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Remote ischemic conditioning

Wenbo Zhao, Ruiwen Che, Sijie Li, Changhong Ren, Chuanhui Li, Chuanjie Wu, Hui Lu, Jian Chen, Jiangang Duan, Ran Meng, Xunming Ji
Objective: Remote ischemic conditioning (RIC) has been demonstrated to be safe and feasible for patients with acute ischemic stroke (AIS), as well as for those receiving intravenous thrombolysis. We assessed the safety and feasibility of RIC for AIS patients undergoing endovascular treatment (ET). Methods: We conducted a pilot study with patients with AIS who were suspected of having an emergent large-vessel occlusion in the anterior circulation and who were scheduled for ET within 6 hours of ictus...
July 2018: Annals of Clinical and Translational Neurology
Kerstin Boengler, Günter Lochnit, Rainer Schulz
Several interventions such as ischemic preconditioning, remote pre-/perconditioning, or postconditioning are known to decrease lethal myocardial ischemia/reperfusion injury. Whereas several signal transduction pathways become activated by such maneuvers, they all have a common endpoint, namely the mitochondria. The organelles represent an essential target of the cardioprotective strategies and the preservation of mitochondrial function is central for the reduction of ischemia/reperfusion injury. In the present review we address the role of mitochondria in the different conditioning strategies; in particular, we will focus on alterations of mitochondrial function in terms of energy production, formation of reactive oxygen species, opening of the mitochondrial permeability transition pore, and mitochondrial dynamics induced by ischemia/reperfusion...
July 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Firouzeh Gholampour, Leila Khangah, Jafar Vatanparast, Hamid Reza Karbalaei-Heidari, Seyed Mohammad Owji, Aminollah Bahaoddini
Objectives: We investigated the role of nitric oxide (NO) in the protective effects of remote ischemic per-conditioning (rIPerC) on renal ischemia/reperfusion (I/R) injury in male rats. Materials and Methods: I/R treatment consisted of 45 min bilateral renal artery ischemia and 24 hr reperfusion interval. rIPerC was performed using four cycles of 2 min occlusions of the left femoral artery and 3 min reperfusion at the beginning of renal ischemia. The animals were given normal saline (vehicle), NG-nitro-L-arginine methyl ester (L-NAME) or L-arginine...
June 2018: Iranian Journal of Basic Medical Sciences
Jens Rothenberger
BACKGROUND: Improvement of skin microcirculation would be beneficial in transplanted tissues and thus, there is a demand for effective, reliable and harmless angiogenic treatments. The aim of this study was to assess the effect of capsaicin application (CA), the remote effect of capsaicin application (REC), the impact of remote ischemic conditioning (RIC), and the impact of combined remote ischemic conditioning with capsaicin application (Comb) on human skin microcirculation. METHODS: Perfusion changes were assessed using a laser Doppler device (easyLDI, Aimago Lausanne)...
June 9, 2018: Clinical Hemorheology and Microcirculation
Jeffrey C Cowley, Deanna H Gates
During fatiguing tasks, people adapt their movement strategies to offset effects of muscle fatigue. Painful stimuli may compete for cognitive resources during this process, impairing fatigue adaptation. This study determined how pain affected movement control and muscle endurance during a repetitive task and how pain catastrophizing moderated these effects. Twenty-two healthy young adults performed timed reaching movements until voluntary exhaustion on two separate days. On 1 day, subjects simultaneously experienced ischemic pain in the contralateral arm...
August 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Geng Zhou, Ming Hua Li, Gabriel Tudor, Hai Tao Lu, Ramanathan Kadirvel, David Kallmes
Cerebral ischemia and stroke are increasing in prevalence and are among the leading causes of morbidity and mortality in both developed and developing countries. Despite the progress in endovascular treatment, ischemia/reperfusion (IR) injury is an important contributor to post-surgical mortality and morbidity affecting a wide range of neurointerventional procedures. However, pharmacological recruitment of effective cerebral protective signaling has been largely disappointing to date. In remote ischemic conditioning (RIC), repetitive transient mechanical obstruction of vessels at a limb remote from the IR injury site protects vital organs from IR injury and confers infarction size reduction following prolonged arterial occlusion...
2018: Frontiers in Neurology
Vianney Behaghel, Sophie Tamareille, Marion Rabant, Delphine Mirebeau-Prunier, Loïc Bière, Laurent Macchi, Fabrice Prunier
Ischemia-reperfusion (I/R) injury is a leading cause of acute renal dysfunction. Remote ischemic conditioning (rIC) is known to protect organs exposed to I/R. We sought to investigate whether rIC would influence renal function recovery in a severe renal I/R injury rat model. Rats were randomly assigned to four experimental groups following median laparotomy and right nephrectomy: Sham (n = 6); 30-min left renal ischemia (RI) only (n = 20); RI+rIC (n = 20) (four 5-min cycles of limb ischemia interspersed with 5-min limb reperfusion during RI); RI+erythropoietin pre-treatment (EPO) (n = 20)...
May 24, 2018: Shock
John H Rosenberg, John H Werner, Michael J Moulton, Devendra K Agrawal
Ischemic preconditioning is a process which serves to mitigate reperfusion injury. Preconditioning of the heart can be achieved through natural, pharmacological, and mechanical means. Mechanical preconditioning appears to have the greatest chance of good outcomes while methods employing pharmacologic preconditioning have been largely unsuccessful. Remote ischemic preconditioning achieves a cardioprotective effect by applying cycles of ischemia and reperfusion in a distal limb, stimulating the release of a neurohumoral cardioprotective factor incited by stimulation of afferent neurons...
May 24, 2018: Journal of Cardiovascular Translational Research
Ashish K Rehni, Kunjan R Dave
Diabetes is a serious metabolic disease characterized by hyperglycemia. Diabetes also leads to several long-term secondary complications. Cardiovascular disease is an important complication of diabetes and is a major contributor to morbidity and mortality in diabetic subjects. The discovery of conditioning-induced ischemic or anoxic tolerance has led to the demonstration of the protective potential of conditioning as a treatment strategy to mitigate ischemia-reperfusion injury. Diabetes modulates multiple metabolic pathways and signal transduction cascades...
2018: Conditioning medicine
Nanfu Luo, Jin Liu, Yan Chen, Huan Li, Zhaoyang Hu, Geoffrey W Abbott
The lungs are highly susceptible to injury, including ischemia/reperfusion (I/R) injury. Pulmonary I/R injury can occur when correcting conditions such as primary pulmonary hypertension, and is also relatively common after lung transplantation or other cardiothoracic surgery. Methods to reduce pulmonary I/R injury are urgently needed to improve outcomes following procedures such as lung transplantation. Remote liver ischemic preconditioning (RLIPC) is an effective cardioprotective measure, reducing damage caused by subsequent cardiac I/R injury, but little is known about its potential role in pulmonary protection...
2018: PloS One
Scott Cocking, N T Cable, Mathew G Wilson, Daniel J Green, Dick H J Thijssen, Helen Jones
Introduction: The ability of ischemic preconditioning (IPC) to enhance exercise capacity may be mediated through altering exercise-induced blood flow and/or vascular function. This study investigated the hypothesis that (local) IPC enhances exercise-induced blood flow responses and prevents decreases in vascular function following exercise. Methods: Eighteen healthy, recreationally trained, male participants (mean ± SD : age 32 ± 8 years; BMI 24.2 ± 2.3; blood pressure 122 ± 10/72 ± 8 mmHg; resting HR 58 ± 9 beats min-1 ) received IPC (220 mmHg; 4 × 5-min bilateral arms), REMOTE IPC (220 mmHg; 4 × 5-min bilateral legs), or SHAM (20 mmHg; 4 × 5-min bilateral arms) in a counterbalanced order prior to 30-min of submaximal (25% maximal voluntary contraction) unilateral rhythmic handgrip exercise...
2018: Frontiers in Physiology
Li Song, Hongbing Yan, Peng Zhou, Hanjun Zhao, Chen Liu, Zhaoxue Sheng, Yu Tan, Yi Chen, Jiannan Li, Jinying Zhou
BACKGROUND: Remote ischemic conditioning (RIC) applied during or after an ST-segment elevation myocardial infarction (STEMI) is currently the most promising adjuvant therapy to reduce reperfusion injury. Recent animal studies showed that RIC may help the myocardium recover if applied daily during the month after an STEMI. METHODS: The CORIC-MI trial is a single-center, randomized controlled study. 200 patients undergoing primary percutaneous coronary intervention (PPCI) for anterior STEMI will be randomized in a 1:1 ratio into comprehensive RIC (CORIC) or no intervention (control)...
May 3, 2018: Clinical Cardiology
Patrick J Griffin, Luke Hughes, Conor Gissane, Stephen D Patterson
BACKGROUND: The aim of this study was to compare the effect of local and remote ischemic preconditioning (IPC) on repeated sprint exercise. METHODS: Twelve males (age 22 ± 2 years; stature 1.79±0.07 m; body mass 77.8±8.4 kg; mean ± SD) completed four trials consisting of remote (arm) and local (leg) IPC and SHAM interventions prior to repeated sprint exercise (3 x (6 x 15 + 15-m) shuttle sprints), in a double-blind, randomised, crossover designed study. These tests were immediately preceded by IPC (4 x 5 minute intervals at 220 mmHg bilateral occlusion) or SHAM treatment (4 x 5 minute intervals at 20 mmHg bilateral occlusion)...
May 2, 2018: Journal of Sports Medicine and Physical Fitness
Lovedeep Singh, Ritu Kulshrestha, Nirmal Singh, Amteshwar Singh Jaggi
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic and remote preconditioning and its release may impart cardioprotection. Exogenous administration of adenosine in the form of adenosine preconditioning may also protect heart from ischemia-reperfusion injury. Endogenous release of adenosine during ischemic/remote preconditioning or exogenous adenosine during pharmacological preconditioning activates adenosine receptors to activate plethora of mechanisms, which either independently or in association with one another may confer cardioprotection during ischemia-reperfusion injury...
May 2018: Korean Journal of Physiology & Pharmacology
Muzaffer Akkoca, Suzan Emel Usanmaz, Serhat Tokgöz, Cüneyt Köksoy, Emine Demirel-Yilmaz
BACKGROUND: Intermittent ischemia in remote tissues can be applied before ischemic injury, during ischemic injury or at the beginning of reperfusion of an index organ ischemia. The aim of this study was to investigate the effect of Remote Ischemic Conditioning (RIC) of the leg on changes in ischemia-induced the microvascular functions of the arm. MATERIAL AND METHODS: Ischemic microvascular injury was induced by arm ischemia (20 min) and reperfusion in healthy, nonsmoker, male volunteers (ischemia group-ISC, n: 9)...
April 13, 2018: Clinical Hemorheology and Microcirculation
Zoltan Czigany, Christian Bleilevens, Christian Beckers, Christian Stoppe, Michaela Möhring, Andras Fülöp, Attila Szijarto, Georg Lurje, Ulf P Neumann, René H Tolba
BACKGROUND: Ischemic-reperfusion (IR) injury still represents a major concern in clinical transplantation, especially in the era of extreme organ shortage and extended criteria donor organs. In the present study we aimed to investigate the hepatoprotective effects of remote ischemic conditioning (RIC) in a rat model of arterialized orthotopic liver transplantation (OLT). METHODS: Male Lewis rats were used (n = 144 / 72 OLT cases; 240-340g) as donors and recipients...
2018: PloS One
Fabrice Prunier, Delphine Mirebeau-Prunier
No abstract text is available yet for this article.
January 2018: Journal of Thoracic Disease
Marie Hauerslev, Sivagowry Rasalingam Mørk, Kasper Pryds, Hussain Contractor, Jan Hansen, Nichlas Riise Jespersen, Jacob Johnsen, Gerd Heusch, Petra Kleinbongard, Rajesh Kharbanda, Hans Erik Bøtker, Michael Rahbek Schmidt
Remote ischemic conditioning (RIC) protects against sustained myocardial ischemia. Due to overlapping mechanisms this protection may be altered by glyceryl trinitrate (GTN), which is commonly used in the treatment of patients with chronic ischemic heart disease. We investigated whether long-term GTN treatment modifies the protection by RIC in rat myocardium and human endothelium. We studied infarct size (IS) in rat hearts subjected to global ischemia-reperfusion (I/R) in vitro and endothelial function in healthy volunteers subjected to I/R of the upper arm...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Bence Hegyi, Julie Bossuyt, Leigh G Griffiths, Rafael Shimkunas, Zana Coulibaly, Zhong Jian, Kristin N Grimsrud, Claus S Sondergaard, Kenneth S Ginsburg, Nipavan Chiamvimonvat, Luiz Belardinelli, András Varró, Julius G Papp, Piero Pollesello, Jouko Levijoki, Leighton T Izu, W Douglas Boyd, Tamás Bányász, Donald M Bers, Ye Chen-Izu
Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires detailed understanding of electrophysiological remodeling. However, changes of ionic currents in ischemic HF remain incompletely understood, especially in translational large-animal models. Here, we systematically measure the major ionic currents in ventricular myocytes from the infarct border and remote zones in a porcine model of post-MI HF. We recorded eight ionic currents during the cell's action potential (AP) under physiologically relevant conditions using self AP-clamp sequential dissection...
March 27, 2018: Proceedings of the National Academy of Sciences of the United States of America
Gerd Heusch
No abstract text is available yet for this article.
March 7, 2018: Basic Research in Cardiology
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