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benign childhood epilepsy

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https://www.readbyqxmd.com/read/30384100/benign-rolandic-epilepsy-of-childhood-and-central-auditory-processing-disorder-a-noncasual-neurophysiological-association
#1
Marília Matos, Tiago Bara, Samira Clark, Bianca Simone Zeigelboim, Jair Mendes Marques, Paulo Breno Noronha Liberalesso
PURPOSE: The purpose of this study was to demonstrate the association between benign rolandic epilepsy of childhood (BREC) and central auditory processing disorders (CAPDs) and to test the hypothesis that an early onset of BREC could be associated with more cases of CAPD. METHOD: This study has a retrospective cross-sectional design conducted from January 2006 to January 2016 including 93 patients with BREC and without intellectual disability, dyslexia, and attention-deficit hyperactivity disorders...
October 25, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30251989/-speech-and-language-neurodevelopmental-disorders-in-epilepsy-pathophysiologic-mechanisms-and-therapeutic-approaches
#2
N N Zavadenko, A A Kholin, A N Zavadenko, E S Michurina
Speech and language development may be impaired in all forms of epilepsy involving specialized functional areas in the dominant cerebral hemisphere and their connections. The concept of epilepsy-aphasia clinical spectrum was recently proposed, but the notion of aphasia is quite conditional here as many of these patients demonstrate disorders of speech and language development from their infancy. Those forms of epilepsy are considered as continuum from the most severe Landau-Kleffner syndrome (LKS) and epilepsy with continuous spike-and-wave during sleep (CSWS) (also indicating as electrical status epilepticus during sleep - ESES) to intermediate epilepsy-aphasia disorders (with incomplete correspondence to diagnostic criteria of LKS and epilepsy with CSWS)...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30219586/benign-epilepsy-with-centrotemporal-spikes-current-concepts-of-diagnosis-and-treatment
#3
REVIEW
P Dryżałowski, S Jóźwiak, M Franckiewicz, J Strzelecka
Benign epilepsy with centrotemporal spikes (BECTS) is the most common focal epilepsy of the childhood and also one of the best known. It has a proclivity to start at a particular age and remit spontaneously before adolescence. Majority of patients may avoid long-term treatment, because of the mild course and very good outcome. Only few patients may present cognitive deficits if the proper treatment is not implied. BECTS is a part of heterogeneous group of syndromes that consists of Landau-Kleffner Syndrome (LKS), Continuous Spike-and-Wave during Sleep (CSWS) and Atypical benign partial epilepsy (ABPE)...
September 7, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/30198231/effects-of-antiepileptic-drugs-on-language-abilities-in-benign-epilepsy-of-childhood-with-centrotemporal-spikes
#4
Min Jeong Han, Sun Jun Kim
BACKGROUND AND PURPOSE: This study is to assess the responsiveness of electroencephalography (EEG) abnormalities and their effects on language ability after initiating different types of antiepileptic therapy in children with newly diagnosed benign epilepsy of childhood with centrotemporal spikes (BECTS). METHODS: The records of patients newly diagnosed with BECTS ( n =120; 69 males) were reviewed retrospectively. The patients were randomly treated with lamotrigine, oxcarbazepine, or topiramate monotherapy, and underwent at least two EEG and standardized language tests...
October 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/30146685/transient-microstructural-brain-anomalies-and-epileptiform-discharges-in-mice-defective-for-epilepsy-and-language-related-nmda-receptor-subunit-gene-grin2a
#5
Manal Salmi, Radu Bolbos, Sylvian Bauer, Marat Minlebaev, Nail Burnashev, Pierre Szepetowski
OBJECTIVE: The epilepsy-aphasia spectrum (EAS) is a heterogeneous group of age-dependent childhood disorders characterized by sleep-activated discharges associated with infrequent seizures and language, cognitive, and behavioral deficits. Defects in the GRIN2A gene, encoding a subunit of glutamate-gated N-methyl-d-aspartate (NMDA) receptors, represent the most important cause of EAS identified so far. Neocortical or thalamic lesions were detected in a subset of severe EAS disorders, and more subtle anomalies were reported in patients with so-called "benign" phenotypes...
October 2018: Epilepsia
https://www.readbyqxmd.com/read/30137548/epilepsy-surgery-in-the-first-3-years-of-life-predictors-of-seizure-freedom-and-cognitive-development
#6
Navah Ester Kadish, Thomas Bast, Gitta Reuner, Kathrin Wagner, Hans Mayer, Susanne Schubert-Bast, Gert Wiegand, Karl Strobl, Armin Brandt, Rudolf Korinthenberg, Vera van Velthoven, Andreas Schulze-Bonhage, Josef Zentner, Georgia Ramantani
BACKGROUND: Although the majority of children undergoing epilepsy surgery are younger than 3 yr at epilepsy manifestation, only few actually receive surgical treatment in early childhood. Past studies have, however, suggested that earlier intervention may correlate with superior developmental outcomes. OBJECTIVE: To identify predictors for long-term seizure freedom and cognitive development following epilepsy surgery in the first 3 yr of life and determine the appropriate timing for surgical treatment in this age group...
August 21, 2018: Neurosurgery
https://www.readbyqxmd.com/read/30120072/abnormal-cortical-activation-during-an-auditory-word-comprehension-task-in-benign-childhood-epilepsy-with-centrotemporal-spikes-a-magnetoencephalographic-study
#7
Kuriko Kagitani-Shimono, Yoko Kato, Ryuzo Hanaie, Junko Matsuzaki, Junpei Tanigawa, Yoshiko Iwatani, Junji Azuma, Masako Taniike
OBJECTIVE: Benign childhood epilepsy with centrotemporal spikes (BECTS), also known as rolandic epilepsy, has recently been reported to be associated with variable degrees of cognitive dysfunction. Many studies reported poor language ability in children with BECTS compared with healthy control children. To elucidate the harmful effects of BECTS on language cognition, we studied the magnetoencephalographic activity elicited by an auditory language comprehension task. METHODS: The participants (N = 20) included 10 children diagnosed with BECTS (aged 10...
August 14, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30048931/frequency-specific-alterations-in-the-amplitude-and-synchronization-of-resting-state-spontaneous-low-frequency-oscillations-in-benign-childhood-epilepsy-with-centrotemporal-spikes
#8
Ge Tan, Fenglai Xiao, Sihan Chen, Haijiao Wang, Deng Chen, Lina Zhu, Da Xu, Dong Zhou, Ling Liu
OBJECTIVES: Spontaneous low-frequency oscillations in different frequency bands have diverse physiological meanings. The amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) in different frequency bands in Benign Childhood Epilepsy with Centrotemporal Spikes (BECTS) are unknown and worth exploring. METHOD: Resting-state functional magnetic resonance imaging data were collected in 51 drug-naïve BECTS patients and 76 healthy controls. The ALFF was calculated for the typical (0...
September 2018: Epilepsy Research
https://www.readbyqxmd.com/read/30038660/febrile-seizures-an-overview
#9
REVIEW
Alexander Kc Leung, Kam Lun Hon, Theresa Nh Leung
Background: Febrile seizures are the most common neurologic disorder in childhood. Physicians should be familiar with the proper evaluation and management of this common condition. Objective: To provide an update on the current understanding, evaluation, and management of febrile seizures. Methods: A PubMed search was completed in Clinical Queries using the key terms 'febrile convulsions' and 'febrile seizures'. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews...
2018: Drugs in Context
https://www.readbyqxmd.com/read/30031676/could-rolandic-spikes-be-a-prognostic-factor-of-the-neurocognitive-outcome-of-children-with-bects
#10
Isabella Tristano, Francesco Nicita, Giacomo Garone, Fabiana Ursitti, Consuelo Nardone, Valerio Rocchi, Cristiana Alessia Guido, Alberto Spalice
INTRODUCTION: Rolandic epilepsy, also known as benign childhood epilepsy with centrotemporal spikes (BECTS), is one of the most common epileptic syndromes in previously healthy children. Despite what was known about the benignity of this syndrome, there is always more evidence about the involvement of the cognitive functions with different deficits in several domains to be investigated. AIM OF THE STUDY: The aim of our study was to describe prognostic electroencephalogram (EEG) pattern of an adverse cognitive development to recognize patients at higher risk of lasting cognitive deficits that could need antiepileptic drugs (AEDs) or an improved neurocognitive therapy...
September 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30005220/enhancement-and-bilateral-synchronization-of-ripples-in-atypical-benign-epilepsy-of-childhood-with-centrotemporal-spikes
#11
Satoru Ikemoto, Shin-Ichiro Hamano, Susumu Yokota, Reiko Koichihara, Yuko Hirata, Ryuki Matsuura
OBJECTIVE: To determine whether the characteristics of scalp-recorded high frequency oscillations, especially ripples, can predict the "atypical forms" of benign epilepsy of childhood with centrotemporal spikes (ABECTS), in BECTS. METHODS: Seven patients with ABECTS and eighteen patients with BECTS underwent electroencephalography (EEG) in the secondary bilateral synchrony (SBS) and non-SBS periods for ABECTS patients. SBS period is that when more than 50% of the interictal epileptiform discharges (IEDs) are bilaterally synchronized...
September 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29996185/-phenotype-study-of-scn2a-gene-related-epilepsy
#12
Q Zeng, Y H Zhang, X L Yang, J Zhang, A J Liu, X Y Liu, Y W Jiang, X R Wu
Objective: To summarize the phenotype of epileptic children with SCN2A mutations. Methods: Epileptic patients who were treated in the Pediatric Department of Peking University First Hospital from September 2006 to October 2017 and detected with SCN2A mutations by targeted next-generation sequencing were enrolled. Clinical manifestations of all patients were analyzed retrospectively. Results: A total of 21 patients (16 boys and 5 girls) with SCN2A mutations were collected. Twenty-one SCN2A mutations were identified...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29896722/-study-of-grin2a-mutation-in-epilepsy-aphasia-spectrum-disorders
#13
Ping Qian, Xiaoling Yang, Xiaojing Xu, Xiaoyan Liu, Yuehua Zhang, Zhixian Yang
OBJECTIVE: To detect potential mutations of the glutamate receptor subunit (GRIN2A) gene and delineate the clinical-genetic characteristics of patients with epilepsy-aphasia spectrum (EAS) disorders. METHODS: One hundred twenty two patients with Landau-Kleffner syndrome (LKS), epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS), benign childhood epilepsy with centrotemporal spikes (BECT) and BECT variants were recruited. Potential mutations of the GRIN2A gene were screened with Sanger sequencing...
June 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29790011/consecutive-occurrence-of-benign-epilepsy-with-centro-temporal-spike-and-childhood-absence-epilepsy-true-coexistence-or-atypical-evolution
#14
LETTER
Eun Hye Lee, Hoi Soo Yoon
No abstract text is available yet for this article.
August 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29774303/myotonia-permanens-with-nav1-4-g1306e-displays-varied-phenotypes-during-course-of-life
#15
Frank Lehmann-Horn, Adele D'Amico, Enrico Bertini, Mauro Lomonaco, Luciano Merlini, Kevin R Nelson, Heike Philippi, Gabriele Siciliano, Frank Spaans, Karin Jurkat-Rott
Introduction: Myotonia permanens due to Nav1.4-G1306E is a rare sodium channelopathy with potentially life-threatening respiratory complications. Our goal was to study phenotypic variability throughout life. Methods: Clinical neurophysiology and genetic analysis were performed. Using existing functional expression data we determined the sodium window by integration. Results: In 10 unrelated patients who were believed to have epilepsy, respiratory disease or Schwartz-Jampel syndrome, we made the same prima facie diagnosis and detected the same heterologous Nav1...
September 2017: Acta Myologica: Myopathies and Cardiomyopathies: Official Journal of the Mediterranean Society of Myology
https://www.readbyqxmd.com/read/29730501/language-skills-in-children-with-benign-childhood-epilepsy-with-centrotemporal-spikes-a-systematic-review
#16
REVIEW
Joana Teixeira, Maria Emília Santos
Benign childhood epilepsy with centrotemporal spikes (BECTS) is the epileptic syndrome that most affects preschool and school-age children. Despite being usually considered a benign condition, several studies have shown that this epileptic syndrome is responsible for cognitive morbidities in children, namely at the level of attention and memory, as well as language. However, language disorders are still superficially addressed by the literature. This review aimed to compile and synthesize recent literature in this area...
July 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29720203/detection-rate-of-causal-variants-in-severe-childhood-epilepsy-is-highest-in-patients-with-seizure-onset-within-the-first-four-weeks-of-life
#17
David Staněk, Petra Laššuthová, Katalin Štěrbová, Markéta Vlčková, Jana Neupauerová, Marcela Krůtová, Pavel Seeman
BACKGROUND: Epilepsy is a heterogeneous disease with a broad phenotypic spectrum and diverse genotypes. A significant proportion of epilepsies has a genetic aetiology. In our study, a custom designed gene panel with 112 genes known to be associated with epilepsies was used. In total, one hundred and fifty-one patients were tested (86 males / 65 females). RESULTS: In our cohort, the highest probability for the identification of the cause of the disease was for patients with a seizure onset within the first four weeks of life (61...
May 2, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29649723/the-relevance-of-attention-deficit-hyperactivity-disorder-in-self-limited-childhood-epilepsy-with-centrotemporal-spikes
#18
Ellen Marise Lima, Patricia Rzezak, Bernardo Dos Santos, Letícia Gentil, Maria A Montenegro, Marilisa M Guerreiro, Kette D Valente
In this study, we aimed to evaluate the attentional and executive functions in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS) with and without attention-deficit hyperactivity disorder (ADHD) compared with controls and compared with patients with ADHD without epilepsy. We evaluated 12 patients with BCECTS and ADHD (66.7% boys; mean age of 9.67years); 11 children with non-ADHD BCECTS (63.6% boys; mean age of 11.91years); 20 healthy children (75% boys; mean age of 10.15years); and 20 subjects with ADHD without epilepsy (60% boys; mean age of 10...
May 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29629540/role-of-language-related-functional-connectivity-in-patients-with-benign-childhood-epilepsy-with-centrotemporal-spikes
#19
Hyeon Jin Kim, Jung Hwa Lee, Chang Hyun Park, Hye Sun Hong, Yun Seo Choi, Jeong Hyun Yoo, Hyang Woon Lee
BACKGROUND AND PURPOSE: Benign childhood epilepsy with centrotemporal spikes (BECTS) does not always have a benign cognitive outcome. We investigated the relationship between cognitive performance and altered functional connectivity (FC) in the resting-state brain networks of BECTS patients. METHODS: We studied 42 subjects, comprising 19 BECTS patients and 23 healthy controls. Cognitive performance was assessed using the Korean version of the Wechsler Intelligence Scale for Children-III, in addition to verbal and visuospatial memory tests and executive function tests...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29610055/language-function-in-childhood-idiopathic-epilepsy-syndromes
#20
D C Jackson, J E Jones, D A Hsu, C E Stafstrom, J J Lin, D Almane, M A Koehn, M Seidenberg, B P Hermann
PURPOSE: To examine the impact of diverse syndromes of focal and generalized epilepsy on language function in children with new and recent onset epilepsy. Of special interest was the degree of shared language abnormality across epilepsy syndromes and the unique effects associated with specific epilepsy syndromes. METHODS: Participants were 136 youth with new or recent-onset (diagnosis within past 12 months) epilepsy and 107 healthy first-degree cousin controls...
March 30, 2018: Brain and Language
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