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https://www.readbyqxmd.com/read/29158891/overexpression-of-hypoxia-inducible-factor-and-metabolic-pathways-possible-targets-of-cancer
#1
REVIEW
Davinder Singh, Rohit Arora, Pardeep Kaur, Balbir Singh, Rahul Mannan, Saroj Arora
Cancer, the main cause of human deaths in the modern world is a group of diseases. Anticancer drug discovery is a challenge for scientists because of involvement of multiple survival pathways of cancer cells. An extensive study on the regulation of each step of these pathways may help find a potential cancer target. Up-regulated HIF-1 expression and altered metabolic pathways are two classical characteristics of cancer. Oxygen-dependent (through pVHL, PHDs, calcium-mediated) and independent (through growth factor signaling pathway, mdm2 pathway, HSP90) regulation of HIF-1α leads to angiogenesis, metastasis, and cell survival...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29140419/dietary-glutamine-glutamate-and-mortality-two-large-prospective-studies-in-us-men-and-women
#2
Wenjie Ma, Yoriko Heianza, Tao Huang, Tiange Wang, Dianjianyi Sun, Yan Zheng, Frank B Hu, Kathryn M Rexrode, JoAnn E Manson, Lu Qi
Background: Emerging studies have related circulating glutamine metabolites to various chronic diseases such as cardiovascular disease and cancer; diet is the major source of nutrients involved in glutamine metabolism. However, it remains unknown whether dietary intakes of glutamine, glutamate,and their ratio are related to total and cause-specific mortality. Methods: We followed 74 082 women from the Nurses' Health Study (1984-2012) and 42 303 men from the Health Professionals Follow-up Study (1986-2012), who were free of cardiovascular disease and cancer at baseline...
November 13, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29111172/nutritional-counseling-with-or-without-systematic-use-of-oral-nutritional-supplements-in-head-and-neck-cancer-patients-undergoing-radiotherapy
#3
Emanuele Cereda, Silvia Cappello, Sara Colombo, Catherine Klersy, Ilaria Imarisio, Annalisa Turri, Marilisa Caraccia, Valeria Borioli, Teresa Monaco, Marco Benazzo, Paolo Pedrazzoli, Franco Corbella, Riccardo Caccialanza
BACKGROUND: To evaluate the benefit of oral nutritional supplements (ONS) in addition to nutritional counseling in head and neck cancer (HNC) patients undergoing radiotherapy (RT). METHODS: In a single-center, randomized, pragmatic, parallel-group controlled trial (ClinicalTrials.gov: NCT02055833; February 2014-August 2016), 159 newly diagnosed HNC patients suitable for to RT regardless of previous surgery and induction chemotherapy were randomly assigned to nutritional counseling in combination with ONS (N = 78) or without ONS (N = 81) from the start of RT and continuing for up to 3 months after its end...
October 27, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29103966/an-update-of-research-evidence-on-nutrition-and-prostate-cancer
#4
REVIEW
Pao-Hwa Lin, William Aronson, Stephen J Freedland
BACKGROUND: Prostate cancer (PCa) remains a leading cause of mortality in US and other countries. Preclinical and clinical studies have examined the role of nutrition and dietary intake on the incidence and progression of PCa with mixed results. OBJECTIVE: The objective of this chapter is to provide an update of recent published literature and highlight progress in the field. MAIN FINDINGS: Low carbohydrate intake, soy protein, ω3 fat, green teas, tomatoes and tomato products and the herbal mixture-zyflamend showed promise in reducing PCa risk or progression...
November 2, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29101532/the-phytoestrogens-daidzein-and-equol-inhibit-the-drug-transporter-bcrp-abcg2-in-breast-cancer-cells-potential-chemosensitizing-effect
#5
Juan Pablo Rigalli, Paul Niklas Scholz, Guillermo Nicolás Tocchetti, María Laura Ruiz, Johanna Weiss
PURPOSE: The soy isoflavone genistein has been described to up-regulate breast cancer resistance protein (BCRP) and, thus, enhance chemoresistance in breast cancer cells. The aim of this work was to assess the effect of long- and short-term incubation with daidzein, the second most abundant soy isoflavone and its metabolite equol on the expression and activity of P-glycoprotein, multidrug resistance-associated proteins 1 and 2 (MRP1 and MRP2) and BCRP in breast cancer cells. METHODS: MCF-7 and MDA-MB-231 cells were treated with phytoestrogen concentrations within the range achieved in individuals with a high isoflavone intake...
November 3, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29065948/circadian-rhythms-nutrition-and-implications-for-longevity-in-urban-environments
#6
O Froy
Presently, about 12% of the population is 65 years or older and by the year 2030 that figure is expected to reach 21%. In order to promote the well-being of the elderly and to reduce the costs associated with health care demands, increased longevity should be accompanied by ageing attenuation. Energy restriction, which limits the amount of energy consumed to 60-70% of the daily intake, and intermittent fasting, which allows the food to be available ad libitum every other day, extend the life span of mammals and prevent or delay the onset of major age-related diseases, such as cancer, diabetes and cataracts...
October 25, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29061183/the-effects-of-epa-and-dha-enriched-fish-oil-on-nutritional-and-immunological-markers-of-treatment-na%C3%A3-ve-breast-cancer-patients-a-randomized-double-blind-controlled-trial
#7
Elemárcia Martins da Silva Paixão, Ana Carolina de M Oliveira, Nathalia Pizato, Maria Imaculada Muniz-Junqueira, Kelly G Magalhães, Eduardo Yoshio Nakano, Marina K Ito
BACKGROUND: We evaluated the effects of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids enriched fish oil (FO) on nutritional and immunological parameters of treatment naïve breast cancer patients. METHODS: In a randomized double blind controlled trial, the FO group (FG) patients were supplemented with 2 g/ day of FO concentrate containing 1.8 g of n-3 fatty acids during 30 days. The placebo group (PG) received 2 g/ day of mineral oil. At baseline and after the intervention, plasma levels of n-3 fatty acids, dietary intake, weight, body composition, biochemical and immunological markers were assessed...
October 23, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/29057328/cancer-prevention-and-treatment-by-wholistic-nutrition
#8
T Colin Campbell
Cancer is traditionally considered a genetic disease. It starts with a gene mutation, often caused by environmental carcinogens that are enzymatically activated to metabolites that covalently bind to DNA. If these now-damaged carcinogen-DNA adducts are not repaired before the cell replicates, they result in a mutation, which is inherited by daughter cells and their subsequent progeny. Still more mutations are added that are thought to advance cellular independence, metastasis, and drug resistance, among other characteristics typically observed for advanced cancer...
October 2017: Journal of Nature and Science
https://www.readbyqxmd.com/read/29052029/migration-and-invasion-induced-by-linoleic-acid-are-mediated-through-fascin-in-mda-mb-231-breast-cancer-cells
#9
Christian Gonzalez-Reyes, Cleofas Marcial-Medina, Nancy Cervantes-Anaya, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Epidemiological studies strongly suggest an association between high levels of dietary fat intake and an increased risk of developing breast cancer. Linoleic acid (LA) is an essential omega-6 PUFA and the major fatty acid in occidental diets. In breast cancer cells, LA induces expression of plasminogen activator inhibitor-1, proliferation, migration, and invasion. Fascin is an actin crosslinker globular protein that generates actin bundles made of parallel actin filaments, which mediate formation and stability of microspikes, stress fibers, membrane ruffles, and filopodia...
October 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29039280/very-long-chain-n-3-fatty-acids-and-human-health-fact-fiction-and-the-future
#10
P C Calder
EPA and DHA appear to be the most important n-3 fatty acids, but roles for n-3 docosapentaenoic acid are now also emerging. Intakes of EPA and DHA are usually low, typically below those recommended. Increased intakes result in higher concentrations of EPA and DHA in blood lipids, cells and tissues. Increased content of EPA and DHA modifies the structure of cell membranes and the function of membrane proteins. EPA and DHA modulate the production of lipid mediators and through effects on cell signalling can alter the patterns of gene expression...
October 17, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29022752/nutritional-characteristics-of-the-diets-of-child-and-adolescent-cancer-survivors
#11
Julia Ferrari Carneiro Teixeira, Priscila Dos Santos Maia-Lemos, Luciana Pellegrini Pisani
PURPOSE: Diseases associated with prior treatment, such as obesity, have been described in cancer survivors. Recent studies have shown that current estimates of overweight do not differ from that in the general population, suggesting the influence of environmental factors, such as dietary intake. In this context, there is increasing interest in the examination of health behaviors that may modify and reduce the risk of overweight and obesity. This study aimed to evaluate the characteristics of dietary intake among child cancer survivors living in a developing country...
October 12, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29016672/the-interaction-of-arsenic-and-n-butyl-n-4-hydroxybutyl-nitrosamine-on-urothelial-carcinogenesis-in-mice
#12
Yuan-Chang Dai, Shou-Chieh Wang, Mohammad Mezbahul Haque, Wei-Han Lin, Lei-Chen Lin, Ching-Hsein Chen, Yi-Wen Liu
The bladder is an important organ for the storage of excreted water and metabolites. If metabolites with carcinogenic characteristics are present in urine, the urothelial lining of the bladder could be damaged and genetically altered. In this study, we analyzed the interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) on mouse bladder carcinogenesis. Our previous study found that arsenic affects BBN-altered urothelial enzymatic activity, protein expression, DNA oxidation and global DNA CpG methylation levels...
2017: PloS One
https://www.readbyqxmd.com/read/28991196/phaseolus-acutifolius-lectin-fractions-exhibit-apoptotic-effects-on-colon-cancer-preclinical-studies-using-dimethilhydrazine-or-azoxi-methane-as-cancer-induction-agents
#13
Ulisses Moreno-Celis, Josué López-Martínez, Alejandro Blanco-Labra, Ricardo Cervantes-Jiménez, Laura Elena Estrada-Martínez, Alejandro Eduardo García-Pascalin, María De Jesús Guerrero-Carrillo, Adriana Jheny Rodríguez-Méndez, Carmen Mejía, Roberto Augusto Ferríz-Martínez, Teresa García-Gasca
Phaseolus acutifolius (Tepary bean) lectins have been studied as cytotoxic molecules on colon cancer cells. The toxicological profile of a Tepary bean lectin fraction (TBLF) has shown low toxicity in experimental animals; exhibiting anti-nutritional effects such as a reduction in body weight gain and a decrease in food intake when using a dose of 50 mg/kg on alternate days for six weeks. Taking this information into account, the focus of this work was to evaluate the effect of the TBLF on colon cancer using 1,2-dimethylhydrazine (DMH) or azoxy-methane/dextran sodium sulfate (AOM/DSS) as colon cancer inductors...
October 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28990868/prevention-of-recognition-memory-loss-and-moderation-of-mitochondrial-dynamic-tendency-toward-fusion-by-flavone-derivatives-in-a%C3%AE-injected-rats-a-comparison-between-two-flavonoids-with-different-polarity
#14
Farshad Arsalandeh, Fariba Khodagholi, Shahin Ahmadian, Forough Foolad, Hamed Mohammadi Kamsorkh, Mahdi Moridi Farimani, Fatemeh Shaerzadeh
Growing evidence sheds light on the use of flavonoids as the promising alternatives for the treatment of chronic conditions, including cancer and neurodegenerative disorders. Accordingly, in the present study, we aimed at evaluating the effects of oral intake of two structurally different flavonoids 5-hydroxy-6,7,4'-trimethoxyflavone (flavone 1) and 5,7,4'-trihydroxyflavone (flavone 2) on recognition memory, hippocampal protein level of immediate early gene cFos and mitochondrial dynamic markers in Amyloid β (Aβ)-injected rats...
October 9, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28990541/associations-of-dietary-patterns-with-bone-mass-muscle-strength-and-balance-in-a-cohort-of-australian-middle-aged-women
#15
Feitong Wu, Karen Wills, Laura L Laslett, Brian Oldenburg, Graeme Jones, Tania Winzenberg
Influences of dietary patterns on musculoskeletal health are poorly understood in middle-aged women. This cross-sectional analysis from a cohort of 347 women (aged 36-57 years) aimed to examine associations between dietary patterns and musculoskeletal health outcomes in middle-aged women. Diet was measured by the Cancer Council of Victoria FFQ. Total body bone mineral content (TB BMC), femoral neck and lumbar spine bone density (dual-energy X-ray absorptiometry), lower limbs muscle strength (LMS) and balance tests (timed up and go test, step test, functional reach test (FRT) and lateral reach test) were also measured...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28987769/insight-in-taste-alterations-during-treatment-with-protein-kinase-inhibitors
#16
REVIEW
A van der Werf, M Rovithi, J A E Langius, M A E de van der Schueren, H M W Verheul
The role of Protein Kinase Inhibitors (PKI) in the treatment of various types of cancer is increasingly prominent. Their clinical application is accompanied by the development of side effects, among which patient-reported taste alterations. These alterations are missed frequently, but impair nutritional intake, are associated with weight loss and often result in significant morbidity, especially in the context of chronic administration. Accurate reporting of taste alterations is hampered by lack of modules for symptom objectification and inadequate understanding on the underlying mechanisms...
October 4, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28957881/practical-approaches-to-managing-cancer-patients-with-weight-loss
#17
Egidio Del Fabbro, Tamara A Orr, Susan M Stella
PURPOSE OF REVIEW: Poor appetite and weight loss are a source of family conflict, psychological distress, and associated with poor tolerance to chemotherapy, impaired quality of life, and decreased survival. Despite clinicians' concern about the effect of cachexia on their patients, few oncological professional organizations provide guidelines for the treatment of cancer-related weight loss. RECENT FINDINGS: Recent publications indicate there is an unmet need for addressing cachexia in patients with cancer...
December 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28956832/multiple-gene-environment-interactions-on-the-angiogenesis-gene-pathway-impact-rectal-cancer-risk-and-survival
#18
Noha Sharafeldin, Martha L Slattery, Qi Liu, Conrado Franco-Villalobos, Bette J Caan, John D Potter, Yutaka Yasui
Characterization of gene-environment interactions (GEIs) in cancer is limited. We aimed at identifying GEIs in rectal cancer focusing on a relevant biologic process involving the angiogenesis pathway and relevant environmental exposures: cigarette smoking, alcohol consumption, and animal protein intake. We analyzed data from 747 rectal cancer cases and 956 controls from the Diet, Activity and Lifestyle as a Risk Factor for Rectal Cancer study. We applied a 3-step analysis approach: first, we searched for interactions among single nucleotide polymorphisms on the pathway genes; second, we searched for interactions among the genes, both steps using Logic regression; third, we examined the GEIs significant at the 5% level using logistic regression for cancer risk and Cox proportional hazards models for survival...
September 28, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28947887/link-between-diet-and-chemotherapy-related-gastrointestinal-side-effects
#19
Marcin Mardas, Radosław Madry, Marta Stelmach-Mardas
AIM OF THE STUDY: To evaluate an association between food products consumption, dietary intake and the incidence of selected gastrointestinal symptoms (nausea, vomiting, diarrhea and constipation) in cancer patients undergoing chemotherapy. MATERIAL AND METHODS: Fifty six women receiving chemotherapy for ovarian cancer were eligible for the study. Anthropometrical measurements were assessed. The dietary intake was evaluated by 24-hours food records. The association between the consumption of selected food products and gastrointestinal symptoms incidences was assessed by modified semi-quantitative food frequency questionnaire including 77-different food items that was developed and applied in cancer patients undergoing chemotherapy...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28941306/influence-of-various-factors-on-circulating-25-oh-vitamin-d-concentrations-in-dogs-with-cancer-and-healthy-dogs
#20
N Weidner, J P Woods, P Conlon, K A Meckling, J L Atkinson, J Bayle, A J Makowski, R L Horst, A Verbrugghe
BACKGROUND: Low blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations. OBJECTIVES: (1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs. ANIMALS: Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23)...
September 23, 2017: Journal of Veterinary Internal Medicine
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