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Nasal polyp

Jungik Park, Grace Choi, Mi-Jin Yim, Jeong Min Lee, Jong Su Yoo, Won Sun Park, Seong Kook Park, Saegwang Park, Su-Kil Seo, Tae-Geum Kim, Dae-Sung Lee, Il-Whan Choi
Phlorotannins (PTNs), a group of phenolic compounds from seaweeds, have diverse bioactivities. However, there has been no report on their antifibrotic effects during nasal polyp (NP) formation. In the present study, the effect of PTNs on transforming growth factor (TGF)‑β1‑induced profibrotic responses in nasal polyp‑derived fibroblasts (NPDFs) were determined and the relevant signaling pathways were investigated. The expression levels of collagen type‑1 (Col‑1) and fibronectin in NP tissues were measured by western blot analysis and immunohistochemistry...
July 12, 2018: International Journal of Molecular Medicine
Jordan T Glicksman, Arjun K Parasher, Laurel Doghramji, David Brauer, Jeremy Waldram, Kristen Walters, Jeff Bulva, James N Palmer, Nithin D Adappa, Andrew A White, John V Bosso
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic rhinosinusitis, nasal polyps, asthma, and respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to sensitivity to aspirin and NSAIDs, the majority of patients with AERD have been reported to have respiratory intolerance associated with the consumption of alcohol. METHODS: A multicenter prospective cohort study was performed...
July 10, 2018: International Forum of Allergy & Rhinology
Farhad Seif, Babak Ghalehbaghi, Hossein Aazami, Alireza Mohebbi, Aslan Ahmadi, Reza Falak, Pegah Babaheidarian, Mohammad Najafi, Majid Khoshmirsafa, Sahand Ghalehbaghi, Mehdi Shekarabi
Background: Chronic Rhinosinusitis (CRS) is a persistent inflammatory disease affecting paranasal sinuses. CRS is categorized into two distinct subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Although several immune cells are involved in the CRS pathogenesis, the role of T cells is not fully understood. The objective of the present study was to evaluate the frequency of CD4+ and CD8+ T cells and macrophages in the sinonasal mucosa of CRS patients, as well as to investigate the specific transcription factors for Th1, Th2, Th17, and Treg cells...
2018: Allergy, Asthma, and Clinical Immunology
Jaleh Yousefi, Hojat Madarshahi, Asghar Akhavan, Abolfazl Taheri, Masoumeh Saeedi, Ali Bagherihagh, Mohammad Ali Hosseini, Mohammad Hossein Khosravi
OBJECTIVES: Chronic rhinosinusitis (CRS) is characterized by a long-time inflammatory disease of nasal and sinus mucosa. Olfactory dysfunction is common among CRS patients with a prevalence ranging from 48% to 83%. We aimed to assess the effect of ESS on olfactory function of patients with chronic rhinosinusitis without nasal polyps. METHOD: This randomized clinical trial was conducted on 30 patients with chronic rhinosinusitis without nasal polyps. Patients were randomly allocated to two intervention and control groups; patients in intervention group underwent endoscopic sinus surgery by a single surgeon and control group continued standard treatment with nasal irrigation of normal saline (4 times daily) and nasal corticosteroids (one puff in each nostril daily)...
June 1, 2018: International Tinnitus Journal
Haiyu Hong, Dan Wang, Kai Sen Tan, Rui Zheng, Fenghong Chen, Wenxiang Gao, Haixin He, Jianbo Shi, Yunping Fan, Qintai Yang, Yueqi Sun
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease usually characterized by chronic eosinophilia in the sinonasal mucosa, which often requires glucocorticoid (GC) therapy. However, the therapeutic response varies markedly between individuals. The objective of this study was to evaluate the diagnostic values of sinus computed tomography (CT) for GC-sensitivity in patients with CRSwNP. Methods: We conducted a prospective, single-blinded study of 47 consecutive patients with CRSwNP...
2018: Clinical and Translational Allergy
A Rouyar, M Classe, R Gorski, M-D Bock, J le-Guern, S Roche, V Fourgous, A Remaury, P Paul, C Ponsolles, D Françon, L Rocheteau-Beaujouan, M Clément, E-B Haddad, J-C Guillemot, M Didier, B Biton, C Orsini, V Mikol, M Leonetti
BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a chronic inflammatory disease often accompanied by impairment of sense of smell. This symptom has been somewhat overlooked and its relationship to inflammatory cytokines, tissue compression, neuronal loss, and neurogenesis is still unclear. METHODS: In order to elucidate potential mechanisms leading to CRS in humans, we have established a Type 2/T helper type 2 cell (Th2)-mediated allergic CRS mouse model, based on house dust mite (HDM) and Staphylococcus aureus enterotoxin B (SEB) sensitization...
July 10, 2018: Allergy
Saeed Zanganeh, Hamideh Rouhani Nejad, Jalil Fallah Mehrabadi, Razieh Hosseini, Bahareh Shahi, Zahra Tavassoli, Asieh Aramvash
Staphylococcal enterotoxin B, from Staphylococcus aureus (S. aureus), is one of the most potent bacterial superantigens with profound toxic effects on the immune system. It is associated with food poisoning, toxic shock, atopic dermatitis, asthma, and nasal polyps in humans. The current diagnostic methods for staphylococcal enterotoxin are mainly based on traditional monoclonal antibodies which hardly meet the requirements for clinical applications, and hybridoma clones lose their ability to secrete antibodies during time...
July 9, 2018: Applied Biochemistry and Biotechnology
Thomas Koch, Martin Ptok
BACKGROUND: Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in Germany and is often accompanied by years of chronic rhinosinusitis. According to the current German guideline "Rhinosinusitis", the nasal application of salt solutions, topical corticosteroids and in individual cases also systemic corticosteroids appear useful for a symptomatic therapy of CRS. The evidence for other therapeutic procedures such as acupuncture, homeopathy and phytotherapeutics is seen as insufficient...
July 6, 2018: Laryngo- Rhino- Otologie
Siddharth Gautam Singh, Sadat Qureshi, Leena Jain, Shalini Jadia, Sandeep Sharma
A variety of non-neoplastic and neoplastic conditions involve the nasal cavity, paranasal sinus and are fairly common presentation encountered in clinical practice. Sinonasal lesions are a common finding in all age groups. The lesion of nose and paranasal sinuses are very deceptive so, the presenting features, clinical examination, nasal endoscopy, radiodiagnosis and histopathology are employed conjointly to reach a diagnosis. This cross sectional study was conducted between November 2014 and September 2016...
June 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
O Ismi, T Kara, G Polat, O Bobusoglu, Y Vayısoglu, K Gorur, C Ozcan
BACKGROUND: Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis. METHODS: The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa...
July 5, 2018: Journal of Laryngology and Otology
Nicholas R Rowan, Zachary M Soler, Florence Othieno, Kristina A Storck, Timothy L Smith, Rodney J Schlosser
BACKGROUND: Genetic variation of the bitter taste receptor T2R38 has been associated with recalcitrant chronic rhinosinusitis (CRS). Specific T2R38 polymorphisms, correlating with bitter taste sensitivity to phenylthiocarbamide (PTC), have been identified as an independent risk factor for surgical intervention in CRS patients without polyps; however, the exact role of PTC tasting ability in clinical practice remains unknown. In this investigation we characterize PTC taste sensitivity in a tertiary care rhinology practice with pertinent clinical measures of disease and quality of life (QOL)...
July 4, 2018: International Forum of Allergy & Rhinology
Mahdi Niknami, Mahdi Mirmohammadi, Azade Pezeshki
Objectives: Mucous retention pseudocyst (MRP) of the maxillary sinus is an incidental finding on radiographs. The radiographs taken for dental purposes provide an opportunity for dentists to recognize asymptomatic maxillary sinus anomalies. The purpose of this study was to determine the prevalence of MRP on panoramic and cone-beam computed tomography (CBCT) views and to evaluate the associated risk factors. Materials and Methods: In this study, 710 panoramic radiographs and 90 CBCT scans were examined with regard to the presence of MRP in the maxillary sinus during 2014-15...
March 2018: Journal of Dentistry of Tehran University of Medical Sciences
Francesco Antonio Salzano, Luigi Marino, Giovanni Salzano, Riccardo Maria Botta, Giovanni Cascone, Umberto D'Agostino Fiorenza, Carmine Selleri, Vincenzo Casolaro
The prevalence of reactive nasal inflammatory conditions, for example, allergic rhinitis and chronic rhinosinusitis, is steadily increasing in parallel with significant environmental changes worldwide. Allergens and as yet undefined environmental agents may trigger these conditions via the involvement of host intrinsic factors, including the innate and adaptive immune system, the nasal epithelium, and the nasal nervous system. The critical role of the nasal microbiota in coordinating these components has emerged in recent studies documenting a significant association between microbial composition and the onset and progression of allergic or nonallergic inflammation...
2018: Journal of Immunology Research
A S Lopatin, O A Ivanchenko, S S Soshnikov, J Mullol
Chronic rhinosinusitis (CRS) is an inflammatory disease of the nose and paranasal sinuses affecting 11% of the European population. Cyclamen europaeum plant extract (CE) has demonstrated efficacy in treating acute rhinosinusitis, but its role in CRS exacerbations remains unknown. In this real-life, prospective, epidemiological, observational study, a total of 317 patients with exacerbations of CRS without nasal polyps (CRSsNP) of moderate severity were treated using three different options: oral antibiotics, CE extract nasal spray, or the combination of oral antibiotic with CE extract...
April 2018: Acta Otorhinolaryngologica Italica
Masanori Kidoguchi, Emiko Noguchi, Takako Nakamura, Takahiro Ninomiya, Wataru Morii, Kanako Yoshida, Taiyo Morikawa, Yukinori Kato, Yoshimasa Imoto, Masafumi Sakashita, Tetsuji Takabayashi, Shigeharu Fujieda
Background Nasal polyps (NP) are characterized by pseudocysts derived from stromal tissue edema and cause persistent infections in patients with chronic rhinosinusitis (CRS). A low level of tissue-type plasminogen activator (gene name PLAT) is considered a cause of stromal tissue edema because of insufficient plasmin activation in NP; however, the mechanism regulating PLAT gene expression levels is still unclear. The epigenetic mechanism regulating the PLAT gene expression has been studied in other tissues...
January 1, 2018: American Journal of Rhinology & Allergy
Dawei Wu, Sarina K Mueller, Angela L Nocera, Kristen Finn, Towia A Libermann, Benjamin S Bleier
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by type 2 helper T-cell-skewed immune profiles, but the state of the neutrophil activation signaling pathway in CRSwNP is unknown. The purpose of this study was to examine neutrophil activation pathways in the pathogenesis of CRSwNP. Methods Institutional review board approved the study in which tissue proteomes were compared between control (inferior turbinate) and CRSwNP (nasal polyps) (n = 10/group) using an aptamer-based proteomic array and confirmed by whole transcriptomic analysis...
January 1, 2018: American Journal of Rhinology & Allergy
Hae Dong Kim, Ick Soo Choi
Extranasopharyngeal angiofibroma (ENA) is an angiofibroma that occurs in the extranasopharynx. It shows pathologic findings, such as juvenile angiofibroma (JNA), which accounts for 0.5% of head and neck mass. However, compared with JNA, the prevalence, affected site, and clinical characteristics are completely different, which leads some physicians to classify ENA as a disease different from JNA. ENA of the nasal turbinate origin are rarely reported in the literature. In addition, choanal polyp originating from the posterior part of the nasal turbinate is uncommonly reported...
June 25, 2018: Auris, Nasus, Larynx
Kiyoshi Hirahara, Kenta Shinoda, Yusuke Endo, Tomomi Ichikawa, Toshinori Nakayama
Background: Immunological memory is critical for long-standing protection against microorganisms; however, certain antigen-specific memory CD4+ T helper (Th) cells drive immune-related pathology, including chronic allergic inflammation such as asthma. The IL-5-producing memory-type Tpath2 subset is important for the pathogenesis of chronic allergic inflammation. This memory-type pathogenic Th2 cell population (Tpath2) can be detected in various allergic inflammatory lesions. However, how these pathogenic populations are maintained at the local inflammatory site has remained unclear...
2018: Inflammation and Regeneration
Diego Antonio Mena Canata, Fernanda Schäfer Hackenhaar, Tiago Boeira Salomon, Ártur Krumberg Schüller, Guilherme Luis Franche da Silva, Cassiano Teixeira, Mara Silveira Benfato
PURPOSE: Nasal polyposis is a chronic inflammatory disease of the mucosa of the nasal cavity and paranasal sinuses. The etiology of nasal polyposis is unclear; however, it may be associated with asthma and intolerance to acetylsalicylic acid, possibly altering the redox profile. The study intends to compare the redox profile in polyps surgically removed from three clinical groups of patients with nasal polyposis who were divided according to the presence of asthma and intolerance to acetylsalicylic acid...
June 11, 2018: European Archives of Oto-rhino-laryngology
Amin Amali, Ziba Bidar, Sara Rahavi-Ezabadi, Narges Mikaniki, Seyed Mousa Sadrehosseini
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) affects approximately 4% of general population. Patients with CRSwNP have greater burden of CRS symptoms and higher rate of relapse after either medical or surgical treatments. The aim of this study was to evaluate the association between polypoid change of anterior free border of middle turbinate and rate of relapse in patients with CRSwNP. METHODS: A controlled prospective cohort study was performed...
June 9, 2018: European Archives of Oto-rhino-laryngology
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