Ryan G Walker, Ornella Barrandon, Tommaso Poggioli, Sezin Dagdeviren, Shannon H Carroll, Melanie J Mills, Kourtney R Mendello, Yanet Gomez, Francesco S Loffredo, James R Pancoast, Claudio Macias-Trevino, Colin Marts, Katherine B LeClair, Hye-Lim Noh, Taekyoon Kim, Alexander S Banks, Jason K Kim, David E Cohen, Amy J Wagers, Douglas A Melton, Richard T Lee
Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protein GDF8 has a role in metabolism, limited data are available on the potential metabolic effects of GDF11 or GDF8 in aging. To determine the metabolic effects of these two ligands, we administered rGDF11 or rGDF8 protein to young or aged mice fed a standard chow diet, short-term high-fat diet (HFD), or long-term HFD...
March 12, 2020: Scientific Reports