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Remote ischemic conditioning

Kendra M Cherry-Allen, Jeff M Gidday, Jin-Moo Lee, Tamara Hershey, Catherine E Lang
The authors tested whether 2 doses of remote limb ischemic conditioning (RLIC), induced via blood pressure cuff inflation, enhanced motor and cognitive learning to an equal extent, and explored a panel of blood biomarkers of RLIC. Thirty-two young adults were randomized to 3 groups and underwent a 7-day protocol of RLIC/sham followed by motor and cognitive training, with follow-up. Both RLIC groups had greater motor learning and a trend toward greater cognitive learning compared with the sham group. RLIC at the lower inflation pressure was as effective as RLIC with the higher inflation pressure...
October 12, 2016: Journal of Motor Behavior
Alice Brandli, Daniel M Johnstone, Jonathan Stone
Purpose: To test whether remote ischemic preconditioning (RIP) is protective to photoreceptors, in a light damage model, and to identify mechanisms involved. Methods: A pressure cuff was used to induce ischemia (2 × 5 minutes) in one hind limb of 4- to 6-month-old albino Sprague-Dawley rats raised in dim, cyclic light (12 hours 5 lux, 12 hours dark). Immediately following the ischemia, rats were exposed to bright continuous light (1000 lux) for 24 hours. After 7-day survival in dim, cyclic light conditions, retinal function was assessed using the flash electroretinogram (ERG) and retinal structure was examined for photoreceptor survival and death, as well as for stress...
October 1, 2016: Investigative Ophthalmology & Visual Science
Nicoline Valentina Krogstrup, Mihai Oltean, Gertrude J Nieuwenhuijs-Moeke, Frank J M F Dor, Ulla Møldrup, Søren Palmelund Krag, Bo Martin Bibby, Henrik Birn, Bente Jespersen
Delayed graft function is a frequent complication following deceased donor renal transplantation, and is closely related to ischaemia-reperfusion injury. Experimental and clinical studies have shown protection by remote ischaemic conditioning (RIC). We hypothesised that recipient RIC before kidney graft reperfusion reduces the time to graft recovery. This multicentre, blinded, randomised, controlled clinical trial included 225 adult recipients of renal transplants from deceased donors at four transplantation centres in Denmark, Sweden and the Netherlands...
October 3, 2016: American Journal of Transplantation
T Ravingerova, V Farkasova, L Griecsova, S Carnicka, M Murarikova, E Barlaka, F Kolar, M Bartekova, L Lonek, J Slezak, A Lazou
Remote ischemic preconditioning (RIPC) is a novel strategy of protection against ischemia-reperfusion (IR) injury in the heart (and/or other organs) by brief episodes of non-lethal IR in a distant organ/tissue. Importantly, RIPC can be induced noninvasively by limitation of blood flow in the extremity implying the applicability of this method in clinical situations. RIPC (and its delayed phase) is a form of relatively short-term adaptation to ischemia, similar to ischemic PC, and likely they both share triggering mechanisms, whereas mediators and end-effectors may differ...
September 19, 2016: Physiological Research
Heike A Hildebrandt, Vincent Kreienkamp, Sabine Gent, Philipp Kahlert, Gerd Heusch, Petra Kleinbongard
Although remote ischemic pre-conditioning (RIPC) reduced infarct size in animal experiments and proof-of-concept clinical trials, recent phase III trials failed to confirm cardioprotection during cardiac surgery. Here, we characterized the kinetic properties of humoral factors that are released after RIPC, as well as the signal transduction pathways that were responsible for cardioprotection in an ex vivo model of global ischemia reperfusion injury. Venous blood from 20 healthy volunteers was collected at baseline and 5 min, 30 min, 1 h, 6 h, and daily from 1 to 7 days after RIPC (3 × 5/5 min upper-limb ischemia/reperfusion)...
January 2016: JACC. Basic to Translational Science
Jennifer J Robertson, Alex Koyfman
BACKGROUND: Cervical artery dissection (CeAD) is an infrequent, yet potentially devastating, cause of stroke. While uncommon, CeAD is important for emergency physicians to quickly diagnose and treat because of the potential for cerebral ischemia, stroke, blindness, or death. To our knowledge, no review articles in the emergency medicine literature have been published on CeAD. A literature search of MEDLINE/PubMed, Embase, and other major abstracts in the English language was performed for the following terms: cervical artery, vertebral artery, and carotid artery dissection...
September 12, 2016: Journal of Emergency Medicine
Gerd Heusch, Tienush Rassaf
The mortality from acute myocardial infarction (AMI) remains significant, and the prevalence of post-myocardial infarction heart failure is increasing. Therefore, cardioprotection beyond timely reperfusion is needed. Conditioning procedures are the most powerful cardioprotective interventions in animal experiments. However, ischemic preconditioning cannot be used to reduce infarct size in patients with AMI because its occurrence is not predictable; several studies in patients undergoing surgical coronary revascularization report reduced release of creatine kinase and troponin...
August 19, 2016: Circulation Research
Chenghui Zhou, Yunseok Jeon, Patrick Meybohm, Alexander Zarbock, Paul Jeffrey Young, Lihuan Li, Derek J Hausenloy
BACKGROUND: Remote ischemic conditioning (RIC) has been recognized an emerging non-invasive approach for preventing acute kidney injury (AKI) in patients undergoing either elective coronary artery bypass graft (CABG) surgery or percutaneous coronary intervention (PCI). On the other hand, accumulating evidence has indicated the involving role of pre-CABG contrast usage for coronary angiography in post-surgery AKI risk. Along with the shortening time delay of CABG after coronary angiography, and the prevalent hybrid coronary revascularization (HCR), the AKI prevention by RIC has faced challenges following coronary revascuralization...
November 1, 2016: International Journal of Cardiology
Fernando Pico, Charlotte Rosso, Elena Meseguer, Marie-Laure Chadenat, Amina Cattenoy, Philippe Aegerter, Sandrine Deltour, Jennifer Yeung, Hassan Hosseini, Yves Lambert, Didier Smadja, Yves Samson, Pierre Amarenco
RATIONALE: Remote ischemic per-conditioning-causing transient limb ischemia to induce ischemic tolerance in other organs-reduces final infarct size in animal stroke models. AIM: To evaluate whether remote ischemic per-conditioning during acute ischemic stroke (<6 h) reduces brain infarct size at 24 h. METHODS AND DESIGN: This study is being performed in five French hospitals using a prospective randomized open blinded end-point design...
July 13, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
J Kolbenschlag, A Sogorski, N Kapalschinski, K Harati, M Lehnhardt, A Daigeler, T Hirsch, O Goertz
BACKGROUND: Surgical flaps have become safe and reliable tools in the reconstructive armamentarium. However, total flap loss rates of up to 25% and partial flap loss rates up to 36% are reported in the literature, most often due to insufficient perfusion and the resulting hypoxia. Therefore, a reliable, non-invasive and effective way to improve the microcirculation of surgical flaps is desirable. Remote Ischemic Conditioning (RIC) is the repeated application of non-damaging cycles of ischemia and reperfusion on an organ remote to the tissue to be conditioned...
July 5, 2016: Plastic and Reconstructive Surgery
Jack M J Pickard, Sean M Davidson, Derek J Hausenloy, Derek M Yellon
The cardioprotection afforded by remote ischaemic conditioning (RIC) is mediated via a complex mechanism involving sensory afferent nerves, the vagus nerve, and release of a humoral blood-borne factor. However, it is unknown whether release of the protective factor depends on vagal activation or occurs independently. This study aimed to evaluate the co-dependence of the neural and humoral pathways of RIC, focussing on the vagus nerve and intrinsic cardiac ganglia. In the first study, anesthetised rats received bilateral cervical vagotomy or sham-surgery immediately prior to RIC (4 × 5 min limb ischemia-reperfusion) or sham-RIC...
July 2016: Basic Research in Cardiology
Chengbei Hou, Jiangang Duan, Yumin Luo, Ran Meng, Sijie Li, Chen Yao, Yuchuan Ding, Hongqi Zhang, Yuping Wang, Guoguang Zhao, Jian Zhang, Xunming Ji
OBJECTIVE: The recurrence rate of ischemic stroke remains high among symptomatic intracranial atherosclerotic stenosis patients with either ischemic stroke or transient ischemic attack. The aim of our study is to evaluate whether remote limb ischemic conditioning (RLIC) prevents cerebral ischemic events in symptomatic intracranial atherosclerotic stenosis patients. METHODS: Symptomatic intracranial atherosclerotic stenosis patients with either ischemic stroke or transient ischemic attack will be recruited from more than 60 hospitals in China to participate in a randomized, double-blind, parallel-controlled clinical trial that will compare the efficacy and safety of RLIC for the prevention of recurrent stroke...
October 2016: International Journal of Stroke: Official Journal of the International Stroke Society
René Robert, Mathieu Vinet, Angéline Jamet, Rémi Coudroy
Remote ischemic preconditioning may attenuate renal injury and protect the kidney during subsequent inflammatory or ischemic stress. However, the mechanism of such a protection is not well understood. The aim of this study was to investigate the impact of remote ischemic preconditioning on renal resistivity index (RRI) in nine healthy volunteers. In six volunteers, four cycles of 4-min inflation of a blood pressure cuff were applied to one upper arm, followed by 4-min reperfusion with the cuff deflated. RRI was determined using Doppler echography during each cuff deflated period...
May 19, 2016: Journal of Nephrology
Noha M Abogresha, Sahar Mansour Greish, Eman Z Abdelaziz, Waleed F Khalil
INTRODUCTION: Recent studies have demonstrated remote effects of renal ischemia/reperfusion (IR) injury on some organs such as brain, liver, and lungs. Oxidative stress is reported to be the cornerstone in such ischemic conditions. Associated apoptosis is also reported in remote lung, liver and myocardial injury after acute kidney injury. So, we postulated that renal IR may affect the pancreas by its remote effect. Oxidative stress and mitochondrial mediated apoptosis may play a crucial role in this injury...
April 1, 2016: Archives of Medical Science: AMS
Hug Aubin, George Petrov, Hannan Dalyanoglu, Diyar Saeed, Payam Akhyari, Gerrit Paprotny, Maximillian Richter, Ralf Westenfeld, Hubert Schelzig, Malte Kelm, Detlef Kindgen-Milles, Artur Lichtenberg, Alexander Albert
OBJECTIVES: This study sought to evaluate patient outcome within the Düsseldorf Extracorporeal Life Support (ECLS) Network, a suprainstitutional network for rapid-response remote ECLS and to define survival-based predictors. BACKGROUND: Mobile venoarterial extracorporeal membrane oxygenation (vaECMO) used for ECLS has become a treatment option for a patient population with an otherwise fatal prognosis. However, outcome data remain scarce and institutional standards required to manage these patients are still poorly defined...
September 2016: JACC. Heart Failure
Gerd Heusch
The atherosclerotic coronary vasculature is not only the culprit but also a victim of myocardial ischemia/reperfusion injury. Manifestations of such injury are increased vascular permeability and edema, endothelial dysfunction and impaired vasomotion, microembolization of atherothrombotic debris, stasis with intravascular cell aggregates, and finally, in its most severe form, capillary destruction with hemorrhage. In animal experiments, local and remote ischemic pre- and postconditioning not only reduce infarct size but also these manifestations of coronary vascular injury, as do drugs which recruit signal transduction steps of conditioning...
May 13, 2016: Circulation Research
A Sogorski, K Harati, N Kapalschinski, A Daigeler, T Hirsch, M Lehnhardt, O Goertz, J Kolbenschlag
Tissue perfusion is pivotal to wound healing and tissue regeneration after surgery. Ischemia and reperfusion lead to inflammatory reactions with consecutive tissue damage and necrosis. Multiple conditioning techniques have been described to protect tissue from those damaging mechanisms in the perioperative period. However, most of these fail to meet the requirements of a good therapeutic effect, time and cost efficiency, non-invasiveness and applicability without the need for additional devices or drugs. Remote ischemic conditioning (RIC) is a technique to provide endogenous tissue protection, which fully meets those requirements...
May 2, 2016: Zentralblatt Für Chirurgie
Juan J Alburquerque-Béjar, Ignasi Barba, Marisol Ruiz-Meana, Laura Valls-Lacalle, Antonio Rodríguez-Sinovas, David García-Dorado
No abstract text is available yet for this article.
June 2016: Revista Española de Cardiología
Ronson J Madathil, Ravi S Hira, Mathias Stoeckl, Fritz Sterz, JoAnn Broeckel Elrod, Graham Nichol
AIMS: We sought to review cellular changes that occur with reperfusion to try to understand whether ischemia-reperfusion injury (RI) is a potentially modifiable therapeutic target for cardioprotection or neuroprotection in patients undergoing cardiopulmonary resuscitation. DATA SOURCES: Articles written in English and published in PubMed. RESULTS: Remote ischemic conditioning (RIC) involves brief episodes of non-lethal ischemia and reperfusion applied to an organ or limb distal to the heart and brain...
August 2016: Resuscitation
Noriyuki Ouchi
Obesity, particularly excess visceral fat accumulation, is highly associated with the development of metabolic syndrome and atherosclerotic cardiovascular disease. Adipose tissue produces a variety of secreted proteins, referred to as adipocytokines, which directly affect nearby or remote organs. Dysregulation of adipocytokines caused by obese conditions contributes to the pathogenesis of various metabolic and cardiovascular disorders. This review focuses on the significance of several adipocytokines that potentially exert beneficial actions on obesity-related diseases, including atherosclerosis and ischemic heart disease...
June 1, 2016: Journal of Atherosclerosis and Thrombosis
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