keyword
MENU ▼
Read by QxMD icon Read
search

Direct current

keyword
https://www.readbyqxmd.com/read/29228372/a-novel-tomographic-imaging-probe-for-rapid-diagnosis-of-fungal-keratitis
#1
Min Hee Lee, Gregory Wiedman, Steven Park, Arkady Mustaev, Yanan Zhao, David S Perlin
Fungal keratitis is a leading cause of ocular morbidity and blindness in developing countries. Diagnosing fungal keratitis currently relies on a comparative evaluation of corneal biopsy or scraping using a direct microscopy and culture results. These methods not only carry the risk of developing complications due to the invasive tissue sampling but also are largely limited by diagnostic speed and accuracy, making it difficult to initiate timely appropriate antifungal therapy. Therefore, rapid and noninvasive diagnostic tools are a pressing need for improved outcomes for fungal keratitis...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228358/theta-resting-eeg-in-tpj-psts-is-associated-with-individual-differences-in-the-feeling-of-being-looked-at
#2
Lorena R R Gianotti, Janek S Lobmaier, Cinzia Calluso, Franziska M Dahinden, Daria Knoch
Direct eye gaze is a powerful stimulus in social interactions, yet people vary considerably in the range of gaze lines that they accept as being direct (cone of direct gaze, CoDG). Here, we searched for a possible neural trait marker of these individual differences. We measured the width of the CoDG in 137 healthy participants and related their individual CoDG to their neural baseline activation as measured with resting electroencephalogram (EEG). Using a source-localization technique, we found that resting theta current density in the left temporo-parietal junction (TPJ) and adjacent posterior superior temporal sulcus (pSTS) was associated with the width of CoDG...
December 7, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29228279/in-vitro-model-of-fully-differentiated-human-nasal-epithelial-cells-infected-with-rhinovirus-reveals-epithelium-initiated-immune-responses
#3
Kai Sen Tan, Hsiao Hui Ong, Yan Yan, Jing Liu, Chunwei Li, Yew Kwang Ong, Kim Thye Thong, Hyung Won Choi, De-Yun Wang, Vincent T Chow
Human rhinoviruses (HRVs) are the commonest cause of the common cold. While less pathogenic compared to other respiratory viruses, it is frequently associated with exacerbation of chronic respiratory diseases such as rhinosinusitis and asthma exacerbation. Currently, there are limited studies on HRV infection of nasal epithelial cells despite being the first site of viral contact, immune initiation, and airway inter-connectivity. Hence, we established a model of HRV infection of in vitro differentiated human nasal epithelial cells (hNECs) derived from multiple individuals...
December 8, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29228172/spring-a-kinetic-interface-for-visualizing-high-dimensional-single-cell-expression-data
#4
Caleb Weinreb, Samuel Wolock, Allon Klein
Motivation: Single-cell gene expression profiling technologies can map the cell states in a tissue or organism. As these technologies become more common, there is a need for computational tools to explore the data they produce. In particular, visualizing continuous gene expression topologies can be improved, since current tools tend to fragment gene expression continua or capture only limited features of complex population topologies. Results: Force-directed layouts of k-nearest-neighbor graphs can visualize continuous gene expression topologies in a manner that preserves high-dimensional relationships and captures complex population topologies...
December 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29228074/a-review-of-the-current-therapies-challenges-and-future-directions-of-transcranial-focused-ultrasound-technology-advances-in-diagnosis-and-treatment
#5
Vibhor Krishna, Francesco Sammartino, Ali Rezai
Importance: Magnetic resonance imaging-guided focused ultrasound ablation has been approved for the treatment of refractory essential tremor and is being studied for other neurological indications, including dyskinesias and tremor in Parkinson disease, dystonia, neuropathic pain, obsessive-compulsive disorder, epilepsy, and brain tumors. Objective: To review the scientific foundations of FUS technology, existing neurological applications, and future advances. Evidence Review: PubMed was searched for the past 10 years using the terms "transcranial ultrasound," "focused ultrasound," and "neurological applications...
December 11, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29228053/traditional-scientific-data-vs-uncoordinated-citizen-science-effort-a-review-of-the-current-status-and-comparison-of-data-on-avifauna-in-southern-brazil
#6
Louri Klemann-Junior, Marcelo Alejandro Villegas Vallejos, Pedro Scherer-Neto, Jean Ricardo Simões Vitule
Data generated by citizen science is particularly valuable in ecological research. If used discerningly with data from traditional scientific references, citizen science can directly contribute to biogeography knowledge and conservation policies by increasing the number of species records in large geographic areas. Considering the current level of knowledge on south Brazilian avifauna, the large volume of data produced by uncoordinated citizen science effort (CS), and the growing need for information on changes in abundance and species composition, we have compiled an updated, general list of bird species occurrence within the state of Paraná...
2017: PloS One
https://www.readbyqxmd.com/read/29228004/longitudinal-assessment-of-anti-pgl-i-serology-in-contacts-of-leprosy-patients-in-bangladesh
#7
Renate A Richardus, Konrad van der Zwet, Anouk van Hooij, Louis Wilson, Linda Oskam, Roel Faber, Susan J F van den Eeden, David Pahan, Khorshed Alam, Jan Hendrik Richardus, Annemieke Geluk
BACKGROUND: Despite elimination efforts, the number of Mycobacterium leprae (M. leprae) infected individuals who develop leprosy, is still substantial. Solid evidence exists that individuals living in close proximity to patients are at increased risk to develop leprosy. Early diagnosis of leprosy in endemic areas requires field-friendly tests that identify individuals at risk of developing the disease before clinical manifestation. Such assays will simultaneously contribute to reduction of current diagnostic delay as well as transmission...
December 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29227897/sleep-difficulties-in-college-students-the-role-of-stress-affect-and-cognitive-processes
#8
Ana Paula Amaral, Maria João Soares, Ana Margarida Pinto, Ana Telma Pereira, Nuno Madeira, Sandra Carvalho Bos, Mariana Marques, Carolina Roque, António Macedo
Previous research indicates that sleep difficulties and stress are prevalent in college students. The main aim of the current study was to investigate the role of repetitive negative thinking (RNT), cognitive emotion regulation, and negative affect as mediators of the relationship between stress and sleep difficulties. We also intended to analyse the associations between all these variables and the gender differences. A sample of 549 college students completed self-report measures assessing the mentioned variables...
December 2, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29227838/financial-strain-indirectly-influences-smoking-cessation-through-withdrawal-symptom-severity
#9
Darla E Kendzor, Michael S Businelle, Aaron F Waters, Summer G Frank, Emily T Hébert
BACKGROUND: Financial strain has an adverse impact on smoking cessation. However, the mechanisms through which financial strain influences cessation remain unclear. The purpose of the current study was to determine whether financial strain indirectly influenced smoking cessation through withdrawal symptom severity. METHODS: Participants (N=139) were primarily Black (63.3%) and female (57.6%) adults enrolled in a smoking cessation program at a safety-net hospital...
December 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29227715/human-papillomavirus-genome-integration-and-head-and-neck-cancer
#10
L M Pinatti, H M Walline, T E Carey
We conducted a critical review of human papillomavirus (HPV) integration into the host genome in oral/oropharyngeal cancer, reviewed the literature for HPV-induced cancers, and obtained current data for HPV-related oral and oropharyngeal cancers. In addition, we performed studies to identify HPV integration sites and the relationship of integration to viral-host fusion transcripts and whether integration is required for HPV-associated oncogenesis. Viral integration of HPV into the host genome is not required for the viral life cycle and might not be necessary for cellular transformation, yet HPV integration is frequently reported in cervical and head and neck cancer specimens...
December 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29227557/building-organic-inorganic-hybrid-interphases-for-fast-interfacial-transport-in-rechargeable-metal-batteries
#11
Qing Zhao, Zhengyuan Tu, Shuya Wei, Kaihang Zhang, Snehashis Choudhury, Xiaotun Liu, Lynden Archer
We report a facile, in-situ synthesis to create durable, hybrid Solid-electrolyte interphases (SEI) on metal anodes. Composed of Si-interlinked molecules that host LiCl salt, the hybrid SEI exhibit fast charge-transfer kinetics and high exchange current densities. By means of electrochemical analysis and direct optical visualization of Li and Na deposition in symmetric Li/Li and Na/Na cells, it is further shown that the hybrid SEI enables excellent morphological control at relatively high current densities (3-5 mA/cm2) and even for notoriously unstable Na metal anodes...
December 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29227525/functional-electrical-stimulation-and-ankle-foot-orthoses-provide-equivalent-therapeutic-effects-on-foot-drop-a-meta-analysis-providing-direction-for-future-research
#12
Sarah Prenton, Kristen L Hollands, Laurence P J Kenney, Pornsuree Onmanee
OBJECTIVE: To compare the randomized controlled trial evidence for therapeutic effects on walking of functional electrical stimulation and ankle foot orthoses for foot drop caused by central nervous system conditions. DATA SOURCES: MEDLINE, CINAHL, Cochrane Central Register of Controlled Trials, REHABDATA, PEDro, NIHR Centre for Reviews and Dissemination, Scopus and clinicaltrials.gov. STUDY SELECTION: One reviewer screened titles/abstracts...
November 17, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29227456/photopolymerized-microfeatures-guide-adult-spiral-ganglion-and-dorsal-root-ganglion-neurite-growth
#13
Linjing Xu, Alison E Seline, Braden Leigh, Mark Ramirez, C Allan Guymon, Marlan R Hansen
HYPOTHESIS: Microtopographical patterns generated by photopolymerization of methacrylate polymer systems will direct growth of neurites from adult neurons, including spiral ganglion neurons (SGNs). BACKGROUND: Cochlear implants (CIs) provide hearing perception to patients with severe to profound hearing loss. However, their ability to encode complex auditory stimuli is limited due, in part, to poor spatial resolution caused by spread of the electrical currents in the inner ear...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29227432/cpd-and-kt-models-used-and-opportunities-for-synergy
#14
Joan Sargeant, Francine Borduas, Anne Sales, Doug Klein, Brenna Lynn, Heather Stenerson
The two fields of continuing professional development (CPD) and knowledge translation (KT) within the health care sector, and their related research have developed as somewhat parallel paths with limited points of overlap or intersection. This is slowly beginning to change. The purpose of this paper is to describe and compare the dominant conceptual models informing each field with the view of increasing understanding and appreciation of the two fields, how they are similar and where they differ, and the current and potential points of intersection...
October 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29227091/a-vuv-excited-and-ch2cl2-h2o-amplified-ionization-coupled-mass-spectrometry-for-oxygenated-organics-analysis
#15
Bo Yang, Haixu Zhang, Jinian Shu, Pengkun Ma, Peng Zhang, Jingyun Huang, Zhen Li, Ce Xu
The mass spectrometry analysis of oxygenated volatile organic compounds (OVOCs) remains challenging due to their limited ionization efficiencies. In this study, we surprisingly found that, under VUV excitation, a gaseous mixture of CH2Cl2/H2O/analyte (OVOCs) in N2 buffer generated large amounts of H3O+ and protonated analyte even when the photon energy was lower than the ionization energy of the neutral species involved. In contrast to those obtained with VUV photoionization alone, the signal intensities of oxygenated organics can be amplified by more than three orders of magnitude...
December 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29226959/larvivorous-fish-for-preventing-malaria-transmission
#16
REVIEW
Deirdre P Walshe, Paul Garner, Ahmed A Adeel, Graham H Pyke, Thomas R Burkot
BACKGROUND: Adult female Anopheles mosquitoes can transmit Plasmodium parasites that cause malaria. Some fish species eat mosquito larvae and pupae. In disease control policy documents, the World Health Organization (WHO) includes biological control of malaria vectors by stocking ponds, rivers, and water collections near where people live with larvivorous fish to reduce Plasmodium parasite transmission. In the past, the Global Fund has financed larvivorous fish programmes in some countries, and, with increasing efforts in eradication of malaria, policymakers may return to this option...
December 11, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29226950/syndecans-in-chronic-inflammatory-and-autoimmune-diseases-pathological-insights-and-therapeutic-opportunities
#17
REVIEW
Solomon A Agere, Eugene Y Kim, Nahid Akhtar, Salahuddin Ahmed
Syndecans (SDCs) are a family of heparan sulfate proteoglycans (HSPGs) glycoproteins ubiquitously expressed on the cell surfaces and extracellular matrix of all mammalian tissues. There are four mammalian syndecans, SDC-1 thorough 4, which play a critical role in cell adhesion, migration, proliferation, differentiation, and angiogenesis through independent and growth factor mediated signaling. An altered expression of SDCs is often observed in autoimmune disorders, cancer, HIV infection, and many other pathological conditions...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29226617/activation-of-glucagon-like-peptide-1-receptors-in-the-nucleus-accumbens-attenuates-cocaine-seeking-in-rats
#18
Nicole S Hernandez, Bernadette O'Donovan, Pavel I Ortinski, Heath D Schmidt
Recent evidence indicates that activation of glucagon-like peptide-1 (GLP-1) receptors reduces cocaine-mediated behaviors and cocaine-evoked dopamine release in the nucleus accumbens (NAc). However, no studies have examined the role of NAc GLP-1 receptors in the reinstatement of cocaine-seeking behavior, an animal model of relapse. Here, we show that systemic infusion of a behaviorally relevant dose of the GLP-1 receptor agonist exendin-4 penetrated the brain and localized with neurons and astrocytes in the NAc...
December 11, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29226492/molecular-mechanisms-underlying-monosynaptic-sensory-motor-circuit-development-in-the-spinal-cord
#19
REVIEW
Fumiyasu Imai, Yutaka Yoshida
Motor behaviors are precisely controlled by the integration of sensory and motor systems in the central nervous system (CNS). Proprioceptive sensory neurons, key components of the sensory system, are located in the dorsal root ganglia and project axons both centrally to the spinal cord and peripherally to muscles and tendons, communicating peripheral information about the body to the CNS. Changes in muscle length detected by muscle spindles, and tension variations in tendons conveyed by golgi tendon organs, are communicated to the CNS through group Ia/II, and Ib proprioceptive sensory afferents, respectively...
December 11, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/29226323/cops5-and-lasp1-synergistically-interact-to-down-regulate-14-3-3%C3%AF-expression-and-promote-colorectal-cancer-progression-via-activating-pi3k-akt-pathway
#20
Rui Zhou, Ziyun Shao, Jian Liu, Wanqi Zhan, Qingzu Gao, Zhihua Pan, Ling Wu, Lijun Xu, Yanqing Ding, Liang Zhao
Overexpression of LIM and SH3 protein 1 (LASP1) is required for colorectal cancer (CRC) development and progression. Here, C-Jun activation domain-binding protein-1 (Jab1), also known as COPS5, was verified as a new LASP1-interacting protein through yeast two-hybrid assay. The role of COPS5 in LASP1-mediated CRC progression remains unknown. GST pull-down assay indicated that the SH3 domain of LASP1 could directly bind to MPN domain of COPS5. In vitro gain- and loss-of-function analyses revealed the stimulatory role of COPS5 on CRC cell proliferation, migration and invasion...
December 11, 2017: International Journal of Cancer. Journal International du Cancer
keyword
keyword
110421
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"