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https://www.readbyqxmd.com/read/28102980/microbiology-devices-reclassification-of-influenza-virus-antigen-detection-test-systems-intended-for-use-directly-with-clinical-specimens-final-order
#1
(no author information available yet)
The Food and Drug Administration (FDA) is reclassifying antigen based rapid influenza virus antigen detection test systems intended to detect influenza virus directly from clinical specimens that are currently regulated as influenza virus serological reagents from class I into class II with special controls and into a new device classification regulation.
12, 2017: Federal Register
https://www.readbyqxmd.com/read/28102827/a-low-cost-scalable-current-sensing-digital-headstage-for-high-channel-count-%C3%A2%C2%B5ecog
#2
Michael Trumpis, Michele Insanally, Jialin Zou, Ashraf ElSharif, Ali Ghomashchi, N Sertac Artan, Robert Froemke, Jonathan Viventi
OBJECTIVE: High channel count electrode arrays allow for the monitoring of large-scale neural activity at high spatial resolution. Implantable arrays featuring many recording sites require compact, high bandwidth front-end electronics. In the present study, we investigated the use of a small, light weight, and low cost digital current-sensing integrated circuit for acquiring cortical surface signals from a 61-channel micro-electrocorticographic (��ECoG) array. APPROACH: We recorded both acute and chronic ��ECoG signal from rat auditory cortex using our novel digital current-sensing headstage...
January 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28102734/fibroblast-like-synoviocytes-dependent-effector-molecules-as-a-critical-mediator-for-rheumatoid-arthritis-current-status-and-future-directions
#3
Ramamoorthi Ganesan, Mahaboobkhan Rasool
Rheumatoid arthritis (RA) is a systemic-autoimmune-mediated disease characterized by synovial hyperplasia and progressive destruction of joint. Currently available biological agents and inhibitor therapy that specifically target tumor necrosis factor-α, interleukin 1β (IL-1β), IL-6, T cells, B cells, and subcellular molecules (p38 mitogen-activated protein kinase and janus kinase) cannot facilitate complete remission in all patients and are unable to cure the disease. Therefore, further potent therapeutic targets need to be identified for effective treatment and successful clinical outcomes in patients with RA...
January 19, 2017: International Reviews of Immunology
https://www.readbyqxmd.com/read/28102733/plk1-polo-like-kinase-1-inhibits-mtor-complex-1-and-promotes-autophagy
#4
Stefanie Ruf, Alexander Martin Heberle, Miriam Langelaar-Makkinje, Sara Gelino, Deepti Wilkinson, Carolin Gerbeth, Jennifer Jasmin Schwarz, Birgit Holzwarth, Bettina Warscheid, Chris Meisinger, Marcel A T M van Vugt, Ralf Baumeister, Malene Hansen, Kathrin Thedieck
Mechanistic target of rapamycin complex 1 (MTORC1) and PLK1 (polo like kinase 1) are major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are currently being investigated in clinical studies. To date, MTORC1's and PLK1's functions are mostly studied separately, and reports on their mutual crosstalk are scarce. Here, we identify PLK1 as a physical MTORC1 interactor in human cancer cells. PLK1 inhibition enhances MTORC1 activity under nutrient sufficiency and in starved cells, and PLK1 directly phosphorylates the MTORC1 component RPTOR/RAPTOR in vitro...
January 19, 2017: Autophagy
https://www.readbyqxmd.com/read/28102702/immunomodulating-peptides-for-food-allergy-prevention-and-treatment
#5
Daniel Lozano-Ojalvo, Rosina López-Fandiño
Among the most promising strategies currently assayed against IgE-mediated allergic diseases stands the possibility of using immunomodulating peptides to induce oral tolerance towards offending food allergens or even to prevent allergic sensitization. This review focuses on the beneficial effects of food derived immunomodulating peptides on food allergy, which can be directly exerted in the intestinal tract or once being absorbed through the intestinal epithelial barrier to interact with immune cells. Food peptides influence intestinal homeostasis by maintaining and reinforcing barrier function or affecting intestinal cell-signalling to nearby immune cells and mucus secretion...
January 19, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28102566/annual-research-review-understudied-populations-within-the-autism-spectrum-current-trends-and-future-directions-in-neuroimaging-research
#6
REVIEW
Allison Jack, Kevin A Pelphrey
BACKGROUND: Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental conditions that vary in both etiology and phenotypic expression. Expressions of ASD characterized by a more severe phenotype, including autism with intellectual disability (ASD + ID), autism with a history of developmental regression (ASD + R), and minimally verbal autism (ASD + MV) are understudied generally, and especially in the domain of neuroimaging. However, neuroimaging methods are a potentially powerful tool for understanding the etiology of these ASD subtypes...
January 19, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28102560/the-epidemiology-of-inflammatory-bowel-diseases-from-west-to-east
#7
Zsuzsanna Vegh, Zsuzsanna Kurti, Peter Lakatos
The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographic regions. The first studies on the epidemiology of IBD were available mainly from traditionally high-incidence areas, as North America and Northern and Western Europe. In the last two decades, more and more data have been reported from Eastern European and Asian counties with increasing incidence rates from some regions. According to recent studies, the high incidence and prevalence of IBD in some Western countries is plateauing and in some Eastern countries increasing incidence rates have been reported...
January 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28102378/a-high-performance-supercapacitor-electrode-based-on-tremella-like-nic2o4-nio-core-shell-hierarchical-nanostructures-on-nickel-foam
#8
Dong He, Guolong Liu, Anqi Pang, Yang Jiang, Hui Suo, Chun Zhao
Tremella-like nickel oxalate@nickel oxide (NiC2O4@NiO) core/shell hierarchical nanostructures have been successfully synthesized on nickel foam, using Ni foam as a current collector, a Ni source and a three-dimensional (3D) substrate, through a facile hydrothermal method followed by an electrochemical activation process. The prepared samples can be directly used as binder-free electrodes for supercapacitors. The tremella-like morphology, together with the NiC2O4 nanoblocks on 3D Ni foam, significantly increases the amount of active sites for redox reactions and the conductivity of the electrode material, shortens the diffusion pathway for ions, facilitates the effective penetration of the electrolyte, and lowers the intrinsic equivalent series resistance, demonstrating good potential for energy storage application...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102356/unlocking-the-potential-of-sns2-transition-metal-catalyzed-utilization-of-reversible-conversion-and-alloying-reactions
#9
Zhi Xiang Huang, Ye Wang, Bo Liu, Dezhi Kong, Jun Zhang, Tupei Chen, Hui Ying Yang
The alloying-dealloying reactions of SnS2 proceeds with the initial conversion reaction of SnS2 with lithium that produces Li2S. Unfortunately, due to the electrochemical inactivity of Li2S, the conversion reaction of SnS2 is irreversible, which significantly limit its potential applications in lithium-ion batteries. Herein, a systematic understanding of transition metal molybdenum (Mo) as a catalyst in SnS2 anode is presented. It is found that Mo catalyst is able to efficiently promote the reversible conversion of Sn to SnS2...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102239/subcycle-quantum-electrodynamics
#10
C Riek, P Sulzer, M Seeger, A S Moskalenko, G Burkard, D V Seletskiy, A Leitenstorfer
Squeezed states of electromagnetic radiation have quantum fluctuations below those of the vacuum field. They offer a unique resource for quantum information systems and precision metrology, including gravitational wave detectors, which require unprecedented sensitivity. Since the first experiments on this non-classical form of light, quantum analysis has been based on homodyning techniques and photon correlation measurements. These methods currently function in the visible to near-infrared and microwave spectral ranges...
January 18, 2017: Nature
https://www.readbyqxmd.com/read/28101842/violence-exposure-subtypes-differentially-mediate-the-relation-between-callous-unemotional-traits-and-adolescent-delinquency
#11
Carla Oberth, Yao Zheng, Robert J McMahon
Research with children and adolescents has established a link between callous-unemotional (CU) traits and delinquency, as well as a link between violence exposure (witnessing and direct victimization) and diverse negative and antisocial outcomes. Little attention has been paid to investigating the association among CU traits, violence exposure, and various forms of delinquency. Using a sample of 753 adolescents (male =58%; African American =46%), the current study aimed to elucidate the mediating role of violence exposure (measured in grades 7, 8, 10, 11) on the relationship between CU traits measured in grade 7 and later delinquency (i...
January 19, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28101828/current-trends-in-the-diagnosis-and-management-of-syndesmotic-injury
#12
REVIEW
Matthew L Vopat, Bryan G Vopat, Bart Lubberts, Christopher W DiGiovanni
Ideal management of the various presentations of syndesmotic injury remains controversial to this day. High quality evidentiary science on this topic is rare, and numerous existing studies continue to contradict one another. The primary reasons for these discrepancies are that previous studies have failed to (1) properly distinguish between isolated (non-fractured) and non-isolated injuries, (2) accurately define stable from unstable injuries, and (3) sufficiently differentiate between acute and chronic injuries...
January 18, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28101648/the-limits-of-boundaries-unpacking-localization-and-cognitive-mapping-relative-to-a-boundary
#13
Ruojing Zhou, Weimin Mou
Previous research (Zhou, Mou, Journal of Experimental Psychology: Learning, Memory and Cognition 42(8):1316-1323, 2016) showed that learning individual locations relative to a single landmark, compared to learning relative to a boundary, led to more accurate inferences of inter-object spatial relations (cognitive mapping of multiple locations). Following our past findings, the current study investigated whether the larger number of reference points provided by a homogeneous circular boundary, as well as less accessible knowledge of direct spatial relations among the multiple reference points, would lead to less effective cognitive mapping relative to the boundary...
January 19, 2017: Psychological Research
https://www.readbyqxmd.com/read/28101230/effect-of-il-17-in-the-development-of-colon-cancer-in-mice
#14
Lijuan Yang, Hao Liu, Lili Zhang, Jie Hu, Haixia Chen, Lei Wang, Xiaolin Yin, Quanhai Li, Yixin Qi
Cytokine therapy is commonly used for tumor immunotherapy. Although early studies focused directly on the tumor, current investigations are more attentive of the tumor microenvironment. Various immune cells and related cytokines in the tumor microenvironment play an important role in the occurrence and development of tumor. Interleukin (IL)-17 is the characteristic cytokine produced by Th17 cells. IL-17 has been associated with various immune responses. The results of previous studies showed that IL-17 can significantly reduce the size of transplanted tumors in tumor-bearing mice, albeit it has no effect on the survival time of mice...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100802/hydrodynamic-detection-and-localization-of-artificial-flatfish-breathing-currents-by-harbour-seals-phoca-vitulina
#15
Benedikt Niesterok, Yvonne Krüger, Sven Wieskotten, Guido Dehnhardt, Wolf Hanke
Harbour seals are known to be opportunistic feeders, whose diet consists mainly of pelagic and benthic fish, such as flatfish. As flatfish are often cryptic and do not produce noise, we hypothesized that harbour seals are able to detect and localize flatfish using their hydrodynamic sensory system (vibrissae), as fish emit water currents through their gill openings (breathing currents). To test this hypothesis, we created an experimental platform where an artificial breathing current was emitted through one of eight different openings...
January 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28100742/visual-sampling-predicts-hippocampal-activity
#16
Zhong-Xu Liu, Kelly Shen, Rosanna K Olsen, Jennifer D Ryan
: Eye movements serve to accumulate information from the visual world, contributing to the formation of coherent memory representations that support cognition and behavior. The hippocampus and the oculomotor network are well connected anatomically through an extensive set of polysynaptic pathways. However, the extent to which visual sampling behavior is related to functional responses in the hippocampus during encoding has not been studied directly in human neuroimaging. In the current study, participants engaged in a face processing task while brain responses were recorded with fMRI and eye movements were monitored simultaneously...
January 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28100719/testing-for-departure-from-uniformity-and-estimating-mean-direction-for-circular-data
#17
Graeme D Ruxton
Although circular data are common in biological studies, the analysis of such data is often more rudimentary than it need be. One of the most common hypotheses tested is whether the data suggest that samples are clustered around a certain specified direction, rather than being uniformly spread across all possible directions. Here, I use data from a recent publication on the compass directions of epiphytes and mistletoes on tree trunks. This is used to demonstrate how with relatively little extra work researchers can improve the rigour of testing such hypotheses, and this improved rigour can lead to biological insights missed by simpler analyses...
January 2017: Biology Letters
https://www.readbyqxmd.com/read/28100588/involvement-of-conserved-amino-acids-in-the-c-terminal-region-of-line-1-orf2p-in-retrotransposition
#18
Claiborne M Christian, Mark Sokolowski, Dawn deHaro, Kristine J Kines, Victoria P Belancio
Long Interspersed Element 1 (LINE-1 or L1) is the only currently active autonomous retroelement in the human genome. Along with the parasitic SVA and SINE Alu, L1 is the source of DNA damage induced by retrotransposition, a copy-and-paste process that has the potential to disrupt gene function and cause human disease. The retrotransposition process is dependent upon the ORF2 protein (ORF2p). However, it is unknown whether most of the protein is important for retrotransposition. In particular, other than the Cys motif, the C-terminus of the protein has not been intensely examined in the context of retrotransposition...
January 18, 2017: Genetics
https://www.readbyqxmd.com/read/28100546/accuracy-of-line-probe-assays-for-the-diagnosis-of-pulmonary-and-multidrug-resistant-tuberculosis-a-systematic-review-and-meta-analysis
#19
Ruvandhi R Nathavitharana, Patrick G T Cudahy, Samuel G Schumacher, Karen R Steingart, Madhukar Pai, Claudia M Denkinger
Only 25% of multidrug-resistant tuberculosis (MDR-TB) cases are currently diagnosed. Line probe assays (LPAs) enable rapid drug-susceptibility testing for rifampicin (RIF) and isoniazid (INH) resistance and Mycobacterium tuberculosis detection. Genotype MTBDRplusV1 was WHO-endorsed in 2008 but newer LPAs have since been developed.This systematic review evaluated three LPAs: Hain Genotype MTBDRplusV1, MTBDRplusV2 and Nipro NTM+MDRTB. Study quality was assessed with QUADAS-2. Bivariate random-effects meta-analyses were performed for direct and indirect testing...
January 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28100478/adropin-acts-in-the-rat-paraventricular-nucleus-to-influence-neuronal-excitability
#20
Spencer P Loewen, Alastair V Ferguson
Adropin is a peptide hormone with cardiovascular and metabolic roles in the periphery, including effects on glucose and lipid homeostasis. Central administration of adropin has been shown to inhibit water intake in rats, however, the site at which central adropin acts has yet to be elucidated. The hypothalamic paraventricular nucleus (PVN), a critical autonomic control center, plays essential roles in the control of fluid balance, energy homeostasis and cardiovascular regulation, and is therefore a potential target for centrally acting adropin...
January 18, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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