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Remote ischemic conditioning

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https://www.readbyqxmd.com/read/28535981/protective-effect-of-remote-limb-post-conditioning-via-upregulation-of-heme-oxygenase-1-bdnf-pathway-in-rat-model-of-cerebral-ischemic-reperfusion-injury
#1
Sruthi Ramagiri, Rajeev Taliyan
AIM: Remote ischemic Post Conditioning (RIPOC) has shown to be neuroprotective against cerebral Ischemic Reperfusion (I/R) injury. However, the RIPOC protection against I/R injury induced cognitive abnormalities still remains elusive. Abundant evidence from earlier studies highlighted the role of heme oxygenase-1 (HO-1) in neuronal survival in various neurodegenerative disorders. Thus, in the present study, we investigated the possible contribution of HO-1 in RIPOC mediated neuroprotection against cerebral I/R injury and associated cognitive deficits...
May 20, 2017: Brain Research
https://www.readbyqxmd.com/read/28515120/remote-ischemic-perconditioning-to-reduce-reperfusion-injury-during-acute-st-segment-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis
#2
REVIEW
Shelley L McLeod, Alla Iansavichene, Sheldon Cheskes
BACKGROUND: Remote ischemic conditioning (RIC) is a noninvasive therapeutic strategy that uses brief cycles of blood pressure cuff inflation and deflation to protect the myocardium against ischemia-reperfusion injury. The objective of this systematic review was to determine the impact of RIC on myocardial salvage index, infarct size, and major adverse cardiovascular events when initiated before catheterization. METHODS AND RESULTS: Electronic searches of Medline, Embase, and Cochrane Central Register of Controlled Trials were conducted and reference lists were hand searched...
May 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28513214/the-future-of-remote-ischemic-conditioning
#3
Karin Przyklenk, Peter Whittaker
No abstract text is available yet for this article.
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28513213/remote-ischemic-conditioning-the-commercial-market-cellaegis-perspective
#4
Vera Belaoussoff, Rocky Ganske, Andrew Redington
Remote ischemic conditioning (RIC) is at a pivotal point in its evolution, both in terms of its adoption as a therapy and its viability commercially. The most usual way of inducing RIC, with a standard blood pressure cuff and a stopwatch, is time-consuming and potentially inaccurate and unsafe. Development of automated devices have facilitated large-scale randomized trials and will make clinical deployment of the technique more straightforward. Both the medical and commercial future of RIC will depend on the results of upcoming phase 3 pivotal trials...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28482626/ten-minutes-of-ischemia-is-superior-to-shorter-intervals-for-the-remote-ischemic-conditioning-of-human-microcirculation
#5
J Kolbenschlag, A Sogorski, C Timmermann, K Harati, A Daigeler, T Hirsch, O Goertz, M Lehnhardt
BACKGROUND: Surgical flaps have become reliable tools in the microsurgical armamentarium, but are still faced with tissue loss due to impaired perfusion which can lead to complete flap failure. Remote Ischemic Conditioning (RIC) has been demonstrated to be an effective way to improve microcirculation in surgical flaps in humans. However, little is known about the optimal amount and length of RIC cycles. OBJECTIVE: Determination of a superior protocol for RIC of cutaneous microcirculation in humans...
May 5, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28479248/effects-of-non-invasive-remote-ischemic-conditioning-on-rehabilitation-after-myocardial-infarction
#6
Meng-Yao An, Yan Li, Wen-Hua Chen, Ying Zhang, Yan-Na Wu, Kai Sun, Ying-Ying Pan, Yong-Qiang Yin, Jian-Shi Lou
Recent studies have demonstrated that remote ischemic conditioning (RIC) creates cardioprotection against ischemia/reperfusion injury and myocardial infarction (MI); however, the effects of non-invasive remote ischemic conditioning (nRIC) on prognosis and rehabilitation after MI (post-MI) remain unknown. We successfully established MI models involving healthy adult male Sprague-Dawley rats. The nRIC group repeatedly underwent 5 min of ischemia and 5 min of reperfusion in the left hind limb for three cycles every other day until weeks 4, 6, and 8 after MI...
May 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28473744/untargeted-metabolomics-reveals-a-mild-impact-of-remote-ischemic-conditioning-on-the-plasma-metabolome-and-%C3%AE-hydroxybutyrate-as-a-possible-cardioprotective-factor-and-biomarker-of-tissue-ischemia
#7
Mia Roest Laursen, Jakob Hansen, Casper Elkjær, Ninna Stavnager, Camilla Bak Nielsen, Kasper Pryds, Jacob Johnsen, Jan Møller Nielsen, Hans Erik Bøtker, Mogens Johannsen
INTRODUCTION: Remote ischemic conditioning (RIC) is a maneuver by which short non-lethal ischemic events are applied on distant organs or limbs to reduce ischemia and reperfusion injuries caused by e.g. myocardial infarct. Although intensively investigated, the specific mechanism of this protective phenomenon remains incompletely understood and in particular, knowledge on the role of small metabolites is scarce. OBJECTIVES: In this study, we aimed to study perturbations in the plasma metabolome following RIC and gain insight into metabolic changes by the intervention as well as to identify potential novel cardio-protective metabolites...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28454323/microrna-29a-b-c-targets-inos-and-is-involved-in-protective-remote-ischemic-preconditioning-in-an-ischemia-reperfusion-rat-model-of-non-alcoholic-fatty-liver-disease
#8
Yun-Fei Duan, Dong-Lin Sun, Jing Chen, Feng Zhu, Yong An
Remote ischemic preconditioning (RIPC) protects against the injury that is incurred by ischemia and reperfusion (IR); however, the role of RIPC in liver IR injury in non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, a NAFLD rat model was utilized in a series of different surgical procedures and molecular experiments. Rats of the IR group and the RIPC+IR group exhibited more severe injury than NAFLD control rats (in which the liver was prodded following a median-incision laparotomy). The liver condition, measured by serum alanine transaminase and aspartate transaminase levels, of the RIPC+IR group was better than that of the IR group...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28443376/remote-ischemic-conditioning-and-renal-protection
#9
Georgios Giannopoulos, Dimitrios A Vrachatis, Vasiliki Panagopoulou, Manolis Vavuranakis, Michael W Cleman, Spyridon Deftereos
Over the course of the last 2 decades, the concept of remote ischemic conditioning (RIC) has attracted considerable research interest, because RIC, in most of its embodiments offers an inexpensive way of protecting tissues against ischemic damage inflicted by a number of medical conditions or procedures. Acute kidney injury (AKI) is a common side effect in the context of various medical procedures, and RIC has been suggested as a means of reducing its incidence. Outcomes regarding kidney function have been reported in numerous studies that evaluated the effects of RIC in a variety of settings (eg, cardiac surgery, interventions requiring intravenous administration of contrast media)...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28403347/influence-of-remote-ischemic-conditioning-and-tramadol-hydrochloride-on-oxidative-stress-in-kidney-ischemia-reperfusion-injury-in-rats
#10
Rita de Cássia Silva de Oliveira, Marcus Vinicius Henriques Brito, Rubens Fernando Gonçalves Ribeiro, Leonam Oliver Durval Oliveira, Andrew Moraes Monteiro, Fernando Mateus Viegas Brandão, Lainy Carollyne da Costa Cavalcante, Eduardo Henrique Herbster Gouveia, Higor Yuri Bezerra Henriques
Purpose: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28401075/repeated-remote-ischemic-conditioning-effect-on-ankle-brachial-index-in-diabetic-patients-a-randomized-control-trial
#11
Najmeh Shahvazian, Mansour Rafiee, Masoud Rahmanian, Seyed Kazem Razavi-Ratki, Mohammad Hadi Farahzadi
BACKGROUND: Remote ischemic preconditioning (RIPC) is a phenomenon where a short period of ischemia in one organ protects against further ischemia in the other organs. We hypothesized that RIPC occurring in diabetic patients with ankle brachial index (ABI) between 0.70 and 0.90 were included with peripheral arterial disease, would make the better coronary flow resulted in the increasing ABI. MATERIALS AND METHODS: This randomized clinical trial study was done in the Afshar Cardiovascular Hospital in Yazd between 2013 and 2014...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28391169/hypoxia-induced-extracellular-vesicles-mediate-protection-of-remote-ischemic-preconditioning-for-renal-ischemia-reperfusion-injury
#12
Guangyuan Zhang, Yu Yang, Yeqing Huang, Lei Zhang, Zhixin Ling, Yingjian Zhu, Feng Wang, Xiangyu Zou, Ming Chen
Remote ischemic preconditioning (rIPC) is a reliable strategy for prevention of injury to various organs. However the mechanism by which it does so is still unclear. In the present study, serum and EVs isolated from ischemic preconditioned right renal venous perfusates were injected into rats with ischemia-reperfusion-injured kidneys immediately after reperfusion. The animals were killed 24h later. Tubular scores and renal function were tested to evaluate the therapeutic effects. To further explore the underlying mechanism, HK-2 cells derived EVs under hypoxia were also administrated to rats with left kidney IRI...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28381115/remote-ischemic-conditioning-for-patients-with-stemi
#13
Michael Rahbek Schmidt, Mathis Ersted Rasmussen, Hans Erik Bøtker
ST-segment elevation myocardial infarction (STEMI) remains a leading cause of death and morbidity, despite declining incidence and improved short-term outcome in many countries. Although mortality declines in developed countries with easy and fast access to optimized treatment, development of heart failure often remains a challenge in survivors and still approaches 10% at 1 year. Rapid admission and acute interventional treatment combined with modern antithrombotic pharmacologic therapy frequently establish complete reperfusion and acutely stabilize the patient, but the reperfusion itself adds further to the damage in the myocardium compromising the long-term outcome...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28376636/remote-ischemic-conditioning-in-elective-pci
#14
Joel P Giblett, Stephen P Hoole
This review examines the rationale for using remote ischemic conditioning (RIC) in elective percutaneous coronary intervention (PCI) to prevent procedure-related ischemia-reperfusion injury and justifies the importance of periprocedural biomarker elevation following elective PCI as a valid target for RIC. We review the evidence for the use of RIC as a treatment in this setting and document the salutary rules that must be followed to successfully translate RIC for clinical benefit.
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28364777/in-vivo-mri-and-ex-vivo-histological-assessment-of-the-cardioprotection-induced-by-ischemic-preconditioning-postconditioning-and-remote-conditioning-in-a-closed-chest-porcine-model-of-reperfused-acute-myocardial-infarction-importance-of-microvasculature
#15
Tamás Baranyai, Zoltán Giricz, Zoltán V Varga, Gábor Koncsos, Dominika Lukovic, András Makkos, Márta Sárközy, Noémi Pávó, András Jakab, Csilla Czimbalmos, Hajnalka Vágó, Zoltán Ruzsa, Levente Tóth, Rita Garamvölgyi, Béla Merkely, Rainer Schulz, Mariann Gyöngyösi, Péter Ferdinandy
BACKGROUND: Cardioprotective value of ischemic post- (IPostC), remote (RIC) conditioning in acute myocardial infarction (AMI) is unclear in clinical trials. To evaluate cardioprotection, most translational animal studies and clinical trials utilize necrotic tissue referred to the area at risk (AAR) by magnetic resonance imaging (MRI). However, determination of AAR by MRI' may not be accurate, since MRI-indices of microvascular damage, i.e., myocardial edema and microvascular obstruction (MVO), may be affected by cardioprotection independently from myocardial necrosis...
April 1, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28341347/remote-limb-ischemic-post-conditioning-during-early-reperfusion-alleviates-cerebral-ischemic-reperfusion-injury-via-gsk-3%C3%AE-creb-bdnf-pathway
#16
Sruthi Ramagiri, Rajeev Taliyan
Remote limb ischemic post conditioning (RIPOC) has been reported to attenuate cerebral ischemic reperfusion (I/R) injury, while the molecular mechanisms remain elusive. Various studies have highlighted the involvement of glycogen synthase kinase (GSK-3β) in cerebral I/R injury and cognitive disorders. Hence, the present study was designed to explore the role of GSK-3β and its downstream regulators in RIPOC mediated neuroprotection against cerebral I/R injury and associated cognitive impairment. Male Wistar rats are randomly assigned into four groups: Sham, bilateral common carotid arteries occlusion (BCCAO), RIPOC and BCCAO+RIPOC...
May 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28339014/effects-of-remote-ischemic-post%C3%A2-conditioning-on-fracture-healing-in-rats
#17
Meng Zhou, Shibao Lu, Guowei Lu, Jiang Huang, Limin Liu, Shuai An, Zheng Li, Huiliang Shen
Remote ischemic post‑conditioning (RIPC) is an established method to activate the hypoxia‑inducible factor‑1α (HIF‑1α) pathway, which is involved in the impairment of fracture healing. However, the role of RIPC in fracture healing remains to be fully elucidated. In the present study, rats received fractures and were divided into two groups: Control and RIPC, in which hind limb occlusion was performed. Rats were sacrificed at 7, 14, 28 and 42 days subsequent to tibial fracture. Micro‑computed tomography was performed to measure healing of the bone tissue and biomechanical testing was used to test mechanical strength...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28334684/biochemical-signaling-by-remote-ischemic-conditioning-of-the-arm-versus-thigh-is-one-raise-of-the-cuff-enough
#18
Cameron Dezfulian, Maia Taft, Catherine Corey, Gabrielle Hill, Nicholas Krehel, Jon C Rittenberger, Frank X Guyette, Sruti Shiva
Remote Ischemic Conditioning (RIC), induced by brief cycles of ischemia and reperfusion, protects vital organs from a prolonged ischemic insult. While several biochemical mediators have been implicated in RIC's mechanism of action, it remains unclear whether the localization or "dose" of RIC affects the extent of protective signaling. In this randomized crossover study of healthy individuals, we tested whether the number of cycles of RIC and its localization (arm versus thigh) determines biochemical signaling and cytoprotection...
March 18, 2017: Redox Biology
https://www.readbyqxmd.com/read/28284901/the-application-and-neuroprotective-mechanisms-of-cerebral-ischemic-post-conditioning-a-review
#19
REVIEW
Zhixing Li, Hanlin Chen, Jinglei Lv, Renliang Zhao
Ischemic stroke is a serious cerebrovascular disease that leads to death and/or severe disability, and extensive research has been directed in search of appropriate treatment measures. One such potential treatment is the use of cerebral ischemic post-conditioning (IPostC), and its neuroprotective effects and controllability have been widely confirmed and validated. Numerous studies have indicated that cerebral IPostC can suppress the inflammatory reaction in ischemia reperfusion injury, improve cerebral circulation, reduce infarct volume, and promote both neurogenesis and angiogenesis...
March 8, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28280793/human-second-window-pre-conditioning-and-post-conditioning-by-nitrite-is-influenced-by-a-common-polymorphism-in-mitochondrial-aldehyde-dehydrogenase
#20
Julian O M Ormerod, Jonathan D W Evans, Hussain Contractor, Matteo Beretta, Sayqa Arif, Bernadette O Fernandez, Martin Feelisch, Bernd Mayer, Rajesh K Kharbanda, Michael P Frenneaux, Houman Ashrafian
Pre-conditioning is an exciting physiological phenomenon that, despite great efforts, has so far resisted translation to mainstream clinical medicine. Many potential triggers (e.g., ischemia of the organ in question or a remote organ, many different drugs) have been investigated, but recent work has implicated activation of mitochondrial aldehyde dehydrogenase (ALDH2) as central to the process. A genetic polymorphism, known as ALDH2*2, is common worldwide (present in up to 40% of Han Chinese people) and produces a functionally different enzyme...
February 2017: JACC. Basic to Translational Science
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