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Remote ischemic conditioning

Chung Ho Leung, Christopher A Caldarone, Rui Guan, Xiao-Yan Wen, Menachem Ailenberg, Andras Kapus, Katalin Szaszi, Ori D Rotstein
AIMS: Remote ischemic conditioning (RIC) protects against organ ischemia/reperfusion injury in experimental and clinical settings. We have demonstrated that RIC prevents liver and lung inflammation/injury following hemorrhagic shock/resuscitation (S/R). In the current study, we used a murine model of S/R to investigate the role of Nrf2 in mediating hepatoprotection. RESULTS: The combination of RIC with S/R caused a synergistic rise in Nrf2 and its translocation to the nucleus in the liver...
November 7, 2018: Antioxidants & Redox Signaling
Petra Kleinbongard, Nilguen Gedik, Mücella Kirca, Leanda Stoian, Ulrich Frey, Afsaneh Zandi, Matthias Thielmann, Heinz Jakob, Jürgen Peters, Markus Kamler, Gerd Heusch
Background Remote ischemic preconditioning ( RIPC ) by repeated brief cycles of limb ischemia/reperfusion attenuates myocardial ischemia/reperfusion injury. We aimed to identify a functional parameter reflecting the RIPC -induced protection in human. Therefore, we measured mitochondrial function in right atrial tissue and contractile function of isolated right atrial trabeculae before and during hypoxia/reoxygenation from patients undergoing coronary artery bypass grafting with RIPC or placebo, respectively...
August 7, 2018: Journal of the American Heart Association
Helmut Raphael Lieder, Petra Kleinbongard, Andreas Skyschally, Helene Hagelschuer, William M Chilian, Gerd Heusch
RATIONALE: The signal transduction of remote ischemic conditioning is still largely unknown. OBJECTIVE: Characterization of neurohumoral signal transfer and vago-splenic axis in remote ischemic preconditioning (RIPC). METHODS AND RESULTS: Anesthetized pigs were subjected to 60 minutes of coronary occlusion and 180 minutes of reperfusion (placebo+ischemia/reperfusion [PLA+I/R]). RIPC was induced by 4×5/5 minutes of hindlimb I/R 90 minutes before coronary occlusion (RIPC+I/R)...
October 26, 2018: Circulation Research
Jun Chong, Heerajnarain Bulluck, En Ping Yap, Andrew Fw Ho, William A Boisvert, Derek J Hausenloy
Acute myocardial infarction (AMI) and the heart failure (HF) that often results are among the leading causes of death and disability in the world. As such, novel strategies are required to protect the heart against the detrimental effects of acute ischemia/reperfusion injury (IRI), in order to reduce myocardial infarct (MI) size and prevent the onset of HF. The endogenous cardioprotective strategy of remote ischemic conditioning (RIC), in which cycles of brief ischemia and reperfusion are applied to a tissue or organ away from the heart, has been reported in experimental studies to reduce MI size in animal models of acute IRI...
August 2018: Conditioning medicine
Rafael Inácio Brandão, Ricardo Zanetti Gomes, Luana Lopes, Filipe Silva Linhares, José Carlos Rebuglio Vellosa, Katia Sabrina Paludo
BACKGROUND: The aim of this study was to evaluate the effects of the antioxidant allopurinol and ischemic post-conditioning on the deleterious effects of ischemia followed by reperfusion (I/R) in a standardized model of ischemia involving infra-renal aortic occlusion in rats. METHODS: The animals were randomly divided into five groups: (A) animals not subjected to ischemia; (B) animals subjected to 2 h of ischemia and reperfusion only once; (C) animals given an allopurinol dose by gavage, then subjected to 2 h of ischemia and reperfusion only once; (D) animals subjected to 2 h of ischemia and post-conditioning and (E) animals that received allopurinol, then subjected to 2 h of ischemia and post-conditioning...
October 8, 2018: Therapeutic Advances in Cardiovascular Disease
Khalid Mt Ahmed, Shannon Hernon, Sara Mohamed, Muhammed Tubassum, Michael Newell, Stewart R Walsh
OBJECTIVE: To evaluate Remote ischaemic preconditioning in management of intermittent claudication patients BACKGROUND: Animal data suggest that remote ischaemic conditioning (RIC) can improve blood flow in ischaemic limbs and, consequently, may benefit claudication patients Supervised exercise is the preferred first-line intervention for patients with intermittent claudication (IC) but is constrained by limited availability and logistical issues, particularly in rural settings METHODS: We undertook a randomised clinical trial to evaluate RIC's effect in claudication patients...
September 29, 2018: Annals of Vascular Surgery
Avisek Majumder, Mahavir Singh, Akash K George, Rubens Petit Homme, Anwesha Laha, Suresh C Tyagi
Higher levels of nonprotein amino acid homocysteine (Hcy), that is, hyperhomocysteinemia (HHcy) (~5% of general population) has been associated with severe vasculopathies in different organs; however, precise molecular mechanism(s) as to how HHcy plays havoc with body's vascular networks are largely unknown. Interventional modalities have not proven beneficial to counter multifactorial HHcy's effects on the vascular system. An ancient Indian form of exercise called 'yoga' causes transient ischemia as a result of various body postures however the cellular mechanisms are not clear...
September 11, 2018: Journal of Cellular Biochemistry
Changhong Ren, Ning Li, Sijie Li, Rongrong Han, Qingjian Huang, Jiangnan Hu, Kunlin Jin, Xunming Ji
Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral hypoperfusion (CCH), is a critical reason for the pathogenesis of vascular dementia and Alzheimer's disease characterized by cognitive impairments. Our previous study demonstrated that limb remote ischemic conditioning (LRIC) improved cerebral perfusion in intracranial arterial stenosis patients. The current study aimed to test whether LRIC promotes angiogenesis and increases phosphorylated endothelial nitric oxide synthase (p-eNOS) activity in CCH rat model...
October 2018: Aging and Disease
Nina Kumowski, Tobias Hegelmaier, Jonas Kolbenschlag, Tina Mainka, Beate Michel-Lauter, Christoph Maier
BACKGROUND: The early phase of complex regional pain syndrome (CRPS) is characterized by an inflammatory state and therefore often treated with anti-inflammatory acting glucocorticoids. Recently, we demonstrated that remote ischemic conditioning (RIC), a cyclic application of non-damaging ischemia on a remote extremity, reduces blood flow and increases oxygen extraction in the CRPS-affected extremity. AIM: Aim of the presented study was to analyze the effect of short-term pain treatment including glucocorticoid pulse treatment on the RIC-induced perfusion parameters...
September 30, 2018: Pain Practice: the Official Journal of World Institute of Pain
Dinos Verouhis, Nawzad Saleh, Magnus Settergren, Peder Sörensson, Andrey Gourine, John Pernow
BACKGROUND: Remote ischemic conditioning (RIC), i.e. short cycles of ischemia and reperfusion in remote tissue, is a novel approach to protect against myocardial ischemia-reperfusion injury in ST-elevation myocardial infarction. The nature of the factors transmitting the protective effect of RIC remains unknown, and both neuronal and hormonal mechanisms appear to be involved. A recent study indicated involvement of glucagon-like peptide-1 (GLP-1) regulated by the vagal nerve in RIC in rats...
September 22, 2018: International Journal of Cardiology
Chang-Cheng Zhou, Yu-Zheng Ge, Wen-Tao Yao, Ran Wu, Hui Xin, Tian-Ze Lu, Ming-Hao Li, Kai-Wei Song, Min Wang, Yun-Peng Zhu, Meng Zhu, Li-Guo Geng, Xiao-Fei Gao, Liu-Hua Zhou, Sheng-Li Zhang, Jia-Geng Zhu, Rui-Peng Jia
[This corrects the article DOI: 10.1371/journal.pone.0170729.].
2018: PloS One
A Phillip Owens, Nathan Robbins, Keith Saum, Shannon M Jones, Akiva W Kirschner, Dr Jessica G Woo, Connie McCoy, Samuel Slone, Marc E Rothenberg, Elaine M Urbina, Michael Tranter, Jack Rubinstein
OBJECTIVES: This study assessed whether tefillin use (tight, non-occlusive, wrapping of the arm) elicits a remote ischemic preconditioning (RIPC) like effect in subjects with both acute and chronic use. BACKGROUND: RIPC, created by short bursts of ischemia/reperfusion, has not been successfully taken to the bedside. Several large population studies have found that Orthodox Jewish males (who wear tefillin almost daily) have decreased cardiovascular mortality compared to non-Orthodox counterparts...
September 14, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Dusit Adstamongkonkul, David C Hess
Hypoxic Ischemic Encephalopathy (HIE) is the result of severe anoxic brain injury during the neonatal period and causes life-long morbidity and premature mortality. Currently, therapeutic hypothermia immediately after birth is the standard of care for clinically relevant HIE. However, therapeutic hypothermia alone does not provide complete neuroprotection and there is an urgent need for adjunctive therapies. Ischemic conditioning is an adaptive process of endogenous protection in which small doses of sub-lethal ischemia can provide a protection against a lethal ischemic event...
December 2017: Conditioning medicine
Kumar Vaibhav, Molly Braun, Mohammad Badruzzaman Khan, Sumbul Fatima, Nancy Saad, Adarsh Shankar, Zenab T Khan, Ruth B S Harris, Qiuhua Yang, Yuqing Huo, Ali S Arbab, Shailendra Giri, Cargill H Alleyne, John R Vender, David C Hess, Babak Baban, Md Nasrul Hoda, Krishnan M Dhandapani
Spontaneous intracerebral hemorrhage (ICH) produces the highest acute mortality and worst outcomes of all stroke subtypes. Hematoma volume is an independent determinant of ICH patient outcomes, making clot resolution a primary goal of clinical management. Herein, remote-limb ischemic post-conditioning (RIC), the repetitive inflation-deflation of a blood pressure cuff on a limb, accelerated hematoma resolution and improved neurological outcomes after ICH in mice. Parabiosis studies revealed RIC accelerated clot resolution via a humoral-mediated mechanism...
October 1, 2018: Journal of Experimental Medicine
Puneet Kaur Randhawa, Anjana Bali, Jasleen Kaur Virdi, Amteshwar Singh Jaggi
The aging process induces a plethora of changes in the body including alterations in hormonal regulation and metabolism in various organs including the heart. Aging is associated with marked increase in the vulnerability of the heart to ischemia-reperfusion injury. Furthermore, it significantly hampers the development of adaptive response to various forms of conditioning stimuli (pre/post/remote conditioning). Aging significantly impairs the activation of signaling pathways that mediate preconditioning-induced cardioprotection...
September 2018: Korean Journal of Physiology & Pharmacology
Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Yuan Wang, Xunming Ji, Ran Meng
Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI) encountered, particularly amongst elderly patients with clinical scenarios, such as age-related arteriosclerotic vascular disease, heart surgery and organ transplantation, is still an unsettled conundrum that besets clinicians. Remote ischemic conditioning (RIC), delivered via transient, repetitive noninvasive IR interventions to distant organs or tissues, is regarded as an innovative approach against IRI. Based on the available evidence, RIC holds the potential of affording protection to multiple organs or tissues, which include not only the heart and brain, but also others that are likely susceptible to IRI, such as the kidney, lung, liver and skin...
August 16, 2018: Aging
Yun-Xia Qian, Ke-Sheng Dai, Li-Li Zhao, Xiang-Jun Yang
The recovery of ischemic myocardium blood perfusion is the main treatment option for acute myocardial infarction (AMI). However, this treatment option has multiple side effects that directly affect the quality of life of the patients. The activation of platelet function plays an important role in the occurrence, development and treatment of AMI. The aim of the present study was to analyze the effects of remote ischemic post-conditioning on platelet activation of AMI patients with primary PCI treatment and clinical prognosis...
August 2018: Experimental and Therapeutic Medicine
Philippe Richard, François Billaut
Elite athletes in varied sports typically combine ergogenic strategies in the hope of enhancing physiological responses and competitive performance, but the scientific evidence for such practices is very scarce. The peculiar characteristics of speed skating contribute to impede blood flow and exacerbate deoxygenation in the lower limbs (especially the right leg). We investigated whether combining preconditioning strategies could modify muscular oxygenation and improve performance in that sport. Using a randomized, single-blind, placebo-controlled, crossover design, seven male elite long-track speed skaters performed on-ice 600-m time trials, preceded by either a combination of preconditioning strategies (COMBO) or a placebo condition (SHAM)...
2018: Frontiers in Physiology
Ellen N Sutter, Anna E Mattlage, Marghuretta D Bland, Kendra M Cherry-Allen, Elinor Harrison, Swati M Surkar, Jeffrey M Gidday, Ling Chen, Tamara Hershey, Jin-Moo Lee, Catherine E Lang
Remote limb ischemic conditioning (RLIC) is a clinically feasible method of promoting tissue protection against subsequent ischemic insult. Recent findings from our lab demonstrated that RLIC robustly enhances motor learning in young, healthy humans. The next step is to determine which individuals would receive maximum benefit from RLIC before applying these findings to clinical rehabilitation populations such as stroke. Numerous factors, such as age, sex, body mass index (BMI), and cardiovascular comorbidities may influence the response...
August 7, 2018: Translational Stroke Research
Abraham I J Gajardo, Lukas Karachon, Pablo Bustamante, Pablo Repullo, Marcelo Llancaqueo, Gina Sánchez, Ramón Rodrigo
Remote ischemic preconditioning (RIPC) is a cardioprotective strategy against myocardial damage by ischemia-reperfusion. Many in-vivo and ex-vivo animal researches have demonstrated that RIPC decreases significantly the ischemia-reperfusion myocardial damage, by up to 58% in isolated rat heart. Cardiac artery bypass graft surgery (CABG) is a clinical model of myocardial ischemia-reperfusion and a clinical potential application to RIPC. However, although RIPC has shown successful results in experimental studies, clinical trials on CABG have failed to demonstrate a benefit of RIPC in humans...
September 2018: Medical Hypotheses
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