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diarrhea and probiotics

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https://www.readbyqxmd.com/read/28434154/protective-effects-of-cell-free-supernatant-and-live-lactic-acid-bacteria-isolated-from-thai-pigs-against-a-pandemic-strain-of-porcine-epidemic-diarrhea-virus
#1
Wandee Sirichokchatchawan, Gun Temeeyasen, Dachrit Nilubol, Nuvee Prapasarakul
Porcine epidemic diarrhea virus (PEDV) is a coronavirus which causes severe diarrhea and fatal dehydration in piglets. In general, probiotic supplements could enhance recovery and protect piglets against enteric pathogens. Seven local lactic acid bacteria (LAB), (Ent. faecium 79N and 40N, Lact. plantarum 22F, 25F and 31F, Ped. acidilactici 72N and Ped. pentosaceus 77F) from pig feces were well-characterized as high potential probiotics. Cell-free supernatants (CFS) and live LAB were evaluated for antiviral activities by co-incubation on Vero cells and challenged with a pandemic strain of PEDV isolated from pigs in Thailand...
April 22, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28432676/bifidobacterium-adolescentis-dsm-20083-and-lactobacillus-casei-lafti-l26-dsl-probiotics-able-to-block-the-in-vitro-adherence-of-rotavirus-in-ma104-cells
#2
Karem Prunella Fernandez-Duarte, Nury Nathalia Olaya-Galán, Sandra Patricia Salas-Cárdenas, Jazmin Lopez-Rozo, Maria Fernanda Gutierrez-Fernandez
Rotavirus is the leading worldwide cause of gastroenteritis in children under five years of age. Even though there are some available vaccines to prevent the disease, there are limited strategies for challenging diarrhea induced by rotavirus infection. For this reason, researchers are constantly searching for other approaches to control diarrhea by means of probiotics. In order to demonstrate the ability of some probiotic bacteria to interfere with the in vitro rotavirus infection in MA104 cells, strains of Lactobacillus sp...
April 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28422059/mismatch-between-probiotic-benefits-in-trials-versus-food-products
#3
Mary J Scourboutakos, Beatriz Franco-Arellano, Sarah A Murphy, Sheida Norsen, Elena M Comelli, Mary R L'Abbé
Probiotic food products contain a variety of different bacterial strains and may offer different health effects. The objective was to document the prevalence and dosage of probiotic strains in the Canadian food supply and to review the literature investigating these strains in order to understand what health benefits these products may offer. The Food Label Information Program was used to identify probiotic-containing products in the food supply. PubMed, Web of Science, and Embase were searched for randomized controlled trials that tested the health effects of these strains in humans...
April 19, 2017: Nutrients
https://www.readbyqxmd.com/read/28410580/lactobacillus-casei-dg-and-its-postbiotic-reduce-the-inflammatory-mucosal-response-an-ex-vivo-organ-culture-model-of-post-infectious-irritable-bowel-syndrome
#4
Debora Compare, Alba Rocco, Pietro Coccoli, Debora Angrisani, Costantino Sgamato, Barbara Iovine, Umberto Salvatore, Gerardo Nardone
BACKGROUND: The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotics exert their beneficial effects are largely unknown. The aim of the study is to evaluate the role of Lactobacillus casei DG (LC-DG) and its postbiotic (PB) in modulating the inflammatory/immune-response in PI-IBS in an ex-vivo organ culture model. METHODS: Ex vivo cultures of ileal and colonic mucosa from 10 PI-IBS, diarrhea predominant subtype (D) patients, and 10 healthy controls (HC) were treated with LPS, LC-DG and PB...
April 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28408779/effect-of-the-probiotic-lactobacillus-murinus-lbp2-on-clinical-parameters-of-dogs-with-distemper-associated-diarrhea
#5
Luis Delucchi, Martín Fraga, Pablo Zunino
The objective of this study was to assess the effect of the probiotic Lactobacillus murinus native strain (LbP2) on general clinical parameters of dogs with distemper-associated diarrhea. Two groups of dogs over 60 d of age with distemper and diarrhea were used in the study, which was done at the Animal Hospital of the Veterinary Faculty of the University of Uruguay, Montevideo, Uruguay. The dogs were treated orally each day for 5 d with the probiotic or with a placebo (vehicle without bacteria). Clinical parameters were assessed and scored according to a system specially designed for this study...
April 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28403547/effects-of-dietary-supplementation-with-a-probiotic-enterococcus-faecium-dsm-7134-on-growth-performance-nutrient-digestibility-and-gut-health-status-in-weaning-pigs
#6
R X Lan, I H Kim
BACKGROUND: Probiotics have been suggested as desirable antibiotic alternatives to pigs by improving gut health and growth performance. However, limited studies of the effectiveness of E. faecium in weaning pigs, the objective of this study was to investigate the effects of E. faecium DSM 7134 supplementation on growth performance, nutrient digestibility, antioxidant parameters, volatile fatty acids concentration, intestinal histomorphology, and diarrhea score in weaning pig. RESULTS: E...
April 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28396664/unraveling-the-differences-between-gram-positive-and-gram-negative-probiotics-in-modulating-protective-immunity-to-enteric-infections
#7
REVIEW
Sukumar Kandasamy, Anastasia N Vlasova, David D Fischer, Kuldeep S Chattha, Lulu Shao, Anand Kumar, Stephanie N Langel, Abdul Rauf, Huang-Chi Huang, Gireesh Rajashekara, Linda J Saif
The role of intestinal microbiota and probiotics in prevention and treatment of infectious diseases, including diarrheal diseases in children and animal models, is increasingly recognized. Intestinal commensals play a major role in development of the immune system in neonates and in shaping host immune responses to pathogens. Lactobacilli spp. and Escherichia coli Nissle 1917 are two probiotics that are commonly used in children to treat various medical conditions including human rotavirus diarrhea and inflammatory bowel disease...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28386253/current-and-potential-treatments-for-reducing-campylobacter-colonization-in-animal-hosts-and-disease-in-humans
#8
REVIEW
Tylor J Johnson, Janette M Shank, Jeremiah G Johnson
Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming under-cooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28383398/effect-of-probiotics-on-digestibility-and-immunity-in-infants-a-study-protocol-for-a-randomized-controlled-trial
#9
Lingli Xiao, Guodong Ding, Yifang Ding, Chaoming Deng, Xiaolei Ze, Liang Chen, Yao Zhang, Lihua Song, Hongli Yan, Fang Liu, Xiaoming Ben
The gastrointestinal (GI) tract of a fetus in utero is sterile but it becomes colonized with environmental microorganisms shortly after birth. Since the gut microbiota undergoes substantial changes in early life, healthy gut microflora is essential to an infant's gut health and immune system and probably also has an effect on overall health status in later life. Probiotics, defined as viable microbial preparations that have a beneficial effect on the health of the host, represent a rapidly expanding field. Although randomized controlled trials using probiotics in infants have shown promising results in the prevention and treatment of common diseases such as diarrhea and allergy, little is known about whether probiotics could offer benefits to healthy infants...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28346473/oral-administration-of-bifidobacterium-bifidum-g9-1-alleviates-rotavirus-gastroenteritis-through-regulation-of-intestinal-homeostasis-by-inducing-mucosal-protective-factors
#10
Tomohiro Kawahara, Yutaka Makizaki, Yosuke Oikawa, Yoshiki Tanaka, Ayako Maeda, Masaki Shimakawa, Satoshi Komoto, Kyoko Moriguchi, Hiroshi Ohno, Koki Taniguchi
Human rotavirus (RV) infection is a leading cause of dehydrating diarrhea in infants and young children worldwide. Since therapeutic approaches to RV gastroenteritis are limited to alleviation of dehydration with oral rehydration solutions, more direct approaches to palliate symptoms of RV gastroenteritis are required. Treatments with probiotics have been increasingly recognized as alternative safe and low cost treatments for moderate infectious diarrhea. In this study, Bifidobacterium bifidum G9-1 (BBG9-1), which has been used as an intestinal drug for several decades, was shown to have a remarkable protective effect against RV gastroenteritis in a suckling mice model...
2017: PloS One
https://www.readbyqxmd.com/read/28344124/comparative-genomics-of-transport-proteins-in-probiotic-and-pathogenic-escherichia-coli-and-salmonella-enterica-strains
#11
Jimmy Do, Hassan Zafar, Milton H Saier
Escherichia coli is a genetically diverse species that can be pathogenic, probiotic, commensal, or a harmless laboratory strain. Pathogenic strains of E. coli cause urinary tract infections, diarrhea, hemorrhagic colitis, and pyelonephritis, while the two known probiotic E. coli strains combat inflammatory bowel disease and play a role in immunomodulation. Salmonella enterica, a close relative of E. coli, includes two important pathogenic serovars, Typhi and Typhimurium, causing typhoid fever and enterocolitis in humans, respectively, with the latter strain also causing a lethal typhoid fever-like disease in mice...
March 24, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28337267/exploration-of-the-effect-of-probiotics-supplementation-on-intestinal-microbiota-of-food-allergic-mice
#12
Bo Yang, Liang Xiao, Sheng Liu, Xiaoyu Liu, Yan Luo, Qiongmei Ji, Pingchang Yang, Zhigang Liu
Environmental factor-induced alterations in intestinal microbiota have been demonstrated to be associated with increasing prevalence of food allergy. However, it is not clear to what extent oral administration of probiotics can affect gut microbiota composition, thus inhibiting food allergy development. Using ovalbumin (OVA)-sensitized murine model, it was demonstrated that probiotics ameliorated allergic symptoms, including reducing OVA specific-IgE, and -IgG1 levels in the serum, Th2 cytokines release in spleen, and occurrence of diarrhea...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28336969/complete-genome-sequence-and-comparative-genomics-of-the-probiotic-yeast-saccharomyces-boulardii
#13
Indu Khatri, Rajul Tomar, K Ganesan, G S Prasad, Srikrishna Subramanian
The probiotic yeast, Saccharomyces boulardii (Sb) is known to be effective against many gastrointestinal disorders and antibiotic-associated diarrhea. To understand molecular basis of probiotic-properties ascribed to Sb we determined the complete genomes of two strains of Sb i.e. Biocodex and unique28 and the draft genomes for three other Sb strains that are marketed as probiotics in India. We compared these genomes with 145 strains of S. cerevisiae (Sc) to understand genome-level similarities and differences between these yeasts...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321826/the-role-of-probiotics-in-the-treatment-of-dysentery-a-randomized-double-blind-clinical-trial
#14
Alireza Sharif, Hamed Haddad Kashani, Elahe Nasri, Zahra Soleimani, Mohammad Reza Sharif
Diarrhea is considered as an important cause of morbidity and mortality, even though one of the main reasons of death following diarrhea is initiated by dysentery. In recent years, the consumption of probiotics has been proposed for the treatment of infectious diarrhea. Despite most of the studies on probiotics have focused on acute watery diarrhea, few studies in the field of dysentery have found beneficial effects of probiotics. This study is a randomized double-blind clinical trial. The patients were randomly placed into control and case groups...
March 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28294071/safety-of-one-week-first-line-standard-triple-therapy-for-helicobacter-pylori-eradication-in-a-japanese-population
#15
Kazutoshi Hori, Tetsuya Takagawa, Nobuyuki Hida, Shiro Nakamura
BACKGROUND: Standard triple therapy with the proton pump inhibitors, clarithromycin and amoxicillin for Helicobacter pylori infection is considered to be safe; however, the development of significant adverse events (AEs), such as skin rashes, has been reported. OBJECTIVE: To reconfirm the safety of this treatment. METHODS: This was a retrospective cohort study. After the exclusion of patients allergic to penicillin, 322 consecutive patients, consisting of 305 outpatients and 17 inpatients, had received the first-line eradication treatment with lansoprazole (30 mg), clarithromycin (200 mg), and amoxicillin (750 mg) twice daily for 7 days...
March 9, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28289360/effect-of-probiotic-administration-in-the-therapy-of-pediatric-thermal-burn
#16
M H El-Ghazely, W H Mahmoud, M A Atia, E M Eldip
Oral probiotic administration has been advocated for treatment and prevention of a diverse range of disorders. This study was undertaken to evaluate the effect of probiotic supplementation on outcome of pediatric post-burn patients. Forty thermally-injured pediatric patients with total body surface burns between 20-50% and depth between 5-10% were randomized in a prospective, double-blind, controlled clinical trial into two even groups: probiotic group (n=20), who received probiotic preparations, and placebo control group (n=20)...
December 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28274108/small-intestinal-bacterial-overgrowth-and-irritable-bowel-syndrome-a-bridge-between-functional-organic-dichotomy
#17
REVIEW
Uday C Ghoshal, Ratnakar Shukla, Ujjala Ghoshal
The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is the realization that gut dysbiosis, including small intestinal bacterial overgrowth (SIBO), causes IBS symptoms. Between 4% and 78% of patients with IBS and 1% and 40% of controls have SIBO; such wide variations in prevalence might result from population differences, IBS diagnostic criteria, and, most importantly, methods to diagnose SIBO...
March 15, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28272692/gelatin-tannate-and-tyndallized-probiotics-a-novel-approach-for-treatment-of-diarrhea
#18
L Lopetuso, C Graziani, A Guarino, A Lamborghini, S Masi, V Stanghellini
OBJECTIVE: Intestinal permeability impairment is implicated in many gastrointestinal (GI) diseases. Chronic diarrhea, defined as the presence of diarrhea for more than 3 weeks in adults and 2 weeks in children, requires a different diagnostic and therapeutic work-up than acute diarrhea. Gelatin tannate, by reducing the clinical activity of acute colitis and the proinflammatory effects of lipopolysaccharide (LPS), is emerging as a mucosal barrier protector. MATERIALS AND METHODS: New therapeutic strategies focusing on the physiological function of the intestinal barrier, may offer an innovative approach for the clinical improvement of highly debilitating chronic GI diseases...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28271623/a-double-blind-placebo-controlled-study-to-assess-the-effect-of-a-probiotic-mixture-on-symptoms-and-inflammatory-markers-in-women-with-diarrhea-predominant-ibs
#19
K Hod, A D Sperber, Y Ron, M Boaz, R Dickman, S Berliner, Z Halpern, N Maharshak, R Dekel
BACKGROUND: Micro-inflammation is considered an element in the pathogenesis of irritable bowel syndrome (IBS). High-sensitivity C reactive protein (hs-CRP) was previously shown to be higher in IBS compared to healthy controls, albeit within the normal range. Since probiotics may suppress micro-inflammation in the gut, we tested if they reduce symptoms and inflammatory markers (hs-CRP and fecal calprotectin (FC) in diarrhea-predominant IBS (IBS-D). The aim of this study was to assess the clinical and laboratory effects of BIO-25, a multispecies probiotic, in women with IBS-D...
March 8, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28267992/clostridium-difficile-disease-diagnosis-pathogenesis-and-treatment-update
#20
REVIEW
Lena M Napolitano, Charles E Edmiston
Clostridium difficile infections are the leading cause of health care-associated infectious diarrhea, posing a significant risk for both medical and surgical patients. Because of the significant morbidity and mortality associated with C difficile infections, knowledge of the epidemiology of C difficile in combination with a high index of suspicion and susceptible patient populations (including surgical, postcolectomy, and inflammatory bowel disease patients) is warranted. C difficile infections present with a wide spectrum of disease, ranging from mild diarrhea to fulminant colitis or small bowel enteritis and recurrent C difficile infections...
March 3, 2017: Surgery
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