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Placental thickness

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https://www.readbyqxmd.com/read/29671605/effects-of-budesonide-and-surfactant-in-preterm-fetal-sheep
#1
T Brett Kothe, Emily Royse, Matthew W Kemp, Augusto F Schmidt, Fabrizio Salomone, Masatoshi Saito, Haruo Usuda, Shimpei Watanabe, Gabrielle C Musk, Alan H Jobe, Noah H Hillman
BACKGROUND: Mechanical ventilation causes lung injury and systemic inflammatory responses in preterm sheep, and is associated with bronchopulmonary dysplasia (BPD) in preterm infants. Budesonide added to surfactant decreased BPD by 20% in infants. OBJECTIVE: Determine the effects of budesonide and surfactant on injury from high tidal volume (VT) ventilation in preterm lambs. METHODS: Ewes at 125 {plus minus} 1 day GA had fetal surgery to expose fetal head and chest with placental circulation intact...
April 19, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29669946/pravastatin-therapy-during-preeclampsia-prevents-long-term-adverse-health-effects-in-mice
#2
Nicola Garrett, Joaquim Pombo, Michelle Umpierrez, James E Clark, Mark Simmons, Guillermina Girardi
Preeclampsia (PE), associates with long-term increased risk for cardiovascular disease in women, suggesting that PE is not an isolated disease of pregnancy. It is not known if increased risk for long-term diseases is due to PE-specific factors or to prepregnancy renal and cardiovascular risk factors. We used a mouse model in which a WT female with normal prepregnancy health develops PE to investigate if preeclampsia causes long-term cardiovascular consequences after pregnancy for mothers and offspring. Mothers exhibited endothelial dysfunction and hypertension after PE and had glomerular injury that not only persisted but deteriorated, leading to fibrosis...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29593442/combined-thickness-of-the-uterus-and-placenta-and-ultrasonographic-examinations-of-uteroplacental-tissues-in-normal-pregnancy-placentitis-and-abnormal-parturitions-in-heavy-draft-horses
#3
Yuki Kimura, Shingo Haneda, Takahiro Aoki, Hidefumi Furuoka, Wataru Miki, Natsuko Fukumoto, Motozumi Matsui, Yasuo Nambo
The combined thickness of the uterus and placenta (CTUP) and ultrasonographic images of uteroplacental tissues were investigated in 35 pregnant heavy draft horses in Months 7-12 of pregnancy. The mares were divided into three groups: those pathologically diagnosed as placentitis (placentitis group, n=3); those who had abortion, premature birth, or fetal malformation (abnormal group, n=7); and those who had no abnormal findings (normal group, n=25). In the normal group, CTUP increased as pregnancy progressed from Months 7 (median, 7...
2018: Journal of Equine Science
https://www.readbyqxmd.com/read/29567300/fetal-sex-need-for-insulin-and-perinatal-outcomes-in-gestational-diabetes-mellitus-an-observational-cohort-study
#4
Stefano Raffaele Giannubilo, Angela Pasculli, Chiara Ballatori, Alessandra Biagini, Andrea Ciavattini
PURPOSE: This was a prospective observational cohort study that aimed to determine whether fetal sex influences the maternal and fetal outcomes of gestational diabetes mellitus (GDM). METHODS: In this study, 327 European primiparous women were consecutively recruited after diagnosis of GDM. AUC on the oral glucose tolerance test (OGTT), need for insulin therapy, maternal and obstetrical outcomes, and fetal fat mass (by measuring the thickness of the anterior abdominal subcutaneous tissue) were recorded and compared between the two subgroups of female and male fetuses...
March 19, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29522144/aqueous-humor-cytokine-levels-and-anatomic-response-to-intravitreal-ranibizumab-in-diabetic-macular-edema
#5
Roxane J Hillier, Elvis Ojaimi, David T Wong, Michael Y K Mak, Alan R Berger, Radha P Kohly, Peter J Kertes, Farzin Forooghian, Shelley R Boyd, Kenneth Eng, Filiberto Altomare, Louis R Giavedoni, Rosane Nisenbaum, Rajeev H Muni
Importance: Variability in response to anti-vascular endothelial growth factor (VEGF) treatment in diabetic macular edema (DME) remains a significant clinical challenge. Biomarkers could help anticipate responses to anti-VEGF therapy. Objectives: To investigate aqueous humor cytokine level changes in response to intravitreal ranibizumab therapy for the management of DME, and to determine the association between baseline aqueous levels and anatomic response. Design, Setting, and Participants: In this prospective multicenter cohort study, 49 participants with diabetes mellitus complicated by center-involving DME, with a central subfield thickness of 310 μm or greater on spectral-domain optical coherence tomography (SD-OCT), were recruited from December 22, 2011, to June 13, 2013 and statistical analysis were performed from March 1, 2017, to June 1, 2017...
March 8, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29462630/pitfalls-in-assessing-chorioamnionicity-novel-observations-and-literature-review
#6
REVIEW
Jing Lu, Yvonne Kwun Yue Cheng, Yuen Ha Ting, Kwok Ming Law, Tak Yeung Leung
Accurate diagnosis of chorioamnionicity in multiple pregnancies is the key to appropriate clinical management of multiple gestation. Although prenatal ultrasound assessment of chorioamnionicity is well established and highly accurate if performed in early pregnancy, exceptions and artifacts arise from anatomic variations in multiple pregnancies and unusual sonographic features do exist. We have summarized our own experiences and reports from the literature on these pitfalls as follows: (1) Discordant fetal sex in monochorionic pregnancies due to sex chromosome abnormalities, genital malformation in one fetus, or dizygotic twins forming a monochorionic placenta; (2) Separate placental masses in monochorionic pregnancies due to bipartite placenta; (3) False negative and false positive λ sign can arise for various reasons, and in partial monochorionic / dichorionic placentas both T and λ sign may co-exist; (4) Intrauterine synechia appearing as a thick and echogenic intrauterine septum may lead to erroneous diagnosis of dichorionic twins; (5) Errors in ascertaining amnionicity by the visualization of thin inter-twin amniotic membranes and the number of yolk sacs...
February 17, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29460316/light-and-scanning-electron-microscopy-of-the-olfactory-mucosa-in-the-rufous-sengi-elephantulus-rufescens
#7
B M Kavoi
Sengis are eutherian insectivores belonging to superorder Afrotheria, a recently defined clade of mammals that diverged from other placentals over 100 million years ago. In this study, a histological and ultrastructural analysis was carried out on the olfactory mucosa (OM) of the rufous sengi (Elephantulus rufescens) and the data were compared with those reported earlier in the dog (Canis familiaris) and the sheep (Ovis aries), whose dietary lifestyles are carnivorous and herbivorous, respectively. Qualitatively, the microstructure of the sengi's OM was basically similar to that of the other eutherian mammals except for differences in the pattern of cilia projection from the dendritic knobs of the olfactory receptor neurons (ORNs) and distribution of Bowman's glands within the lamina propria of the OM...
February 19, 2018: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/29458215/factors-associated-with-placental-vascularization-measured-by-3d-power-doppler-ultrasonographic-sphere-biopsy-between-11-and-14-weeks-of-gestation
#8
Suzanne Demers, Amelie Boutin, Regina Dembickaja, Mercedes Campanero, Kypros Nicolaides
OBJECTIVE: Preeclampsia is associated with placental vascularization disorders. Ultrasonographic sphere biopsy (USSB) of the placenta can estimate the vascularization of the placenta and potentially the risk of preeclampsia. We aimed to explore the factors related to placental vascularization measured with USSB in the first trimester. STUDY DESIGN: A prospective cohort was conducted in women recruited at 11 to 14 weeks. Three-dimensional acquisition of the placenta with power Doppler was undertaken along with crown-rump length (CRL)...
February 19, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29416421/rediscovery-and-amended-descriptions-of-begonia-kingdon-wardii-begoniaceae-from-north-myanmar
#9
Wen-Hong Chen, Xiao-Hua Jin, Yu-Min Shui
Begonia kingdon-wardii Tebbitt was rediscovered in 2014 from Myanmar after 67 years based on its last collection in 1937. Its previously unknown female flower and inaccurate morphology of leaf and ovary have been additionally described. This species belongs to Begonia sect. Sphenanthera (Hassk.) Warb. due to its dioecious habit, 3-locular ovary, berry fruits and thick placenta segments. Morphologically, it is similar to Begonia gulinqingensis S. H. Huang & Y. M. Shui in the leaf shape, placentation and fruit shape, but different in its dioecious plants, pliciform leaves, two-petalled female flowers and berry fruits...
2018: PhytoKeys
https://www.readbyqxmd.com/read/29385477/excessive-backfat-of-sows-at-109-d-of-gestation-induces-lipotoxic-placental-environment-and-is-associated-with-declining-reproductive-performance
#10
Y F Zhou, T Xu, A L Cai, Y H Wu, H K Wei, S W Jiang, J Peng
This study investigated the influence of sow backfat thickness at 109 d of gestation on sow and piglet performance. Data from 846 farrowing multiparous Yorkshire sows with parity from 3 to 5 were collected from a pig breeding farm. Sows were divided into six groups based on backfat thickness (≤ 16, 17-18, 19-20, 21-22, 23-24, and ≥ 25 mm) at 109 d of gestation. The evaluation of reproductive performance included the litter size, litter weight at birth and at weaning of 21 d, weight of placenta at parturition, placental efficiency, and sow daily feed intake of lactation...
January 27, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29351577/effects-of-excess-thromboxane-a2-on-placental-development-and-nutrient-transporters-in-a-mus-musculus-model-of-fetal-growth-restriction
#11
Karen J Gibbins, Katherine N Gibson-Corley, Ashley S Brown, Matthew Wieben, Richard C Law, Camille M Fung
Hypertensive disease of pregnancy (HDP) with placental insufficiency is the most common cause of fetal growth restriction (FGR) in the developed world. Despite the known negative consequences of HDP both to the mother and fetus, little is known about the longitudinal placental changes that occur as HDP progresses in pregnancy. This is because longitudinal sampling of human placentae during each gestation is impossible. Therefore, using a mouse model of thromboxane A2-analog infusion to mimic human HDP in the last trimester, we calculated placental efficiencies based on fetal and placental weights, quantified spongiotrophoblast and labyrinth thicknesses and vascular density within these layers, examined whether hypoxia signaling pathway involving vascular endothelial growth factor A (VEGFA) and its receptors (VEGFR1, VEGFR2) and matrix metalloproteinases (MMPs) contributed to vascular change, and examined nutrient transporter abundance including glucose transporters 1 and 3 (GLUT1, GLUT3), neutral amino acid transporters 1, 2, and 4 (SNAT1, SNAT2, and SNAT4), fatty acid transporters 2 and 4 (FATP2, FATP4) and fatty acid translocase (CD36) from embryonic day 15...
January 17, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29335435/placental-morphology-is-associated-with-maternal-depressive-symptoms-during-pregnancy-and-toddler-psychiatric-problems
#12
Marius Lahti-Pulkkinen, Melissa Jane Cudmore, Eva Haeussner, Christoph Schmitz, Anu-Katriina Pesonen, Esa Hämäläinen, Pia M Villa, Susanna Mehtälä, Eero Kajantie, Hannele Laivuori, Rebecca M Reynolds, Hans-Georg Frank, Katri Räikkönen
Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86)...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29245303/viable-placental-allograft-as-a-biological-dressing-in-the-clinical-management-of-full-thickness-thermal-occupational-burns-two-case-reports
#13
Eric L Johnson, Elisabet K Tassis, Georgina M Michael, Susan G Whittinghill
RATIONALE: Occupational burn injuries can be detrimental and difficult to manage. The majority of complex cases are referred and managed at regional burn centers where access to specialized care is available. As an alternative to hospitalization with staged surgical procedures, placental products may be used for outpatient medical management of these common burn injuries, especially if access to a regional burn center is limited or restricted.Fresh amnion has been a treatment of choice in burns for more than 100 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29193660/preterm-birth-with-placental-evidence-of-malperfusion-is-associated-with-cardiovascular-risk-factors-after-pregnancy-a-prospective-cohort-study
#14
J M Catov, M F Muldoon, S E Reis, R B Ness, L N Nguyen, J-M Yamal, H Hwang, W T Parks
OBJECTIVE: Preterm birth (PTB) is associated with excess maternal cardiovascular disease risk. We considered that women with PTB and placental evidence of maternal malperfusion would be particularly affected. DESIGN: Pregnancy cohort study. SETTING: Pittsburgh, PA, USA. POPULATION: Women with PTB (n = 115) and term births (n = 210) evaluated 4-12 years after pregnancy. METHODS: Cardiometabolic risk markers were compared in women with prior PTB versus term births; pre-eclampsia and growth restriction cases were excluded...
November 28, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29169625/ovarian-embryonal-carcinoma-in-a-dog
#15
B Banco, R Ferrari, D Stefanello, D Groppetti, A Pecile, S Faverzani, M Longo, D D Zani, G Ravasio, M Caniatti, V Grieco
A 17-month-old female doberman pinscher was referred for an abdominal mass and ascites. Exploratory laparotomy revealed the presence of a large neoplastic mass replacing the right ovary and associated with multiple mesovarian, mesometrial and peritoneal nodules. An ovariohysterectomy was performed. Grossly, the tumour was soft and multilocular with large areas of haemorrhage and necrosis. Microscopically, it was infiltrative and composed of round and polygonal cells arranged respectively in solid sheets or forming distorted tubular structures separated by thick fibrovascular septae...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29156171/the-use-of-decellularized-human-placenta-in-full-thickness-wound-repair-and-periarticular-soft-tissue-reconstruction-an-update-on-regenerative-healing
#16
REVIEW
Stephen A Brigido, Scott C Carrington, Nicole M Protzman
Prolonged or incomplete healing of the foot and ankle can pose significant challenges. Therefore, investigators have begun searching for alternative treatment strategies. With advances in tissue engineering, decellularized human placental connective tissue matrix has been suggested as a means to achieve more rapid and complete healing for various soft tissue and bone procedures. Basic science and clinical studies have shown that decellularized human placental connective tissue matrix can support regenerative healing through cellular migration, accelerated tissue remodeling, and the establishment of functional tissue...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29125114/antenatal-sonographic-diagnosis-and-clinical-significance-of-placenta-previa-accreta-after-cesarean-section
#17
Zhen-Zhen Liu, Yao Wei, Ruo-Jiao Wang, Wen Xu, Zhi-Min Shi, Qing Dai
Objective To investigate the clinical and antenatal sonographic characteristics of placenta previa accreta after cesarean section. Methods The data of 21 inpatients diagnosed as placenta previa accreta after cesarean section in PUMC Hospital from 2006 to 2016 were retrospectively reviewed. The clinical and ultrasound features were recorded and compared among three placental accreta groups,including placenta accrete group(n=5),increta group(n=12),and percreta group(n=4). The relationship between the placental thickness at the uterine anterior lower segment level and the blood loss of the following cesarean section was tested...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29079565/essentiality-of-regulator-of-g-protein-signaling-6-and-oxidized-ca2-calmodulin-dependent-protein-kinase-ii-in-notch-signaling-and%C3%A2-cardiovascular-development
#18
Bandana Chakravarti, Jianqi Yang, Katelin E Ahlers-Dannen, Zili Luo, Heather A Flaherty, David K Meyerholz, Mark E Anderson, Rory A Fisher
BACKGROUND: Congenital heart defects are the most common birth defects worldwide. Although defective Notch signaling is the major cause of mouse embryonic death from cardiovascular defects, how Notch signaling is regulated during embryonic vasculogenesis and heart development is poorly understood. METHODS AND RESULTS: Regulator of G protein signaling 6 (RGS6)-/-/Ca2+/calmodulin-dependent protein kinase II (CaMKII)VV double mutant mice were developed by crossing RGS6-/- mice with mice expressing an oxidation-resistant CaMKIIδ (CaMKIIVV), and the resulting embryonic defects/lethality were investigated using E7...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29069339/is-placental-malaria-a-long-term-risk-factor-for-mild-malaria-attack-in-infancy-revisiting-a-paradigm
#19
Olivier Bouaziz, David Courtin, Gilles Cottrell, Jacqueline Milet, Gregory Nuel, André Garcia
Background: Children born to mothers with placental malaria (PM) have been described as more susceptible to the occurrence of a first malaria infection. However, whether or not these children remain more at risk during infancy has never been explored. We aimed to determine if children born to mothers with PM are more susceptible to malaria and remain at higher risk between birth and 18 months. Methods: 550 children were weekly followed-up with control of temperature and, if >37...
October 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29046476/tracking-mesenchymal-stem-cell-contributions-to-regeneration-in-an-immunocompetent-cartilage-regeneration-model
#20
Daniela Zwolanek, María Satué, Verena Proell, José R Godoy, Kathrin I Odörfer, Magdalena Flicker, Sigrid C Hoffmann, Thomas Rülicke, Reinhold G Erben
It is currently controversially discussed whether mesenchymal stem cells (MSC) facilitate cartilage regeneration in vivo by a progenitor- or a nonprogenitor-mediated mechanism. Here, we describe a potentially novel unbiased in vivo cell tracking system based on transgenic donor and corresponding immunocompetent marker-tolerant recipient mouse and rat lines in inbred genetic backgrounds. Tolerance of recipients was achieved by transgenic expression of an immunologically neutral but physicochemically distinguishable variant of the marker human placental alkaline phosphatase (ALPP)...
October 19, 2017: JCI Insight
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