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auditory evoked responses

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https://www.readbyqxmd.com/read/28927910/hearing-outcome-following-microvascular-decompression-for-hemifacial-spasm-series-of-1434-cases
#1
Na Young Jung, Si Woo Lee, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
OBJECTIVE: Although hearing impairment after microvasuclar decompression (MVD) for hemifacial spasm (HFS) is not common, its occurrence could detrimentally affect the patient`s surgical outcome. The object of this study is to address the optimal approaches for reducing postoperative hearing problems after MVD for HFS. METHODS: We retrospectively analyzed the medical records of patients with HFS who underwent MVD with the same surgeon at our institute from March 2003 to October 2016, and reviewed the pertinent literature...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28925523/bdnf-haplo-insufficiency-impairs-high-frequency-cortical-oscillations-in-mice
#2
Nigel C Jones, Matthew Hudson, Joshua Foreman, Gil Rind, Rachel Hill, Elizabeth E Manning, Maarten van den Buuse
Schizophrenia is a complex psychiatric disorder with a heterogeneous aetiology involving genetic and environmental factors. Deficiencies in both brain-derived neurotrophic factor (BDNF) and NMDA receptor function have been implicated in the disorder, and may play causal and synergistic roles. Perturbations in the regulation of electrophysiological signals, including high-frequency (gamma: 30-80 Hz and beta: 20-30 Hz) neuronal oscillations, are also associated with the disorder. This study investigated the influence of BDNF deficiency and NMDA receptor hypofunction on electrophysiological responses to brief acoustic stimuli...
September 19, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28925372/an-automatic-algorithm-for-blink-artifact-suppression-based-on-iterative-template-matching-application-to-single-channel-recording-of-cortical-auditory-evoked-potentials
#3
Joaquin T Valderrama, Angel de la Torre, Bram Van Dun
Artifact reduction in electroencephalogram (EEG) signals is usually necessary to carry out data analysis appropriately. Despite the large amount of denoising techniques available with a multichannel setup, there is a lack of efficient algorithms that remove (not only detect) blink-artifacts from a single channel EEG, which is of interest in many clinical and research applications. This paper describes and evaluates the Iterative Template Matching and Suppression (ITMS), a new method proposed for detecting and suppressing the artifact associated with the blink activity from a single channel EEG...
September 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28924582/data-on-the-effect-of-conductive-hearing-loss-on-auditory-and-visual-cortex-activity-revealed-by-intrinsic-signal-imaging
#4
Manuel Teichert, Jürgen Bolz
This data article provides additional data related to the research article entitled "Simultaneous intrinsic signal imaging of auditory and visual cortex reveals profound effects of acute hearing loss on visual processing" (Teichert and Bolz, 2017) [1]. The primary auditory and visual cortex (A1 and V1) of adult male C57BL/6J mice (P120-P240) were mapped simultaneously using intrinsic signal imaging (Kalatsky and Stryker, 2003) [2]. A1 and V1 activity evoked by combined auditory and visual stimulation were measured before and after conductive hearing loss (CHL) induced by bilateral malleus removal...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28924008/primary-generators-of-visually-evoked-field-potentials-recorded-in-the-macaque-auditory-cortex
#5
Yoshinao Kajikawa, John F Smiley, Charles E Schroeder
Prior studies have reported "local" field potential (LFP) responses to faces in the macaque auditory cortex and have suggested that such face-LFPs may be substrates of audiovisual integration. However, while field potentials (FPs) may reflect the synaptic currents of neurons near the recording electrode, due to the use of a distant reference electrode, they often reflect those of synaptic activity occurring in distant sites as well. Thus, FP recordings within a given brain region (e.g., auditory cortex) may be "contaminated" by activity generated elsewhere in the brain...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28923485/functional-data-analysis-of-single-trial-auditory-evoked-potentials-recorded-in-the-awake-rat
#6
Ondrej Pokora, Jan Kolaicek, Tzai-Wen Chiu, Wei Qiu
Evoked potentials (EPs) reflect neural processing and are widely used to study sensory perception. However, methods of analyzing EP have been limited mostly to the conventional ensemble averaging of EP response trials to a repeated stimulus, and less so to single-trials analysis. Here we applied a new approach - functional data analysis (FDA) - to study auditory EP in the rat model of tinnitus, in which overdoses of salicylate (SS) are known to alter sound perception characteristically, as the same way as in humans...
September 15, 2017: Bio Systems
https://www.readbyqxmd.com/read/28922984/cortical-auditory-evoked-potential-caep-and-behavioural-measures-of-auditory-function-in-a-child-with-a-single-sided-deafness
#7
Oscar M Cañete, Suzanne C Purdy, Michel Neeff, Colin R S Brown, Peter R Thorne
OBJECTIVES: To study the changes in behavioural and cortical responses over time in a child with single-sided deafness fitted with a cochlear implant (CI). METHODS: Cortical auditory evoked potentials (CAEPs) in noise (+5 dB signal-to-noise ratio) were recorded and auditory skills were assessed using tests of sound localization, spatial speech perception in noise, and self-ratings of auditory abilities (Listening inventory for education, LIFE and Speech, spatial and qualities of hearing questionnaire, SSQ parental version)...
September 19, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28922980/a-genome-wide-association-study-of-early-gamma-band-response-in-a-schizophrenia-case-control-sample
#8
Bettina Konte, Gregor Leicht, Ina Giegling, Oliver Pogarell, Susanne Karch, Annette M Hartmann, Marion Friedl, Ulrich Hegerl, Dan Rujescu, Christoph Mulert
OBJECTIVES: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity. METHODS: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315). RESULTS: No marker surpassed the threshold for genome-wide significant association...
September 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28919848/hidden-hearing-loss-no-effect-of-common-recreational-noise-exposure-on-cochlear-nerve-response-amplitude-in-humans
#9
Sarah K Grinn, Kathryn B Wiseman, Jason A Baker, Colleen G Le Prell
This study tested hypothesized relationships between noise exposure and auditory deficits. Both retrospective assessment of potential associations between noise exposure history and performance on an audiologic test battery and prospective assessment of potential changes in performance after new recreational noise exposure were completed. Methods: 32 participants (13M, 19F) with normal hearing (25-dB HL or better, 0.25-8 kHz) were asked to participate in 3 pre- and post-exposure sessions including: otoscopy, tympanometry, distortion product otoacoustic emissions (DPOAEs) (f2 frequencies 1-8 kHz), pure-tone audiometry (0...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28918681/neonate-auditory-brainstem-response-repeatability-with-controlled-force-gauge-bone-conducted-stimulus-delivery
#10
Andrew Stuart, Hannah M Dorothy
OBJECTIVE: The feasibility and repeatability of neonate auditory brainstem responses (ABRs) with a controlled hand-held applied force gauge for bone-conducted stimulus delivery was examined. DESIGN: A repeated measures test-retest design was employed. STUDY SAMPLE: Participants were 27 healthy neonates. A 4000 Hz bone-conducted CE-Chirp octave band stimulus evoked the ABRs. Intra- and intertester conditions were employed with a prototype hand-held applied force gauge (Etymōtic Research) attached to the superior aspect of the bone vibrator...
September 18, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28917659/sonification-of-scalp-recorded-frequency-following-responses-ffrs-offers-improved-response-detection-over-conventional-statistical-metrics
#11
Gavin M Bidelman
BACKGROUND: The human frequency-following response (FFR) is a neurophonic potential used to examine the brain's encoding of complex sounds (e.g., speech) and monitor neuroplastic changes in auditory processing. Given the FFR's low amplitude (order of nanovolts), current conventions in literature recommend collecting several thousand trials to obtain a robust evoked response with adequate signal-to-noise ratio. NEW METHOD: By exploiting the spectrotemporal fidelity of the response, we examined whether auditory playbacks (i...
September 13, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28917446/amplitude-modulation-rate-dependent-topographic-organization-of-the-auditory-steady-state-response-in-human-auditory-cortex
#12
Nathan Weisz, Chrysoula Lithari
Periodic modulations of an acoustic feature, such as amplitude over a certain frequency range, leads to phase locking of neural responses to the envelope of the modulation. Using electrophysiological methods this neural activity pattern, also called the auditory steady-state response (aSSR), is visible following frequency transformation of the evoked response as a clear spectral peak at the modulation frequency. Despite several studies employing the aSSR that show, for example, strongest responses for ∼40 Hz and an overall right-hemispheric dominance, it has not been investigated so far to what extent within auditory cortex different modulation frequencies elicit aSSRs at a homogenous source or whether the localization of the aSSR is topographically organized in a systematic manner...
September 11, 2017: Hearing Research
https://www.readbyqxmd.com/read/28906245/potential-audiological-and-mri-markers-of-tinnitus
#13
Kamakshi V Gopal, Binu P Thomas, Rajesh Nandy, Deng Mao, Hanzhang Lu
BACKGROUND: Subjective tinnitus, or ringing sensation in the ear, is a common disorder with no accepted objective diagnostic markers. PURPOSE: The purpose of this study was to identify possible objective markers of tinnitus by combining audiological and imaging-based techniques. RESEARCH DESIGN: Case-control studies. STUDY SAMPLE: Twenty adults drawn from our audiology clinic served as participants. The tinnitus group consisted of ten participants with chronic bilateral constant tinnitus, and the control group consisted of ten participants with no history of tinnitus...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28894145/characterization-of-volume-based-changes-in-cortical-auditory-evoked-potentials-and-prepulse-inhibition
#14
Thomas Potter, Sheng Li, Thinh Nguyen, Trac Nguyen, Nuri Ince, Yingchun Zhang
The auditory evoked startle reflex is a conserved response resulting in neurological and motor activity. The presence of a mild prepulse immediately before the main pulse inhibits startle responses, though the mechanism for this remains unknown. In this study, the electroencephalography (EEG) data recorded from 15 subjects was analyzed to study the N1 and P2 components of cortical auditory evoked potentials (CAEPs) evoked by 70, 80, 90, 100, and 110 dB stimuli both in the presence and absence of 70 dB prepulses...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891823/longitudinal-changes-in-electrically-evoked-auditory-event-related-potentials-in-children-with-auditory-brainstem-implants-preliminary-results-recorded-over-3-years
#15
Shuman He, Holly F B Teagle, Tyler C McFayden, Matthew Ewend, Lillian Henderson, Nancy He, Craig A Buchman
OBJECTIVES: This preliminary study aimed (1) to assess longitudinal changes in electrically evoked auditory event-related potentials (eERPs) in children with auditory brainstem implants (ABIs) and (2) to explore whether these changes could be accounted for by maturation in the central auditory system of these patients. DESIGN: Study participants included 5 children (S1 to S5) with an ABI in the affected ear. The stimulus was a train of electrical pulses delivered to individual ABI electrodes via a research interface...
September 7, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28887876/cell-specific-gain-modulation-by-synaptically-released-zinc-in-cortical-circuits-of-audition
#16
Charles T Anderson, Manoj Kumar, Shanshan Xiong, Thanos Tzounopoulos
In many excitatory synapses, mobile zinc is found within glutamatergic vesicles and is coreleased with glutamate. Ex vivo studies established that synaptically released (synaptic) zinc inhibits excitatory neurotransmission at lower frequencies of synaptic activity but enhances steady state synaptic responses during higher frequencies of activity. However, it remains unknown how synaptic zinc affects neuronal processing in vivo. Here, we imaged the sound-evoked neuronal activity of the primary auditory cortex in awake mice...
September 9, 2017: ELife
https://www.readbyqxmd.com/read/28885234/assessing-the-relationship-between-the-electrically-evoked-compound-action-potential-and-speech-recognition-abilities-in-bilateral-cochlear-implant-recipients
#17
Kara C Schvartz-Leyzac, Bryan E Pfingst
OBJECTIVES: The primary objective of the present study was to examine the relationship between suprathreshold electrically evoked compound action potential (ECAP) measures and speech recognition abilities in bilateral cochlear implant listeners. We tested the hypothesis that the magnitude of ear differences in ECAP measures within a subject (right-left) could predict the difference in speech recognition performance abilities between that subject's ears (right-left). DESIGN: To better control for across-subject variables that contribute to speech understanding, the present study used a within-subject design...
September 6, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28879632/real-time-clustered-multiple-signal-classification-rtc-music
#18
Christoph Dinh, Lorenz Esch, Johannes Rühle, Steffen Bollmann, Daniel Güllmar, Daniel Baumgarten, Matti S Hämäläinen, Jens Haueisen
Magnetoencephalography (MEG) and electroencephalography provide a high temporal resolution, which allows estimation of the detailed time courses of neuronal activity. However, in real-time analysis of these data two major challenges must be handled: the low signal-to-noise ratio (SNR) and the limited time available for computations. In this work, we present real-time clustered multiple signal classification (RTC-MUSIC) a real-time source localization algorithm, which can handle low SNRs and can reduce the computational effort...
September 6, 2017: Brain Topography
https://www.readbyqxmd.com/read/28874607/no-sensitive-guanylate-cyclase-isoforms-no-gc1-and-no-gc2-contribute-to-noise-induced-inner-hair-cell-synaptopathy
#19
Dorit Möhrle, Katrin Reimann, Steffen Wolter, Markus Wolters, Ksenya Varakina, Evanthia Mergia, Nicole Eichert, Hyun-Soon Geisler, Peter Sandner, Peter Ruth, Andreas Friebe, Robert Feil, Ulrike Zimmermann, Doris Koesling, Marlies Knipper, Lukas Rüttiger
Nitric oxide (NO) activates the NO-sensitive soluble guanylate cyclase (NO-GC, sGC) and triggers intracellular signaling pathways involving cGMP. For survival of cochlear hair cells and preservation of hearing, NO-mediated cascades have both protective and detrimental potential. Here we examine the cochlear function of mice lacking one of the two NO-sensitive guanylate cyclase isoforms [NO-GC1 knockout (KO) or NO-GC2 KO]. The deletion of NO-GC1 or NO-GC2 did not influence electromechanical outer hair cell (OHC) properties, as measured by distortion product otoacoustic emissions, neither before nor after noise exposure, nor were click- or noise-burst-evoked auditory brainstem response thresholds different from controls...
October 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28869786/population-pharmacokinetic-pharmacodynamic-modelling-of-auditory-evoked-event-related-potentials-with-lorazepam
#20
Aurélie Lombard, Claire Brittain, Graham Wishart, Stephen Lowe, Andrew McCarthy, William Landschulz, Georg Dorffner, Peter Anderer, Eunice Yuen
Event-Related Potentials (ERPs) are commonly used in Neuroscience research, particularly the P3 waveform because it is associated with cognitive brain functions and is easily elicited by auditory or sensory inputs. ERPs are affected by drugs such as lorazepam, which increase the latency and decrease the amplitude of the P3 wave. In this study, auditory-evoked ERPs were generated in 13 older healthy volunteers using an oddball tone paradigm, after administration of single 0.5 and 2mg doses of lorazepam. Population pharmacokinetics (PK)/ pharmacodynamics (PD) models were developed using non-linear mixed effects methods in order to assess the effect of lorazepam on the latency and amplitude of the P3 waveforms...
September 4, 2017: Basic & Clinical Pharmacology & Toxicology
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