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https://www.readbyqxmd.com/read/28214312/update-treatment-of-necrobiosis-lipoidica
#1
REVIEW
Melanie Peckruhn, Jörg Tittelbach, Peter Elsner
Necrobiosis lipoidica (NL) is a rare granulomatous disease of hitherto unclear etiology frequently seen in patients with diabetes. Characterized by its potential for ulcerations, it often presents a serious burden for those affected. There are currently neither German nor European guidelines for the treatment of NL. At the same time, standard treatment with topical or intralesional corticosteroids does not always show satisfactory results. We therefore set out to evaluate whether the various treatment regimens published since 2000 have actually expanded the therapeutic armamentarium in a relevant manner...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28208752/meta-analysis-on-the-association-of-aldh2-polymorphisms-and-type-2-diabetic-mellitus-diabetic-retinopathy
#2
Guang-Yi Li, Zi-Bo Li, Fang Li, Li-Ping Dong, Liang Tang, Ju Xiang, Jian-Ming Li, Mei-Hua Bao
Type 2 diabetic mellitus (T2DM) is a disease with high prevalence and a major cause for death worldwide. Diabetic retinopathy (DR) is one of the major manifestation of diabetes. Aldehyde dehydrogenease 2 (ALDH2) detoxifies aldehyde produced during ethanol metabolism and oxidative stress. It has been found that the polymorphism in ALDH2 rs671 is probably associated with the risk of T2DM and DR. However, a lot of inconsistency and controversy still exists. In order to get a more precise and comprehensive estimation for the association between ALDH2 polymorphism with the risk of T2DM and DR, we conducted the present meta-analysis...
February 8, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28207831/the-relationship-between-rassf1a-gene-promoter-methylation-and-the-susceptibility-and-prognosis-of-melanoma-a-meta-analysis-and-bioinformatics
#3
Chihao Shao, Wenzhu Dai, Haili Li, Wenru Tang, Shuting Jia, Xiaoming Wu, Ying Luo
BACKGROUND: The function of the tumor suppressor gene RASSF1A in cancer cells has been detailed in many studies. However, due to the methylation of its promoter, the expression of RASSF1A is missing in most cancers. In the literature, we found that the conclusion regarding the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma was not unified. This study adopts the use of a meta-analysis and bioinformatics to explore the relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma...
2017: PloS One
https://www.readbyqxmd.com/read/28202945/left-ventricular-hypertrophy-in-association-with-cognitive-impairment-a-systematic-review-and-meta-analysis
#4
Marios K Georgakis, Andreas Synetos, Constantinos Mihas, Maria A Karalexi, Dimitrios Tousoulis, Sudha Seshadri, Eleni Th Petridou
Left ventricular hypertrophy (LVH) is a marker of prolonged exposure to high blood pressure and a predictor of cardiovascular disease risk. The objective of the current study was to investigate its association with cognitive function. Following standard guidelines, pairs of independent reviewers screened 2359 articles to search for studies that addressed the research question, extracted data and evaluated the quality of the studies using the Newcastle-Ottawa scale; authors were contacted for additional data...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28196953/prevalence-and-patterns-of-congenital-heart-diseases-in-africa-a-systematic-review-and-meta-analysis-protocol
#5
Aurel T Tankeu, Jean Joel R Bigna, Jobert Richie N Nansseu, Leopold Ndemnge Aminde, Celestin Danwang, Mazou N Temgoua, Jean Jacques N Noubiap
INTRODUCTION: Congenital heart diseases (CHD) are common causes of cardiovascular morbidity and mortality among young children and adolescents living in Africa. Accurate epidemiological data are needed in order to evaluate and improve preventive strategies. This review aims to determine the prevalence of CHD and their main patterns in Africa. METHODS AND ANALYSIS: This systematic review and meta-analysis will include cross-sectional, case-control and cohort studies of populations residing inside African countries, which have reported the prevalence of CHD, confirmed by an echocardiographic examination and/or describing different patterns of these abnormalities in Africa...
February 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/28196543/the-3-dimensional-miniplate-is-more-effective-than-the-standard-miniplate-for-the-management-of-mandibular-fractures-a-meta-analysis
#6
Yong Liu, Bo Wei, Yuxiang Li, Dawei Gu, Guochao Yin, Bo Wang, Dehui Xu, Xuebing Zhang, Daliang Kong
PURPOSE: The study aimed to determine the superiority between 3-dimensional (3D) miniplate and standard miniplate for mandibular fractures (MFs) treatment. BACKGROUND: Controversial results on the use of standard miniplate and 3D miniplate have remained for management of MFs. METHODS: Several electronic databases were retrieved up to September 2014 to identify eligible studies. The quality of studies was assessed, and the relative risk (RR) with its corresponding 95% confidence interval (CI) was assessed to measure the effect size...
February 14, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28196329/breastfeeding-mode-and-risk-of-breast-cancer
#7
Mishel Unar-Munguía, Gabriela Torres-Mejía, M Arantxa Colchero, Teresita González de Cosío
BACKGROUND: Breastfeeding reduces women's risk of breast cancer. Since exclusive breastfeeding has a stronger hormonal effect, it could theoretically result in a greater reduction in breast cancer risk than any breastfeeding mode. No meta-analysis has examined breast cancer risk by breastfeeding mode. Research aim: The authors conducted a meta-analysis for breast cancer risk in parous women who breastfed exclusively or in any mode versus parous women who formula fed their infants, and they estimated the summary dose-response association by the accumulated duration of any breastfeeding mode...
February 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28192600/systematic-reviews-and-meta-analyses-on-psoriasis-role-of-funding-sources-conflict-of-interest-and-bibliometric-indices-as-predictors-of-methodological-quality
#8
F Gómez-García, J Ruano, M Aguilar-Luque, J Gay-Mimbrera, B Maestre-Lopez, J L Sanz-Cabanillas, P J Carmona-Fernández, M González-Padilla, A Vélez García-Nieto, B Isla-Tejera
BACKGROUND: The quality of systematic reviews (SRs) and meta-analyses about psoriasis, a chronic inflammatory skin disease that severely impairs quality of life and is associated with high costs, remains unknown. OBJECTIVES: To assess the methodological quality of SRs published on psoriasis. METHODS: After a comprehensive search in MEDLINE, EMBASE, and the Cochrane Database (PROSPERO:CDR4201604161), the quality was assessed by two raters using Assessment of Multiple Systematic Reviews (AMSTAR) tool...
February 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28190464/a-chinese-patent-medicine-salvia-miltiorrhiza-depside-salts-for-infusion-combined-with-conventional-treatment-for-patients-with-angina-pectoris-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Yili Zhang, Yanming Xie, Xing Liao, Qiulei Jia, Yan Chai
BACKGROUND: Currently, many trials have been conducted to investigate the beneficial and harmful effects of Salvia miltiorrhiza depside salts for infusion for treating patients with angina pectoris. It is important to systematically and criticallyevaluate the existing literature into providing a pooled effect to examine outcomes of angina pectoris with Salvia miltiorrhiza depside salts for infusion. PURPOSE: A systematic review and meta-analysis were performed to determine the clinical curative effect and safety of Salvia miltiorrhiza depside salts for infusion for angina pectoris and provide clear evidence to inform clinical practice...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28186338/research-review-language-problems-in-children-with-attention-deficit-hyperactivity-disorder-a-systematic-meta-analytic-review
#10
REVIEW
Hannah Korrel, Kathryn L Mueller, Tim Silk, Vicki Anderson, Emma Sciberras
BACKGROUND: Children with Attention-Deficit Hyperactivity Disorder (ADHD) appear to have a higher risk of language problems compared with typically developing children, although the types of language problems experienced are less clear. This review aims to establish the types of language problems experienced by children with ADHD according to systematically reviewed literature and determine the empirical evidence for language problems in children with ADHD compared with non-ADHD controls...
February 10, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28185144/complications-and-thromboembolic-events-associated-with-tamoxifen-therapy-in-patients-with-breast-cancer-undergoing-microvascular-breast-reconstruction-a-systematic-review-and-meta-analysis
#11
REVIEW
Rajiv P Parikh, Elizabeth B Odom, Liyang Yu, Graham A Colditz, Terence M Myckatyn
PURPOSE: Tamoxifen therapy is integral in the treatment of patients with hormone receptor-positive breast cancer. However, there is an association between tamoxifen and thromboembolic events. Flap and systemic thromboembolic events have devastating consequences in microvascular breast reconstruction. Currently, there are conflicting data on the association between tamoxifen therapy and thromboembolic complications for patients undergoing microvascular breast reconstruction. The objective of this study is to determine if perioperative tamoxifen therapy modifies the risk of complications and thromboembolic events for patients with breast cancer undergoing microvascular breast reconstruction...
February 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28183787/prognostic-significance-of-diffuse-sclerosing-variant-papillary-thyroid-carcinoma-a-systematic-review-and-meta-analysis
#12
Huy Gia Vuong, Tetsuo Kondo, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
OBJECTIVE: Diffuse sclerosing variant papillary thyroid carcinoma (DSVPTC) is an uncommon variant of papillary thyroid carcinoma (PTC). The biological behaviors and prognostic outcomes of this variant, however, are still controversial. The aim of this systematic review and meta-analysis is to investigate the prognostic significance and outcomes of DSVPTCs in comparison with classical PTCs (cPTCs). METHODS: An electronic search was performed in five libraries: PubMed, Scopus, ISI, World Health Organization Global Health Library (WHO GHL) and Virtual Health Library (VHL) in June 2016...
April 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28182585/anesthetic-neuroprotection-in-experimental-stroke-in-rodents-a-systematic-review-and-meta-analysis
#13
David P Archer, Andrew M Walker, Sarah K McCann, Joanna J Moser, Ramana M Appireddy
BACKGROUND: Patients undergoing endovascular therapy for acute ischemic stroke may require general anesthesia to undergo the procedure. At present, there is little clinical evidence to guide the choice of anesthetic in this acute setting. The clinical implications of experimental studies demonstrating anesthetic neuroprotection are poorly understood. Here, the authors evaluated the impact of anesthetic treatment on neurologic outcome in experimental stroke. METHODS: Controlled studies of anesthetics in stroke using the filament occlusion model were identified in electronic databases up to December 15, 2015...
February 9, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28182460/lying-takes-time-a-meta-analysis-on-reaction-time-measures-of-deception
#14
Kristina Suchotzki, Bruno Verschuere, Bram Van Bockstaele, Gershon Ben-Shakhar, Geert Crombez
Lie detection techniques are frequently used, but most of them have been criticized for the lack of empirical support for their predictive validity and presumed underlying mechanisms. This situation has led to increased efforts to unravel the cognitive mechanisms underlying deception and to develop a comprehensive theory of deception. A cognitive approach to deception has reinvigorated interest in reaction time (RT) measures to differentiate lies from truths and to investigate whether lying is more cognitively demanding than truth telling...
February 9, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28181444/-just-think-positive-we-can-all-work-to-address-the-publication-bias-issue
#15
David Berle
No abstract text is available yet for this article.
February 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28181214/aspirin-single-dose-for-perineal-pain-in-the-early-postpartum-period
#16
REVIEW
Sujana Molakatalla, Emily Shepherd, Rosalie M Grivell
BACKGROUND: Perineal trauma (due to spontaneous tears, surgical incision (episiotomy) or in association with operative vaginal birth) is common after vaginal birth, and is often associated with postpartum perineal pain. Birth over an intact perineum may also lead to perineal pain. There are adverse health consequences associated with perineal pain for the women and their babies in the short- and long-term, and the pain may interfere with newborn care and the establishment of breastfeeding...
February 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28178665/prognostic-value-of-glut-1-expression-in-pancreatic-cancer-results-from-538-patients
#17
Gaowa Sharen, Yaojun Peng, Haidong Cheng, Yang Liu, Yonghong Shi, Jian Zhao
OBJECTIVE: Previous studies have suggested a correlation between glucose transporter-1 (GLUT-1) expression and survival outcomes in pancreatic cancer, although the results were inconsistent. We subsequently carried out a meta-analysis, with the aim of comprehensively reevaluating the associations between GLUT-1 expression and overall survival (OS) and other clinical features of pancreatic cancer. RESULTS: Eight studies, with a total of 538 cases, were included in the final meta-analysis...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28178287/herpes-zoster-and-the-risk-of-ischemic-and-hemorrhagic-stroke-a-systematic-review-and-meta-analysis
#18
Ying Lian, Yun Zhu, Fang Tang, Bing Yang, Ruisheng Duan
BACKGROUND: Herpes zoster infection and stroke are highly prevalent in the general population; however, reports have presented inconsistent findings regarding the relationship between herpes zoster infection and stroke. In this meta-analysis, we aimed to clarify this association. MATERIAL AND METHODS: The PubMed and Embase databases were searched for studies published from their inception to January 2016. Two investigators independently extracted the data. The pooled relative risk (RR) was calculated using a random effects model...
2017: PloS One
https://www.readbyqxmd.com/read/28178139/epstein-barr-virus-is-associated-with-periodontal-diseases-a-meta-analysis-based-on-21-case-control-studies
#19
Zilong Gao, Juan Lv, Min Wang
Some controversies still exist between the detection of Epstein-Barr virus (EBV)'s DNA and risks of periodontal diseases. Hence, a comprehensive meta-analysis on all available literatures was performed to clarify the relationship between EBV and preidontitis.A comprehensive search was conducted within the PUBMED, EMBASE, and WANFANG databases up to October 10th, 2016 according to inclusion and exclusion criteria and finally 21 case-control literatures were obtained. The outcomes including odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28177181/radial-endobronchial-ultrasound-for-the-diagnosis-of-peripheral-pulmonary-lesions-a-systematic-review-and-meta-analysis
#20
REVIEW
Muhammad S Ali, William Trick, Benjamin I Mba, Divyanshu Mohananey, Jaskaran Sethi, Ali I Musani
Tissue diagnosis of peripheral pulmonary lesions (PPLs) can be challenging. In the past, flexible bronchoscopy was commonly performed for this purpose but its diagnostic yield is suboptimal. This has led to the development of new bronchoscopic modalities such as radial endobronchial ultrasound (R-EBUS), electromagnetic navigation bronchoscopy (ENB) and virtual bronchoscopy (VB). We performed this meta-analysis using data from previously published R-EBUS studies, to determine its diagnostic yield and other performance characteristics...
February 8, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
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