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antibiotics endocarditis

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https://www.readbyqxmd.com/read/29337066/listeria-monocytogenes-endocarditis-case-report-review-of-the-literature-and-laboratory-evaluation-of-potential-novel-antibiotic-synergies
#1
Monika Kumaraswamy, Carter Do, George Sakoulas, Poochit Nonejuie, Guan Woei Tseng, Helen King, Joshua Fierer, Joe Pogliano, Victor Nizet
Endocarditis is a rare but serious manifestation of Listeria monocytogenes (LM). However, the optimal treatment strategy for LM endocarditis has yet to be established. Current antibiotic strategies for listeriosis include penicillin G or ampicillin (AMP) monotherapy, or AMP + gentamicin combination therapy which is often favored for endocarditis. The primary objective of our investigation was to assess the utility of AMP + ceftriaxone (CRO) and AMP + daptomycin (DAP) against LM, modeling less nephrotoxic antibiotic combinations traditionally used to manage resistant enterococcal endocarditis...
January 11, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29333818/community-acquired-methicillin-resistant-staphylococcus-aureus-infections-hospitalization-and-case-fatality-risk-in-10-pediatric-facilities-in-argentina
#2
Ángela Gentile, Julia Bakir, Gabriela Ensinck, Aldo Cancellara, Enrique V Casanueva, Verónica Firpo, Martín Caruso, María F Lución, Alejandro Santillán Iturres, Fabiana Molina, Héctor J Abate, Andrea Gajo Gane, Santiago López Papucci
INTRODUCTION: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are prevalent both in Argentina and worldwide, and they may have a severe clinical course. OBJECTIVES: To estimate the hospitalization rate and case fatality risk factors of CA-MRSA infection. METHODS: Cross-sectional, analytical study. All patients < 15 years old with community-acquired Staphylococcus aureus (CA-SA) infections admitted to 10 pediatric facilities between January 2012 and December 2014 were included...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29329519/eikenella-corrodens-endocarditis-and-liver-abscess-in-a-previously-healthy-male-a-case-report
#3
Anne Christine Nordholm, Ruth Ottilia Birgitta Vøgg, Henrik Permin, Terese Katzenstein
BACKGROUND: Eikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male. CASE PRESENTATION: A 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission there was elevated white blood cell count and C-reactive protein, as well as affected liver function tests...
January 12, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29326959/use-of-antibiotic-prophylaxis-for-tooth-extractions-dental-implants-and-periodontal-surgical-procedures
#4
Katie J Suda, Heather Henschel, Ursula Patel, Margaret A Fitzpatrick, Charlesnika T Evans
Background: Guidelines for antibiotics prior to dental procedures for patients with specific cardiac conditions and prosthetic joints have changed, reducing indications for antibiotic prophylaxis. In addition to guidelines focused on patient comorbidities, systematic reviews specific to dental extractions and implants support preprocedure antibiotics for all patients. However, data on dentist adherence to these recommendations are scarce. Methods: This was a cross-sectional study of veterans undergoing tooth extractions, dental implants, and periodontal procedures...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29326076/phage-derived-lysins-as-potential-agents-for-eradicating-biofilms-and-persisters
#5
REVIEW
Umender Sharma, Aradhana Vipra, Shankaramurthy Channabasappa
Bacterial biofilms are highly resistant to the action of antibiotics. Presence of persisters, phenotypically resistant populations of bacterial cells, is thought to contribute toward recalcitrance of biofilms. The phage-derived lysins, by virtue of their ability to cleave the peptidoglycan of bacterial cells in an enzymatic manner, have the unique ability to kill dormant cells. Several lysins have shown potent antibiofilm activity in vitro. The fact that lysins have shown better efficacy than conventional drugs in animal models of endocarditis and other infections involving biofilms suggests that the lysins can potentially be developed against difficult-to-treat bacterial infections...
January 8, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29324478/site-of-entry-and-surgical-timing-in-infective-endocarditis
#6
Francesco Bovenzi, Lucia Borelli, Lauro Cortigiani
: Infective endocarditis is the manifestation of the endocardial involvement during a systemic infectious process.The prognosis of this condition is still dismal, and the mortality associated with it remains high despite improvement in antimicrobial treatment. Antibiotic prophylaxis is still recommended only in high-risk cases, that is, procedures at high risk for inducing systemic bacteremia.It is important to provide an educational prophylaxis consisting of sound hygienic recommendations for the cleansing of the oral cavity, the skin, genital-urinary, and gastrointestinal systems...
January 10, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29313584/an-interesting-case-of-recurrent-pyelonephritis
#7
Achintya Dinesh Singh, Siddharth Jain, Agrima Mian, Surabhi Vyas, Neeraj Nischal, Pankaj Jorwal
A 35-year-old male presented with repeated episodes of fever and abdominal pain of 3-month duration. He had been hospitalized twice with similar complaints in the past 3-month. He was diagnosed as pyelonephritis and managed with intravenous antibiotics. However, fever recurred after ten days of discharge from the hospital. With these complaints, he was referred to the Department of Medicine, AIIMS, New Delhi. After evaluation, he was diagnosed as pyelonephritis with right sided consolidation and was started on broad spectrum antibiotics...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29299896/infective-endocarditis-presenting-as-endogenous-endophthalmitis-secondary-to-streptococcus-agalactiae-in-a-healthy-adult-case-reports-and-literature-review
#8
Yu Ra Sim, Ye Jin Lee, Seung Woon Park, Sang Hyun Kim, Ju Hee Choi, Jung Yoon Choi, Min Ja Kim, Jang Wook Sohn, Jaemoon Ahn, Young Kyung Yoon
Endogenous endophthalmitis secondary to group B Streptococcus (GBS) is extremely rare, particularly in healthy adults. However, the visual prognosis is poor. We report the first South Korean case of GBS infective endocarditis presenting as endogenous endophthalmitis and skin and soft tissue infection. Cultures of blood, vitreous humor, and pus from skin aspirates yielded a penicillin-susceptible serotype V strain of Streptococcus agalactiae. After 6 weeks, the patient completely recovered from GBS infective endocarditis...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29296269/clinicomicrobiological-spectrum-of-infective-endocarditis-from-a-tertiary-care-centre-in-south-india
#9
Kanne Padmaja, Sukanya Sudhaharan, Lakshmi Vemu, Oruganti Sai Satish, Padmasri Chavali, Mamidi Neeraja
Background and Objectives: Infective endocarditis (IE) is a microbial infection of the endothelial surface of the cardiac-valves. Rapid diagnosis, effective treatment and prompt recognition of complications are essential, in order to improve the outcome. We retrospectively reviewed and determined the clinical characteristics, microbiological profile and management strategies of IE cases, changing microbial spectrum of pathogens and outcome in Native Valve Endocarditis (NVE) and Prosthetic Valve Endocarditis (PVE) cases...
October 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29284415/streptococcus-agalactiae-infective-endocarditis-complicated-by-multiple-mycotic-hepatic-aneurysms-and-massive-splenic-infarction-a-case-report
#10
Pietro Achilli, Angelo Guttadauro, Paolo Bonfanti, Sabina Terragni, Luca Fumagalli, Ugo Cioffi, Francesco Gabrielli, Matilde De Simone, Marco Chiarelli
BACKGROUND: The burden of disease caused by Streptococcus agalactiae has increased significantly among older adults in the last decades. Group B streptococcus infection can be associated with invasive disease and severe clinical syndromes, such as meningitis and endocarditis. CASE PRESENTATION: We present the case of a 56-year-old man who developed multiple mycotic aneurysms of the right hepatic artery and massive splenic infarction as rare complications of Streptococcus agalactiae infective endocarditis...
December 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29250041/stenotrophomonas-maltophilia-as-an-emerging-ubiquitous-pathogen-looking-beyond-contemporary-antibiotic-therapy
#11
REVIEW
Anthony A Adegoke, Thor A Stenström, Anthony I Okoh
Stenotrophomonas maltophilia is a commensal and an emerging pathogen earlier noted in broad-spectrum life threatening infections among the vulnerable, but more recently as a pathogen in immunocompetent individuals. The bacteria are consistently being implicated in necrotizing otitis, cutaneous infections including soft tissue infection and keratitis, endocarditis, meningitis, acute respiratory tract infection (RTI), bacteraemia (with/without hematological malignancies), tropical pyomyositis, cystic fibrosis, septic arthritis, among others...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29249792/-valve-replacement-for-infective-endocarditis-of-pulmonary-valve-report-of-a-case
#12
Azuma Tabayashi, Tatsuhiko Komiya, Hiroshi Tsuneyoshi, Takeshi Simamoto, Jiro Sakai, Toshifumi Hiraoka, Takashi Kawashima, Kenji Wada, Hiroyuki Kaneko, Yuka Fujimoto, Taiyo Jinno, Osamu Tominaga
Generally, infective endocarditis is found at the left side of the heart. The right side infective endocaritis accounts for only 5~10% of all cases of infective endocarditis. The right side infective endocarditis occurs especially among drug users employing intravenous injection. A typical site of infection is the tricupid valve, and isolated pulmonary valve involvement is rare. It is assumed that its rarity is due to the low pressure gradients within the right heart, the low prevalence of valve disease, and the lower oxygen content of the venous blood...
December 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29238620/angiovac-system-used-for-vegetation-debulking-in-a-patient-with-tricuspid-valve-endocarditis-a-case-report-and-review-of-the-literature
#13
Hossam Abubakar, Ahmed Rashed, Ahmed Subahi, Ahmed S Yassin, Mohamed Shokr, Mahir Elder
AngioVac is a vacuum-based device approved in 2014 for percutaneous removal of undesirable materials from the intravascular system. Although numerous reports exist with regard to the use of the AngioVac device in aspiration of iliocaval, pulmonary, upper extremity, and right-sided heart chamber thrombi, very few data are present demonstrating its use in treatment of right-sided endocarditis. In this case report, we describe the novel device used in debulking a large right-sided tricuspid valve vegetation reducing the occurrence of septic embolisation and enhancing the efficacy of antibiotics in clearance of bloodstream infection...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29238455/in-vitro-activity-of-recombinant-lysostaphin-in-combination-with-linezolid-vancomycin-and-oxacillin-against-methicillin-resistant-staphylococcus-aureus
#14
Nagalakshmi Narasimhaswamy, Indira Bairy, Gautham Shenoy, Laxminarayana Bairy
Background and Objectives: The antimicrobial combination with synergistic mechanism is recommended to provide broad-spectrum coverage, and prevent the emergence of resistant mutants. In the present study, the synergistic activity of lysostaphin with linezolid, oxacillin and vancomycin, against methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates was determined. Materials and Methods: Seventy-three MRSA isolates collected from clinical specimens were tested, for in vitro synergistic activity of lysostaphin with linezolid, vancomycin and oxacillin, by checkerboard assay...
August 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29238103/clinical-features-of-patients-with-infective-endocarditis-presenting-to-the-emergency-department-a-retrospective-case-series
#15
Naruhiro Jingushi, Mitsunaga Iwata, Teruhiko Terasawa
Infective endocarditis (IE) is an uncommon clinical problem with diverse, nonspecific presentations. Therefore, information on the clinical features of IE patients presenting to emergency departments (EDs) is scarce. To descriptively analyze the pertinent data, we performed a retrospective chart review. We reviewed 15 consecutive IE patients admitted directly from ED in a university hospital in Japan between 2013 and 2015. We compared their clinical features with those of 14 IE patients admitted during the same period without ED presentations...
November 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29234970/aortic-valve-reconstruction-using-autologous-pericardium-ozaki-procedure-for-active-infective-endocarditis-a-case-report
#16
Kimiaki Okada, Yoshito Inoue, Hirofumi Haida, Satoru Suzuki
Approximately one-third of patients with infective endocarditis require surgical treatment, but the ideal procedure that prevents infection ensures long durability and maintains quality of life remains unclear. A 21-year-old man who was diagnosed with aortic active infective endocarditis was referred to our hospital for surgical treatment. Echocardiography showed bicuspid aortic valve, severe aortic regurgitation, a large vegetation, and a paravalvular abscess. We planned to perform elective surgical treatment after antibiotic therapy; however, progression to heart failure required urgent operation...
December 12, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29233359/supra-annular-mitral-valve-replacement-in-an-infant-with-infective-endocarditis
#17
Sanae Yamauchi, Shigemitsu Iwai, Yuji Tominaga, Yosuke Kugo, Moyu Hasegawa, Futoshi Kayatani, Kunihiko Takahashi, Hisaaki Aoki, Hiroaki Kawata
We report the case of a female neonate born at 40 weeks' gestation with no known risk factors. On postnatal day 27, she was transferred to the pediatric intensive care unit and intubated for cardiorespiratory failure; she was diagnosed with group B streptococcus infective endocarditis. Mitral valve vegetations did not improve with antibiotic therapy. Mitral valve surgery was performed on postnatal day 36. A mechanical mitral valve with short-segment polytetrafluoroethylene skirt was inserted into the supra-annular position; gentian violet was applied to the sewing ring and skirt...
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29232248/endocarditis-in-the-setting-of-idu-multidisciplinary-management
#18
Bobby Yanagawa, Anees Bahji, Wiplove Lamba, Darrell H Tan, Asim Cheema, Ishba Syed, Subodh Verma
PURPOSE OF REVIEW: The purpose of this article is to provide a brief overview of the medical and surgical management of infective endocarditis secondary to IDU, with a focus on the underlying substance use disorder. RECENT FINDINGS: Patients with infective endocarditis secondary to IDU are often young with unique comorbidities including mental illness, chronic hepatitis C, HIV infection, which are often compounded by limited social and familial supports. The focus of management has been treatment of endocarditis using IV antibiotics alongside surgery...
December 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29231172/cefazolin-and-coagulation-disorders-a-case-report
#19
Eugénie Gay, Anne Barthel, Nicolas Rouzic, Basile Henriot, Baptiste Quélennec, Aurélien Lorleac'h, Nathalie Prades, François Schmitt
We report the case of a 79-year-old patient, admitted to the department of infectious diseases at Bretagne Sud Hospital Center for a right calcaneal osteitis, complicated by a pacemaker leads infectious endocarditis. Meticillin sensitive Staphylococcus aureus was documented by blood culture. Antibiotic treatment was established using intravenous cefazolin for an initial 6 weeks period. Prothrombin time (PT) decreased as well as vitamin K dependent factors, without anticoagulation therapy, at day 7 of cefazolin treatment...
December 12, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29229070/infective-endocarditis-an-update-for-dental-surgeons
#20
REVIEW
Andrew Narendran Robinson, Paul Anantharajah Tambyah
Infective endocarditis (IE) is associated with significant morbidity and mortality. The prevention of infective endocarditis, for many years, has involved the identification of at risk patients undergoing medical or dental procedures and the use of pre-procedural antibiotic prophylaxis. However, evidence regarding the effectiveness of such measures is lacking while evidence is mounting for the adverse effects of inappropriate antibiotic use. International guidelines for antibiotic prophylaxis were amended, radically in some cases to reflect this...
December 2017: Singapore Dental Journal
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