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https://www.readbyqxmd.com/read/28343269/neophobia-is-negatively-related-to-reversal-learning-ability-in-females-of-a-generalist-bird-of-prey-the-chimango-caracara-milvago-chimango
#1
Jorgelina María Guido, Laura Marina Biondi, Aldo Ivan Vasallo, Rubén Nestor Muzio
In an ever-changing environment, the ability to adapt choices to new conditions is essential for daily living and ultimately, for survival. Behavioural flexibility allows animals to maximise survival and reproduction in novel settings by adjusting their behaviour based on specific information and feedback acquired in their current environments. However, a growing body of evidence indicates that an individual's personality type can limit the extent to which the individual might behave flexibly, by influencing the way an individual pays attention to novelty and how much information it collects and stores, which in turn affects the individual's decision-making and learning process...
March 25, 2017: Animal Cognition
https://www.readbyqxmd.com/read/28343239/improved-full-length-killer-cell-immunoglobulin-like-receptor-transcript-discovery-in-mauritian-cynomolgus-macaques
#2
Trent M Prall, Michael E Graham, Julie A Karl, Roger W Wiseman, Adam J Ericsen, Muthuswamy Raveendran, R Alan Harris, Donna M Muzny, Richard A Gibbs, Jeffrey Rogers, David H O'Connor
Killer cell immunoglobulin-like receptors (KIRs) modulate disease progression of pathogens including HIV, malaria, and hepatitis C. Cynomolgus and rhesus macaques are widely used as nonhuman primate models to study human pathogens, and so, considerable effort has been put into characterizing their KIR genetics. However, previous studies have relied on cDNA cloning and Sanger sequencing that lack the throughput of current sequencing platforms. In this study, we present a high throughput, full-length allele discovery method utilizing Pacific Biosciences circular consensus sequencing (CCS)...
March 25, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28343208/legal-features-of-the-drug-advertising
#3
Vitalii M Pashkov, Andrii A Olefir, Oleksiy Y Bytyak
INTRODUCTION: In the article discribed current trends of advertising in the pharmaceutical market and foreign experience of legal regulation of these relations. As for the advertising of medicines identified it's symptoms, types, basic rules and prohibitions. Modern pharmaceutical companies can not successfully carry out economic activities without advertising. Besides we can mention some fundamental changes in society (information overload, universal access to internet, social media, freedom of movement of goods, labor and finance), also self-medication becomes more popular...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28343184/regulatory-role-of-ngfs-in-neurocognitive-functions
#4
Ashutosh Kumar, Vikas Pareek, Muneeb A Faiq, Pavan Kumar, Khursheed Raza, Pranav Prasoon, Subrahamanyam Dantham, Sankat Mochan
Nerve growth factors (NGFs), especially the prototype NGF and brain-derived neurotrophic factor (BDNF), have a diverse array of functions in the central nervous system through their peculiar set of receptors and intricate signaling. They are implicated not only in the development of the nervous system but also in regulation of neurocognitive functions like learning, memory, synaptic transmission, and plasticity. Evidence even suggests their role in continued neurogenesis and experience-dependent neural network remodeling in adult brain...
March 27, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28343133/single-crystal-cr2o3-nanoplates-with-differing-crystalinities-derived-from-trinuclear-complexes-and-embedded-in-a-carbon-matrix-as-an-electrode-material-for-supercapacitors
#5
Jikui Zhu, Yuqian Jiang, Zhiyong Lu, Chenglan Zhao, Li Xie, Lingyun Chen, Jingui Duan
As one kind of important p-type semiconductors, Cr2O3 has been widely used for optical and electronic devices due to its high electrical conductivity and special optoelectronic characteristics, as well as high chemical and thermal stability. In this paper, single-crystalline Cr2O3 nanoplates embedded in carbon matrix were successfully synthesized through direct thermal decomposition of a trinuclear cluster complex of [Cr3O(CH3CO2)6(H2O)3]NO3·CH3COOH ([Cr3O]) in Ar atmosphere. The synergetic effect of the plate-like structure and embedding in carbon matrix contributes to the enhanced electrochemical performance of the Cr2O3-C nanoplates...
March 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28343035/evaluation-of-4-methylcyclohexanemethanol-mchm-in-a-combined-irritatancy-and-local-lymph-node-assay-llna-in-mice
#6
Victor J Johnson, Scott S Auerbach, Michael I Luster, Suramya Waidyanatha, Scott A Masten, Mary S Wolfe, Florence G Burleson, Gary R Burleson, Dori R Germolec
4-Methylcyclohexanemethanol (MCHM) is a flotation reagent used in fine coal beneficiation. On January 9, 2014, crude MCHM, a mixture containing predominantly MCHM, was inadvertently released into the Elk River, a municipal water source that serves about 300,000 people in the Charleston, WV area, resulting in temporary contamination of 15 percent of the state's tap water and causing significant dermal exposure. The current studies were undertaken to determine whether crude MCHM or MCHM has the potential to produce dermal irritancy and/or sensitization...
March 22, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28343028/epidemiology-of-penetrating-injuries-in-the-united-kingdom-a-systematic-review
#7
REVIEW
G Whittaker, J Norton, J Densley, D Bew
INTRODUCTION: Penetrating injuries account for a significant number of deaths in the United Kingdom (UK) annually. Numerous articles have examined the epidemiology of penetrating trauma in various areas of the UK. This article aimed to systematically review the current literature and evaluate the incidence and mortality of penetrating injury according to region in the UK. METHODS: A systematic literature search was performed using MEDLINE(®) (1946 to June 2016), EMBASE(®) (1974 to June 2016), and PsycINFO(®) (1806 to June 2016) databases...
March 22, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28342890/vasodilatory-effect-of-nitroglycerin-in-japanese-subjects-with-different-aldehyde-dehydrogenase-2-aldh2-genotypes
#8
Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Kazuya Yonezawa
The functional genetic polymorphism of aldehyde dehydrogenase 2 (ALDH2) influences the enzymatic activities of its wild type (Glu504 encoded by ALDH2*1) and mutant type (Lys504 encoded by ALDH2*2) proteins. The enzymatic activities of mutant-type ALDH2 are limited compared with those of the wild type. ALDH2 has been suggested as a critical factor for nitroglycerin-mediated vasodilation by some human studies and in vitro studies. Currently, there is no research on direct observations of the vasodilatory effect of nitroglycerin sublingual tablets, which is the generally used dosage form...
March 23, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28342879/stable-subcutaneous-cartilage-regeneration-of-bone-marrow-stromal-cells-directed-by-chondrocyte-sheet
#9
Dan Li, Lian Zhu, Yu Liu, Zongqi Yin, Yi Liu, Fangjun Liu, Aijuan He, Shaoqing Feng, Yixin Zhang, Zhiyong Zhang, Wenjie Zhang, Wei Liu, Yilin Cao, Guangdong Zhou
In vivo niche plays an important role in regulating differentiation fate of stem cells. Due to lack of proper chondrogenic niche, stable cartilage regeneration of bone marrow stromal cells (BMSCs) in subcutaneous environments is always a great challenge. This study explored the feasibility that chondrocyte sheet created chondrogenic niche retained chondrogenic phenotype of BMSC engineered cartilage (BEC) in subcutaneous environments. Porcine BMSCs were seeded into biodegradable scaffolds followed by 4 weeks of chondrogenic induction in vitro to form BEC, which were wrapped with chondrocyte sheets (Sheet group), acellular small intestinal submucosa (SIS, SIS group), or nothing (Blank group) respectively and then implanted subcutaneously into nude mice to trace the maintenance of chondrogenic phenotype...
March 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28342842/protectin-dx-suppresses-hepatic-gluconeogenesis-through-ampk-ho-1-mediated-inhibition-of-er-stress
#10
Tae Woo Jung, Hyung-Chun Kim, Ji Hoon Jeong
Several studies have shown that protectins, which are ω-3 fatty acid-derived proresolution mediators, may improve insulin resistance. Recently, protectin DX (PDX) was documented to attenuate insulin resistance by stimulating IL-6 expression in skeletal muscle, thereby regulating hepatic gluconeogenesis. These findings made us investigate the direct effects of PDX on hepatic glucose metabolism in the context of diabetes. In the current study, we show that PDX regulates hepatic gluconeogenesis in a manner distinct from its indirect glucoregulatory activity via IL-6...
March 22, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28342799/lost-in-processing-perceived-healthfulness-taste-and-caloric-content-of-whole-and-processed-organic-food
#11
Marília Prada, Margarida V Garrido, David Rodrigues
The "organic" claim explicitly informs consumers about the food production method. Yet, based on this claim, people often infer unrelated food attributes. The current research examined whether the perceived advantage of organic over conventional food generalizes across different organic food types. Compared to whole organic foods, processed organic foods are less available, familiar and prototypical of the organic food category. In two studies (combined N = 258) we investigated how both organic foods types were perceived in healthfulness, taste and caloric content when compared to their conventional alternatives...
March 23, 2017: Appetite
https://www.readbyqxmd.com/read/28342780/a-neural-basis-for-the-visual-sense-of-number-and-its-development-a-steady-state-visual-evoked-potential-study-in-children-and-adults
#12
Joonkoo Park
While recent studies in adults have demonstrated the existence of a neural mechanism for a visual sense of number, little is known about its development and whether such a mechanism exists at young ages. In the current study, I introduce a novel steady-state visual evoked potential (SSVEP) technique to objectively quantify early visual cortical sensitivity to numerical and non-numerical magnitudes of a dot array. I then examine this neural sensitivity to numerical magnitude in children between three and ten years of age and in college students...
March 2, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28342743/measurement-of-ion-fluxes-across-epithelia
#13
REVIEW
Miroslaw Zajac, Krzysztof Dolowy
Epithelial tissues line all wet surfaces of vertebrate bodies. Their major function is directional transport of ions and water. Cells forming an epithelial layer are bound together by a tight junction that forms a barrier to ion flux. Ions and water are transported via specialized molecules. The presence of a defect in a single ion channel molecule leads to cystic fibrosis - the most common, fatal, human genetic disease. The paper describes ion transport data obtained by means of different experimental techniques...
March 22, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28342731/preferred-management-of-primary-deep-arm-vein-thrombosis
#14
REVIEW
F J Vazquez, P Paulin, D Poodts, E Gándara
OBJECTIVE: Given its rarity, the management of primary upper extremity deep vein thrombosis is controversial. Although anticoagulation alone is commonly advocated for its treatment, it is unclear if this will reduce the risk of developing post-thrombotic syndrome (PTS). The aim of this "Evidence Driven" Clinical Scenario is to evaluate whether more aggressive treatments (including catheter directed thrombolysis or surgery) might help reduce the risk of PTS or recurrent venous thromboembolism in patients with primary upper extremity deep vein thrombosis (DVT)...
March 22, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28342717/slow-chromatin-dynamics-allow-polycomb-target-genes-to-filter-fluctuations-in-transcription-factor-activity
#15
Scott Berry, Caroline Dean, Martin Howard
Genes targeted by Polycomb repressive complex 2 (PRC2) are regulated in cis by chromatin modifications and also in trans by diffusible regulators such as transcription factors. Here, we introduce a mathematical model in which transcription directly antagonizes Polycomb silencing, thereby linking these cis- and trans-regulatory inputs to gene expression. The model is parameterized by recent experimental data showing that PRC2-mediated repressive chromatin modifications accumulate extremely slowly. The model generates self-perpetuating, bistable active and repressed chromatin states that persist through DNA replication, thereby ensuring high-fidelity transmission of the current chromatin state...
March 21, 2017: Cell Systems
https://www.readbyqxmd.com/read/28342687/analysis-of-the-best-available-techniques-for-wastewaters-from-a-denim-manufacturing-textile-mill
#16
H Yukseler, N Uzal, E Sahinkaya, M Kitis, F B Dilek, U Yetis
The present study was undertaken as the first plant scale application and evaluation of Best Available Techniques (BAT) within the context of the Integrated Pollution Prevention and Control/Industrial Emissions Directive to a textile mill in Turkey. A "best practice example" was developed for the textile sector; and within this context, BAT requirements for one of the World's leading denim manufacturing textile mills were determined. In order to achieve a sustainable wastewater management; firstly, a detailed wastewater characterization study was conducted and the possible candidate wastewaters to be reused within the mill were identified...
March 22, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28342652/effective-hospital-wide-education-in-hemorrhage-control
#17
James R Hegvik, Sarah K Spilman, Sherry D Olson, Carrie A Gilchrist, Richard A Sidwell
BACKGROUND: Uncontrolled hemorrhage is the leading cause of potentially preventable traumatic death. Bleeding victims must receive immediate medical attention to save lives, and the first opportunity to control bleeding after trauma often comes from bystanders. Educating the general public is important for improving outcomes for hemorrhaging victims, and it is imperative for all people, including those with no clinical training, to have the knowledge to respond until trained medical specialists arrive...
March 4, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28340466/a-flexible-and-disposable-battery-powered-by-bacteria-using-eyeliner-coated-paper-electrodes
#18
Ramya Veerubhotla, Debabrata Das, Debabrata Pradhan
Herein, an environment friendly paper-based biobattery is demonstrated that yields a power of 12.5W/m(3). Whatman filter papers were used not only as support for electrode fabrication but also as separator of the biobattery. To provide electrical conductivity to the paper-based cathode and anode, commercially available eyeliner containing carbon nanoparticles and Fe3O4 was directly employed as conductive ink without any binder. With an instant start-up, the as-fabricated biocompatible electrodes could hold bacteria in an active form at the anode allowing chemical oxidation of organic fuel producing current...
March 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28340416/nonradical-oxidation-from-electrochemical-activation-of-peroxydisulfate-at-ti-pt-anode-efficiency-mechanism-and-influencing-factors
#19
Haoran Song, Linxia Yan, Jun Ma, Jin Jiang, Guangqiang Cai, Wenjuan Zhang, Zhongxiang Zhang, Jiaming Zhang, Tao Yang
Electrochemical activation of peroxydisulfate (PDS) at Ti/Pt anode was systematically investigated for the first time in this work. The synergistic effect produced from the combination of electrolysis and the addition of PDS demonstrates that PDS can be activated at Ti/Pt anode. The selective oxidation towards carbamazepine (CBZ), sulfamethoxazole (SMX), propranolol (PPL), benzoic acid (BA) rather than atrazine (ATZ) and nitrobenzene (NB) was observed in electrochemical activation of PDS process. Moreover, addition of excess methanol or tert-butanol had negligible impact on CBZ (model compound) degradation, demonstrating that neither sulfate radical (SO4(-)) nor hydroxyl radical (HO) was produced in electrochemical activation of PDS process...
March 21, 2017: Water Research
https://www.readbyqxmd.com/read/28340069/the-association-of-post-traumatic-and-postmigration-stress-with-pain-and-other-somatic-symptoms-an-explorative-analysis-in-traumatized-refugees-and-asylum-seekers
#20
Naser Morina, Alexa Kuenburg, Ulrich Schnyder, Richard A Bryant, Angela Nickerson, Matthis Schick
Objective.:  Post-traumatic stress disorder (PTSD) and somatic symptoms, such as pain, are frequently seen in refugees. Their relationship is poorly understood, and the treatment of these comorbid conditions can be very challenging. The current cross-sectional study examined pain and other somatic symptoms and their relationship with trauma history, PTSD symptom clusters, and current living difficulties among treatment-seeking refugees. Methods.:  One hundred thirty-four treatment-seeking traumatized refugees (78% male, mean age = 42 years) were assessed regarding lifetime traumatic experiences, symptoms of post-traumatic stress, overall pain and somatic symptoms, and postmigration living difficulties...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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