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https://www.readbyqxmd.com/read/29983617/alleviation-of-diabetic-complications-by-ginsenoside-rg3-enriched-red-ginseng-extract-in-western-diet-fed-ldl-mice
#1
Evelyn Saba, Seung-Hyung Kim, Sung-Dae Kim, Sang-Joon Park, Dongmi Kwak, Jun-Hwan Oh, Chae-Kyu Park, Man Hee Rhee
In this study, we precisely showed how the Rg3-enriched red ginseng extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL-/- mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red ginseng extract.
July 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29983616/a-proteomic-approach-reveals-the-differential-protein-expression-in-drosophila-melanogaster-treated-with-red-ginseng-extract-panax-ginseng
#2
Qing-Xiu Liu, Wei Zhang, Jia Wang, Wei Hou, Ying-Ping Wang
Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster . Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D...
July 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29982104/nrp-1-targeted-and-cargo-loaded-exosomes-facilitate-simultaneous-imaging-and-therapy-of-glioma-in-vitro-and-in-vivo
#3
Gang Jia, Yong Han, Yanli An, Yinan Ding, Chen He, Xihui Wang, Qiusha Tang
Currently, glioma treatment is limited by two main factors: timely detection at onset or relapse and restriction of drugs by the blood-brain barrier (BBB) from entering the brain and influencing tumor growth. However, a safe BBB-traversing drug delivery system has brought new hope to glioma treatment. Exosomes have strong cargo-loading capacity and have the ability to cross the BBB. They can also be conferred with the ability for targeted delivery. Therefore, exosomes have great promise to be a targeted drug delivery vehicles...
June 21, 2018: Biomaterials
https://www.readbyqxmd.com/read/29978338/father-absence-and-accelerated-reproductive-development-in-non-hispanic-white-women-in-the-united-states
#4
Lauren Gaydosh, Daniel W Belsky, Benjamin W Domingue, Jason D Boardman, Kathleen Mullan Harris
Girls who experience father absence in childhood also experience accelerated reproductive development in comparison with peers with present fathers. One hypothesis advanced to explain this empirical pattern is genetic confounding, wherein gene-environment correlation (rGE) causes a spurious relationship between father absence and reproductive timing. We test this hypothesis by constructing polygenic scores for age at menarche and first birth using recently available genome-wide association study results and molecular genetic data on a sample of non-Hispanic white females from the National Longitudinal Study of Adolescent to Adult Health...
July 5, 2018: Demography
https://www.readbyqxmd.com/read/29970815/effect-of-red-ginseng-extract-on-the-pharmacokinetics-and-efficacy-of-metformin-in-streptozotocin-induced-diabetic-rats
#5
So Jeong Nam, You Jin Han, Wonpyo Lee, Bitna Kang, Min-Koo Choi, Yong-Hae Han, Im-Sook Song
The purpose of this study was to investigate the effect of red ginseng extract on the pharmacokinetics (PK) and efficacy of metformin in streptozotocin-induced diabetic rats. The diabetes mellitus rat model was established by intraperitoneally administering multiple doses of streptozotocin (30 mg/kg, twice on day 1 and 8), and diabetic rats received metformin 50 mg/kg with or without single or multiple administration of Korean red ginseng extract (RGE, 2 g/kg/day, once or for 1 week). RGE administration did not affect the plasma concentration and renal excretion of metformin...
July 3, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29871617/gambling-expenditure-by-game-type-among-weekly-gamblers-in-finland
#6
Anne H Salonen, Jukka Kontto, Riku Perhoniemi, Hannu Alho, Sari Castrén
BACKGROUND: Excessive expenditure and financial harms are core features of problem gambling. There are various forms of gambling and their nature varies. The aim was to measure gambling expenditure by game type while controlling for demographics and other gambling participation factors. A further aim was to find out how each game type was associated with gambling expenditure when the number of game types played is adjusted for. METHODS: Using data from the 2015 Finnish Gambling survey on adult gamblers (n = 3555), multiple log-linear regression was used to examine the effects of demographics, gambling participation, and engaging in different game types on weekly gambling expenditure (WGE) and relative gambling expenditure (RGE)...
June 5, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29870552/genetic-abrogation-of-the-fibronectin-%C3%AE-5%C3%AE-1-integrin-interaction-in-articular-cartilage-aggravates-osteoarthritis-in-mice
#7
Maylin Almonte-Becerril, Irene Gimeno-LLuch, Olga Villarroya, María Benito-Jardón, Juan Bautista Kouri, Mercedes Costell
The balance between synthesis and degradation of the cartilage extracellular matrix is severely altered in osteoarthritis, where degradation predominates. One reason for this imbalance is believed to be due to the ligation of the α5β1 integrin, the classic fibronectin (FN) receptor, with soluble FN fragments instead of insoluble FN fibrils, which induces matrix metalloproteinase (MMP) expression. Our objective was to determine whether the lack of α5β1-FN binding influences cartilage morphogenesis in vivo and whether non-ligated α5β1 protects or aggravates the course of osteoarthritis in mice...
2018: PloS One
https://www.readbyqxmd.com/read/29760220/quantifying-atherogenic-lipoproteins-current-and-future-challenges-in-the-era-of-personalized-medicine-and-very-low-concentrations-of-ldl-cholesterol-a-consensus-statement-from-eas-and-eflm
#8
Michel R Langlois, M John Chapman, Christa Cobbaert, Samia Mora, Alan T Remaley, Emilio Ros, Gerald F Watts, Jan Borén, Hannsjörg Baum, Eric Bruckert, Alberico Catapano, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Genovefa Kolovou, Florian Kronenberg, Anne Langsted, Kari Pulkki, Nader Rifai, Grazyna Sypniewska, Olov Wiklund, Børge G Nordestgaard
BACKGROUND: The European Atherosclerosis Society-European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations to optimize atherogenic lipoprotein quantification for cardiovascular risk management. CONTENT: We critically examined LDL cholesterol, non-HDL cholesterol, apolipoprotein B (apoB), and LDL particle number assays based on key criteria for medical application of biomarkers. ( a ) Analytical performance: Discordant LDL cholesterol quantification occurs when LDL cholesterol is measured or calculated with different assays, especially in patients with hypertriglyceridemia >175 mg/dL (2 mmol/L) and low LDL cholesterol concentrations <70 mg/dL (1...
July 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29573494/limitations-of-steric-bulk-towards-phospha-germynes-and-phospha-stannynes
#9
Alexander Hinz, Jose M Goicoechea
The use of bulky aryl(silyl)amides (R) as substituents for the stabilisation of phospha-germynes and phospha-stannynes (R-Ge≡P and R-Sn≡P, respectively) is described. Such species can be transiently generated by photolysis of the phosphaketene precursors (RE(PCO); E=Ge, Sn). Utilisation of bulky amides R1 and R2 (R1 =Ar**NSi(OtBu)3 , where Ar**=2,6-bis[bis(4-tert-butylphenyl)methyl]-4-methylphenyl; R2 =Ar***NSi(iPr)3 , where Ar***=2,6-bis[bis(3,5-di-tert-butylphenyl)methyl]-4-methylphenyl) facilitates the formation of diphosphene-type dimers, [(RGe)P]2 and [(RSn)P]2 ...
May 23, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29528244/cell-penetrating-peptides-functionalized-gambogic-acid-nanostructured-lipid-carrier-for-cancer-treatment
#10
Rui Huang, Jiawei Li, Dereje Kebebe, Yumei Wu, Bing Zhang, Zhidong Liu
Tumor-targeted delivery is considered a crucial component of current anticancer drug development and is the best approach to increase the efficacy and reduce the toxicity. Nanomedicine, particularly ligand-based nanoparticles have shown a great potential for active targeting of tumor. Cell penetrating peptide is one of the promising ligands in a targeted cancer therapy. In this study, the gambogic acid-loaded nanostructured lipid carrier (GA-NLC) was modified with two kinds of cell penetrating peptides (cRGD and RGERPPR)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29490610/a-randomized-approach-to-speed-up-the-analysis-of-large-scale-read-count-data-in-the-application-of-cnv-detection
#11
WeiBo Wang, Wei Sun, Wei Wang, Jin Szatkiewicz
BACKGROUND: The application of high-throughput sequencing in a broad range of quantitative genomic assays (e.g., DNA-seq, ChIP-seq) has created a high demand for the analysis of large-scale read-count data. Typically, the genome is divided into tiling windows and windowed read-count data is generated for the entire genome from which genomic signals are detected (e.g. copy number changes in DNA-seq, enrichment peaks in ChIP-seq). For accurate analysis of read-count data, many state-of-the-art statistical methods use generalized linear models (GLM) coupled with the negative-binomial (NB) distribution by leveraging its ability for simultaneous bias correction and signal detection...
March 1, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29357343/long-term-clinical-effects-of-discogel-for-cervical-disc-herniation
#12
Havva Sayhan, Serbülent Gökhan Beyaz, Ali Metin Ülgen, Mehmet Fatih Yuce, Yakup Tomak
BACKGROUND: Radiopaque gelified ethanol (RGE; DiscoGel, Gelscom SAS, France) is used as a chemonucleolysis substance in treating intradiscal herniation, showing good results without complications. It has also been used in cervical disc herniations (CDHs), demonstrating the potential efficacy of this substance. OBJECTIVE: The aim of the study is to investigate the long-term effectiveness and safety of DiscoGel in patients with CDH and chronic neck pain. STUDY DESIGN: This is a cross-sectional, single-center study...
January 2018: Pain Physician
https://www.readbyqxmd.com/read/29290795/tumor-penetrating-peptide-conjugated-and-doxorubicin-loaded-t-1-t-2-dual-mode-mri-contrast-agents-nanoparticles-for-tumor-theranostics
#13
Lipeng Gao, Jing Yu, Yang Liu, Jinge Zhou, Lei Sun, Jing Wang, Jianzhong Zhu, Hui Peng, Weiyue Lu, Lei Yu, Zhiqiang Yan, Yiting Wang
The conventional chemotherapeutics could not be traced in vivo and provide timely feedback on the clinical effectiveness of drugs. Methods: In this study, a tumor-penetrating peptide RGERPPR (RGE) modified, Gd-DTPA conjugated, and doxorubicin (DOX) loaded Fe3 O4 @SiO2 @mSiO2 nanoparticle drug delivery system (Fe3 O4 @SiO2 @mSiO2 /DOX-(Gd-DTPA)-PEG-RGE NPs) was prepared for tumor theranostics. Results: The Fe3 O4 @SiO2 @mSiO2 /DOX-(Gd-DTPA)-PEG-RGE NPs showed a z-average hydrodynamic diameter of about 90 nm, and a pH-sensitive DOX release profile...
2018: Theranostics
https://www.readbyqxmd.com/read/29274665/red-ginseng-extracts-attenuate-skin-inflammation-in-atopic-dermatitis-through-p70-ribosomal-protein-s6-kinase-activation
#14
Mayuko Osada-Oka, Sayaka Hirai, Yasukatsu Izumi, Kazuhiro Misumi, Keiichi Samukawa, Shuhei Tomita, Katsuyuki Miura, Yukiko Minamiyama, Hiroshi Iwao
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease with increased immunoglobulin E (IgE) levels. Activation of the mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) signaling is known to occur in the inflammatory regions of AD skin. We previously demonstrated that red ginseng extract (RGE), as an anti-inflammatory agent, had potential for treating AD. However, it is still unclear whether RGE inhibits mTOR/p70S6K signaling. Thus, we examined the anti-inflammatory effects of RGE on IgE or interferon-γ (IFN-γ) induced signaling pathways...
January 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29122178/pdslt2-penicillium-digitatum-mitogen-activated-protein-kinase-controls-sporulation-and-virulence-during-citrus-fruit-infection
#15
Marta de Ramón-Carbonell, Paloma Sánchez-Torres
The Slt2 mitogen-activated protein (MAP) kinase homologue of Penicillium digitatum, the most relevant pathogen-producing citrus green mould decay during postharvest, was identified and explored. The P. digitatum Slt2-MAPK coding gene (PdSlt2) was functionally characterized by homologous gene elimination and transcriptomic evaluation. The absence of PdSlt2 gene resulted in significantly reduced virulence during citrus infection. The ΔPdSlt2 mutants were also defective in asexual reproduction, showing impairment of sporulation during citrus infection...
December 2017: Fungal Biology
https://www.readbyqxmd.com/read/29021703/ginsenoside-rg3-enriched-red-ginseng-extract-inhibits-platelet-activation-and-in-vivo-thrombus-formation
#16
Dahye Jeong, Muhammad Irfan, Sung-Dae Kim, Suk Kim, Jun-Hwan Oh, Chae-Kyu Park, Hyun-Kyoung Kim, Man Hee Rhee
BACKGROUND: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from red ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021698/nonsaponin-fractions-of-korean-red-ginseng-extracts-prime-activation-of-nlrp3-inflammasome
#17
Byung-Cheol Han, Huijeong Ahn, Jiseon Lee, Eunsaem Jeon, Sanghoon Seo, Kyoung Hwa Jang, Seung-Ho Lee, Cheon Ho Kim, Geun-Shik Lee
BACKGROUND: Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. METHODS: To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF)...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28968068/self-assembled-tumor-penetrating-peptide-modified-poly-l-%C3%AE-glutamylglutamine-paclitaxel-nanoparticles-based-on-hydrophobic-interaction-for-the-treatment-of-glioblastoma
#18
Jing Yu, Lei Sun, Jinge Zhou, Lipeng Gao, Lijuan Nan, Shimin Zhao, Ting Peng, Lin Han, Jing Wang, Weiyue Lu, Lin Zhang, Yiting Wang, Zhiqiang Yan, Lei Yu
To enhance the tumor-penetrating ability and targeting therapeutic effect of polymer-drug conjugates (PDCs), tumor-penetrating peptide RGERPPR (RGE) modified and PEGylated poly(l-γ-glutamylglutamine)-paclitaxel (PGG-PTX) nanoparticles (RGE-PEG/PGG-PTX NPs) were prepared by using a so-called "modular" design strategy. In brief, a RGERPPR-conjugated targeting material, DSPE-PEG-RGERPPR, was first synthesized and assembled with PGG-PTX into RGE-PEG/PGG-PTX NPs based on the hydrophobic interaction between the groups of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and PTX...
November 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28965342/factors-of-rowing-ergometer-performance-in-high-level-female-rowers
#19
COMPARATIVE STUDY
Muriel Bourdin, Jean-Rene Lacour, Charles Imbert, Laurent André Messonnier
The present study investigated morphological and physiological factors of rowing ergometer performance over 2000 m (P2000, W) in 70 national and international level [27 lightweight (LW) and 43 heavyweight (HW)] female rowers. Maximal oxygen uptake (V̇O2max , L.min-1 ), maximal aerobic power (Pamax , W), power output corresponding to 4 mmol.L-1 blood lactate concentration expressed in absolute (PLa4 , W) and relative to Pamax (PLa4 %, %) values, peak power output (Ppeak , W), and rowing gross efficiency (RGE, %) were determined during an incremental rowing test...
November 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28876522/roles-of-response-inhibition-and-gene-environment-interplay-in-pathways-to-adolescents-externalizing-problems
#20
Frances L Wang, Laurie Chassin, Matthew Lee, Moira Haller, Kevin King
This study used two waves of data to investigate pathways through which adolescents' response inhibition related to later externalizing problems. A polygenic risk score indexed genetic risk for poor response inhibition. Adolescents' performance on a response inhibition task mediated the relation between adolescents' polygenic risk scores and mother's inconsistent parenting (i.e., evocative rGE), even after controlling for mothers' genetic risk (i.e., passive rGE). Mothers' inconsistent parenting subsequently prospectively predicted adolescents' externalizing problems...
June 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
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