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https://www.readbyqxmd.com/read/28630638/cichorium-intybus-l-promotes-intestinal-uric-acid-excretion-by-modulating-abcg2-in-experimental-hyperuricemia
#1
Yu Wang, Zhijian Lin, Bing Zhang, Anzheng Nie, Meng Bian
BACKGROUND: Excessive production and/or reduced excretion of uric acid could lead to hyperuricemia, which could be a major cause of disability. Hyperuricemia has received increasing attention in the last few decades due to its global prevalence. Cichorium intybus L., commonly known as chicory, is a perennial herb of the asteraceae family. It was previously shown to exert potent hypouricemic effects linked with decreasing uric acid formation in the liver by down-regulating the activity of xanthine oxidase, and increasing uric acid excretion by up-regulating the renal OAT3 mRNA expression...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28629227/chemical-and-biological-studies-on-cichorium-intybus-l
#2
Dinara Satmbekova, Radhakrishnan Srivedavyasasri, Yerkebulan Orazbekov, Roza Omarova, Ubaidilla Datkhayev, Samir A Ross
Cichorium intybus L. (Asteraceae family) is a world-wide grown plant known as chicory. In traditional medicine, this plant is used as diuretic, anti-inflammatory, digestive, cardiotonic and liver tonic. Chromatographic purification of the supercritical fluid extract of aerial parts of C. intybus on silica gel column led to isolation of three compounds: new compound, 28β-hydroxytaraxasterol (I), and two known compounds usnic acid (II) and β-sitosterol (III). Purification of the ethanolic extract of aerial parts of this plant on silica gel column chromatography yielded four compounds: 1,3-dioleylglycerate (IV), sitoindoside II (V), 11β-13-dihydrolactucin (VI) and β-sitosterol-3-O-glucoside (VII)...
June 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28597952/efficacy-of-combined-sous-vide-microwave-cooking-for-foodborne-pathogen-inactivation-in-ready-to-eat-chicory-stems
#3
Massimiliano Renna, Maria Gonnella, Silvia de Candia, Francesco Serio, Federico Baruzzi
There is a variety of different food processing methods, which can be used to prepare ready-to-eat foods. However, the need to preserve the freshness and nutritional qualities leads to the application of mild technologies which may be insufficient to inactivate microbial pathogens. In this work, fresh chicory stems were packed under a vacuum in films, which were transparent to microwaves. These were then exposed to microwaves for different periods of time. The application of sous vide microwave cooking (SV-MW, 900 W, 2450 MHz), controlled naturally occurring mesophilic aerobic bacteria, yeasts and molds for up to 30 d when vacuum-packed vegetables were stored at 4 °C...
June 9, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28555924/physical-mechanical-characterization-of-cosmetic-formulations-and-correlation-between-instrumental-measurements-and-sensorial-properties
#4
Lívia Salomão Calixto, Patrícia M B G Maia Campos
OBJECTIVE: The correct choice of raw materials in the development of cosmetic formulations is essential for obtaining stable and pleasant skin care products. Therefore, rheological, texture and sensory analyses are important to understand the behavior and stability of the formulations. In this context, the aim of the present study was to develop cosmetic formulations containing or not (vehicle) UV filters and chicory root extract, to evaluate their stability as well as to characterize their physical and texture properties and correlate them with the sensory attributes...
May 28, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28509952/high-yield-production-of-mannitol-by-leuconostoc-pseudomesenteroides-ctcc-g123-from-chicory-derived-inulin-hydrolysate
#5
Min Zhang, Lei Gu, Chao Cheng, Junru Zhu, Hao Wu, Jiangfeng Ma, Weiliang Dong, Xiangping Kong, Min Jiang, Pingkai Ouyang
Chicory is an agricultural plant with considerable potential as a carbohydrate substrate for low-cost production of biochemicals. In this work, the production of mannitol by Leuconostoc pseudomesenteroides CTCC G123 from chicory-derived inulin hydrolysate was investigated. The bioconversion process initially suffered from the leakage of fructose to the phosphoketolase pathway, resulting in a low mannitol yield. When inulin hydrolysate was supplemented with glucose as a substrate for mannitol production in combination with aeration induction and nicotinic acid induced redox modulation strategies, the mannitol yield greatly improved...
May 16, 2017: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28465551/forbs-enhance-productivity-of-unfertilised-grass-clover-leys-and-support-low-carbon-bioenergy
#6
Wen-Feng Cong, Jingying Jing, Jim Rasmussen, Karen Søegaard, Jørgen Eriksen
Intensively managed grasslands are dominated by highly productive grass-clover mixtures. Increasing crop diversity by inclusion of competitive forbs may enhance biomass production and sustainable biofuel production. Here we examined if one or all of three forbs (chicory, Cichorium intybus L.; caraway, Carum carvi L.; plantain, Plantago lanceolata L.) included in ryegrass-red clover mixtures enhanced above- and below-ground productivity, and assessed their biofuel potentials, based on a three-year experiment with and without fertilisation as cattle slurry...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28452060/cimyb17-a-stress-induced-chicory-r2r3-myb-transcription-factor-activates-promoters-of-genes-involved-in-fructan-synthesis-and-degradation
#7
Hongbin Wei, Anja Bausewein, Steffen Greiner, Nicolas Dauchot, Karsten Harms, Thomas Rausch
In Cichorium intybus, inulin metabolism is mediated by fructan-active enzymes (FAZYs): sucrose:sucrose 1-fructosyltransferase (1-SST), fructan:fructan 1-fructosyltransferase (1-FFT), and fructan 1-exohydrolases 1, 2a and 2b (1-FEH1, -2a and -2b), respectively. While these enzymes have been rigorously characterized, the transcriptional network orchestrating their development- and stress-related expression has remained largely unknown. Here, the possible role of R2R3-MYB transcription factors in FAZY regulation was explored via bioinformatic identification of R2R3-MYBs (using an RNA sequencing (RNAseq) database), studies of co-expression of these factors with target genes, in vivo transient transactivation assays of FAZY target promoters (dual luciferase assay), and a yeast one-hybrid assay investigating the specificity of the binding of these factors to cis-elements...
April 28, 2017: New Phytologist
https://www.readbyqxmd.com/read/28441536/the-effect-of-forage-types-on-the-fatty-acid-profile-lipid-and-protein-oxidation-and-retail-colour-stability-of-muscles-from-white-dorper-lambs
#8
Gerlane F De Brito, Benjamin W B Holman, Shawn R McGrath, Michael A Friend, Remy van de Ven, David L Hopkins
The aim of this study was to evaluate the effect of different forage-types on lamb meat quality parameters. White Dorper lambs that had grazed five forage-types, were slaughtered commercially. At 24h post-mortem, the m. longissimus lumborum (LL) was removed from one side, sliced into three equal sub-samples, vacuum packaged and assigned to ageing periods (5, 12 or 40days); the other side of LL was aged for 5days. The m. adductor femoris was used for fatty acid analysis. Lambs fed chicory+arrowleaf clover had the highest concentration of health claimable omega-3 fatty acids and the lowest omega-6:omega-3 fatty acid ratio...
August 2017: Meat Science
https://www.readbyqxmd.com/read/28396680/corrigendum-insights-into-the-sesquiterpenoid-pathway-by-metabolic-profiling-and-de-novo-transcriptome-assembly-of-stem-chicory-cichorium-intybus-cultigroup-catalogna
#9
Giulio Testone, Giovanni Mele, Elisabetta Di Giacomo, Maria Gonnella, Massimiliano Renna, Gian Carlo Tenore, Chiara Nicolodi, Giovanna Frugis, Maria A Iannelli, Giuseppe Arnesi, Alessandro Schiappa, Donato Giannino
[This corrects the article on p. 1676 in vol. 7, PMID: 27877190.].
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28371117/structural-constraints-and-importance-of-caffeic-acid-moiety-for-anti-hyperglycemic-effects-of-caffeoylquinic-acids-from-chicory
#10
Kimberly M Palatini Jackson, Thirumurugan Rathinasabapathy, Debora Esposito, Slavko Komarnytsky
SCOPE: Chicory (Cichorium intybus L.) is a perennial herb often consumed as a vegetable, whereas the ground and roasted roots are blended as a coffee substitute. Caffeoylquinic or chlorogenic acids (CQA), the abundant intermediates of lignin biosynthesis in chicory, have been reported to improve glucose metabolism in humans, but the functional group in their structure responsible for this effect has not been yet characterized. METHODS AND RESULTS: Here, we showed that three di-O-caffeoylquinic acids suppressed hepatic glucose production in H4IIE rat hepatoma cells by reducing expression of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), two key enzymes that regulate hepatic gluconeogenesis...
April 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28341907/utilization-of-inulin-containing-waste-in-industrial-fermentations-to-produce-biofuels-and-bio-based-chemicals
#11
REVIEW
Stephen R Hughes, Nasib Qureshi, Juan Carlos López-Núñez, Marjorie A Jones, Joshua M Jarodsky, Luz Ángela Galindo-Leva, Mitchell R Lindquist
Inulins are polysaccharides that belong to an important class of carbohydrates known as fructans and are used by many plants as a means of storing energy. Inulins contain 20 to several thousand fructose units joined by β-2,1 glycosidic bonds, typically with a terminal glucose unit. Plants with high concentrations of inulin include: agave, asparagus, coffee, chicory, dahlia, dandelion, garlic, globe artichoke, Jerusalem artichoke, jicama, onion, wild yam, and yacón. To utilize inulin as its carbon and energy source directly, a microorganism requires an extracellular inulinase to hydrolyze the glycosidic bonds to release fermentable monosaccharides...
April 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28337581/high-lactic-acid-and-fructose-production-via-mn-2-mediated-conversion-of-inulin-by-lactobacillus-paracasei
#12
Kaloyan Petrov, Luiza Popova, Penka Petrova
Lactobacillus paracasei DSM 23505 is able to produce high amounts of lactic acid (LA) by simultaneous saccharification and fermentation (SSF) of inulin. Aiming to obtain the highest possible amounts of LA and fructose, the present study is devoted to evaluate the impact of bivalent metal ions on the process of inulin conversion. It was shown that Mn(2+) strongly increases the activity of the purified key enzyme β-fructosidase. In vivo, batch fermentation kinetics revealed that the high Mn(2+) concentrations accelerated inulin hydrolysis by raise of the inulinase activity, and increased sugars conversion to LA through enhancement of the whole glycolytic flux...
March 23, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28293641/functional-effects-of-prebiotic-fructans-in-colon-cancer-and-calcium-metabolism-in-animal-models
#13
Marisol Rivera-Huerta, Vania Lorena Lizárraga-Grimes, Ibrahim Guillermo Castro-Torres, Mabel Tinoco-Méndez, Lucía Macías-Rosales, Francisco Sánchez-Bartéz, Graciela Guadalupe Tapia-Pérez, Laura Romero-Romero, María Isabel Gracia-Mora
Inulin-type fructans are polymers of fructose molecules and are known for their capacity to enhance absorption of calcium and magnesium, to modulate gut microbiota and energy metabolism, and to improve glycemia. We evaluated and compared the effects of Chicory inulin "Synergy 1®" and inulin from Mexican agave "Metlin®" in two experimental models of colon cancer and bone calcium metabolism in mice and rats. Inulins inhibited the development of dextran sulfate sodium-induced colitis and colon cancer in mice; these fructans reduced the concentration of tumor necrosis factor alpha and prevented the formation of intestinal polyps, villous atrophy, and lymphoid hyperplasia...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28264014/retraction-chicory-cichorium-intybus-l-root-extract-regulates-the-oxidative-status-and-antioxidant-gene-transcripts-in-ccl4-induced-hepatotoxicity
#14
Yasser S El-Sayed, Mohamed A Lebda, Mohammed Hassinin, Saad A Noeman
No abstract text is available yet for this article.
2017: PloS One
https://www.readbyqxmd.com/read/28255654/replacement-of-glycaemic-carbohydrates-by-inulin-type-fructans-from-chicory-oligofructose-inulin-reduces-the-postprandial-blood-glucose-and-insulin-response-to-foods-report-of-two-double-blind-randomized-controlled-trials
#15
Helen Lightowler, Sangeetha Thondre, Anja Holz, Stephan Theis
PURPOSE: Inulin-type fructans are recognized as prebiotic dietary fibres and classified as non-digestible carbohydrates that do not contribute to glycaemia. The aim of the present studies was to investigate the glycaemic response (GR) and insulinaemic response (IR) to foods in which sucrose was partially replaced by inulin or oligofructose from chicory. METHODS: In a double-blind, randomized, controlled cross-over design, 40-42 healthy adults consumed a yogurt drink containing oligofructose or fruit jelly containing inulin and the respective full-sugar variants...
March 3, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28218451/specific-inulin-type-fructan-fibers-protect-against-autoimmune-diabetes-by-modulating-gut-immunity-barrier-function-and-microbiota-homeostasis
#16
Kang Chen, Hao Chen, Marijke M Faas, Bart J de Haan, Jiahong Li, Ping Xiao, Hao Zhang, Julien Diana, Paul de Vos, Jia Sun
SCOPE: Dietary fibers capable of modifying gut barrier and microbiota homeostasis, affect the progression of type 1 diabetes (T1D). Here we aim to compare modulatory effects of inulin-type fructans (ITFs), natural soluble dietary fibers with different degrees of fermentability from chicory root, on T1D development in non-obese diabetic (NOD) mice. METHODS AND RESULTS: Female NOD mice were weaned to long and short chain ITFs [ITF(l) and ITF(s), 5%] supplemented diet up to 24 weeks...
February 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28105758/chicory-inulin-ameliorates-type-2-diabetes-mellitus-and-suppresses-jnk-and-mapk-pathways-in-vivo-and-in-vitro
#17
Chong Ning, Xiyao Wang, Song Gao, Jingjing Mu, Yuehua Wang, Suwen Liu, Jinyan Zhu, Xianjun Meng
SCOPE: Chicory inulin is a naturally occurring fructan that is conducive to glucose and lipid metabolism in patients with diabetes mellitus. The present study aims to investigate the mechanism by which chicory inulin improves glucolipid metabolism in diabetic conditions. METHODS AND RESULTS: Rats were injected with streptozotocin and fed with high fat diet to induce diabetes, and then administrated with different doses of chicory inulin for 8 weeks. The glycometabolism and lipid metabolism parameters were determined, the activity of insulin receptor substrate (IRS) and mitogen-activated protein kinase (MAPK) pathways were examined by western blot...
January 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28089212/does-particulate-matter-along-roadsides-interfere-with-plant-reproduction-a-comparison-of-effects-of-different-road-types-on-cichorium-intybus-pollen-deposition-and-germination
#18
COMPARATIVE STUDY
Susan Y Jaconis, Theresa M Culley, Alexandra M Meier
The roadside habitat can be challenging for plants, which must maintain normal biological processes despite an influx of airborne pollutants. While the effects of many gases on plants have been quantified, the impacts of particulate pollutants have been relatively less studied. This is especially true of field experiments where particle dispersion may be influenced by meteorology and roadway use. We examined chicory (Cichorium intybus L.) along roadsides in the Cincinnati, Ohio metropolitan area to assess particulate influence on plant pollination through stigmatic clogging...
March 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28011163/lactucopicrin-potentiates-neuritogenesis-and-neurotrophic-effects-by-regulating-ca-2-camkii-atf1-signaling-pathway
#19
Ramu Venkatesan, Won-Sik Shim, Eui-Ju Yeo, Sun Yeou Kim
ETHNO-PHARMACOLOGICAL RELEVANCE: Lactucopicrin is one of constitutes in Cichorium intybus L, which is commonly known as chicory in worldwide. It has been used for traditional usage such as antianalgesics, antidepressants and antihyperglycemics. AIM OF STUDY: We investigated the neurotrophin-mediated neuroprotective effect of lactucopicrin in in vitro and examined for the underlying mechanism. MATERIALS AND METHOD: To verify the neuroprotective effect of lactucopicrin, we investigated the inhibitory AChE activity, neurite outgrowth-related downstream signaling in murine neuroblastoma N2a and neurotrophins secretion in rat C6 glioma cells...
December 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28003341/chicoric-acid-supplementation-prevents-systemic-inflammation-induced-memory-impairment-and-amyloidogenesis-via-inhibition-of-nf-%C3%AE%C2%BAb
#20
Qian Liu, Yuwei Chen, Chun Shen, Yating Xiao, Yutang Wang, Zhigang Liu, Xuebo Liu
Chicoric acid (CA), a natural phenolic acid extracted from chicory and the echinacea (purple coneflower) plant (Echinacea purpurea), has been regarded as a nutraceutical that has powerful antioxidant and antiobesity activities. We investigated the inhibitory effects of CA on systemic inflammation-induced neuroinflammation, amyloidogenesis, and cognitive impairment. C57BL/6J mice were treated with 0.05% CA in the drinking water for 45 d. The mice were then treated by intraperitoneal injection of LPS (lipopolysaccharide)...
December 21, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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