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Remote ischemic conditioning

Bence Hegyi, Julie Bossuyt, Leigh G Griffiths, Rafael Shimkunas, Zana Coulibaly, Zhong Jian, Kristin N Grimsrud, Claus S Sondergaard, Kenneth S Ginsburg, Nipavan Chiamvimonvat, Luiz Belardinelli, András Varró, Julius G Papp, Piero Pollesello, Jouko Levijoki, Leighton T Izu, W Douglas Boyd, Tamás Bányász, Donald M Bers, Ye Chen-Izu
Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires detailed understanding of electrophysiological remodeling. However, changes of ionic currents in ischemic HF remain incompletely understood, especially in translational large-animal models. Here, we systematically measure the major ionic currents in ventricular myocytes from the infarct border and remote zones in a porcine model of post-MI HF. We recorded eight ionic currents during the cell's action potential (AP) under physiologically relevant conditions usingself AP-clamp sequential dissection...
March 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
Gerd Heusch
No abstract text is available yet for this article.
March 7, 2018: Basic Research in Cardiology
Gerd Heusch
No abstract text is available yet for this article.
April 15, 2018: International Journal of Cardiology
Hans Erik Botker, Thomas Ravn Lassen, Nichlas Riise Jespersen
Rapid admission and acute interventional treatment combined with modern antithrombotic pharmacologic therapy have improved outcome in patients with ST-elevation myocardial infarction. The next major target to further improve outcome, seems to be ischemia reperfusion injury, which may contribute significantly to the final infarct size and hence mortality and post-infarction heart failure. Mechanical conditioning strategies including local and remote ischemic pre-, per- and postconditioning have demonstrated consistent cardioprotective capacities in experimental models of acute IR injury...
March 2, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Hai Liu, Li Fu, Xiangke Sun, Wei Peng, Zhiwei Chen, Yiliang Li
We conducted a systematic review and meta-analysis to evaluate the effects of remote ischemic conditioning on myocardial parameters and clinical outcomes in ST segment elevation acute myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention. Ten eligible randomized controlled trials with 1006 STEMI patients were identified. Compared with controls, remote ischemic conditioning reduced the myocardial enzyme levels (standardized mean difference =-0.86; 95% CI: -1.44 to -0.28; P = 0...
February 2, 2018: Oncotarget
Gangling Chen, Mrugesh Thakkar, Christopher Robinson, Sylvain Doré
Novel and innovative approaches are essential in developing new treatments and improving clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a series of mechanical interruptions in blood flow of a distal organ, following end organ reperfusion, shown to significantly reduce infarct size through inhibition of oxidation and inflammation. Ischemia/reperfusion (I/R) is what ultimately leads to the irreversible brain damage and clinical picture seen in stroke patients. There have been several reports and reviews about the potential of RIC in acute ischemic stroke; however, the focus here is a comprehensive look at the differences in the three types of RIC (remote pre-, per-, and postconditioning)...
2018: Frontiers in Neurology
Petra Kleinbongard, Georgios Amanakis, Andreas Skyschally, Gerd Heusch
<u>Rationale:</u> Reduction of infarct size (IS) by remote ischemic per-conditioning (perRIC) is evident only after several hours reperfusion. <u>Objective:</u> To develop a potential real-time estimate of cardioprotection by perRIC we have analyzed the time course of ST-segment elevation. <u>Methods and Results:</u> Anesthetized open-chest pigs were subjected to 60 min coronary occlusion and 180 min reperfusion (placebo; PLA; n=19). perRIC (n=18; 4x5 min/5 min hindlimb occlusion/reperfusion) was induced 20 min after coronary occlusion...
February 21, 2018: Circulation Research
Xue Cheng, Haiping Zhao, Feng Yan, Zhen Tao, Rongliang Wang, Ziping Han, Guangwen Li, Yumin Luo, Xunming Ji
Maladaptive alterations of astrocytic plasticity may cause brain edema in the acute stage of stroke and glial scar formation in the recovery stage. The present study was designed to investigate the potential regulation of limb remote ischemic post-conditioning (RIPC) on astrocytic plasticity in experimental cerebral ischemia-reperfusion injury. Cerebral ischemia was induced by transient middle cerebral artery occlusion (tMCAO) for 1 h in C57BL/6 mice, who were treated with RIPC immediately after reperfusion...
February 17, 2018: Brain Research
Viraj Pandit, Muhammad Khan, El Rasheid Zakaria, Tally M Largent-Milnes, Mohammad Hamidi, Terence O'Keeffe, Todd W Vanderah, Bellal Joseph
INTRODUCTION: While studies show that single-dose remote ischemic conditioning (RIC) improves outcomes, the effect of continuous (daily) RIC is unknown. Thus, we aimed to investigate the role of continuous-RIC on cognitive and motor function following traumatic brain injury (TBI). METHODS: We subjected 24 male C57BL mice to a cortical-controlled TBI. Two-hours after TBI the animals were randomly allocated to the RIC group (n=12) or the Sham group (n=12). RIC was induced by non-invasive external compression of the hind limb using an occlusive band (six 4-min cycles/24 hours) for consecutive 6 days...
February 14, 2018: Journal of Trauma and Acute Care Surgery
Sang-Bing Ong, Khairunnisa Katwadi, Xiu-Yi Kwek, Nur Izzah Ismail, Sang-Ging Ong, Kroekkiat Chinda, Derek J Hausenloy
New treatments are required to improve clinical outcomes in patients with acute myocardial infarction (AMI), for reduction of myocardial infarct (MI) size and preventing heart failure. Following AMI, acute ischemia/reperfusion injury (IRI) ensues, resulting in cardiomyocyte death and impaired cardiac function. Emerging studies have implicated a fundamental role for non-coding RNAs (microRNAs [miRNA], and more recently long non-coding RNAs [lncRNA]) in the setting of acute myocardial IRI. Areas covered: In this article, we discuss the roles of miRNAs and lncRNAs as potential biomarkers and therapeutic targets for the detection and treatment of AMI, review their roles as mediators and effectors of cardioprotection, particularly in the settings of interventions such as ischemic pre- and post-conditioning (IPC & IPost) as well as remote ischemic conditioning (RIC), and highlight future strategies for targeting ncRNAs to reduce MI size and prevent heart failure following AMI...
February 8, 2018: Expert Opinion on Therapeutic Targets
Dan Liang, Xi-Biao He, Zheng Wang, Ce Li, Bei-Yao Gao, Jun-Fa Wu, Yu-Long Bai
AIMS: Remote ischemic conditionings, such as pre- and per-conditioning, are known to provide cardioprotection in animal models of ischemia. However, little is known about the neuroprotection effect of postconditioning after cerebral ischemia. In this study, we aim to evaluate the motor function rescuing effect of remote limb ischemic postconditioning (RIPostC) in a rat model of acute cerebral stroke. METHODS: Left middle cerebral artery occlusion (MCAO) was performed to generate the rat model of ischemic stroke, followed by daily RIPostC treatment for maximum 21 days...
February 4, 2018: CNS Neuroscience & Therapeutics
Kazuo Kitagawa, Moeko Saitoh, Kentaro Ishizuka, Satoru Shimizu
BACKGROUND: Remote ischemic conditioning (RIC) induces protection in focal cerebral ischemia. The conditioning is divided into pre-, per-, and postconditioning. However, the mechanisms of RIC remain unknown. OBJECTIVES: This study aimed to determine the most effective subtype of RIC. We also examined involvement of collateral circulation on RIC. METHODS: Transient middle cerebral artery occlusion (MCAO) was performed with nylon sutures in adult C57BL/6 mice under the monitoring of cerebral blood flow (CBF)...
January 29, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Wenbo Zhao, Sijie Li, Changhong Ren, Ran Meng, Xunming Ji
Chronic remote ischemic conditioning (RIC), particularly long-term repeated RIC, has been applied in clinical trials with the expectation that it could play its protective roles for protracted periods. In sports medicine, chronic RIC has also been demonstrated to improve exercise performance, akin to improvements seen with regular exercise training. Therefore, chronic RIC may mimic regular exercise, and they may have similar underlying mechanisms. In this study, we explored the common underlying mechanisms of chronic RIC and physical exercise in protecting multiple organs and benefiting various populations, the advantages of chronic RIC, and the challenges for its popularization...
February 2018: Aging and Disease
Shi-Meng Liu, Wen-Le Zhao, Hai-Qing Song, Ran Meng, Si-Jie Li, Chang-Hong Ren, Bruce Ovbiagele, Xun-Ming Ji, Wu-Wei Feng
BACKGROUND: Acute minor ischemic stroke (AMIS) or transient ischemic attack (TIA) is a common cerebrovascular event with a considerable high recurrence. Prior research demonstrated the effectiveness of regular long-term remote ischemic conditioning (RIC) in secondary stroke prevention in patients with intracranial stenosis. We hypothesized that RIC can serve as an effective adjunctive therapy to pharmacotherapy in preventing ischemic events in patients with AMIS/TIA. This study aimed to investigate the feasibility, safety, and preliminary efficacy of daily RIC in inhibiting cerebrovascular/cardiovascular events after AMIS/TIA...
February 5, 2018: Chinese Medical Journal
Andreas Engel Krag, Christine Lodberg Hvas, Birgitte Jul Kiil, Gete Toft Eschen, Tine Engberg Damsgaard, Anne-Mette Hvas
BACKGROUND: Remote ischemic conditioning (RIC) administered by non-lethal periods of extremity ischemia and reperfusion attenuates ischemia-reperfusion injury. We aimed to investigate the local and systemic coagulation marker response to flap ischemia-reperfusion injury, and the effects of RIC on coagulation markers following flap ischemia-reperfusion injury. METHODS: A musculocutaneous latissimus dorsi flap was subjected to 4 h of ischemia followed by 7 h of reperfusion in 16 female Danish Landrace pigs (39 kg)...
January 8, 2018: Microsurgery
Gerd Heusch
No abstract text is available yet for this article.
February 1, 2018: International Journal of Cardiology
Petra Kleinbongard, Andreas Skyschally, Sabine Gent, Marion Pesch, Gerd Heusch
Ischemic conditioning before (ischemic preconditioning, IPC) or after (ischemic postconditioning, POCO) sustained myocardial ischemia/reperfusion (I/R), induced locally or remotely from the heart (remote IPC, RIPC), reduces infarct size. However, none of the identified signaling steps of ischemic conditioning was robust across models and species to be successfully translated to humans. In prior separate studies in pigs, activation of signal transducer and activator of transcription 3 (STAT3) was causal for infarct size reduction by IPC, POCO, and RIPC but it remains unclear whether or not STAT3 is truly a common denominator of cardioprotective signaling...
November 20, 2017: Basic Research in Cardiology
Xiang Hu, Tao Lv, Shao-Feng Yang, Xiao-Hua Zhang, Yi-Feng Miao
Hemorrhage‑related neurologic injury is a primary cause of disability and mortality following subarachnoid hemorrhage (SAH). The aim of the present study was to investigate the potential neuroprotective effect and the possible role of autophagy in limb remote ischemic post‑conditioning (RIPostC) using an endovascular puncture rat model of SAH. RIPostC was induced by three cycles of occlusion (10 min) and release (10 min) in the bilateral femoral artery using an aneurysm clip. Early RIPostC began immediately following SAH, delayed RIPostC began following a 30 min delay and the repeated RIPostC group underwent the protocol every day for 3 days...
January 2018: Molecular Medicine Reports
Chang-Cheng Zhou, Wen-Tao Yao, Yu-Zheng Ge, Lu-Wei Xu, Ran Wu, Xiao-Fei Gao, Kai-Wei Song, Xiao-Min Jiang, Min Wang, Wen-Juan Huang, Yun-Peng Zhu, Liang-Peng Li, Liu-Hua Zhou, Zhong-Le Xu, Sheng-Li Zhang, Jia-Geng Zhu, Wen-Cheng Li, Rui-Peng Jia
Objective: We conducted this meta-analysis to examine the effect of remote ischemic conditioning (RIC) on contrast-induced acute kidney injury (CI-AKI) in patients undergoing intravascular contrast administrationon. Methods: Pubmed, Embase, and Cochrane Library were comprehensively searched to identify all eligible studies by 15th March, 2017. Risk ratio (RR) and weighted mean difference with the corresponding 95% confidence intervals (CI) were used to examine the treatment effect...
October 3, 2017: Oncotarget
Takehiko Fukui, Kazuyoshi Ishida, Yoichi Mizukami, Kiyotaka Shiramoto, Hidenori Harada, Atsuo Yamashita, Satoshi Yamashita, Mishiya Matsumoto
INTRODUCTION: This study aimed to determine the relative potency of direct ischemic preconditioning (DIPC) and remote ischemic preconditioning (RIPC) for protection against ischemic spinal cord injury in rabbits and to explore the mechanisms involved. METHODS: In experiment 1, we compared the neurological and histopathological outcomes of DIPC, kidney RIPC, and limb RIPC. The DIPC and kidney RIPC groups received two cycles of 5-min occlusion/15-min reperfusion of the abdominal aorta and left renal artery, respectively...
November 1, 2017: Journal of Anesthesia
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