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https://www.readbyqxmd.com/read/29760220/quantifying-atherogenic-lipoproteins-current-and-future-challenges-in-the-era-of-personalized-medicine-and-vldl-cholesterol-a-consensus-statement-from-eas-and-eflm
#1
Michel R Langlois, M John Chapman, Christa Cobbaert, Samia Mora, Alan T Remaley, Emilio Ros, Gerald F Watts, Jan Borén, Hannsjörg Baum, Eric Bruckert, Alberico Catapano, Olivier S Descamps, Arnold von Eckardstein, Pia R Kamstrup, Genovefa Kolovou, Florian Kronenberg, Anne Langsted, Kari Pulkki, Nader Rifai, Grazyna Sypniewska, Olov Wiklund, B Rge G Nordestgaard
BACKGROUND: The European Atherosclerosis Society-European Federation of Clinical Chemistry and Laboratory Medicine Consensus Panel aims to provide recommendations to optimize atherogenic lipoprotein quantification for cardiovascular risk management. CONTENT: We critically examined LDL cholesterol, non-HDL cholesterol, apolipoprotein B (apoB), and LDL particle number assays based on key criteria for medical application of biomarkers. ( a ) Analytical performance: Discordant LDL cholesterol quantification occurs when LDL cholesterol is measured or calculated with different assays, especially in patients with hypertriglyceridemia >175 mg/dL (2 mmol/L) and low LDL cholesterol concentrations <70 mg/dL (1...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29573494/limitations-of-steric-bulk-towards-phospha-germynes-and-phospha-stannynes
#2
Alexander Hinz, Jose Manuel Goicoechea
The use of bulky aryl(silyl)amides (R) as substituents for the stabilisation of phospha-germynes and phospha-stannynes (R-Ge≡P and R-Sn≡P, respectively) is described. Such species can be transiently generated by photolysis of the phosphaketene precursors (RE(PCO); E = Ge, Sn). Utilisation of bulky amides R1 and R2 (R1 = Ar**NSi(OtBu)3, where Ar** = 2,6-bis[bis(4-tert-butylphenyl)methyl]-4-methylphenyl; R2 = Ar***NSi(iPr)3, where Ar*** = 2,6-bis[bis(3,5-ditert-butylphenyl)methyl]-4-methyl¬phenyl) facilitates the formation of diphosphene-type dimers, [(RSn)P]2 and [(RGe)P]2...
March 24, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29528244/cell-penetrating-peptides-functionalized-gambogic-acid-nanostructured-lipid-carrier-for-cancer-treatment
#3
Rui Huang, Jiawei Li, Dereje Kebebe, Yumei Wu, Bing Zhang, Zhidong Liu
Tumor-targeted delivery is considered a crucial component of current anticancer drug development and is the best approach to increase the efficacy and reduce the toxicity. Nanomedicine, particularly ligand-based nanoparticles have shown a great potential for active targeting of tumor. Cell penetrating peptide is one of the promising ligands in a targeted cancer therapy. In this study, the gambogic acid-loaded nanostructured lipid carrier (GA-NLC) was modified with two kinds of cell penetrating peptides (cRGD and RGERPPR)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29490610/a-randomized-approach-to-speed-up-the-analysis-of-large-scale-read-count-data-in-the-application-of-cnv-detection
#4
WeiBo Wang, Wei Sun, Wei Wang, Jin Szatkiewicz
BACKGROUND: The application of high-throughput sequencing in a broad range of quantitative genomic assays (e.g., DNA-seq, ChIP-seq) has created a high demand for the analysis of large-scale read-count data. Typically, the genome is divided into tiling windows and windowed read-count data is generated for the entire genome from which genomic signals are detected (e.g. copy number changes in DNA-seq, enrichment peaks in ChIP-seq). For accurate analysis of read-count data, many state-of-the-art statistical methods use generalized linear models (GLM) coupled with the negative-binomial (NB) distribution by leveraging its ability for simultaneous bias correction and signal detection...
March 1, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29357343/long-term-clinical-effects-of-discogel-for-cervical-disc-herniation
#5
Havva Sayhan, Serbülent Gökhan Beyaz, Ali Metin Ülgen, Mehmet Fatih Yuce, Yakup Tomak
BACKGROUND: Radiopaque gelified ethanol (RGE; DiscoGel, Gelscom SAS, France) is used as a chemonucleolysis substance in treating intradiscal herniation, showing good results without complications. It has also been used in cervical disc herniations (CDHs), demonstrating the potential efficacy of this substance. OBJECTIVE: The aim of the study is to investigate the long-term effectiveness and safety of DiscoGel in patients with CDH and chronic neck pain. STUDY DESIGN: This is a cross-sectional, single-center study...
January 2018: Pain Physician
https://www.readbyqxmd.com/read/29290795/tumor-penetrating-peptide-conjugated-and-doxorubicin-loaded-t-1-t-2-dual-mode-mri-contrast-agents-nanoparticles-for-tumor-theranostics
#6
Lipeng Gao, Jing Yu, Yang Liu, Jinge Zhou, Lei Sun, Jing Wang, Jianzhong Zhu, Hui Peng, Weiyue Lu, Lei Yu, Zhiqiang Yan, Yiting Wang
The conventional chemotherapeutics could not be traced in vivo and provide timely feedback on the clinical effectiveness of drugs. Methods: In this study, a tumor-penetrating peptide RGERPPR (RGE) modified, Gd-DTPA conjugated, and doxorubicin (DOX) loaded Fe3 O4 @SiO2 @mSiO2 nanoparticle drug delivery system (Fe3 O4 @SiO2 @mSiO2 /DOX-(Gd-DTPA)-PEG-RGE NPs) was prepared for tumor theranostics. Results: The Fe3 O4 @SiO2 @mSiO2 /DOX-(Gd-DTPA)-PEG-RGE NPs showed a z-average hydrodynamic diameter of about 90 nm, and a pH-sensitive DOX release profile...
2018: Theranostics
https://www.readbyqxmd.com/read/29274665/red-ginseng-extracts-attenuate-skin-inflammation-in-atopic-dermatitis-through-p70-ribosomal-protein-s6-kinase-activation
#7
Mayuko Osada-Oka, Sayaka Hirai, Yasukatsu Izumi, Kazuhiro Misumi, Keiichi Samukawa, Shuhei Tomita, Katsuyuki Miura, Yukiko Minamiyama, Hiroshi Iwao
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease with increased immunoglobulin E (IgE) levels. Activation of the mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase (p70S6K) signaling is known to occur in the inflammatory regions of AD skin. We previously demonstrated that red ginseng extract (RGE), as an anti-inflammatory agent, had potential for treating AD. However, it is still unclear whether RGE inhibits mTOR/p70S6K signaling. Thus, we examined the anti-inflammatory effects of RGE on IgE or interferon-γ (IFN-γ) induced signaling pathways...
January 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29122178/pdslt2-penicillium-digitatum-mitogen-activated-protein-kinase-controls-sporulation-and-virulence-during-citrus-fruit-infection
#8
Marta de Ramón-Carbonell, Paloma Sánchez-Torres
The Slt2 mitogen-activated protein (MAP) kinase homologue of Penicillium digitatum, the most relevant pathogen-producing citrus green mould decay during postharvest, was identified and explored. The P. digitatum Slt2-MAPK coding gene (PdSlt2) was functionally characterized by homologous gene elimination and transcriptomic evaluation. The absence of PdSlt2 gene resulted in significantly reduced virulence during citrus infection. The ΔPdSlt2 mutants were also defective in asexual reproduction, showing impairment of sporulation during citrus infection...
December 2017: Fungal Biology
https://www.readbyqxmd.com/read/29021703/ginsenoside-rg3-enriched-red-ginseng-extract-inhibits-platelet-activation-and-in-vivo-thrombus-formation
#9
Dahye Jeong, Muhammad Irfan, Sung-Dae Kim, Suk Kim, Jun-Hwan Oh, Chae-Kyu Park, Hyun-Kyoung Kim, Man Hee Rhee
BACKGROUND: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from red ginseng, has been shown to have antiplatelet activity in addition to its anticancer and anti-inflammatory activities...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29021698/nonsaponin-fractions-of-korean-red-ginseng-extracts-prime-activation-of-nlrp3-inflammasome
#10
Byung-Cheol Han, Huijeong Ahn, Jiseon Lee, Eunsaem Jeon, Sanghoon Seo, Kyoung Hwa Jang, Seung-Ho Lee, Cheon Ho Kim, Geun-Shik Lee
BACKGROUND: Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of nonsaponin components of RGE have not been well studied. METHODS: To assess the roles of nonsaponin fractions (NS) in NLRP3 inflammasome activation, we treated murine macrophages with or without first or second inflammasome activation signals with RGE, NS, or saponin fractions (SF)...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28968068/self-assembled-tumor-penetrating-peptide-modified-poly-l-%C3%AE-glutamylglutamine-paclitaxel-nanoparticles-based-on-hydrophobic-interaction-for-the-treatment-of-glioblastoma
#11
Jing Yu, Lei Sun, Jinge Zhou, Lipeng Gao, Lijuan Nan, Shimin Zhao, Ting Peng, Lin Han, Jing Wang, Weiyue Lu, Lin Zhang, Yiting Wang, Zhiqiang Yan, Lei Yu
To enhance the tumor-penetrating ability and targeting therapeutic effect of polymer-drug conjugates (PDCs), tumor-penetrating peptide RGERPPR (RGE) modified and PEGylated poly(l-γ-glutamylglutamine)-paclitaxel (PGG-PTX) nanoparticles (RGE-PEG/PGG-PTX NPs) were prepared by using a so-called "modular" design strategy. In brief, a RGERPPR-conjugated targeting material, DSPE-PEG-RGERPPR, was first synthesized and assembled with PGG-PTX into RGE-PEG/PGG-PTX NPs based on the hydrophobic interaction between the groups of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and PTX...
November 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28965342/factors-of-rowing-ergometer-performance-in-high-level-female-rowers
#12
COMPARATIVE STUDY
Muriel Bourdin, Jean-Rene Lacour, Charles Imbert, Laurent André Messonnier
The present study investigated morphological and physiological factors of rowing ergometer performance over 2000 m (P2000, W) in 70 national and international level [27 lightweight (LW) and 43 heavyweight (HW)] female rowers. Maximal oxygen uptake (V̇O2max , L.min-1 ), maximal aerobic power (Pamax , W), power output corresponding to 4 mmol.L-1 blood lactate concentration expressed in absolute (PLa4 , W) and relative to Pamax (PLa4 %, %) values, peak power output (Ppeak , W), and rowing gross efficiency (RGE, %) were determined during an incremental rowing test...
November 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28876522/roles-of-response-inhibition-and-gene-environment-interplay-in-pathways-to-adolescents-externalizing-problems
#13
Frances L Wang, Laurie Chassin, Matthew Lee, Moira Haller, Kevin King
This study used two waves of data to investigate pathways through which adolescents' response inhibition related to later externalizing problems. A polygenic risk score indexed genetic risk for poor response inhibition. Adolescents' performance on a response inhibition task mediated the relation between adolescents' polygenic risk scores and mother's inconsistent parenting (i.e., evocative rGE), even after controlling for mothers' genetic risk (i.e., passive rGE). Mothers' inconsistent parenting subsequently prospectively predicted adolescents' externalizing problems...
June 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28836489/postdose-3-g1-serum-neutralizing-antibody-as-correlate-of-protection-for-pentavalent-rotavirus-vaccine
#14
G Frank Liu, Darcy Hille, Susan S Kaplan, Michelle G Goveia
Although clinical trials of the pentavalent rotavirus vaccine (RotaTeq®, RV5) have demonstrated efficacy against RV gastroenteritis (RGE) in low and high-income settings, a clear correlate of protection or a measure of immune response that could predict efficacy has yet to be identified. This is the first time that immunogenicity data with both serum neutralized antibody (SNA) titers and anti-RV IgA titers from several clinical efficacy trials were pooled to provide a unique context for evaluating the correlation between immunogenicity and RGE risk or efficacy of RV5...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28835374/low-affinity-binding-in-cis-to-p2y-2-r-mediates-force-dependent-integrin-activation-during-hantavirus-infection
#15
Virginie Bondu, Chenyu Wu, Wenpeng Cao, Peter C Simons, Jennifer Gillette, Jieqing Zhu, Laurie Erb, X Frank Zhang, Tione Buranda
Pathogenic hantaviruses bind to the plexin-semaphorin-integrin (PSI) domain of inactive, β3 integrins. Previous studies have implicated a cognate cis interaction between the bent conformation β5 /β3 integrins and an arginine-glycine-aspartic acid (RGD) sequence in the first extracellular loop of P2Y2 R. With single-molecule atomic force microscopy, we show a specific interaction between an atomic force microscopy tip decorated with recombinant αIIb β3 integrins and (RGD)P2Y2 R expressed on cell membranes...
October 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28828029/oral-administration-of-red-ginseng-extract-promotes-neurorestoration-after-compressive-spinal-cord-injury-in-rats
#16
Pengxiang Zhu, Keiichi Samukawa, Hiroko Fujita, Hidemasa Kato, Masahiro Sakanaka
Red ginseng and its active ingredients have been shown to decrease neuron death after brain ischemia in experimental animals. However, little is known about the effects of orally administered ginseng extract on spinal cord injury. We orally gave red ginseng extract (RGE) to rats with compressed spinal cord injury (SCI). Open-field locomotor scores were measured as indices of motor function. Histopathological changes and cytokine expressions in situ after SCI were evaluated. Compared to vehicle treatment, RGE treatment (350 mg/kg/day) significantly improved locomotor score up to levels close to those pre-SCI, prevented neuron loss, and facilitated the restoration of white matter in the spinal cord at 14 days after SCI...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28686294/nfat-regulated-cytokine-gene-expression-during-tacrolimus-therapy-early-after-renal-transplantation
#17
Sara Bremer, Nils T Vethe, Morten Skauby, Margrete Kasbo, Elisabet D Johansson, Karsten Midtvedt, Stein Bergan
AIMS: Despite pharmacokinetic monitoring of calcineurin inhibitors, the long-term outcome after transplantation (Tx) is still hampered by the side effects of these drugs. The aim of the present study was to characterize nuclear factor of activated T cells (NFAT)-regulated gene expression as a potential pharmacodynamic biomarker for further individualization of tacrolimus (Tac) therapy. METHODS: In 29 renal allograft recipients, samples were drawn once pre-Tx, and before and 1...
November 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28659175/allergens-in-red-ginseng-extract-induce-the-release-of-mediators-associated-with-anaphylactoid-reactions
#18
Lu Wang, Yazheng Zhao, Ye Yang, Yuanjia Hu, Xiaohan Zou, Boyang Yu, Jin Qi
BACKGROUND: Anaphylactoid reactions induced by preparations containing red ginseng have been reported. The aim of this study is to evaluate the allergenicity and screen potential allergens in red ginseng extract thoroughly. METHODS: Red ginseng extract (RGE) and different fractions of RGE were prepared and evaluated by measuring the degranulation and viability of rat basophilic leukemia 2H3 (RBL-2H3) cells. Potential allergens were screened by RBL-2H3 cell extraction and allergenicity verified in RBL-2H3 cells, mouse peritoneal mast cells, Laboratory of Allergic Disease 2 (LAD2) human mast cells and mice, respectively...
June 28, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28561888/affiliation-with-substance-using-peers-examining-gene-environment-correlations-among-parent-monitoring-polygenic-risk-and-children-s-impulsivity
#19
Kit K Elam, Laurie Chassin, Kathryn Lemery-Chalfant, Danielle Pandika, Frances L Wang, Kaitlin Bountress, Danielle Dick, Arpana Agrawal
Parental monitoring can buffer the effect of deviant peers on adolescents' substance use by reducing affiliation with substance-using peers. However, children's genetic predispositions may evoke poorer monitoring, contributing to negative child outcomes. We examined evocative genotype-environment correlations underlying children's genetic predisposition for behavioral undercontrol and parental monitoring in early adolescence via children's impulsivity in middle childhood, and the influence of parental monitoring on affiliation with substance-using peers a year and a half later (n = 359)...
July 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28413317/korean-red-ginseng-improves-atopic-dermatitis-like-skin-lesions-by-suppressing-expression-of-proinflammatory-cytokines-and-chemokines-in%C3%A2-vivo-and-in%C3%A2-vitro
#20
Ji-Ye Kee, Yong-Deok Jeon, Dae-Seung Kim, Yo-Han Han, Jinbong Park, Dong-Hyun Youn, Su-Jin Kim, Kwang Seok Ahn, Jae-Young Um, Seung-Heon Hong
BACKGROUND: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-κB) pathway in allergic inflammation...
April 2017: Journal of Ginseng Research
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