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https://www.readbyqxmd.com/read/27922968/role-of-apoptosis-in-the-pathogenesis-of-nasal-polyps-based-upon-galectin-3-expression
#1
Taliye Cakabay, Ibrahim Sayin, Omer Erdur, Ali Muhammedoglu, Nihal Seden Tekke, Fatma Tulin Kayhan
OBJECTIVE: The authors aimed to investigate the antiapoptotic mechanisms in nasal polyps that occur after glandular hyperplasia. STUDY DESIGN: Retrospective histopathological analyses of patients with nasal polyps. METHODS: The study comprised 54 patients (19 females; 35 males). Group-1 patients with a diagnosis of nasal polyposis; group-2 patients with a diagnosis of antrochoanal polyps; group-3 with a diagnosis of deviation of the nasal septum as a control group...
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27922925/update-on-nonmalignant-lesions-of-the-inferior-turbinate
#2
Jared M Goldfarb, David Goldfarb, Marc R Rosen
PURPOSE OF REVIEW: The inferior turbinates are routinely examined by otolaryngologists on anterior rhinoscopy and nasal endoscopy. Most lesions of the inferior turbinate are benign but can often be confused with malignancy. This review highlights the broad differential of nonmalignant lesions of the inferior turbinates and their management. RECENT FINDINGS: A variety of infectious, inflammatory, neoplastic, and vascular lesions may affect the inferior turbinates...
December 5, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27895321/is-nasal-polyposis-related-to-levels-of-serum-vitamin-d-and-vitamin-d-receptor-gene-expression
#3
Omer Erdag, Mahfuz Turan, Rıfkı Ucler, Mehmet Berkoz, Mehmet Fatih Garca, Nazım Bozan, Ahmet Faruk Kıroglu, Hakan Cankaya
BACKGROUND Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP...
November 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27888916/refractory-chronic-rhinosinusitis-with-nasal-polyposis
#4
REVIEW
Benjamin P Hull, Rakesh K Chandra
Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a subset of chronic sinusitis with various causes. Some forms of the disease are driven by allergy, often in association with asthma. Refractory CRSwNP can be associated with cystic fibrosis and other clinical syndromes. More recent literature is presented regarding roles of innate immunity and superantigens. Effective treatment of CRSwNP requires careful endoscopic sinus surgery followed by an individualized treatment plan that often includes oral and topical steroids...
February 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27887817/is-there-a-role-for-regenerative-medicine-in-chronic-rhinosinusitis-with-nasal-polyps
#5
EDITORIAL
Fabiana C P Valera, Leandra M Endam, Badr Ibrahim, Emmanuelle Brochiero, Martin Y Desrosiers
No abstract text is available yet for this article.
November 2, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27885166/the-role-of-interleukin-33-in-chronic-rhinosinusitis
#6
Dong-Kyu Kim, Hong Ryul Jin, Kyoung Mi Eun, Ji-Hun Mo, Seong H Cho, Sohee Oh, David Cho, Dae Woo Kim
RATIONALE: Interleukin (IL)-33, a new member of the IL-1 family, is constitutively expressed in epithelial tissues and lymphoid organs and plays an important role in the pathogenesis of allergic disease. However, the role of IL-33 in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. OBJECTIVE: To investigate the role of IL-33 in the pathophysiology of CRSwNP. METHODS: We investigated IL-33 expression and its cellular origins in the nasal polyps (NPs) of human subjects by immunohistochemistry (IHC), quantitative reverse transcription PCR (qRT-PCR), and multiplex cytokine assays...
November 24, 2016: Thorax
https://www.readbyqxmd.com/read/27879191/replacement-of-sfc-dpi-with-sfc-mdi-exhaled-through-the-nose-improved-eosinophilic-chronic-rhinosinusitis-with-bronchial-asthma%C3%A2
#7
Yoshiki Kobayashi, Mikiya Asako, Takahisa Yamamoto, Hirotaka Yasuba, Koichi Tomoda, Akira Kanda
OBJECTIVE: Eosinophilic chronic rhinosinusitis (ECRS), a subgroup of chronic rhinosinusitis with nasal polyps, is a refractory disease closely associated with bronchial asthma. We recently reported on the efficacy of ultra-fine particle inhaled corticosteroids (ICS) (hydrofluoroalkane-134a-beclomethasone dipropionate: HFA-BDP) exhalation through the nose (ETN) treatment for mild-to-moderate asthmatics with ECRS. However, the effect of HFA-BDP ETN was found to be transient in some cases with severe ECRS and asthma, requiring treatment with higher-dose ICS and long-acting β2-agonists (LABA)...
November 23, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27870664/targeting-il-25-as-a-novel-therapy-in-chronic-rhinosinusitis-with-nasal-polyps
#8
Mingyu Lee, Dae Woo Kim, Hyun-Woo Shin
PURPOSE OF REVIEW: Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a heterogeneous inflammatory disorder with a poorly understood pathophysiology. Recent findings show that epithelial-derived cytokines, including thymic stromal lymphopoietin, IL-33, and IL-25, can exacerbate Th2 immune responses, ultimately leading to recalcitrant chronic rhinosinusitis and nasal polyp. Although IL-25 is increased in CRSwNP, the targeting of IL-25 as a therapeutic strategy remains largely unexplored...
November 18, 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27870663/dendritic-cell-subset-expression-in-severe-chronic-rhinosinusitis-with-nasal-polyps
#9
Claudina Perez-Novo, Rogério Pezato
PURPOSE OF REVIEW: Two main pillars are implicated in nasal polyposis development: a severe imbalance in immunomodulation and a mechanical dysfunction because of an abnormal remodeling process. Dendritic cells play a crucial role in the link between innate and adaptive immune response and orchestrating the T-cell response and are implicated in the severe inflammatory process found in nasal polypoid tissue. This review summarizes the existent knowledge about dendritic cells in nasal polyposis...
November 18, 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27859303/prevalence-of-polyp-recurrence-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-with-nasal-polyposis
#10
Adam S DeConde, Jess C Mace, Joshua M Levy, Luke Rudmik, Jeremiah A Alt, Timothy L Smith
OBJECTIVES/HYPOTHESIS: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a disease process that is driven, in part, by intrinsic mucosal inflammation. Surgery plus continued medical therapy is commonly elected by medically recalcitrant, symptomatic patients. The objective was to evaluate the prevalence of nasal polyp recurrence up to 18 months after endoscopic sinus surgery (ESS) with congruent continuing medical management. STUDY DESIGN: Prospective, multicenter cohort of adult patients undergoing ESS for medically recalcitrant CRSwNP performed between August 2004 and February 2015...
November 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27853500/septochoanal-polyp-with-metaplastic-ossification-mimicking-sinonasal-tumor-a-case-report
#11
Il-Young Cho, Jae-Wook Kim, Hak-Jin Kim, Kyu-Sup Cho
Choanal polyps are a form of nasal polyps that grow toward the choana with a single stalk. Septochoanal polyp is a rare entity that originates from the mucosa of the nasal septum with choanal extension. The most common site of its origin is mainly the superior aspect of the posterior portion of the nasal septum. However, metaplastic ossification is a rare event in nasal polyp and to the best of our knowledge, septochoanal polyp with metaplastic ossification has not been reported in the literature. Herein, we report a case of huge septochoanal polyp with metaplastic ossification obstructing both the nasal cavity and nasopharynx, which was successfully removed via transnasal endoscopic approach...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27849652/polyps-asthma-and-allergy-what-s-new
#12
Dimitrios Terzakis, Christos Georgalas
PURPOSE OF REVIEW: Although chronic rhinosinusitis with nasal polyps, asthma, and allergy share common inflammatory mechanisms, there is no evidence of cause-and-effect relationship. In this review, we present new studies investigating the complex immunology that links these diseases. Advances in new therapies as well as evidence regarding indication and timing of surgery, especially of more complex cases, are highlighted. RECENT FINDINGS: New studies have endotyped patients in an effort to describe the exact inflammatory profile of each phenotype, whereas described cytokines seem to play a significant role in amplification of T2 inflammation, directly or via innate lymphoid cells...
November 15, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27846022/postoperative-care-in-endoscopic-sinus-surgery-a-critical-review
#13
Philippe Eloy, Peter Andrews, Anne-Lise Poirrier
PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard treatment for medically refractive disease. Postoperative care is recommended by international leaders as an important part of the patient's management. This article is a critical review and discussion focusing on postoperative care, which is based on expert opinion, clinical studies, randomized controlled trials and meta-analysis studies...
November 14, 2016: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/27822702/effects-of-mobile-phone-wechat-services-improve-adherence-to-corticosteroid-nasal-spray-treatment-for-chronic-rhinosinusitis-after-functional-endoscopic-sinus-surgery-a-3-month-follow-up-study
#14
Shaoyan Feng, Zibin Liang, Rongkai Zhang, Wei Liao, Yuan Chen, Yunping Fan, Huabin Li
The objective of the study is to investigate the impact of receiving daily WeChat services on one's cell phone on adherence to corticosteroid nasal spray treatment in chronic rhinosinusitis (CRS) patients after functional endoscopic sinus surgery (FESS). This study was a two-arm, randomized, follow-up investigation. Patients with chronic rhinosinusitis with/without nasal polyps following bilateral FESS were randomised to receive, or to not receive, daily WeChat service on their cell phone to take corticosteroid nasal spray treatment...
November 7, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27817219/current-complications-and-treatment-of-aspirin-exacerbated-respiratory-disease
#15
Kevin A Cook, Donald D Stevenson
Aspirin-exacerbated respiratory disease is defined by the clinical tetrad of aspirin sensitivity, nasal polyps, asthma, and chronic rhinosinusitis. Patients experience acute upper and lower airway reactions with exposure to aspirin and other cyclooxygenase-1 inhibiting medications. However, airway inflammation and disease progression occur even in the absence of exposure to these medications, often leading to aggressive polyp formation and need for systemic corticosteroids to treat exacerbations in asthma and rhinosinusitis...
November 17, 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27814709/treatment-of-allergic-rhinitis-with-acupoint-herbal-plaster-an-oligonucleotide-chip-analysis
#16
Horng-Sheng Shiue, Yun-Shien Lee, Chi-Neu Tsai, Hen-Hong Chang
BACKGROUND: Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a series of acupoint herbal plaster applications. METHODS: In this experimental pilot study, volunteers experiencing sneezing, runny nose, and congestion for more than 9 months in the year following initial diagnoses were included after diagnostic confirmation by otolaryngologists to exclude patients with sinusitis and nasal polyps...
November 4, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27809696/the-impact-of-chronic-rhinosinusitis-on-long-term-survival-in-lung-transplantation-recipients
#17
Shin Kariya, Mitsuhiro Okano, Takahiro Oto, Takaya Higaki, Takenori Haruna, Yohei Noda, Kazunori Nishizaki
CONCLUSIONS: Chronic rhinosinusitis diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps 2012, not by computed tomography alone, is one of the prognostic factors affecting long-term survival in patients with lung transplantation. Endoscopic sinus surgery might play a beneficial role in the management of lung transplantation recipients with chronic rhinosinusitis. OBJECTIVE: To show the effect of paranasal sinus infection on post-lung transplantation survival...
November 4, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27809411/long-term-low-dose-macrolides-for-chronic-rhinosinusitis-in-adults-a-systematic-review-of-the-literature
#18
Andrea Lasso, Pourya Masoudian, Jason G Quinn, Juthaporn Cowan, Varant Labajian, James P Bonaparte, Shaun Kilty
BACKGROUND: Chronic Rhinosinusitis is a very common inflammatory disease that impairs quality of life and is associated with high healthcare spending. Chronic rhinosinusitis treatment commonly involves the use of intranasal corticosteroids, oral antibiotics and surgery. Macrolides have been identified as a potential treatment option for chronic rhinosinusitis due to their immunomodulatory effects; however the evidence supporting their use is still conflicting. OBJECTIVE: The purpose of this systematic review was to evaluate new evidence along with previously reported studies of the use of macrolides in the treatment of chronic rhinosinusitis...
November 3, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27807867/increase-of-poorly-proliferated-p63-ki67-basal-cells-forming-multiple-layers-in-the-aberrant-remodeled-epithelium-in-nasal-polyps
#19
Li Zhao, Ying Ying Li, Chun Wei Li, Siew Shuen Chao, Jing Liu, Ha Nguyen Nam, Dung Nguyen Thi Ngoc, Li Shi, De Yun Wang
BACKGROUND: Aberrant epithelial remodeling with the ectopic expression of p63 (basal cell markers) is an important pathologic phenomenon seen in chronically inflamed airway epithelium such as in nasal polyps (NPs). METHODS: Biopsies were obtained from 55 NP patients and 18 healthy controls (inferior turbinate). Among NP patients, fifteen were treated with oral and nasal steroids, so that two sets of NPs biopsies were taken before and after the treatments. p63, Ki67, type IV β-tubulin and cell-cycle markers were investigated in these specimens...
November 2, 2016: Allergy
https://www.readbyqxmd.com/read/27804083/chronic-rhinosinusitis-with-nasal-polyps-is-associated-with-chronic-otitis-media-in-the-elderly
#20
Seung-No Hong, Woo Hyun Lee, Seung Hoon Lee, Chae-Seo Rhee, Chul Hee Lee, Jeong-Whun Kim
Chronic rhinosinusitis (CRS) and chronic otitis media (COM) are common diseases in the otorhinolaryngology field. Although clinicians frequently encounter patients presenting both diseases simultaneously, a few studies have shown relationships between them. We examined whether CRS was associated with COM in adults who participated in the Korea National Health and Nutrition Examination Survey from 2009 to 2012. A total of 27,492 participants were examined in this cross-sectional epidemiological study. Regression analyses was performed and adjusted for socio-demographics, general health behavior, and other comorbidities...
November 1, 2016: European Archives of Oto-rhino-laryngology
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