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Remote ischemic conditioning

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https://www.readbyqxmd.com/read/30601408/the-role-of-macrophage-migration-inhibitory-factor-in-remote-ischemic-conditioning-induced-hepatoprotection-in-a-rodent-model-of-liver-transplantation
#1
Christoph Emontzpohl, Christian Stoppe, Alexander Theißen, Christian Beckers, Ulf P Neumann, Georg Lurje, Cynthia Ju, Jürgen Bernhagen, René H Tolba, Zoltan Czigany
BACKGROUND: Macrophage migration inhibitory factor (MIF) is an important stress-regulating mediator of acute ischemia/reperfusion (I/R) injury and ischemic conditioning. The present study aimed to investigate whether MIF is involved in the effects of remote ischemic conditioning (RIC) in a rat model of orthotopic liver transplantation (OLT). METHODS: OLTs were performed in male Lewis rats (245-340 g). Recipients were allocated in a randomized fashion into three experimental groups: remote preconditioning-RIPC, remote postconditioning-RIPOST, control...
December 21, 2018: Shock
https://www.readbyqxmd.com/read/30597638/ischemic-and-hypoxic-conditioning-potential-for-protection-of-vital-organs
#2
Justin D Sprick, Robert T Mallet, Karin Przyklenk, Caroline A Rickards
NEW FINDINGS: What is the topic of this review? Paradoxically, ischemic and hypoxic conditioning paradigms protect vital organs from ischemic and hypoxic injury. In this Symposium Report, we focus on remote ischemic preconditioning (RIPC) and hypoxic preconditioning as novel therapeutic approaches for cardiac- and neuro-protection. What advances does it highlight? Growing interest in ischemic and hypoxic preconditioning has facilitated improved understanding of associated mechanisms and signaling pathways, and identified potential pitfalls with application of these therapies to clinical trials...
December 31, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/30584132/renal-ischemia-reperfusion-induced-metabolic-and-micro-rheological-alterations-and-their-modulation-by-remote-organ-ischemic-preconditioning-protocols-in-the-rat
#3
Gabor Varga, Souleiman Ghanem, Balazs Szabo, Kitti Nagy, Noemi Pal, Bence Tanczos, Viktoria Somogyi, Barbara Barath, Adam Deak, Katalin Peto, Norbert Nemeth
BACKGROUND: Pathomechanism and optimal renoprotective protocol for remote ischemic preconditioning (RIPC) have not been completely revealed yet. OBJECTIVE: To investigate micro-rheological effects of early and delayed RIPC in renal ischemia-reperfusion (I/R) in the rat. METHODS: In Control group the left femoral artery was cannulated and the left kidney was gently exposed. In the I/R group 45-minute renal ischemia with 120-minute reperfusion period was monitored...
December 17, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/30575436/cardioprotection-via-the-skin-nociceptor-induced-conditioning-against-cardiac-mi-in-the-nic-of-time
#4
Xiaoping Ren, Anne E Roessler, Thomas L Lynch, Lauren Haar, Faryal Mallick, Yong Liu, Michael Tranter, Michelle Ren, Wen Rui Xie, Guo-Chang Fan, Jun-Ming Zhang, Evangelia Kranias, Ahmad Anjak, Sheryl E Koch, Min Jiang, Sarat Dass, Albert Cohen, Jack Rubinstein, Neal L Weintraub, W Keith Jones
Timely reperfusion is still the most effective approach to limit infarct size in man. Despite advances in care and reduction in door-to-balloon times, nearly 25% of pa-tients develop heart failure post-MI, with its attendant morbidity and mortality. We pre-viously showed that cardioprotection results from a skin incision through the umbilicus in a murine model of myocardial infarction. In this study, we show that an electrical stimulus (ES) or topical capsaicin applied to the skin in the same region induces signif-icantly reduced infarct size in a murine model...
December 21, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30574423/remote-ischemic-conditioning-protects-diabetic-retinopathy-in-streptozotocin-induced-diabetic-rats-via-anti-inflammation-and-antioxidation
#5
Changhong Ren, Hang Wu, Dongjie Li, Yong Yang, Yuan Gao, Yunneng Jizhang, Dachuan Liu, Xunming Ji, Xuxiang Zhang
Ischemic conditioning inhibits oxidative stress and inflammatory response in diabetes. However, whether limb remote ischemic conditioning (LRIC) has beneficial effects on diabetic retinopathy (DR) remains unknown. This study aims to investigate the protective effects of LRIC in retinal ganglion cell in streptozotocin (STZ) induced Type 1 diabetic rats. A total of 48 healthy male Sprague-Dawley (200-220g) rats were randomly assigned to the normal group, normal+LRIC group, diabetes mellitus (DM) group and DM+LRIC group...
December 2018: Aging and Disease
https://www.readbyqxmd.com/read/30571433/remote-ischemic-conditioning-for-preventing-and-treating-ischemic-stroke
#6
Wenbo Zhao, Jing Zhang, Mordechai Sadowsky, Ran Meng, Yuchuan Ding, Xunming Ji
No abstract text is available yet for this article.
December 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/30556056/the-role-of-platelets-in-ischemic-conditioning
#7
Juan Alpuche, Luz Quírino, José T Sánchez-Vega, Jonathan Yap, Eduardo Pérez-Campos, Hector A Cabrera-Fuentes
Ischemic heart disease (IHD) is one of the leading causes of death and disability worldwide. Platelets, as the main regulators of hemostasis, are major players in acute myocardial ischemia/reperfusion injury (IRI). Additionally, platelets are modified by endogenous cardioprotective strategies such as ischemic preconditioning, postconditioning, and remote ischemic conditioning. In this article, we provide an overview of the functionional role of platelets in acute myocardial IRI, and highlight their potential as targets for cardioprotection to improve health outcomes in patients with IHD...
October 2018: Conditioning medicine
https://www.readbyqxmd.com/read/30526689/induced-pluripotent-stem-cell-derived-endothelial-progenitor-cells-attenuate-ischemic-acute-kidney-injury-and-cardiac-dysfunction
#8
Wen-Ching Shen, Yu-Hsiang Chou, Hsiang-Po Huang, Jenn-Feng Sheen, Shih-Chieh Hung, Hsin-Fu Chen
BACKGROUND: Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy for AKI is an unmet clinical need, and molecular mechanisms underlying the interactions between an injured kidney and distant organs remain unclear. Therefore, novel therapeutic strategies should be developed. METHODS: We directed the differentiation of human induced pluripotent stem (iPS) cells into endothelial progenitor cells (iEPCs), which were then applied for treating mouse AKI...
December 10, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30507251/tefillin-use-induces-remote-ischemic-preconditioning-pathways-in-healthy-men
#9
A Phillip Owens, Nathan Robbins, Keith Saum, Shannon M Jones, Akiva Kirschner, Jessica G Woo, Connie McCoy, Samuel Slone, Marc E Rothenberg, Elaine M Urbina, Michael Tranter, Jack Rubinstein
The present study assessed whether tefillin use (tight, nonocclusive, wrapping of the arm) elicits a remote ischemic preconditioning (RIPC)-like effect in subjects with both acute and chronic use. RIPC, created by short bursts of ischemia-reperfusion, has not been successfully taken to the bedside. Several large population studies have found that Orthodox Jewish men (who wear tefillin almost daily) have decreased cardiovascular mortality compared with non-Orthodox counterparts. We hypothesized that tefillin use is a relevant component in triggering a preconditioning effect...
December 1, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30502312/remote-ischemic-conditioning-in-a-rat-model-of-testicular-torsion-does-it-offer-testicular-protection
#10
M Mansour, J Degheili, I Khalifeh, H Tamim, R F Jaafar, Y El-Hout
BACKGROUND: Testicular torsion is a surgical emergency mainly affecting adolescent boys, with a relatively high rate of missed torsion and testicular loss secondary to delay in prompt diagnosis and surgical intervention. With ischemic reperfusion injury as its underlying culprit, testicular torsion may respond favorably to remote ischemic conditioning (RIC) where a non-privileged site (e.g. limb) is concurrently rendered ischemic to divert the cascade of reperfusion injury from the privileged organ (e...
September 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/30501397/remote-ischemic-per-conditioning-protects-against-renal-ischemia-reperfusion-injury-via-suppressing-gene-expression-of-tlr4-and-tnf-%C3%AE-in-rat-model
#11
Firouzeh Gholampour, Jamshid Roozbeh, Sahar Janfeshan, Zeinab Karimi
BACKGROUND: The pathogenesis of renal ischemic reperfusion injury (IRI) involves both inflammatory processes and oxidative stress in the kidney. This study determined whether remote ischemic per-conditioning (RIPerC) is mediated by toll-like receptor 4 (TLR4) signaling pathway in rats. MATERIALS AND METHODS: Renal I/R injury was induced by occluding renal arteries for 45 min followed by 24 h reperfusion. RIPerC included four cycles of 2 minutes ischemia of left femoral artery followed by 3 minutes reperfusion performed at the start of renal ischemia...
December 2, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/30439443/intracranial-atherosclerotic-disease
#12
Yuan Wang, Ran Meng, Gang Liu, Catherine Cao, Fenghua Chen, Kunlin Jin, Xunming Ji, Guodong Cao
Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging...
November 12, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/30403148/nrf2-regulates-the-hepatoprotective-effects-of-remote-ischemic-conditioning-in-hemorrhagic-shock
#13
Chung Ho Leung, Christopher A Caldarone, Rui Guan, Xiao-Yan Wen, Menachem Ailenberg, Andras Kapus, Katalin Szaszi, Ori D Rotstein
AIMS: Remote ischemic conditioning (RIC) protects against organ ischemia/reperfusion injury in experimental and clinical settings. We have demonstrated that RIC prevents liver and lung inflammation/injury following hemorrhagic shock/resuscitation (S/R). In the current study, we used a murine model of S/R to investigate the role of Nrf2 in mediating hepatoprotection. RESULTS: The combination of RIC with S/R caused a synergistic rise in Nrf2 and its translocation to the nucleus in the liver...
November 7, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/30371229/mitochondrial-and-contractile-function-of-human-right-atrial-tissue-in-response-to-remote-ischemic-conditioning
#14
Petra Kleinbongard, Nilguen Gedik, Mücella Kirca, Leanda Stoian, Ulrich Frey, Afsaneh Zandi, Matthias Thielmann, Heinz Jakob, Jürgen Peters, Markus Kamler, Gerd Heusch
Background Remote ischemic preconditioning ( RIPC ) by repeated brief cycles of limb ischemia/reperfusion attenuates myocardial ischemia/reperfusion injury. We aimed to identify a functional parameter reflecting the RIPC -induced protection in human. Therefore, we measured mitochondrial function in right atrial tissue and contractile function of isolated right atrial trabeculae before and during hypoxia/reoxygenation from patients undergoing coronary artery bypass grafting with RIPC or placebo, respectively...
August 7, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/30359199/vago-splenic-axis-in-signal-transduction-of-remote-ischemic-preconditioning-in-pigs-and-rats
#15
Helmut Raphael Lieder, Petra Kleinbongard, Andreas Skyschally, Helene Hagelschuer, William M Chilian, Gerd Heusch
RATIONALE: The signal transduction of remote ischemic conditioning is still largely unknown. OBJECTIVE: Characterization of neurohumoral signal transfer and vago-splenic axis in remote ischemic preconditioning (RIPC). METHODS AND RESULTS: Anesthetized pigs were subjected to 60 minutes of coronary occlusion and 180 minutes of reperfusion (placebo+ischemia/reperfusion [PLA+I/R]). RIPC was induced by 4×5/5 minutes of hindlimb I/R 90 minutes before coronary occlusion (RIPC+I/R)...
October 26, 2018: Circulation Research
https://www.readbyqxmd.com/read/30338313/remote-ischemic-conditioning-in-st-segment-elevation-myocardial-infarction-an-update
#16
Jun Chong, Heerajnarain Bulluck, En Ping Yap, Andrew Fw Ho, William A Boisvert, Derek J Hausenloy
Acute myocardial infarction (AMI) and the heart failure (HF) that often results are among the leading causes of death and disability in the world. As such, novel strategies are required to protect the heart against the detrimental effects of acute ischemia/reperfusion injury (IRI), in order to reduce myocardial infarct (MI) size and prevent the onset of HF. The endogenous cardioprotective strategy of remote ischemic conditioning (RIC), in which cycles of brief ischemia and reperfusion are applied to a tissue or organ away from the heart, has been reported in experimental studies to reduce MI size in animal models of acute IRI...
August 2018: Conditioning medicine
https://www.readbyqxmd.com/read/30295166/remote-post-conditioning-and-allopurinol-reduce-ischemia-reperfusion-injury-in-an-infra-renal-ischemia-model
#17
Rafael Inácio Brandão, Ricardo Zanetti Gomes, Luana Lopes, Filipe Silva Linhares, José Carlos Rebuglio Vellosa, Katia Sabrina Paludo
BACKGROUND: The aim of this study was to evaluate the effects of the antioxidant allopurinol and ischemic post-conditioning on the deleterious effects of ischemia followed by reperfusion (I/R) in a standardized model of ischemia involving infra-renal aortic occlusion in rats. METHODS: The animals were randomly divided into five groups: (A) animals not subjected to ischemia; (B) animals subjected to 2 h of ischemia and reperfusion only once; (C) animals given an allopurinol dose by gavage, then subjected to 2 h of ischemia and reperfusion only once; (D) animals subjected to 2 h of ischemia and post-conditioning and (E) animals that received allopurinol, then subjected to 2 h of ischemia and post-conditioning...
October 8, 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/30278263/remote-ischemic-preconditioning-in-the-management-of-intermittent-claudication-a-pilot-randomized-controlled-trial
#18
Khalid Mt Ahmed, Shannon Hernon, Sara Mohamed, Muhammed Tubassum, Michael Newell, Stewart R Walsh
OBJECTIVE: To evaluate Remote ischaemic preconditioning in management of intermittent claudication patients BACKGROUND: Animal data suggest that remote ischaemic conditioning (RIC) can improve blood flow in ischaemic limbs and, consequently, may benefit claudication patients Supervised exercise is the preferred first-line intervention for patients with intermittent claudication (IC) but is constrained by limited availability and logistical issues, particularly in rural settings METHODS: We undertook a randomised clinical trial to evaluate RIC's effect in claudication patients...
September 29, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30272816/remote-ischemic-conditioning-as-a-cytoprotective-strategy-in-vasculopathies-during-hyperhomocysteinemia-an-emerging-research-perspective
#19
Avisek Majumder, Mahavir Singh, Akash K George, Rubens Petit Homme, Anwesha Laha, Suresh C Tyagi
Higher levels of nonprotein amino acid homocysteine (Hcy), that is, hyperhomocysteinemia (HHcy) (~5% of general population) has been associated with severe vasculopathies in different organs; however, precise molecular mechanism(s) as to how HHcy plays havoc with body's vascular networks are largely unknown. Interventional modalities have not proven beneficial to counter multifactorial HHcy's effects on the vascular system. An ancient Indian form of exercise called 'yoga' causes transient ischemia as a result of various body postures however the cellular mechanisms are not clear...
January 2019: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30271664/limb-ischemic-conditioning-improved-cognitive-deficits-via-enos-dependent-augmentation-of-angiogenesis-after-chronic-cerebral-hypoperfusion-in-rats
#20
Changhong Ren, Ning Li, Sijie Li, Rongrong Han, Qingjian Huang, Jiangnan Hu, Kunlin Jin, Xunming Ji
Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral hypoperfusion (CCH), is a critical reason for the pathogenesis of vascular dementia and Alzheimer's disease characterized by cognitive impairments. Our previous study demonstrated that limb remote ischemic conditioning (LRIC) improved cerebral perfusion in intracranial arterial stenosis patients. The current study aimed to test whether LRIC promotes angiogenesis and increases phosphorylated endothelial nitric oxide synthase (p-eNOS) activity in CCH rat model...
October 2018: Aging and Disease
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