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Remote ischemic conditioning

Chang-Cheng Zhou, Yu-Zheng Ge, Wen-Tao Yao, Ran Wu, Hui Xin, Tian-Ze Lu, Ming-Hao Li, Kai-Wei Song, Min Wang, Yun-Peng Zhu, Meng Zhu, Li-Guo Geng, Xiao-Fei Gao, Liu-Hua Zhou, Sheng-Li Zhang, Jia-Geng Zhu, Rui-Peng Jia
[This corrects the article DOI: 10.1371/journal.pone.0170729.].
2018: PloS One
A Phillip Owens, Nathan Robbins, Keith Saum, Shannon M Jones, Akiva W Kirschner, Dr Jessica G Woo, Connie McCoy, Samuel Slone, Marc E Rothenberg, Elaine M Urbina, Michael Tranter, Jack Rubinstein
OBJECTIVES: This study assessed whether tefillin use (tight, non-occlusive, wrapping of the arm) elicits a remote ischemic preconditioning (RIPC) like effect in subjects with both acute and chronic use. BACKGROUND: RIPC, created by short bursts of ischemia/reperfusion, has not been successfully taken to the bedside. Several large population studies have found that Orthodox Jewish males (who wear tefillin almost daily) have decreased cardiovascular mortality compared to non-Orthodox counterparts...
September 14, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Dusit Adstamongkonkul, David C Hess
Hypoxic Ischemic Encephalopathy (HIE) is the result of severe anoxic brain injury during the neonatal period and causes life-long morbidity and premature mortality. Currently, therapeutic hypothermia immediately after birth is the standard of care for clinically relevant HIE. However, therapeutic hypothermia alone does not provide complete neuroprotection and there is an urgent need for adjunctive therapies. Ischemic conditioning is an adaptive process of endogenous protection in which small doses of sub-lethal ischemia can provide a protection against a lethal ischemic event...
December 2017: Conditioning medicine
Kumar Vaibhav, Molly Braun, Mohammad Badruzzaman Khan, Sumbul Fatima, Nancy Saad, Adarsh Shankar, Zenab T Khan, Ruth B S Harris, Qiuhua Yang, Yuqing Huo, Ali S Arbab, Shailendra Giri, Cargill H Alleyne, John R Vender, David C Hess, Babak Baban, Md Nasrul Hoda, Krishnan M Dhandapani
Spontaneous intracerebral hemorrhage (ICH) produces the highest acute mortality and worst outcomes of all stroke subtypes. Hematoma volume is an independent determinant of ICH patient outcomes, making clot resolution a primary goal of clinical management. Herein, remote-limb ischemic post-conditioning (RIC), the repetitive inflation-deflation of a blood pressure cuff on a limb, accelerated hematoma resolution and improved neurological outcomes after ICH in mice. Parabiosis studies revealed RIC accelerated clot resolution via a humoral-mediated mechanism...
September 6, 2018: Journal of Experimental Medicine
Puneet Kaur Randhawa, Anjana Bali, Jasleen Kaur Virdi, Amteshwar Singh Jaggi
The aging process induces a plethora of changes in the body including alterations in hormonal regulation and metabolism in various organs including the heart. Aging is associated with marked increase in the vulnerability of the heart to ischemia-reperfusion injury. Furthermore, it significantly hampers the development of adaptive response to various forms of conditioning stimuli (pre/post/remote conditioning). Aging significantly impairs the activation of signaling pathways that mediate preconditioning-induced cardioprotection...
September 2018: Korean Journal of Physiology & Pharmacology
Da Zhou, Jiayue Ding, Jingyuan Ya, Liqun Pan, Yuan Wang, Xunming Ji, Ran Meng
Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI) encountered, particularly amongst elderly patients with clinical scenarios, such as age-related arteriosclerotic vascular disease, heart surgery and organ transplantation, is still an unsettled conundrum that besets clinicians. Remote ischemic conditioning (RIC), delivered via transient, repetitive noninvasive IR interventions to distant organs or tissues, is regarded as an innovative approach against IRI. Based on the available evidence, RIC holds the potential of affording protection to multiple organs or tissues, which include not only the heart and brain, but also others that are likely susceptible to IRI, such as the kidney, lung, liver and skin...
August 16, 2018: Aging
Yun-Xia Qian, Ke-Sheng Dai, Li-Li Zhao, Xiang-Jun Yang
The recovery of ischemic myocardium blood perfusion is the main treatment option for acute myocardial infarction (AMI). However, this treatment option has multiple side effects that directly affect the quality of life of the patients. The activation of platelet function plays an important role in the occurrence, development and treatment of AMI. The aim of the present study was to analyze the effects of remote ischemic post-conditioning on platelet activation of AMI patients with primary PCI treatment and clinical prognosis...
August 2018: Experimental and Therapeutic Medicine
Philippe Richard, François Billaut
Elite athletes in varied sports typically combine ergogenic strategies in the hope of enhancing physiological responses and competitive performance, but the scientific evidence for such practices is very scarce. The peculiar characteristics of speed skating contribute to impede blood flow and exacerbate deoxygenation in the lower limbs (especially the right leg). We investigated whether combining preconditioning strategies could modify muscular oxygenation and improve performance in that sport. Using a randomized, single-blind, placebo-controlled, crossover design, seven male elite long-track speed skaters performed on-ice 600-m time trials, preceded by either a combination of preconditioning strategies (COMBO) or a placebo condition (SHAM)...
2018: Frontiers in Physiology
Ellen N Sutter, Anna E Mattlage, Marghuretta D Bland, Kendra M Cherry-Allen, Elinor Harrison, Swati M Surkar, Jeffrey M Gidday, Ling Chen, Tamara Hershey, Jin-Moo Lee, Catherine E Lang
Remote limb ischemic conditioning (RLIC) is a clinically feasible method of promoting tissue protection against subsequent ischemic insult. Recent findings from our lab demonstrated that RLIC robustly enhances motor learning in young, healthy humans. The next step is to determine which individuals would receive maximum benefit from RLIC before applying these findings to clinical rehabilitation populations such as stroke. Numerous factors, such as age, sex, body mass index (BMI), and cardiovascular comorbidities may influence the response...
August 7, 2018: Translational Stroke Research
Abraham I J Gajardo, Lukas Karachon, Pablo Bustamante, Pablo Repullo, Marcelo Llancaqueo, Gina Sánchez, Ramón Rodrigo
Remote ischemic preconditioning (RIPC) is a cardioprotective strategy against myocardial damage by ischemia-reperfusion. Many in-vivo and ex-vivo animal researches have demonstrated that RIPC decreases significantly the ischemia-reperfusion myocardial damage, by up to 58% in isolated rat heart. Cardiac artery bypass graft surgery (CABG) is a clinical model of myocardial ischemia-reperfusion and a clinical potential application to RIPC. However, although RIPC has shown successful results in experimental studies, clinical trials on CABG have failed to demonstrate a benefit of RIPC in humans...
September 2018: Medical Hypotheses
Yingli Wang, Zhaohui Zhang, Lei Zhang, Haoran Yang, Zhiqiang Shen
OBJECTIVE: Remote limb ischemic post-conditioning (RLIPostC) has been shown to be neuroprotective in cerebral ischemia, whereas the effect of RLIPostC on synaptogenesis remains elusive. In the present study, we investigated the effects of RLIPostC on synaptogenesis in an experimental stroke rat model. METHODS: Sprague-Dawley rats were subjected to left middle cerebral artery occlusion (MCAO) and were randomly divided into a control group, an RLIPostC group and a sham group...
July 23, 2018: Brain Injury: [BI]
Jayasree Nair, Vasantha H S Kumar
Neonatal hypoxic ischemic encephalopathy (HIE) presents a significant clinical burden with its high mortality and morbidity rates globally. Therapeutic hypothermia (TH) is now standard of care for infants with moderate to severe HIE, but has not definitively changed outcomes in severe HIE. In this review, we discuss newer promising markers that may help the clinician identify severity of HIE. Therapies that are beneficial and agents that hold promise for neuroprotection are described, both for use either alone or as adjuncts to TH...
July 19, 2018: Children
Wenbo Zhao, Ruiwen Che, Sijie Li, Changhong Ren, Chuanhui Li, Chuanjie Wu, Hui Lu, Jian Chen, Jiangang Duan, Ran Meng, Xunming Ji
Objective: Remote ischemic conditioning (RIC) has been demonstrated to be safe and feasible for patients with acute ischemic stroke (AIS), as well as for those receiving intravenous thrombolysis. We assessed the safety and feasibility of RIC for AIS patients undergoing endovascular treatment (ET). Methods: We conducted a pilot study with patients with AIS who were suspected of having an emergent large-vessel occlusion in the anterior circulation and who were scheduled for ET within 6 hours of ictus...
July 2018: Annals of Clinical and Translational Neurology
Kerstin Boengler, Günter Lochnit, Rainer Schulz
Several interventions such as ischemic preconditioning, remote pre-/perconditioning, or postconditioning are known to decrease lethal myocardial ischemia/reperfusion injury. Whereas several signal transduction pathways become activated by such maneuvers, they all have a common endpoint, namely the mitochondria. The organelles represent an essential target of the cardioprotective strategies and the preservation of mitochondrial function is central for the reduction of ischemia/reperfusion injury. In the present review we address the role of mitochondria in the different conditioning strategies; in particular, we will focus on alterations of mitochondrial function in terms of energy production, formation of reactive oxygen species, opening of the mitochondrial permeability transition pore, and mitochondrial dynamics induced by ischemia/reperfusion...
July 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Firouzeh Gholampour, Leila Khangah, Jafar Vatanparast, Hamid Reza Karbalaei-Heidari, Seyed Mohammad Owji, Aminollah Bahaoddini
Objectives: We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and Methods: I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was performed using four cycles of 2 min occlusions of the left femoral artery and 3 min reperfusion at the beginning of renal ischemia. The animals were given normal saline (vehicle), NG-nitro-L-arginine methyl ester (L-NAME) or L-arginine...
June 2018: Iranian Journal of Basic Medical Sciences
Jens Rothenberger
BACKGROUND: Improvement of skin microcirculation would be beneficial in transplanted tissues and thus, there is a demand for effective, reliable and harmless angiogenic treatments. The aim of this study was to assess the effect of capsaicin application (CA), the remote effect of capsaicin application (REC), the impact of remote ischemic conditioning (RIC), and the impact of combined remote ischemic conditioning with capsaicin application (Comb) on human skin microcirculation. METHODS: Perfusion changes were assessed using a laser Doppler device (easyLDI, Aimago Lausanne)...
June 9, 2018: Clinical Hemorheology and Microcirculation
Jeffrey C Cowley, Deanna H Gates
During fatiguing tasks, people adapt their movement strategies to offset effects of muscle fatigue. Painful stimuli may compete for cognitive resources during this process, impairing fatigue adaptation. This study determined how pain affected movement control and muscle endurance during a repetitive task and how pain catastrophizing moderated these effects. Twenty-two healthy young adults performed timed reaching movements until voluntary exhaustion on two separate days. On 1 day, subjects simultaneously experienced ischemic pain in the contralateral arm...
August 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Geng Zhou, Ming Hua Li, Gabriel Tudor, Hai Tao Lu, Ramanathan Kadirvel, David Kallmes
Cerebral ischemia and stroke are increasing in prevalence and are among the leading causes of morbidity and mortality in both developed and developing countries. Despite the progress in endovascular treatment, ischemia/reperfusion (IR) injury is an important contributor to post-surgical mortality and morbidity affecting a wide range of neurointerventional procedures. However, pharmacological recruitment of effective cerebral protective signaling has been largely disappointing to date. In remote ischemic conditioning (RIC), repetitive transient mechanical obstruction of vessels at a limb remote from the IR injury site protects vital organs from IR injury and confers infarction size reduction following prolonged arterial occlusion...
2018: Frontiers in Neurology
Vianney Behaghel, Sophie Tamareille, Marion Rabant, Delphine Mirebeau-Prunier, Loïc Bière, Laurent Macchi, Fabrice Prunier
Ischemia-reperfusion (I/R) injury is a leading cause of acute renal dysfunction. Remote ischemic conditioning (rIC) is known to protect organs exposed to I/R. We sought to investigate whether rIC would influence renal function recovery in a severe renal I/R injury rat model. Rats were randomly assigned to four experimental groups following median laparotomy and right nephrectomy: Sham (n = 6); 30-min left renal ischemia (RI) only (n = 20); RI+rIC (n = 20) (four 5-min cycles of limb ischemia interspersed with 5-min limb reperfusion during RI); RI+erythropoietin pre-treatment (EPO) (n = 20)...
May 24, 2018: Shock
John H Rosenberg, John H Werner, Michael J Moulton, Devendra K Agrawal
Ischemic preconditioning is a process which serves to mitigate reperfusion injury. Preconditioning of the heart can be achieved through natural, pharmacological, and mechanical means. Mechanical preconditioning appears to have the greatest chance of good outcomes while methods employing pharmacologic preconditioning have been largely unsuccessful. Remote ischemic preconditioning achieves a cardioprotective effect by applying cycles of ischemia and reperfusion in a distal limb, stimulating the release of a neurohumoral cardioprotective factor incited by stimulation of afferent neurons...
August 2018: Journal of Cardiovascular Translational Research
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