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https://www.readbyqxmd.com/read/30216703/pro-inflammatory-role-of-transient-receptor-potential-canonical-channel-6-in-the-pathogenesis-of-chronic-rhinosinusitis-with-nasal-polyps
#1
Ru Tang, Zhi-Peng Li, Ming-Xian Li, Da-Wei Li, Hai-Bo Ye, Kai-Ming Su, Hai Lin, Wei-Tian Zhang
BACKGROUND: The pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) has not been fully elucidated. This study sought to explore the role and mechanism of transient receptor potential canonical channel 6 (TRPC6) in the pathogenesis of CRSwNP. METHODS: Immunohistochemistry (IHC) was employed to evaluate TRPC6 immunolabeling. Real-time polymerase chain reaction (PCR) was conducted to assay TRPC6, stromal interaction molecule 1 (STIM1), and calcium release-activated calcium channel protein 1 (Orai1) messenger RNA (mRNA) levels in 70 patients with CRSwNP, including eosinophilic CRSwNP (ECRSwNP) or non-eosinophilic CRSwNP (nECRSwNP), and 28 control subjects...
September 14, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/30216468/diagnosis-and-management-of-nsaid-exacerbated-respiratory-disease-n-erd-a-eaaci-position-paper
#2
Marek L Kowalski, Ioana Agache, Sevim Bavbek, Arzu Bakirtas, Miguel Blanca, Grażyna Bochenek, Matteo Bonini, Enrico Heffler, Ludger Klimek, Tanya M Laidlaw, Joaquim Mullol, Ewa Niżankowska-Mogilnicka, Hae-Sim Park, Marek Sanak, Mario Sanchez- Borges, Silvia Sanchez-Garcia, Glenis Scadding, Masami Taniguchi, Maria J Torres, Andrew A White, Aleksandra Wardzyńska
NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and /or chronic rhinosinusitis with nasal polyps (CRSwNP), symptoms of which are exacerbated by NSAIDs, including aspirin. Despite some progress in understanding of the pathophysiology of the syndrome, which affects 1/10 of patients with asthma and rhinosinusitis, it remains a diagnostic and therapeutic challenge. In order to provide evidence-based recommendations for the diagnosis and management of N-ERD a panel of international experts was called by the EAACI Asthma Section...
September 14, 2018: Allergy
https://www.readbyqxmd.com/read/30199594/topical-and-systemic-antifungal-therapy-for-chronic-rhinosinusitis
#3
REVIEW
Karen Head, Steve Sharp, Lee-Yee Chong, Claire Hopkins, Carl Philpott
BACKGROUND: This review adds to a series of reviews looking at primary medical management options for patients with chronic rhinosinusitis.Chronic rhinosinusitis is common and characterised by inflammation of the lining of the nose and paranasal sinuses leading to nasal blockage, nasal discharge, facial pressure/pain and loss of sense of smell. The condition can occur with or without nasal polyps. Antifungals have been suggested as a treatment for chronic rhinosinusitis. OBJECTIVES: To assess the effects of systemic and topical antifungal agents in patients with chronic rhinosinusitis, including those with allergic fungal rhinosinusitis (AFRS) and, if possible, AFRS exclusively...
September 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30199582/glucocorticoids-ameliorate-periostin-induced-tissue-remodeling-in-chronic-rhinosinusitis-with-nasal-polyps
#4
Hyun-Woo Yang, Joo-Hoo Park, Jae-Min Shin, Heung-Man Lee
BACKGROUND: Periostin plays an important role in the development of chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP). Glucocorticoids (GCs) are anti-inflammatory drugs used to treat CRS, but the mechanism for inhibiting periostin-induced tissue remodeling is still unclear. We sought to investigate the expression of periostin, α-SMA, and extracellular matrix (ECM) components in sinonasal tissues and to evaluate the inhibitory mechanism of GCs in nasal fibroblasts and mucosa. METHODS: We measured the expression of periostin, α-SMA and ECM components in sinonasal tissues...
September 10, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/30196345/massive-juvenile-polyposis-of-the-stomach-in-a-family-with-smad4-gene-mutation
#5
Maurizio Ponz de Leon, Monica Pedroni, Alessandra Viel, Claudio Luppi, Rita Conigliaro, Federica Domati, Giuseppina Rossi, Luca Reggiani Bonetti
Relatively little is known on the genotype-phenotype correlations between SMAD4 gene mutations, juvenile polyposis of the intestine and Hereditary Hemorrhagic Teleangectasia. We describe a family in which the proband (a 46-year old woman) had massive polyposis of the stomach-leading to surgery-with high-grade dysplasia at histology. Molecular analysis was carried out using Next Generation sequencing techniques with Miseq Illumina Platforms and a minimal coverage of 40 reads. In the proband, the analysis showed the presence of a truncating mutation in the SMAD4 gene (c...
September 8, 2018: Familial Cancer
https://www.readbyqxmd.com/read/30195458/diagnostic-criteria-in-pai-syndrome-results-of-a-case-series-and-a-literature-review
#6
A Morice, E Galliani, J Amiel, M Rachwalski, C Neiva, C Thauvin-Robinet, M-P Vazquez, A Picard, N Kadlub
Pai syndrome was originally described as the association of a midline cleft lip, midline facial polyps, and lipoma of the central nervous system. However, only a few patients present with the full triad, and most exhibit a wide spectrum of phenotypic variability. The aim of this study was to phenotypically delineate Pai syndrome and to propose new criteria to facilitate a clinical diagnosis in the future. The study cohort consisted of seven case patients and an additional 60 cases diagnosed with Pai syndrome identified in a literature review...
September 5, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30193937/staphylococcus-aureus-nasal-colonization-and-asthma-in-adults-systematic-review-and-meta-analysis
#7
Young-Chan Kim, Ha-Kyeong Won, Ji Won Lee, Kyoung-Hee Sohn, Min-Hye Kim, Tae-Bum Kim, Yoon-Seok Chang, Byung-Jae Lee, Sang-Heon Cho, Claus Bachert, Woo-Jung Song
BACKGROUND: Staphylococcus aureus (SA) is a frequent colonizer in human and it is known to be associated with chronic allergic diseases including asthma. Recent individual studies suggested that nasal SA colonization may be positively associated with asthma. OBJECTIVE: To examine relationships between nasal SA colonization and asthma prevalence and activity in adults. METHODS: Electronic databases were searched for studies published until June 2018...
September 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/30193936/effects-of-reslizumab-on-asthma-outcomes-in-a-subgroup-of-eosinophilic-asthma-patients-with-self-reported-chronic-rhinosinusitis-with-nasal-polyps
#8
Steven F Weinstein, Rohit K Katial, Philip Bardin, Stephanie Korn, Mirna McDonald, Margaret Garin, Eric D Bateman, Flavia C L Hoyte, Matthew Germinaro
BACKGROUND: An estimated 7% of patients with asthma have chronic rhinosinusitis with nasal polyps (CRSwNP) and over 80% have at least some radiographic evidence of sinonasal inflammation. Aspirin sensitivity is strongly associated with elevated blood eosinophil levels and increased asthma severity. Intravenous (IV) reslizumab has been shown to improve asthma control in patients with nasal polyps. OBJECTIVE: These post-hoc analyses of pooled data from two BREATH phase 3 clinical trials, studies 1 and 2 (NCT01287039 and NCT01285323), examined asthma-related outcomes in patients with comorbid, self-reported CRSwNP with and without aspirin sensitivity...
September 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/30187339/cdk5-regulates-pd-l1-expression-and-cell-maturation-in-dendritic-cells-of-crswnp
#9
C C Liu, H L Zhang, L L Zhi, P Jin, L Zhao, T Li, X M Zhou, D S Sun, G H Cheng, Q Xin, L Shi, M Xia
The maturation of dendritic cells is critical for chronic rhinosinusitis with nasal polyps (CRSwNPs), especially eosinophilic chronic rhinosinusitis with nasal polyps (EosCRSwNPs), but the regulation mechanism of dendritic cells (DCs) maturation is still unclear. We identified nasal mucosa of 20 patients with EosCRSwNP, 16 non-EosCRSwNP patients, and inferior turbinate of 14 patients with nasal septum deviation after surgery. The expression of cyclin-dependent kinase 5 (CDK5) and programmed cell death 1 ligand 1 (PD-L1) were detected by immunofluorescent, real-time quantitative PCR, and Western blot in EosCRSwNP...
September 5, 2018: Inflammation
https://www.readbyqxmd.com/read/30184244/withdrawn-topical-and-systemic-antifungal-therapy-for-the-symptomatic-treatment-of-chronic-rhinosinusitis
#10
REVIEW
Peta-Lee Sacks, Richard J Harvey, Janet Rimmer, Richard M Gallagher, Raymond Sacks
BACKGROUND: Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and sinuses. Since fungi were postulated as a potential cause of CRS in the late 1990s, there has been increasing controversy about the use of both topical and systemic antifungal agents in its management. Although interaction between the immune system and fungus has been demonstrated in CRS, this does not necessarily imply that fungi are the cause of CRS or that antifungals will be effective its management...
September 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30167718/-immunology-of-chronic-rhinosinusitis-with-nasal-polyps-as-a-basis-for-treatment-with-biologicals
#11
REVIEW
L Klimek, M Koennecke, J Hagemann, B Wollenberg, S Becker
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammation of the nasal and paranasal mucosa. Until now, no internationally standardized classification could be developed. In most cases, CRS is phenotypically classified according to chronic rhinosinusitis with (CRScNP) and without nasal polyps (CRSsNP). However, recent studies could show that there are numerous endotypes within these phenotypes based on different inflammatory mechanisms. This review describes the important immunological mechanisms of CRScNP and highlights modern treatment options with biologicals directly addressing particular immunological processes...
August 30, 2018: HNO
https://www.readbyqxmd.com/read/30156212/is-sino-nasal-outcome-test-22-reliable-for-guiding-chronic-rhinosinusitis-patients-for-endoscopic-sinus-surgery
#12
G Singla, M Singh, A Singh, I Kaur, K Harsh, K Jasmeen
Chronic rhino-sinusitis (CRS) is a significant health problem whose incidence and prevalence is rising. An emphasis has been placed on diseasespecific quality of life (QoL as the predominant measure for most current outcome studies. Therefore a validated measure of health-related QoL in sinonasal disease is needed. The present prospective and observational study was conducted on 50 patients in the Department of ENT at Govt. Medical College and Rajindra Hospital Patiala, Punjab, India. The primary outcomes were the following: (1) the chance of attaining minimal clinically important difference (MCID) improvements of nine points at the 22-item Sino-Nasal Outcome Test (SNOT-22) after endoscopic sinus surgery (ESS) for different preoperative QoL levels, and (2) the percentage of relative improvement in SNOT-22 after ESS for different preoperative QoL levels...
September 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/30152239/understanding-the-propensity-for-chronic-sinusitis-in-patients-on-immunosuppressive-therapy
#13
Peter Papagiannopoulos, Hannah N Kuhar, Anish Raman, Ashwin Ganti, Paolo Gattuso, Pete S Batra, Bobby A Tajudeen
Background Chronic rhinosinusitis (CRS) is a frequently observed condition in patients with immunodeficiency secondary to immunosuppressive medications. The histologic features of CRS among patients undergoing immunosuppressive treatment have yet to be determined and may have important implications on understanding the pathophysiology of the disease process. Methods A structured histopathology report was utilized to analyze sinus tissue removed during functional endoscopic sinus surgery (FESS). Histopathology variables, Lund-Mackay score (LMS), and sinonasal outcome test 22 scores were compared among patients with CRS on immunosuppressive therapy (CRSi), CRS without nasal polyps (CRSsNP) patients, and CRS with nasal polyps (CRSwNP) patients...
August 28, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/30142324/h3n2-influenza-virus-infection-enhances-oncostatin-m-expression-in-human-nasal-epithelium
#14
Tengfei Tian, Xiaoxue Zi, Yang Peng, Zhaoni Wang, Haiyu Hong, Yan Yan, Weijie Guan, Kai Sen Tan, Jing Liu, Hsiao Hui Ong, Xue Kang, Jieqing Yu, Yew Kwang Ong, Kim Thye Thong, Li Shi, Jing Ye, De-Yun Wang
Tight junctions (TJs) alteration is commonly seen in airway inflammatory diseases. Oncostatin M (OSM) is an inflammatory mediator associated with chronic rhinosinusitis with nasal polyps (CRSwNP). We have previously shown that human nasal epithelial cells (hNECs) are highly permissive cells for influenza A virus (IAV). However, its role in TJs alteration and the effects of IAV on inducing OSM expression in nasal epithelium remains to be further investigated. In this study, OSM and TJs expression was measured and compared between inferior turbinate from healthy controls and nasal polyps from CRSwNP...
August 22, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30138520/chronic-otitis-media-with-effusion-in-chronic-sinusitis-with-polyps
#15
Mary Daval, Hervé Picard, Emilie Bequignon, Philippe Bedbeder, André Coste, Denis Ayache, Virginie Escabasse
The relationship between otitis media with effusion (OME) and chronic rhinosinusitis with nasal polyposis (CRSwNP) remains unclear. We conducted a cross-sectional study of 80 consecutively presenting patients-42 males and 38 females, aged 15 to 76 years (median: 48)-who were diagnosed with CRSwNP. Our aim was to ascertain the prevalence of OME in CRSwNP patients, to determine whether the severity of CRSwNP affected OME, and to identify risk factors for OME in CRSwNP patients. The severity of CRSwNP was assessed on the basis of nasal symptoms, endoscopic nasal examinations, and Lund-Mackay staging scores...
August 2018: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/30136707/comparison-of-efficacy-of-fluticasone-propionate-versus-clarithromycin-for-postoperative-treatment-of-different-phenotypic-chronic-rhinosinusitis-a-randomized-controlled-trial
#16
M Zeng, H Wang, B Liao, H Wang, X B Long, J Ma, J X Liu, P P Cao, Q Ning, Z Liu
BACKGROUND: Chronic rhinosinusitis (CRS) can be divided to CRS without nasal polyps (CRSsNP) and eosinophilic and non-eosinophilic CRS with nasal polyps (CRSwNP). There is little evidence on the efficacy of glucocorticoids and macrolides in different phenotypic patients. The aim of this study was to compare the benefit of glucocorticoids and macrolides following endoscopic sinus surgery (ESS) in different phenotypic CRS. METHODS: This study was a prospective single-blind comparative effectiveness trial...
August 23, 2018: Rhinology
https://www.readbyqxmd.com/read/30135581/allergic-inflammatory-memory-in-human-respiratory-epithelial-progenitor-cells
#17
Jose Ordovas-Montanes, Daniel F Dwyer, Sarah K Nyquist, Kathleen M Buchheit, Marko Vukovic, Chaarushena Deb, Marc H Wadsworth, Travis K Hughes, Samuel W Kazer, Eri Yoshimoto, Katherine N Cahill, Neil Bhattacharyya, Howard R Katz, Bonnie Berger, Tanya M Laidlaw, Joshua A Boyce, Nora A Barrett, Alex K Shalek
Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases1 . Specialized subsets of epithelial cells-including secretory and ciliated cells-differentiate from basal stem cells to collectively protect the upper airway2-4 . Allergic inflammation can develop from persistent activation5 of type 2 immunity6 in the upper airway, resulting in chronic rhinosinusitis, which ranges in severity from rhinitis to severe nasal polyps7 . Basal cell hyperplasia is a hallmark of severe disease7-9 , but it is not known how these progenitor cells2,10,11 contribute to clinical presentation and barrier tissue dysfunction in humans...
August 2018: Nature
https://www.readbyqxmd.com/read/30126769/increased-expression-of-pendrin-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#18
Taku Ito, Satoshi Ikeda, Tomoaki Asamori, Keiji Honda, Yoshiyuki Kawashima, Ken Kitamura, Keiko Suzuki, Takeshi Tsutsumi
INTRODUCTION: Chronic rhinosinusitis with nasal polyps is a heterogeneous disease and appropriate diagnostic algorithms in individual cases are necessary for effective medical treatment. OBJECTIVE: The purpose of this study was to clarify the relationship between the pendrin expression of nasal polyps and clinical and pathological characteristic features of eosinophilic chronic rhinosinusitis. METHODS: A total of 68 patients were classified into eosinophilic chronic rhinosinusitis or non-eosinophilic chronic rhinosinusitis groups according to the degree of eosinophilic infiltration into the nasal polyps...
August 7, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/30126729/feasibility-study-of-bilateral-radical-ethmoidectomy-in-ambulatory-surgery
#19
M Kérimian, P-L Bastier, N Réville, S Fierens, L de Gabory
OBJECTIVES: To assess the feasibility of bilateral radical ethmoidectomy in ambulatory surgery by risk analysis, and to calculate possible medico-economic savings. METHODS: This study was performed retrospectively over a 2-year period and prospectively for 1 year. It included all patients undergoing bilateral ethmoidectomy, associated to sphenoidotomy and/or septoplasty or not, in a university hospital department. Data were collected on demographics, disease etiology, previous surgery, operative details, postoperative course, complications and satisfaction assessed by questionnaire at days 1 and 30...
August 17, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/30124489/role-of-allergen-specific-t-follicular-helper-cells-in-immunotherapy
#20
Yin Yao, Zhi-Chao Wang, Di Yu, Zheng Liu
PURPOSE OF REVIEW: The discovery of novel T-cell subsets including follicular helper T (Tfh) cells has broadened our knowledge on the complex immune networks in allergic diseases. This review summarizes the evidence for Tfh cells in controlling immune responses to allergens with a particular focus on immunoglobulin E (IgE) production and discusses the implication of such regulation in allergen-specific immunotherapy. RECENT FINDINGS: Tfh cells support the production of IgE in animal models for allergic diseases...
August 18, 2018: Current Opinion in Allergy and Clinical Immunology
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