps-in-children-and-adults-10-year-experience-from-a-tertiary-care-hospital
#9
Aleksandar Perić, Tijana Vukadinović, Tarik Kujundžić, Milica Labus, Marko Stoiljkov, Biserka Vukomanović Đurđević
PURPOSE: Choanal polyps (CPs) are benign, solitary, soft-tissue lesions extending towards the junction between the nasal cavity and the nasopharynx through the choana. The aim of this retrospective study was to evaluate clinical and histological characteristics of CPs in children comparing to adult patients. METHODS: Characteristics of CPs treated in our hospital (demography, main complaints, side, localization, surgical approach, histological characteristics, accompanying paranasal sinus diseases, association with allergic rhinitis, postoperative follow-up period, and recurrence rates) were retrospectively reviewed...
November 14, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30428957/a-cross-sectional-population-based-survey-of-u-s-adults-with-symptoms-of-chronic-rhinosinusitis
#10
James N Palmer, John C Messina, Robert Biletch, Kirk Grosel, Ramy A Mahmoud
BACKGROUND: Chronic rhinosinusitis (CRS) is believed to create a substantial population-level disease burden in the UnitedStates due to its high prevalence and significant disease morbidity, but many studies of CRS epidemiology are based onadministrative or historical record sources rather than primary population sources. OBJECTIVE: To characterize CRS symptoms, burden, and patient characteristics by using a primary U.S. population- basedrepresentative sample. METHODS: A demographically and geographically representative sample of 10,336 U...
November 14, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/30426494/tgf%C3%AE-mediates-collagen-production-in-human-crssnp-nasal-mucosa-derived-fibroblasts-through-smad2-3-dependent-pathway-and-ctgf-induction-and-secretion
#11
Jiunn-Min Shieh, Yih-Jeng Tsai, Jessie Chao-Yun Chi, Wen-Bin Wu
Chronic rhinosinusitis without nasal polyp (CRSsNP) is characterized by tissue remodeling and fibrosis. Transforming growth factor-β (TGF-β) is considered a master switch in the induction of the profibrotic program which can induce fibroblasts to synthesize and contract extracellular matrix (ECM) proteins. A previous study has shown TGF-β1 signaling and collagen overproduction in the CRSsNP, but the responsible cells and mechanism of action remain unclear. Therefore, this study was aimed to investigate the relationship between TGF-β1 stimulation and collagen expression and to explore the role of connective tissue growth factor (CTGF) during the remodeling process using human CRSsNP nasal mucosa tissues and mucosa-derived fibroblasts as main materials...
November 13, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30412180/-the-application-of-the-hidrogel-based-medicinal-compositions-for-the-targeted-delivery-of-medications-in-rhino-and-otosurgery
#12
N D Oltarzhevskaya, I M Kirichenko, N A Khar'kova, S V Frolov
The objective of the present study was the analysis of the application of the hydrogel-based medicinal compositions for the treatment of the patients presenting with pathological changes in the nasal cavity and paranasal sinuses during the postoperative period. A total of 25 patients at the age from 18 to 60 years with the diseases of the nasal cavity and paranasal sinuses were available for the examination including 12 ones with polypous polysinusitis and 13 patients having benign neoplasms in the nasal cavity, paranasal sinuses, and the base of the skull...
2018: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/30400683/-the-role-of-mapk-signaling-pathway-in-the-repair-of-mucosal-epithelium-in-chronic-sinusitis-with-nasal-polyps-and-without-nasal-polyps
#13
T Wang, H R Zang, Y C Li, L J Li
Objective: To evaluate the differences between CRS and normal subjects and between chronic rhinosinusitis without nasal polys(CRSsNP) and chronic rhinosinusitis with nasal polys(CRSwNP) in the regulation of EGF pathways and the regulating proliferative position of MAPK pathways. Method: We evaluated the proliferation rates of ethmoidal mucosal cells before and after stimulation with EGF,epidermal growth factor receptor(EGFR) kinase inhibitor AG1478, and extracellular signalregulated kinase1/2(ERK1/2) inhibitorPD98059 using MTT assays...
November 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/30396322/accuracy-of-self-reported-diagnosis-of-chronic-rhinosinusitis
#14
Alan D Workman, Arjun K Parasher, Mariel T Blasetti, James N Palmer, Nithin D Adappa, Jordan T Glicksman
Large cohort studies of chronic rhinosinusitis (CRS) prevalence often include patients who have been inappropriately diagnosed with the disease. In this investigation, new patients presenting to a tertiary rhinology practice completed a screening questionnaire that included questions about self-reported CRS status, demographic information, and symptomatology. Treating rhinologists evaluated patients according to clinical practice guideline criteria for CRS; 91 patients were ultimately diagnosed with CRS. The sensitivity of self-report for CRS was 84%; the specificity was 82%; and the estimated negative predictive value ranged from 97% to 99%...
November 6, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/30388935/role-of-vitamin-d-and-its-receptors-in-the-pathophysiology-of-chronic-rhinosinusitis
#15
Malgorzata Tomaszewska, Elzbieta Sarnowska, Natalia Rusetska, Katarzyna Kowalik, Janusz Sierdzinski, Janusz A Siedlecki, Vladimir Badmaev, Sidney J Stohs, Mariola Popko
OBJECTIVES: Chronic rhinosinusitis (CRS) is a disease that represents a challenging therapeutic problem. Vitamin D and its receptors (VDR) are involved in the regulation of the immune system and may play role in CRS. Objectives of this study were to assess the relationships between the total concentration of vitamin D (25VD3) in sera, vitamin D receptor (VDR) expression, 1α-hydroxylase expression, and clinical data, including age, gender, Sino-Nasal Outcome Test (SNOT-22), computerized tomography (CT) scan, allergy status, and vitamin D supplementation in CRS patients with (CRSwNP) and without nasal polyps (CRSsNP), and in a control group...
November 2, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/30387011/molecular-interactions-in-juvenile-nasopharyngeal-angiofibroma-preliminary-signature-and-relevant-review
#16
Anupam Mishra, Riddhi Jaiswal, Pandey Amita, S C Mishra
BACKGROUND: The molecular profile of juvenile nasopharyngeal angiofibroma (JNA) is extremely variable. In absence of established molecular signature the molecular targeting seems difficult for this heterogeneous disease. To establish a basic molecular signature, this paper analyses the interaction of 7 markers according to their ranks as per the decreasing scale of molecular expression. MATERIALS AND METHODS: Fourteen samples of JNA were obtained following surgical excision and mRNA expressions were established through real-time polymerase chain reaction (RT-PCR) for vasculoendothelial growth factor (VEGF), fibroblastic growth factor (FGF), c-Kit, c-myc, Ras, platelet-derived growth factor (PDGF) and tumor suppressor gene p53...
November 1, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30385529/innate-lymphoid-cells-in-the-upper-airways-importance-of-cd117-and-il-1ri-expression
#17
Koen Van Crombruggen, Sylvie Taveirne, Gabriele Holtappels, Georges Leclercq, Claus Bachert
Although innate lymphoid cells (ILC)1s, ILC2s and ILC3s are emerging as important cell populations regulating tissue homeostasis, remodelling and inflammation, a vast majority of our knowledge stems from in vitro and murine experiments, and requires thorough confirmation in human diseases.Relative levels of ILCs were evaluated by means of flow cytometry in freshly resected human upper airways mucosa of patients with chronic rhinosinusitis (CRS) without nasal polyps (NP) (CRSsNP) and with nasal polyps (CRSwNP), taking into account the patient's clinical parameters and disease comorbidities...
November 1, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30383734/a-mometasone-eluting-sinus-implant-sinuva-for-nasal-polyps
#18
REVIEW
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No abstract text is available yet for this article.
September 10, 2018: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/30375439/phosphoinositide-3-kinase-delta-could-be-a-biomarker-for-eosinophilic-nasal-polyps
#19
Jong Seung Kim, Jae Seok Jeong, Kyung Bae Lee, So Ri Kim, Yeong Hun Choe, Sam Hyun Kwon, Seong Ho Cho, Yong Chul Lee
Nasal polyps (NP) cause diverse clinical symptoms of chronic rhinosinusitis (CRS). Chronic inflammation of sinonasal mucosa is known to be crucial in NP formation. We aimed to define the implications of phosphoinositide 3-kinase (PI3K)-δ in nasal inflammation associated with NP by analyzing NP tissue obtained from CRS patients. Results showed that expression of p110δ, a regulatory subunit of PI3K-δ, in NP tissue was increased compared to control tissue. Increased p110δ expression was closely correlated with more severe CRS features...
October 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30374480/single-sided-sinonasal-mass-a-retrospective-study
#20
Seyda Belli, Metin Yildirim, Sinan Eroglu, Funda Kaya Emre
OBJECTIVE: A unilateral sinonasal mass is a common pathology in ear, nose, and throat clinical practice. However, it may be confused with early stage inflammatory pathologies. The aim of this study was to examine the diagnostic histopathological, clinical, and radiological criteria for a unilateral nasal mass. METHODS: The present study examined the clinical and pathological profiles of unilateral sinonasal masses observed in patients at an ear, nose, and throat clinic in Istanbul between January 2008 and January 2016...
2018: Northern Clinics of Istanbul
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