rheumatoid arithritis

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The distribution of joint lesions in rats with Salmonella-associated arthritis (SSA), as determined in a detailed survey, resembles to a great extent the pattern of small joint involvement in human rheumatoid arthritis. Such lesions, though regularly induced in the rat by the intravenous injection of live S.enteritidis, could not be evoked by the heat-killed organisms injected by various routes with and without extrinsic adjuvants. Efforts to transfer SAA from sensitized donors to either normal or primed recipients, employing lymphoid ce-ls from several sources, also failed repeatedly...

The criteria for selecting and establishing a animal model for arthritis were described. Rats are the most frequently used animals. Adjuvant and Myocobacterium induced arthritis provide a model of chronic joint inflammation, although significant differences exist when compared with human disease. A better model of arthritis in rats and mice can be induced by the injection of one strain of Mycoplasma arthritidis. An even better model is presented by rabbits first immunized against a protein such as heterologous fibrin or albumin, and then challenged by the same protein injected directly into a joint...