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https://www.readbyqxmd.com/read/28209333/green-tea-extracts-for-the-prevention-of-metachronous-colorectal-polyps-among-patients-who-underwent-endoscopic-removal-of-colorectal-adenomas-a-randomized-clinical-trial
#1
Cheol Min Shin, Dong Ho Lee, A Young Seo, Hyun Joo Lee, Seong Beom Kim, Woo-Chan Son, Young Kyung Kim, Sang Jun Lee, Sung-Hee Park, Nayoung Kim, Young Soo Park, Hyuk Yoon
OBJECTIVES: To determine the preventive effect of green tea extract (GTE) supplements on metachronous colorectal adenoma and cancer in the Korean population. MATERIALS AND METHODS: One hundred seventy-six subjects (88 per each group) who had undergone complete removal of colorectal adenomas by endoscopic polypectomy were enrolled. They were randomized into 2 groups: supplementation group (0.9 g GTE per day for 12 months) or control group without GTE supplementation...
January 29, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28187402/effect-of-thai-banana-musa-aa-group-in-reducing-accumulation-of-oxidation-end-products-in-uvb-irradiated-mouse-skin
#2
Nontaphat Leerach, Swanya Yakaew, Preeyawass Phimnuan, Wichuda Soimee, Wongnapa Nakyai, Witoo Luangbudnark, Jarupa Viyoch
SCOPE: Chronic UVB exposure causes skin disorders and cancer through DNA strand breaks and oxidation of numerous functional groups of proteins and lipids in the skin. In this study, we investigated the effects of Thai banana (Musa AA group, "Khai," and Musa ABB group, "Namwa") on the prevention of UVB-induced skin damage when fed to male ICR mice. METHODS AND RESULTS: Mice were orally fed banana (Khai or Namwa) fruit pulps at dose of 1mg/g body weight/day for 12weeks...
February 2, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28177923/protein-calorie-malnutrition-nutritional-intervention-and-personalized-cancer-care
#3
Anju Gangadharan, Sung Eun Choi, Ahmed Hassan, Nehad M Ayoub, Gina Durante, Sakshi Balwani, Young Hee Kim, Andrew Pecora, Andre Goy, K Stephen Suh
Cancer patients often experience weight loss caused by protein calorie malnutrition (PCM) during the course of the disease or treatment. PCM is expressed as severe if the patient has two or more of the following characteristics: obvious significant muscle wasting, loss of subcutaneous fat; nutritional intake of <50% of recommended intake for 2 weeks or more; bedridden or otherwise significantly reduced functional capacity; weight loss of >2% in 1 week, 5% in 1 month, or 7.5% in 3 months. Cancer anorexia-cachexia syndrome (CACS) is a multifactorial condition of advanced PCM associated with underlying illness (in this case cancer) and is characterized by loss of muscle with or without loss of fat mass...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28168180/association-between-nutrient-intake-and-metabolic-syndrome-in-patients-with-colorectal-cancer
#4
Hee-Sook Lim, Eung-Jin Shin, Jeong-Won Yeom, Yoon-Hyung Park, Soon-Kyung Kim
The purpose of this study was to investigate the difference of nutritional status according to metabolic syndrome in colorectal cancer patients. The subjects were divided into 2 groups (metabolic syndrome group and normal group) according to the presence or absence of metabolic syndrome in 143 patients diagnosed with colorectal cancer, and their lifestyle and nutritional status were analyzed. Recall method was used for the dietary survey, and metabolic syndrome was defined as the presence of 3 or more of waist circumference, fasting blood glucose, triglyceride, high-density lipoprotein (HDL)-cholesterol, and blood pressure...
January 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28155612/the-influence-of-dietary-components-on-early-signs-of-atherosclerosis-in-apparently-healthy-young-adult-males-an-observational-study-of-615-subjects
#5
Girolamo Catapano Minotti, Francesca Cortese, Andrea Corsonello, Giovanni Guadalupi, Antonio Paolo D Arcangelo, Saverio Daniele Palumbo, Rita Naio, Ottovio De Clemente, Andrea Aurelio, Simona Carone, Tiziana Gelsumino, Vincenzo Gemignani, Elisabetta Bianchini, Mariangela Vigotti, Francesco Faita, Luciano Greco, Roberto Primerano, Raffaele Antonelli Incalzi, Marco Matteo Ciccone
BACKGROUND: the literature shows that a healthy diet, rich in fruits and vegetables, has positive effects on overall cardiovascular risk, protecting against atherosclerosis. DESIGN: a cross sectional study in a population of apparently healthy young-adult men with the aim of investigating dietary determinants of early atherosclerosis, assessed by measuring carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) of the brachial artery. METHODS: 615 males (mean age ± SD: 40...
February 1, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28153960/race-dependent-association-of-sulfidogenic-bacteria-with-colorectal-cancer
#6
Cemal Yazici, Patricia G Wolf, Hajwa Kim, Tzu-Wen L Cross, Karin Vermillion, Timothy Carroll, Gaius J Augustus, Ece Mutlu, Lisa Tussing-Humphreys, Carol Braunschweig, Rosa M Xicola, Barbara Jung, Xavier Llor, Nathan A Ellis, H Rex Gaskins
OBJECTIVE: Colorectal cancer (CRC) incidence is higher in African Americans (AAs) compared with non-Hispanic whites (NHWs). A diet high in animal protein and fat is an environmental risk factor for CRC development. The intestinal microbiota is postulated to modulate the effects of diet in promoting or preventing CRC. Hydrogen sulfide, produced by autochthonous sulfidogenic bacteria, triggers proinflammatory pathways and hyperproliferation, and is genotoxic. We hypothesised that sulfidogenic bacterial abundance in colonic mucosa may be an environmental CRC risk factor that distinguishes AA and NHW...
February 2, 2017: Gut
https://www.readbyqxmd.com/read/28150350/nutrient-intakes-and-compliance-with-nutrient-recommendations-in-children-aged-1-4-years-in-ireland
#7
J Walton, L Kehoe, B A McNulty, A P Nugent, A Flynn
BACKGROUND: The early childhood years represent a period of rapid growth and development characterised by unique requirements for energy and individual nutrients. METHODS: The present study uses data from the National Pre-School Nutrition Survey, a nationally representative sample of Irish children (1-4 years) (n = 500), aiming to estimate energy and nutrient intakes across age and compliance with recommendations (UK and European). A 4-day weighed food-record was used to collect dietary data and statistical modelling (National Cancer Institute method) was applied to estimate usual nutrient intakes...
February 2, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28148690/lifetime-genistein-intake-increases-the-response-of-mammary-tumors-to-tamoxifen-in-rats
#8
Xiyuan Zhang, Katherine L Cook, Anni Warri, Idalia M Cruz, Mariana Rosim, Jeffrey Riskin, William Helferich, Daniel Doerge, Robert Clarke, Leena Hilakivi-Clarke
PURPOSE: Whether it is safe for estrogen receptor-positive (ER+) patients with breast cancer to consume soy isoflavone genistein remains controversial. We compared the effects of genistein intake mimicking either Asian (lifetime) or Caucasian (adulthood) intake patterns to that of starting its intake during tamoxifen therapy using a preclinical model. EXPERIMENTAL DESIGN: Female Sprague-Dawley rats were fed an AIN93G diet supplemented with 0 (control diet) or 500 ppm genistein from postnatal day 15 onward (lifetime genistein)...
February 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28143855/-nutraceuticals-in-relation-to-human-skeletal-muscle-and-exercise
#9
Colleen Siobhan Deane, Daniel J Wilkinson, Bethan E Phillips, Kenneth Smith, Timothy Etheridge, Philip J Atherton
Skeletal muscles have a fundamental role in locomotion and whole body metabolism, with muscle mass and quality being linked to improved health and even lifespan. Optimising nutrition in combination with exercise is considered an established, effective ergogenic practice for athletic performance. Importantly, exercise and nutritional approaches also remain arguably the most effective countermeasure for muscle dysfunction associated with ageing and numerous clinical conditions e.g. cancer cachexia, COPD and organ failure, via engendering favourable adaptations such as increased muscle mass and oxidative capacity...
January 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28143460/chlorella-sorokiniana-induces-mitochondrial-mediated-apoptosis-in-human-non-small-cell-lung-cancer-cells-and-inhibits-xenograft-tumor-growth-in-vivo
#10
Ping-Yi Lin, Ching-Tsan Tsai, Wan-Ling Chuang, Ya-Hsuan Chao, I-Horng Pan, Yu-Kuo Chen, Chi-Chen Lin, Bing-Yen Wang
BACKGROUND: Lung cancer is one of the leading causes of cancer related deaths worldwide. Marine microalgae are a source of biologically active compounds and are widely consumed as a nutritional supplement in East Asian countries. It has been reported that Chlorella or Chlorella extracts have various beneficial pharmacological compounds that modulate immune responses; however, no studies have investigated the anti-cancer effects of Chlorella sorokiniana (CS) on non-small cell lung cancer (NSCLC)...
February 1, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28127199/mitochondrial-carnitine-palmitoyl-transferase-ii-inactivity-aggravates-lipid-accumulation-in-rat-hepatocarcinogenesis
#11
Juan-Juan Gu, Min Yao, Jie Yang, Yin Cai, Wen-Jie Zheng, Li Wang, Deng-Bing Yao, Deng-Fu Yao
AIM: To investigate the dynamic alteration of mitochondrial carnitine palmitoyl transferase II (CPT-II) expression during malignant transformation of rat hepatocytes. METHODS: Sprague-Dawley male rats were fed with normal, high fat (HF), and HF containing 2-fluorenylacetamide (2-FAA) diet, respectively. According to the Hematoxylin and Eosin staining of livers, rats were divided into control, fatty liver, degeneration, precancerous, and cancerous groups. Liver lipids were dyed with Oil Red O, CPT-II alterations were analyzed by immunohistochemistry, and compared with CPT-II specific concentration (μg/mg protein)...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28116152/the-effects-of-compliance-with-nutritional-counselling-on-body-composition-parameters-in-head-and-neck-cancer-patients-under-radiotherapy
#12
D Hopanci Bicakli, O Ozkaya Akagunduz, R Meseri Dalak, M Esassolak, R Uslu, M Uyar
Background. Radiotherapy (RT) has been associated with increased risk of malnutrition in cancer patients, particularly in those with head and neck cancer (HNC). The aim of this prospective study was to evaluate the effects of compliance of patients with individual dietary counselling on body composition parameters in HNC patients under RT. Material and Methods. Sixty-nine consecutive patients (mean age: 61.0 ± 13.8) were prospectively followed. Bioelectrical impedance analysis (BIA) was performed to determine body composition parameters before, in the middle of, and at the end of RT...
2017: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/28112357/calpain-inhibitors-ameliorate-muscle-wasting-in-a-cachectic-mouse-model-bearing-ct26-colorectal-adenocarcinoma
#13
Xing-Yu Lin, Si-Zeng Chen
Cancer-related cachexia involves increased protein breakdown through various proteolytic pathways, including the ubiquitin-proteasome pathway (UPP). We hypothesized that a calcium- and calpain-dependent pathway might play a crucial role during the proteolytic procedure, and that pathway interventions would ameliorate cancer cachexia in vivo. After being inoculated with CT26 adenocarcinoma cell culture subcutaneously, BALB/c mice developed cachexia in 12 days. They were then administered with different types of calpain inhibitors individually or in combination for 7 consecutive days...
January 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28109460/dietary-protein-sources-and-all-cause-and-cause-specific-mortality-the-golestan-cohort-study-in-iran
#14
Maryam S Farvid, Akbar F Malekshah, Akram Pourshams, Hossein Poustchi, Sadaf G Sepanlou, Maryam Sharafkhah, Masoud Khoshnia, Mojtaba Farvid, Christian C Abnet, Farin Kamangar, Sanford M Dawsey, Paul Brennan, Paul D Pharoah, Paolo Boffetta, Walter C Willett, Reza Malekzadeh
INTRODUCTION: Dietary protein comes from foods with greatly different compositions that may not relate equally with mortality risk. Few cohort studies from non-Western countries have examined the association between various dietary protein sources and cause-specific mortality. Therefore, the associations between dietary protein sources and all-cause, cardiovascular disease, and cancer mortality were evaluated in the Golestan Cohort Study in Iran. METHODS: Among 42,403 men and women who completed a dietary questionnaire at baseline, 3,291 deaths were documented during 11 years of follow up (2004-2015)...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28107038/prevalence-of-and-factors-associated-with-sarcopenia-in-korean-cancer-survivors-based-on-data-obtained-by-the-korea-national-health-and-nutrition-examination-survey-knhanes-2008-2011
#15
Eun Young Kim, Kirang Kim, Young Saing Kim, Hee Kyung Ahn, Yu Mi Jeong, Jeong Ho Kim, Won-Jun Choi
Using a representative dataset from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011, we analyzed anthropometric and dual-energy X-ray absorptiometry (DXA)-determined body composition findings for 493 cancer survivors (mean age a61.1 ± 12.6 years; 35.7% male). A much higher proportion of men (30.1%) than women (0.6%) met the criteria of sarcopenia. Subjects with a history of lung cancer, genitourinary cancer, or gastric cancer were prone to develop sarcopenia (31.6%, 26...
January 20, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28105624/-clinical-research-of-delta-shaped-anastomosis-technology-in-laparoscopic-distal-gastrectomy-and-digestive-tract-reconstruction
#16
Bo Gao, Qingxing Huang, Jianhong Dong
OBJECTIVE: To evaluate the feasibility and safety of the delta-shaped anastomosis in laparoscopic distal gastrectomy and digestive tract reconstruction. METHODS: Clinical data of 34 gastric cancer patients undergoing laparoscopic distal gastrectomy with the delta-shaped anastomosis for digestive tract reconstruction (delta-shaped group) and 83 gastric cancer patients undergoing laparoscopic distal gastrectomy with Billroth I( for digestive tract reconstruction (Billroth group) by same surgeon team from July 2013 to July 2015 at the Department of Digestive Surgery, Affiliated Tumor Hospital of Shanxi Medical University were retrospectively analyzed...
January 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28095274/protein-intake-and-breast-cancer-survival-in-the-nurses-health-study
#17
Michelle D Holmes, Jun Wang, Susan E Hankinson, Rulla M Tamimi, Wendy E Chen
Purpose Greater protein intake has been associated with better breast cancer survival in several prospective studies, including among 1,982 women in the Nurses' Health Study. We proposed to extend this previous finding. We hypothesized that protein, essential amino acid, branched-chain amino acid, and leucine intakes are associated with improved survival and that these associations are stronger in tumors expressing insulin receptor (IR). Patients and Methods We included 6,348 women diagnosed with stage I to III breast cancer between 1976 and 2004...
January 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28095125/nitrate-in-drinking-water-and-risk-of-colorectal-cancer-in-yogyakarta-indonesia
#18
Fathmawati, Jajah Fachiroh, Evi Gravitiani, Sarto, Adi Heru Husodo
Nitrate concentration in well water in Yogyakarta, Indonesia, and its surroundings tended to increase rapidly from time to time, and it may be associated with an elevated risk for several types of cancer. The purpose of this study was to examine the association between nitrate in drinking water and colorectal cancer (CRC) risk occurrence. A case-control study was conducted in Yogyakarta Special Province. Pathologically confirmed 75 CRC patients and 75 controls were consulted and their individual well water was sampled and examined for nitrate concentrations...
January 17, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28094342/optimizing-isothiocyanate-formation-during-enzymatic-glucosinolate-breakdown-by-adjusting-ph-value-temperature-and-dilution-in-brassica-vegetables-and-arabidopsis-thaliana
#19
Franziska S Hanschen, Rebecca Klopsch, Teresa Oliviero, Monika Schreiner, Ruud Verkerk, Matthijs Dekker
Consumption of glucosinolate-rich Brassicales vegetables is associated with a decreased risk of cancer with enzymatic hydrolysis of glucosinolates playing a key role. However, formation of health-promoting isothiocyanates is inhibited by the epithiospecifier protein in favour of nitriles and epithionitriles. Domestic processing conditions, such as changes in pH value, temperature or dilution, might also affect isothiocyanate formation. Therefore, the influences of these three factors were evaluated in accessions of Brassica rapa, Brassica oleracea, and Arabidopsis thaliana...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093897/presence-of-early-stage-cancer-does-not-impair-the-early-protein-metabolic-response-to-major-surgery
#20
Mariëlle P K J Engelen, V Suzanne Klimberg, Arianna Allasia, Nicolaas Ep Deutz
BACKGROUND: Combined bilateral mastectomy and reconstruction is a common major surgical procedure in women with breast cancer and in those with a family history of breast cancer. As this large surgical procedure induces muscle protein loss, a preserved anabolic response to nutrition is warranted for optimal recovery. It is unclear whether the presence of early stage cancer negatively affects the protein metabolic response to major surgery as this would mandate perioperative nutritional support...
January 16, 2017: Journal of Cachexia, Sarcopenia and Muscle
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