Amena Keshawarz, Roby Joehanes, Jiantao Ma, Gha Young Lee, Ricardo Costeira, Pei-Chien Tsai, Olatz M Masachs, Jordana T Bell, Rory Wilson, Barbara Thorand, Juliane Winkelmann, Annette Peters, Jakob Linseisen, Melanie Waldenberger, Terho Lehtimäki, Pashupati P Mishra, Mika Kähönen, Olli Raitakari, Mika Helminen, Carol A Wang, Phillip E Melton, Rae-Chi Huang, Craig E Pennell, Therese A O'Sullivan, Carolina Ochoa-Rosales, Trudy Voortman, Joyce B J van Meurs, Kristin L Young, Misa Graff, Yujie Wang, Douglas P Kiel, Caren E Smith, Paul F Jacques, Daniel Levy
BACKGROUND: Dietary intake of antioxidants such as vitamins C and E protect against oxidative stress, and may also be associated with altered DNA methylation patterns. METHODS: We meta-analysed epigenome-wide association study (EWAS) results from 11,866 participants across eight population-based cohorts to evaluate the association between self-reported dietary and supplemental intake of vitamins C and E with DNA methylation. EWAS were adjusted for age, sex, BMI, caloric intake, blood cell type proportion, smoking status, alcohol consumption, and technical covariates...
December 2023: Epigenetics: Official Journal of the DNA Methylation Society