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https://www.readbyqxmd.com/read/30424502/effects-of-red-ginseng-extract-on-the-pharmacokinetics-and-elimination-of-methotrexate-via-mrp2-regulation
#1
Sowon Lee, Mihwa Kwon, Min-Koo Choi, Im-Sook Song
We aimed to investigate the effects of red ginseng extract (RGE) on the expression of efflux transporters and to study the pharmacokinetics of representative substrate. For this, rats received single or repeated administration of RGE (1.5 g/kg/day) for 1 and 2 weeks via oral gavage. mRNA and protein levels of multidrug resistance-associated protein2 (Mrp2), bile salt export pump (Bsep), and P-glycoprotein (P-gp) in the rat liver were measured via real-time polymerase chain reaction and Western blot analysis...
November 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30405742/anti-inflammatory-activity-of-rg3-enriched-korean-red-ginseng-extract-in-murine-model-of-sepsis
#2
Evelyn Saba, Dahye Jeong, Muhammad Irfan, Yuan Yee Lee, Sang-Joon Park, Chae-Kyu Park, Man Hee Rhee
Ginseng has therapeutic effects on various bodily disorders ranging from minor inflammation to major cardiovascular diseases. In our study, we explored the anti-inflammatory effects of Rg3-enriched red ginseng extract (Rg3-RGE), a ginsenoside belonging to the panaxadiol group. We employed nitric oxide assay (NO) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), western blot, and hematoxylin and eosin staining (H&E) to elucidate the anti-inflammatory activity of Rg3-RGE...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30376071/triple-combination-of-meropenem-colistin-and-tigecycline-was-bactericidal-in-a-dynamic-model-despite-mere-additive-interactions-in-chequerboard-assays-against-carbapenemase-producing-klebsiella-pneumoniae-isolates
#3
Marilena Tsala, Sophia Vourli, Panagiota-Christina Georgiou, Spyros Pournaras, Ge Rge L Daikos, Johan W Mouton, Joseph Meletiadis
Background: Combination schemes are commonly used for the treatment of infections due to carbapenemase-producing Klebsiella pneumoniae (CP-Kp). We therefore investigated the in vitro effectiveness of double and triple combinations of meropenem, colistin and tigecycline against CP-Kp isolates with different resistance mechanisms in a static broth microdilution model and a pharmacokinetic-pharmacodynamic model. Methods: One WT isolate and seven CP-Kp isolates with different carbapenem resistance mechanisms and increasing MICs of meropenem (4-512 mg/L), colistin (0...
October 30, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/30344431/a-comparative-study-on-immune-stimulatory-and-antioxidant-activities-of-various-types-of-ginseng-extracts-in-murine-and-rodent-models
#4
Evelyn Saba, Yuan Yee Lee, Minki Kim, Seung-Hyung Kim, Seung-Bok Hong, Man Hee Rhee
Background: Ginseng ( Panax ginseng ) is a widely used traditional herbal supplement that possesses various health-enhancing efficacies. Various ginseng products are available in market, especially in the Korean peninsula, in the form of drinks, tablets, and capsules. The different ginseng types include the traditional red ginseng extract (RGE), white ginseng, and black red ginseng extract (BRGE). Their fermented and enzyme-treated products are also available. Different treatment regimens alter the bioavailability of certain compounds present in the respective ginseng extracts...
October 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/30335430/attained-ses-as-a-moderator-of-adult-cognitive-performance-testing-gene-environment-interaction-in-various-cognitive-domains
#5
Catalina Zavala, Christopher R Beam, Brian K Finch, Margaret Gatz, Wendy Johnson, William S Kremen, Jenae M Neiderhiser, Nancy L Pedersen, Chandra A Reynolds
We examined whether attained socioeconomic status (SES) moderated genetic and environmental sources of individual differences in cognitive performance using pooled data from 9 adult twin studies. Prior work concerning SES moderation of cognitive performance has focused on rearing SES. The current adult sample of 12,196 individuals (aged 27-98 years) allowed for the examination of common sources of individual differences between attained SES and cognitive performance (signaling potential gene-environment correlation mechanisms, rGE), as well as sources of individual differences unique to cognitive performance (signaling potential gene-environment interaction mechanisms, G × E)...
October 18, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/30306994/designed-single-source-precursors-for-iron-germanide-nanoparticles-colloidal-synthesis-and-magnetic-properties
#6
Alexandre Sodreau, Sonia Mallet-Ladeira, Sebastien Lachaize, Karinne Miqueu, Jean-Marc Sotiropoulos, David Madec, Céline Nayral, Fabien Delpech
The synthesis of iron germanide nanoparticles at the nanoscale is a challenging task. Here, we describe the preparation of nanocrystals of the hexagonal Fe1.67Ge phase via the thermolysis of single source precursors [{iPrNC(tBu)NiPr}RGe]Fe(CO)4 (where R = Cl, N(SiMe3)2) under mild conditions (200 °C). These bimetallic precursors and the corresponding germylenes [{iPrNC(tBu)NiPr}RGe] were fully characterized by spectroscopic techniques as well as single crystal X-ray diffraction. While the structural features of the molecular species were shown to be almost identical, the results of the thermolysis were highly dependent on the nature of R...
October 30, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/30256042/fibronectin-regulates-the-dynamic-formation-of-ovarian-cancer-multicellular-aggregates-and-the-expression-of-integrin-receptors
#7
Lin Gong, Ying Zheng, Shanling Liu, Zhilan Peng
Objective: To investigate the regulatory role of fibronectin (FN) in the formation of multicellular aggregate (MCA) in ovarian cancer SKOV3 and OVCAR-3 cells and integrin expression. Methods: The dynamic formation of MCA in SKOV3 and OVCAR-3 was determined using the liquid overlay technique in the presence or absence of FN, anti-FN, RGD peptide, control RGE. The expression of α3β1, α4β1 and α5β1 integrin in monolayer cells, MCA and FN-treated MCA were determined by flow cytometry and quantitative RT-PCR...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/30168407/polygenic-risk-family-cohesion-and-adolescent-aggression-in-mexican-american-and-european-american-families-developmental-pathways-to-alcohol-use
#8
Kit K Elam, Laurie Chassin, Danielle Pandika
Poor family cohesion and elevated adolescent aggression are associated with greater alcohol use in adolescence and early adulthood. In addition, evocative gene-environment correlations (rGEs) can underlie the interplay between offspring characteristics and negative family functioning, contributing to substance use. Gene-environment interplay has rarely been examined in racial/ethnic minority populations. The current study examined adolescents' polygenic risk scores for aggression in evocative rGEs underlying aggression and family cohesion during adolescence, their contributions to alcohol use in early adulthood (n = 479), and differences between Mexican American and European American subsamples...
August 31, 2018: Development and Psychopathology
https://www.readbyqxmd.com/read/30027862/gene-environment-correlations-affecting-children-s-early-rule-breaking-and-aggressive-play-behaviors
#9
Lisabeth F DiLalla, David L DiLalla
Play among peers is an important developmental context for child socialization. We have earlier shown that children at genetic risk for aggression were more likely to be treated aggressively by unfamiliar peers during peer play, reflecting genotype-evoked behaviors manifested during play. In this study, 118 5-year-old twin pairs were paired randomly with an unfamiliar, same-age, same-sex child, thus controlling for parent- and child-chosen environments (passive and active rGE). Twins played separately from each other with unmatched children...
August 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29983617/alleviation-of-diabetic-complications-by-ginsenoside-rg3-enriched-red-ginseng-extract-in-western-diet-fed-ldl-mice
#10
Evelyn Saba, Seung-Hyung Kim, Sung-Dae Kim, Sang-Joon Park, Dongmi Kwak, Jun-Hwan Oh, Chae-Kyu Park, Man Hee Rhee
In this study, we precisely showed how the Rg3-enriched red ginseng extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL-/- mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red ginseng extract.
July 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29983616/a-proteomic-approach-reveals-the-differential-protein-expression-in-drosophila-melanogaster-treated-with-red-ginseng-extract-panax-ginseng
#11
Qing-Xiu Liu, Wei Zhang, Jia Wang, Wei Hou, Ying-Ping Wang
Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster . Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D...
July 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29982104/nrp-1-targeted-and-cargo-loaded-exosomes-facilitate-simultaneous-imaging-and-therapy-of-glioma-in-vitro-and-in-vivo
#12
Gang Jia, Yong Han, Yanli An, Yinan Ding, Chen He, Xihui Wang, Qiusha Tang
Currently, glioma treatment is limited by two main factors: timely detection at onset or relapse and restriction of drugs by the blood-brain barrier (BBB) from entering the brain and influencing tumor growth. However, a safe BBB-traversing drug delivery system has brought new hope to glioma treatment. Exosomes have strong cargo-loading capacity and have the ability to cross the BBB. They can also be conferred with the ability for targeted delivery. Therefore, exosomes have great promise to be a targeted drug delivery vehicles...
September 2018: Biomaterials
https://www.readbyqxmd.com/read/29978338/father-absence-and-accelerated-reproductive-development-in-non-hispanic-white-women-in-the-united-states
#13
Lauren Gaydosh, Daniel W Belsky, Benjamin W Domingue, Jason D Boardman, Kathleen Mullan Harris
Girls who experience father absence in childhood also experience accelerated reproductive development in comparison with peers with present fathers. One hypothesis advanced to explain this empirical pattern is genetic confounding, wherein gene-environment correlation (rGE) causes a spurious relationship between father absence and reproductive timing. We test this hypothesis by constructing polygenic scores for age at menarche and first birth using recently available genome-wide association study results and molecular genetic data on a sample of non-Hispanic white females from the National Longitudinal Study of Adolescent to Adult Health...
August 2018: Demography
https://www.readbyqxmd.com/read/29970815/effect-of-red-ginseng-extract-on-the-pharmacokinetics-and-efficacy-of-metformin-in-streptozotocin-induced-diabetic-rats
#14
So Jeong Nam, You Jin Han, Wonpyo Lee, Bitna Kang, Min-Koo Choi, Yong-Hae Han, Im-Sook Song
The purpose of this study was to investigate the effect of red ginseng extract on the pharmacokinetics (PK) and efficacy of metformin in streptozotocin-induced diabetic rats. The diabetes mellitus rat model was established by intraperitoneally administering multiple doses of streptozotocin (30 mg/kg, twice on day 1 and 8), and diabetic rats received metformin 50 mg/kg with or without single or multiple administration of Korean red ginseng extract (RGE, 2 g/kg/day, once or for 1 week). RGE administration did not affect the plasma concentration and renal excretion of metformin...
July 3, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29871617/gambling-expenditure-by-game-type-among-weekly-gamblers-in-finland
#15
Anne H Salonen, Jukka Kontto, Riku Perhoniemi, Hannu Alho, Sari Castrén
BACKGROUND: Excessive expenditure and financial harms are core features of problem gambling. There are various forms of gambling and their nature varies. The aim was to measure gambling expenditure by game type while controlling for demographics and other gambling participation factors. A further aim was to find out how each game type was associated with gambling expenditure when the number of game types played is adjusted for. METHODS: Using data from the 2015 Finnish Gambling survey on adult gamblers (n = 3555), multiple log-linear regression was used to examine the effects of demographics, gambling participation, and engaging in different game types on weekly gambling expenditure (WGE) and relative gambling expenditure (RGE)...
June 5, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29870552/genetic-abrogation-of-the-fibronectin-%C3%AE-5%C3%AE-1-integrin-interaction-in-articular-cartilage-aggravates-osteoarthritis-in-mice
#16
Maylin Almonte-Becerril, Irene Gimeno-LLuch, Olga Villarroya, María Benito-Jardón, Juan Bautista Kouri, Mercedes Costell
The balance between synthesis and degradation of the cartilage extracellular matrix is severely altered in osteoarthritis, where degradation predominates. One reason for this imbalance is believed to be due to the ligation of the α5β1 integrin, the classic fibronectin (FN) receptor, with soluble FN fragments instead of insoluble FN fibrils, which induces matrix metalloproteinase (MMP) expression. Our objective was to determine whether the lack of α5β1-FN binding influences cartilage morphogenesis in vivo and whether non-ligated α5β1 protects or aggravates the course of osteoarthritis in mice...
2018: PloS One
https://www.readbyqxmd.com/read/29760220/quantifying-atherogenic-lipoproteins-current-and-future-challenges-in-the-era-of-personalized-medicine-and-very-low-concentrations-of-ldl-cholesterol-a-consensus-statement-from-eas-and-eflm
#17
Michel R Langlois, M John Chapman, Christa Cobbaert, Samia Mora, Alan T Remaley, Emilio Ros, Gerald F Watts, Jan Borén, Hannsjörg Baum, Eric Bruckert, Alberico Catapano, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Genovefa Kolovou, Florian Kronenberg, Anne Langsted, Kari Pulkki, Nader Rifai, Grazyna Sypniewska, Olov Wiklund, Børge G Nordestgaard
BACKGROUND: The European Atherosclerosis Society-European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations to optimize atherogenic lipoprotein quantification for cardiovascular risk management. CONTENT: We critically examined LDL cholesterol, non-HDL cholesterol, apolipoprotein B (apoB), and LDL particle number assays based on key criteria for medical application of biomarkers. ( a ) Analytical performance: Discordant LDL cholesterol quantification occurs when LDL cholesterol is measured or calculated with different assays, especially in patients with hypertriglyceridemia >175 mg/dL (2 mmol/L) and low LDL cholesterol concentrations <70 mg/dL (1...
July 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29573494/limitations-of-steric-bulk-towards-phospha-germynes-and-phospha-stannynes
#18
Alexander Hinz, Jose M Goicoechea
The use of bulky aryl(silyl)amides (R) as substituents for the stabilisation of phospha-germynes and phospha-stannynes (R-Ge≡P and R-Sn≡P, respectively) is described. Such species can be transiently generated by photolysis of the phosphaketene precursors (RE(PCO); E=Ge, Sn). Utilisation of bulky amides R1 and R2 (R1 =Ar**NSi(OtBu)3 , where Ar**=2,6-bis[bis(4-tert-butylphenyl)methyl]-4-methylphenyl; R2 =Ar***NSi(iPr)3 , where Ar***=2,6-bis[bis(3,5-di-tert-butylphenyl)methyl]-4-methylphenyl) facilitates the formation of diphosphene-type dimers, [(RGe)P]2 and [(RSn)P]2 ...
May 23, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29528244/cell-penetrating-peptides-functionalized-gambogic-acid-nanostructured-lipid-carrier-for-cancer-treatment
#19
COMPARATIVE STUDY
Rui Huang, Jiawei Li, Dereje Kebebe, Yumei Wu, Bing Zhang, Zhidong Liu
Tumor-targeted delivery is considered a crucial component of current anticancer drug development and is the best approach to increase the efficacy and reduce the toxicity. Nanomedicine, particularly ligand-based nanoparticles have shown a great potential for active targeting of tumor. Cell penetrating peptide is one of the promising ligands in a targeted cancer therapy. In this study, the gambogic acid-loaded nanostructured lipid carrier (GA-NLC) was modified with two kinds of cell penetrating peptides (cRGD and RGERPPR)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29490610/a-randomized-approach-to-speed-up-the-analysis-of-large-scale-read-count-data-in-the-application-of-cnv-detection
#20
WeiBo Wang, Wei Sun, Wei Wang, Jin Szatkiewicz
BACKGROUND: The application of high-throughput sequencing in a broad range of quantitative genomic assays (e.g., DNA-seq, ChIP-seq) has created a high demand for the analysis of large-scale read-count data. Typically, the genome is divided into tiling windows and windowed read-count data is generated for the entire genome from which genomic signals are detected (e.g. copy number changes in DNA-seq, enrichment peaks in ChIP-seq). For accurate analysis of read-count data, many state-of-the-art statistical methods use generalized linear models (GLM) coupled with the negative-binomial (NB) distribution by leveraging its ability for simultaneous bias correction and signal detection...
March 1, 2018: BMC Bioinformatics
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