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Remote ischemic conditioning

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https://www.readbyqxmd.com/read/29768493/remote-ischemic-preconditioning-stat3-dependently-ameliorates-pulmonary-ischemia-reperfusion-injury
#1
Nanfu Luo, Jin Liu, Yan Chen, Huan Li, Zhaoyang Hu, Geoffrey W Abbott
The lungs are highly susceptible to injury, including ischemia/reperfusion (I/R) injury. Pulmonary I/R injury can occur when correcting conditions such as primary pulmonary hypertension, and is also relatively common after lung transplantation or other cardiothoracic surgery. Methods to reduce pulmonary I/R injury are urgently needed to improve outcomes following procedures such as lung transplantation. Remote liver ischemic preconditioning (RLIPC) is an effective cardioprotective measure, reducing damage caused by subsequent cardiac I/R injury, but little is known about its potential role in pulmonary protection...
2018: PloS One
https://www.readbyqxmd.com/read/29740345/conduit-artery-diameter-during-exercise-is-enhanced-after-local-but-not-remote-ischemic-preconditioning
#2
Scott Cocking, N T Cable, Mathew G Wilson, Daniel J Green, Dick H J Thijssen, Helen Jones
Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise. Methods: Eighteen healthy, recreationally trained, male participants (mean ± SD : age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1 ) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29726013/effect-of-comprehensive-remote-ischemic-conditioning-in-anterior-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-design-and-rationale-of-the-coric-mi-randomized-trial
#3
Li Song, Hongbing Yan, Peng Zhou, Hanjun Zhao, Chen Liu, Zhaoxue Sheng, Yu Tan, Yi Chen, Jiannan Li, Jinying Zhou
BACKGROUND: Remote ischemic conditioning (RIC) applied during or after an ST-segment elevation myocardial infarction (STEMI) is currently the most promising adjuvant therapy to reduce reperfusion injury. Recent animal studies showed that RIC may help the myocardium recover if applied daily during the month after an STEMI. METHODS: The CORIC-MI trial is a single-center, randomized controlled study. 200 patients undergoing primary percutaneous coronary intervention (PPCI) for anterior STEMI will be randomized in a 1:1 ratio into comprehensive RIC (CORIC) or no intervention (control)...
May 3, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29722251/effects-of-local-versus-remote-ischemic-preconditioning-on-repeated-sprint-running-performance
#4
Patrick J Griffin, Luke Hughes, Conor Gissane, Stephen D Patterson
BACKGROUND: The aim of this study was to compare the effect of local and remote ischemic preconditioning (IPC) on repeated sprint exercise. METHODS: Twelve males (age 22 ± 2 years; stature 1.79±0.07 m; body mass 77.8±8.4 kg; mean ± SD) completed four trials consisting of remote (arm) and local (leg) IPC and SHAM interventions prior to repeated sprint exercise (3 x (6 x 15 + 15-m) shuttle sprints), in a double-blind, randomised, crossover designed study. These tests were immediately preceded by IPC (4 x 5 minute intervals at 220 mmHg bilateral occlusion) or SHAM treatment (4 x 5 minute intervals at 20 mmHg bilateral occlusion)...
May 2, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29719445/mechanisms-involved-in-adenosine-pharmacological-preconditioning-induced-cardioprotection
#5
REVIEW
Lovedeep Singh, Ritu Kulshrestha, Nirmal Singh, Amteshwar Singh Jaggi
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury...
May 2018: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29660911/the-effects-of-different-remote-ischemic-conditioning-on-ischemia-induced-failure-of-microvascular-circulation-in-humans
#6
Muzaffer Akkoca, Suzan Emel Usanmaz, Serhat Tokgöz, Cüneyt Köksoy, Emine Demirel-Yilmaz
BACKGROUND: Intermittent ischemia in remote tissues can be applied before ischemic injury, during ischemic injury or at the beginning of reperfusion of an index organ ischemia. The aim of this study was to investigate the effect of Remote Ischemic Conditioning (RIC) of the leg on changes in ischemia-induced the microvascular functions of the arm. MATERIAL AND METHODS: Ischemic microvascular injury was induced by arm ischemia (20 min) and reperfusion in healthy, nonsmoker, male volunteers (ischemia group-ISC, n: 9)...
April 13, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29617450/limb-remote-ischemic-conditioning-of-the-recipient-protects-the-liver-in-a-rat-model-of-arterialized-orthotopic-liver-transplantation
#7
Zoltan Czigany, Christian Bleilevens, Christian Beckers, Christian Stoppe, Michaela Möhring, Andras Fülöp, Attila Szijarto, Georg Lurje, Ulf P Neumann, René H Tolba
BACKGROUND: Ischemic-reperfusion (IR) injury still represents a major concern in clinical transplantation, especially in the era of extreme organ shortage and extended criteria donor organs. In the present study we aimed to investigate the hepatoprotective effects of remote ischemic conditioning (RIC) in a rat model of arterialized orthotopic liver transplantation (OLT). METHODS: Male Lewis rats were used (n = 144 / 72 OLT cases; 240-340g) as donors and recipients...
2018: PloS One
https://www.readbyqxmd.com/read/29600029/lung-protection-in-patients-undergoing-pulmonary-lobectomy-a-new-perspective-for-remote-ischemic-conditioning-in-surgery
#8
EDITORIAL
Fabrice Prunier, Delphine Mirebeau-Prunier
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29569958/influence-of-long-term-treatment-with-glyceryl-trinitrate-on-remote-ischemic-conditioning
#9
Marie Hauerslev, Sivagowry Rasalingam Mørk, Kasper Pryds, Hussain Contractor, Jan Hansen, Nichlas Riise Jespersen, Jacob Johnsen, Gerd Heusch, Petra Kleinbongard, Rajesh Kharbanda, Hans Erik Bøtker, Michael Rahbek Schmidt
Remote ischemic conditioning (RIC) protects against sustained myocardial ischemia. Due to overlapping mechanisms this protection may be altered by glyceryl trinitrate (GTN), which is commonly used in the treatment of patients with chronic ischemic heart disease. We investigated whether long-term GTN treatment modifies the protection by RIC in rat myocardium and human endothelium. We studied infarct size (IS) in rat hearts subjected to global ischemia-reperfusion (I/R) in vitro and endothelial function in healthy volunteers subjected to I/R of the upper arm...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29531045/complex-electrophysiological-remodeling-in-postinfarction-ischemic-heart-failure
#10
Bence Hegyi, Julie Bossuyt, Leigh G Griffiths, Rafael Shimkunas, Zana Coulibaly, Zhong Jian, Kristin N Grimsrud, Claus S Sondergaard, Kenneth S Ginsburg, Nipavan Chiamvimonvat, Luiz Belardinelli, András Varró, Julius G Papp, Piero Pollesello, Jouko Levijoki, Leighton T Izu, W Douglas Boyd, Tamás Bányász, Donald M Bers, Ye Chen-Izu
Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires detailed understanding of electrophysiological remodeling. However, changes of ionic currents in ischemic HF remain incompletely understood, especially in translational large-animal models. Here, we systematically measure the major ionic currents in ventricular myocytes from the infarct border and remote zones in a porcine model of post-MI HF. We recorded eight ionic currents during the cell's action potential (AP) under physiologically relevant conditions using self AP-clamp sequential dissection...
March 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29516255/25-years-of-remote-ischemic-conditioning-from-laboratory-curiosity-to-clinical-outcome
#11
EDITORIAL
Gerd Heusch
No abstract text is available yet for this article.
March 7, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29506711/euro-crips-another-piece-of-evidence-for-systemic-cardiovascular-protection-by-remote-ischemic-conditioning
#12
EDITORIAL
Gerd Heusch
No abstract text is available yet for this article.
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29498531/clinical-translation-of-myocardial-conditioning
#13
Hans Erik Botker, Thomas Ravn Lassen, Nichlas Riise Jespersen
Rapid admission and acute interventional treatment combined with modern antithrombotic pharmacologic therapy have improved outcome in patients with ST-elevation myocardial infarction. The next major target to further improve outcome, seems to be ischemia reperfusion injury, which may contribute significantly to the final infarct size and hence mortality and post-infarction heart failure. Mechanical conditioning strategies including local and remote ischemic pre-, per- and postconditioning have demonstrated consistent cardioprotective capacities in experimental models of acute IR injury...
March 2, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29492224/remote-ischemic-conditioning-improves-myocardial-parameters-and-clinical-outcomes-during-primary-percutaneous-coronary-intervention-a-meta-analysis-of-randomized-controlled-trials
#14
Hai Liu, Li Fu, Xiangke Sun, Wei Peng, Zhiwei Chen, Yiliang Li
We conducted a systematic review and meta-analysis to evaluate the effects of remote ischemic conditioning on myocardial parameters and clinical outcomes in ST segment elevation acute myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention. Ten eligible randomized controlled trials with 1006 STEMI patients were identified. Compared with controls, remote ischemic conditioning reduced the myocardial enzyme levels (standardized mean difference =-0.86; 95% CI: -1.44 to -0.28; P = 0...
February 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467715/limb-remote-ischemic-conditioning-mechanisms-anesthetics-and-the-potential-for-expanding-therapeutic-options
#15
REVIEW
Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Sylvain Doré
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29467197/reflection-of-cardioprotection-by-remote-ischemic-perconditioning-in-attenuated-st-segment-elevation-during-ongoing-coronary-occlusion-in-pigs-evidence-for-cardioprotection-from-ischemic-injury
#16
Petra Kleinbongard, Georgios Amanakis, Andreas Skyschally, Gerd Heusch
RATIONALE: Reduction of infarct size by remote ischemic perconditioning (perRIC) is evident only after several hours reperfusion. OBJECTIVE: To develop a potential real-time estimate of cardioprotection by perRIC, we have analyzed the time course of ST-segment elevation. METHODS AND RESULTS: Anesthetized open-chest pigs were subjected to 60-minute coronary occlusion and 180-minute reperfusion (placebo; n=19). PerRIC (n=18; 4×5 min/5 min hindlimb occlusion/reperfusion) was induced 20 minutes after coronary occlusion...
April 13, 2018: Circulation Research
https://www.readbyqxmd.com/read/29462606/limb-remote-ischemic-post-conditioning-mitigates-brain-recovery-in-a-mouse-model-of-ischemic-stroke-by-regulating-reactive-astrocytic-plasticity
#17
Xue Cheng, Haiping Zhao, Feng Yan, Zhen Tao, Rongliang Wang, Ziping Han, Guangwen Li, Yumin Luo, Xunming Ji
Maladaptive alterations of astrocytic plasticity may cause brain edema in the acute stage of stroke and glial scar formation in the recovery stage. The present study was designed to investigate the potential regulation of limb remote ischemic post-conditioning (RIPC) on astrocytic plasticity in experimental cerebral ischemia-reperfusion injury. Cerebral ischemia was induced by transient middle cerebral artery occlusion (tMCAO) for 1 h in C57BL/6 mice, who were treated with RIPC immediately after reperfusion...
May 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29443855/continuous-remote-ischemic-conditioning-attenuates-cognitive-and-motor-deficits-from-moderate-traumatic-brain-injury
#18
Viraj Pandit, Muhammad Khan, El Rasheid Zakaria, Tally M Largent-Milnes, Mohammad Hamidi, Terence O'Keeffe, Todd W Vanderah, Bellal Joseph
INTRODUCTION: While studies show that single-dose remote ischemic conditioning (RIC) improves outcomes, the effect of continuous (daily) RIC is unknown. Thus, we aimed to investigate the role of continuous-RIC on cognitive and motor function following traumatic brain injury (TBI). METHODS: We subjected 24 male C57BL mice to a cortical-controlled TBI. Two-hours after TBI the animals were randomly allocated to the RIC group (n=12) or the Sham group (n=12). RIC was induced by non-invasive external compression of the hind limb using an occlusive band (six 4-min cycles/24 hours) for consecutive 6 days...
February 14, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29417868/non-coding-rnas-as-therapeutic-targets-for-preventing-myocardial-ischemia-reperfusion-injury
#19
Sang-Bing Ong, Khairunnisa Katwadi, Xiu-Yi Kwek, Nur Izzah Ismail, Kroekkiat Chinda, Sang-Ging Ong, Derek J Hausenloy
New treatments are required to improve clinical outcomes in patients with acute myocardial infarction (AMI), for reduction of myocardial infarct (MI) size and preventing heart failure. Following AMI, acute ischemia/reperfusion injury (IRI) ensues, resulting in cardiomyocyte death and impaired cardiac function. Emerging studies have implicated a fundamental role for non-coding RNAs (microRNAs [miRNA], and more recently long non-coding RNAs [lncRNA]) in the setting of acute myocardial IRI. Areas covered: In this article, we discuss the roles of miRNAs and lncRNAs as potential biomarkers and therapeutic targets for the detection and treatment of AMI, review their roles as mediators and effectors of cardioprotection, particularly in the settings of interventions such as ischemic pre- and post-conditioning (IPC & IPost) as well as remote ischemic conditioning (RIC), and highlight future strategies for targeting ncRNAs to reduce MI size and prevent heart failure following AMI...
March 2018: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29399973/remote-limb-ischemic-postconditioning-promotes-motor-function-recovery-in-a-rat-model-of-ischemic-stroke-via-the-up-regulation-of-endogenous-tissue-kallikrein
#20
Dan Liang, Xi-Biao He, Zheng Wang, Ce Li, Bei-Yao Gao, Jun-Fa Wu, Yu-Long Bai
AIMS: Remote ischemic conditionings, such as pre- and per-conditioning, are known to provide cardioprotection in animal models of ischemia. However, little is known about the neuroprotection effect of postconditioning after cerebral ischemia. In this study, we aim to evaluate the motor function rescuing effect of remote limb ischemic postconditioning (RIPostC) in a rat model of acute cerebral stroke. METHODS: Left middle cerebral artery occlusion (MCAO) was performed to generate the rat model of ischemic stroke, followed by daily RIPostC treatment for maximum 21 days...
February 4, 2018: CNS Neuroscience & Therapeutics
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