Tamás Baranyai, Csilla Terézia Nagy, Gábor Koncsos, Zsófia Onódi, Melinda Károlyi-Szabó, András Makkos, Zoltán V Varga, Péter Ferdinandy, Zoltán Giricz
BACKGROUND: Remote ischemic perconditioning (RIPerC) has a promising therapeutic insight to improve the prognosis of acute myocardial infarction. Chronic comorbidities such as diabetes are known to interfere with conditioning interventions by modulating cardioprotective signaling pathways, such as e.g., mTOR pathway and autophagy. However, the effect of acute hyperglycemia on RIPerC has not been studied so far. Therefore, here we investigated the effect of acute hyperglycemia on cardioprotection by RIPerC...
November 18, 2015: Cardiovascular Diabetology