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https://www.readbyqxmd.com/read/29773186/association-between-cadmium-and-androgen-receptor-protein-expression-differs-in-prostate-tumors-of-african-american-and-european-american-men
#1
Christine M Neslund-Dudas, Russell B McBride, Ashoka Kandegedara, Benjamin A Rybicki, Oleksandr N Kryvenko, Dhananjay Chitale, Nilesh Gupta, Sean R Williamson, Craig G Rogers, Carlos Cordon-Cardo, Andrew G Rundle, Albert M Levin, Q Ping Dou, Bharati Mitra
Cadmium is a known carcinogen that has been implicated in prostate cancer, but how it affects prostate carcinogenesis in humans remains unclear. Evidence from basic science suggests that cadmium can bind to the androgen receptor causing endocrine disruption. The androgen receptor is required for normal prostate development and is the key driver of prostate cancer progression. In this study, we examined the association between cadmium content and androgen receptor protein expression in prostate cancer tissue of African American (N = 22) and European American (N = 30) men...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29761845/the-o-methylated-isoflavone-formononetin-inhibits-human-ovarian-cancer-cell-proliferation-by-sub-g0-g1-cell-phase-arrest-through-pi3k-akt-and-erk1-2-inactivation
#2
Sunwoo Park, Fuller W Bazer, Whasun Lim, Gwonhwa Song
Formononetin is an isoflavone that is extracted from red clovers or soy. It has anti-oxidant, anti-proliferative, and anti-tumor effects against cells in various diseases. Several cohort studies have indicated that phytoestrogen intake, including formononetin, could reduce the risk of various carcinogenesis. In fact, many case-control studies have indicated the potential value of flavonoids as drug supplements in the treatment of many cancer patients. However, the toxic effects and the anti-cancer mechanism of formononetin in ovarian cancer are unknown...
May 15, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29761319/gaussian-graphical-models-identified-food-intake-networks-and-risk-of-type-2-diabetes-cvd-and-cancer-in-the-epic-potsdam-study
#3
Khalid Iqbal, Lukas Schwingshackl, Anna Floegel, Carolina Schwedhelm, Marta Stelmach-Mardas, Clemens Wittenbecher, Cecilia Galbete, Sven Knüppel, Matthias B Schulze, Heiner Boeing
PURPOSE: The aim of the study was to investigate the association between the previously identified Gaussian graphical models' (GGM) food intake networks and risk of major chronic diseases as well as intermediate biomarkers in the European Prospective Investigation into Cancer and nutrition (EPIC)-Potsdam cohort. METHODS: In this cohort analysis of 10,880 men and 13,340 women, adherence to the previously identified sex-specific GGM networks as well as principal component analysis identified patterns was investigated in relation to risk of major chronic diseases, using Cox-proportional hazard models...
May 14, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29758013/selenium-dependent-antioxidant-enzymes-actions-and-properties-of-selenoproteins
#4
REVIEW
Evangelos Zoidis, Isidoros Seremelis, Nikolaos Kontopoulos, Georgios P Danezis
Unlike other essential trace elements that interact with proteins in the form of cofactors, selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of 21st naturally occurring amino acid, selenocysteine (Sec), encoded by the UGA codon. Any protein that includes Sec in its polypeptide chain is defined as selenoprotein. Members of the selenoproteins family exert various functions and their synthesis depends on specific cofactors and on dietary Se. The Se intake in productive animals such as chickens affect nutrient utilization, production performances, antioxidative status and responses of the immune system...
May 14, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29751037/interaction-of-anti-cancer-drug-cisplatin-with-major-proteinase-inhibitor-alpha-2-macroglobulin-biophysical-and-thermodynamic-analysis
#5
Mohammad Khalid Zia, Tooba Siddiqui, Syed Saqib Ali, Haseeb Ahsan, FahimHalim Khan
Alpha-2-macroglobulin is a multifunctional, highly abundant, plasma protein which reacts with a wide variety of molecules and drugs such as cisplatin. Cisplatin is commonly used anticancer drug widely used for treatment of testicular, bladder, ovarian, head and neck, lung and cervical cancers. This study is designed to examine the interaction of cisplatin with human alpha-2-macroglobulin through various biophysical techniques and drug binding through molecular modeling. Cisplatin alters the function of alpha-2-macroglobulin and the thiolesters are most likely the reactive sites for cisplatin...
May 8, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29749015/usual-energy-and-macronutrient-intakes-in-a-large-sample-of-iranian-middle-aged-and-elderly-populations
#6
Zahra Heidari, Awat Feizi, Leila Azadbakht, Noushin Mohammadifard, Maryam Maghroun, Nizal Sarrafzadegan
AIM: The present study aimed to assess the usual distribution of energy and macronutrient intake among a large representative sample of Iranian healthy middle-aged and elderly people. METHODS: In this cross-sectional study, a second follow-up survey of the Isfahan Cohort Study (ICS) was carried out; 1922 people aged 40 years and older were investigated. Dietary intakes were collected using 24-hour recall and two or more consecutive food records. Distribution of energy and macronutrient intake was estimated using traditional and National Cancer Institute (NCI) methods...
May 10, 2018: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29738492/anthropometric-and-dietary-factors-as-predictors-of-dna-damage-in-obese-women
#7
Marta Włodarczyk, Beata Jabłonowska-Lietz, Wioletta Olejarz, Grażyna Nowicka
Enhanced DNA damage and disturbances in DNA repair mechanisms are reported to be involved in the pathogenesis of chronic diseases like obesity, atherosclerosis, metabolic syndrome, diabetes, and cancer. The aim of the present study was to evaluate whether anthropometric factors and dietary habits are related to endogenous DNA damage. One hundred and fourteen premenopausal, apparently healthy women were included in the study: 88 obese individuals and 26 controls. The comet assay was used to measure basal DNA damage...
May 8, 2018: Nutrients
https://www.readbyqxmd.com/read/29723088/molecular-alterations-associated-with-chronic-exposure-to-cigarette-smoke-and-chewing-tobacco-in-normal-oral-keratinocytes
#8
Pavithra Rajagopalan, Krishna Patel, Ankit P Jain, Vishalakshi Nanjappa, Keshava K Datta, Tejaswini Subbannayya, Kiran K Mangalaparthi, Anjali Kumari, Malini Manoharan, Coral Karunakaran, Sakthivel Murugan, Bipin Nair, T S Keshava Prasad, Premendu P Mathur, Ravi Gupta, Rohit Gupta, Arati Khanna-Gupta, Joseph Califano, David Sidransky, Harsha Gowda, Aditi Chatterjee
(250 words) Tobacco usage is a known risk factor associated with development of oral cancer. It is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, molecular alterations induced by tobacco are poorly understood. We therefore sought to investigate the adverse effects of cigarette smoke/chewing tobacco exposure in oral keratinocytes (OKF6/TERT1). OKF6/TERT1 cells acquired oncogenic phenotype after treating with cigarette smoke/chewing tobacco for a period of 8 months...
May 3, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29719601/increased-gut-permeability-in-cancer-cachexia-mechanisms-and-clinical-relevance
#9
Laure B Bindels, Audrey M Neyrinck, Audrey Loumaye, Emilie Catry, Hannah Walgrave, Claire Cherbuy, Sophie Leclercq, Matthias Van Hul, Hubert Plovier, Barbara Pachikian, Luis G Bermúdez-Humarán, Philippe Langella, Patrice D Cani, Jean-Paul Thissen, Nathalie M Delzenne
Intestinal disorders often occur in cancer patients, in association with body weight loss, and this alteration is commonly attributed to the chemotherapy. Here, using a mouse model of cancer cachexia induced by ectopic transplantation of C26 cancer cells, we discovered a profound alteration in the gut functions (gut permeability, epithelial turnover, gut immunity, microbial dysbiosis) independently of any chemotherapy. These alterations occurred independently of anorexia and were driven by interleukin 6. Gut dysfunction was found to be resistant to treatments with an anti-inflammatory bacterium ( Faecalibacterium prausnitzii ) or with gut peptides involved in intestinal cell renewal (teduglutide, a glucagon-like peptide 2 analogue)...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29713943/the-association-of-diet-gut-microbiota-and-colorectal-cancer-what-we-eat-may-imply-what-we-get
#10
REVIEW
Jia Yang, Jun Yu
Despite the success of colonoscopy screening and recent advances in cancer treatment, colorectal cancer (CRC) still remains one of the most commonly diagnosed and deadly cancers, with a significantly increased incidence in developing countries where people are adapting to Western lifestyle. Diet has an important impact on risk of CRC. Multiple epidemiological studies have suggested that excessive animal protein and fat intake, especially red meat and processed meat, could increase the risk of developing CRC while fiber could protect against colorectal tumorigenesis...
April 30, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29708079/barriers-to-cancer-nutrition-therapy-excess-catabolism-of-muscle-and-adipose-tissues-induced-by-tumour-products-and-chemotherapy
#11
Dalton L Schiessel, Vickie E Baracos
Cancer-associated malnutrition is driven by reduced dietary intake and by underlying metabolic changes (such as inflammation, anabolic resistance, proteolysis, lipolysis and futile cycling) induced by the tumour and activated immune cells. Cytotoxic and targeted chemotherapies also elicit proteolysis and lipolysis at the tissue level. In this review, we summarise specific mediators and chemotherapy effects that provoke excess proteolysis in muscle and excess lipolysis in adipose tissue. A nutritionally relevant question is whether and to what degree these catabolic changes can be reversed by nutritional therapy...
April 30, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29705061/dietary-inflammatory-potential-and-risk-of-mortality-in-metabolically-healthy-and-unhealthy-phenotypes-among-overweight-and-obese-adults
#12
Yong-Moon Mark Park, Moon Kyung Choi, Seong-Su Lee, Nitin Shivappa, Kyungdo Han, Susan E Steck, James R Hébert, Anwar T Merchant, Dale P Sandler
BACKGROUND & AIMS: This study was designed to investigate the association between the dietary inflammatory index (DII® ) scores, metabolic phenotypes, and risk of mortality risk in overweight/obese individuals from a representative sample of the U.S. POPULATION: <AbstractText Label="METHODS" NlmCategory="METHODS">Data from 3733 overweight/obese adults (BMI ≥ 25 kg/m2 ) aged 20-90 years from the National Health and Nutrition Examination Survey III, 1988-1994 were analyzed; these participants were followed for mortality through December 31, 2011...
April 16, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29702299/diets-that-promote-colon-inflammation-associate-with-risk-of-colorectal-carcinomas-that-contain-fusobacterium-nucleatum
#13
Li Liu, Fred K Tabung, Xuehong Zhang, Jonathan A Nowak, Zhi Rong Qian, Tsuyoshi Hamada, Daniel Nevo, Susan Bullman, Kosuke Mima, Keisuke Kosumi, Annacarolina da Silva, Mingyang Song, Yin Cao, Tyler S Twombly, Yan Shi, Hongli Liu, Mancang Gu, Hideo Koh, Wanwan Li, Chunxia Du, Yang Chen, Chenxi Li, Wenbin Li, Raaj S Mehta, Kana Wu, Molin Wang, Aleksander D Kostic, Marios Giannakis, Wendy S Garrett, Curtis Hutthenhower, Andrew T Chan, Charles S Fuchs, Reiko Nishihara, Shuji Ogino, Edward L Giovannucci
BACKGROUND & AIMS: Specific nutritional components are likely to induce intestinal inflammation, which is characterized by increased levels of interleukin 6 (IL6), C-reactive protein (CRP), and TNF receptor superfamily member 1B (TNFRSF1B) in the circulation and promotes colorectal carcinogenesis. The inflammatory effects of a diet can be estimated based on empirical dietary inflammatory pattern (EDIP) score, calculated based on intake of 18 foods associated with plasma levels of IL6, CRP, and TNFRSF1B...
April 24, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29686432/targeting-autophagy-in-obesity-from-pathophysiology-to-management
#14
REVIEW
Yingmei Zhang, James R Sowers, Jun Ren
Obesity poses a severe threat to human health, including the increased prevalence of hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and other chronic diseases. Current therapies focus mainly on suppressing caloric intake, but the efficacy of this approach remains poor. A better understanding of the pathophysiology of obesity will be essential for the management of obesity and its complications. Knowledge gained over the past three decades regarding the aetiological mechanisms underpinning obesity has provided a framework that emphasizes energy imbalance and neurohormonal dysregulation, which are tightly regulated by autophagy...
April 23, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29673830/is-telehealth-effective-in-managing-malnutrition-in-community-dwelling-older-adults-a-systematic-review-and-meta-analysis
#15
REVIEW
Wolfgang Marx, Jaimon T Kelly, Megan Crichton, Dana Craven, Jorja Collins, Hannah Mackay, Elizabeth Isenring, Skye Marshall
Telehealth offers a feasible method to provide nutrition support to malnourished older adults. This systematic review and meta-analysis aims to determine the efficacy of telehealth methods in delivering malnutrition-related interventions to community-dwelling older adults. Studies in any language were searched in five electronic databases from inception to 2nd November 2017. Quality of the evidence was assessed using the Cochrane Risk of Bias tool and the GRADE approach. Nine studies were identified, with results published across 13 included publications, which had mostly low to unclear risk of bias...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29670288/structural-basis-of-ligand-binding-modes-at-the-neuropeptide-y-y-1-receptor
#16
Zhenlin Yang, Shuo Han, Max Keller, Anette Kaiser, Brian J Bender, Mathias Bosse, Kerstin Burkert, Lisa M Kögler, David Wifling, Guenther Bernhardt, Nicole Plank, Timo Littmann, Peter Schmidt, Cuiying Yi, Beibei Li, Sheng Ye, Rongguang Zhang, Bo Xu, Dan Larhammar, Raymond C Stevens, Daniel Huster, Jens Meiler, Qiang Zhao, Annette G Beck-Sickinger, Armin Buschauer, Beili Wu
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology 1,2 . The NPY-Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y1 , Y2 , Y4 and Y5 receptors, with different affinity and selectivity 3 . NPY is the most powerful stimulant of food intake and this effect is primarily mediated by the Y1 receptor (Y1 R) 4 ...
April 18, 2018: Nature
https://www.readbyqxmd.com/read/29667485/amino-acid-kinetics-and-the-response-to-nutrition-in-patients-with-cancer
#17
Barbara S van der Meij, Laisa Teleni, Marielle Pkj Engelen, Nicolaas Ep Deutz
PURPOSE: Amino acids are involved in many physiological processes in the body and serve as building blocks of proteins which are the main component of muscle mass. Often patients with cancer experience muscle wasting, which is associated with poor outcomes. The purpose of this paper is to discuss amino acid kinetics in cancer, review the evidence on the response to nutrition in patients with cancer, and to give recommendations on the appropriate level of amino acid or protein intake in cancer...
April 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29662604/fr%C3%A3-quence-et-d%C3%A3-terminants-de-la-d%C3%A3-nutrition-post-op%C3%A3-ratoire-en-chirurgie-visc%C3%A3-rale-au-centre-national-hospitalier-et-universitaire-koutoucou-hubert-maga-cotonou-frequency-and-determinants-of-post-operative-undernutrition-in-patients-undergoing-visceral
#18
Adébayo Cossi Alassani, Adrien Montcho Hodonou, Albert Comlan Dovonou, Gaspard Dansou Gbessi, Séraphin Ahoui, Francis Moïse Dossou, Delphin Kouassi Mêhinto
This study aims to determine the frequency and identify the factors associated with undernutrition among patients undergoing visceral surgery in 2014. We conducted a cross-sectional, descriptive and analytical study over the period September 11, 2014-December 11, 2014. The study population comprised patients who had undergone visceral surgery at the National University Hospital Centre Koutoucou Hubert MAGA, Cotonou. Undernutrition is defined as a body mass index less than 18.5 kg/m2 . A total of 90 patients were included in the study, 57,78% (52 patients) were male...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29643982/nutrients-and-oxidative-stress-friend-or-foe
#19
REVIEW
Bee Ling Tan, Mohd Esa Norhaizan, Winnie-Pui-Pui Liew
There are different types of nutritionally mediated oxidative stress sources that trigger inflammation. Much information indicates that high intakes of macronutrients can promote oxidative stress and subsequently contribute to inflammation via nuclear factor-kappa B- (NF- κ B-) mediated cell signaling pathways. Dietary carbohydrates, animal-based proteins, and fats are important to highlight here because they may contribute to the long-term consequences of nutritionally mediated inflammation. Oxidative stress is a central player of metabolic ailments associated with high-carbohydrate and animal-based protein diets and excessive fat consumption...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29629346/lycopene-protects-against-spontaneous-ovarian-cancer-formation-in-laying-hens
#20
Kazim Sahin, Engin Yenice, Mehmet Tuzcu, Cemal Orhan, Cengizhan Mizrak, Ibrahim H Ozercan, Nurhan Sahin, Bahiddin Yilmaz, Birdal Bilir, Bulent Ozpolat, Omer Kucuk
Background: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans...
March 2018: Journal of Cancer Prevention
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