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auditory evoked responses

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https://www.readbyqxmd.com/read/28211449/translational-use-of-event-related-potentials-to-assess-circuit-integrity-in-asd
#1
REVIEW
Meera E Modi, Mustafa Sahin
Deficits in social cognition are the defining characteristic of autism spectrum disorder (ASD). Social cognition requires the integration of several neural circuits in a time-sensitive fashion, so impairments in social interactions could arise as a result of alterations in network connectivity. Electroencephalography (EEG) has revealed abnormalities in event related potentials (ERPs) evoked by auditory and visual sensory stimuli in humans with ASD, indicating disruption of neural connectivity. Similar abnormalities in sensory-evoked ERPs have been observed in animal models of ASD, suggesting that ERPs have the potential to provide a translational biomarker of the disorder...
February 17, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28211069/mglur1-enhances-efferent-inhibition-of-inner-hair-cells-in-the-developing-rat-cochlea
#2
Zhanlei Ye, Juan D Goutman, Sonja J Pyott, Elisabeth Glowatzki
Just before the onset of hearing, the inner hair cells (IHCs) receive inhibitory efferent input from cholinergic medial olivocochlear (MOC) neurons originating in the brainstem. This input may serve a role in the maturation of the ascending (afferent) auditory system by inhibiting spontaneous activity of the IHCs. To investigate the molecular mechanisms regulating these IHC efferent synapses, we combined electrical stimulation of the efferent fibres with patch clamp recordings from the IHCs to measure efferent synaptic strength...
February 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28207576/relationship-between-peripheral-and-psychophysical-measures-of-amplitude-modulation-detection-in-cochlear-implant-users
#3
Viral D Tejani, Paul J Abbas, Carolyn J Brown
OBJECTIVE: This study investigates the relationship between electrophysiological and psychophysical measures of amplitude modulation (AM) detection. Prior studies have reported both measures of AM detection recorded separately from cochlear implant (CI) users and acutely deafened animals, but no study has made both measures in the same CI users. Animal studies suggest a progressive loss of high-frequency encoding as one ascends the auditory pathway from the auditory nerve to the cortex...
February 15, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28203210/auditory-and-visual-electrophysiology-of-deaf-children-with-cochlear-implants-implications-for-cross-modal-plasticity
#4
David P Corina, Shane Blau, Todd LaMarr, Laurel A Lawyer, Sharon Coffey-Corina
Deaf children who receive a cochlear implant early in life and engage in intensive oral/aural therapy often make great strides in spoken language acquisition. However, despite clinicians' best efforts, there is a great deal of variability in language outcomes. One concern is that cortical regions which normally support auditory processing may become reorganized for visual function, leaving fewer available resources for auditory language acquisition. The conditions under which these changes occur are not well understood, but we may begin investigating this phenomenon by looking for interactions between auditory and visual evoked cortical potentials in deaf children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28202466/time-varying-auditory-gain-control-in-response-to-double-pulse-stimuli-in-harbour-porpoises-is-not-mediated-by-a-stapedial-reflex
#5
Asger Emil Munch Schrøder, Kristian Beedholm, Peter Teglberg Madsen
Echolocating animals reduce their output level and hearing sensitivity, presumably to stabilize the perceived echo intensity during target approaches. In bats this variation in hearing sensitivity is formed by a call-induced stapedial reflex that tapers off over time after the call. Here we test the hypothesis that a similar mechanism exists in toothed whales by subjecting a trained harbour porpoise to a series of double sound pulses varying in delay and frequency, while measuring the magnitudes of the evoked ABRs...
February 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28202254/robust-interactions-between-the-effects-of-auditory-and-cutaneous-electrical-stimulations-on-cell-activities-in-the-thalamic-reticular-nucleus
#6
Akihisa Kimura
The thalamic reticular nucleus (TRN), a cluster of GABAergic cells, is thought to regulate bottom-up and top-down streams of sensory processing in the loop circuitry between the thalamus and cortex. Provided that sensory inputs of different modalities interact in the TRN, the TRN could contribute to fast and flexible cross-modal modulation of attention and perception that incessantly takes place in our every day life. Indeed, diverse subthreshold interactions of auditory and visual inputs have been revealed in TRN cells (Kimura, 2014)...
February 12, 2017: Brain Research
https://www.readbyqxmd.com/read/28192769/disorganization-at-the-stage-of-schizophrenia-clinical-outcome-clinical-biological-study
#7
A Nestsiarovich, V Obyedkov, H Kandratsenka, M Siniauskaya, I Goloenko, N Waszkiewicz
BACKGROUND: According to the multidimensional model of schizophrenia, three basic psychopathological dimensions constitute its clinical structure: positive symptoms, negative symptoms and disorganization. The latter one is the newest and the least studied. Our aim was to discriminate disorganization in schizophrenia clinical picture and to identify its distinctive biological and socio-psychological particularities and associated genetic and environmental factors. METHODS: We used SAPS/SANS psychometrical scales, scales for the assessment of patient's compliance, insight, social functioning, life quality...
December 30, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28188855/auditory-processing-assessment-suggests-that-wistar-audiogenic-rat-neural-networks-are-prone-to-entrainment
#8
Hyorrana Priscila Pereira Pinto, Vinícius Rezende Carvalho, Daniel de Castro Medeiros, Ana Flávia Santos Almeida, Eduardo Mazoni Andrade Marçal Mendes, Marcio Flávio Dutra Moraes
Epilepsy is a neurological disease related to the occurrence of pathological oscillatory activity, but the basic physiological mechanisms of seizure remain to be understood. Our working hypothesis is that specific sensory processing circuits may present abnormally enhanced predisposition for coordinated firing in the dysfunctional brain. Such facilitated entrainment could share a similar mechanistic process as those expediting the propagation of epileptiform activity throughout the brain. To test this hypothesis, we employed the Wistar audiogenic rat (WAR) reflex animal model, which is characterized by having seizures triggered reliably by sound...
February 7, 2017: Neuroscience
https://www.readbyqxmd.com/read/28188216/amygdalar-gating-of-early-sensory-processing-through-interactions-with-locus-coeruleus
#9
Cynthia D Fast, John P McGann
Fear- and stress-induced activity in the amygdala has been hypothesized to influence sensory brain regions through the amygdala's influence on neuromodulatory centers. To directly examine this relationship, we used optical imaging to observe odor-evoked activity in populations of olfactory bulb inhibitory interneurons and of synaptic terminals of olfactory sensory neurons (the olfactory system's primary sensory neurons, which provide the initial olfactory input to the brain) during pharmacological inactivation of amygdala and locus coeruleus (LC) in mice...
February 10, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28185890/-recording-the-human-brainstem-frequency-following-response-in-the-free-field
#10
Nuno Gama, Isabelle Peretz, Alexandre Lehmann
BACKGROUND: The human auditory brainstem frequency-following response (FFR) is an objective measure used to investigate the brainstem's encoding ability of sounds. Traditionally, FFRs are recorded under close-field conditions (earphones), but free-field stimulations (loudspeaker) have yet to be attempted, which would increase the applications of FFRs by making this technique accessible to those who cannot wear inserted transducers. Here we test the feasibility and reliability of measuring speech ABRs across free and close-field...
February 6, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28184188/stimulus-phase-locking-of-cortical-oscillations-for-rhythmic-tone-sequences-in-rats
#11
Takahiro Noda, Tomoki Amemiya, Tomoyo I Shiramatsu, Hirokazu Takahashi
Humans can rapidly detect regular patterns (i.e., within few cycles) without any special attention to the acoustic environment. This suggests that human sensory systems are equipped with a powerful mechanism for automatically predicting forthcoming stimuli to detect regularity. It has recently been hypothesized that the neural basis of sensory predictions exists for not only what happens (predictive coding) but also when a particular stimulus occurs (predictive timing). Here, we hypothesize that the phases of neural oscillations are critical in predictive timing, and these oscillations are modulated in a band-specific manner when acoustic patterns become predictable, i...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28183797/ca-2-binding-protein-2-inhibits-ca-2-channel-inactivation-in-mouse-inner-hair-cells
#12
Maria Magdalena Picher, Anna Gehrt, Sandra Meese, Aleksandra Ivanovic, Friederike Predoehl, SangYong Jung, Isabelle Schrauwen, Alberto Giulio Dragonetti, Roberto Colombo, Guy Van Camp, Nicola Strenzke, Tobias Moser
Ca(2+)-binding protein 2 (CaBP2) inhibits the inactivation of heterologously expressed voltage-gated Ca(2+) channels of type 1.3 (CaV1.3) and is defective in human autosomal-recessive deafness 93 (DFNB93). Here, we report a newly identified mutation in CABP2 that causes a moderate hearing impairment likely via nonsense-mediated decay of CABP2-mRNA. To study the mechanism of hearing impairment resulting from CABP2 loss of function, we disrupted Cabp2 in mice (Cabp2(LacZ/LacZ) ). CaBP2 was expressed by cochlear hair cells, preferentially in inner hair cells (IHCs), and was lacking from the postsynaptic spiral ganglion neurons (SGNs)...
February 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28183580/effect-of-total-intravenous-vs-volatile-anesthetics-on-intraoperatively-acquired-electrically-evoked-compound-action-potential-in-children-undergoing-cochlear-implant-surgery-a-randomized-prospective-study
#13
Ala A Alhowary, Khaled El-Radaideh, Anas Al-Rusan, Diab Bani Hani, Wail Khraise, Ahmad Al Omari, Firas Alzoubi
OBJECTIVE: The purpose of the present study was to compare the effects of inhalational anesthesia to those of total intravenous anesthesia on intraoperative electrically evoked compound action potential (e-ECAP) thresholds in children undergoing cochlear implantation. STUDY DESIGN: Randomized prospective study. SETTING: Tertiary referral teaching hospital. PATIENTS: Forty children aged 6 months to 17years with bilateral severe-to-profound sensorineural hearing loss and undergoing cochlear implantation were enrolled in the study...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28182973/dyslexia-risk-gene-relates-to-representation-of-sound-in-the-auditory-brainstem
#14
Nicole E Neef, Bent Müller, Johanna Liebig, Gesa Schaadt, Maren Grigutsch, Thomas C Gunter, Arndt Wilcke, Holger Kirsten, Michael A Skeide, Indra Kraft, Nina Kraus, Frank Emmrich, Jens Brauer, Johannes Boltze, Angela D Friederici
Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory brainstem remains to be investigated. Here, we quantified the response consistency of speech-evoked brainstem responses to the acoustically presented syllable [da] in 159 genotyped, literate and preliterate children...
January 17, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28180042/brainstem-auditory-evoked-potentials-diagnostic-accuracy-for-hearing-loss-systematic-review-and-meta-analysis
#15
Parthasarathy D Thirumala, Gregory Carnovale, Yoon Loke, Miguel E Habeych, Donald J Crammond, Jeffrey R Balzer, Raymond F Sekula
Background Microvascular decompression (MVD) utilizes brainstem auditory evoked potential (BAEP) intraoperative monitoring to reduce the risk of iatrogenic hearing loss. Studies report varying efficacy and hearing loss rates during MVD with intraoperative monitoring. Objectives This study aims to perform a comprehensive review and study of diagnostic accuracy of BAEPs during MVD to predict hearing loss in studies published from January 1984 to December 2013. Methods The PubMed/MEDLINE and World Science databases were searched...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28177924/adapted-wavelet-transform-improves-time-frequency-representations-a-study-of-auditory-elicited-p300-like-event-related-potentials-in-rats
#16
Nelly Richard, Bettina Laursen, Morten Grupe, Asbjørn M Drewes, Carina Graversen, Helge B D Sørensen, Jesper F Bastlund
OBJECTIVE: Active auditory oddball paradigms are simple tone discrimination tasks used to study the P300 deflection of event-related potentials (ERPs). These ERPs may be quantified by time-frequency analysis. As auditory stimuli cause early high frequency and late low frequency ERP oscillations, the continuous wavelet transform (CWT) is often chosen for decomposition due to its multi-resolution properties. However, as the conventional CWT traditionally applies only one mother wavelet to represent the entire spectrum, the time-frequency resolution is not optimal across all scales...
February 8, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28177264/gender-disparities-in-speech-evoked-auditory-brainstem-response-in-healthy-adults
#17
Bahram Jalaei, Mohd Normani Zakaria, Mohd Hafiz Afifi Mohd Azmi, Nik Adilah Nik Othman, Dinsuhaimi Sidek
OBJECTIVES: Gender disparities in speech-evoked auditory brainstem response (speech-ABR) outcomes have been reported, but the literature is limited. The present study was performed to further verify this issue and determine the influence of head size on speech-ABR results between genders. METHODS: Twenty-nine healthy Malaysian subjects (14 males and 15 females) aged 19 to 30 years participated in this study. After measuring the head circumference, speech-ABR was recorded by using synthesized syllable /da/ from the right ear of each participant...
February 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28174530/an-event-related-field-study-of-rapid-grammatical-plasticity-in-adult-second-language-learners
#18
Ainhoa Bastarrika, Douglas J Davidson
The present study used magnetoencephalography (MEG) to investigate how Spanish adult learners of Basque respond to morphosyntactic violations after a short period of training on a small fragment of Basque grammar. Participants (n = 17) were exposed to violation and control phrases in three phases (pretest, training, generalization-test). In each phase participants listened to short Basque phrases and they judged whether they were correct or incorrect. During the pre-test and generalization-test, participants did not receive any feedback...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28169838/estimation-of-minor-conductive-hearing-loss-in-humans-using-distortion-product-otoacoustic-emissions
#19
Steven C Marcrum, Peter Kummer, Thomas Steffens
OBJECTIVES: Conductive hearing loss (CHL) systematically alters distortion product otoacoustic emission (DPOAE) levels through attenuation of both the primary tones and the evoked response by the middle ear, as well as through modification of the effective L1-L2 relationship within the cochlea. It has been postulated that, if optimal primary tone level relationships for an ear without CHL are known or can be estimated accurately and a CHL can be presumed to attenuate both primary tones to a similar extent, the adjustment to L1 required to restore an optimal L1-L2 separation following CHL induction can be utilized to estimate CHL magnitude objectively...
February 6, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28167132/identification-of-induced-and-naturally-occurring-conductive-hearing-loss-in-mice-using-bone-conduction
#20
David Chhan, Melissa L McKinnon, John J Rosowski
While many mouse models of hearing loss have been described, a significant fraction of the genetic defects in these models affect both the inner ear and middle ears. A common method used to separate inner-ear (sensory-neural) from middle-ear (conductive) pathologies in the hearing clinic is the combination of air-conduction and bone-conduction audiometry. In this report, we investigate the use of air- and bone-conducted evoked auditory brainstem responses to perform a similar separation in mice. We describe a technique by which we stimulate the mouse ear both acoustically and via whole-head vibration...
February 4, 2017: Hearing Research
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